長瀬 尚志 (ナガセ ヒサシ)
学術研究院（医学系）
医学部 医学科 病理学
助教
研究者情報
研究活動情報
論文
- Endogenous IFN-gamma facilitates Pneumocystis infection and downregulates carbohydrate receptors in CD4+ T cell-depleted mice
Yi Wang; Hisashi Nagase; Yoh-ichi Tagawa; Shinsuke Taki; Masaya Takamoto; ( Y. Wang and H. Nagase equally contributed to this work.)
FEBS Letters, 598(13), 1633-1643, 2024年06月, 査読有り, 指定なし
筆頭著者 - State-of-the-Art Cancer Immunotherapies.
Hisashi Nagase; Takuma Kato; Takayuki Yoshimoto
International journal of molecular sciences, 25(5), 2024年02月, 査読有り, 指定なし
筆頭著者
- Genetic deficiencies of both IL-4 receptor alpha chain and IL-10 trigger early onset of severe colitis in mice.
Hisashi Nagase; Masaya Takamoto; Nancy Noben-Trauth
Cellular immunology, 393-394, 104779-104779, 2023年, 査読有り, 指定なし
筆頭著者, 責任著者 - Present and Future Therapies in Alzheimer's Disease
長瀬尚志 中山耕三
Immunoregulatory Aspects of Immunotherapy, 177-197, 2018年
筆頭著者, 責任著者 - Potential Therapeutic Targets and gamma-Secretase-Regulated APP Signaling in Alzheimer’s Disease
Hisashi Nagase; Kohzo Nakayama
Anals of Neurodegenerative Disorders, 2016年, 指定なし
筆頭著者 - The Intracellular Domain of Amyloid Precursor Protein is a Potential Therapeutic Target in Alzheimer's Disease.
Hisashi Nagase; Kohzo Nakayama
Current drug discovery technologies, 11(4), 243-58, 2014年, 指定なし
筆頭著者 - γ-Secretase-regulated signaling typified by Notch signaling in the immune system.
Hisashi Nagase; Kohzo Nakayama
Current stem cell research & therapy, 8(5), 341-56, 2013年09月, 指定なし
筆頭著者 - γ-Secretase-regulated signaling: Notch, APP and Alzheimer's disease.
Nakayama K, Nagase H, Koh CS, Ohkawara T.
Current Psychopharmacology, 1, 155-166, 2012年 - γ-Secretase-regulated mechanisms similar to notch signaling may play a role in signaling events, including APP signaling, which leads to Alzheimer's disease.
Kohzo Nakayama; Hisashi Nagase; Chang-Sung Koh; Takeshi Ohkawara
Cellular and molecular neurobiology, 31(6), 887-900, 2011年08月, 指定なし
筆頭著者 - γ-Secretase-regulated signaling pathways, such as notch signaling, mediate the differentiation of hematopoietic stem cells, development of the immune system, and peripheral immune responses.
Hisashi Nagase; Chang-Sung Koh; Kohzo Nakayama
Current stem cell research & therapy, 6(2), 131-41, 2011年06月, 指定なし
筆頭著者 - The amyloid precursor protein intracellular domain alters gene expression and induces neuron-specific apoptosis.
Takeshi Ohkawara; Hisashi Nagase; Chang-Sung Koh; Kohzo Nakayama
Gene, 475(1), 1-9, 2011年04月, 査読有り, 指定なし
筆頭著者 - Do similar mechanisms regulated by γ-secretase play a potential role in signaling events involving type 1 transmembrane proteins including Notch, Delta andAPP?
Nakayama K, Nagase H, Hiratochi M, Koh CS, Ohkawara T.
Research Advances in Nucleic Acids Research, 3, 55, 2009年 - Similar mechanisms regulated by gamma-secretase are involved in both directions of the bi-directional Notch-Delta signaling pathway as well as play a potential role in signaling events involving type 1 transmembrane proteins.
Kohzo Nakayama; Hisashi Nagase; Masahiro Hiratochi; Chang-Sung Koh; Takeshi Ohkawara
Current stem cell research & therapy, 3(4), 288-302, 2008年12月, 指定なし
筆頭著者 - The intracellular domain of amyloid precursor protein induces neuron-specific apoptosis.
Kohzo Nakayama; Takeshi Ohkawara; Masahiro Hiratochi; Chang-Sung Koh; Hisashi Nagase
Neuroscience letters, 444(2), 127-31, 2008年10月, 査読有り, 指定なし
最終著者 - Despite increased CD4+Foxp3+ cells within the infection site, BALB/c IL-4 receptor-deficient mice reveal CD4+Foxp3-negative T cells as a source of IL-10 in Leishmania major susceptibility.
Hisashi Nagase; Kathryn M Jones; Charles F Anderson; Nancy Noben-Trauth
Journal of immunology (Baltimore, Md. : 1950), 179(4), 2435-44, 2007年08月, 査読有り, 指定なし
筆頭著者 - The Delta intracellular domain mediates TGF-beta/Activin signaling through binding to Smads and has an important bi-directional function in the Notch-Delta signaling pathway.
Masahiro Hiratochi; Hisashi Nagase; Yu Kuramochi; Chang-Sung Koh; Takeshi Ohkawara; Kohzo Nakayama
Nucleic acids research, 35(3), 912-22, 2007年, 査読有り, 指定なし
筆頭著者 - The relative contribution of IL-4 receptor signaling and IL-10 to susceptibility to Leishmania major.
Nancy Noben-Trauth; Rosalia Lira; Hisashi Nagase; William E Paul; David L Sacks
Journal of immunology (Baltimore, Md. : 1950), 170(10), 5152-8, 2003年05月, 査読有り, 指定なし
筆頭著者 - Significant role of Fas ligand-binding but defective Fas receptor (CD95) in lymph node hyperplasia composed of abnormal double-negative T cells.
Akio Matsuzawa; Motomu Shimizu; Yasutaka Takeda; Hisashi Nagase; Kazutoshi Sayama; Mikio Kimura
Immunology, 106(4), 470-5, 2002年08月, 査読有り, 指定なし
筆頭著者 - Human bronchial epithelium expresses interleukin-9 receptors and releases neutrophil chemotactic factor.
Akihiro Tsukadaira; Yoshio Okubo; Sekiya Koyama; Etsuro Sato; Hisashi Nagase; Kazunaga Agematsu; Koh Nakazawa
Experimental lung research, 28(2), 123-39, 2002年03月, 査読有り, 指定なし
筆頭著者 - The different process of class switching and somatic hypermutation; a novel analysis by CD27(-) naive B cells.
Haruo Nagumo; Kazunaga Agematsu; Norimoto Kobayashi; Koji Shinozaki; Sho Hokibara; Hisashi Nagase; Masaya Takamoto; Kozo Yasui; Kazuo Sugane; Atsushi Komiyama
Blood, 99(2), 567-75, 2002年01月, 査読有り, 指定なし
筆頭著者 - Characterization of mouse mammary tumour virus-induced migration of lymphoid cells into lymph nodes.
A Matsuzawa; T Yasuda; S Sakamoto; H Nagase; H Nakano; T Yoshimoto
Scandinavian journal of immunology, 53(6), 553-62, 2001年06月, 指定なし
筆頭著者 - Mechanism of hypergammaglobulinemia by HIV infection: Circulating memory B-cell reduction with plasmacytosis
Hisashi Nagase; Kazunaga Agematsu; Kiyoshi Kitano; Masaya Takamoto; Yoshio Okubo; Atsushi Komiyama; Kazuo Sugane
Clinical Immunology, 100(2), 250-259, 2001年, 指定なし
筆頭著者 - Mechanism of hypergammaglobulinemia by HIV infection: Circulating memory B-cell reduction with plasmacytosis
Nagase, H; Agematsu, K; Kitano, K; Takamoto, M; Okubo, Y; Komiyama, A; Sugane, K
Clinical Immunology, 100(2), 250-259, 2001年
- A pivotal role of cell-bound but not soluble CD4 molecules in full development of lupus-like manifestations in MRL-Fas(lprcg)/Fas(lprcg) mice.
Y Zhang; T Yasuda; C R Wang; T Yoshimoto; H Nagase; M Takamoto; A Tsubura; M Kimura; A Matsuzawa
Clinical and experimental immunology, 122(1), 124-32, 2000年10月, 指定なし
筆頭著者 - Impaired delayed-type hypersensitivity response in mutant mice secreting soluble CD4 without expression of membrane-bound CD4.
C R Wang; A Hino; T Yoshimoto; H Nagase; T Kato; K Hirokawa; A Matsuzawa; H Nariuchi
Immunology, 100(3), 309-16, 2000年07月, 査読有り, 指定なし
筆頭著者 - Immunological characterization of C3H mice congenic for Fas(lprcg), C3h/HeJ-Fas(lprcg)/Fas(lprcg).
T Yasuda; Y Zhang; H Nagase; T Kaneko; K Sayama; H Hashimoto; A Matsuzawa
Laboratory animals, 34(1), 46-55, 2000年01月, 指定なし
筆頭著者 - Alleviation of renal disease and lymphadenopathy in MRL-Fasp(lrcg)/Fas(lprcg) (MR-lpr(cg)) mice neonatally infected with mouse mammary tumor virus encoding superantigen strongly reactive with TCR Vbeta8.2 element.
A Matsuzawa; T Yasuda; Y Zhang; H Nagase; T Yoshimoto; M Kimura; A Tsubura
Viral immunology, 13(3), 297-311, 2000年, 指定なし
筆頭著者 - Interleukin-12 expression in B cells by transformation with Epstein-Barr virus.
T Yoshimoto; H Nagase; T Yoneto; J i Inoue; H Nariuchi
Biochemical and biophysical research communications, 252(3), 556-60, 1998年11月, 査読有り, 指定なし
筆頭著者 - Novel mutant mice secreting soluble CD4 without expression of membrane-bound CD4.
H Nagase; C R Wang; T Yoshimoto; C Sugishita; T Shiroishi; A Matsuzawa; H Nariuchi
European journal of immunology, 28(2), 403-12, 1998年02月, 査読有り, 指定なし
筆頭著者 - Functional analysis of T cells from mutant mice deleted of transmembrane portion of CD4 (III)
Chrong-Reen Wang; Takayuki Yoshimoto; Hideo Nariuchi; Hisashi Nagase; Akio Matsuzawa
Japanese Journal of Clinical Immunology, 21, 343-352, 1998年, 指定なし
筆頭著者 - Induction of interleukin-12 p40 transcript by CD40 ligation via activation of nuclear factor-kappaB.
T Yoshimoto; H Nagase; T Ishida; J Inoue; H Nariuchi
European journal of immunology, 27(12), 3461-70, 1997年12月, 査読有り, 指定なし
筆頭著者 - Deletion of CD4+ T cells by mouse mammary tumor virus (FM) superantigen with broad specificity of T cell receptor beta-chain variable region.
T Yoshimoto; H Nagase; H Nakano; A Matsuzawa; H Nariuchi
Virology, 223(2), 387-91, 1996年09月, 査読有り, 指定なし
筆頭著者 - Early activation signal transduction pathways of Th1 and Th2 cell clones stimulated with anti-CD3. Roles of protein tyrosine kinases in the signal for IL-2 and IL-4 production.
T Tamura; H Nakano; H Nagase; T Morokata; O Igarashi; Y Oshimi; S Miyazaki; H Nariuchi
Journal of immunology (Baltimore, Md. : 1950), 155(10), 4692-701, 1995年11月, 査読有り, 指定なし
筆頭著者 - A V beta 8.2-specific superantigen from exogenous mouse mammary tumor virus carried by FM mice.
T Yoshimoto; H Nagase; H Nakano; A Matsuzawa; H Nariuchi
European journal of immunology, 24(7), 1612-9, 1994年07月, 査読有り, 指定なし
筆頭著者
書籍等出版物
- Present and Future Therapies for Alzheimer's Disease
Hisashi Nagase; Kohzo Nakayama, 共著, Immunoregulatory Aspects of Immunotherapy, Chapter 8
InTechOpen, 2018年 - Amyloid Precursor Protein: Its signaling aspect and Alzheimer's disease
Kohzo Nakayama; Hisashi Nagase; Chang-Sung Koh; Takeshi Ohkawara, 共著, Amyloids: Composition, Functions and Pathology, Chapter 2
Nova Science Publishers, Inc., 2012年 - Intech Publishers, Inc.
Nakayama K, Nagase H, Koh CS, Ohkawara T., γ-Secretase-regulated signaling mechanisms: Notch and amyloid precursor protein.
Intech Publishers, Inc., 2011年
