A novel ELISA system for measuring modified LDL-adiponectin complex.
Sasaoka, M., Kakino, A., Villalobos-Labra, R., Yamashita, Y., Spaans, F., Joshita, S., Hosoda, H., Uehara, T., Chen, C.H., Davidge, S.T. and Sawamura, T.
J Atheroscler Thromb, 2025年
Oxidized low-density lipoprotein potentiates angiotensin II-induced Gq activation through the AT1-LOX1 receptor complex: Implications for renal dysfunction.
2. Ihara, J., Huang, Y., Takami, Y., Nozato, Y., Takahashi, T., Kakino, A., Wang, C., Wang, Z., Guo, Y., Liu, W., Yin, N., Ohara, R., Fujimoto, T., Yoshida, S., Hongyo, K., Koriyama, H., Akasaka, H., Takeshita, H., Sakai, S., Inoue, K., Isaka, Y., Rakugi, H., Sawamura, T. and Yamamoto, K.
eLife, 13, RP98766, 2025年
Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection in cynomolgus macaque.
Nguyen, C. T., Nakayama, M., Ishigaki, H., Kitagawa, Y., Kakino, A., Ohno, M., Shingai, M., Suzuki, Y., Sawamura, T., Kida, H. and Ito, Y.
Virology, 594, 110052, 2024年
LOX-1 deficiency increases ruptured abdominal aortic aneurysm via thinning of adventitial collagen.
Takahashi, K., Aono, J., Nakao, Y., Hamaguchi, M., Suehiro, C., Kurata, M., Sakaue, T., Kakino, A., Sawamura, T., Inoue, K., Ikeda, S., Suzuki, J. and Yamaguchi, O.
Hypertens Res, 46, 63-74, 2023年
NanoSPECT imaging reveals the uptake of 123I-labeled oxidized low-density lipoprotein in the brown adipose tissue of mice via CD36.
Hosomi, K., Kawashima, H., Nakano, A., Kakino, A., Okamatsu-Ogura, Y., Yamashita, Y., Sasaoka, M., Masuda, D., Yamashita, S., Chen, C.H., Yuzuriha, S., Hosoda, H., Iida, H. and Sawamura, T.
Cardiovasc Res, 119, 1008-1020, 2023年
Serum modified high-density lipoprotein and risk of atherosclerotic cardiovascular disease in a Japanese community-based nested case-control study.
Sata, M., Kakino, A. (co-first author), Hirata, A., Iida, M., Usami, Y., Harada, S., Fujita, Y., Kohsaka, S., Izawa, Y., Sawano, M., Oki, K., Sugiyama, D., Takahashi, S., Takebayashi, T., Sawamura, T. and Okamura, T.
Eur J Prev Cardiol, 29, e193-e195, 2022年
Adiponectin forms a complex with atherogenic LDL and inhibits its downstream effects.
Kakino, A., Fujita, Y., Ke, L.Y., Chan, H.C., Tsai, M.H., Dai, C.Y., Chen, C.H. and Sawamura, T.
J Lipid Res, 62, 100001, 2021年
Abnormal blood coagulation and kidney damage in aged hamsters infected with severe acute respiratory syndrome coronavirus 2.
Ohno, M., Sasaki, M., Orba, Y., Sekiya, T., Masum, M.A., Ichii, O., Sawamura, T., Kakino, A., Suzuki, Y., Kida, H., Sawa, H. and Shingai, M.
Viruses, 13, 2137, 2021年
Critical role of oxidized LDL receptor-1 in intravascular thrombosis in a severe influenza mouse model.
Ohno, M., Kakino, A., Sekiya, T., Nomura, N., Shingai, M., Sawamura, T. and Kida, H.
Sci Rep, 11, 15675, 2021年
Quantitative and qualitative lipid improvement with chronic hepatitis C virus eradication using with direct-acting antivirals.
Joshita, S., Yamashita, Y., Okamoto, T., Usami, Y., Sugiura, A., Yamazaki, T., Kakino, A., Ota, M., Sawamura, T. and Umemura, T.
Hepatol Res, 51, 758-766, 2021年
RAGE ligands stimulate angiotensin II type I receptor (AT1) via RAGE/AT1 complex on the cell membrane.
Yokoyama, S., Kawai, T., Yamamoto, K., Yibin, H., Yamamoto, H., Kakino, A., Takeshita, H., Nozato, Y., Fujimoto, T., Hongyo, K., Takahashi, T., Nakagami, F., Akasaka, H., Takami, Y., Takeya, Y., Sugimoto, K., Sawamura, T. and Rakugi, H.
Sci Rep, 11, 5759, 2021年
The endocytosis of oxidized LDL via the activation of the angiotensin II type 1 receptor
Takahashi, T., Huang, Y., Yamamoto, K., Hamano, G., Kakino, A., Kang, F., Imaizumi, Y., Takeshita, H., Nozato, Y., Nozato, S., Yokoyama, S., Nagasawa, M., Kawai, T., Takeda, T., Fujimoto, T., Hongyo, K., Nakagami, F., Akasaka, H., Takami, Y., Takeya, Y., Sugimoto, K., Gaisano, H.Y., Sawamura, T. and Rakugi, H.
ISCIENCE, 24, 102076, 2021年
The relationship between serum levels of LOX-1 ligand containing ApoAI as a novel marker of dysfunctional HDL and coronary artery calcification in middle-aged Japanese men.
Hirata, A., Kakino, A., Okamura, T., Usami, Y., Fujita, Y., Kadota, A., Fujiyoshi, A., Hisamatsu, T., Kondo, K., Segawa, H., Sawamura, T., Miura, K. and Ueshima, H.
Atherosclerosis, 313, 20-25, 2020年
LOX-1 deletion has protective effects on stroke in the genetic background of stroke-prone spontaneously hypertensive rat.
Liang, Y.Q., Kakino, A. (co-first author), Matsuzaka, Y., Mashimo, T., Isono, M., Akamatsu, T., Shimizu-Furusawa, H., Tajima, M., Kaneko, T., Li, L., Takeuchi, F., Sawamura, T. and Kato, N.
Stroke, 51, 1835-1843, 2020年
LDL uptake-dependent phosphatidylethanolamine translocation to the cell surface promotes fusion of osteoclast-like cells.
Kitano, V.J.F., Ohyama, Y., Hayashida, C., Ito, J., Okayasu, M., Sato, T., Ogasawara, T., Tsujita, M., Kakino, A., Shimada, J., Sawamura, T. and Hakeda, Y.
J Cell Sci, 133, jcs243840, 2020年
Detection of a high ratio of soluble to membrane-bound LOX-1 in aspirated coronary thrombi from patients with ST-segment-elevation myocardial infarction.
Lee, A.S., Wang, Y.C., Chang, S.S., Lo, P.H., Chang, C.M., Lu, J., Burns, A.R., Chen, C.H., Kakino, A., Sawamura, T. and Chang, K.C.
J Am Heart Assoc, 9, e014008, 2020年
A novel cell-free, non-fluorescent method to measure LOX-1-binding activity corresponding to the functional activity of HDL.
Kakino, A., Usami, Y., Horiuchi, S., Fujita, Y., Kotani, K., Chen, C.H., Okamura, T. and Sawamura, T.
J Atheroscler Thromb, 26, 947-958, 2019年
123I-labeled oxLDL is widely distributed throughout the whole body in mice.
Nakano, A., Kawashima, H., Miyake, Y., Zeniya, T., Yamamoto, A., Koshino, K., Temma, T., Fukuda, T., Fujita, Y., Kakino, A., Kanaya, S., Sawamura, T. and Iida, H.
Nucl Med Mol Imaging, 52, 144-153, 2018年
LOX-1 in ischemic stroke.
Sawamura, T., Fujita, Y., Horiuchi, S., Kakino, A.
J Atheroscler Thromb, 24, 566-568, 2017年
L5: an LDL fraction in which pathogenic activity of LDL is concentrated.
Sawamura, T., Fujita, Y., Horiuchi, S., Kakino, A.
Trends Cardiovasc Med, 27, 247-248, 2017年
Developmental endothelial locus-1 (Del-1) inhibits oxidized low-density lipoprotein activity by direct binding, and its overexpression attenuates atherogenesis in mice.
Kakino, A., Fujita, Y., Nakano, A., Horiuchi, S. and Sawamura, T.
Circ J, 80, 2541-2549, 2016年
High levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 in acute stroke: an age- and sex-matched cross-sectional study.
Yokota, C., Sawamura, T., Watanabe, M., Kokubo, Y., Fujita, Y., Kakino, A., Nakai, M., Toyoda, K., Miyamoto, Y. and Minematsu, K.
J Atheroscler Thromb, 23, 1222-1226, 2016年
Deletion of LOX-1 protects against heart failure induced by doxorubicin.
Yokoyama, C., Aoyama, T., Ido, T., Kakino, A., Shiraki, T., Tanaka, T., Nishigaki, K., Hasegawa, A., Fujita, Y., Sawamura, T. and Minatoguchi, S.
PLOS ONE, 11, e0154994, 2016年
Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor.
Yamamoto, K., Kakino, A. (co-first author), Takeshita, H., Hayashi, N., Li, L., Nakano, A., Hanasaki-Yamamoto, H., Fujita, Y., Imaizumi, Y., Toyama-Yokoyama, S., Nakama, C., Kawai, T., Takeda, M., Hongyo, K., Oguro, R., Maekawa, Y., Itoh, N., Takami, Y., Onishi, M., Takeya, Y., Sugimoto, K., Kamide, K., Nakagami, H., Ohishi, M., Kurtz, T.W., Sawamura, T. and Rakugi, H.
FASEB J, 29, 3342-3356, 2015年
Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state.
Nakayachi, M., Ito, J., Hayashida, C., Ohyama, Y., Kakino, A., Okayasu, M., Sato, T., Ogasawara, T., Kaneda, T., Suda, N., Sawamura, T. and Hakeda, Y.
BONE, 75, 170-182, 2015年
LOX-1 ligands containing apolipoprotein B and carotid intima-media thickness in middle-aged community-dwelling US Caucasian and Japanese men.
Okamura, T., Sekikawa, A., Sawamura, T., Kadowaki, T., Barinas-Mitchell, E., Mackey, R.H., Kadota, A., Evans, R.W., Edmundowicz, D., Higashiyama, A., Nakamura, Y., Abbott, R.D., Miura, K., Fujiyoshi, A., Fujita, Y., Murakami, Y., Miyamatsu, N., Kakino, A., Maegawa, H., Murata, K., Horie, M., Mitsunami, K., Kashiwagi, A., Kuller, L.H., Ueshima, H. and Group, E.J.S.
Atherosclerosis, 229, 240-245, 2013年
Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis.
Ishikawa, M., Ito, H., Akiyoshi, M., Kume, N., Yoshitomi, H., Mitsuoka, H., Tanida, S., Murata, K., Shibuya, H., Kasahara, T., Kakino, A., Fujita, Y., Sawamura, T., Yasuda, T. and Nakamura, T.
Arthritis Rheum, 64, 1024-1034, 2012年
Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation.
Fujita, Y., Yamaguchi, S., Kakino, A., Iwamoto, S., Yoshimoto, R. and Sawamura, T.
Clin Chem, 57, 1398-1405, 2011年
An alternative protein standard to measure activity of LOX-1 ligand containing apoB (LAB) - utilization of anti-LOX-1 single- chain antibody fused to apoB fragment.
Iwamoto, S., Fujita, Y., Kakino, A., Yanagida, K., Matsuda, H., Yoshimoto, R. and Sawamura, T.
J Atheroscler Thromb, 18, 818-828, 2011年
Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox.
Nishizuka, T., Fujita, Y., Sato, Y., Nakano, A., Kakino, A., Ohshima, S., Kanda, T., Yoshimoto, R. and Sawamura, T.
Proc Jpn Acad Ser B Phys Biol Sci, 87, 104-113, 2011年
Pitavastatin reduces lectin-like oxidized low-density lipoprotein receptor-1 ligands in hypercholesterolemic humans.
Matsumoto, T., Fujita, M., Sawamura, T., Kakino, A., Sato, Y., Fujita, Y., Matsuda, H., Nakanishi, M., Uchida, K., Nakae, I., Kanda, H., Yoshida, A., Miwa, K., Hayashi, H., Mitsunami, K. and Horie, M.
Lipids, 45, 329-335, 2010年
LOX-1 mediates vascular lipid retention under hypertensive state.
Nakano, A., Inoue, N., Sato, Y., Nishimichi, N., Takikawa, K., Fujita, Y., Kakino, A., Otsui, K., Yamaguchi, S., Matsuda, H. and Sawamura, T.
J Hypertens, 28, 1273-1280, 2010年
LOX index, a novel predictive biochemical marker for coronary heart disease and stroke.
Inoue, N., Okamura, T., Kokubo, Y., Fujita, Y., Sato, Y., Nakanishi, M., Yanagida, K., Kakino, A., Iwamoto, S., Watanabe, M., Ogura, S., Otsui, K., Matsuda, H., Uchida, K., Yoshimoto, R. and Sawamura, T.
Clin Chem, 56, 550-558, 2010年
C-reactive protein uptake by macrophage cell line via class-A scavenger receptor.
Fujita, Y., Kakino, A., Harada-Shiba, M., Sato, Y., Otsui, K., Yoshimoto, R. and Sawamura, T.
Clin Chem, 56, 478-481, 2010年
LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells.
Sugimoto, K., Ishibashi, T., Sawamura, T., Inoue, N., Kamioka, M., Uekita, H., Ohkawara, H., Sakamoto, T., Sakamoto, N., Okamoto, Y., Takuwa, Y., Kakino, A., Fujita, Y., Tanaka, T., Teramoto, T., Maruyama, Y. and Takeishi, Y.
Cardiovasc Res, 84, 127-136, 2009年
Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects.
Fujita, Y., Kakino, A., Nishimichi, N., Yamaguchi, S., Sato, Y., Machida, S., Cominacini, L., Delneste, Y., Matsuda, H. and Sawamura, T.
Clin Chem, 55, 285-294, 2009年
DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics.
Ikura, T., Tashiro, S., Kakino, A., Shima, H., Jacob, N., Amunugama, R., Yoder, K., Izumi, S., Kuraoka, I., Tanaka, K., Kimura, H., Ikura, M., Nishikubo, S., Ito, T., Muto, A., Miyagawa, K., Takeda, S., Fishel, R., Igarashi, K. and Kamiya, K.
Mol Cell Biol, 27, 7028-7040, 2007年
