Academic Assembly School of Medicine and Health Sciences Institute of Medicine

School of Medicine Department of Medicine (Diabetes, Endocrinology and Metabolism) 


Researcher Information


  • Doctor of Medicine

Field Of Study

  • 糖尿病学


  • 2012
    信州大学医学部内科学講座 糖尿病・内分泌代謝内科 教授
  • 2010
    信州大学大学院加齢病態制御学 教授
  • 1992 - 1996
    Cornell University

Educational Background

  • 1990, Shinshu University, Graduate School, Division of Medicine
  • 1986, Shinshu University, Faculty of Medicine
Research activity information


  • Retroperitoneal Schwannoma with Vertebral Body Compression Whose Diagnosis and Treatment Policy were Confirmed by CT-guided Needle Biopsy
    SHIMADA Yasuho, KUBOTA Satoshi, TAKAYAMA Shohei, SATO Yoshinori, KOBAYASHI Shota, KOMATSU Mitsuhisa
    The Shinshu Medical Journal, 70(3), 183-188, Jun. 2022リポジトリ電子ジャーナル
  • A Case of a Cystic Parathyroid Adenoma with Marked Hyperparathyroidism but Difficult Preoperative Diagnostic Imaging
    KUBOTA Satoshi, SHIMADA Yasuho, TAKAYAMA Shohei, OBA Takaaki, ITO Ken-ichi, KOMATSU Mitsuhisa
    The Shinshu Medical Journal, 70(3), 189-194, Jun. 2022リポジトリ電子ジャーナル
  • Exploring Hidden Atrial Fibrillation in Patients with Type 2 Diabetes Mellitus Admitted to Shinshu University Hospital
    Sekido Keiko, Sekido Takashi, Ohkubo Yohsuke, Shibata Yusuke, Kawata Iori, Yamaguchi Tomohiko, Sato Ai, Sato Yoshihiko, Komatsu Mitsuhisa
    The Shinshu Medical Journal, 69(2), 75-81, Apr. 2021リポジトリ電子ジャーナル
  • Aldosterone to Potassium Ratio after Adrenocorticotropin Stimulation in Unilateral Primary Aldosteronism Diagnosis
    Kitahara, Junichiro; Ohkubo, Yousuke; Kitajima, Kouhei; Nishio, Shin-ichi; Oiwa, Ako; Sato, Ai; Yamazaki, Masanori; Sakuma, Takahiro; Sano, Asami; Nishii, Yutaka; Komatsu, Mitsuhisa
    The Shinshu Medical Journal, 68(3), 159-168, 10 Jun. 2020リポジトリ電子ジャーナル
  • Loss of μ-crystallin causes PPARγ activation and obesity in high-fat diet-fed mice
    Ohkubo Y, Sekido T, Nishio SI, Sekido K, Kitahara J, Suzuki S, Komatsu K.
    Biochem Biophys Res Commun, 508(3), 912-920, 2019
  • Analysis for the Improvement of Inadequate Glycemic Control in Patients with Type 2 Diabetes Mellitus in Nagano, Japan
    Sato Ai, Sato Yoshihiko, Kobayashi Yuki, Yamazaki Masanori, Komatsu Mitsuhisa
    The Shinshu Medical Journal, 66(5), 319-324, 10 Oct. 2018リポジトリ電子ジャーナル
  • Long-term Effects of Ipragliflozin on Adipose Tissue in Japanese Patients with Obese Type 2 Diabetes
    Nishio Shin-ichi, Sekido Takashi, Ohkubo Yohsuke, Oiwa Ako, Komatsu Mitsuhisa
    The Shinshu Medical Journal, 66(1), 29-37, 10 Feb. 2018リポジトリ電子ジャーナル
  • Two Cases of Primary Biliary Cholangitis with Hepatocellular Carcinoma in a Non-cirrhotic Stage
    The Shinshu Medical Journal, 66(1), 39-49, Feb. 2018リポジトリ電子ジャーナル
  • Careful readings for a flash glucose monitoring system in nondiabetic Japanese subjects: individual differences and discrepancy in glucose concentrarion after glucose loading
    Sekido K, Sekido T, Kaneko A, Hosokawa M, Sato A, Sato Y, Yamazaki M, Komatsu M
    Endocr J., 64(8), 827-832, 2017
  • Lixisenatide improves glycemic outcomes of Japanese patients with type 2 diabetes: a meta-analysis.
    Seino H, Onishi Y, Naito Y, Komatsu M.
    Diabetol Metab Syndr., 8, 36, 2016
  • The Ratio of Plasma Aldosterone Concentration to Potassium in Adrenocorticotropin Stimulation Test is a Possible New Index for Diagnosis of Aldosterone-producing Adenoma in Patients with Primary Aldosteronism
    ISHII, Hiroaki; KOBAYASHI, Yuki; SHIBATA, Yusuke; MIYAKOSHI, Takahiro; MIYAKOSHI, Wakana; KITAHARA, Jun-ichiro; KATO, Kousuke; YOKOTA, Naokazu; KAWAI, Yuko; KOMATSU, Mitsuhisa
    The Shinshu Medical Journal, 63(3), 145-156, 10 Jun. 2015リポジトリ電子ジャーナル
  • Glucose-stimulated insulin secretion: A newer perspective.
    Komatsu M
    J Diabetes Invest, 4, 511-516, 2013
  • Humoral hypercalcemia associated with gastric carcinoma secreting parathyroid hormone: a case report and review of the literature.
    Nakajima K, Tamai M, Okaniwa S, Nakamura Y, Kobayashi M, Niwa T, Horigome N, Ito N, Suzuki S, Nishio S, Komatsu M
    Endocr J, 60, 557-562, 2013
  • A new experimental model of ATP-sensitive K+ channel-independent insulinotropic action of glucose: a permissive role of cAMP for triggering of insulin release from rat pancreatic β-cells.
    Takei M, Dezaki K, Ishii H, Nishio S, Sato Y, Suzuki S, Yada T, Komatsu M.
    Endocr J, 60, 599-607, 2013
  • Clinical features of a new disease concept, IgG4-related thyroiditis.
    Watanabe T, Maruyama M, Ito T, Fujinaga Y, Ozaki Y, Maruyama M, Kodama R, Muraki T, Hamano H, Arakura N, Kadoya M, Suzuki S, Komatsu M, Shimojo H, Notohara K, Uchida M, Kawa S.
    Scand J Rheumatol., 42, 325-330, 2013
  • Possible roles of the AP-1 site in the cytosolic T3 binding protein promoter and insights into its physiological significance.
    Suzuki S, Nishio SI, Ishii H, Sekido T, Takeshige K, Ohkubo Y, Hiwatashi D, Takeda T, Komatsu M
    Horm Metab Res, 45, 501-506, 2013
  • Case report: Beneficial effect of 11β-hydroxylase inhibitor in the management of an elderly patient with an androgen-producing inoperable adrenal tumor.
    Ozawa W, Sato K, Miyakoshi T, Nishio S, Yamazaki M, Suzuki S, Komatsu M
    Geriatr Gerontol Int, 13, 509-511, 2013
  • Gender-specific regulation of response to thyroid hormone in aging
    Suzuki S, Nishio S, Takeda T, Komatsu M
    Thyroid Res, 5, 1, 26 Jan. 2012, Refereed
  • Availability of self-recorded axillary temperature for assessmentof thermic effects of food: relationship between HDL-cholesterol level and postprandial thermoregulation in type 2 diabetic patients.
    Suzuki S, Nishio SI, Ishii H, Sato A, Takeda T, Komatsu M
    Exp Clin Endocrinol Diabetes, 120, 96-100, 09 Jan. 2012
  • A Case of Severe and Recurrent Painless Thyroiditis Requiring Thyroidectomy.
    Ishii H, Takei M, Sato Y, Ito T, Ito KI, Sakai Y, Wataru Y, Suzuki S, Komatsu M
    Med Princ Pract, 22, 408-410, 2012電子ジャーナル
  • Amiodarone-induced thyrotoxicosis with thyroid papillary cancer in multinodular goiter: case report
    Inaba H, Suzuki S, Takeda T, Kobayashi S, Akamizu T, Komatsu M
    Med Princ Pract, 21, 190-192, 17 Nov. 2011, Refereed
  • Glucose-incretin interaction revisited.
    Ishii H, Sato Y, Takei M, Nishio S, Komatsu M
    Endocrine journal, 58(7), 519-525, 23 Jan. 2011, RefereedWebofScienceリポジトリ電子ジャーナル
  • Transient polyuria related to central diabetes insipidus caused by lymphocytic infundibulo-neurohypophysitis in a patient treated for Graves'disease
    Yamazaki M, Sato A, Nishio S, Uehara T, Komatsu M
    Intern Med, 49, 1885-1890, 01 Sep. 2010, Refereed
  • Cold-induced sweating syndrome with neonatal features of Crisponi syndrome: longitudinal observation of a patient homozygous for a CRLF1 mutation
    Yamazaki M, Kosho T, Kawachi S, Mikoshiba M, Takahashi J, Sano R, Oka K, Yoshida K, Watanabe T, Kato H, Komatsu M, Kawamura R, Wakui K, Knappskog PM, Boman H, Fukushima Y
    Am J Med Genet A, 152A, 764-769, Mar. 2010, Refereed
  • Distinct Clinical Courses in Type 1 Diabetes Mellitus Induced by Peg-interferon-alpha Treatment for Chronic Hepatitis C
    Yamazaki, Masanori; Sato, Ai; Takeda, Teiji; Komatsu, Mitsuhisa
    INTERNAL MEDICINE, 49(5), 403-407, 2010WebofScienceリポジトリ電子ジャーナル
  • Enhancement of the incretin pathway in response to bariatric surgery is important for restoration of beta cell function
    Komatsu, M; Aizawa,T
    DIABETOLOGIA, 42(2), 374-375, 2009WebofScienceリポジトリ電子ジャーナル
  • Development, worsening, and improvement of diabetic microangiopathy in older people: Six-year prospective study of patients under intensive diabetes control
    Katakura, M; Naka, M; Kondo, T; Komatsu, M; Yamauchi, K; Hashizume, K; Aizawa, T
    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 55(4), 541-547, 2007WebofScience電子ジャーナル
  • Suppression of expression of muscle-associated proteins by PPARalpha in brown adipose tissue
    Tong Y, Hara A, Komatsu M, Tanaka N, Kamijo Y, Gonzalez FJ, Aoyama T
    Biochem Biophys Res Commun, 336, 76-83, 2005
  • Rab27a: a new face in beta cell metabolism-secretion coupling
    Aizawa T, Komatsu M
    J Clin Invest, 115, 227-230, 2005
  • Development, progression, and regression of microalbuminuria in Japanese patients with type 2 diabetes under tight glycemic and blood pressure control: the Kashiwa study
    Yamada T, Komatsu M, Komiya I, Miyahara Y, Shima Y, Matsuzaki M, Ishikawa Y, Mita R, Fujiwara M, Furusato N, Nishi K, Aizawa T
    Diabetes Care, 28, 2733-2738, 2005
  • Correlation between the Pituitary Size and Function in Patients with Asthenia
    Yamada T, Nojiri K, Sasazawa H, Tsukui T, Miyahara Y, Nakayama K, Komatsu M, Aizawa T, Komiya I
    Endocr J, 52, 441-444, 2005
  • 経口薬を併用でうまく使う
    青木雄次,片倉正文,駒津光久,近藤照貴,仲元司,山内恵史,相澤 徹
    プラクテイス, 22, 303-308, 2005
  • Primacy of beta-cell dysfunction in the development of hyperglycemia: a study in the Japanese general population
    Katakura M, Komatsu M, Sato Y, Hashizume K, Aizawa T
    Metabolism, 53, 949-953, 2004
  • 加齢に伴う耐糖能低下のメカニズム
    相澤 徹,駒津光久
    内分泌・糖尿病科, 19, 569-579, 2004
  • リンパ球性漏斗神経下垂体炎による中枢性尿崩症にステロイドが奏功した1例
    ホルモンと臨床 増刊号「内分泌 興味ある症例 第45集」, 52, 17-20, 2004
  • 糖尿病と蛋白のアシル化
    駒津光久,相澤 徹
    内分泌・糖尿病科, 18, 338-343, 2004
  • Nutrient modulation of palmitoylated 24-kDa protein in rat pancreatic islets
    S Yamada, M Komatsu, Y Sato, K Yamauchi, T Aizawa, I Kojima
    Endocrinology, 144, 5232-5241, 2003
  • Prospective analysis of mortality, morbidity, and risk factors in elderly diabetics Nagano study.
    M Katakura, M Naka, T Kondo, N Nishii, M Komatsu, Y Sato,K Yamauchi, K Hiramatsu, M Ikeda, T Aizawa, K Hashizume
    Diabetes Care, 26, 638-644, 2003
  • 血糖値1556 mg/dlでありながらケトアシドーシス、非ケトン性高浸透圧性昏睡を呈さなかった糖尿病の1例
    糖尿病, 46, 437-440, 2003
  • <<2型糖尿病では何が起こっているか>>膵β細胞ーインスリン初期分泌の低下とは
    内科, 9(1), 35-39, 2003
  • シンポジウムI 21世紀の糖尿病療養ー人間ドック、健診の果たす役割ー
    健康医学ー日本人間ドック学会誌ー, 17(4), 487-514, 2003
  • 重症の糖尿病性網膜症を有する患者の内科的管理の注意点
    糖尿病診療のコツと落とし穴. 河盛隆造編, 30, 2003
  • Time-dependent stimulation of insulin exocytosis by 3',5'-cyclic adenosine monophosphate in the rat islet beta-cell
    S Yamada, M Komatsu, Y Sato, K Yamauchi, I Kojima, T Aizawa, K Hashizume
    Endocrinology, 143, 4203-4209, 2002
  • Time-dependent potentiation of the beta-cell is aCa2+-independent phenomenon
    S Yamada, M Komatsu, T Aizawa, Y Sato, H Yajima, T Yada, S Hashiguchi, K Yamauchi, K Hashizume
    JOURNAL OF ENDOCRINOLOGY, 172, 345-354, 2002
  • The effects of cerulenin, an inhibitor of protein acylation, on the two phases of glucose-stimulated insulin secretion
    SG Straub, H Yajima, M Komatsu, T Aizawa, GWG Sharp
    DIABETES, 51, S91-S95, 2002
  • A problem with the diagnosis of diabetes mellitus based on fasting plasma glucose
    Y Sato, H Ohfusa, M Katakura, M Komatsu, S Yamada, K Yamauchi, K Ichikawa, T Aizawa, K Hashizume
    Diabetic Medicine, 19, 82-83, 2002
  • Diminution of early insulin response to glucose in subjects with normal but minimally elevated fasting plasma glucose. Evidence for early beta-cell dysfunction
    Y Sato, M Komatsu, M Katakura, H Ohfusa, S Yamada, K Yamauchi, K Hiramatsu, K Ichikawa, T Aizawa, K Hashizume
    Diabetic Medicine, 19, 566-571, 2002
  • Triggering ofinsulin release by a combination of cAMP signal and nutrients: an ATP sensitive K+ channel-independent phenomenon
    M Komatsu, Y Sato, S Yamada, K Yamauchi, K Hashizume, T Aizawa
    DIABETES, 51(Suppl 1), S29-S32, 2002
  • Importance of nonionic signals for glucose-induced biphasic insulin secretion
    T Aizawa, Y Sato, M Komatsu
    DIABETES, 51(Suppl 1), S96-S98, 2002
  • 高齢期における糖尿病多発の機序
    Diabetes Frontier, 13, 321-325, 2002
  • インスリン分泌におけるKATPチャネル非依存性経路の役割
    糖尿病ナビゲーター メディカルレビュー社, 36-37, 2002
  • 日本人のインスリン分泌の特徴ム欧米人との違いー
    Mebio別冊 軽症2型糖尿病の治療戦略, 56-62, 2002
  • Effects of nipradilol, a nitric oxide-releasing beta-adrenoceptor blocking agent, on phosphoenolpyruvate carboxykinase gene transcription in a rat hepatoma cell line
    K Yamauchi, K Nakajima, S Ikeo, Y Nishimura, M Komatsu, T Aizawa, K Hashizume
    Jpn J Pharmacol, 87, 83-85, 2001
  • Treatment of type 2 diabetes: the sooner, the better
    T Yamada, M Komatsu, Y Sato, I Komiya, K Yamauchi, T Aizawa, K Hashizume
    J Intern Med, 250, 255-257, 2001
  • Glutamate is not a major conveyer of ATP-sensitive K+ channel-independent glucose action in pancreatic islet beta cell
    S Yamada, M Komatsu, Y Sato, K Yamauchi, T Aizawa, K Hashizume
    Endocrine journal, 48, 391-395, 2001
  • Norepinephrine inhibits glucose-stimulated, Ca2+-independent insulin release independently from its action on adenylyl cyclase
    H Yajima, M Komatsu, Y Sato, S Yamada, K Yamauchi, GWG Sharp, T Aizawa, K Hashizume
    Endocrine journal, 48, 647-654, 2001
  • KATP channel-independent glucose action: an elusive pathway in stimulus-secretion coupling of pancreatic ァ-cell
    M Komatsu, Y Sato, T Aizawa, K Hashizume
    Endocrine journal, 48, 275-288, 2001
  • Size-related and size-unrelated functional heterogeneity among pancreatic islets
    T Aizawa, T Kaneko, K Yamauchi, H Yajima, T Nishizawa,T Yada, H Matsukawa, M Nagai, S Yamada, Y Sato, M Komatsu, N Itoh, H Hidaka, Y Kajimoto, K Hashizume
    Life Science, 69, 2627-2639, 2001
  • ATP感受性Kチャネルを介さないインスリン分泌機構
    岡芳知編、糖尿病学 診断と治療社, 50-63, 2001
  • インスリン分泌─最近の話題─
    臨床透析, 17, 15-22, 2001
  • 妊娠後期に肝機能障害に伴い尿崩症様症状を呈した1例
    日本産婦人科学会関東連合地方部会会報, 38, 47-53, 2001
  • ブドウ糖によるインスリン分泌刺激ーtriggeringとaugmentationを区別する視点からのoverview-
    医学のあゆみ, 192, 359-364, 2000
  • 膵β細胞とインスリンシグナリング
    Mebio 別冊 Multiple Risk Factorと高血圧, 128-134, 2000
  • ブドウ糖による膵β細胞からのインスリン分泌機構ーATP感受性K+チャネルの閉鎖を介さないインスリン分泌刺激機構の解明ー
    上原記念生命科学財団研究報告集, 14, 305-307, 2000
  • Cerulenin, an inhibitor of protein acylation, selectively attenuates nutrient stimulation of insulin release: A study in rat pancreatic islets
    H Yajima, M Komatsu, S Yamada, SG Straub, T Kaneko, Y Sato, K Yamauchi, K Hashizume, GWG Sharp, T Aizawa
    DIABETES, 49(5), 712-717, 2000WebofScience
  • Importance of hypercoagulability over hyperglycemia for vascular complication in type 2 diabetes
    T Yamada, A Sato, T Nishimori, T Mitsuhashi, A Terao, H Sagai, M Komatsu, T Aizawa, K Hashizume
    Diabet Res Clin Pract, 49(1), 23-31, 2000WebofScience
  • Rapidoscillation of insulin release by the rat pancreatic islets under stringent Ca2+-free conditions
    T Aizawa, T Kaneko, H Yajima, S Yamada, Y Sato, Y Kanda, S Kanda, M Noda, T Kadowaki, M Nagai, K Yamauchi, M Komatsu, K Hashizume
    JOURNAL OF ENDOCRINOLOGY, 166(3), 545-551, 2000WebofScience
  • Selective attenuation of metabolic branch of insulin receptor down-signaling byhigh glucose in a hepatoma cell line, HepG2 cells
    K Nakajima, K Yamauchi, S Shigematsu, S Ikeo, M Komatsu, T Aizawa, K Hashizume
    J Biol Chem, 275(27), 20880-20886, 2000WebofScience
  • 糖尿病病型分類の問題点
    糖尿病学1999.小坂樹徳編, 49-60, 1999
  • ブドウ糖によるインスリン分泌機構における脂質メッセンジャーの役割
    Peptide Hormones in Pancreas, 19, 60-64, 1999
  • インスリン分泌促進薬
    Diabetes Frontier, 10, 826-830, 1999
  • ブドウ糖によるCa2+非依存性インスリン分泌刺激
    内分泌、糖尿病科, 9, 510-520, 1999
  • Augmentation of Ca2+-Stimulated Insulin Release by Glucose and Long Chain Fatty Acids in Rat Pancreatic Islets: Free Fatty Acids Mimic ATP-Sensitive K+ Channel-Independent Insulinotropic Action of Glucose
    M Komatsu, H Yajima, S Yamada, T Kaneko, Y Sato, K Yamauchi, K Hashizume, T Aizawa
    DIABETES, 48(8), 1543-1549, 1999WebofScience
  • CAMP enhances insulin secretion by an action on the ATP-sensitive K+ channel-independent pathway of glucose signaling in rat pancreatic islets
    H Yajima, M Komatsu, T Shermerhorn, T Aizawa, T Kaneko, M Nagai, GWG Sharp, K Hashizume
    DIABETES, 48(5), 1006-1012, 1999WebofScience
  • Long-term prognosis of islet cell antibody-negative ketosis-onset diabetes with subsequent non-insulin dependency
    M Katakura, T Aizawa, M Naka, Y Funase, M Komatsu, K Yamauchi, K Yoshizawa, K Hashizume
    Diabetes Care, 22(9), 1584-1586, 1999WebofScience
  • Nutrient augmentation of Ca2+-dependent and Ca2+-independent pathways in stimulus-coupling to insulin secretion can be distinguished by their guanosine triphosphate requirements:studies on rat pancreatic islets
    M Komatsu, M Noda, GWG Sharp
    Endocrinology, 139, 1172-1183, 1998
  • ケトーシスで発症し膵島抗体陰性の糖尿病患者の長期予後
    糖尿病, 41(suppl), A115-A117, 1998
  • 高齢者における橋本病の特徴
    日本老年医学会雑誌, 35, 771-776, 1998
  • 耐糖能異常
    Mebio別冊 Multiple risk factor syndrome 2. インスリン抵抗性の位置づけ, 62-67, 1998
  • 膵B細胞のインスリン分泌機構におけるプロテインキナーゼAのdistal effect
    Peptide Hormones in Pancreas, 18, 106-111, 1998
  • 自然発症糖尿病モデル動物における高濃度ブドウ糖の膵b細胞priming作用
    Peptide Hormones in Pancreas, 18, 48-52, 1998
  • Glucose action'beyond ionic events'in the pancreatic beta cell
    T Aizawa, M Komatsu, N Asanuma, Y Sato, GWG Sharp
    Trends. Pharmacol. Sci, 19(12), 496-499, 1998WebofScience電子ジャーナル
  • Palmitate and myristate selectively mimic the effect ofglucose in augmenting insulin release in the absence of extracellular Ca2+
    M Komatsu, GWG Sharp
    DIABETES, 47(3), 352-357, 1998WebofScience電子ジャーナル
  • Risk factors determining mortality in older diabetics: a pilot study in Japanese patients
    T Aizawa, S Shigematsu, K Hiramatsu, M Komatsu, K Yamauchi, T Kaneko, K Hashizume
    J Am Geriatr Soc, 46(4), 538-540, 1998WebofScience電子ジャーナル
  • Functional heterogeneity of pancreatic islets.
    Aizawa, T; Kaneko, T; Komatsu, M; Yajima, H; Nagai, M; Yamauchi, K; Hashizume, K
    DIABETOLOGIA, 41, A149-A149, 1998WebofScience
  • Augmentation of insulin release by glucose in the absence of extracellular Ca2+: New insights into stimulus-secretion coupling
    M Komatsu, T Schermerhorn, M Noda, SG Straub, T Aizawa, GWG Sharp
    DIABETES, 46(12), 1928-1938, 1997WebofScience
  • An early insulin intervention accelerates pancreatic beta-cell dysfunction in young Goto-Kakizaki rats, a model of naturally occurring noninsulin-dependent diabetes
    N Suzuki, T Aizawa, N Asanuma, Y Sato, M Komatsu, H Hidaka, N Itoh, K Yamauchi, K Hashizume
    Endocrinology, 138(3), 1106-1110, 1997WebofScience
  • Two signaling pathways, from the upper glycolytic flux and from the mitochondria, converge to potentiate insulin release
    N Asanuma, T Aizawa, Y Sato, T Schermerhorn, M Komatsu, GWG Sharp, K Hashizume
    Endocrinology, 138(2), 751-755, 1997WebofScience
  • Goto-Kakizaki rat, a model of glucose priming rather than glucose toxicity?
    Suzuki, N; Aizawa, T; Asanuma, N; Komatsu, M; Hashizume, K
    DIABETOLOGIA, 40, 452-452, 1997WebofScience
  • Pituitary adenylate cyclase-activating peptide, carbachol and glucose stimulate insulin release in the absence of an increase in intracellular Ca2+
    M Komatsu, T Schermerhorn, SG Straub, GWG Sharp
    Mol Pharmacol, 50, 1047-1054, 1996
  • The betaHC9 pancreatic beta cell line preserves the characteristics of the progenitor mouse islets
    M Noda, M Komatsu, GWG Sharp
    DIABETES, 45, 1766-1773, 1996
  • Analysis of the pancreatic beta cell in the mouse with targeted disruption of the pancreatic beta cell-specific glucokinase gene
    T Aizawa, N Asanuma, Y Terauchi, N Suzuki, M Komatsu, N Itoh, T Nakabayashi, H Hidaka, H Ohnota, K Yamauchi, K Yasuda, Y Yazaki, T Kadowaki, K Hashizume
    Biochem Biophys Res Commun, 229(2), 460-465, 1996WebofScience
  • Sodium fluoride stimulates exocytosis at a late site of calcium interaction in stimulus-secretion coupling: studies with the RINm5F beta-cell line
    M Komatsu, AM McDermott, GWG Sharp
    Mol Pharmacol, 47, 496-508, 1995
  • Time course of action of pertussis toxin to block theinhibition of stimulated insulin release by norepinephrine
    M Komatsu, AM McDermott, SL Gillison, GWG Sharp
    Endocrinology, 136, 1857-1863, 1995
  • Mastoparan increases [Ca2+]i by inhibition of the ATP-sensitive potassium channel intwo insulin-secreting cell lines
    GT Eddlestone, M Komatsu, L Shen, GWG Sharp
    Mol Pharmacol, 47, 787-797, 1995
  • Glucose stimulation of insulin release in the absence of extracellular Ca2+ and in the absence of any increase in intracellular Ca2+ in rat pancreatic islets
    M Komatsu, T Schermerhorn, T Aizawa, GWG Sharp
    Proc Natl Acad Sci U S A, 92(23), 10728-10732, 1995WebofScience
  • Insulin secretion by the pancreatic beta cell of aged rats
    T Aizawa, M Komatsu, Y Sato, F Ishihara, N Suzuki, N Nishii, K Hashizume, T Yamada
    Pancreas, 9(4), 454-459, 1994WebofScience
  • ATP-sensitive K+ channel-independent glucose action in rat pancreatic beta-cell
    T Aizawa, Y Sato, F Ishihara, N Taguchi, M Komatsu, N Suzuki, K Hashizume, T Yamada
    Am J Physiol, 266(3), C622-C627, 1994WebofScience
  • Mastoparan stimulates exocytosis at a Ca2+-independent late site in stimulus secretion coupling. Studies with the RINm5F beta-cell line
    M Komatsu, AM McDermott, SL Gillison, GWG Sharp
    J Biol Chem, 268, 23297-23306, 1993
  • Role of dehydroepiandrosterone and dehydroepiandrosterone sulfate for the maintenance of axillary hair in women
    F Ishihara, M Komatsu, T Yamada, T Aizawa, K Ichikawa, N Takasu, I Komiya
    Horm Metab Res, 25(1), 34-36, 1993WebofScience
  • Possible link between a low prevalence of cardiovascular disease and mild dyslipidaemia: a study in Japanese patients with type 2 diabetes
    T Aizawa, M Kobayashi, Y Sato, M Tozuka, F Ishihara, N Okada, S Shigematsu, M Komatsu, K Hiramatsu, K Yamauchi, I Komiya, T Yamada, M Kanai, Z Honda
    Diabetic Medicine, 10(5), 431-437, 1993WebofScience
  • Ten-year follow up of Japanese overweight subjects with impaired glucose tolerance: Identification of a diabetes-prone subpopulation
    T Yamada, T Aizawa, Y Nagasawa, M Ishihara, M Komatsu, I Komiya, T Shinoda, N Takasu
    Int Med, 31, 887-884, 1992
  • ATP-sensitive K+channel-independent, insulinotropic action of glucose in the B-cells
    T Aizawa, Y Sato, M Komatsu, K Hashizume
    Endocrine Regulation, 26, 159-170, 1992
  • Dual functional role of membrane depolarization/Ca2+ influx in rat pancreatic B-cell
    Y Sato, T Aizawa, M Komatsu, N Okada, T Yamada
    DIABETES, 41(4), 438-443, 1992WebofScience
  • Differential effects of body weight, hyperinsulinemiaand oral glucose load on serum C-peptide/Insulin molar ratio
    N Okada, M Kobayashi, H Ohtsuka, S Shigematsu, Y Nagasawa, M Komatsu, T Aizawa, T Yamada
    Horm Metab Res, 24(9), 429-433, 1992WebofScience
  • Abnormal molecular weight profile of urinary protein in rats with streptozotocin-induced diabetes
    N Okada, T Aizawa, N Yokokawa, M Kobayashi, T Moriya, S Shigematsu, T Shirota, M Komatsu, T Shinoda, T Yamada, K Nakazawa, N Itoh, H Shigematsu
    Diabet Res Clin Pract, 18(1), 1-9, 1992WebofScience
  • Mastoparan-induced hormone release from rat pancreatic islets
    M Komatsu, T Aizawa, N Yokokawa, Y Sato, N Okada, N Takasu, T Yamada
    Endocrinology, 130(1), 221-228, 1992WebofScience
  • A case of autoimmune insulin antibody syndrome associated with polymyositis, empty sella and apparant high urinary output of immunoreactive insulin
    K Ichikawa, Y Nishii, K Hashizume, M Chino, T Nagasawa, S Suzuki, N Okada, M Kobayashi, Y Koizumi, M Arai, M Komatsu, T Aizawa, T Asawa, F Ishihara, T Yamada
    ENDOCRINOLOGIA JAPONICA, 39(3), 307-313, 1992WebofScience
    INTERNAL MEDICINE, 31(7), 877-884, 1992WebofScience
  • Unusual clinical presentation of malignant histiocytosis in a 70-year-old woman
    M Komatsu, M Katakura, T Aizawa, Y Yukimura, T Yamada, H Saito, S Furuta, N Ito, Y Onishi
    J Int Med, 230(1), 73-77, 1991WebofScience
  • Gradual delay in glucose-induced first phase insulin secretion by the pancreatic islets of 7 week-, 6 month-, and 1 year-old rats
    M Komatsu, N Yokokawa, Y Nagasawa, I Komiya, T Aizawa, N Takasu, T Yamada
    J Gerontol, 46(2), B59-B64, 1991WebofScience
  • Dipyridamole reduces urinary albumin excretion in diabetic patients with normo- or microalbuminuria
    T Aizawa, S Suzuki, T Asawa, M Komatsu, S Shigematsu, N Okada, M Katakura, K Hiramatsu, T Shinoda, K Hashizume, N Takasu, T Yamada, Y Masaoka, M Mimura, H Takahashi, K Shimizu, Z Honda
    Clin Nephrol, 33(3), 130-135, 1990WebofScience
  • Mastoparan, a wasp venom, stimulates insulin release by pancreatic islets through pertussis toxin sensitive GTP-binding protein
    N Yokokawa, M Komatsu, T Takeda, T Aizawa, T Yamada
    Biochem Biophys Res Commun, 1989
  • Intestinal pseudo-obstruction due to dialysis amyloidosis
    T Shinoda, M Komatsu, T Aizawa, T Shirota, T Yamada, T Ehara, E Mizukami
    Clin Nephrol, 32, 284-289, 1989
  • Pharmacological characterizationof the voltage-dependent calcium channel of pancreaic B-cell
    Endocrinology, 125, 2008-2014, 1989
  • Glucose raises cytosolic free calcium in the rat pancreatic islets
    M Komatsu, T Aizawa, N Takasu, T Yamada
    Horm Metab Res, 21, 405-409, 1989
  • ACTH deficiency and TSH hypersecretion in a patient with empty sella turcica
    M Komatsu, T Aizawa, T Shinoda, T Yamada, T Mochizuki
    Am J Med Sci, 296, 186-189, 1989
  • Hydrogen peroxide generation in whole rat pancreatic islet; synergistic regulation by cytoplasmic free calcium and protein kinase-C
    N Takasu,M Komatsu, T Aizawa, T Yamada
    Biochem Biophys Res Commun, 155, 1988
  • Antipituitary antibody in patients with the primary empty sella syndrome
    M Komatsu, T Kondo, K Yamauchi, N Yokokawa, K Ichikawa, M Ishihara, T Aizawa, T Yamada, Y Imai, K Tanaka, K Taniguchi, T Watanabe, Y Takahashi
    J Clin Endocrinol Metab, 67, 633-638, 1988
  • インスリン分泌の分子機構.G蛋白シグナルとインスリン分泌機構 ATP感受性K+ チャネルを介さないブドウ糖によるインスリン分泌刺激
    分子糖尿病学の進歩1998 金原出版, 4-10, 1988

Books and other publications

  • 月刊糖尿病 6 9
    柴田有亮、河合裕子、駒津光久, GPR40作動薬 糖尿病治療薬はどこまできたかー新規治療薬開発の現状—
    49-55 2014
  • 内分泌・糖尿病・代謝内科 39 2
    駒津光久, KATP非依存性ブドウ糖応答性シグナルは生理的に重要か?
    122-127 2014
  • 先端医学社
    駒津光久, SGLUT2阻害薬の基礎データをみる 編集加来浩平 2型糖尿病治療の新展開〜SGLUT2阻害薬登場による新たな可能性〜
    30-43 2014
    樋渡大、駒津光久, 独居高齢者の症例報告
    28-32 2014
  • 糖尿病診療マスター 12
    駒津光久, SU薬のポジショニング SU薬はもういらないのか 
    156-161 2014
  • 最新医学 69
    駒津光久、佐藤吉彦、相澤徹, ブドウ糖によるインシュリン分泌とインクレチンー生理的意義の理解に向けてー 特報 第50回2013年度ベルツ賞受賞論文
    128-151 2014
  • 別冊プラクティス
    竹重恵子、関戸貴志、駒津光久, 内分泌疾患(先端巨大症、クッシング症候群、原発性アルドステロン症) 
    85-92 2014
  • プラクティス 30
    駒津光久, 医師・医療スタッフをつなぐ スキルと知識の維持と向上を目指して
    530 2013
  • プラクティス 30
    駒津光久, 糖尿病における急性期管理—糖尿病患者の急性合併症への正しい対応—
    289 2013
  • 医学出版 5
    北原順一郎、河合裕子、駒津光久, 薬剤による食後高血糖治療:グリニド薬 月刊糖尿病 食後高血糖改善薬による糖尿病治療
    60-65 2013
    相澤徹、大西雄太郎、駒津光久、野田光彦, 地域医療の現場で考える糖尿病診療の均てん化
    105-108 2012
  • 救急・集中治療 24
    樋渡大、関戸貴志、駒津光久, 膵臓における高血糖の急性毒性
    534-538 2012
  • JOHNS 28
    鈴木悟、駒津光久, 全身疾患と耳鼻咽喉科 内分泌—内分泌疾患から生じた耳鼻咽喉科疾患—
    1403-1406 2012
  • 内分泌・糖尿病・代謝内科  35
    大久保洋輔、竹重恵子、駒津光久, 加齢に伴う耐糖能低下の機序.
    9-12 2012
  • Endocrine 40 3
    Suzuki S, Shigematsu S, Inaba H, Takei M, Takeda T, Komatsu M, Pituitary resistance to thyroid hormones: pathophysiology and therapeutic options
    366-371 29 Sep. 2011, Refereed
    駒津光久, 高齢者の血糖コントロール
    184-185 2011
  • 荒木栄一、綿田裕孝編 最新インスリン療法
    駒津光久, 2型糖尿病のインスリン治療 インスリン治療がしばしば難渋するケース 高齢者や認知症患者
    中山書店, 180-184 2011
  • 佐田政隆、下村伊一郎、野出孝一、綿田裕孝編 血管糖尿病2011
    駒津光久, グリニドとSU薬
    フジメディカル出版, 214-218 2011
  • Geriatric Medicine 49
    山崎雅則、駒津光久, 高齢者におけるGLP-1受容体作動薬の使い方
    879-882 2011
  • 内分泌・糖尿病・代謝内科 30
    駒津光久, Closed-loopとopen-loopによる血糖制御
    化学評論社, 591-595 2010
  • International Review of Diabetes 2
    石原寿光、Meier JJ、駒津光久、税所芳史, 2型糖尿病における膵β細胞量とインクレチンの役割
    9-23 2010
  • International Review of Diabetes 2
    駒津光久, 機能的膵β細胞量を標的としたあらたな糖尿病治療—GLP-1治療の展望—
    24-25 2010
  • 臨床と研究 86
    駒津光久、相澤徹, インスリン分泌促進薬、αGI
    31-35 2009
  • Geriatric Medicine 47
    駒津光久、相澤徹, 高齢者糖尿病の最新薬物療法 高齢者;グリニド(速効型インスリン分泌促進薬)
    821-825 2009
    駒津光久、絵本正憲、田村好史、西田健朗、小川裕、田尻祐司、松葉育郎、渥美義仁、野田光彦, 次世代型人工膵臓研究会作業部会:ベッドサイド型人工膵臓を用いたグルコースクランプ法の標準化
    557-562 2009
  • Islet Equality 2
    駒津光久, β細胞の評価〜in vitro膵灌流実験〜
    3-6 2009
  • 南江堂
    駒津光久, 糖尿病療養指導 生活指導と自己管理 「糖尿病 最新の治療 2010-2012」
    267-269 2009
  • Geriatric Medicine 47
    駒津光久、相澤徹, 高齢者糖尿病の最新薬物療法 高齢者;グリニド(速効型インスリン分泌促進薬)
    821-825 2009
  • 内科 101 1
    駒津光久、山内恵史、相澤徹, <<糖尿病マネージメントup-to-date>>経口糖尿病薬
    18-24 2008
  • 新時代の糖尿病学(1) 66
    駒津光久, ブドウ糖によるKATPチャンネル非依存性のインスリン分泌機構
    日本臨床, 182-186 2008
  • 新時代の糖尿病学(1) 66
    駒津光久、相澤徹, 病態におけるインスリン分泌 2型糖尿病
    日本臨床, 200-204 2008
  • 糖尿病のすべてがわかる本 改訂新版
    相澤徹、山内恵史、駒津光久, 糖尿病を3段階で治療する
    144-167 2008
  • 糖尿病臨床スキルアップ 外来・病棟診療ノート
    駒津光久, 高齢糖尿病患者における注意点 野田光彦編
    南光堂, 280-287 2007
  • 糖尿病学 基礎と臨床
    相澤徹、駒津光久、佐藤吉彦, インスリン分泌におけるKATPチャネル非依存性経路の役割
    78-82 2007
  • 糖尿病学 基礎と臨床
    駒津光久, アミノ酸, 脂肪酸とインスリン分泌
    101-104 2007
  • 糖尿病療養指導Q&A
    駒津光久、相澤徹, グリニド薬ってどんな薬ですか?
    中外医学社, 158-160 2007
  • 信州医誌 55
    駒津光久, <治療の最前線>インスリンアナログの新たな時代
    23-24 2007
    駒津光久、相澤徹, 糖尿病〜血糖降下のための薬物療法、その選択〜
    10-12 2007
  • 日本医事新報 4340
    駒津光久、門伝剛、近藤照貴、勝盛弘三、鈴木克典, アナログインスリンを使いこなす
    C1-C6 2007
  • 内分泌・糖尿病科 25
    駒津光久, ブドウ糖刺激によるインスリン開口放出の生理学
    206-212 2007
  • medicina 43
    駒津光久, 高齢者糖尿病患者における注意点.糖尿病の臨床—基礎知識を実践にいかす
    82-84 2006
  • 糖尿病ケア 3
    駒津光久、相澤徹, 高齢患者さんにおける低血糖の予防と対応
    58-63 2006
  • 内分泌・糖尿病科 23
    駒津光久, 加齢とインスリン
    334-339 2006
  • Pancreatic ss-cell, a unique fuel senser. Dakshinamurti K, Zempleni J eda: Nutients and Cell Signaling
    Dekker/CRC Press, New York,, 533-564 2005
  • 膵島,春日雅人編:生活習慣病がわかる.わかる実験医学シリーズ
    相澤 徹,駒津光久, 糖尿病の病態と分子メカニズム(i)膵島
    羊土社,東京, 34-44 2005
  • 日本臨床 64
    駒津光久、橋爪潔志, 経口血糖降下薬療法における留意点.特集:高齢者糖尿病
    93-98 2005
  • 編:糖尿病カレントライブラリー2 インスリン分泌
    佐藤吉彦,駒津光久,矢島博樹,相澤 徹, KATPチャネル非依存性経路とその意義
    文光堂,東京, 19-22 2004
  • 糖尿病を3段階で治療する
    相澤徹、山内恵史、駒津光久, Joint work
    糖尿病のすべてがわかる本.矢沢サイエンスオフィス編 学研, 140-163 2003
  • 糖尿病
    相澤徹、駒津光久、山内恵史, Joint work
    臨床薬物治療学 アークメデイア, 601-606 2000
  • 耐糖能異常
    相澤徹、駒津光久、山内恵史、橋爪潔志, Joint work
    Mebio別冊 Multiple risk factor syndrome 2. インスリン抵抗性の位置づけ, 62-67 1998
  • 糖尿病 40
    駒津光久、橋爪潔志, インスリン分泌「非KATP経路」
    655-658 1997
  • 内分泌・糖尿科 5
    相澤徹、駒津光久、山内恵史、橋爪潔志, Glucose ToxicityとLipotoxicity.
    44-52 1997
  • Peptide Hormones in Pancreas 17
    駒津光久、相澤徹、G.W.G.Sharp、橋爪潔志, HIT細胞におけるブドウ糖によるCa2+非依存性のインスリン分泌増強作用
    32-36 1997
  • Progress in Medicine 17
    相澤徹、駒津光久、山内恵史、橋爪潔志, 糖尿病の成因の究明「インスリン分泌機序と糖尿病」
    1267-1272 1997
  • 専門医のための糖尿病学レビュー'97
    駒津光久、相澤徹、橋爪潔志, インスリンの生合成・分泌のメカニズム:ATP依存性K+ チャネル以外を介するインスリン分泌制御.河盛隆造、春日雅人編
    総合医学社、東京, 22-29 1997
  • Peptide Hormones in Pancreas 16
    麻沼奈穂子、駒津光久、G.W.G.Sharp、相澤徹、佐藤吉彦、石原藤樹、橋爪潔志, 膵β細胞におけるブドウ糖によるインスリン分泌刺激作用の多様性
    13-16 1996
  • Mebio 13 10
    相澤徹、麻沼奈穂子、佐藤吉彦、駒津光久、橋爪潔志, 膵β細胞における「K+ATPチャネル/カルシウムドグマ」の崩壊
    118-124 1996
  • Diabetes Journal 24
    相澤徹、駒津光久、橋爪潔志, インスリン分泌の分子機構
    133-140 1996
  • ATP-sensitive K+ channel-independent, glucose-induced signalling in the pancreatic B-cell. In Insulin secretion and pancreatic B-cell research
    T Aizawa, Y Sato, M Komatsu, F Ishihara, N Taguchi, K Hashizume, Joint work
    Flatt PR, Lenzen S, Eds. London, Portland Press Ltd., 167-172 1994
  • 信州医学雑誌 42
    相澤徹、佐藤吉彦、田口奈穂子、石原藤樹、駒津光久、橋爪潔志, ブドウ糖による膵B細胞刺激
    281-288 1994
  • Peptide Hormones in Pancreas 13
    石原藤樹、相澤徹、佐藤吉彦、田口奈穂子、駒津光久、橋爪潔志, ATP感受性K+チャネル非依存性のブドウ糖によるインスリン分泌刺激.−ブドウ糖代謝との乖離−
    204-207 1993
  • Existance of ATP-sensitive K+ channel-independent pathways in glucose-induced insulin release by the pancreatic B-cell.
    Y Sato, M Komatsu, N Okada, T Aizawa, T Yamada, Joint work
    In Prevention and Treatment of NIDDM Goto Y, Lee TH, Kaneko T, Shigeta Y, Eds. London, Smith-Gordon, 55-59 1992
  • Prediction of development of diabetes among overweight adults with normal or impaired glucose tolerance: a ten-year follow-up study
    Y Nagasawa, T Yamada, M Ishihara, M Komatsu, I Komiya, T Shinoda, T Aizawa, Joint work
    In Prevention and Treatment of NIDDM Goto Y, Lee TH, Kanako T, Shigeta Y, Eds. London, Smith-Gordon, 213-216 1992
  • Diabetes Frontier 3
    相澤徹、駒津光久、浅輪孝幸、長澤慶尚、山田隆司, 糖代謝の測定法:-グルコ-スクランプ法-
    373-380 1992
  • 糖尿病記録号1992
    相澤徹、駒津光久、佐藤吉彦, ATP-sensitive K+ channel非依存性のグルコ-スによるシグナリング.七里元亮編、第35回日本糖尿病学会年次学術集会記録
    医学図書出版, 93-98 1992
  • Peptide Hormones in Pancreas 12
    佐藤吉彦、駒津光久、相澤徹、岡田尚美、山田隆司, ATP感受性Kチャンネル非依存性のブドウ糖によるインスリン分泌刺激のメカニズム
    23-27 1992
  • Peptide Hormones in Pancreas 12
    駒津光久、相澤徹、佐藤吉彦、岡田尚美、西井中子、高須信行、山田隆司, マストパランによるインスリン放出刺激機構の解明
    17-22 1992
  • 日本臨床代謝学会記録 26
    高須信行、小宮一郎、浅輪孝幸、長沢慶尚、駒津光久、相澤徹, 膵ラ氏島H2O2産性とDNA損傷−Ca2+とPKCの相乗効果−糖尿病発症初期シグナル
    72-73 1989
  • インスリン分泌の分子機構.G蛋白シグナルとインスリン分泌機構 ATP感受性K+ チャネルを介さないブドウ糖によるインスリン分泌刺激
    駒津光久、相澤徹、橋爪潔志, Joint work
    分子糖尿病学の進歩1998 金原出版, 4-10 1988
  • 現代医療 20
    山田隆司、山内恵史、石原雅樹、駒津光久, 床下部-下垂体視ホルモン系
    1653-1658 1988
  • 内科 62
    石原雅樹、横川中子、駒津光久、山田隆司, 糖尿病患者の手術時における人工膵を用いた血糖管理について
    337-344 1988

Research Themes

  • 糖尿病の発症機構