宮原 大貴 (ミヤハラ ヒロキ)   

先鋭領域融合研究群 バイオメディカル研究所 

助教(特定雇用) 

学位

  • 博士(医学), 信州大学

研究キーワード

    アミロイドーシス

研究分野

  • 分子生物学
  • バイオインフォマティクス

メールアドレス

    12mh207j★shinshu-u.ac.jp

経歴

  • 2018年
    信州大学医学部医学科 助教(特定雇用)

学歴

  • 2017年, 信州大学, 医学
  • 2012年, 金沢大学, 工学
  • 2010年, 金沢大学, 工学部

論文

  • Macrophages in the reticuloendothelial system inhibit early induction stages of mouse apolipoprotein A-II amyloidosis
    Miyahara H, Dai J, Li Y, Cui X, Takeuchi H, Hachiya N, Kametani F, Yazaki M, Mori M, Higuchi K
    Amyloid, 30(2), 225-238, 2022年
    筆頭著者, 責任著者
  • Exercise suppresses mouse systemic AApoAII amyloidosis through enhancement of the p38 MAPK signaling pathway
    Cui X, Sawashita J, Dai J, Liu C, Igarashi Y, Mori M, Miyahara H, Higuchi K
    Dis Model Mech, 15(3), dmm049327, 2022年
    責任著者
  • Cyba and Nox2 mutant rats show different incidences of eosinophilia in the genetic background- and sex-dependent manner
    Mori M, Dai J, Miyahara H, Li Y, Kang X, Yoshimi K, Mashimo T, Higuchi K, Mathumoto K
    Exp Anim, 72(2), 233-241, 2022年
  • Polygenic control of the wavy coat of the NCT mouse: involvement of an intracisternal A particle insertional mutation of the protease, serine 53 (Prss53) gene, and a modifier gene
    Mori M, Liu C, Yoshizawa T, Miyahara H, Dai J, Igarashi Y, Cui X, Li Y, Kang X, Higuchi K
    Mamm Genome, 33(3), 451-464, 2022年
  • Glavonoid-rich oil supplementation reduces stearoyl-coenzyme A desaturase 1 expression and improves systemic metabolism in diabetic, obese KK-A mice
    Yuichi Igarashi, Shiho Iida, Jian Dai, Jia Huo, Xiaoran Cui, Jinko Sawashita, Masayuki Mori, Hiroki Miyahara, Keiichi Higuchi
    Biomedicine & Pharmacotherapy, 2021年
  • Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARα signaling pathway
    Jian Dai, Ying Li, Fuyuki Kametani, Xiaoran Cui, Yuichi Igarashi, Jia Huo, Hiroki Miyahara, Masayuki Mori,Keiichi Higuchi
    Elife, 2020年
  • Suppression of Mouse AApoAII Amyloidosis Progression by Daily Supplementation with Oxidative Stress Inhibitors
    Dai J, Ding X, Miyahara H, Xu Z, Cui X, Igarashi Y, Sawashita J, Mori M, Higuchi K
    Oxid Med Cell Longev, Volume 2019, 1263274, 2019年
  • Comprehensive proteomic profiles of mouse AApoAII amyloid fibrils provide insights into the involvement of lipoproteins in the pathology of amyloidosis
    Miyahara H, Sawashita J, Ishikawa E, Yang M, Ding X, Liu Y, Hachiya N, Kametani F, Yazaki M, Mori M, Higuchi K
    J Proteomics, (172), 111-121, 2018年
  • Apolipoprotein A-II induces acute-phase response associated AA amyloidosis in mice through conformational changes of plasma lipoprotein structure
    Yang M, Liu Y, Dai J, Li L, Ding X, Xu Z, Mori M, Miyahara H, Sawashita J, Higuchi K
    Sci Rep, (8), 5620, 2018年
  • Amyloidosis-inducing activity of blood cells in mouse AApoAII amyloidosis
    Ding X, Liu Y, Yang M, Li L, Miyahara H, Dai J, Xu Z, Matsumoto, Mori M, Higuchi k, Sawashita J
    Exp Anim, 67((2)), 105-115, 2018年
  • Coenzyme Q10 Prevents Senescence and Dysfunction Caused by Oxidative Stress in Vascular Endothelial Cells
    Huo J, Xu Z, Hosoe K, Kubo H, Miyahara H, Dai J, Mori M, Sawashita J, Higuchi K
    Oxid Med Cell Longev, 3181759, 2018年
  • Caloric restriction reduces the systemic progression of mouse AApoAII amyloidosis
    Li L, Sawashita J, Ding X, Yang M, Xu Z, Miyahara H, Mori M, Higuchi K
    PLOS ONE, 12((2)), e0172402, 2017年
  • Apolipoprotein A-II accelerates reactive AA amyloidosis
    Yang M, Liu Y, Li L, Miyahara H, Ding X, Dai J, Sawashita J, Mori M, Higuchi K
    Amyloid, 24((sup1)), 147-148, 2017年
  • Distribution of transmissible amyloid proteins in the liver with apolipoprotein A-II amyloidosis
    Liu Y, Sawashita J, Wang Y, Li L, Miyahara H, Ding X, Yang M, Higuchi K
    shinshu med J, 64((4)), 183-194, 2016年
  • Extracellular deposition of mouse senile AApoAII amyloid fibrils induced different unfolded protein responses in the liver, kidney, and heart
    Luo H, Sawashita J, Tian G, Liu Y, Li L, Ding X, Xu Z, Yang M, Miyahara H, Mori M, Qian J, Wang Y, Higuchi K
    Lab Invest, 95((3)), 320-33, 2015年
  • Factors to preserve CpG-rich sequences in methylated CpG islands
    Miyahara H, Hirose O, Satou K, Yamada Y
    BMC GENOMICS, (16), 144, 2015年

講演・口頭発表等

  • A cellular model of amyloid degradation using macrophages cultured with mouse AApoAII amyloid fibrils
    Hiroki Miyahara, Xiaoran Cui, Yuichi Igarashi, Ying Li, Jian Dai, Masayuki Mori, Keiichi Higuchi
    The XVII International Symposium of Amyloidosis, 2020年
  • CURCUMIN PROMOTES PROGRESSION OF AApoAII AMYLOIDOSIS IN MICE BY ACTIVATING THE PPARα SIGNALING PATHWAY
    Dai Jian, Cui Xiaoran, Igarashi Yuichi, Li Ying, Miyahara Hiroki, Mori Masayuki, Higuchi Keiichi
    The XVII International Symposium of Amyloidosis, 2020年
  • Proteomic Profiles of Mouse AApoAII Amyloid Fibrils Provide Insights into the Involvement of Lipoproteins in the Pathology of Amyloidosis
    Miyahara H, Mori M, Higuchi K
    第18回日本蛋白科学会年会, 2018年
  • Comprehensive proteomic analysis of Mouse AApoAII amyloidosis
    Miyahara H, Mori M, Higuchi K
    Asian Pacific Prion Symposium 2018 (APPS2018), 2018年
  • Proteomic Analysis of Mouse AApoAII Amyloidosis
    Miyahara H
    The 10th Institute for Biomedical Sciences International Symposium, 2018年

所属学協会

  • 日本アミロイドーシス研究会
  • 老化促進モデルマウス学会
  • 国際アミロイドーシス学会

共同研究・競争的資金等の研究課題

  • アミロイドーシス発症機構の分子生物学的研究