神吉 昭子 (カミヨシ アキコ)   

学術研究院(医学系)

先鋭領域融合研究群 バイオメディカル研究所 

助教 

学位

  • 博士(医学), 信州大学

研究分野

  • 実験動物学, 実験動物学

メールアドレス

    kamiyosh★shinshu-u.ac.jp

経歴

  • 2006年
    信州大学大学院医学系研究科 助教
  • 2005年 - 2006年
    長野県テクノ財団 研究員
  • 2005年 - 2005年
    信州大学大学院医学系研究科 奨励研究員
  • 2000年 - 2005年
    信州大学ヒト環境科学研究支援センター 研究支援推進員

学歴

  • 2000年, 東邦大学, 理学研究科, 生物分子科学専攻
  • 1998年, 東邦大学, 理学部, 生物分子科学科

論文

  • Receptor activity modifying protein RAMP sub-isoforms and their functional differentiation, which regulates functional diversity of adrenomedullin
    Shindo T, Tanaka M, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Sakurai T.
    Biology, 11(5), 788, 2022年05月
  • Adrenomedullin ameliorates pulmonary fibrosis by regulating TGF-β-Smads signaling and myofibroblast differentiation
    Wei Y, Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Cui N, Kakihara S, Zhao Y, Aruga K, Sanjo H, Shindo T.
    Endocrinology, 162(8), bqab090, 2021年08月
  • Adrenomedullin-Receptor Activity-Modifying Protein 2 System Ameliorates Subretinal Fibrosis by Suppressing Epithelial-Mesenchymal Transition in Age-Related Macular Degeneration
    Tanaka M, Kakihara S, Hirabayashi K, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Cui N, Wei Y, Zhao Y, Aruga K, Yamauchi A, Murata T, Shindo T.
    Am J Pathol, 191(4), 652-668, 2021年04月
  • Adrenomedullin-RAMP2 and -RAMP3 Systems Regulate Cardiac Homeostasis during Cardiovascular Stress
    Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Tanaka M, Wei Y, Kakihara S, Zhao Y, Aruga K, Kawagishi H, Nakada T, Yamada M, Shindo T.
    Endocrinology, 162(3), bqab001, 2021年03月
  • Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts
    Dai K, Tanaka M, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Cui N, Wei Y, Tanaka M, Kakihara S, Matsui S, Shindo T.
    Oncogene, 39(9), 1914-1930, 2020年02月
  • Production of genetically engineered mice with higher efficiency, lower mosaicism, and multiplexing capability using maternally expressed Cas9
    Sakurai T, Kamiyoshi A, Kawate H, Watanabe S, Sato M, Shindo T.
    Sci Rep, 10(1), 1091, 2020年01月
  • Endogenous Calcitonin Gene-Related Peptide Deficiency Exacerbates Postoperative Lymphedema by Suppressing Lymphatic Capillary Formation and M2 Macrophage Accumulation
    Matsui S, Tanaka M, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Dai K, Cui N, Wei Y, Tanaka M, Kakihara S, Nakamura K, Yamauchi A, Ishida K, Tanaka S, Kawamata M, Shindo T.
    Am J Pathol, 189(12), 2487-2502, 2019年12月
  • Bindel-PCR: a novel and convenient method for identifying CRISPR/Cas9-induced biallelic mutants through modified PCR using Thermus aquaticus DNA polymerase
    Sakurai T, Kamiyoshi A, Takei N, Watanabe S, Sato M, Shindo T.
    Sci Rep, 9(1), 9923, 2019年07月09日
  • Development of a Novel Model of Central Retinal Vascular Occlusion and the Therapeutic Potential of the Adrenomedullin-Receptor Activity-Modifying Protein 2 System
    Hirabayashi, Kazutaka; Tanaka, Masaaki; Imai, Akira; Toriyama, Yuichi; Iesato, Yasuhiro; Sakurai, Takayuki; Kamiyoshi, Akiko; Ichikawa-Shindo, Yuka; Kawate, Hisaka; Tanaka, Megumu; Dai, Kun; Cui, Nanqi; Wei, Yangxuan; Nakamura, Keisei; Iida, Shiho; Matsui, Shuhei; Yamauchi, Akihiro; Murata, Toshinori; Shindo, Takayuki;
    AMERICAN JOURNAL OF PATHOLOGY, 189(2), 449-466, 2019年02月WebofScience電子ジャーナル
  • Regulation of cardiovascular development and homeostasis by the adrenomedullin-RAMP system
    Shindo, Takayuki; Tanaka, Megumu; Kamiyoshi, Akiko; Ichikawa-Shindo, Yuka; Kawate, Hisaka; Yamauchi, Akihiro; Sakurai, Takayuki;
    PEPTIDES, 111, 55-61, 2019年01月WebofScience電子ジャーナル
  • RAMP3 deficiency enhances postmenopausal obesity and metabolic disorders
    Liu, Teng; Kamiyoshi, Akiko; Tanaka, Megumu; Iida, Shiho; Sakurai, Takayuki; Ichikawa-Shindo, Yuka; Kawate, Hisaka; Hirabayashi, Kazutaka; Dai, Kun; Cui, Nanqi; Tanaka, Masaaki; Wei, Yangxuan; Nakamura, Keisei; Matsui, Shuhei; Yamauchi, Akihiro; Shindo, Takayuki;
    PEPTIDES, 110, 10-18, 2018年12月WebofScience電子ジャーナル
  • Endogenous calcitonin gene-related peptide suppresses ischemic brain injuries and progression of cognitive decline.
    Zhai L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Xian X, Hirabayashi K, Dai K, Cui N, Tanimura K, Liu T, Wei Y, Tanaka M, Tomiyama H, Yamauchi A, Igarashi K, Shindo T.
    J Hypertens, 36(4), 876-891, 2018年04月電子ジャーナル
  • Placental extract ameliorates non-alcoholic steatohepatitis (NASH) by exerting protective effects on endothelial cells.
    Yamauchi A, Kamiyoshi A, Koyama T, Iinuma N, Yamaguchi S, Miyazaki H, Hirano E, Kaku T, Shindo T.
    Heliyon, 3(9), e00416, 2017年09月27日電子ジャーナル
  • Adrenomedullin Suppresses Vascular Endothelial Growth Factor-Induced Vascular Hyperpermeability and Inflammation in Retinopathy.
    Imai A, Toriyama Y, Iesato Y, Hirabayashi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Liu T, Xian X, Zhai L, Dai K, Tanimura K, Liu T, Cui N, Yamauchi A, Murata T, Shindo T.
    Am J Pathol, 187(5), 999-1015, 2017年05月電子ジャーナル
  • Vasoprotective Activities of the Adrenomedullin-RAMP2 System in Endothelial Cells.
    Xian X, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Tanaka M, Koyama T, Kawate H, Yang L, Liu T, Imai A, Zhai L, Hirabayashi K, Dai K, Tanimura K, Liu T, Cui N, Igarashi K, Yamauchi A, Shindo T.
    Endocrinology, 158(5), 1359-1372, 2017年05月電子ジャーナル
  • Endogenous Calcitonin Gene-Related Peptide Regulates Lipid Metabolism and Energy Homeostasis in Male Mice.
    Liu T, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Yang L, Tanaka M, Xian X, Imai A, Zhai L, Hirabayashi K, Dai K, Tanimura K, Liu T, Cui N, Igarashi K, Yamauchi A, Shindo T.
    Endocrinology, 158(5), 1194-1206, 2017年05月電子ジャーナル
  • A non-inheritable maternal Cas9-based multiple-gene editing system in mice
    Sakurai T, Kamiyoshi A, Kawate H, Mori C, Watanabe S, Tanaka M, Uetake R, Sato M, Shindo T
    Sci Rep, 6(20011), 2016年
  • The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumor metastasis
    Tanaka M, Koyama T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Liu T, Xian X, Imai A, Zhai L, Hirabayashi K, Owa S, Yamauchi A, Igarashi K, Taniguchi S, Shindo T
    Cardiovasc Res, 111(4), 398-409, 2016年
  • Pathophysiological Function of Endogenous Calcitonin Gene-Related Peptide in Ocular Vascular Diseases
    Toriyama Y, Iesato Y, Imai A, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Igarashi K, Tanaka M, Liu T, Xian X, Zhai L, Owa S, Murata T, Shindo T
    Am J Pathol, 185(6), 1783-94, 2015年
  • Adrenomedullin-RAMP2 System in Vascular Endothelial Cells
    Koyama T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Shindo T
    J Atheroscler Thromb, 22(7), 647-53, 2015年
  • A single blastocyst assay optimized for detecting CRISPR/Cas9 system-induced indel mutations in mice
    Sakurai T, Watanabe S, Kamiyoshi A, Sato M, Shindo T
    BMC Biotechnol, 14, 69, 2014年
  • Adrenomedullin-RAMP2 System Suppresses ER Stress-Induced Tubule Cell Death and Is Involved in Kidney Protection
    Uetake R, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Yoshizawa T, Koyama T, Yang L, Toriyama Y, Yamauchi A, Igarashi K, Tanaka M, Kuwabara T, Mori K, Yanagita M, Mukoyama M, Shindo T
    PLOS ONE, 9(2), e87667, 2014年
  • Pathophysiological roles of adrenomedullin-RAMP2 system in acute and chronic cerebral ischemia
    Igarashi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L. Owa S, Koyama T, Uetake R, Ihara M, Shindo T
    PEPTIDES, 62, 21-31, 2014年
  • Functional differentiation of RAMP2 and RAMP3 in their regulation of the vascular system
    Yamauchi A, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Igarashi K, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L, Owa S, Arai T, Shindo T
    J Mol Cell Cardiol, 77, 73-85, 2014年
  • Vascular Endothelial Adrenomedullin-RAMP2 System Is Essential for Vascular Integrity and Organ Homeostasis
    Koyama T, Ochoa-Callejero L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Arai T, Yoshizawa T, Iesato Y, Lei Y, Uetake R, Okimura A, Yamauchi A, Tanaka M, Igarashi K, Toriyama Y, Kawate H, Adams RH, Kawakami H, Mochizuki N, Martinez A, Shindo T
    Circulation, 127(7), 842-853, 2013年
  • Novel Regulation of Cardiac Metabolism and Homeostasis by the Adrenomedullin-Receptor Activity-Modifying Protein 2 System
    Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T
    Hypertension, 61(2), 341-351, 2013年
  • Endogenous CGRP protects against neointimal hyperplasia following wire-induced vascular injury
    Yang L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yoshizawa T, Koyama T, Iesato Y, Uetake R, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Shindo T
    J Mol Cell Cardiol, 59, 55-66, 2013年
  • Adrenomedullin-RAMP2 System Is Crucially Involved in Retinal Angiogenesis
    Iesato Y, Toriyama Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yoshizawa T, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Igarashi K, Murata T, Shindo T
    Am J Pathol, 182(6), 2380-2390, 2013年
  • Regulation of adrenomedullin and its family peptide by RAMP system--lessons from genetically engineered mice
    Shindo T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Shimoyama N, Iinuma N, Arai T, Miyagawa S
    Curr Protein Pept Sci, 14(5), 347-357, 2013年WebofScienceリポジトリ電子ジャーナル
  • Adrenomedullin-RAMP2 system in cardiovascular development and homeostasis
    Shindo T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y
    Current Hypertension Reviews, 7, 217-227, 2011年
  • Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling
    Arai T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Iesato Y, Koyama T, Yoshizawa T, Uetake R, Yamauchi A, Yang L, Kawate H, Ogawa S, Kobayashi A, Miyagawa S, Shindo T
    PEPTIDES, 32(9), 1855-1865, 2011年WebofScienceリポジトリ電子ジャーナル
  • Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver
    Iinuma N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Arai T, Yoshizawa T, Koyama T, Uetake R, Kawate H, Muto S, Tagawa Y, Miyagawa S, Shindo T
    PEPTIDES, 31(5), 865-871, 2010年WebofScienceリポジトリ電子ジャーナル
  • Endogenous a-calcitonin gene-related peptide mitigates liver fibrosis in chronic hepatitis induced byrepeated administration of concanavalin A
    Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Iinuma N, Kawate H, Yoshizawa T, Koyama T, Muto S, Shindo T
    Liver Int, 29(5), 642-649, 2009年
  • GPCRmodulator protein RAMP2 is essential for angiogenesis and vascular integrity
    Ichikawa-Shindo Y, Sakurai T, Kamiyoshi A, Kawate H, Iinuma N, Yoshizawa T, Koyama T, Fukuchi J, Iimuro S, Moriyama N, Kawakami H, Murata T, Kangawa K, Nagai R, Shindo T
    J Clin Invest, 118(1), 29-39, 2008年
  • Rapid zygosity determination in mice by SYBR Green real-time genomic PCR of a crude DNA solution
    Sakurai T, Kamiyoshi A, Watanabe S, Sato M, Shindo T
    Transgenic Res, 17(1), 149-155, 2008年
  • Endogenous alphaCGRP protects against concanavalin A-induced hepatitis in mice
    Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Fukuchi J, Kawate H, Muto S, Tagawa Y, Shindo T
    Biochem Biophys Res Commun, 343(1), 152-158, 2006年
  • Azelnidipine, a long-acting dihydropyridine calcium channel blocker, suppresses the development of cardiac hypertrophy and fibrosis in adrenomedullin knock out mice.
    Shindo T, Niu P, Kamiyoshi A, Sakurai T, Ichikawa Y, Iinuma N, Kawate H
    Circulation, 114(18), 13-13, 2006年WebofScience
  • Characterization of cytochrome P450 expression in murine embryonic stem cell-derived hepatic tissue system
    Tsutsui M, Ogawa S, Inada Y, Tomioka E, Kamiyoshi A, Tanaka S, Kishida T, Nishiyama M, Murakami M, Kuroda J, Hashikura Y, Miyagawa S, Satoh F, Shibata N, Tagawa Y
    Drug Metabolism and Disposition, 34(4), 696-701, 2006年WebofScience
  • Effect of zinc on hepatoprotectivity of a1-acid glycoprotein
    Kawase M, Kagaya N, Kamiyoshi A, Tagawa Y, Yagi K
    Biomedical Research on Trace Elements, 16(4), 299-301, 2005年
  • Suppression of cell death in primary rat hepatocytes by a1-acid glycoprotein
    Kagaya N, Kamiyoshi A, Tagawa Y, Akamatsu S, Isoda K, Kawase M, Yagi K
    J Biosci Bioeng, 99(1), 81-83, 2005年
  • Interaction of rubratoxin B with serum albumin
    Kagaya N, Kamiyoshi A, Tagawa Y, Nagashima H, Kawase M, Yagi K
    Mycotoxins, 55(1), 23-26, 2005年
  • Tea catechin, epigallocatechin-3-gallate, inhibits rubratoxin B-induced apoptosis of hepatocytes through MAPK p38 pathway
    Kagaya N, Kamiyoshi A, Tagawa Y, Nagashima H, Kawase M, Yagi K
    Mycotoxins, 55(1), 17-22, 2005年
  • Liver organogenesis from murine embryonic stem cells - A substitute system for an animal experiment
    Ogawa S, Tagawa Y, Kamiyoshi A, Motoyama H, Tsutsui M, Sato F, Nishiyama M, Nakayama J, Hashikura Y, Miyagawa S
    Hepatology, 42(4), 746A-747A, 2005年WebofScience
  • Crucial roles of mesodermal cell lineages in a murine embryonic stem cell-derived in vitro liver organogenesis system
    Ogawa S, Tagawa Y, Kamiyoshi A, Suzuki A, Nakayama J, Hashikura Y, Miyagawa S
    Stem Cells, 23(7), 903-913, 2005年WebofScience
  • Liver protection by bis(maltolato)zinc(II) complex
    Kawase M, Kagaya N, Akamatsu S, Kamiyoshi A, Muto S, Tagawa Y, Yagi K
    Exp Anim, 53(1), 1-9, 2004年
  • Novel function of rare catechin, epigallocatechin-3-(3"-O-methyl)gallate, against cold injury in primary rat hepatocytes
    Kagaya N, Hara Y, Saijo R, Kamiyoshi A, Tagawa Y, Kawase M, Yagi K
    J Biosci Bioeng, 96(6), 559-563, 2003年
  • Survival and function of mouse embryonic stem cell-derived cardiomyocytes in ectopic transplants
    Johkura K, Cui L, Suzuki A, Teng RF, Kamiyoshi A, Okamura S, Kubota S, Zhao X, Asanuma K, Okouchi Y, Ogiwara N, Tagawa Y, Sasaki K
    Cardiovascular Research, 58(2), 435-443, 2003年WebofScience

書籍等出版物

  • Medical Science Digest 48 6
    神吉昭子、桜井敬之、新藤隆行, エネルギー代謝制御におけるAM, AM2の機能分化と相互作用
    38-40 2022年06月
  • 細胞工学 35 1
    新藤隆行、桜井敬之、神吉昭子、新藤優佳、田中愛、小山晃英, アドレノメデュリン-RAMP2シグナル
    33-38 2016年
  • 血管 37 4
    神吉昭子、桜井敬之、河手久香、新藤優佳、植竹龍一、山内啓弘、五十嵐恭子、鳥山佑一、田中愛、劉甜、羨鮮、今井章、翟留玉、大和慎治、新藤隆行, アドレノメデュリン-RAMP2システムによる、白色脂肪、褐色脂肪の脂質、エネルギー代謝制御
    135-139 2014年
  • 信州医学雑誌 51
    田川陽一、神吉昭子, 再生医療の展望:再生医療と遺伝子工学-ES細胞の利用を例に-
    361-362 2003年

所属学協会

  • 日本循環器学会
  • 日本実験動物学会
  • 日本内分泌学会

共同研究・競争的資金等の研究課題

  • CGRPによる免疫反応制御と肝保護作用機序の解明
  • AM-RAMP2系による肝臓脂質代謝制御とメタボリックシンドロームにおける意義