梅澤 公二 (ウメザワ コウジ)
学術研究院（農学系）
バイオメディカル研究所
助教
研究者情報
研究キーワード
- 理論生物学・バイオインフォマティクス
経歴
研究活動情報
論文
- Correlation between tight binding of inhibitors and their target selectivity toward the non-native state in the DYRK family of kinases
Yamada, Natsumi; Suzuki, Sora; Fukahori, Nanae; Yamaoka, Yoshiyuki; Komiyama, Yuta; Kimura, Ninako; Umezawa, Koji; Kii, Isao
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 133, 2026年04月, 査読有り
- Temperature vaulting: A method for screening of slow- and tight-binding inhibitors that selectively target kinases in their non-native state
Suzuki, Sora; Umezawa, Koji; Furuie, Gaku; Kikuchi, Masaki; Nakamura, Daichi G. M.; Fukahori, Nanae; Kimura, Ninako; Yamakawa, Masato; Niwa, Takashi; Umehara, Takashi; Hosoya, Takamitsu; Kii, Isao
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 295, 2025年10月, 査読有り - Bottom-up design of peptide shapes in water using oligomers of N-methyl-l/d-alanine
Morimoto, Jumpei; Yokomine, Marin; Shiratori, Yota; Ueda, Takumi; Nakamuro, Takayuki; Takaba, Kiyofumi; Maki-Yonekura, Saori; Umezawa, Koji; Miyanishi, Koichiro; Fukuda, Yasuhiro; Watanabe, Takumu; Suga, Mayuko; Inayoshi, Ayumi; Yoshida, Takuya; Mizukami, Wataru; Takeuchi, Koh; Yonekura, Koji; Nakamura, Eiichi; Sando, Shinsuke
CHEMICAL SCIENCE, 16(23), 10512-10522, 2025年01月, 査読有り - Osteogenic CpG Oligodeoxynucleotide, iSN40, Inhibits Osteoclastogenesis in a TLR9-Dependent Manner
Ikeda, Rena; Kimura, Chihaya; Nihashi, Yuma; Umezawa, Koji; Shimosato, Takeshi; Takaya, Tomohide
LIFE-BASEL, 14(12), 2024年12月, 査読有り - A high-resolution structural characterization and physicochemical study of how a peptoid binds to an oncoprotein MDM2
Yokomine, Marin; Morimoto, Jumpei; Fukuda, Yasuhiro; Ueda, Takumi; Takeuchi, Koh; Umezawa, Koji; Ago, Hideo; Matsuura, Hiroaki; Ueno, Go; Senoo, Akinobu; Nagatoishi, Satoru; Tsumoto, Kouhei; Sando, Shinsuke
CHEMICAL SCIENCE, 15(19), 2024年05月, 査読有り - Development of the 12-base short dimeric myogenetic oligodeoxynucleotide that induces myogenic differentiation.
Umezawa K, Ikeda R, Sakamoto T, Enomoto Y, Nihashi Y, Shinji S, Shimosato T, Kagami H, Takaya T.
BioTech, 13(2), 11, 2024年, 査読有り
- Myogenetic oligodeoxynucleotide induces myocardial differentiation of murine pluripotent stem cells.
Ishioka M, Nihashi Y, Sunagawa Y, Umezawa K, Shimosato T, Kagami H, Morimoto T, Takaya T.
Int J Mol Sci, 24(18), 14380, 2023年, 査読有り - Identification of a novel osteogenetic oligodeoxynucleotide (osteoDN) that promotes osteoblast differentiation in a TLR9-independent manner.
Nihashi Y, Miyoshi M, Umezawa K, Shimosato T, Takaya T.
Nanomaterials, 12(10), 1680, 2022年05月14日, 査読有り - Myogenetic oligodeoxynucleotide complexed with berberine promotes differentiation of chicken myoblasts.
Nihashi Y, Shinji S, Umezawa K, Shimosato T, Ono T, Kagami H, Takaya T
ANIMAL SCIENCE JOURNAL, 92(1), e13597, 2021年07月25日, 査読有り - Identification of the myogenetic oligodeoxynucleotides (myoDNs) that promote differentiation of skeletal muscle myoblasts by targeting nucleolin
Shinji S, Umezawa K, Nihashi Y, Nakamura S, Shimosato T, Takaya T.
Frontiers in Cell and Developmental Biology, 8, 616706, 2021年01月, 査読有り - Hyperstable De Novo Protein with a Dimeric Bisecting Topology
Kimura N., Mochizuki K., Umezawa K., Hecht MH., Arai R.
ACS Synthetic Biology, 9(2), 254-259, 2020年01月17日 - Berberine and palmatine inhibit the growth of human rhabdomyosarcoma cells.
Shinji, S; Nakamura, S; Nihashi, Y; Umezawa, K; Takaya, T
Biosci Biotechnol Biochem, 84(1), 63-75, 2020年, 査読有り
- Distinct cell proliferation, myogenic differentiation, and gene expression in skeletal muscle myoblasts of layer and broiler chickens
Nihashi Y, Umezawa K, Shinji S, Hamaguchi Y, Kobayashi H, Kono T, Ono T, Kagami H, Takaya T
SCIENTIFIC REPORTS, 9, 16527, 2019年11月11日, 査読有り - Synthesis of epigallocatechin trimer, (epigallocatechin)2-epicatechin, and (epigallocatechin)2-catechin via a Lewis acid mediated one-pot condensation and their antitumor activities in prostate cancer cells.
Ichikawa M, Yamamoto S, Ishihara C, Nonobe S, Hattori Y, Umezawa K, Fujii H, Makabe H
Tetrahedron, 74(27), 3534-3542, 2018年07月05日, 査読有り - Structural and dynamical characteristics of tropomyosin epitopes as the major allergens in shrimp.
Ozawa H, Umezawa K, Takano M, Ishizaki S, Watabe S, Ochiai Y
Biochemical and biophysical research communications, 498(1), 2018年03月25日, 査読有り - Epicatechin oligomers longer than trimers have anti-cancer activities, but not the catechin counterparts
Takanashi K, Suda M, Matsumoto K, Ishihara C, Toda K, Kawaguchi K, Senga S, Kobayashi N, Ichikawa M, Katoh M, Hattori Y, Kawahara S, Umezawa K, Fujii H, and Makabe H
SCIENTIFIC REPORTS, 7(1), 7791, 2017年08月10日, 査読有り - Over-Destabilization of Protein-Protein Interaction in Generalized Born Model and Utility of Energy Density Integration Cutoff
Mizuhara Y, Parkin D, Umezawa K, Ohnuki J, Takano M
JOURNAL OF PHYSICAL CHEMISTRY B, 121, 4669-4677, 2017年04月20日, 査読有り - 分子動力学シミュレーションで探る天然変性タンパク質の準安定複合体構造と結合解離調節機構
梅澤公二
信州大学農学部紀要, 53, 34-43, 2017年03月21日 - Intrinsic disorder accelerates dissociation rather than association
Koji Umezawa, Jun Ohnuki, Junichi Higo, Mitsunori Takano
Proteins: Structure, Function, and Bioinformatics, -(-), 2016年05月18日, 査読有り - Enhanced sampling simulations to construct free-energy landscape of protein–partner substrate interaction
Jinzen Ikebe, Koji Umezawa, Junichi Higo
Biophysical Reviews, 8(1), 45-62, 2016年01月11日, 査読有り - 全原子コンピュータシミュレーションで解き明かす,天然変性蛋白 質の分子認識機構
肥後順一, 梅澤公二
生物物理, 54(2), 096-099, 2014年04月, 査読有り - virtual-system coupled multicanonical molecular dynamics simulation: Principles and applications to free-energy landscape of protein–protein interaction with an all-atom model in explicit solvent
Junichi Higo, Koji Umezawa, Haruki Nakamura
The Journal of Chemical Physics, 138, 184106, 2013年05月10日, 査読有り - 表面近傍における水分子の集団的な動き(並進と配向)の解析
梅澤公二, 肥後順一
アンサンブル, 15(1), 28-32, 2013年01月, 査読有り - Conformational ensembles of an intrinsically disordered protein pKID with and without a KIX domain in explicit solvent investigated by all-atom multicanonical molecular dynamics
Koji Umezawa, Jinzen Ikebe, Mitsunori Takano, Haruki Nakamura, Junichi Higo
BIOMOLECULES, 2(1), 104-121, 2012年02月22日, 査読有り - Theory for trivial trajectory parallelization of multicanonical molecular dynamics and application to a polypeptide in water
Jinzen Ikebe, Koji Umezawa, Narutoshi Kamiya, Takanori Sugihara, Yasushige Yonezawa, Yu Takano, Haruki Nakamura, Junichi Higo
JOURNAL OF COMPUTATIONAL CHEMISTRY, 32(7), 1286-1297, 2010年12月15日, 査読有り - Solvent flow patterns fluctuating largely around a protein and correlation with solvent density fluctuations: A molecular dynamics study
Koji Umezawa, Ryota Morikawa, Haruki Nakamura, Junichi Higo
The Journal of Chemical Physics, 132, 155103, 2010年04月16日, 査読有り - Conformational requirement on peptides to exert laminin's activities and search for protein segments with laminin's activities
Koji Umezawa, Jinzen Ikebe, Motoyoshi Nomizu, Haruki Nakamura, Junichi Higo
Biopolymers, 92(2), 124-131, 2009年01月29日, 査読有り - Solvent Site-Dipole Field Accompanying Protein-Ligand Approach Process
Norikazu Takano, Koji Umezawa, et al.
Chem-Bio Informatics Journal, 8(1), 14-24, 2008年04月29日, 査読有り - Structure dependency of a 24-residue peptide humanin on solvent and preferential solvation by trifluoroethanol studied by multicanonical sampling
Ryosuke Yagisawa, Narutoshi Kamiya, Jinzen Ikebe, Koji Umezawa, Junichi Higo
Chemical Physics Letters, 455(4-6), 293-296, 2008年04月10日, 査読有り - Collective solvent flows around a protein investigated by molecular dynamics simulation
Koji Umezawa, Junichi Higo, Sakurako Shimotakahara, Heisaburo Shindo
The Journal of Chemical Physics, 127(4), 045101, 2007年07月26日, 査読有り - Cyclic Peptide Analysis of the Biologically Active Loop Region in the Laminin α3 Chain LG4 Module Demonstrates the Importance of Peptide Conformation on Biological Activity
Kozue Kato-Takagaki, Nobuharu Suzuki, Fumiharu Yokoyama, Shu Takaki, Koji Umezawa, Junichi Higo, Marumi Mochizuki, Yamato Kikkawa, Shinya Oishi, Atsushi Utani, Motoyoshi Nomizu
Biochemistry, 46(7), 1952-1960, 2007年01月30日, 査読有り
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