博士（学術）, 総研大

Life sciences, Medical biochemistry

Life sciences, Dermatology

Life, health and medical informatics, molecular and cellular biology

2022
第96回日本薬理学会年会, 優秀ポスター賞

2019
日本生理学会, 入澤宏・彩記念若手研究奨励賞

2017
日本NO学会, Young Investigator Award
冨田拓郎

2016
International and Interdisciplinary symposium 2016, Best Poster Award
冨田拓郎

2016
日本NO学会, トラベルアワード
冨田拓郎

A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery.
Takashi Murayama; Nagomi Kurebayashi; Takuro Numaga-Tomita; Takuya Kobayashi; Satoru Okazaki; Kyosuke Yamashiro; Tsutomu Nakada; Shuichi Mori; Ryosuke Ishida; Hiroyuki Kagechika; Mitsuhiko Yamada; Takashi Sakurai
The Journal of general physiology, 154(12), Dec. 2022

Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors.
Sayaka Oda; Kazuhiro Nishiyama; Yuka Furumoto; Yohei Yamaguchi; Akiyuki Nishimura; Xiaokang Tang; Yuri Kato; Takuro Numaga-Tomita; Toshiyuki Kaneko; Supachoke Mangmool; Takuya Kuroda; Reishin Okubo; Makoto Sanbo; Masumi Hirabayashi; Yoji Sato; Yasuaki Nakagawa; Koichiro Kuwahara; Ryu Nagata; Gentaro Iribe; Yasuo Mori; Motohiro Nishida
Nature communications, 13(1), 6374-6374, Oct. 2022

Inhibition of transient receptor potential cation channel 6 promotes capillary arterialization during post-ischaemic blood flow recovery.
Takuro Numaga-Tomita; Tsukasa Shimauchi; Yuri Kato; Kazuhiro Nishiyama; Akiyuki Nishimura; Kosuke Sakata; Hiroyuki Inada; Satomi Kita; Takahiro Iwamoto; Junichi Nabekura; Lutz Birnbaumer; Yasuo Mori; Motohiro Nishida
British journal of pharmacology, 180(1), 94-110, Sep. 2022

A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia.
Tsukasa Shimauchi; Takuro Numaga-Tomita; Yuri Kato; Hiroyuki Morimoto; Kosuke Sakata; Ryosuke Matsukane; Akiyuki Nishimura; Kazuhiro Nishiyama; Atsushi Shibuta; Yutoku Horiuchi; Hitoshi Kurose; Sang Geon Kim; Yasuteru Urano; Takashi Ohshima; Motohiro Nishida
Cells, 11(13), Jun. 2022

Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart
Hiroyuki Kawagishi; Tsutomu Nakada; Takuro Numaga-Tomita; Maite Larrañaga; Ang Guo; Long-Sheng Song; Mitsuhiko Yamada
American Journal of Physiology-Heart and Circulatory Physiology, May 2022, Refereed, Not invited

NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca2+ Homeostasis.
Hideaki Inazumi; Koichiro Kuwahara; Yasuaki Nakagawa; Yoshihiro Kuwabara; Takuro Numaga-Tomita; Toshihide Kashihara; Tsutomu Nakada; Nagomi Kurebayashi; Miku Oya; Miki Nonaka; Masami Sugihara; Hideyuki Kinoshita; Kenji Moriuchi; Hiromu Yanagisawa; Toshio Nishikimi; Hirohiko Motoki; Mitsuhiko Yamada; Sachio Morimoto; Kinya Otsu; Richard M Mortensen; Kazuwa Nakao; Takeshi Kimura
Circulation research, 130(2), 234-248, Dec. 2021

Gravity sensing in plant and animal cells
Ken Takahashi; Hideyuki Takahashi; Takuya Furuichi; Masatsugu Toyota; Makoto Furutani-Seiki; Takeshi Kobayashi; Haruko Watanabe-Takano; Masahiro Shinohara; Takuro Numaga-Tomita; Asako Sakaue-Sawano; Atsushi Miyawaki; Keiji Naruse
npj Microgravity, 7(1), Dec. 2021

β-Arrestin-Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate.
Toshihide Kashihara; Hiroyuki Kawagishi; Tsutomu Nakada; Takuro Numaga-Tomita; Shin Kadota; Elena E Wolf; Cheng-Kun Du; Yuji Shiba; Sachio Morimoto; Mitsuhiko Yamada
JACC. Basic to translational science, 5(11), 1057-1069, Nov. 2020

TRPC Channels in Cardiac Plasticity
Numaga-Tomita T, Nishida M.
., 9, 454, Feb. 2020

TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN.
Takuro Numaga-Tomita; Tsukasa Shimauchi; Sayaka Oda; Tomohiro Tanaka; Kazuhiro Nishiyama; Akiyuki Nishimura; Lutz Birnbaumer; Yasuo Mori; Motohiro Nishida
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(9), 9785-9796, Sep. 2019, Refereed, Not invited

Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes.
Kazuhiro Nishiyama; Takuro Numaga-Tomita; Yasuyuki Fujimoto; Tomohiro Tanaka; Chiemi Toyama; Akiyuki Nishimura; Tomohiro Yamashita; Naoya Matsunaga; Satoru Koyanagi; Yasu-Taka Azuma; Yuko Ibuki; Koji Uchida; Shigehiro Ohdo; Motohiro Nishida
British journal of pharmacology, 176(18), 3723-3738, Sep. 2019, Refereed, Not invited

TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy.
Suhaini Binti Sudi; Tomohiro Tanaka; Sayaka Oda; Kazuhiro Nishiyama; Akiyuki Nishimura; Caroline Sunggip; Supachoke Mangmool; Takuro Numaga-Tomita; Motohiro Nishida
Scientific reports, 9(1), 9785-9785, Jul. 2019, Refereed, Not invited

Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload.
Akiyuki Nishimura; Kakeru Shimoda; Tomohiro Tanaka; Takashi Toyama; Kazuhiro Nishiyama; Yasuhiro Shinkai; Takuro Numaga-Tomita; Daiju Yamazaki; Yasunari Kanda; Takaaki Akaike; Yoshito Kumagai; Motohiro Nishida
Science signaling, 12(587), Jun. 2019, Refereed, Not invited

TRPC channels in exercise-mimetic therapy.
Takuro Numaga-Tomita; Sayaka Oda; Kazuhiro Nishiyama; Tomohiro Tanaka; Akiyuki Nishimura; Motohiro Nishida
Pflugers Archiv : European journal of physiology, 471(3), 507-517, Mar. 2019, Refereed, Not invited

Mitochondrial dynamics in exercise physiology.
Tomohiro Tanaka; Akiyuki Nishimura; Kazuhiro Nishiyama; Takumi Goto; Takuro Numaga-Tomita; Motohiro Nishida
Pflugers Archiv : European journal of physiology, Feb. 2019, Refereed, Not invited

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence.
Nishimura A; Shimauchi T; Tanaka T; Shimoda K; Toyama T; Kitajima N; Ishikawa T; Shindo N; Numaga-Tomita T; Yasuda S; Sato Y; Kuwahara K; Kumagai Y; Akaike T; Ide T; Ojida A; Mori Y; Nishida M
Science Signaling, 11(556), eaat5185, Nov. 2018, Refereed, Not invited

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice.
Oda S, Numaga-Tomita T, Kitajima N, Toyama T, Harada E, Shimauchi T, Nishimura A, Ishikawa T, Kumagai Y, Birnbaumer L, Nishida M.
Sci Rep, 7, 7511, Aug. 2018

TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes
Yohei Yamaguchi; Gentaro Iribe; Toshiyuki Kaneko; Ken Takahashi; Takuro Numaga-Tomita; Motohiro Nishida; Lutz Birnbaumer; Keiji Naruse
Journal of Physiological Sciences, 68(2), 153-164, Mar. 2018, Refereed, Not invited

TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy.
Caroline Sunggip; Kakeru Shimoda; Sayaka Oda; Tomohiro Tanaka; Kazuhiro Nishiyama; Supachoke Mangmool; Akiyuki Nishimura; Takuro Numaga-Tomita; Motohiro Nishida
Frontiers in pharmacology, 9, 523-523, 2018, Refereed, Not invited

[New Strategies for Exercise-Mimetic Medication].
Oda S; Numaga-Tomita T; Nishida M
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 138(10), 1257-1262, 2018, Refereed, Not invited

Purinergic P2Y receptors: Molecular diversity and implications for treatment of cardiovascular diseases
Akiyuki Nishimura; Caroline Sunggip; Sayaka Oda; Takuro Numaga-Tomita; Makoto Tsuda; Motohiro Nishida
PHARMACOLOGY & THERAPEUTICS, 180, 113-128, Dec. 2017, Refereed, Not invited

TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy.
Shimauchi T; Numaga-Tomita T; Ito T; Nishimura A; Matsukane R; Oda S; Hoka S; Ide T; Koitabashi N; Uchida K; Sumimoto H; Mori Y; Nishida M
JCI insight, 2(15), Aug. 2017, Refereed, Not invited

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice
Sayaka Oda; Takuro Numaga-Tomita; Naoyuki Kitajima; Takashi Toyama; Eri Harada; Tsukasa Shimauchi; Akiyuki Nishimura; Tatsuya Ishikawa; Yoshito Kumagai; Lutz Birnbaumer; Motohiro Nishida
SCIENTIFIC REPORTS, 7(1), 7511, Aug. 2017, Refereed, Not invited

The functions of store-operated calcium channels
James W. Putney; Natacha Steinckwich-Besancon; Takuro Numaga-Tomita; Felicity M. Davis; Pooja N. Desai; Diane M. D'Agostin; Shilan Wu; Gary S. Bird
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1864(6), 900-906, Jun. 2017, Refereed, Not invited

Purinergic P2Y(6) receptors: A new therapeutic target of age-dependent hypertension
Caroline Sunggip; Akiyuki Nishimura; Kakeru Shimoda; Takuro Numaga-Tomita; Makoto Tsuda; Motohiro Nishida
PHARMACOLOGICAL RESEARCH, 120, 51-59, Jun. 2017, Refereed, Not invited

TRPC3 Channels in Cardiac Fibrosis.
Numaga-Tomita T; Oda S; Shimauchi T; Nishimura A; Mangmool S; Nishida M
Frontiers in cardiovascular medicine, 4, 56, 2017, Refereed, Not invited

TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis
Takuro Numaga-Tomita; Naoyuki Kitajima; Takuya Kuroda; Akiyuki Nishimura; Kei Miyano; Satoshi Yasuda; Koichiro Kuwahara; Yoji Sato; Tomomi Ide; Lutz Birnbaumer; Hideki Sumimoto; Yasuo Mori; Motohiro Nishida
SCIENTIFIC REPORTS, 6, 39383, Dec. 2016, Refereed, Not invited

TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling
Naoyuki Kitajima; Takuro Numaga-Tomita; Masahiko Watanabe; Takuya Kuroda; Akiyuki Nishimura; Kei Miyano; Satoshi Yasuda; Koichiro Kuwahara; Yoji Sato; Tomomi Ide; Lutz Birnbaumer; Hideki Sumimoto; Yasuo Mori; Motohiro Nishida
SCIENTIFIC REPORTS, 6, 37001, Nov. 2016, Refereed, Not invited

TRPC3 amplifies B-cell receptor-induced ERK signalling via protein kinase D-dependent Rap1 activation
Takuro Numaga-Tomita; Motohiro Nishida; James W. Putney; Yasuo Mori
BIOCHEMICAL JOURNAL, 473(2), 201-210, Jan. 2016, Refereed, Not invited

Purinergic P2Y(6) receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension
Akiyuki Nishimura; Caroline Sunggip; Hidetoshi Tozaki-Saitoh; Tsukasa Shimauchi; Takuro Numaga-Tomita; Katsuya Hirano; Tomomi Ide; Jean-Marie Boeynaems; Hitoshi Kurose; Makoto Tsuda; Bernard Robaye; Kazuhide Inoue; Motohiro Nishida
SCIENCE SIGNALING, 9(411), ra7, Jan. 2016, Refereed, Not invited

Establishment of a Novel Therapeutic Strategy for Heart Failure Based on the Mechanism Underlying Maintenance of Redox Homeostasis by Reactive Sulfur Species
Motohiro Nishida; Takashi Toyama; Yoshito Kumagai; Takuro Numaga-Tomita
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 134(12), 1239-1243, Dec. 2014, Refereed, Not invited

Role of STIM1-and Orai1-mediated Ca2+ entry in Ca2+-induced epidermal keratinocyte differentiation
Takuro Numaga-Tomita; James W. Putney
JOURNAL OF CELL SCIENCE, 126(2), 605-612, Jan. 2013, Refereed, Not invited

Deletion of Orai1 alters expression of multiple genes during osteoclast and osteoblast maturation
Sung-Yong Hwang; Julie Foley; Takuro Numaga-Tomita; John G. Petranka; Gary S. Bird; James W. Putney
CELL CALCIUM, 52(6), 488-500, Dec. 2012, Refereed, Not invited

Alternative translation initiation gives rise to two isoforms of Orai1 with distinct plasma membrane mobilities
Miwako Fukushima; Takuro Tomita; Agnes Janoshazi; James W. Putney
JOURNAL OF CELL SCIENCE, 125(18), 4354-4361, Sep. 2012, Refereed, Not invited

Direct Observation of Protein Microcrystals in Crystallization Buffer by Atmospheric Scanning Electron Microscopy
Yuusuke Maruyama; Tatsuhiko Ebihara; Hidetoshi Nishiyama; Yuji Konyuba; Miki Senda; Takuro Numaga-Tomita; Toshiya Senda; Mitsuo Suga; Chikara Sato
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 13(8), 10553-10567, Aug. 2012, Refereed, Not invited

Phospholipase C signaling and calcium influx.
Putney JW; Tomita T
Advances in biological regulation, 52(1), 152-164, Jan. 2012, Refereed, Not invited

Activation and regulation of store-operated calcium entry
Jeremy T. Smyth; Sung-Yong Hwang; Takuro Tomita; Wayne I. DeHaven; Jason C. Mercer; James W. Putney
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 14(10), 2337-2349, Oct. 2010, Refereed, Not invited

Ca2+ influx and protein scaffolding via TRPC3 sustain PKC beta and ERK activation in B cells
Takuro Numaga; Motohiro Nishida; Shigeki Kiyonaka; Kenta Kato; Masahiro Katano; Emiko Mori; Tomohiro Kurosaki; Ryuji Inoue; Masaki Hikida; James W. Putney; Yasuo Mori
JOURNAL OF CELL SCIENCE, 123(6), 927-938, Mar. 2010, Refereed, Not invited

Store operated calcium entry in NIH-3T3 cells.
Tomita T; Bird GS; Putney JW
Journal of Medical Investigation, 56, 381-382, Dec. 2009, Not invited

A Pathogenic C Terminus-truncated Polycystin-2 Mutant Enhances Receptor-activated Ca2+ Entry via Association with TRPC3 and TRPC7
Kyoko Miyagi; Shigeki Kiyonaka; Kazunori Yamada; Takafumi Miki; Emiko Mori; Kenta Kato; Tomohiro Numata; Yuichi Sawaguchi; Takuro Numaga; Toru Kimura; Yoshikatsu Kanai; Mitsuhiro Kawano; Minoru Wakamori; Hideki Nomura; Ichiro Koni; Masakazu Yamagishi; Yasuo Mori
JOURNAL OF BIOLOGICAL CHEMISTRY, 284(49), 34400-34412, Dec. 2009, Refereed, Not invited

TRPC channels function independently of STIM1 and Orai1
Wayne I. DeHaven; Bertina F. Jones; John G. Petranka; Jeremy T. Smyth; Takuro Tomita; Gary S. Bird; James W. Putney
JOURNAL OF PHYSIOLOGY-LONDON, 587(10), 2275-2298, May 2009, Refereed, Not invited

Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound
Shigeki Kiyonaka; Kenta Kato; Motohiro Nishida; Kazuhiro Mio; Takuro Numaga; Yuichi Sawaguchi; Takashi Yoshida; Minoru Wakamori; Emiko Mori; Tomohiro Numata; Masakazu Ishii; Hiroki Takemoto; Akio Ojida; Kenta Watanabe; Aya Uemura; Hitoshi Kurose; Takashi Morii; Tsutomu Kobayashi; Yoji Sato; Chikara Sato; Itaru Hamachi; Yasuo Mori
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(13), 5400-5405, Mar. 2009, Refereed, Not invited

Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum
Yoshihiro Baba; Kenji Hayashit; Yoko Fujii; Akiko Mizushima; Hiroshi Watarai; Minoru Wakamori; Takuro Numaga; Yasuo Mori; Masamitsu Iino; Masaki Hikida; Tomohiro Kurosaki
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(45), 16704-16709, Nov. 2006, Refereed, Not invited

The role of canonical transient receptor potential 7 in B-cell receptor-activated channels
JP Lievremont; T Numaga; G Vazquez; L Lemonnier; Y Hara; E Mori; M Trebak; SE Moss; GS Bird; Y Mori; JW Putney
JOURNAL OF BIOLOGICAL CHEMISTRY, 280(42), 35346-35351, Oct. 2005, Refereed, Not invited

Arabidopsis TOBAMOVIRUS MULTIPLICATION (TOM) 2 locus encodes a transmembrane protein that interacts with TOM1
Y Tsujimoto; T Numaga; K Ohshima; M Yano; R Ohsawa; DB Goto; S Niato; M Ishikawa
EMBO JOURNAL, 22(2), 335-343, Jan. 2003, Refereed, Not invited

Activation and regulation of store-operated calcium entry
Jeremy T. Smyth; Sung-Yong Hwang; Takuro Tomita; Wayne I. DeHaven; Jason C. Mercer; James W. Putney

マウス下肢虚血後の毛細血管動脈化におけるTRPC6チャネルの役割
酒田 康介; 島内 司; 冨田 拓郎; 加藤 百合; 西山 和宏; 西村 明幸; 西田 基宏
日本薬学会年会要旨集, 142年会, 26K - am05S, Mar. 2022

The importance of sympathetic innervation for the postnatal heart development
Takuro Numaga-Tomita; Hiroyuki Kawagshi; Tsutomu Nakada; Mitsuhiko Yamada
第100回日本生理学会大会, Mar. 2023

Pathophysiological importance of C-terminal tyrosine phosphorylation of CaV1.2 in vessel remodeling
Takuro Numaga-Tomita
第96回日本薬理学会年会, Dec. 2022, Not invited

Molecular mechanism configuring CaV1.2 Ca2+ channel current in cardiac ventricular action potential.
Takuro Numaga-Tomita
第99回日本生理学会大会, Mar. 2022, Not invited

交感神経除神経が新生児・乳児の心臓発達に与える影響の解析
冨田(沼賀)拓郎
第31回日本循環薬理学会, Dec. 2021, Not invited,

The effect of chemical sympathetic innervation on the postnatal heart development
冨田(沼賀) 拓郎
第94回日本薬理学会年会, Mar. 2021, Not invited

血管平滑筋細胞におけるL型電位依存性カルシウムチャネルとストア作動性カルシウムチャネルの 関係性解明
冨田(沼賀) 拓郎
第30回日本循環薬理学会, Nov. 2020, Not invited

血管平滑筋の表現型スイッチにおけるTRPC6チャネルの重要性の解明
冨田(沼賀) 拓郎
第29回日本循環薬理学会, Nov. 2019, Not invited,

Importance of TRPC3-Nox2 Coupling in Cardiac Stiffness
Takuro Numaga-Tomita
8th International Workshop Cardiac Mechano-Electric Coupling and Arrhythmias, Sep. 2019, Invited

病的心臓リモデリングにおけるTRPC3-Nox2の 機能連関の重要性の解明
冨田拓郎
第95回日本生理学会大会, Mar. 2018, Not invited

筋組織恒常性維持を目指したTRPC-Nox機能連関を標的とする創薬研究
冨田拓郎
日本薬学会第138年会, Mar. 2018, Invited

Ca2+ signaling:Positive regulation of Nox2 by TRPC3 channel mediates mechanical stress-induced cardiac fibrosis
Takuro Numata-Tomita
KSC symposium 2017, Apr. 2017, Invited

Functional and physical coupling between TRPC3 and Nox2 underlies maladaptive cardiac fibrosis.
Takuro Numata-Tomita
第94回日本生理学会大会, Mar. 2017, Not invited

Improvement of peripheral circulation after hindlimb ischemia by TRPC channel inhibition.
Takuro Numata-Tomita
第90回日本薬理学会年会, Mar. 2017, Not invited

The analysis of novel regulatory mechanisms and their physiological importances of L type voltage dependent calcium channels in circulatory tissues.