TOMITA Takuro
Academic Assembly School of Medicine and Health Sciences Institute of Medicine
School of Medicine Department of Molecular Pharmacology
Associate Professor
Researcher Information
Research activity information
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Paper
- Development of a Novel Therapeutic for Pediatric Heart Failure Targeting Angiotensin II Receptor
Hiroyuki Kawagishi; Takero Nakajima; Risa Ramadhiani; Tsutomu Nakada; Takuro Tomita; Yasunari Kanda; Noriaki Emoto; Mitsuhiko Yamada
YAKUGAKU ZASSHI, 145(4), 275-280, Apr. 2025
- A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery.
Takashi Murayama; Nagomi Kurebayashi; Takuro Numaga-Tomita; Takuya Kobayashi; Satoru Okazaki; Kyosuke Yamashiro; Tsutomu Nakada; Shuichi Mori; Ryosuke Ishida; Hiroyuki Kagechika; Mitsuhiko Yamada; Takashi Sakurai
The Journal of general physiology, 154(12), Dec. 2022 - Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors.
Sayaka Oda; Kazuhiro Nishiyama; Yuka Furumoto; Yohei Yamaguchi; Akiyuki Nishimura; Xiaokang Tang; Yuri Kato; Takuro Numaga-Tomita; Toshiyuki Kaneko; Supachoke Mangmool; Takuya Kuroda; Reishin Okubo; Makoto Sanbo; Masumi Hirabayashi; Yoji Sato; Yasuaki Nakagawa; Koichiro Kuwahara; Ryu Nagata; Gentaro Iribe; Yasuo Mori; Motohiro Nishida
Nature communications, 13(1), 6374-6374, Oct. 2022 - Inhibition of transient receptor potential cation channel 6 promotes capillary arterialization during post-ischaemic blood flow recovery.
Takuro Numaga-Tomita; Tsukasa Shimauchi; Yuri Kato; Kazuhiro Nishiyama; Akiyuki Nishimura; Kosuke Sakata; Hiroyuki Inada; Satomi Kita; Takahiro Iwamoto; Junichi Nabekura; Lutz Birnbaumer; Yasuo Mori; Motohiro Nishida
British journal of pharmacology, 180(1), 94-110, Sep. 2022 - A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia.
Tsukasa Shimauchi; Takuro Numaga-Tomita; Yuri Kato; Hiroyuki Morimoto; Kosuke Sakata; Ryosuke Matsukane; Akiyuki Nishimura; Kazuhiro Nishiyama; Atsushi Shibuta; Yutoku Horiuchi; Hitoshi Kurose; Sang Geon Kim; Yasuteru Urano; Takashi Ohshima; Motohiro Nishida
Cells, 11(13), Jun. 2022 - Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart
Hiroyuki Kawagishi; Tsutomu Nakada; Takuro Numaga-Tomita; Maite Larrañaga; Ang Guo; Long-Sheng Song; Mitsuhiko Yamada
American Journal of Physiology-Heart and Circulatory Physiology, May 2022, Refereed - NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca2+ Homeostasis.
Hideaki Inazumi; Koichiro Kuwahara; Yasuaki Nakagawa; Yoshihiro Kuwabara; Takuro Numaga-Tomita; Toshihide Kashihara; Tsutomu Nakada; Nagomi Kurebayashi; Miku Oya; Miki Nonaka; Masami Sugihara; Hideyuki Kinoshita; Kenji Moriuchi; Hiromu Yanagisawa; Toshio Nishikimi; Hirohiko Motoki; Mitsuhiko Yamada; Sachio Morimoto; Kinya Otsu; Richard M Mortensen; Kazuwa Nakao; Takeshi Kimura
Circulation research, 130(2), 234-248, Dec. 2021 - Gravity sensing in plant and animal cells
Ken Takahashi; Hideyuki Takahashi; Takuya Furuichi; Masatsugu Toyota; Makoto Furutani-Seiki; Takeshi Kobayashi; Haruko Watanabe-Takano; Masahiro Shinohara; Takuro Numaga-Tomita; Asako Sakaue-Sawano; Atsushi Miyawaki; Keiji Naruse
npj Microgravity, 7(1), Dec. 2021 - β-Arrestin-Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate.
Toshihide Kashihara; Hiroyuki Kawagishi; Tsutomu Nakada; Takuro Numaga-Tomita; Shin Kadota; Elena E Wolf; Cheng-Kun Du; Yuji Shiba; Sachio Morimoto; Mitsuhiko Yamada
JACC. Basic to translational science, 5(11), 1057-1069, Nov. 2020 - TRPC Channels in Cardiac Plasticity
Numaga-Tomita T, Nishida M.
., 9, 454, Feb. 2020 - TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN.
Takuro Numaga-Tomita; Tsukasa Shimauchi; Sayaka Oda; Tomohiro Tanaka; Kazuhiro Nishiyama; Akiyuki Nishimura; Lutz Birnbaumer; Yasuo Mori; Motohiro Nishida
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(9), 9785-9796, Sep. 2019, Refereed - Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes.
Kazuhiro Nishiyama; Takuro Numaga-Tomita; Yasuyuki Fujimoto; Tomohiro Tanaka; Chiemi Toyama; Akiyuki Nishimura; Tomohiro Yamashita; Naoya Matsunaga; Satoru Koyanagi; Yasu-Taka Azuma; Yuko Ibuki; Koji Uchida; Shigehiro Ohdo; Motohiro Nishida
British journal of pharmacology, 176(18), 3723-3738, Sep. 2019, Refereed - TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy.
Suhaini Binti Sudi; Tomohiro Tanaka; Sayaka Oda; Kazuhiro Nishiyama; Akiyuki Nishimura; Caroline Sunggip; Supachoke Mangmool; Takuro Numaga-Tomita; Motohiro Nishida
Scientific reports, 9(1), 9785-9785, Jul. 2019, Refereed - Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload.
Akiyuki Nishimura; Kakeru Shimoda; Tomohiro Tanaka; Takashi Toyama; Kazuhiro Nishiyama; Yasuhiro Shinkai; Takuro Numaga-Tomita; Daiju Yamazaki; Yasunari Kanda; Takaaki Akaike; Yoshito Kumagai; Motohiro Nishida
Science signaling, 12(587), Jun. 2019, Refereed - TRPC channels in exercise-mimetic therapy.
Takuro Numaga-Tomita; Sayaka Oda; Kazuhiro Nishiyama; Tomohiro Tanaka; Akiyuki Nishimura; Motohiro Nishida
Pflugers Archiv : European journal of physiology, 471(3), 507-517, Mar. 2019, Refereed - Mitochondrial dynamics in exercise physiology.
Tomohiro Tanaka; Akiyuki Nishimura; Kazuhiro Nishiyama; Takumi Goto; Takuro Numaga-Tomita; Motohiro Nishida
Pflugers Archiv : European journal of physiology, Feb. 2019, Refereed - Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence.
Nishimura A; Shimauchi T; Tanaka T; Shimoda K; Toyama T; Kitajima N; Ishikawa T; Shindo N; Numaga-Tomita T; Yasuda S; Sato Y; Kuwahara K; Kumagai Y; Akaike T; Ide T; Ojida A; Mori Y; Nishida M
Science Signaling, 11(556), eaat5185, Nov. 2018, Refereed
- TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice.
Oda S, Numaga-Tomita T, Kitajima N, Toyama T, Harada E, Shimauchi T, Nishimura A, Ishikawa T, Kumagai Y, Birnbaumer L, Nishida M.
Sci Rep, 7, 7511, Aug. 2018 - TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes
Yohei Yamaguchi; Gentaro Iribe; Toshiyuki Kaneko; Ken Takahashi; Takuro Numaga-Tomita; Motohiro Nishida; Lutz Birnbaumer; Keiji Naruse
Journal of Physiological Sciences, 68(2), 153-164, Mar. 2018, Refereed - TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy.
Caroline Sunggip; Kakeru Shimoda; Sayaka Oda; Tomohiro Tanaka; Kazuhiro Nishiyama; Supachoke Mangmool; Akiyuki Nishimura; Takuro Numaga-Tomita; Motohiro Nishida
Frontiers in pharmacology, 9, 523-523, 2018, Refereed - [New Strategies for Exercise-Mimetic Medication].
Oda S; Numaga-Tomita T; Nishida M
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 138(10), 1257-1262, 2018, Refereed - Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases
Akiyuki Nishimura; Caroline Sunggip; Sayaka Oda; Takuro Numaga-Tomita; Makoto Tsuda; Motohiro Nishida
PHARMACOLOGY & THERAPEUTICS, 180, 113-128, Dec. 2017, Refereed - TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy.
Shimauchi T; Numaga-Tomita T; Ito T; Nishimura A; Matsukane R; Oda S; Hoka S; Ide T; Koitabashi N; Uchida K; Sumimoto H; Mori Y; Nishida M
JCI insight, 2(15), Aug. 2017, Refereed - TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice
Sayaka Oda; Takuro Numaga-Tomita; Naoyuki Kitajima; Takashi Toyama; Eri Harada; Tsukasa Shimauchi; Akiyuki Nishimura; Tatsuya Ishikawa; Yoshito Kumagai; Lutz Birnbaumer; Motohiro Nishida
SCIENTIFIC REPORTS, 7(1), 7511, Aug. 2017, Refereed - The functions of store-operated calcium channels
James W. Putney; Natacha Steinckwich-Besancon; Takuro Numaga-Tomita; Felicity M. Davis; Pooja N. Desai; Diane M. D'Agostin; Shilan Wu; Gary S. Bird
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1864(6), 900-906, Jun. 2017, Refereed - Purinergic P2Y(6) receptors: A new therapeutic target of age-dependent hypertension
Caroline Sunggip; Akiyuki Nishimura; Kakeru Shimoda; Takuro Numaga-Tomita; Makoto Tsuda; Motohiro Nishida
PHARMACOLOGICAL RESEARCH, 120, 51-59, Jun. 2017, Refereed - TRPC3 Channels in Cardiac Fibrosis.
Numaga-Tomita T; Oda S; Shimauchi T; Nishimura A; Mangmool S; Nishida M
Frontiers in cardiovascular medicine, 4, 56, 2017, Refereed - TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis
Takuro Numaga-Tomita; Naoyuki Kitajima; Takuya Kuroda; Akiyuki Nishimura; Kei Miyano; Satoshi Yasuda; Koichiro Kuwahara; Yoji Sato; Tomomi Ide; Lutz Birnbaumer; Hideki Sumimoto; Yasuo Mori; Motohiro Nishida
SCIENTIFIC REPORTS, 6, 39383, Dec. 2016, Refereed - TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling
Naoyuki Kitajima; Takuro Numaga-Tomita; Masahiko Watanabe; Takuya Kuroda; Akiyuki Nishimura; Kei Miyano; Satoshi Yasuda; Koichiro Kuwahara; Yoji Sato; Tomomi Ide; Lutz Birnbaumer; Hideki Sumimoto; Yasuo Mori; Motohiro Nishida
SCIENTIFIC REPORTS, 6, 37001, Nov. 2016, Refereed - TRPC3 amplifies B-cell receptor-induced ERK signalling via protein kinase D-dependent Rap1 activation
Takuro Numaga-Tomita; Motohiro Nishida; James W. Putney; Yasuo Mori
BIOCHEMICAL JOURNAL, 473(2), 201-210, Jan. 2016, Refereed - Purinergic P2Y(6) receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension
Akiyuki Nishimura; Caroline Sunggip; Hidetoshi Tozaki-Saitoh; Tsukasa Shimauchi; Takuro Numaga-Tomita; Katsuya Hirano; Tomomi Ide; Jean-Marie Boeynaems; Hitoshi Kurose; Makoto Tsuda; Bernard Robaye; Kazuhide Inoue; Motohiro Nishida
SCIENCE SIGNALING, 9(411), ra7, Jan. 2016, Refereed - Establishment of a Novel Therapeutic Strategy for Heart Failure Based on the Mechanism Underlying Maintenance of Redox Homeostasis by Reactive Sulfur Species
Motohiro Nishida; Takashi Toyama; Yoshito Kumagai; Takuro Numaga-Tomita
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 134(12), 1239-1243, Dec. 2014, Refereed - Role of STIM1-and Orai1-mediated Ca2+ entry in Ca2+-induced epidermal keratinocyte differentiation
Takuro Numaga-Tomita; James W. Putney
JOURNAL OF CELL SCIENCE, 126(2), 605-612, Jan. 2013, Refereed - Deletion of Orai1 alters expression of multiple genes during osteoclast and osteoblast maturation
Sung-Yong Hwang; Julie Foley; Takuro Numaga-Tomita; John G. Petranka; Gary S. Bird; James W. Putney
CELL CALCIUM, 52(6), 488-500, Dec. 2012, Refereed - Alternative translation initiation gives rise to two isoforms of Orai1 with distinct plasma membrane mobilities
Miwako Fukushima; Takuro Tomita; Agnes Janoshazi; James W. Putney
JOURNAL OF CELL SCIENCE, 125(18), 4354-4361, Sep. 2012, Refereed - Direct Observation of Protein Microcrystals in Crystallization Buffer by Atmospheric Scanning Electron Microscopy
Yuusuke Maruyama; Tatsuhiko Ebihara; Hidetoshi Nishiyama; Yuji Konyuba; Miki Senda; Takuro Numaga-Tomita; Toshiya Senda; Mitsuo Suga; Chikara Sato
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 13(8), 10553-10567, Aug. 2012, Refereed - Phospholipase C signaling and calcium influx.
Putney JW; Tomita T
Advances in biological regulation, 52(1), 152-164, Jan. 2012, Refereed - Activation and regulation of store-operated calcium entry
Jeremy T. Smyth; Sung-Yong Hwang; Takuro Tomita; Wayne I. DeHaven; Jason C. Mercer; James W. Putney
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 14(10), 2337-2349, Oct. 2010, Refereed - Ca2+ influx and protein scaffolding via TRPC3 sustain PKC beta and ERK activation in B cells
Takuro Numaga; Motohiro Nishida; Shigeki Kiyonaka; Kenta Kato; Masahiro Katano; Emiko Mori; Tomohiro Kurosaki; Ryuji Inoue; Masaki Hikida; James W. Putney; Yasuo Mori
JOURNAL OF CELL SCIENCE, 123(6), 927-938, Mar. 2010, Refereed - Store operated calcium entry in NIH-3T3 cells.
Tomita T; Bird GS; Putney JW
Journal of Medical Investigation, 56, 381-382, Dec. 2009 - A Pathogenic C Terminus-truncated Polycystin-2 Mutant Enhances Receptor-activated Ca2+ Entry via Association with TRPC3 and TRPC7
Kyoko Miyagi; Shigeki Kiyonaka; Kazunori Yamada; Takafumi Miki; Emiko Mori; Kenta Kato; Tomohiro Numata; Yuichi Sawaguchi; Takuro Numaga; Toru Kimura; Yoshikatsu Kanai; Mitsuhiro Kawano; Minoru Wakamori; Hideki Nomura; Ichiro Koni; Masakazu Yamagishi; Yasuo Mori
JOURNAL OF BIOLOGICAL CHEMISTRY, 284(49), 34400-34412, Dec. 2009, Refereed - TRPC channels function independently of STIM1 and Orai1
Wayne I. DeHaven; Bertina F. Jones; John G. Petranka; Jeremy T. Smyth; Takuro Tomita; Gary S. Bird; James W. Putney
JOURNAL OF PHYSIOLOGY-LONDON, 587(10), 2275-2298, May 2009, Refereed - Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound
Shigeki Kiyonaka; Kenta Kato; Motohiro Nishida; Kazuhiro Mio; Takuro Numaga; Yuichi Sawaguchi; Takashi Yoshida; Minoru Wakamori; Emiko Mori; Tomohiro Numata; Masakazu Ishii; Hiroki Takemoto; Akio Ojida; Kenta Watanabe; Aya Uemura; Hitoshi Kurose; Takashi Morii; Tsutomu Kobayashi; Yoji Sato; Chikara Sato; Itaru Hamachi; Yasuo Mori
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(13), 5400-5405, Mar. 2009, Refereed - Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum
Yoshihiro Baba; Kenji Hayashit; Yoko Fujii; Akiko Mizushima; Hiroshi Watarai; Minoru Wakamori; Takuro Numaga; Yasuo Mori; Masamitsu Iino; Masaki Hikida; Tomohiro Kurosaki
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(45), 16704-16709, Nov. 2006, Refereed - The role of canonical transient receptor potential 7 in B-cell receptor-activated channels
JP Lievremont; T Numaga; G Vazquez; L Lemonnier; Y Hara; E Mori; M Trebak; SE Moss; GS Bird; Y Mori; JW Putney
JOURNAL OF BIOLOGICAL CHEMISTRY, 280(42), 35346-35351, Oct. 2005, Refereed - Arabidopsis TOBAMOVIRUS MULTIPLICATION (TOM) 2 locus encodes a transmembrane protein that interacts with TOM1
Y Tsujimoto; T Numaga; K Ohshima; M Yano; R Ohsawa; DB Goto; S Niato; M Ishikawa
EMBO JOURNAL, 22(2), 335-343, Jan. 2003, Refereed - 末梢循環障害の創薬標的としてのTRPC6チャネル阻害の可能性
冨田 拓郎
信州医学雑誌, 72(2), 77-85, Refereed
Lead - Activation and regulation of store-operated calcium entry
Jeremy T. Smyth; Sung-Yong Hwang; Takuro Tomita; Wayne I. DeHaven; Jason C. Mercer; James W. Putney
MISC
- マウス下肢虚血後の毛細血管動脈化におけるTRPC6チャネルの役割
酒田 康介; 島内 司; 冨田 拓郎; 加藤 百合; 西山 和宏; 西村 明幸; 西田 基宏
日本薬学会年会要旨集, 142年会, 26K - am05S, Mar. 2022 - TRPC Channels in Cardiac Plasticity
Takuro Numaga-Tomita; Motohiro Nishida
Cells, 9(2), 17 Feb. 2020 - アンジオテンシンII1型受容体-βアレスチン経路を活性化する小児心不全治療薬の開発
川岸裕幸; 柏原俊英; 冨田拓郎; 中田勉; 山田充彦
日本循環薬理学会口演要旨集, 30th, 2020 - Molecular mechanisms underlying the agonistic effect of FPL 64176 on Cav1.2 Ca2+ channels
冨田拓郎; 五味志文; 柏原俊英; 中田勉; 山田充彦
日本薬理学雑誌, 155(Supplement), 2020 - βアレスチンバイアスアンジオテンシン1型受容体アゴニストは,新生児特有の持続性陽性変力作用を示す
川岸裕幸; 川岸裕幸; 柏原俊英; 冨田拓郎; 中田勉; 山田充彦
日本薬理学雑誌, 155(Supplement), 2020 - βアレスチンバイアスアンジオテンシン1型受容体アゴニストは,新生児マウス心臓において持続的な陽性変力作用を示す
川岸裕幸; 川岸裕幸; 柏原俊英; 中田勉; 冨田拓郎; 山田充彦
日本循環薬理学会口演要旨集, 29th, 2019
Lectures, oral presentations, etc.
- Analysis of molecular mechanism underlying STIM1-mediated suppression of CaV1.2
Takuro Numaga-Tomita
第101回日本生理学会大会, 30 Mar. 2024The importance of sympathetic innervation for the postnatal heart development
Takuro Numaga-Tomita; Hiroyuki Kawagshi; Tsutomu Nakada; Mitsuhiko Yamada
第100回日本生理学会大会, Mar. 2023The Importance of C-terminal Tyrosine Phosphorylation of CaV1.2 in Pathological Vascular Remodeling
Takuro Numaga-Tomita
第130回日本解剖学会・第102回日本生理学会・第98回日本薬理学会 合同大会, Mar. 2023Pathophysiological importance of C-terminal tyrosine phosphorylation of CaV1.2 in vessel remodeling
Takuro Numaga-Tomita
第96回日本薬理学会年会, Dec. 2022Molecular mechanism configuring CaV1.2 Ca2+ channel current in cardiac ventricular action potential.
Takuro Numaga-Tomita
第99回日本生理学会大会, Mar. 2022交感神経除神経が新生児・乳児の心臓発達に与える影響の解析
冨田(沼賀)拓郎
第31回日本循環薬理学会, Dec. 2021,The effect of chemical sympathetic innervation on the postnatal heart development
冨田(沼賀) 拓郎
第94回日本薬理学会年会, Mar. 2021血管平滑筋細胞におけるL型電位依存性カルシウムチャネルとストア作動性カルシウムチャネルの 関係性解明
冨田(沼賀) 拓郎
第30回日本循環薬理学会, Nov. 2020血管平滑筋の表現型スイッチにおけるTRPC6チャネルの重要性の解明
冨田(沼賀) 拓郎
第29回日本循環薬理学会, Nov. 2019,Importance of TRPC3-Nox2 Coupling in Cardiac Stiffness
Takuro Numaga-Tomita
8th International Workshop Cardiac Mechano-Electric Coupling and Arrhythmias, Sep. 2019, Invited病的心臓リモデリングにおけるTRPC3-Nox2の 機能連関の重要性の解明
冨田拓郎
第95回日本生理学会大会, Mar. 2018筋組織恒常性維持を目指したTRPC-Nox機能連関を標的とする創薬研究
冨田拓郎
日本薬学会第138年会, Mar. 2018, InvitedCa2+ signaling:Positive regulation of Nox2 by TRPC3 channel mediates mechanical stress-induced cardiac fibrosis
Takuro Numata-Tomita
KSC symposium 2017, Apr. 2017, Invited