瀧 伸介 (タキ シンスケ)
医学部 医学科 再生医科学教室
特任教授
研究者情報
研究キーワード
- サイトカイン, シグナル伝達, 転写因子, ヘルパーT細胞, 好塩基球, NK細胞, 自然リンパ球, 上皮内リンパ球
経歴
研究活動情報
論文
- Interleukin-3-dependent potentiation of IgE responsiveness in mouse basophils
Takuma Kitano, Kaho Togawa, Juri Takemori, Yuya Motoki, Keitaroh Kishida, Saotomo Itoh, Masaya Takamoto, Shinsuke Taki, Shigeaki Hida
Genes to Cells, 28, 226-236, 2023年, 査読有り
- Interferon regulatory factor-2 is required for the establishment of the gut intraepithelial T-cell compartment
Shigeo Tokumaru, Yuta Yamamoto, Kazuki Yoshizawa, Yuji Soejima, Hideki Sanjo, Shinsuke Taki
International Immunology, 35(5), 231-241, 2022年 - 2-Deoxy-d-glucose induces deglycosylation of proinflammatory cytokine receptors and strongly reduces immunological responses in mouse models of inflammation
Ikuno Uehara,Mitsuko Kajita, Atsuko Tanimura, Shigeaki Hida, Munehiko Onda, Zenya Naito, Shinsuke Taki, Nobuyuki Tanaka
Pharmacol Res Perspect, 10(2), e00940, 2022年, 査読有り - TAK1 Limits Death Receptor Fas-Induced Proinflammatory Cell Death in Macrophages
Maeda K, Nakayama J, Taki S, Sanjo H.
JOURNAL OF IMMUNOLOGY, 209(6), 1173-1179, 2022年 - Circulating T cells and resident non-T cells restrict type 2 innate lymphoid cell expansion in the small intestine
Yamamoto, Yuta; Yoshizawa, Kazuki; Takamoto, Masaya; Soejima, Yuji; Sanjo, Hideki; Taki, Shinsuke;
Biochemical and biophysical research communications, 618, 93-99, 2022年
最終著者, 責任著者
- Generation of a common innate lymphoid cell progenitor requires interferon regulatory factor 2
Okubo, Yohei; Tokumaru, Shigeo; Yamamoto, Yuta; Miyagawa, Shin-ichi; Sanjo, Hideki; Taki, Shinsuke;
INTERNATIONAL IMMUNOLOGY, 31(8), 489-498, 2019年08月 - Water intake increases mesenteric lymph flow and the total flux of albumin, long-chain fatty acids, and IL-22 in rats: New concept of absorption in jejunum.
Nagashio S, Ajima K, Maejima D, Sanjo H, Kajihara R, Hayashi M, Watanabe-Asaka T, Kaidoh M, Yokoyama Y, Taki S, Kawai Y, Ohhashi T
Am J Physiol Gastrointest Liver Physiol, 316, G155-G165, 2019年01月01日, 査読有り - 転写因子IRF-2の自然リンパ球分化への関与
瀧伸介
臨床免疫・アレルギー科, 72(5), 480-485, 2019年 - Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death
Sanjo, Hideki; Nakayama, Jun; Yoshizawa, Takahiro; Fehling, Hans Joerg; Akira, Shizuo; Taki, Shinsuke;
JOURNAL OF IMMUNOLOGY, 203(4), 783-788, 2019年 - Staphylococcal superantigen-like 12 activates murine bone marrow derived mast cells
Kobayashi, Masato; Kitano, Takuma; Nishiyama, Saishi; Sanjo, Hideki; Onozaki, Kikuo; Taki, Shinsuke; Itoh, Saotomo; Hida, Shigeaki;
Biochemical and biophysical research communications, 511(2), 350-355, 2019年 - Staphylococcal alpha-hemolysin does not induce cell damage in murine mast cells but it augments the degranulation induced by Fc epsilon RI cross-linking and ionomycin
Hayashi, Kazuhito; Itoh, Saotomo; Morikawa, Arisa; Onozaki, Kikuo; Taki, Shinsuke; Tsuji, Tsutomu; Hida, Shigeaki;
Biochemical and biophysical research communications, 508(1), 263-269, 2019年 - Conditional Deletion of TAK1 in T Cells Reveals a Pivotal Role of TCR alpha beta(+) Intraepithelial Lymphocytes in Preventing Lymphopenia-Associated Colitis
Sanjo, Hideki; Tokumaru, Shigeo; Akira, Shizuo; Taki, Shinsuke;
PLOS ONE, 10(7), 2015年
- IL-15とNK細胞の発生・分化・ホメオスタシス
瀧 伸介
臨床免疫・アレルギー科, 59, 140-146, 2013年 - IRF-2 regulates B-cell proliferation and antibody production through distinct mechanisms
Minamino, Kento; Takahara, Kazuhiko; Adachi, Takumi; Nagaoka, Koji; Iyoda, Tomonori; Taki, Shinsuke; Inaba, Kayo;
INTERNATIONAL IMMUNOLOGY, 24(9), 573-581, 2012年09月 - Differential Requirements for IRF-2 in Generation of CD1d-Independent T Cells Bearing NK Cell Receptors
Notake, Tsuyoshi; Horisawa, Shin; Sanjo, Hideki; Miyagawa, Shin-ichi; Hida, Shigeaki; Taki, Shinsuke;
JOURNAL OF IMMUNOLOGY, 188(10), 4838-4845, 2012年 - Critical role of Th17 cells in inflammation and neovascularization after ischaemia
Hata, Takeki; Takahashi, Masafumi; Hida, Shigeaki; Kawaguchi, Masanori; Kashima, Yuichiro; Usui, Fumitake; Morimoto, Hajime; Nishiyama, Akiyo; Izawa, Atsushi; Koyama, Jun; Iwakura, Yoichiro; Taki, Shinsuke; Ikeda, Uichi;
Cardiovascular Research, 90(2), 364-372, 2011年05月 - 活性化T細胞におけるNKレセプターの発現
野竹剛、瀧 伸介
臨床免疫・アレルギー科, 55, 475-482, 2011年 - IL-15-High-Responder Developing NK Cells Bearing Ly49 Receptors in IL-15(-/-) Mice
Yoshizawa, Katsumi; Nakajima, Shinsuke; Notake, Tsuyoshi; Miyagawa, Shin-Ichi; Hida, Shigeaki; Taki, Shinsuke;
JOURNAL OF IMMUNOLOGY, 187(10), 5162-5169, 2011年 - Potentiation of TLR9 responses for human naive B-cell growth through RP105 signaling
Yamazaki, Kazuko; Yamazaki, Takashi; Taki, Shinsuke; Miyake, Kensuke; Hayashi, Takuma; Ochs, Hans D.; Agematsu, Kazunaga;
Clinical Immunology, 135(1), 125-136, 2010年04月 - 好塩基球におけるIL-4産生誘導シグナル伝達機構とTh2分化
小田朗永、瀧伸介
臨床免疫・アレルギー科, 54, 546-553, 2010年 - 好塩基球からのIL-4産生誘導機序
肥田重明、瀧 伸介
炎症と免疫, 18, 9-13, 2010年 - Th2分化と好塩基球
肥田重明、瀧 伸介
実験医学, 28, 1879-1884, 2010年 - STAT6 signalling is important in CD8(+) T-cell activation and defence against Toxoplasma gondii infection in the brain
Jin, Donghao; Takamoto, Masaya; Hu, Tao; Taki, Shinsuke; Sugane, Kazuo;
IMMUNOLOGY, 127(2), 187-195, 2009年06月 - Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils
Hida, Shigeaki; Yamasaki, Sho; Sakamoto, Yuzuru; Takamoto, Masaya; Obata, Kazushige; Takai, Toshiyuki; Karasuyama, Hajime; Sugane, Kazuo; Saito, Takashi; Taki, Shinsuke;
NATURE IMMUNOLOGY, 10(2), 214-222, 2009年02月 - IL-3レセプターシグナルによる好塩基球のサイトカイン産生制御の解明
肥田重明、瀧 伸介
医学のあゆみ, 230(4), 303, 2009年 - 好塩基球のIL-4産生における細胞内シグナル伝達
瀧 伸介
実験医学, 27, 3271-3278, 2009年 - Contribution of Th17 Cells, a New Subset of CD4(+) T Cells, to Angiogenic Response to Hindlimb Ischemia
Hata, Takeki; Takahashi, Masafumi; Kawaguchi, Masanori; Kashima, Yu-ichiro; Izawa, Atsushi; Hida, Shigeaki; Iwakura, Yo-ichiro; Taki, Shinsuke; Ikeda, U-ichi;
Circulation, 120(18), S1052-S1052, 2009年 - Distinct response in maintenance of human naive and memory B cells via IL-21 receptor and TCL1/Akt pathways
Nagumo, Haruo; Abe, Jun; Kano, Hirotsugu; Taki, Shinsuke; Yamazaki, Kazuko; Yamazaki, Takashi; Kobayashi, Norimoto; Koike, Kenichi; Sugane, Kazuo; Saito, Hirohisa; Agematsu, Kazunaga;
CELLULAR IMMUNOLOGY, 256(1-2), 56-63, 2009年 - Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling
Mizutani, Tatsuaki; Tsuji, Kohichiro; Ebihara, Yasuhiro; Taki, Shinsuke; Ohba, Yusuke; Taniguchi, Tadatsugu; Honda, Kenya;
EXPERIMENTAL HEMATOLOGY, 36(3), 255-264, 2008年 - IL-15 inhibits pre-B cell proliferation by selectively expanding Mac-1(+)B220(+) NK cells
Nakajima, S; Hida, S; Taki, S
Biochemical and biophysical research communications, 369(4), 1139-1143, 2008年 - Genetic control directed toward spontaneous IFN-alpha/IFN-beta responses and downstream IFN-gamma expression influences the pathogenesis of a murine psoriasis-like skin disease
Arakura, Fuyuko; Hida, Shigeaki; Ichikawa, Eri; Yajima, Chihiro; Nakajima, Shinsuke; Saida, Toshiaki; Taki, Shinsuke;
JOURNAL OF IMMUNOLOGY, 179(5), 3249-3257, 2007年 - IFN regulatory factor-2 deficiencyrevealed a novel checkpoint critical for the generation of peripheral NK cells
Taki S, Nakajima S, Ichikawa E, Saito T, Hida S
J Immunol, 174(10), 6005-6012, 2005年 - Negative control of basophil expansion by IRF-2 critical for the regulation of Th1/Th2 balance
Hida S, Tadachi M, Saito T, Taki S
BLOOD, 106(6), 2011-2017, 2005年 - Inhibitory NK receptor Ly49Q is expressed on subsets of dendritic cells in a cellular maturation- and cytokine stimulation-dependent manner
Toyama-Sorimachi, N; Omatsu, Y; Onoda, A; Tsujimura, Y; Iyoda, T; Kikuchi-Maki, A; Sorimachi, H; Dohi, T; Taki, S; Inaba, K; Karasuyama, H
J Immunol, 174(8), 4621-4629, 2005年 - IRFファミリー転写因子による免疫系の制御
瀧 伸介
信州医学雑誌, 52(3), 163-170, 2004年06月 - Overexpression of human acyl CoA thioesterase upregulates peroxisome biogenesis
Ishizuka M, Toyama Y, Watanabe H, Fujiki Y, Takeuchi A, Yamasaki S, Yuasa S, Miyazaki M, Nakajima N, Taki S, Saito T
Exp Cell Res, 297, 127-141, 2004年 - Defective development of splenic and epidermal CD4(+) dendritic cells in mice deficient for IFN regulatory factor-2
Ichikawa E, Hida S, Omatsu Y, Shimoyama S, Takahara K, Miyagawa S, Inaba K, Taki S
Proc Natl Acad Sci USA, 101(11), 3909-3914, 2004年 - Prostaglandin D-2 reinforces Th2 type inflammatory responses of airways to low-dose antigen through bronchial expression of macrophage-derived chemokine
Honda, K; Arima, M; Cheng, G; Taki, S; Hirata, H; Eda, F; Fukushima, F; Yamaguchi, B; Hatano, M; Tokuhisa, T; Fukuda, T
J Exp Med, 198(4), 533-543, 2003年 - Role for Bcl-6in generation and maintenance of memory CD8+ T cells
Ichii H, Sakamoto A, Hatano M, Okada S, Toyama H, Taki S, Arima M, Kuroda Y, Tokuhisa T
Nat Immunol, 3, 558-563, 2002年 - Predominant role of T cell receptor (TCR)-alpha chain in forming preimmune TCR repertoire revealed by clonal TCR reconstitution system
Yokosuka T, Takase K, Suzuki M, Nakagawa Y, Taki S, Takahashi H, Fujisawa T, Arase H, Saito T
J Exp Med, 195, 991-1001, 2002年 - C1q regulatory region polymorphism down-regulating murine C1q protein levels with linkage to lupus nephritis
Miura-Shimura Y, Nakamura K, Ohtsuji M, Tomita H, JiangY, Abe M, Zhang D, Hamano Y, Tsuda H, Hashimoto H, Nishimura H, Taki S, Shirai T, Hirose S
J Immunol, 169(3), 1334-1339, 2002年 - Type I interferons and autoimmunity: lessons from the clinic and from IRF-2-deficient mice
Taki S
Cytokine Growth Factor Rev, 13(4-5), 379-391, 2002年 - CD8+ T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-a/b signaling.
Hida, S., Ogasawara, K., Sato, K., Takayanagi, H., Yokochi, T., Sato, T., Hirose, S.,Shirai, T., Taki, S., Taniguchi, T.
Immunity, 13, 643-655, 2000年 - Requirement for IRF-1 in the microenvironment supporting development of natural killer cells.
Ogasawara, K., Hida, S., Azimi, N., Tagaya, Y., Sato, T., Yokochi-Fukuda, T.,Waldmann, T.A., Taniguchi, T., Taki, S.
Nature, 391, 700-703, 1998年 - Functional dissection of the cytoplasmic subregions of the IL-2 receptor bc chain in primary lymphocyte population.
Fujii, H., Ogasawara, K., Otsuka, H., Suzuki, M., Yamamura, K.-I., Yokochi, T., Miyazaki, T., Suzuki, H., Mak, T.W., Taki, S., Taniguchi, T.
EMBO J., 17, 6551-6557, 1998年 - B cell development under the condition of allelic inclusion.
Sonoda, E., Pewzner-Jung, Y., Schwers, S., Taki, S., Jung, S., Eilat, D., Rajewsky, K.
Immunity, 6, 225-233, 1997年 - Multi-stage regulation of Th1-type immune responses by the transcriptionfactor IRF-1
Taki, S., Sato, T., Ogasawara, K., Fukuda, T., Sato, M., Hida, H., Suzuki, G., Mitsuyama, M., Shin, E.-H., Kojima, K., Taniguchi, T., Asano, Y.
Immunity, 6, 673-679, 1997年 - The Iga/Igb heterodimer on m-negative proB cells is component for transducing signals to induce early B cell differentiation
Nagata, K., Nakamura, T., Kitamura, F., Kuramochi, S., Taki, S., Campbell, K.S. and Karasuyama, H.
Immunity, 7, 559-570, 1997年 - Rearrangement of upstream DH and VH region genes into a rearranged immunoglobulin variable region gene inserted into the immunoglobulin heavychain locus.
Taki, S., Schwenk, F., Rajewsky, K.
Eur. J. Immunol., 25, 1888-1896, 1995年 - An IRF-1 dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes.
Tamura, T., Ishihara, M., Lamphier, M.S., Tanaka, N., Oishi, I., Aizawa, S., T.,Mak, T.W., Taki, S., Taniguchi, T.
Nature, 376, 596-599, 1995年 - Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus.
Taki, S., Meiering, M., Rajewsky, K.
science, 262, 1268-1271, 1993年 - Somatically mutated IgG anti-DNA antibody clonally related to germ-line encoded IgM anti-DNA antibody
Taki S, Hirose S, Kinoshita K, Nishimura H, Shimamura T, Hamuro J, Shirai T
Eur. J. Immunol., 22, 987-992, 1992年 - T cell-dependent antibody production by Ly-1 B cells
Taki, S., Shmitt, M., Tarlinton, D., Förster, I, Rajewsky, K
Ann. N.Y. Acad. Sci., 651, 328-335, 1992年 - Retroviral expression of the human IL-2 gene in a murine T cell line results in cell growth autonomy and tumorigenicity.
Yamada G, Kitamura Y, Sonoda H, Harada H, Taki S, Mulligan RC, Osawa H, Diamanstein T, Yokoyama S, Taniguchi T
EMBO J., 6, 2705-2709, 1987年 - Unique structure of murine interleukin-2 as deduced from cloned cDNAs
Kashima N, Nishi-Kataoka C, Fujita T, Taki S, Yamada G, Hamuro J, Taniguchi T
Nature, 313, 402-404, 1985年
担当経験のある科目_授業
