Academic Assembly School of Medicine and Health Sciences Institute of Medicine

School of Medicine Department of Medicine 


Researcher Information


  • Doctor of Medicine, 信州大学

Field Of Study

  • Neurology, Neurology

Educational Background

  • 1998, Shinshu University, Graduate School, Division of Medicine
  • 1991, Shinshu University, Faculty of Medicine
Research activity information


  • Therapeutic Outcome of Lenalidomide-dexamethasone in Patients with Relapsed or Refractory Systemic Immunoglobulin Light Chain (AL) Amyloidosis : A Single-center Analysis and Review of the Literature
    Ueno Akihiro, Katoh Nagaaki, Ezawa Naoki, Yoshinaga Tsuneaki, Yazaki Masahide, Sekijima Yoshiki
    The Shinshu Medical Journal, 70(1), 29-38, Feb. 2022リポジトリ電子ジャーナル
  • Searching for the Frequency of Cardiac Transthyretin Amyloidosis among Elderly Heart Failure Patients Noninvasively Using 99mTc-labeled Pyrophosphate Scintigraphy
    Miura Takashi, Okina Yoshiteru, Mochidome Tomoaki, Kobayashi Takahiro, Kasai Toshio, Ikeda Uichi, Ezawa Naoki, Sekijima Yoshiki, Kuwahara Koichiro
    The Shinshu Medical Journal, 69(1), 37-44, 10 Feb. 2021リポジトリ電子ジャーナル
  • Dialysis-related amyloidosis associated with a novel β2-microglobulin variant
    Mizuno H, Hoshino J, So M, Kogure Y, Fujii T, Ubara Y, Takaichi K, Nakaniwa T, Tanaka H, Kurisu G, Kametani F, Nakagawa M, Yoshinaga T, Sekijima Y, Higuchi K, Goto Y, Yazaki M
    Amyloid, 28(1), 42-49, 2021, Refereed電子ジャーナル
  • Development of diagnostic antibodies against immunoglobulin heavy chain variable region for heavy chain amyloidosis (AH amyloidosis)
    Nakagawa M, Yazaki M, Kametani F, Katoh N, Yoshinaga T, Higuchi K, Sekijima Y
    Pathol Int, 71(4), 245-254, 2021, Refereed電子ジャーナル
  • Giant hepatomegaly with spleno-testicular enlargement in a patient with apolipoprotein A-I amyloidosis: an uncommon type of amyloidosis in Japan.
    Yoshinaga T, Katoh N, Yazaki M, Sato M, Kametani F, Yasuda H, Watanabe K, Kawata K, Nakagawa M, Sekijima Y
    Intern Med, 60(4), 575-581, 2021, Refereed電子ジャーナル
  • Spread of vimentin-immunoreactive cells within the plaque-like lesion in the spinal anterior horn of a patient with post-poliomyelitis syndrome
    Hineno A, Oyanagi K, Yoshida T, Sakai Y, Kanno H, Sekijima Y
    Neuropathology, 41(5), 406-411, 2021, Refereed電子ジャーナル
  • Quantitative Analysis of Endocardial and Epicardial Left Ventricular Myocardial Deformation in Patients with Cardiac Amyloidosis
    Kozuka, Ayako; Koyama, Jun; Sekijima, Yoshiki; Ikeda, Uichi
    信州医学雑誌, 67(1), 49-62, 10 Feb. 2019リポジトリ
  • Pathological, biochemical, and biophysical characteristics of the transthyretin variant Y114H (p.Y134H) explain its very mild clinical phenotype
    Sekijima Y, Campos RI, Hammarström P, Nilsson KP, Yoshinaga T, Nagamatsu K, Yazaki M, Kametani F, Ikeda S
    J Peripher Nerv Syst, 20, 372-379, 2015, Refereed
  • Safety and efficacy of long-term diflunisal administration in hereditary transthyretin (ATTR) amyloidosis
    Sekijima Y, Tojo K, Morita H, Koyama J, Ikeda S
    Amyloid, 22, 79-83, 2015, Refereed
  • Transthyretin-type cerebral amyloid angiopathy: a serious complication in post-transplant patients with familial amyloid polyneuropathy
    Sekijima Y
    J Neurol Neurosurg Psychiatry, 86, 124, 2015, Refereed
  • Taransthyretin( ATTR)amyloidosis:clinical spectrum, molecular pathogenesis and disease-modifying treatments
    Sekijima Y
    J Neurol Neurosurg Psychiatry, 86, 1036-1043, 2015, Refereed
  • p.E66Q mutation in the GLA gene is associated with a high risk of cerebral small-vessel occlusion in elderly Japanese males
    Nakamura, K; Sekijima, Y; Nakamura, K; Hattori, K; Nagamatsu, K; Shimizu, Y; Yazaki, M; Sakurai, A; Endo, F; Fukushima, Y; Ikeda, SI
    EUROPEAN JOURNAL OF NEUROLOGY, 21(1), 49-56, 2014, RefereedWebofScienceリポジトリ電子ジャーナル
  • Clinical and serial MRI findings of a sialidosis type I patient with a novel missense mutation in the NEU1 gene
    Sekijima, Y; Nakamura, K; Kishida, D; Narita, A; Adachi, K; Ohno, K; Nanba, E; Ikeda, S
    INTERNAL MEDICINE, 52(1), 119-124, 2013, RefereedWebofScienceリポジトリ電子ジャーナル
  • Follow-up nationwide survey on predictive genetic testing for late-onset hereditary neurological diseases in Japan
    Tanaka, K; Sekijima, Y; Yoshida, K; Tamai, M; Kosho, T; Sakurai, A; Wakui, K; Ikeda, S; Fukushima, Y
    JOURNAL OF HUMAN GENETICS, 58(8), 560-563, 2013, RefereedWebofScienceリポジトリ電子ジャーナル
  • A novel nonsense mutation in the TITF-1 gene in a Japanese family with benign hereditary chorea
    Nakamura K, Sekijima Y, Nagamatsu K, Yoshida K, Ikeda SI
    J Neurol Sci, 313(1-2), 189-192, 2012, RefereedWebofScienceリポジトリ電子ジャーナル
  • Marked intrafamilial phenotypic variation in a family with SOD1 C111Y mutation
    Nakamura A, Hineno A, Yoshikda K, Sekijima Y, Hanaoka-Tachibana N, Takei Y, Ohara S, Ikeda SI
    Amyotroph Lateral Scler, 13, 479-486, 2012, RefereedWebofScienceリポジトリ電子ジャーナル
  • High prevalence of wild-type transthyretin deposition in patients with idiopathic carpal tunnel syndrome: a common cause of carpal tunnel syndrome in the elderly
    Sekijima Y, Uchiyama S, Tojo K, Sano K, Shimizu Y, Imaeda T, Hoshii Y, Kato H, Ikeda SI
    Hum Pathol, 42(11), 1785-1795, 2011, RefereedWebofScienceリポジトリ電子ジャーナル
  • Upper limb neuropathy such as carpal tunnel syndrome as an initial manifestation of ATTR Val30Met familial amyloid polyneuropathy
    Tojo, Kana; Tsuchiya-Suzuki, Ayako; Sekijima, Yoshiki; Morita, Hiroshi; Sumita, Naoko; Ikeda, Shu-Ichi
    AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 17(1), 32-35, May 2010, RefereedWebofScienceリポジトリ電子ジャーナル
  • Cerebral hemorrhage in Fabry's disease
    Nakamura, Katsuya; Sekijima, Yoshiki; Nakamura, Kimitoshi; Hattori, Kiyoko; Nagamatsu, Kiyoshiro; Shimizu, Yusaku; Yasude, Takuji; Ushiyama, Masao; Endo, Fumio; Fukushima, Yoshimitsu; Ikeda, Shu-ichi
    JOURNAL OF HUMAN GENETICS, 55(4), 259-261, Apr. 2010, RefereedWebofScienceリポジトリ電子ジャーナル
  • Successful pregnancy and lactation outcome in a patient with Gaucher disease receiving enzyme replacement therapy: distribution and excretion of imiglucerase in human milk
    Sekijima Y, Ohashi T, Ohira S, Kosho T, Fukushima Y
    Clin Ther, 32(12), 2048-2052, 2010, RefereedWebofScienceリポジトリ電子ジャーナル
  • CPPD crystal deposition disease of the cervical spine: A common cause of acute neck pain encountered in the neurology department
    Sekijima Y, Yoshida T, Ikeda SI
    J Neurol Sci, 296(1-2), 79-82, 2010, RefereedWebofScienceリポジトリ電子ジャーナル
  • 蛋白質ミスフォールディング病の発症機序と治療戦略
    信州医学雑誌, 56(3), 115-124, 2008リポジトリ電子ジャーナル
  • Benign intracranial hypertension and leukoencephalopathy due to venous sinus stenosis in an SLE patient
    Yasude, T; Sekijima, Y; Mitsuhashi, S; Gono, T; Matsuda, M; Ikeda, S
    Lupus, 16(10), 839-840, 2007, RefereedWebofScienceリポジトリ電子ジャーナル
  • アルツハイマー病 原因と危険因子
    からだの科学, 218, 41-47, 2001
  • Serum transthyretin monomer in patients with familial amyloid polyneuropathy
    Sekijima, Y; Tokuda, T; Kametani, F; Tanaka, K; Maruyama, K; Ikeda, S
    AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 8(4), 257-262, 2001, RefereedWebofScience
  • Three patients with isolated adrenocorticotropin deficiency presenting with neuroleptic malignant syndrome-like symptoms
    Sekijima, Y; Hoshi, K; Kasai, H; Okada, M; Namiki, S; Ohta, K; Nakano, T; Hirayama, J; Ikeda, S
    INTERNAL MEDICINE, 40(6), 510-514, 2001, RefereedWebofScience
  • Amyloid beta protein species in cerebrospinal fluid and in brain from patients with Down's syndrome
    Tamaoka, A; Sekijima, Y; Masuno, S; Tokuda, T; Shoji, S; Ikeda, SI
    ANNALS OF NEUROLOGY, 46(6), 933-933, 1999, RefereedWebofScience
  • Presenilin-1 exists in the axoplasm fraction in the brains of aged Down's syndrome subjects and non-demented individuals
    Sekijima, Y; Kametani, F; Tanaka, K; Okochi, M; Usami, M; Mori, H; Tokuda, T; Ikeda, S
    NEUROSCIENCE LETTERS, 267(2), 121-124, 1999, RefereedWebofScience
  • Sleep apnoea of central origin in a case of myotonic dystrophy
    Sekijima, Y; Morita, H; Hashimoto, T; Yamazaki, M; Yanagisawa, N
    JOURNAL OF CLINICAL NEUROSCIENCE, 5(1), 112-115, 1998, RefereedWebofScience電子ジャーナル
  • Prevalence of dementia of Alzheimer type and apolipoprotein E phenotypes in aged patients with Down's syndrome
    Sekijima, Y; Ikeda, S; Tokuda, T; Satoh, S; Hidaka, H; Hidaka, E; Ishikawa, M; Yanagisawa, N
    EUROPEAN NEUROLOGY, 39(4), 234-237, 1998, RefereedWebofScience電子ジャーナル
  • Hereditary motor and sensory neuropathy associated with cerebellar atrophy (HMSNCA): Clinical and neuropathological features of a Japanese family
    Sekijima, Y; Ohara, S; Nakagawa, S; Tabata, K; Yoshida, K; Ishigame, H; Shimizu, Y; Yanagisawa, N
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 158(1), 30-37, 1998, RefereedWebofScience電子ジャーナル
  • Serial magnetic resonance imaging (MRI) study of a patient with Balo's concentric sclerosis treated with immunoadsorption plasmapheresis
    Y. Sekijima, T. Tokuda T, T. Hashimoto 他3名
    Mult. Scler, 2, 291-294, 1997, Refereed
  • Follow-up of sarin poisoning in Matsumoto
    Sekijima, Y; Morita, H; Yanagisawa, N
    ANNALS OF INTERNAL MEDICINE, 127(11), 1042-1042, 1997, RefereedWebofScience

Research Themes

  • ATTRアミロイドーシスを代表とするアミロイドーシス・タンパク質ミスフォールディング病の病態解明及び治療法開発