医学博士, 信州大学大学院医学系研究科

ライフサイエンス, 代謝、内分泌学 , 肥満・糖尿病・脂肪肝・脂肪肝炎

ライフサイエンス, 生理学 , 病態栄養学

ライフサイエンス, 消化器内科学 , 肝臓病学

ライフサイエンス, 消化器内科学 , 消化器病学

ライフサイエンス, 病態医化学 , 病態医化学

人文・社会, 高等教育学 , 国際医学研究

2014年
信州大学大学院医学系研究科代謝制御学講座　准教授

2009年 - 2012年
信州大学大学院医学系研究科代謝制御学講座　助教（留学に伴う休職）

2006年 - 2009年
信州大学大学院医学系研究科代謝制御学講座　助教

2005年 - 2006年
信州大学医学部消化器内科　医員

2003年 - 2005年
昭和伊南総合病院内科

2002年 - 2003年
信州大学医学部消化器内科　医員

1995年 - 1996年
信州大学医学部内科　研修医

2009年 - 2014年, 米国国立衛生研究所　癌研究施設　代謝研究部門　客員研究員

2002年, 信州大学大学院医学系研究科, 代謝制御学講座

1995年, 信州大学医学部

評議員, 日本肝臓学会

評議員, 日本消化器病学会

評議員、NSTコーディネーター, 日本病態栄養学会

2020年
第23回日本病態栄養学会年次学術集会　若手研究会長賞

2015年
米国国立衛生研究所, The Fellows Award for Research Excellence in NIH

2014年
米国国立衛生研究所, The Fellows Award for Research Excellence in NIH

2013年
米国国立衛生研究所, The Fellows Award for Research Excellence in NIH

2010年
第23回日本消化器病学会奨励賞

2009年
信州大学医学部松医会賞基礎分野

2008年
日本肝臓学会第7回Schering-Plough Award基礎分野優秀賞

2007年
ウイルス肝炎研究財団　研究助成

多機能性分子・硫酸化糖脂質の機能と制御
中嶌岳郎, 田中直樹
信州医学雑誌, 71(3), 137-147, 2023年06月

2-Step PLT16-AST44 method: Simplified liver fibrosis detection system in patients with non-alcoholic fatty liver disease
Fujimori, Naoyuki; Kimura, Takefumi; Tanaka, Naoki; Yamazaki, Tomoo; Okumura, Taiki; Kobayashi, Hiroyuki; Wakabayashi, Shun-Ichi; Yamashita, Yuki; Sugiura, Ayumi; Pham, Jonathan; Pydi, Sai P.; Sano, Kenji; Joshita, Satoru; Umemura, Takeji;
HEPATOLOGY RESEARCH, 52(4), 352-363, 2022年04月

Serum Sulfatide Levels as a Biomarker of Active Glomerular Lesion in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Single Center Pilot Study
Harada, Makoto; Nakajima, Takero; Yamada, Yosuke; Aomura, Daiki; Yamaguchi, Akinori; Sonoda, Kosuke; Tanaka, Naoki; Hashimoto, Koji; Kamijo, Yuji;
JOURNAL OF CLINICAL MEDICINE, 11(3), 762, 2022年02月

Mucosal defect size predicts the adequacy of resection of <= 10 mm nonpedunculated colorectal polyps using a new cold snare polypectomy technique
Kudo, Takahiro; Horiuchi, Akira; Kyodo, Reiko; Tokita, Kazuhide; Tanaka, Naoki; Horiuchi, Ichitaro; Sano, Kenji;
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 33, E484-E489, 2021年12月

Mechanisms of Steatosis-Derived Hepatocarcinogenesis: Lessons from HCV Core Gene Transgenic Mice
Diao, Pan; Jia, Fangping; Wang, Xiaojing; Hu, Xiao; Kimura, Takefumi; Nakajima, Takero; Aoyama, Toshifumi; Moriya, Kyoji; Koike, Kazuhiko; Tanaka, Naoki;
ENGINEERING, 7(12), 1797-1805, 2021年12月

Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell Studies
Jia, Fangping; Hu, Xiao; Kimura, Takefumi; Tanaka, Naoki;
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(19), 10303, 2021年10月

Pemafibrate Protects against Fatty Acid-Induced Nephropathy by Maintaining Renal Fatty Acid Metabolism
Aomura, Daiki; Harada, Makoto; Yamada, Yosuke; Nakajima, Takero; Hashimoto, Koji; Tanaka, Naoki; Kamijo, Yuji;
METABOLITES, 11(6), 372, 2021年06月

Linked colour imaging versus white-light colonoscopy for the detection of flat colorectal lesions: A randomized controlled trial
Kudo, Takahiro; Horiuchi, Akira; Kyodo, Reiko; Horiuchi, Ichitaro; Arai, Nobuyasu; Kajiyama, Masashi; Tanaka, Naoki;
COLORECTAL DISEASE, 23(6), 1414-1420, 2021年06月

Serum thrombospondin 2 is a novel predictor for the severity in the patients with NAFLD
Kimura, Takefumi; Tanaka, Naoki; Fujimori, Naoyuki; Yamazaki, Tomoo; Katsuyama, Takahito; Iwashita, Yuichi; Pham, Jonathan; Joshita, Satoru; Pydi, Sai P.; Umemura, Takeji;
LIVER INTERNATIONAL, 41(3), 505-514, 2021年03月, 査読有り

Role of G Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic Treatment of Non-Alcoholic Fatty Liver Disease
Kimura, Takefumi; Singh, Simran; Tanaka, Naoki; Umemura, Takeji;
FRONTIERS IN ENDOCRINOLOGY, 12, 773432, 2021年

A saturated fatty acid-rich diet enhances hepatic lipogenesis and tumorigenesis in HCV core gene transgenic mice
Diao, Pan; Wang, Xiaojing; Jia, Fangping; Kimura, Takefumi; Hu, Xiao; Shirotori, Saki; Nakamura, Ibuki; Sato, Yoshiko; Nakayama, Jun; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Aoyama, Toshifumi; Tanaka, Naoki;
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 85, 2020年11月

Invasive liver abscess syndrome accompanied by spondylodiscitis: a case report and review of the literature
Wakabayashi SI, Kimura T, Tanaka N, Pham J, Tanaka T, Higuchi S, Kobayashi J, Umemura T, Iijima A.
Clin J Gastroenterol, 13(5), 927-934, 2020年10月, 査読有り

Metabolic Functions of G Protein-Coupled Receptors in Hepatocytes-Potential Applications for Diabetes and NAFLD
Kimura, Takefumi; Pydi, Sai P.; Pham, Jonathan; Tanaka, Naoki;
BIOMOLECULES, 10(10), 2020年10月

Non-alcoholic fatty liver disease later diagnosed as myotonic dystrophy
Tanaka N, Kimura T, Fujimori N, Ichise Y, Sano K, Horiuchi A.
World J Hepatol. 2020 Sep 27;12(9):685-692. doi: 10.4254/wjh.v12.i9.685., 12(9), 685-692, 2020年09月, 査読有り
筆頭著者, 責任著者

Acute liver failure with severe steatosis induced by mushroom
Wakabayashi, Shun-ichi; Kimura, Takefumi; Tanaka, Naoki;
LIVER INTERNATIONAL, 40(9), 2291-2292, 2020年09月

Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice
Jia, Fangping; Diao, Pan; Wang, Xiaojing; Hu, Xiao; Kimura, Takefumi; Nakamuta, Makoto; Nakamura, Ibuki; Shirotori, Saki; Sato, Yoshiko; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Nakayama, Jun; Aoyama, Toshifumi; Tanaka, Naoki;
Liver Cancer, 9(5), 529-548, 2020年09月

Polyunsaturated fatty acid deficiency affects sulfatides and other sulfated glycans in lysosomes through autophagy-mediated degradation
Wang, Yaping; Nakajima, Takero; Diao, Pan; Yamada, Yosuke; Nakamura, Kozo; Nakayama, Jun; Tanaka, Naoki; Aoyama, Toshifumi; Kamijo, Yuji;
FASEB JOURNAL, 34(7), 9594-9614, 2020年07月

Congestive hepatopathy and acute pancreatitis as severe complications of mixed connective tissue disease
Kurihara S, Kimura T, Tanaka N, Yanagisawa T, Kobayashi H, Kanai K, Umemura T, Kobayashi M, Mori H, Wada S.
Clin J Gastroenterol, 13(3), 434-442, 2020年06月, 査読有り

PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice
Wang, Yaping; Nakajima, Takero; Gonzalez, Frank J.; Tanaka, Naoki;
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(6), 2020年03月

Long-term luseogliflozin therapy improves histological activity of non-alcoholic steatohepatitis accompanied by type 2 diabetes mellitus
Fujimori N, Tanaka N, Kimura T, Sano K, Horiuchi A, Kato N, Takahashi Y, Kuribayashi N, Sugiura A, Yamazaki T, Joshita S, Umemura T, Matsumoto A, Tanaka E.
Clin J Gastroenterol, 13(1), 83-89, 2020年02月, 査読有り
責任著者

A trans-fatty acid-rich diet promotes liver tumorigenesis in HCV core gene transgenic mice
Hu, Xiao; Wang, Xiaojing; Jia, Fangping; Tanaka, Naoki; Kimura, Takefumi; Nakajima, Takero; Sato, Yoshiko; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Nakayama, Jun; Aoyama, Toshifumi;
CARCINOGENESIS, 41(2), 159-170, 2020年02月

Cold snare polypectomy: Indications, devices, techniques, outcomes and future
Horiuchi, Akira; Ikuse, Tamaki; Tanaka, Naoki;
DIGESTIVE ENDOSCOPY, 31(4), 372-377, 2019年07月

A high-cholesterol diet promotes steatohepatitis and liver tumorigenesis in HCV core gene transgenic mice
Wang, Xiaojing; Tanaka, Naoki; Hu, Xiao; Kimura, Takefumi; Lu, Yu; Jia, Fangping; Sato, Yoshiko; Nakayama, Jun; Moriya, Kyoji; Koike, Kazuhiko; Aoyama, Toshifumi;
ARCHIVES OF TOXICOLOGY, 93(6), 1713-1725, 2019年06月

Safety and Effectiveness of Nurse-Administered Propofol Sedation in Outpatients Undergoing Gastrointestinal Endoscopy
Sato, Masamichi; Horiuchi, Akira; Tamaki, Michio; Ichise, Yasuyuki; Kajiyama, Masashi; Yamamoto, Yuta; Tanaka, Naoki;
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 17(6), 1098-+, 2019年05月

Red plasma and ascites under ultraviolet A
Wakabayashi, Shun-ichi; Kimura, Takefumi; Tanaka, Naoki; Komatsu, Michiharu; Tanaka, Eiji;
LANCET GASTROENTEROLOGY & HEPATOLOGY, 4(4), 324-324, 2019年04月

Peroxisome proliferator-activated receptor attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice
Lu, Yu; Harada, Makoto; Kamijo, Yuji; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kyogashima, Mamoru; Gonzalez, Frank J.; Aoyama, Toshifumi;
ARCHIVES OF TOXICOLOGY, 93(1), 149-161, 2019年01月

Gastric Emptying of Elemental Liquid Diets Versus Semisolid Diets in Bedridden Gastrostomy-fed Patients
Horiuchi, Akira; Sakai, Ryosei; Tamaki, Michio; Kajiyama, Masashi; Tanaka, Naoki; Morikawa, Akio;
JOURNAL OF CLINICAL GASTROENTEROLOGY, 53(5), 373-378, 2019年

Current status, problems, and perspectives of non-alcoholic fatty liver disease research
Tanaka, Naoki; Kimura, Takefumi; Fujimori, Naoyuki; Nagaya, Tadanobu; Komatsu, Michiharu; Tanaka, Eiji;
WORLD JOURNAL OF GASTROENTEROLOGY, 25(2), 163-177, 2019年

Miglitol attenuates non-alcoholic steatohepatitis in diabetic patients
Komatsu, Michiharu; Tanaka, Naoki; Kimura, Takefumi; Fujimori, Naoyuki; Sano, Kenji; Horiuchi, Akira; Sugiura, Ayumi; Yamazaki, Tomoo; Shibata, Soichiro; Joshita, Satoru; Umemura, Takeji; Matsumoto, Akihiro; Tanaka, Eiji;
HEPATOLOGY RESEARCH, 48(13), 1092-1098, 2018年12月

Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development.
Takahashi S, Tanaka N, Fukami T, Xie C, Yagai T, Kim D, Velenosi TJ, Yan T, Krausz KW, Levi M, Gonzalez FJ.
Hepatol Commun, 2(12), 1567-1582, 2018年10月

Emergence of anti-mitochondrial M2 antibody in patient with angioimmunoblastic T-cell lymphoma.
Wakabayashi SI, Kimura T, Tanaka N, Joshita S, Kawata K, Umemura T, Hiroshima Y, Mori H, Kobayashi H, Wada S, Tanaka E.
Clin J Gastroenterol, 11(4), 302-308, 2018年08月

Delayed Bleeding Following Cold Snare Polypectomy for Small Colorectal Polyps in Patients Taking Antithrombotic Agents
Makino, Toshiyuki; Horiuchi, Akira; Kajiyama, Masashi; Tanaka, Naoki; Sano, Kenji; Maetani, Iruru;
JOURNAL OF CLINICAL GASTROENTEROLOGY, 52(6), 502-507, 2018年07月

Salmonella Enteritidis cholecystitis with chronic granulomatous disease.
Yamashita Y, Kimura T, Tanaka N, Yazaki M, Itagaki T, Joshita S, Umemura T, Matsumoto A, Mori H, Wada S, Tanaka E.
IDCases, 12, 12:49-52, 2018年05月

Mild drinking habit is a risk factor for hepatocarcinogenesis in non-alcoholic fatty liver disease with advanced fibrosis
Kimura, Takefumi; Tanaka, Naoki; Fujimori, Naoyuki; Sugiura, Ayumi; Yamazaki, Tomoo; Joshita, Satoru; Komatsu, Michiharu; Umemura, Takeji; Matsumoto, Akihiro; Tanaka, Eiji;
WORLD JOURNAL OF GASTROENTEROLOGY, 24(13), 1440-1450, 2018年04月

Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease
Fujimori, Naoyuki; Umemura, Takeji; Kimura, Takefumi; Tanaka, Naoki; Sugiura, Ayumi; Yamazaki, Tomoo; Joshita, Satoru; Komatsu, Michiharu; Usami, Yoko; Sano, Kenji; Igarashi, Koji; Matsumoto, Akihiro; Tanaka, Eiji;
WORLD JOURNAL OF GASTROENTEROLOGY, 24(11), 1239-1249, 2018年03月

Hepatic Angiosarcoma with Kasabach-Merritt Phenomenon: A Case Report and Review of the Literature
Fujii, Fumika; Kimura, Takefumi; Tanaka, Naoki; Kubota, Daisuke; Sugiura, Ayumi; Umemura, Takeji; Wada, Shuichi; Tanaka, Eiji;
ANNALS OF HEPATOLOGY, 17(4), 655-660, 2018年

Growth arrest and DNA damage-inducible 45 alpha protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet
Tanaka, Naoki; Takahashi, Shogo; Hu, Xiao; Lu, Yu; Fujimori, Naoyuki; Golla, Srujana; Fang, Zhong-Ze; Aoyama, Toshifumi; Krausz, Kristopher W.; Gonzalez, Frank J.;
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1863(12), 3170-3182, 2017年12月

Targeting nuclear receptors for the treatment of fatty liver disease
Tanaka, Naoki; Aoyama, Toshifumi; Kimura, Shioko; Gonzalez, Frank J.;
PHARMACOLOGY & THERAPEUTICS, 179, 142-157, 2017年11月

Association between lower air pressure and the onset of ischemic colitis: a case-control study
Kimura, Takefumi; Shinji, Akihiro; Tanaka, Naoki; Koinuma, Masayoshi; Yamaura, Maki; Nagaya, Tadanobu; Joshita, Satoru; Komatsu, Michiharu; Umemura, Takeji; Horiuchi, Akira; Wada, Shuichi; Tanaka, Eiji;
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 29(9), 1071-1078, 2017年09月

Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway
Takahashi, Shogo; Tanaka, Naoki; Golla, Srujana; Fukami, Tatsuki; Krausz, Kristopher W.; Polunas, Marianne A.; Weig, Blair C.; Masuo, Yusuke; Xie, Cen; Jiang, Changtao; Gonzalez, Frank J.;
Toxicological Sciences, 158(2), 334-346, 2017年08月

Decreased Fatty Acid beta-Oxidation Is the Main Cause of Fatty Liver Induced by Polyunsaturated Fatty Acid Deficiency in Mice
Nakajima, Takero; Yang, Yang; Lu, Yu; Kamijo, Yuji; Yamada, Yosuke; Nakamura, Kozo; Koyama, Masahiro; Yamaguchi, Shohei; Sugiyama, Eiko; Tanaka, Naoki; Aoyama, Toshifumi;
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 242(3), 229-239, 2017年07月

Role of the lipid-regulated NF-kappa B/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury
Fang, Zhong-Ze; Tanaka, Naoki; Lu, Dan; Jiang, Chang-Tao; Zhang, Wei-Hua; Zhang, Chunze; Du, Zuo; Fu, Zhi-Wei; Gao, Peng; Cao, Yun-Feng; Sun, Hong-Zhi; Zhu, Zhi-Tu; Cai, Yan; Krausz, Kristopher W.; Yao, Zhi; Gonzalez, Frank J.;
ARCHIVES OF TOXICOLOGY, 91(5), 2235-2244, 2017年05月

Clinicopathological characteristics of non-B non-C hepatocellular carcinoma without past hepatitis B virus infection
Kimura, Takefumi; Kobayashi, Akira; Tanaka, Naoki; Sano, Kenji; Komatsu, Michiharu; Fujimori, Naoyuki; Yamazaki, Tomoo; Shibata, Soichiro; Ichikawa, Yuki; Joshita, Satoru; Umemura, Takeji; Matsumoto, Akihiro; Horiuchi, Akira; Mori, Hiromitsu; Wada, Shuichi; Kiyosawa, Kendo; Miyagawa, Shin-ichi; Tanaka, Eiji;
HEPATOLOGY RESEARCH, 47(5), 405-418, 2017年04月

PPAR alpha protects against trans-fatty-acid-containing diet-induced steatohepatitis
Hu, Xiao; Tanaka, Naoki; Guo, Ran; Lu, Yu; Nakajima, Takero; Gonzalez, Frank J.; Aoyama, Toshifumi;
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 39, 77-85, 2017年01月

Association between endotoxemia and histological features of nonalcoholic fatty liver disease
Kitabatake, Hiroyuki; Tanaka, Naoki; Fujimori, Naoyuki; Komatsu, Michiharu; Okubo, Ayaka; Kakegawa, Kyogo; Kimura, Takefumi; Sugiura, Ayumi; Yamazaki, Tomoo; Shibata, Soichiro; Ichikawa, Yuki; Joshita, Satoru; Umemura, Takeji; Matsumoto, Akihiro; Koinuma, Masayoshi; Sano, Kenji; Aoyama, Toshifumi; Tanaka, Eiji;
WORLD JOURNAL OF GASTROENTEROLOGY, 23(4), 712-722, 2017年

Vonoprazan-Based Regimen Is More Useful than PPI-Based One as a First-Line Helicobacter pylori Eradication: A Randomized Controlled Trial
Maruyama, Masafumi; Tanaka, Naoki; Kubota, Daisuke; Miyajima, Masayuki; Kimura, Takefumi; Tokutake, Koujiro; Imai, Ryujiro; Fujisawa, Toru; Mori, Hiromitsu; Matsuda, Yoshiaki; Wada, Shuichi; Horiuchi, Akira; Kiyosawa, Kendo;
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2017年

Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption
Wang, Haina; Fang, Zhong-Ze; Meng, Ran; Cao, Yun-Feng; Tanaka, Naoki; Krausz, Kristopher W.; Gonzalez, Frank J.;
Toxicology, 386, 133-142, 2017年

Age-dependent PPAR alpha activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene
Tian, Yangyang; Yang, Yang; Zhang, Xiaowei; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kamijo, Yuji; Lu, Yu; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Aoyama, Toshifumi;
GLYCOCONJUGATE JOURNAL, 33(6), 927-936, 2016年12月

PPAR alpha-dependent cholesterol/testosterone disruption in Leydig cells mediates 2,4-dichlorophenoxyacetic acid-induced testicular toxicity in mice
Harada, Yukiko; Tanaka, Naoki; Ichikawa, Motoki; Kamijo, Yuji; Sugiyama, Eiko; Gonzalez, Frank J.; Aoyama, Toshifumi;
ARCHIVES OF TOXICOLOGY, 90(12), 3061-3071, 2016年12月

Activation of PPAR alpha by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis
Yang, Yang; Feng, Yuyao; Zhang, Xiaowei; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kamijo, Yuji; Aoyama, Toshifumi;
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 240(2), 113-122, 2016年10月

Controlled attenuation parameter is correlated with actual hepatic fat content in patients with non-alcoholic fatty liver disease with none-to-mild obesity and liver fibrosis
Fujimori, Naoyuki; Tanaka, Naoki; Shibata, Soichiro; Sano, Kenji; Yamazaki, Tomoo; Sekiguchi, Tomohiro; Kitabatake, Hiroyuki; Ichikawa, Yuki; Kimura, Takefumi; Komatsu, Michiharu; Umemura, Takeji; Matsumoto, Akihiro; Tanaka, Eiji;
HEPATOLOGY RESEARCH, 46(10), 1019-1027, 2016年09月

Comparison between endoscopic mucosal resection and hot snare resection of large nonpedunculated colorectal polyps: a randomized trial
Horiuchi, Akira; Makino, Toshiyuki; Kajiyama, Masashi; Tanaka, Naoki; Sano, Kenji; Graham, David Y.;
ENDOSCOPY, 48(7), 646-651, 2016年07月

Irinotecan (CPT-11)-induced elevation of bile acids potentiates suppression of IL-10 expression
Fang, Zhong-Ze; Zhang, Dunfang; Cao, Yun-Feng; Xie, Cen; Lu, Dan; Sun, Dong-Xue; Tanaka, Naoki; Jiang, Changtao; Chen, Qianming; Chen, Yu; Wang, Haina; Gonzalez, Frank J.;
Toxicology and Applied Pharmacology, 291, 21-27, 2016年

Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans
Xu, Ming-Jiang; Cai, Yan; Wang, Hua; Altamirano, Jose; Chang, Binxia; Bertola, Adeline; Odena, Gemma; Lu, Jim; Tanaka, Naoki; Matsusue, Kimihiko; Matsubara, Tsutomu; Mukhopadhyay, Partha; Kimura, Shioko; Pacher, Pal; Gonzalez, Frank J.; Bataller, Ramon; Gao, Bin;
GASTROENTEROLOGY, 149(4), 1030-U367, 2015年10月

Prospective, randomized comparison of 2 methods of cold snare polypectomy for small colorectal polyps
Horiuchi, Akira; Hosoi, Kenji; Kajiyama, Masashi; Tanaka, Naoki; Sano, Kenji; Graham, David Y.;
GASTROINTESTINAL ENDOSCOPY, 82(4), 686-692, 2015年10月

St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling
Manna, Soumen K.; Golla, Srujana; Golla, Jaya Prakash; Tanaka, Naoki; Cai, Yan; Takahashi, Shogo; Krausz, Kristopher W.; Matsubara, Tsutomu; Korboukh, Ilia; Gonzalez, Frank J.;
CANCER PREVENTION RESEARCH, 8(9), 786-795, 2015年09月

Primary hepatocellular carcinoma in a patient with neurofibromatosis type I
Kimura, Takefumi; Tanaka, Naoki; Umemura, Takeji; Tanaka, Eiji;
LIVER INTERNATIONAL, 35(8), 2057-2058, 2015年08月

Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet
Tanaka, Naoki; Takahashi, Shogo; Zhang, Yuan; Krausz, Kristopher W.; Smith, Philip B.; Patterson, Andrew D.; Gonzalez, Frank J.;
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1852(7), 1242-1252, 2015年07月

Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation
Zhang, Limin; Nichols, Robert G.; Correll, Jared; Murray, Iain A.; Tanaka, Naoki; Smith, Philip B.; Hubbard, Troy D.; Sebastian, Aswathy; Albert, Istvan; Hatzakis, Emmanuel; Gonzalez, Frank J.; Perdew, Gary H.; Patterson, Andrew D.;
ENVIRONMENTAL HEALTH PERSPECTIVES, 123(7), 679-688, 2015年07月

Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPAR alpha
Komatsu, Michiharu; Kimura, Takefumi; Yazaki, Masahide; Tanaka, Naoki; Yang, Yang; Nakajima, Takero; Horiuchi, Akira; Fang, Zhong-Ze; Joshita, Satoru; Matsumoto, Akihiro; Umemura, Takeji; Tanaka, Eiji; Gonzalez, Frank J.; Ikeda, Shu-Ichi; Aoyama, Toshifumi;
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1852(3), 473-481, 2015年03月

Comparison of newly found polyps after removal of small colorectal polyps with cold or hot snare polypectomy
Horiuchi, Akira; Makino, Toshiyuki; Ichise, Yasuyuki; Kajiyama, Masashi; Kato, Naoyuki; Tanaka, Naoki;
ACTA GASTRO-ENTEROLOGICA BELGICA, 78(4), 406-410, 2015年

Metabolic mapping of A(3) adenosine receptor agonist MRS5980
Fang, Zhong-Ze; Tosh, Dilip K.; Tanaka, Naoki; Wang, Haina; Krausz, Kristopher W.; O'Connor, Robert; Jacobson, Kenneth A.; Gonzalez, Frank J.;
Biochemical Pharmacology, 97(2), 215-223, 2015年

Adipocyte-specific Disruption of Fat-specific Protein 27 Causes Hepatosteatosis and Insulin Resistance in High-fat Diet-fed Mice
Tanaka, Naoki; Takahashi, Shogo; Matsubara, Tsutomu; Jiang, Changtao; Sakamoto, Wataru; Chanturiya, Tatyana; Teng, Ruifeng; Gavrilova, Oksana; Gonzalez, Frank J.;
JOURNAL OF BIOLOGICAL CHEMISTRY, 290(5), 3092-3105, 2015年

Helicobacter pylori-negative Differentiated Adenocarcinoma of the Stomach
Nagaya, Tadanobu; Tanaka, Naoki; Iwaya, Yugo; Jimbo, Yoko; Tatai, Toshiharu; Ito, Tetsuya; Seki, Ayako; Suzawa, Kenichi; Ochi, Yasuhide; Hara, Etsuo; Takata, Manabu; Otsuki, Toshiaki; Iwaya, Mai; Hosaka, Noriko; Arakura, Norikazu; Tanaka, Eiji; Hasebe, Osamu;
INTERNAL MEDICINE, 54(22), 2857-2862, 2015年

Activation of Intestinal Human Pregnane X Receptor Protects against Azoxymethane/Dextran Sulfate Sodium-Induced Colon Cancer
Cheng, Jie; Fang, Zhong-Ze; Nagaoka, Kenjiro; Okamoto, Minoru; Qu, Aijuan; Tanaka, Naoki; Kimura, Shioko; Gonzalez, Frank J.;
Journal of Pharmacology and Experimental Therapeutics, 351(3), 559-567, 2014年12月

Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet
Tanaka, Naoki; Takahashi, Shogo; Fang, Zhong-Ze; Matsubara, Tsutomu; Krausz, Kristopher W.; Qu, Aijuan; Gonzalez, Frank J.;
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1841(11), 1596-1607, 2014年11月

Biliary stenting as alternative therapy to stone clearance in elderly patients with bile duct stones
Horiuchi, Akira; Kajiyama, Masashi; Ichise, Yasuyuki; Tada, Haruyo; Fujiwara, Naoyuki; Tanaka, Naoki;
ACTA GASTRO-ENTEROLOGICA BELGICA, 77(3), 297-301, 2014年09月

Laparoscopic findings of congenital hepatic fibrosis: A case report and review of the published work
Komatsu, Michiharu; Tanaka, Naoki; Shibata, So-Ichirou; Kimura, Takefumi; Ichikawa, Yuki; Morita, Susumu; Joshita, Satoru; Nagaya, Tadanobu; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Tanaka, Eiji;
HEPATOLOGY RESEARCH, 44(7), 818-824, 2014年07月

Biomarkers of Coordinate Metabolic Reprogramming in Colorectal Tumors in Mice and Humans
Manna, Soumen K.; Tanaka, Naoki; Krausz, Kristopher W.; Haznadar, Majda; Xue, Xiang; Matsubara, Tsutomu; Bowman, Elise D.; Fearon, Eric R.; Harris, Curtis C.; Shah, Yatrik M.; Gonzalez, Frank J.;
GASTROENTEROLOGY, 146(5), 1313-1324, 2014年05月

In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract
Fang, Zhong-Ze; Krausz, Kristopher W.; Nagaoka, Kenjiro; Tanaka, Naoki; Gowda, Krishne; Amin, Shantu G.; Perdew, Gary H.; Gonzalez, Frank J.;
British Journal of Pharmacology, 171(7), 1735-1746, 2014年04月

Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice
Cheng, Jie; Fang, Zhong-Ze; Kim, Jung-Hwan; Krausz, Kristopher W.; Tanaka, Naoki; Chiang, John Y. L.; Gonzalez, Frank J.;
Journal of Lipid Research, 55(3), 455-465, 2014年03月

Removal of small colorectal polyps in anticoagulated patients: a prospective randomized comparison of cold snare and conventional polypectomy
Horiuchi, Akira; Nakayama, Yoshiko; Kajiyama, Masashi; Tanaka, Naoki; Sano, Kenji; Graham, David Y.;
GASTROINTESTINAL ENDOSCOPY, 79(3), 417-423, 2014年03月

Role of Myc in hepatocellular proliferation and hepatocarcinogenesis
Qu, Aijuan; Jiang, Changtao; Cai, Yan; Kim, Jung-Hwan; Tanaka, Naoki; Ward, Jerrold M.; Shah, Yatrik M.; Gonzalez, Frank J.;
JOURNAL OF HEPATOLOGY, 60(2), 331-338, 2014年02月

Chronic ethanol consumption decreases serum sulfatide levels by suppressing hepatic cerebroside sulfotransferase expression in mice
Kanbe, Hiroki; Kamijo, Yuji; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Wang, Lixuan; Fang, Zhong-Ze; Hara, Atsushi; Gonzalez, Frank J.; Aoyama, Toshifumi;
ARCHIVES OF TOXICOLOGY, 88(2), 367-379, 2014年02月

Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-kappa B and STAT3 signaling
Liu, Aiming; Tanaka, Naoki; Sun, Lu; Guo, Bin; Kim, Jung-Hwan; Krausz, Kristopher W.; Fang, Zhongze; Jiang, Changtao; Yang, Julin; Gonzalez, Frank J.;
CHEMICO-BIOLOGICAL INTERACTIONS, 223, 80-86, 2014年

Improving quality measures in colonoscopy and its therapeutic intervention
Horiuchi, Akira; Tanaka, Naoki;
WORLD JOURNAL OF GASTROENTEROLOGY, 20(36), 13027-13034, 2014年

PPAR alpha-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate
Qi, Yunpeng; Jiang, Changtao; Tanaka, Naoki; Krausz, Kristopher W.; Brocker, Chad N.; Fang, Zhong-Ze; Bredell, Bryce X.; Shah, Yatrik M.; Gonzalez, Frank J.;
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 307(5), G564-G573, 2014年

Herb-drug interaction prediction based on the high specific inhibition of andrographolide derivatives towards UDP-glucuronosyltransferase (UGT) 2B7
Ma, Hai-Ying; Sun, Dong-Xue; Cao, Yun-Feng; Ai, Chun-Zhi; Qu, Yan-Qing; Hu, Cui-Min; Jiang, Changtao; Dong, Pei-Pei; Sun, Xiao-Yu; Hong, Mo; Tanaka, Naoki; Gonzalez, Frank J.; Ma, Xiao-Chi; Fang, Zhong-Ze;
Toxicology and Applied Pharmacology, 277(1), 86-94, 2014年

A model of in vitro UDP-glucuronosyltransferase inhibition by bile acids predicts possible metabolic disorders
Fang, Zhong-Ze; He, Rong-Rong; Cao, Yun-Feng; Tanaka, Naoki; Jiang, Changtao; Krausz, Kristopher W.; Qi, Yunpeng; Dong, Pei-Pei; Ai, Chun-Zhi; Sun, Xiao-Yu; Hong, Mo; Ge, Guang-Bo; Gonzalez, Frank J.; Ma, Xiao-Chi; Sun, Hong-Zhi;
Journal of Lipid Research, 54(12), 3334-3344, 2013年12月

Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum
Fang, Zhong-Ze; Krausz, Kristopher W.; Tanaka, Naoki; Li, Fei; Qu, Aijuan; Idle, Jeffrey R.; Gonzalez, Frank J.
ARCHIVES OF TOXICOLOGY, 87(11), 1975-1987, 2013年11月

Peroxisome proliferator-activated receptor alpha mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs
Nakajima, Takero; Kamijo, Yuji; Huang Yuzhe; Kimura, Takefumi; Tanaka, Naoki; Sugiyama, Eiko; Nakamura, Kozo; Kyogashima, Mamoru; Hara, Atsushi; Aoyama, Toshifumi;
GLYCOCONJUGATE JOURNAL, 30(6), 553-560, 2013年08月

Safety and Effectiveness of Low-Dose Propofol Sedation During and After Esophagogastroduodenoscopy in Child A and B Cirrhotic Patients
Tanaka, Naoki; Horiuchi, Akira; Nakayama, Yoshiko; Katsuyama, Yoshihiko; Isobe, Masatsugu; Aoyama, Toshifumi; Tanaka, Eiji; Ohmori, Shigeru
DIGESTIVE DISEASES AND SCIENCES, 58(5), 1383-1389, 2013年05月

TGF-beta-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury
Matsubara, Tsutomu; Tanaka, Naoki; Sato, Misako; Kang, Dong Wook; Krausz, Kristopher W.; Flanders, Kathleen C.; Ikeda, Kazuo; Luecke, Hans; Wakefield, Lalage M.; Gonzalez, Frank J.
Journal of Lipid Research, 53(12), 2698-2707, 2012年12月

Metabolomics Identifies an Inflammatory Cascade Involved in Dioxin- and Diet-Induced Steatohepatitis
Matsubara, Tsutomu; Tanaka, Naoki; Krausz, Kristopher W.; Manna, Soumen K.; Kang, Dong Wook; Anderson, Erik R.; Luecke, Hans; Patterson, Andrew D.; Shah, Yatrik M.; Gonzalez, Frank J.
Cell Metabolism, 16(5), 634-644, 2012年11月07日

Metabolomics reveals an essential role for peroxisome proliferator-activated receptor alpha in bile acid homeostasis
Li, Fei; Patterson, Andrew D.; Krausz, Kristopher W.; Tanaka, Naoki; Gonzalez, Frank J.
Journal of Lipid Research, 53(8), 1625-1635, 2012年08月

Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis
Tanaka, Naoki; Matsubara, Tsutomu; Krausz, Kristopher W.; Patterson, Andrew D.; Gonzalez, Frank J.
Hepatology, 56(1), 118-129, 2012年07月

Clinical characteristics of young-onset ischemic colitis
Kimura, Takefumi; Shinji, Akihiro; Horiuchi, Akira; Tanaka, Naoki; Nagaya, Tadanobu; Shigeno, Takashi; Nakamura, Naoshi; Komatsu, Michiharu; Umemura, Takeji; Arakura, Norikazu; Matsumoto, Akihiro; Tanaka, Eiji
DIGESTIVE DISEASES AND SCIENCES, 57(6), 1652-1659, 2012年06月

PPAR alpha is down-regulated following liver transplantation in mice
Nakagawa, Kan; Tanaka, Naoki; Morita, Miwa; Sugioka, Atsushi; Miyagawa, Shin-ichi; Gonzalez, Frank J.; Aoyama, Toshifumi
JOURNAL OF HEPATOLOGY, 56(3), 586-594, 2012年03月

Clinical characteristics of de novo nonalcoholic fatty liver disease following pancreaticoduodenectomy
Tanaka, Naoki; Horiuchi, Akira;Yokoyama, Takahide; Kaneko, Gengo; Horigome, Naoto; Yamaura, Takahiro; Nagaya, Tadanobu; Komatsu, Michiharu; Sano, Kenji; Miyagawa, Shin-ichi; Aoyama, Toshifumi; Tanaka, Eiji
JOURNAL OF GASTROENTEROLOGY, 46(6), 758-768, 2011年06月

Lithocholic Acid Disrupts Phospholipid and Sphingolipid Homeostasis Leading to Cholestasis in Mice
Matsubara, Tsutomu; Tanaka, Naoki; Patterson, Andrew D.; Cho, Joo-Youn; Krausz, Kristopher W.; Gonzalez, Frank J.
Hepatology, 53(4), 1282-1293, 2011年04月

Accurate and simple method for quantification of hepatic fat content using magnetic resonance imaging: a prospective study in biopsy-proven nonalcoholic fatty liver disease
Hatta, Tomoko; Fujinaga, Yasunari; Kadoya, Masumi; Ueda, Hitoshi; Murayama, Hiroaki; Kurozumi, Masahiro; Ueda, Kazuhiko; Komatsu, Michiharu; Nagaya, Tadanobu; Joshita, Satoru; Kodama, Ryo; Tanaka, Eiji; Uehara, Tsuyoshi; Sano, Kenji; Tanaka, Naoki
JOURNAL OF GASTROENTEROLOGY, 45(12), 1263-1271, 2010年12月

Eicosapentaenoic acid improves hepatic steatosis independent of PPAR alpha activation through inhibition of SREBP-1 maturation in mice
Tanaka, Naoki; Zhang, Xiuguo; Sugiyama, Eiko; Kono, Hiroyuki; Horiuchi, Akira; Nakajima, Takero; Kanbe, Hiroki; Tanaka, Eiji; Gonzalez, Frank J.; Aoyama, Toshifumi
Biochemical Pharmacology, 80(10), 1601-1612, 2010年11月15日

Down-regulation of SREBP-1c is associated with the development of burned-out NASH
Nagaya, Tadanobu; Tanaka, Naoki; Suzuki, Takefumi; Sano, Kenji; Horiuchi, Akira; Komatsu, Michiharu; Nakajima, Takero; Nishizawa, Tomoko; Joshita, Satoru; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Nakayama, Jun; Tanaka, Eiji; Aoyama, Toshifumi
JOURNAL OF HEPATOLOGY, 53(4), 724-731, 2010年10月

Serum Fragmented Cytokeratin 18 Levels Reflect the Histologic Activity Score of Nonalcoholic Fatty Liver Disease More Accurately Than Serum Alanine Aminotransferase Levels
Tsutsui, Masaru; Tanaka, Naoki; Kawakubo, Masatomo; Sheena, Yo; Horiuchi, Akira; Komatsu, Michiharu; Nagaya, Tadanobu; Joshita, Satoru; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Aoyama, Toshifumi; Tanaka, Eiji; Sano, Kenji
JOURNAL OF CLINICAL GASTROENTEROLOGY, 44(6), 440-447, 2010年07月

Nonalcoholic fatty liver disease in Japanese junior high school students: its prevalence and relationship to lifestyle habits
Tsuruta, Goro; Tanaka, Naoki; Hongo, Minoru; Komatsu, Michiharu; Horiuchi, Akira; Hamamoto, Kaeko; Iguchi, Chieko; Nakayama, Yoshiko; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Aoyama, Toshifumi; Tanaka, Eiji
JOURNAL OF GASTROENTEROLOGY, 45(6), 666-672, 2010年06月

一般中学生の高尿酸血症と生活習慣病との関連
本郷 実,日高 宏哉,阪口 しげ子,市川 元基,池田 宇一,田中 直樹,鶴田 悟郎,小池 健一
痛風と核酸代謝 = Gout and nucleic acid metabolism, 33(1), 17-26, 2009年07月01日

Polyenephosphatidylcholine prevents alcoholic liver disease in PPAR alpha-null mice through attenuation of increases in oxidative stress
Okiyama, Wataru; Tanaka, Naoki; Nakajima, Tamie; Tanaka, Eiji; Kiyosawa, Kendo; Gonzalez, Frank J.; Aoyama, Toshifumi
JOURNAL OF HEPATOLOGY, 50(6), 1236-1246, 2009年06月

Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections
Tanaka, Naoki; Horiuchi, Akira; Yamaura, Takahiro; Komatsu, Michiharu; Yokoyama, Takahide; Okaniwa, Shinji; Nagaya, Tadanobu; Yoshizawa, Kaname; Kiyosawa, Kendo; Aoyama, Toshifumi; Tanaka, Eiji
JOURNAL OF GASTROENTEROLOGY, 44(6), 577-582, 2009年06月

Bezafibrate at Clinically Relevant Doses Decreases Serum/Liver Triglycerides via Down-Regulation of Sterol Regulatory Element-Binding Protein-1c in Mice: A Novel Peroxisome Proliferator-Activated Receptor alpha-Independent Mechanism
Nakajima, Takero; Tanaka, Naoki; Kanbe, Hiroki; Hara, Atsushi; Kamijo, Yuji; Zhang, Xiaowei; Gonzalez, Frank J.; Aoyama, Toshifumi
MOLECULAR PHARMACOLOGY, 75(4), 782-792, 2009年04月

Hepatitis C Virus, Splenic Vein Thrombosis, and Lymphoma
Tanaka, Naoki; Yokoyama, Takahide; Horiuchi, Akira
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 7(2), XXIV-XXIV, 2009年02月

広範囲の肝実質の脱落により奇異な肝形態を呈し自己免疫性肝炎が疑われた1例
城下 智,一條 哲也,吉澤 要,福島 万奈,小松 通治,新井 薫,田中 直樹,梅村 武司,松本 晶博,田中 榮司
日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy, 51(1), 48-54, 2009年01月20日

α型ペルオキシソーム増殖剤活性化受容体（PPARα）： 脂肪肝疾患との関連
田中直樹,青山俊文
信州医学雑誌, 56(6), 347-358, 2008年12月

Citrin deficiency as a cause of chronic liver disorder mimicking non-alcoholic fatty liver disease
Komatsu, Michiharu; Yazaki, Masahide; Tanaka, Naoki; Sano, Kenji; Hashimoto, Etsuko; Taker, Yo-ichi; Song, Yuan-Zong; Tanaka, Eiji; Kiyosawa, Kendo; Saheki, Takeyori; Aoyama, Toshifumi; Kobayashi, Keiko
JOURNAL OF HEPATOLOGY, 49(5), 810-820, 2008年11月

Insulin resistance and hepatitis C virus: a case-control study of non-obese, non-alcoholic and non-steatotic hepatitis virus carriers with persistently normal serumaminotransferase
Tanaka, Naoki; Nagaya, Tadanobu; Komatsu, Michiharu; Horiuchi, Akira; Tsuruta, Goro; Shirakawa, Haruaki; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Aoyama, Toshifumi; Kiyosawa, Kendo; Tanaka, Eiji
LIVER INTERNATIONAL, 28(8), 1104-1111, 2008年09月

Cholesterol-lowering effectof bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice
Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kamijo, Yuji; Hara, Atsushi; Hu, Rui; Li, Gang; Li, Yufeng; Nakamura, Kozo; Gonzalez, Frank J.; Aoyama, Toshifumi
Biochemical Pharmacology, 76(1), 108-119, 2008年07月01日

Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohepatitis
Tanaka, Naoki; Sano, Kenji; Horiuchi, Akira; Tanaka, Eiji; Kiyosawa, Kendo; Aoyama, Toshifumi
JOURNAL OF CLINICAL GASTROENTEROLOGY, 42(4), 413-418, 2008年04月

PPAR alpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice
Tanaka, Naoki; Moriya, Kyoji; Kiyosawa, Kendo; Koike, Kazuhiko; Gonzalez, Frank J.; Aoyama, Toshifurni
JOURNAL OF CLINICAL INVESTIGATION, 118(2), 683-694, 2008年02月

Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: Implications for HCV-associated hepatocarcinogenesis
Tanaka, Naoki; Moriya, Kyoji; Kiyosawa, Kendo; Koike, Kazuhiko; Aoyama, Toshifumi
INTERNATIONAL JOURNAL OF CANCER, 122(1), 124-131, 2008年01月01日

Pancreatic exocrine insufficiency: A rare cause of nonalcoholic steatohepatitis
Tanaka, Naoki; Horiuchi, Akira; Yokoyama, Takahide; Kawa, Shigeyuki; Kiyosawa, Kendo
AMERICAN JOURNAL OF GASTROENTEROLOGY, 103(1), 245-246, 2008年01月

腹壁への浸潤が疑われ, 画像検査が診断の契機となった肝放線菌症の1例
武藤 英知,一條 哲也,小林 倫子,田中 直樹,梅村 武司,小松 通治,松本 晶博,吉澤 要,田中 榮司,上田 和彦,角谷 眞澄,清澤 研道
肝臓 = ACTA HEPATOLOGICA JAPONICA, 48(11), 553-558, 2007年11月25日

A lean man with nonalcoholic fatty liver disease
Tanaka, Naoki; Yazaki, Masahide; Kobayashi, Keiko
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 5(3), XXXII-XXXII, 2007年03月

Efficacy and safety of 6-month iron reduction therapy in patients with hepatitis C virus-related cirrhosis: a pilot study
Tanaka, Naoki; Horiuchi, Akira; Yamaura, Takahiro; Komatsu, Michiharu; Tanaka, Eiji; Kiyosawa, Kendo
JOURNAL OF GASTROENTEROLOGY, 42(1), 49-55, 2007年01月

Useful parameters for distinguishing nonalcoholic steatohepatitis with mild steatosis from cryptogenic chronic hepatitis in the Japanese population
Tanaka, Naoki; Tanaka, Eiji; Sheena, Yo;Komatsu, Michiharu; Okiyama, Wataru; Misawa, Noriko; Muto, Hidetomo; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Horiuchi, Akira; Kiyosawa, Kendo
LIVER INTERNATIONAL, 26(8), 956-963, 2006年10月

Peroxisome proliferator-activated receptor alpha-independent peroxisome proliferation
Zhang, Xiuguo; Tanaka, Naoki; Nakajuna, Takero; Kamijo, Yuji; Gonzalez, Frank J.; Aoyama, Toshifumi
Biochemical and biophysical research communications, 346(4), 1307-1311, 2006年08月11日

Laparoscopic findings in patients with nonalcoholic steatohepatitis
Tanaka, N; Ichijo, T; Okiyama, W; Mutou, H; Misawa, N; Matsumoto, A; Yoshizawa, K; Tanaka, E; Kiyosawa, K
LIVER INTERNATIONAL, 26(1), 32-38, 2006年02月

Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage
Nakajima, T; Kamijo, Y; Tanaka, N; Sugiyama, E; Tanaka, E; Kiyosawa, K; Fukushima, Y; Peters, JM; Gonzalez, FJ; Aoyama, T
Hepatology, 40(4), 972-980, 2004年10月

Phlebotomy: a promising treatment for chronic hepatitis C
Tanaka, N; Kiyosawa, K
JOURNAL OF GASTROENTEROLOGY, 39(6), 601-603, 2004年06月

Ribavirin-induced pure red-cell aplasia during treatment of chronic hepatitis C.
Tanaka, N; Ishida, F; Tanaka, E
NEW ENGLAND JOURNAL OF MEDICINE, 350(12), 1264-1265, 2004年03月18日

In vivo stabilization of nuclear retinoid X receptor alpha in the presence of peroxisome proliferator-activated receptor alpha
Tanaka,N; Hora, K; Makishima, H; Kamijo, Y; Kiyosawa, K; Gonzalez, FJ; Aoyama, T
FEBS Letters, 543(1-3), 120-124, 2003年05月22日

Development of hepatocellular carcinoma after longterm sustained complete response to interferon therapy: what is the mechanism?
Tanaka, N; Kiyosawa, K
JOURNAL OF GASTROENTEROLOGY, 38(4), 417-419, 2003年04月

非アルコール性脂肪性肝炎
田中 直樹,清澤 研道
肝臓, 43(12), 539-549, 2002年12月25日

非アルコール性脂肪肝炎の発症機構とPPAR
田中 直樹,青山 俊文
日本消化器病學會雜誌 = The Japanese journal of gastro-enterology, 99(6), 563-569, 2002年06月05日

トピックス 4.Peroxisome proliferator-activated receptor(PPAR)
田中 直樹,青山 俊文
日本内科学会雑誌, 90(10), 2033-2039, 2001年10月10日

Initiation of enzyme replacement therapy for an adult patient with asymptomatic type 1 Gaucher's disease
Tanaka, N; Saito, H; Ito, T; Momose, K; Ishida, F; Hora, K; Kiyosawa, K; Ida, H
INTERNAL MEDICINE, 40(8), 716-721, 2001年08月

Back pain out of the blue in a haemodialysis patient
Tanaka, N; Kasahara, H; Yoshie, T; Hora, K; Kiyosawa, K
NEPHROLOGY DIALYSIS TRANSPLANTATION, 14(7), 1792-1794, 1999年07月

人間機能・形態学概論
信州大学

人間機能・形態学概論
信州大学

人間機能・形態学概論
信州大学

人間機能・形態学概論
信州大学

人間機能・形態学概論
信州大学

疾患予防医科学
信州大学

生化学
信州大学

人間機能・形態学概論
信州大学

疾患予防医科学
信州大学

生化学
信州大学

人間機能・形態学概論
信州大学

疾患予防医化学概論
信州大学

生化学
信州大学

生化学
信州大学

生化学
信州大学

生化学
信州大学

生化学
信州大学

生化学
信州大学

日本糖尿病学会

日本医学教育学会

日本消化器病学会

日本肝臓学会

日本病態栄養学会

日本生化学会

日本内科学会

食事中トランス脂肪酸による肝発癌促進機能の解明と予防法の開発
科学研究費補助金, 基盤研究（Ｃ）
2019年 - 2021年

生体異物代謝を機軸とした非アルコール性脂肪肝炎発症機構の解明
科学研究費補助金, 基盤研究（Ｃ）
2016年 - 2018年

PPARα 活性化抑制を標的としたＣ型肝炎関連肝癌の予防法の開発
科学研究費補助金, 若手研究（Ｂ）
2009年 - 2010年

PPARα ノックアウトマウスを用いたアルコール性肝障害の病態解析と治療法の開発
科学研究費補助金, 若手研究（Ｂ）
2007年 - 2008年

消化管および肝臓におけるアルコール依存的炎症性障害の分子機構の解明と予防法の開発
科学研究費補助金, 基盤研究（Ｃ）
2007年 - 2008年

共同研究, 米国国立衛生研究所　癌研究所　代謝部門
2004年

肥満や脂肪肝を予防する機能性食品

脂肪肝・脂肪肝炎に起因する肝発癌機構の解明と治療法の開発

非アルコール性脂肪肝炎の病態解析と治療法の開発

国際医学研究・教育

栄養素と消化器病

脂質代謝と核内受容体

肝臓と脂肪細胞の相互関係

メタボロミクス

本当は怖～い脂肪肝
信毎メディアガーデン, 2018年07月29日

食生活と生活習慣病
講師
信州ソルガム高度活用研究プロジェクトキックオフシンポジウム, 信州大学工学部, 2017年06月20日

食生活と生活習慣病
信州大学工学部, 2017年06月20日

内臓肥満と糖尿病・高血圧-健診データのみかた–
平成27年度生坂村ヘルスアップ教室, 生坂村, 2017年01月22日

本当はこわい脂肪肝～小児から大人まで～
安曇野市, 2016年07月03日

NAFLD/NASHの病態・診断と今後の展望
講師
第34回日本消化器病学会甲信越支部教育講演会, 信州大学, 2015年

健康ばんざい　肝疾患
長野放送, 2021年04月24日

こんにちはドクター『本当にこわい脂肪肝』
SBCラジオ, 2017年03月26日, テレビ・ラジオ番組

奥様はホームドクター『本当はこわい脂肪肝』
テレビ信州, 2017年03月06日, テレビ・ラジオ番組

医師免許
1995年05月

2020年, 1, 1, 5, 4, 2, 2

2019年, 2, 2, 5, 4, 1, 1

2006年, 1, 1, 1, 1

2021年, 5, 4, 0, 0

2010年, 5, 1, 5, 1

2009年, 1, 0, 1, 0

2008年, 2, 0, 2, 0

2012年, 1, 0, 1, 0

2014年, 2, 0, 2, 0

2018年, 1, 1

2016年, 2, 2

2019年, 2, 0

2017年, 2, 2

2020年, 1, 0, 2人入学希望、COVID-19 のため1人は入学後休学、もう一人は入試を受験できず。

2017年
信州大学医学部顕彰　短期留学, 米国国立衛生研究所

2016年
国際交流, ドイツ　ドレスデン工科大学

2016年
国際交流, インドネシア

2016年, 医学部国際交流推進室, 副室長