小西 博昭 (コニシ ヒロアキ)   

学術研究院(農学系)

農学部 農学生命科学科 生命機能科学コース 

教授 

学位

  • 博士(医学), 神戸大学

研究分野

  • 機能生物化学, 細胞情報伝達

メールアドレス

    hkonishi★shinshu-u.ac.jp

学歴

  • 1988年, 名古屋大学, 農学部, 食品工業化学科

論文

  • GAREM1 is involved in controlling body mass in mice and humans
    Tasuku Nishino, Takaya Abe, Mari Kaneko, Masanao Yokohira, Keiko Yamakawa, Katsumi Imaida, Hiroaki Konishi
    Biochemical and biophysical research communications, 628:91-97, 91-97, 2022年, 査読有り
    最終著者, 責任著者電子ジャーナル
  • Effect of the glycine-rich domain in GAREM2 on its unique subcellular localization upon EGF stimulation
    Nishino, Tasuku; Oshika, Tsuyoshi; Kyan, Moriatsu; Konishi, Hiroaki;
    CELLULAR & MOLECULAR BIOLOGY LETTERS, 26(1), 2021年リポジトリ電子ジャーナル
  • Transglutaminase-mediated cross-linking of WDR54 regulates EGF receptor-signaling
    Maeda, Akane; Nishino, Tasuku; Matsunaga, Ryota; Yokoyama, Atsushi; Suga, Hiroshi; Yagi, Toshiki; Konishi, Hiroaki;
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1866(2), 285-295, 2019年02月WebofScience電子ジャーナル
  • Behavioral analysis in mice deficient for GAREM2 (Grb2-associated regulator of Erk/MAPK subtype2) that is a subtype of highly expressing in the brain
    Nishino, Tasuku; Tamada, Kota; Maeda, Akane; Abe, Takaya; Kiyonari, Hiroshi; Funahashi, Yasuhiro; Kaibuchi, Kozo; Takumi, Toru; Konishi, Hiroaki;
    MOLECULAR BRAIN, 12(1), 2019年WebofScience電子ジャーナル
  • GAREM1 regulates the PR interval on electrocardiograms
    Kim, Hye Ok; Lim, Ji Eun; Kim, Myung Jun; Kang, Ji-One; Kim, Sung-Moon; Nam, Jeong Min; Tak, Jihoon; Konishi, Hiroaki; Nishino, Tasuku; Koh, In Song; Jin, Young-Ho; Baik, Hyung Hwan; Kim, Jin-Bae; Kim, Mi Kyung; Choi, Bo Youl; Lee, Sang-Hak; Jang, Yangsoo; Shin, Jinho; Oh, Bermseok;
    JOURNAL OF HUMAN GENETICS, 63(3), 297-307, 2018年03月WebofScience電子ジャーナル
  • Role of N-myristoylation in stability and subcellular localization of the CLPABP protein
    Maeda, Akane; Uchida, Moe; Nishikawa, Sumire; Nishino, Tasuku; Konishi, Hiroaki;
    Biochemical and biophysical research communications, 495(1), 1249-1256, 2018年WebofScience電子ジャーナル
  • Antagonizing effect of CLPABP on the function of HuR as a regulator of ARE-containing leptin mRNA stability and the effect of its depletion on obesity in old male mouse
    Nishino, Tasuku; Matsunaga, Ryota; Jikihara, Hiroshi; Uchida, Moe; Maeda, Akane; Qi, Guangying; Abe, Takaya; Kiyonari, Hiroshi; Tashiro, Satoshi; Inagaki-Ohara, Kyoko; Shimamoto, Fumio; Konishi, Hiroaki;
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1861(11), 1816-1827, 2016年11月WebofScience電子ジャーナル
  • Versatile function of the circadian protein CIPC as a regulator of Erk activation
    Matsunaga, Ryota; Nishino, Tasuku; Yokoyama, Atsushi; Nakashima, Akio; Kikkawa, Ushio; Konishi, Hiroaki;
    Biochemical and biophysical research communications, 469(3), 377-383, 2016年WebofScience電子ジャーナル
  • Functional relationship between CABIT, SAM and 14-3-3 binding domains of GAREM1 that play a role in its subcellular localization
    Nishino, Tasuku; Matsunaga, Ryota; Konishi, Hiroaki;
    Biochemical and biophysical research communications, 464(2), 616-621, 2015年WebofScience電子ジャーナル
  • A Brain-specific Grb2-associated Regulator of Extracellular Signal-regulated Kinase (Erk)/Mitogen-activated Protein Kinase (MAPK) (GAREM) Subtype, GAREM2, Contributes to Neurite Outgrowth of Neuroblastoma Cells by Regulating Erk Signaling
    Taniguchi, Tomonori; Tanaka, Shigeru; Ishii, Ayumi; Watanabe, Miyuki; Fujitani, Noriko; Sugeo, Ayusa; Gotoh, Shuhei; Ohta, Takeshi; Hiyoshi, Mineyoshi; Matsuzaki, Hideki; Sakai, Norio; Konishi, Hiroaki;
    JOURNAL OF BIOLOGICAL CHEMISTRY, 288(41), 29934-29942, 2013年WebofScience電子ジャーナル
  • A Ca2+-dependent Mechanism of Neuronal Survival Mediated by the Microtubule-associated Protein p600
    Belzil, Camille; Neumayer, Gernot; Vassilev, Alex P.; Yap, Kyoko L.; Konishi, Hiroaki; Rivest, Serge; Sanada, Kamon; Ikura, Mitsuhiko; Nakatani, Yoshihiro; Minh Dang Nguyen;
    JOURNAL OF BIOLOGICAL CHEMISTRY, 288(34), 24452-24464, 2013年WebofScience電子ジャーナル
  • The Detergent-Soluble Cytoplasmic Pool of Survivin Suppresses Anoikis and Its Expression Is Associated with Metastatic Disease of Human Colon Cancer
    Hori, Masato; Miki, Tomoharu; Okamoto, Mayumi; Yazama, Futoshi; Konishi, Hiroaki; Kaneko, Hiroshi; Shimamoto, Fumio; Ota, Takahide; Temme, Achim; Tatsuka, Masaaki;
    PLOS ONE, 8(2), 2013年WebofScience電子ジャーナル
  • Inhibitory effect of SPE-39 due to tyrosine phosphorylation and ubiquitination on the function of Vps33B in the EGF-stimulated cells
    Ishii, Ayumi; Kamimori, Kanae; Hiyoshi, Mineyoshi; Kido, Hiroshi; Ohta, Takeshi; Konishi, Hiroaki;
    FEBS Letters, 586(16), 2245-2250, 2012年WebofScience電子ジャーナル
  • Role of a tyrosine phosphorylation of SMG-9 in binding of SMG-9 to IQGAP and the NMD complex
    Takeda, Saori; Fujimoto, Ai; Yamauchi, Emiko; Hiyoshi, Mineyoshi; Kido, Hiroshi; Watanabe, Takashi; Kaibuchi, Kozo; Ohta, Takeshi; Konishi, Hiroaki;
    Biochemical and biophysical research communications, 410(1), 29-33, 2011年WebofScience電子ジャーナル
  • New Functional Proteins Identified by Proteomic Analysis in the Epidermal Growth Factor Receptor-mediated Signaling Pathway and Application for Practical Use
    Tashiro, Kyoko; Konishi, Hiroaki; Nabeshi, Hiromi; Yamauchi, Emiko; Taniguchi, Hisaaki;
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 130(4), 471-477, 2010年04月WebofScience
  • Distinct functions of human MVB12A and MVB12B in the ESCRT-I dependent on their posttranslational modifications
    Tsunematsu, Takumi; Yamauchi, Emiko; Shibata, Hideki; Maki, Masatoshi; Ohta, Takeshi; Konishi, Hiroaki;
    Biochemical and biophysical research communications, 399(2), 232-237, 2010年WebofScience電子ジャーナル
  • GAREM, a Novel Adaptor Protein for Growth Factor Receptor-bound Protein 2, Contributes to Cellular Transformation through the Activation of Extracellular Signal-regulated Kinase Signaling
    Tashiro, Kyoko; Tsunematsu, Takumi; Okubo, Hiroko; Ohta, Takeshi; Sano, Etsuko; Yamauchi, Emiko; Taniguchi, Hisaaki; Konishi, Hiroaki;
    JOURNAL OF BIOLOGICAL CHEMISTRY, 284(30), 20206-20214, 2009年WebofScience電子ジャーナル
  • D-Dopachrome tautomerase is a candidate for key proteins to protect the rat liver damaged by carbon tetrachloride
    Hiyoshi, Mineyoshi; Konishi, Hiroaki; Uemura, Hirokazu; Matsuzaki, Hideki; Tsukamoto, Hideo; Sugimoto, Ryusuke; Takeda, Hideo; Dakeshita, Satoru; Kitayama, Atsushi; Takami, Hidenobu; Sawachika, Fusakazu; Kido, Hiroshi; Arisawa, Kokichi;
    Toxicology, 255(1-2), 6-14, 2009年WebofScience電子ジャーナル
  • Novel tyrosine phosphorylated and cardiolipin-binding protein CLPABP functions as mitochondrial RNA granule
    Sano, Etsuko; Shono, Shigeichi; Tashiro, Kyoko; Konishi, Hiroaki; Yamauchi, Emiko; Taniguchi, Hisaaki;
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1783(6), 1036-1047, 2008年06月WebofScience電子ジャーナル
  • Contribution of peroxisome-specific isoform of lon protease in sorting PTS1 proteins to peroxisomes
    Omi, Sizue; Nakata, Rie; Okamura-Ikeda, Kazuko; Konishi, Hiroaki; Taniguchi, Hisaaki;
    JOURNAL OF BIOCHEMISTRY, 143(5), 649-660, 2008年05月WebofScience電子ジャーナル
  • Proteomic identification of the new functional proteins in the EGF receptor-mediated signaling pathway
    Konishi, Hiroaki;
    SEIKAGAKU, 79(8), 781-785, 2007年08月WebofScience
  • Muc4 is required for activation of ErbB2 in signet ring carcinoma cell lines
    Yokoyama, Atsushi; Shi, Bin-Hai; Kawai, Takayuki; Konishi, Hiroaki; Andoh, Ryota; Tachikawa, Hiroyuki; Ihara, Sayoko; Fukui, Yasuhisa;
    Biochemical and biophysical research communications, 355(1), 200-203, 2007年WebofScience電子ジャーナル
  • Mutation of the P13 ' kinase gene in a human colon carcinoma cell line, HCC2998
    Shi, Bin-Hi; Nashimoto, Takeshi; Andoh, Ryota; Konishi, Hiroaki; Kobayashi, Michimoto; Xu, Qingyun; Ihara, Sayoko; Fukui, Yasuhisa;
    DNA AND CELL BIOLOGY, 25(7), 399-405, 2006年07月WebofScience
  • CFBP is a novel tyrosine-phosphorylated protein that might function as a regulator of CIN85/CD2AP
    Konishi, Hiroaki; Tashiro, Kyoko; Murata, Yasunobu; Nabeshi, Hiromi; Yamauchi, Emiko; Taniguchi, Hisaaki;
    JOURNAL OF BIOLOGICAL CHEMISTRY, 281(39), 28919-28931, 2006年WebofScience電子ジャーナル
  • Suppression of the ligand-mediated down-regulation of epidermal growth factor receptor by Ymer, a novel tyrosine-phosphorylated and ubiquitinated protein
    Tashiro, Kyoko; Konishi, Hiroaki; Sano, Etsuko; Nabeshi, Hiromi; Yamauchi, Emiko; Taniguchi, Hisaaki;
    JOURNAL OF BIOLOGICAL CHEMISTRY, 281(34), 24612-24622, 2006年WebofScience電子ジャーナル

共同研究・競争的資金等の研究課題

  • EGF受容体下流アダプタータンパク質GAREM及びCLPABPの生理機能の解明
    科学研究費補助金, 基盤研究(C)
    2017年 - 2020年
  • 新規アダプタータンパク質GAREMの生理機能の解析
    科学研究費補助金, 基盤研究(C)
    2014年 - 2016年