DAI Jian

Aging biology

Interdisciplinary Cluster for Cutting Edge Research Institute for Biomedical Sciences 

Assistant Professor 

Researcher Information


  • Ph. D. (Medicine), shinshu Unibversity

Research Keyword

    amyloidosis, Molecular biology

Field Of Study

  • Molecular biology, amyloidosis, porphyria

Mail Address


Educational Background

  • 2015 - 2019, Shinshu University, 医学系研究科, aging biology
  • 2005 - 2008, 華北理工大学(中国), 医学部基礎系研究科, 病理と病理生理学
Research activity information


  • Polygenic control of the wavy coat of the NCT mouse: involvement of an intracisternal A particle insertional mutation of the protease, serine 53 (Prss53) gene, and a modifier gene.
    Mori M, Liu C, Takahiro Y, Miyahara H, Dai J, Igarashi Y, Cui X, Li Y, Kang X, Higuchi K
  • Exercise suppresses mouse systemic AApoAII amyloidosis through enhancement of the p38 MAPK signaling pathway.
    Cui Xiaoran, Sawashita Jinko, Dai Jian, Liu Chang, Igarashi Yuichi, Mori Masayuki, Miyahara Hiroki, and Higuchi Keiichi
    Disease Models & Mechanisms, Jan. 2022
  • Involvement of increased endoplasmic reticulum stress in the development of cataracts in BALB.NCT-Cpoxnct mice.
    Liu C., Miyahara H., Dai J., Cui X., Li Y., Kang X., Higuchi K., Mori M.
    Exp. Eye Res., Dec. 2021電子ジャーナル
  • Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARa signaling pathway.
    Dai J, Li Y, Kametani F, Cui X, Igarashi Y, Huo J, Miyahara H, Mori M, Higuchi K
    Elife, 26 Jan. 2021, Refereed
  • Glavonoid-rich oil supplementation reduces stearoyl-coenzyme A desaturase 1 expression and improves systemic metabolism in diabetic, obese KK-Ay mice.
    Igarashi Y, Iida S, Dai J, Huo J, Cui,X, Sawashita J, Mori M, Miyahara H, Higuchi K
    Biomed Pharmacother, 2021電子ジャーナル
  • Suppression of Mouse AApoAII Amyloidosis Progression by Daily Supplementation with Oxidative Stress Inhibitors
    Dai J, Ding X, Miyahara H, Xu Z, Cui X, Igarashi Y, Sawashita J, Mori M, Higuchi K.
    Oxid Med Cell Longev., 2019, 1263274, 2019
  • Apolipoprotein A-II induces acute-phase response associated AA amyloidosis in mice through conformational changes of plasma lipoprotein structure.
    Yang M, Liu Y, Dai J, Li L, Ding X, Xu Z, Mori M, Miyahara H, Sawashita J, Higuchi K
    Sci Rep, 2018電子ジャーナル
  • Amyloidosis-inducing activity of blood cells in mouse AApoAII amyloidosis.
    Ding X, Liu Y, Yang M, Li L, Miyahara H, Dai J, Xu Z, Matsumoto K, Mori M, Higuchi K, Sawashita J
    Exp Ani, 2018電子ジャーナル
  • Coenzyme Q10 prevents senescence and dysfunction caused by oxidative stress in vascular endothelial cells.
    Huo J, Xu Z, Hosoe K, Kubo H, Miyahara H, Dai J, Mori M, Sawashita J, Higuchi K
    Oxid Med Cell Longev, 2018電子ジャーナル
  • Coenzyme Q10 improves lipid metabolism and ameliorates obesity by regulating CaMKII mediated PDE4 inhibition
    Xu Z, Huo J, Ding X, Yang M, Li L, Dai J, Hosoe K, Kubo H, Mori M, Higuchi K
    Sci Rep, 2017電子ジャーナル

Research Themes

  • the pathogenic mechanism of amyloidosis, Pathophysiology of porphyria