博士（理学）, 京都大学

Biophysics

Cell biology

Biophysics, chemical physics and soft matter physics

2024 - Present
Shinshu University, Graduate School of Medicine, Science and Technology, Specially Appointed Professor

2023 - Present
RIKEN, Center for Biosystems Dynamics Research, Team Leader

2022 - 2023
Kyoto University, Graduate School of Science, 特定准教授

2020 - 2024
JST PRESTO, PRESTO Reseacher

2018 - 2020
Institut Curie, Invited Researcher

2017 - 2022
Kyoto University, Graduate School of Science, 連携准教授

2017 - 2022
Kyoto University, The Hakubi Center for Advanced Research, 特定准教授

2017 - 2018
Waseda University, 先進理工学部物理学科, 非常勤講師

2016 - 2017
WABIOS (Waseda Bioscience Research Institute in Singapore), 研究所員

2015 - 2017
Waseda University, Department of Physics, 助教

2011 - 2015
Waseda University, Faculty of Science and Engineering, 次席研究員

2008 - 2011
Japan Society for the Promotion of Science, 特別研究員（DC1）

2008 - 2011, Kyoto University, Graduate School of Science, Division of Physics and Astronomy

2006 - 2008, Waseda University, Graduate School of Science and Engineering, 物理学及応用物理学専攻

2002 - 2006, Waseda University, School of Science and Engineering, Department of Physics

2025 - Present
分野別専門委員（分野：非平衡・自己組織化）, 日本生物物理学会

2024 - Present
代議員, 日本細胞生物学会

2023 - 2023
日本生物物理学会 分野別専門委員（分野：非平衡・自己組織化）

2022 - 2022
日本生物物理学会 分野別専門委員（分野：生命現象の基本原理）

2021 - 2022
日本生物物理学会 邦文誌「生物物理」編集委員

2022
The Young Scientists’ Award (MEXT)

Optogenetic actin network assembly on lipid bilayer uncovers the network density-dependent functions of actin-binding proteins
Kei Yamamoto; Makito Miyazaki
bioRxiv, Dec. 2024
Last, Corresponding

Chimeras of Kinesin-6 and Kinesin-14 reveal head-neck-tail domain functions and dysfunctions that lead to aneuploidy in fission yeast
Priyanka Sasmal; Makito Miyazaki; Frédérique Carlier-Grynkorn; Phong T. Tran
bioRxiv, Aug. 2024, Not invited

Protein design of two-component tubular assemblies like cytoskeletons
Masahiro Noji; Yukihiko Sugita; Yosuke Yamazaki; Makito Miyazaki; Yuta Suzuki
bioRxiv, Apr. 2024

Controlling physical and biochemical parameters of actin nucleation using a patterned model lipid membrane
Yosuke Yamazaki; Yuuri Miyata; Kenichi Morigaki; Makito Miyazaki
Nano Letters, 24(6), 1825-1834, Jan. 2024, Refereed
Last, Corresponding

State transitions of a confined actomyosin system controlled through contractility and polymerization rate
Ryota Sakamoto; Makito Miyazaki; Yusuke T. Maeda
Physical Review Research, 5, 013208, Mar. 2023, Refereed, Not invited

Uncovering the design principles of supramolecular assemblies through manipulation of the structures, dynamics, and functions
Makito Miyazaki; Takahiro Kosugi
Biophysics and Physicobiology, 19, n/a-n/a, Aug. 2022, Refereed, Not invited
Lead, Corresponding

Geometric trade-off between contractile force and viscous drag determines the actomyosin-based motility of a cell-sized droplet
Ryota Sakamoto; Ziane Izri; Yuta Shimamoto; Makito Miyazaki; Yusuke T. Maeda
PNAS, 119(30), Jul. 2022, Refereed

Microscopic temperature control reveals cooperative regulation of actin–myosin interaction by drebrin E
Hiroaki Kubota; Hiroyuki Ogawa; Makito Miyazaki; Shuya Ishii; Kotaro Oyama; Yuki Kawamura; Shin’ichi Ishiwata; Madoka Suzuki
Nano Letters, Nov. 2021, Refereed
Lead

Tug-of-war between actomyosin-driven antagonistic forces determines the positioning symmetry in cell-sized confinement
Ryota Sakamoto; Masatoshi Tanabe; Tetsuya Hiraiwa; Kazuya Suzuki; Shin’ichi Ishiwata; Yusuke T. Maeda; Makito Miyazaki
Nature Communications, 11(1), 3063, Dec. 2020, Refereed, Not invited
Last, Corresponding

Processive nanostepping of formin mDia1 loosely coupled with actin polymerization
Kubota H; Miyazaki M; Ogawa T; Shimozawa T; Kinosita K Jr; Ishiwata S
Nano Letters, 18(10), 6617-6624, Oct. 2018, Refereed, Not invited
Corresponding

Biphasic effect of profilin impacts the formin mDia1 force-sensing mechanism in actin polymerization
Hiroaki Kubota; Makito Miyazaki; Taisaku Ogawa; Togo Shimozawa; Kazuhiko Kinosita; Shin'ichi Ishiwata
Biophysical Journal, 113(2), 461-471, Jul. 2017, Refereed, Not invited
Corresponding

Spatial confinement of active microtubule networks induces large-scale rotational cytoplasmic flow
Kazuya Suzuki; Makito Miyazaki; Jun Takagi; Takeshi Itabashi; Shin'ichi Ishiwata
PNAS, 114(11), 2922-2927, Mar. 2017, Refereed, Not invited
Corresponding

Dynamic properties of bio-motile systems with a liquid-crystalline structure
Shin'ichi Ishiwata; Makito Miyazaki; Katsuhiko Sato; Koutaro Nakagome; Seine A. Shintani; Fuyu Kobirumaki-Shimozawa; Norio Fukuda; Kazuya Suzuki; Jun Takagi; Yuta Shimamoto; Takeshi Itabashi
Molecular Crystals and Liquid Crystals, 647(1), 127-150, 2017, Refereed, Invited

In vitro再構成による収縮環の形成機構の解明
宮﨑 牧人; 石渡 信一
生物物理, 56(3), 174-176, 2016, Refereed, Not invited

Directional bleb formation in spherical cells under temperature gradient
Kotaro Oyama; Tomomi Arai; Akira Isaka; Taku Sekiguchi; Hideki Itoh; Yusuke Seto; Makito Miyazaki; Takeshi Itabashi; Takashi Ohki; Madoka Suzuki; Shin'ichi Ishiwata
Biophysical Journal, 109(2), 355-364, Jul. 2015, Refereed, Not invited

Cell-sized spherical confinement induces the spontaneous formation of contractile actomyosin rings in vitro
Makito Miyazaki; Masataka Chiba; Hiroki Eguchi; Takashi Ohki; Shin'ichi Ishiwata
Nature Cell Biology, 17(4), 480-+, Apr. 2015, Refereed, Not invited
Lead

Preparation of cell-sized water-in-oil droplets for in vitro reconstitution of biological processes in cellular compartments
Miyazaki M; Chiba M; Ishiwata S
Protocol Exchange, Mar. 2015, Not invited
Lead, Corresponding

Quantitative analysis of the lamellarity of giant liposomes prepared by the inverted emulsion method
Masataka Chiba; Makito Miyazaki; Shin'ichi Ishiwata
Biophysical Journal, 107(2), 346-354, Jul. 2014, Refereed, Not invited
Lead

Accurate polarity control and parallel alignment of actin filaments for myosin-powered transport systems
Makito Miyazaki; Kazuhiko Kinosita; Katsuyuki Shiroguchi
RSC Advances, 3(23), 8728-8733, 2013, Refereed, Not invited
Lead

ランジュバン系に対するベイズ推定：１分子時系列からタンパク質の粗視化モデルを構築する
宮﨑 牧人
日本数理生物学会ニュースレター, (64(別冊)), May 2011, Not invited

Go-and-Back method: Effective estimation of the hidden motion of proteins from single-molecule time series
Makito Miyazaki; Takahiro Harada
Journal of Chemical Physics, 134(13), 135104, Apr. 2011, Refereed, Not invited
Lead, Corresponding

Bayesian estimation of the internal structure of proteins from single-molecule measurements
Makito Miyazaki; Takahiro Harada
Journal of Chemical Physics, 134(8), 085108, Feb. 2011, Refereed, Not invited
Lead, Corresponding

月刊科学雑誌『Newton』別冊「人体ではたらく細胞のすべて」
馬渕一誠; 石渡信一; 宮﨑牧人; 村田隆; 篠原彰; 五島剛太; 北島智也; 胡桃坂仁志, Contributor, 4. 超精密！細胞分裂のメカニズム
ニュートンプレス, Oct. 2024
ISBN:9784315528589

実験医学 2024年6月号
宮﨑牧人, Contributor, News & Hot Paper Digest「再構成で捉えたアクチン骨格分解の分子機序」
羊土社, Jun. 2024

実験医学 2023年8月号
宮﨑牧人, Contributor, News & Hot Paper Digest「微小管の新しい修復メカニズム」
羊土社, Aug. 2023

生体の科学 Vol.73 No.4 特集 形態形成の統合的理解
宮﨑牧人, Contributor, アクチン細胞骨格構造と機能の再構成
医学書院, Aug. 2022

月刊科学雑誌『Newton』別冊「ゼロからわかる細胞と人体」
馬渕一誠; 石渡信一; 宮﨑牧人; 村田隆, Joint work, 2. 分身を作る「細胞分裂」 PART1.細胞分裂
ニュートンプレス, Mar. 2022
ISBN:9784315525304

月刊科学雑誌『Newton』別冊「ゼロからわかる細胞と人体」
馬渕一誠; 石渡信一; 宮﨑牧人; 村田隆, Joint work, 2. 分身を作る「細胞分裂」 PART1.細胞分裂
ニュートンプレス, Jun. 2020
ISBN:9784315522419

実験医学 2018年8月号 「サイズ生物学」 "生命"が固有のサイズをもつ意味とそれを決定する仕組み
山本一男; 原裕貴; 立川正志; 宮﨑牧人; 加藤節; 平島剛志; 梅園良彦; 八木光晴, Contributor, サイズ依存性から見えてきた細胞骨格の自己組織化原理
羊土社, 2186-2192 Aug. 2018
ISBN:9784758125109

月刊科学雑誌『Newton』別冊「細胞と生命」
協力; 馬渕 一誠; 石渡 信一; 宮﨑 牧人; 村田 隆; 執筆; 松田 壮一郎, Contributor, 2. 分身をつくる細胞分裂, Part1 細胞分裂
ニュートンプレス, Oct. 2017
ISBN:9784315520767

月刊科学雑誌『Newton』2017年1月号
協力; 馬渕 一誠; 石渡 信一; 宮﨑 牧人; 村田 隆; 執筆; 松田 壮一郎, Contributor, シリーズ 細胞分裂のふしぎ 第１回「細胞はいかにして二つに分裂するのか」
ニュートンプレス, pp. 82-95 Nov. 2016

新鐘 第82号
宮﨑 牧人, Contributor, 「人工細胞の可能性」
早稲田大学学生部, pp. 38-39 Apr. 2016

物理科学月刊誌『パリティ』2016年02月号
アレキサンダー・ダン; アンドリュー・プライス著; 宮﨑 牧人; 石渡 信一, Contributor, 「細胞に働く力とエネルギー論」
丸善出版, pp. 32-40 Feb. 2016

Reconstitution of active actin cortex
Makito Miyazaki
APS March Meeting 2025, Mar. 2025, Invited

Spatiotemporal control of actin network assembly on lipid membrane in a reconstituted system
Makito Miyazaki
M2T2 Meeting 2025, Feb. 2025, Invited

再構成で紐解く細胞骨格機能の自己組織化メカニズム
宮﨑 牧人
東京大学生物科学セミナー, Nov. 2024, Invited

Reconstitution of active actin cortex
Makito Miyazaki
Next-Gen Cytoskeleton Research Seminar, Nov. 2024, Invited

再構成で紐解く細胞骨格機能の自己組織化メカニズム
宮﨑牧人
金沢大学ナノ精密医学・理工学卓越大学院プログラム Student-Selected Seminar, Nov. 2024, Invited

アクトミオシンが駆動する細胞運動の再構成
宮﨑牧人
CBI学会, Oct. 2024, Invited

カエル卵抽出液で紐解くアクチン骨格機能の自己組織化メカニズム
宮﨑牧人
日本動物学会 第95回長崎大会 2024, Sep. 2024, Invited

Reconstitution of actin cytoskeletal dynamics and functions
Makito Miyazaki
NCBS-RIKEN BDR Joint Meeting, Jul. 2024, Invited

Reconstitution of actin cytoskeletal dynamics and functions
Makito Miyazaki
IUPAB 2024, Jun. 2024, Invited

Morphological transition and blebbing of cell-sized liposomes driven by the contraction of cortical actomyosin networks
Makito Miyazaki
International Symposium on mechanical control of biological self-organization, Jun. 2024, Invited

Reconstitution of actin cytoskeletal dynamics in cell-sized confinement
Makito Miyazaki
MELIS-UPF & RIKEN BDR Symposium, Apr. 2024, Invited

Building the cell from molecules: Reconstitution of actin cytoskeletal dynamics and functions
Makito Miyazaki
The 9th RIKEN Life Science Retreat, Jan. 2024, Invited

Building the cell from molecules: Reconstitution of actin cytoskeletal dynamics and functions
Makito Miyazaki
OIST-JST Joint Symposium, Jan. 2024, Invited

Self-assembly of actin cytoskeletal dynamics in artificial cells
Makito Miyazaki
25th iCeMS International Symposium "Self-Assembly Science for Unlocking Life's Secrets", Jan. 2024, Invited

人工細胞で切り拓く生命科学研究の現状と将来展望
宮﨑牧人
第1回 千里LF産学学術交流会, Dec. 2023, Invited

Reconstitution of the membrane blebbing process driven by the contraction of cortical actomyosin networks
Makito Miyazaki
The 46th Annual Meeting of the Molecular Biology Society of Japan, Dec. 2023, Invited

Morphological transitions of lipid vesicles driven by the contraction of cortical actomyosin networks
Makito Miyazaki
The 61st Annual Meeting of the Biophysical Society of Japan, Nov. 2023, Invited

構成的細胞生物学：つくることで紐解く生命現象の自己組織化メカニズム
宮﨑牧人
第63回 生物物理若手の会 夏の学校, Sep. 2023, Invited

Morphological transitions of lipid vesicles driven by the contraction of cortical actomyosin networks
Makito Miyazaki
STATPHYS28 Satellite Meeting: Statistical Physics and Information-Processing in Living Systems, Aug. 2023, Invited

アクチン細胞骨格動態の再構成
宮﨑牧人
理研シンポジウム：Synthetic Biology – 生物学の新たな潮流 –, Aug. 2023, Invited

Reconstitution of cytoskeletal structures and cell functions
Makito Miyazaki
IPR x RIKEN (BDR) Symposium 2023: Dive into Data of Life, Feb. 2023, Invited

再構成から見えてきた細胞骨格の自己組織化メカニズム
宮﨑牧人
細胞分裂研究会, Jul. 2022

人工細胞のサイズ依存性から紐解く細胞内対称性の制御メカニズム
宮﨑牧人
分子生物学会 ワークショップ「細胞スケールでの空間サイズの制御とその意味の理解」, Dec. 2021, Invited

人工細胞から探る細胞極性の自己組織化原理
宮﨑牧人
発生生物学会ワークショップ「細胞極性研究の新展開」, Apr. 2021, Invited

構成論的アプローチで探る細胞骨格機能の自己組織化原理
宮﨑牧人
基生研セミナー, Mar. 2021, Invited

最小構成分子システムによる細胞運動・分裂機能の再構成
宮﨑牧人
日本化学会第101春季大会, Mar. 2021, Invited

In vitro reconstitution of cytoskeletal dynamics
Makito Miyazaki
3rd ExCELLS Retreat for Young Scientists, Feb. 2021, Invited

アクチン細胞骨格による細胞内対称性の制御メカニズム
宮﨑牧人
第１０回分子モーター討論会, Nov. 2020, Invited

Tug-of-war between actomyosin-driven antagonistic forces determines the positioning symmetry in cell-sized confinement
Makito Miyazaki
The 72nd Annual Meeting of the Japan Society for Cell Biology, Jun. 2020, Invited

最小構成分子システムによる細胞運動・分裂機能の再構成
宮﨑牧人
日本化学会第100春季年会, 中長期テーマシンポジウム「次世代分子システムが拓く未来の化学」, Mar. 2020, Invited

The actin cytoskeleton dynamics in a cell-sized confined space
Makito Miyazaki
The 7th International Life-Science Symposium, Nov. 2019, Invited

アクトミオシンの収縮力によって動く液滴：細胞運動の構成的理解を目指して
宮﨑 牧人
第41回日本分子生物学会年会, Nov. 2018, Invited

アクチン系細胞骨格のin vitro再構成：細胞運動と細胞分裂の仕組みの包括的理解を目指して
宮﨑 牧人
第91回日本生化学会大会, Sep. 2018, Invited

タンパク質から観た細胞の世界〜タンパク質分子は如何にして”巨大”な細胞を制御しているのか？〜
宮﨑 牧人
第56回日本生物物理学会年会, 第5回会員総会シンポジウム 生物物理学の根本問題＃１：生物の物理的境界, Sep. 2018, Invited

In vitro reconstitution of actin cytoskeleton: Toward a unified understanding of the mechanics of cell motility and division
Makito Miyazaki
The 56th Annual Meeting of the Biophysical Society of Japan, Sep. 2018, Invited

細胞骨格のin vitro再構成：システムサイズ依存性から見えてきた自己組織化機構
宮﨑 牧人
2017年度生命科学系学会合同年次大会 (ConBio2017), Dec. 2017, Invited

Toward a physical understanding of the cell division machinery from the combination of single-molecule and in vitro reconstitution experiments
Miyazaki M
The 3rd Africa International Biotechnology and Biomedical Conference (AIBBC2017), Sep. 2017, Invited

構成的アプローチによる細胞骨格の自己組織化メカニズムの解明
宮﨑 牧人
2017年 日本液晶学会討論会・液晶交流会, Sep. 2017, Invited

In vitro reconstitution of contractile actomyosin rings
Miyazaki M; Ishiwata S
The 69th Annual Meeting of the Japan Society for Cell Biology, Jun. 2017, Invited

細胞分裂装置のin vitro再構成
宮﨑 牧人
アクティブマター研究会2017, Jan. 2017, Invited

細胞サイズ閉鎖空間でのアクチン細胞骨格のin vitro再構成
宮﨑 牧人
定量生物学の会 第８回年会, Jan. 2017, Invited

In vitro reconstitution of contractile actomyosin cytoskeleton
Miyazaki M; Ishiwata S
The 54th Annual Meeting of the Biophysical Society of Japan, Nov. 2016, Invited

細胞骨格のin vitro再構成：細胞骨格が司る細胞機能発現機構の解明を目指して
宮﨑 牧人
『細胞を創る』研究会9.0, Nov. 2016, Invited

細胞骨格構造のin vitro再構成
宮﨑 牧人
第６回 ソフトマター研究会, Oct. 2016, Invited

Dynamic properties of bio-motile systems as a liquid-crystalline structure
Ishiwata S; Miyazaki M; Sato K; Nakagome K; Suzuki K; Takagi J; Shimamoto Y; Itabashi T
26th International Liquid Crystal Conference (ILCC 2016), Aug. 2016, Invited

Self-organization of active cytoskeletal networks in a cell-sized confined space
Ishiwata S; Miyazaki M; Chiba M; Suzuki K
Biophysical Society 2016 Thematic Meetings “Engineering Approaches to Biomolecular Motors: From in vitro to in vivo”, Jun. 2016, Not invited

In vitro reconstitution of active cytoskeletal networks in cell-sized droplets
Miyazaki M; Suzuki K; Ishiwata S
EMN (Energy Materials Nanotechnology) Meeting on Droplets 2016, May 2016, Invited

Self-organization of contractile actomyosin rings inside a cell-sized confined space in vitro
Miyazaki M; Ishiwata S
The 93rd Annual Meeting of the Physiological Society of Japan, Mar. 2016, Invited

Reconstitution of actin cytoskeleton in a cell-sized confined space
Miyazaki M; Chiba M; Eguchi H; Ohki T; Ishiwata S
The 53rd Annual Meeting of the Biophysical Society of Japan, Sep. 2015, Invited

Cell-sized spherical confinement induces the spontaneous formation of contractile actomyosin rings in vitro
Miyazaki M
The 53rd Annual Meeting of the Biophysical Society of Japan, Sep. 2015, Invited

Cell-sized spherical confinement induces the spontaneous formation of contractile actomyosin rings in vitro
Miyazaki M
Gordon Research Conference "Motile & Contractile Systems", Jul. 2015, Not invited

細胞サイズ閉鎖空間内でのアクトミオシンリングの自発形成と収縮
宮﨑 牧人
第５回 分子モーター討論会, Jun. 2015, Invited

構成論的アプローチによるアクチン細胞骨格の形成機構の解明
宮﨑 牧人
理研セミナー, Mar. 2015, Invited

Self-organized pattern formation by actomyosin mixtures in a cell-size confined space
Miyazaki M; Chiba M; Eguchi H; Ishiwata S
The 51st Annual Meeting of the Biophysical Society of Japan, Oct. 2013, Invited

理論生物学と学習・統計との新たな接点〜1分子計測データに対するパラメータ推定
宮﨑 牧人
第13回 情報論的学習理論ワークショップ（IBIS2010）, Nov. 2010, Invited

Japanese Society for Quantitative Biology

Japan Society for Cell Biology

The Physical Society of Japan

The Biophysical Society of Japan

Development of force-measuring system for biological tissues
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Transformative Research Areas (A)
Kyoto University
2022 - 2026

アクチン細胞骨格を直接操作できるオプトジェネティクスツールの開発
科学研究費助成事業, 日本学術振興会, 挑戦的研究(萌芽)
京都大学
Jul. 2021 - Mar. 2023

分子モーターの収縮力が細胞の並進運動に変換される仕組みの構成的理解
科学研究費助成事業, 日本学術振興会, 新学術領域研究(研究領域提案型)
京都大学
Apr. 2021 - Mar. 2023

Geometric universality of ordered vortices and turbulent states in chiral active matter
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
Kyushu University
Apr. 2020 - Mar. 2023

１分子・超分子集合体・生細胞の３階層を貫くモデル実験系を用いた細胞分裂機構の解明
科学研究費助成事業, 日本学術振興会, 国際共同研究加速基金(国際共同研究強化(A))
京都大学
Nov. 2019 - Mar. 2025

生体発動分子を利用した自己駆動型人工細胞の開発と理論解析による機能の最適化
科学研究費助成事業, 日本学術振興会, 新学術領域研究(研究領域提案型)
京都大学
Apr. 2019 - Mar. 2021

Hierarchical understanding of the cell divison machinery using an in vitro reconstitution approarch
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
Jul. 2016 - Mar. 2020

Mechanics of actomyosin networks beneath the cell membrane
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (A)
Apr. 2016 - Mar. 2019

In vitro reconstitution of the spontaneous establishment of the polarity of motile cells
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research
Waseda University
Apr. 2015 - Mar. 2017

構成論的アプローチによる収縮環の収縮機構の解明
科学研究費助成事業, 日本学術振興会, 新学術領域研究(研究領域提案型)
早稲田大学
Apr. 2014 - Mar. 2016

Studies on the regulatory mechanism of actin cytoskeleton: bistabilities of the ordered structures of actomyosin mixture
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B)
Waseda University
Apr. 2012 - Mar. 2015

Regulatory Basis of Biomotility: Chemo-mechanical Feedback Loop
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (S)
Waseda University
01 Apr. 2010 - 31 Mar. 2016

化学力学変換をする酵素のエネルギー変換機構
科学研究費助成事業, 日本学術振興会, 特別研究員奨励費
京都大学
2008 - 2010