植村 健 (ウエムラ タケシ)
学術研究院（総合人間科学系（基盤研究支援センター））
基盤研究支援センター
教授
研究者情報
研究キーワード
- 中枢神経, 脳神経回路網形成, 神経発達障害, シナプス
電話番号
- 0263-37-3108
メールアドレス
- tuemura★shinshu-u.ac.jp
経歴
研究活動情報
論文
- Development of phosphate-treated PEEK implants with high osseointegration
Yu Usuda, Takumi Okihara, Shigeaki Moriyama, Takeshi Uemura, Takayuki Kamanaka, Aoi William Omi, Naoto Saito, Jun Takahashi, Kaoru Aoki, Naoyuki Nishimura
Materials Today Communications, 38, 107717, 2024年03月
- Biocompatibility Evaluation of Carbon Nanohorns in Bone Tissues
Ueda, K; Ma, C; Izumiya, M; Kuroda, C; Ishida, H; Uemura, T; Saito, N; Aoki, K; Haniu, H
Nanomaterials, 2023年01月
- Neurexins in serotonergic neurons regulate neuronal survival, serotonin transmission, and complex mouse behaviors
Cheung, A; Konno, K; Imamura, Y; Matsui, A; Abe, M; Sakimura, K; Sasaoka, T; Uemura, T; Watanabe, M; Futai, K; Brose, N
Elife, 2023年01月
筆頭著者, 責任著者 - Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins
Uemura, Takeshi; Suzuki-Kouyama, Emi; Kawase, Shiori; Kurihara, Taiga; Yasumura, Misato; Yoshida, Tomoyuki; Fukai, Shuya; Yamazaki, Maya; Fei, Peng; Abe, Manabu; Watanabe, Masahiko; Sakimura, Kenji; Mishina, Masayoshi; Tabuchi, Katsuhiko;
CELL REPORTS, 39(1), 110624, 2022年 - IQSEC3 Deletion Impairs Fear Memory Through Upregulation of Ribosomal S6K1 Signaling in the Hippocampus
Kim, Dongwook; Jung, Hyeji; Shirai, Yoshinori; Kim, Hyeonho; Kim, Jinhu; Lim, Dongseok; Mori, Takuma; Lee, Hyojeong; Park, Dongseok; Kim, Hee Young; Guo, Qi; Pang, Bo; Qiu, Wen; Cao, Xueshan; Kouyama-Suzuki, Emi; Uemura, Takeshi; Kasem, Enas; Fu, Yu; Kim, Seungjoon; Tokunaga, Akinori; Yoshizawa, Takahiro; Suzuki, Tatsuo; Sakagami, Hiroyuki; Lee, Kea Joo; Ko, Jaewon; Tabuchi, Katsuhiko; Um, Ji Won;
BIOLOGICAL PSYCHIATRY, 91(9), 821-831, 2022年 - Future Prospects for Clinical Applications of Nanocarbons Focusing on Carbon Nanotubes
Saito, Naoto; Haniu, Hisao; Aoki, Kaoru; Nishimura, Naoyuki; Uemura, Takeshi;
ADVANCED SCIENCE, 2201214, 2022年
最終著者 - Evaluation of MC3T3-E1 Cell Osteogenesis in Different Cell Culture Media
Izumiya, Makoto; Haniu, Miyu; Ueda, Katsuya; Ishida, Haruka; Ma, Chuang; Ideta, Hirokazu; Sobajima, Atsushi; Ueshiba, Koki; Uemura, Takeshi; Saito, Naoto; Haniu, Hisao;
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(14), 2021年07月 - Abundant oleoyl-lysophosphatidylethanolamine in brain stimulates neurite outgrowth and protects against glutamate toxicity in cultured cortical neurons
Hisano, Kazutoshi; Yoshida, Hironori; Kawase, Shiori; Mimura, Tetsuhiko; Yoshida, Hironori;Haniu, Hisao; Tsukahara, Tamotsu; Kurihara, Taiga; Matsuda, Yoshikazu; Saito, Naoto; Uemura, Takeshi;
The Journal of Biochemistry, Apr 5;mvab046., 2021年
最終著者, 責任著者 - Structurally different lysophosphatidylethanolamine species stimulate neurite outgrowth in cultured cortical neurons via distinct G-protein-coupled receptors and signaling cascades
Hisano, Kazutoshi; Kawase, Shiori; Mimura, Tetsuhiko; Yoshida, Hironori; Yamada, Hiroki; Haniu, Hisao; Tsukahara, Tamotsu; Kurihara, Taiga; Matsuda, Yoshikazu; Saito, Naoto; Uemura, Takeshi;
Biochemical and biophysical research communications, 534, 179-185, 2021年
最終著者, 責任著者 - Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice
Yoshida, Tomoyuki; Yamagata, Atsushi; Imai, Ayako; Kim, Juhyon; Izumi, Hironori; Nakashima, Shogo; Shiroshima, Tomoko; Maeda, Asami; Iwasawa-Okamoto, Shiho; Azechi, Kenji; Osaka, Fumina; Saitoh, Takashi; Maenaka, Katsumi; Shimada, Takashi; Fukata, Yuko; Fukata, Masaki; Matsumoto, Jumpei; Nishijo, Hisao; Takao, Keizo; Tanaka, Shinji; Okabe, Shigeo; Tabuchi, Katsuhiko; Uemura, Takeshi; Mishina, Masayoshi; Mori, Hisashi; Fukai, Shuya;
NATURE COMMUNICATIONS, 12(1), 1848, 2021年 - Therapeutic Potential of Porcine Liver Decomposition Product: New Insights and Perspectives for Microglia-Mediated Neuroinflammation in Neurodegenerative Diseases
Tsukahara, Tamotsu; Haniu, Hisao; Uemura, Takeshi; Matsuda, Yoshikazu;
BIOMEDICINES, 8(11), 2020年11月 - Oral administration of porcine liver decomposition product for 4 weeks enhances visual memory and delayed recall in healthy adults over 40 years of age: A randomized, double-blind, placebo-controlled study
Matsuda, Yoshikazu; Haniu, Hisao; Tsukahara, Tamotsu; Uemura, Takeshi; Inoue, Toshio; Sako, Ken-ichi; Kojima, Jun; Mori, Tatsuro; Sato, Kazusaburou;
EXPERIMENTAL GERONTOLOGY, 141, 2020年11月 - Cellular Responses of Human Lymphatic Endothelial Cells to Carbon Nanomaterials
Sano, Mahoko; Izumiya, Makoto; Haniu, Hisao; Ueda, Katsuya; Konishi, Kosuke; Ishida, Haruka; Kuroda, Chika; Uemura, Takeshi; Aoki, Kaoru; Matsuda, Yoshikazu; Saito, Naoto;
Nanomaterials, 10(7), 2020年07月 - Porcine liver decomposition product-derived lysophospholipids promote microglial activation in vitro
Tsukahara Tamotsu;Haniu Hisao;Uemura Takeshi;Matsuda Yoshikazu
SCIENTIFIC REPORTS, 10(1), 2020年02月28日
- Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells
Yoshida, Kazushige; Okamoto, Masanori; Sasaki, Jun; Kuroda, Chika; Ishida, Haruka; Ueda, Katsuya; Ideta, Hirokazu; Kamanaka, Takayuki; Sobajima, Atsushi; Takizawa, Takashi; Tanaka, Manabu; Aoki, Kaoru; Uemura, Takeshi; Kato, Hiroyuki; Haniu, Hisao; Saito, Naoto;
BMC CANCER, 20(1), 2020年 - DNA repair protein RAD51 enhances the CRISPR/Cas9-mediated knock-in efficiency in brain neurons
Kurihara, Taiga; Kouyama-Suzuki, Emi; Satoga, Michiru; Li, Xue; Badawi, Moataz; Thiha; Baig, Deeba Noreen; Yanagawa, Toru; Uemura, Takeshi; Mori, Takuma; Tabuchi, Katsuhiko;
Biochemical and biophysical research communications, 524(3), 621-628, 2020年 - Specific Neuroligin3-alpha Neurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus
Uchigashima, Motokazu; Konno, Kohtarou; Demchak, Emily; Cheung, Amy; Watanabe, Takuya; Keener, David G.; Abe, Manabu; Le, Timmy; Sakimura, Kenji; Sasaoka, Toshikuni; Uemura, Takeshi; Kawasawa, Yuka Imamura; Watanabe, Masahiko; Futai, Kensuke;
Elife, 9, 2020年 - Carbon fibers for treatment of cancer metastasis in bone
Kamanaka, Takayuki; Haniu, Hisao; Tanaka, Manabu; Takizawa, Takashi; Aoki, Kaoru; Okamoto, Masanori; Sobajima, Atsushi; Yoshida, Kazushige; Ideta, Hirokazu; Mimura, Tetsuhiko; Ishida, Haruka; Ueda, Katsuya; Uemura, Takeshi; Kim, Jin Hee; Kim, Yoong Ahm; Kato, Hiroyuki; Saito, Naoto;
RSC Advances, 10(55), 33071-33079, 2020年 - Deficiency of calcium/calmodulin-dependent serine protein kinase disrupts the excitatory-inhibitory balance of synapses by downregulating GluN2B (vol 24, pg 1079, 2019)
Mori, Takuma; Kasem, Enas A.; Suzuki-Kouyama, Emi; Cao, Xueshan; Li, Xue; Kurihara, Taiga; Uemura, Takeshi; Yanagawa, Toru; Tabuchi, Katsuhiko;
MOLECULAR PSYCHIATRY, 24(7), 1093-1093, 2019年07月 - Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T cell activation markers
Yoshida, Kazushige; Okamoto, Masanori; Sasaki, Jun; Kuroda, Chika; Ishida, Haruka; Ueda, Katsuya; Okano, Satomi; Ideta, Hirokazu; Kamanaka, Takayuki; Sobajima, Atsushi; Takizawa, Takashi; Kito, Munehisa; Aoki, Kaoru; Uemura, Takeshi; Haniu, Hisao; Kato, Hiroyuki; Saito, Naoto;
OncoTargets and Therapy, 12, 2513-2518, 2019年 - Structural basis of trans-synaptic interactions between PTPδ and SALMs for inducing synapse formation
Goto-Ito S, Yamagata A, Sato Y, Uemura T, Shiroshima T, Maeda A, Imai A, Mori H, Yoshida T, Fukai
NATURE COMMUNICATIONS, 9, 269, 2018年, 査読有り
最終著者, 責任著者 - MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells
Kawabata Galbraith K, Fujishima K, Mizuno H, Lee SJ, Uemura T, Sakimura K, Mishina M, Watanabe N, Kengaku M
Cell Rep, 24, 95-106, 2018年, 査読有り - Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction
Yamagata, Atsushi; Goto-Ito, Sakurako; Sato, Yusuke; Shiroshima, Tomoko; Maeda, Asami; Watanabe, Masahiko; Saitoh, Takashi; Maenaka, Katsumi; Terada, Tohru; Yoshida, Tomoyuki; Uemura, Takeshi; Fukai, Shuya;
NATURE COMMUNICATIONS, 9, 2018年
責任著者 - In situ screening for postsynaptic cell adhesion molecules during synapse formation
Uemura T, Shiroshima T, Maeda A, Yasumura M, Shimada T, Fukata Y, Fukata M, Yoshida T
JOURNAL OF BIOCHEMISTRY, 162, 295-302, 2017年, 査読有り
筆頭著者, 責任著者 - Fluorescent protein tagging of endogenous protein in brain neurons using CRISPR/Cas9-mediated knock-in and in utero electroporation techniques
Uemura, Takeshi; Mori, Takuma; Kurihara, Taiga; Kawase, Shiori; Koike, Rie; Satoga, Michiru; Cao, Xueshan; Li, Xue; Yanagawa, Toru; Sakurai, Takayuki; Shindo, Takayuki; Tabuchi, Katsuhiko;
SCIENTIFIC REPORTS, 6, 2016年
筆頭著者, 責任著者 - Mechanisms of splicing-dependent trans-synaptic adhesion by PTP delta-IL1RAPL1/IL-1RAcP for synaptic differentiation
Yamagata, Atsushi; Yoshida, Tomoyuki; Sato, Yusuke; Goto-Ito, Sakurako; Uemura, Takeshi; Maeda, Asami; Shiroshima, Tomoko; Iwasawa-Okamoto, Shiho; Mori, Hisashi; Mishina, Masayoshi; Fukai, Shuya;
NATURE COMMUNICATIONS, 6, 2015年04月 - Structure of Slitrk2-PTP delta complex reveals mechanisms for splicing-dependent trans-synaptic adhesion
Yamagata, Atsushi; Sato, Yusuke; Goto-Ito, Sakurako; Uemura, Takeshi; Maeda, Asami; Shiroshima, Tomoko; Yoshida, Tomoyuki; Fukai, Shuya;
SCIENTIFIC REPORTS, 5, 2015年 - Electron microscopy of primary cell cultures in solution and correlative optical microscopy using ASEM
Hirano, Kazumi; Kinoshita, Takaaki; Uemura, Takeshi; Motohashi, Hozumi; Watanabe, Yohei; Ebihara, Tatsuhiko; Nishiyama, Hidetoshi; Sato, Mari; Suga, Mitsuo; Maruyama, Yuusuke; Tsuji, Noriko M.; Yamamoto, Masayuki; Nishihara, Shoko; Sato, Chikara;
ULTRAMICROSCOPY, 143, 52-66, 2014年08月 - Striatal dopamine D1 receptor is essential for contextual fear conditioning
Ikegami M, Uemura T, Kishioka A, Sakimura K, Mishina M
SCIENTIFIC REPORTS, 4, 3976, 2014年 - IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours
Yasumura, Misato; Yoshida, Tomoyuki; Yamazaki, Maya; Abe, Manabu; Natsume, Rie; Kanno, Kouta; Uemura, Takeshi; Takao, Keizo; Sakimura, Kenji; Kikusui, Takefumi; Miyakawa, Tsuyoshi; Mishina, Masayoshi;
SCIENTIFIC REPORTS, 4, 2014年 - Striatal dopamine D1 receptor is essential for contextual fear conditioning
Ikegami, Masaru; Uemura, Takeshi; Kishioka, Ayumi; Sakimura, Kenji; Mishina, Masayoshi;
SCIENTIFIC REPORTS, 4, 2014年 - Synapse formation in the brain
Mishina M, Yoshida T, Yasumura M, Uemura T
Cortical Development, 282, 229－248, 2013年 - Consolidation of auditory fear memories formed by weak unconditioned stimuli requires NMDA receptor activation and de novo protein synthesis in the striatum
Kishioka A, Uemura T, Fukushima F, Mishina M
Mol. Brain, 6, 17, 2013年 - Molecular mechanism of parallel fiber-Purkinje cell synapse formation.
Masayoshi Mishina, Takeshi Uemura, Misato Yasumura and Tomoyuki Yoshida
Frontiers in Neural Circuits, 6(90), doi: 10.3389/fncir.2012.00090, 2012年, 査読有り - GluRδ2 Assembles Four Neurexins into Trans-Synaptic Triad to Trigger Synapse Formation
Lee SJ, Uemura T, Yoshida T, Mishina M
J Neurosci, 32(13), 4688-4701, 2012年 - Interleukin-1 Receptor Accessory Protein organizes neuronal synaptogenesis as a cell adhesion molecule
Yoshida T, Shiroshima T, Lee SJ, Yasumura M, Uemura T, Chen X, Iwakura Y, Mishina M
J Neurosci, 32(8), 2588-2600, 2012年 - Glutamate receptor δ1 induces preferentially inhibitory presynaptic differentiation of corticalneurons by interacting with neurexins through cerebellin precursor protein subtypes
Yasumura M, Yoshida T, Lee SJ, Uemura T, Joo JY, Mishina M
J Neurochem, 121(5), 705-716, 2012年 - IL-1 Receptor Accessory Protein-Like 1 Associated with Mental Retardation and Autism Mediates Synapse Formation by Trans-Synaptic Interaction with Protein Tyrosine Phosphatase δ
Yoshida T, Yasumura M, Uemura T, Lee SJ, Ra M, Taguchi R, Iwakura Y, Mishina M
J Neurosci, 31(88), 13485-13499, 2011年 - Differential Interactions of Cerebellin Precursor Protein (Cbln) Subtypes and Neurexin Variants for Synapse Formation of Cortical Neurons
Joo JY, Lee SJ, Uemura T, Yoshida T, Yasumura M, Watanabe M, Mishina M
Biochem Biophys Res Commun, 406(4), 627-632, 2011年 - Trans-synaptic interaction of GluRδ2 and neurexin through Cbln1 mediates synapse formation in the cerebellum
Uemura T, Lee SJ, Yasumura M, Takeuchi T, Yoshida T, Ra M, Taguchi R, Sakimura K, Mishina M
Cell, 141(6), 1068-1079, 2010年 - The amino-terminal domain of glutamate receptor δ2 triggers presynaptic differentiation
Uemura T, Mishina M
Biochem Biophys Res Commun, 377(4), 1315-1319, 2008年 - Role of the internal Shank-binding segment of glutamate receptor δ2 in synaptic localization and cerebellar functions
Yasumura M, Uemura T, Yamasaki M, Sakimura K, Watanabe M, Mishina
Neurosci Lett, 433(2), 146-151, 2008年 - Regulation of long-term depression and climbing fiber territory by glutamate receptor δ2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells
Uemura T, Kakizawa S, Yamasaki M, Sakimura K, WatanabeM, Iino M, Mishina M
J Neurosci, 27(44), 12096-12108, 2007年 - Direct interaction of GluRδ2 with Shank scaffold proteins in cerebellar Purkinje cells
Uemura T, Mori H, Mishina M
Mol Cell Neurosci, 26(2), 330-341, 2004年 - Molecular visualization of immunoglobulin switch region RNA/DNA complex byatomic force microscope
Mizuta R, Iwai K, Shigeno M, Mizuta M, Uemura T, Ushiki, T, Kitamura D
J Biol Chem, 278(7), 4431-4434, 2003年 - Isolation and Characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain
Uemura T, Mori H, Mishina M
Biochem Biophys Res Commun, 296(2), 492-496, 2002年
書籍等出版物
