垣野 明美 (カキノ アケミ)
学術研究院（医学系）
先鋭領域融合研究群 バイオメディカル研究所
准教授
研究者情報
研究活動情報
受賞
- 2021年
高血圧関連疾患モデル学会 中尾賞 - 2019年
Journal of Atherosclerosis and Thrombosis 年間最優秀論文賞 - 2017年
アクテリオン アカデミアプライズ2017 - 2016年
68th AACC Annual Scientific Meeting Lipoproteins and Vascular Diseases Division Abstract Award - 2013年
第23回日本循環薬理学会 Young Investigator Award - 2013年
第17回日本心血管内分泌代謝学会 若手研究奨励賞 - 2013年
第86回日本生化学会 鈴木紘一メモリアル賞 - 2012年
第8回宮崎サイエンスキャンプ ヤング優秀賞 - 2012年
第85回日本薬理学会年会 優秀発表賞
論文
- Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection in cynomolgus macaque.
Nguyen, C. T., Nakayama, M., Ishigaki, H., Kitagawa, Y., Kakino, A., Ohno, M., Shingai, M., Suzuki, Y., Sawamura, T., Kida, H. and Ito, Y.
Virology, 594, 110052, 2024年 - LOX-1 deficiency increases ruptured abdominal aortic aneurysm via thinning of adventitial collagen.
Takahashi, K., Aono, J., Nakao, Y., Hamaguchi, M., Suehiro, C., Kurata, M., Sakaue, T., Kakino, A., Sawamura, T., Inoue, K., Ikeda, S., Suzuki, J. and Yamaguchi, O.
Hypertens Res, 46, 63-74, 2023年 - NanoSPECT imaging reveals the uptake of 123I-labeled oxidized low-density lipoprotein in the brown adipose tissue of mice via CD36.
Hosomi, K., Kawashima, H., Nakano, A., Kakino, A., Okamatsu-Ogura, Y., Yamashita, Y., Sasaoka, M., Masuda, D., Yamashita, S., Chen, C.H., Yuzuriha, S., Hosoda, H., Iida, H. and Sawamura, T.
Cardiovasc Res, 119, 1008-1020, 2023年 - Serum modified high-density lipoprotein and risk of atherosclerotic cardiovascular disease in a Japanese community-based nested case-control study.
Sata, M., Kakino, A. (co-first author), Hirata, A., Iida, M., Usami, Y., Harada, S., Fujita, Y., Kohsaka, S., Izawa, Y., Sawano, M., Oki, K., Sugiyama, D., Takahashi, S., Takebayashi, T., Sawamura, T. and Okamura, T.
Eur J Prev Cardiol, 29, e193-e195, 2022年 - Adiponectin forms a complex with atherogenic LDL and inhibits its downstream effects.
Kakino, A., Fujita, Y., Ke, L.Y., Chan, H.C., Tsai, M.H., Dai, C.Y., Chen, C.H. and Sawamura, T.
J Lipid Res, 62, 100001, 2021年 - Abnormal blood coagulation and kidney damage in aged hamsters infected with severe acute respiratory syndrome coronavirus 2.
Ohno, M., Sasaki, M., Orba, Y., Sekiya, T., Masum, M.A., Ichii, O., Sawamura, T., Kakino, A., Suzuki, Y., Kida, H., Sawa, H. and Shingai, M.
Viruses, 13, 2137, 2021年 - Critical role of oxidized LDL receptor-1 in intravascular thrombosis in a severe influenza mouse model.
Ohno, M., Kakino, A., Sekiya, T., Nomura, N., Shingai, M., Sawamura, T. and Kida, H.
Sci Rep, 11, 15675, 2021年 - Quantitative and qualitative lipid improvement with chronic hepatitis C virus eradication using with direct-acting antivirals.
Joshita, S., Yamashita, Y., Okamoto, T., Usami, Y., Sugiura, A., Yamazaki, T., Kakino, A., Ota, M., Sawamura, T. and Umemura, T.
Hepatol Res, 51, 758-766, 2021年 - RAGE ligands stimulate angiotensin II type I receptor (AT1) via RAGE/AT1 complex on the cell membrane.
Yokoyama, S., Kawai, T., Yamamoto, K., Yibin, H., Yamamoto, H., Kakino, A., Takeshita, H., Nozato, Y., Fujimoto, T., Hongyo, K., Takahashi, T., Nakagami, F., Akasaka, H., Takami, Y., Takeya, Y., Sugimoto, K., Sawamura, T. and Rakugi, H.
Sci Rep, 11, 5759, 2021年 - The endocytosis of oxidized LDL via the activation of the angiotensin II type 1 receptor
Takahashi, T., Huang, Y., Yamamoto, K., Hamano, G., Kakino, A., Kang, F., Imaizumi, Y., Takeshita, H., Nozato, Y., Nozato, S., Yokoyama, S., Nagasawa, M., Kawai, T., Takeda, T., Fujimoto, T., Hongyo, K., Nakagami, F., Akasaka, H., Takami, Y., Takeya, Y., Sugimoto, K., Gaisano, H.Y., Sawamura, T. and Rakugi, H.
ISCIENCE, 24, 102076, 2021年 - The relationship between serum levels of LOX-1 ligand containing ApoAI as a novel marker of dysfunctional HDL and coronary artery calcification in middle-aged Japanese men.
Hirata, A., Kakino, A., Okamura, T., Usami, Y., Fujita, Y., Kadota, A., Fujiyoshi, A., Hisamatsu, T., Kondo, K., Segawa, H., Sawamura, T., Miura, K. and Ueshima, H.
Atherosclerosis, 313, 20-25, 2020年 - LOX-1 deletion has protective effects on stroke in the genetic background of stroke-prone spontaneously hypertensive rat.
Liang, Y.Q., Kakino, A. (co-first author), Matsuzaka, Y., Mashimo, T., Isono, M., Akamatsu, T., Shimizu-Furusawa, H., Tajima, M., Kaneko, T., Li, L., Takeuchi, F., Sawamura, T. and Kato, N.
Stroke, 51, 1835-1843, 2020年 - LDL uptake-dependent phosphatidylethanolamine translocation to the cell surface promotes fusion of osteoclast-like cells.
Kitano, V.J.F., Ohyama, Y., Hayashida, C., Ito, J., Okayasu, M., Sato, T., Ogasawara, T., Tsujita, M., Kakino, A., Shimada, J., Sawamura, T. and Hakeda, Y.
J Cell Sci, 133, jcs243840, 2020年 - Detection of a high ratio of soluble to membrane-bound LOX-1 in aspirated coronary thrombi from patients with ST-segment-elevation myocardial infarction.
Lee, A.S., Wang, Y.C., Chang, S.S., Lo, P.H., Chang, C.M., Lu, J., Burns, A.R., Chen, C.H., Kakino, A., Sawamura, T. and Chang, K.C.
J Am Heart Assoc, 9, e014008, 2020年 - A novel cell-free, non-fluorescent method to measure LOX-1-binding activity corresponding to the functional activity of HDL.
Kakino, A., Usami, Y., Horiuchi, S., Fujita, Y., Kotani, K., Chen, C.H., Okamura, T. and Sawamura, T.
J Atheroscler Thromb, 26, 947-958, 2019年 - 123I-labeled oxLDL is widely distributed throughout the whole body in mice.
Nakano, A., Kawashima, H., Miyake, Y., Zeniya, T., Yamamoto, A., Koshino, K., Temma, T., Fukuda, T., Fujita, Y., Kakino, A., Kanaya, S., Sawamura, T. and Iida, H.
Nucl Med Mol Imaging, 52, 144-153, 2018年 - LOX-1 in ischemic stroke.
Sawamura, T., Fujita, Y., Horiuchi, S., Kakino, A.
J Atheroscler Thromb, 24, 566-568, 2017年 - L5: an LDL fraction in which pathogenic activity of LDL is concentrated.
Sawamura, T., Fujita, Y., Horiuchi, S., Kakino, A.
Trends Cardiovasc Med, 27, 247-248, 2017年 - Developmental endothelial locus-1 (Del-1) inhibits oxidized low-density lipoprotein activity by direct binding, and its overexpression attenuates atherogenesis in mice.
Kakino, A., Fujita, Y., Nakano, A., Horiuchi, S. and Sawamura, T.
Circ J, 80, 2541-2549, 2016年 - High levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 in acute stroke: an age- and sex-matched cross-sectional study.
Yokota, C., Sawamura, T., Watanabe, M., Kokubo, Y., Fujita, Y., Kakino, A., Nakai, M., Toyoda, K., Miyamoto, Y. and Minematsu, K.
J Atheroscler Thromb, 23, 1222-1226, 2016年 - Deletion of LOX-1 protects against heart failure induced by doxorubicin.
Yokoyama, C., Aoyama, T., Ido, T., Kakino, A., Shiraki, T., Tanaka, T., Nishigaki, K., Hasegawa, A., Fujita, Y., Sawamura, T. and Minatoguchi, S.
PLOS ONE, 11, e0154994, 2016年 - Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor.
Yamamoto, K., Kakino, A. (co-first author), Takeshita, H., Hayashi, N., Li, L., Nakano, A., Hanasaki-Yamamoto, H., Fujita, Y., Imaizumi, Y., Toyama-Yokoyama, S., Nakama, C., Kawai, T., Takeda, M., Hongyo, K., Oguro, R., Maekawa, Y., Itoh, N., Takami, Y., Onishi, M., Takeya, Y., Sugimoto, K., Kamide, K., Nakagami, H., Ohishi, M., Kurtz, T.W., Sawamura, T. and Rakugi, H.
FASEB J, 29, 3342-3356, 2015年 - Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state.
Nakayachi, M., Ito, J., Hayashida, C., Ohyama, Y., Kakino, A., Okayasu, M., Sato, T., Ogasawara, T., Kaneda, T., Suda, N., Sawamura, T. and Hakeda, Y.
BONE, 75, 170-182, 2015年 - LOX-1 ligands containing apolipoprotein B and carotid intima-media thickness in middle-aged community-dwelling US Caucasian and Japanese men.
Okamura, T., Sekikawa, A., Sawamura, T., Kadowaki, T., Barinas-Mitchell, E., Mackey, R.H., Kadota, A., Evans, R.W., Edmundowicz, D., Higashiyama, A., Nakamura, Y., Abbott, R.D., Miura, K., Fujiyoshi, A., Fujita, Y., Murakami, Y., Miyamatsu, N., Kakino, A., Maegawa, H., Murata, K., Horie, M., Mitsunami, K., Kashiwagi, A., Kuller, L.H., Ueshima, H. and Group, E.J.S.
Atherosclerosis, 229, 240-245, 2013年 - Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis.
Ishikawa, M., Ito, H., Akiyoshi, M., Kume, N., Yoshitomi, H., Mitsuoka, H., Tanida, S., Murata, K., Shibuya, H., Kasahara, T., Kakino, A., Fujita, Y., Sawamura, T., Yasuda, T. and Nakamura, T.
Arthritis Rheum, 64, 1024-1034, 2012年 - Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation.
Fujita, Y., Yamaguchi, S., Kakino, A., Iwamoto, S., Yoshimoto, R. and Sawamura, T.
Clin Chem, 57, 1398-1405, 2011年 - An alternative protein standard to measure activity of LOX-1 ligand containing apoB (LAB) - utilization of anti-LOX-1 single- chain antibody fused to apoB fragment.
Iwamoto, S., Fujita, Y., Kakino, A., Yanagida, K., Matsuda, H., Yoshimoto, R. and Sawamura, T.
J Atheroscler Thromb, 18, 818-828, 2011年 - Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox.
Nishizuka, T., Fujita, Y., Sato, Y., Nakano, A., Kakino, A., Ohshima, S., Kanda, T., Yoshimoto, R. and Sawamura, T.
Proc Jpn Acad Ser B Phys Biol Sci, 87, 104-113, 2011年 - Pitavastatin reduces lectin-like oxidized low-density lipoprotein receptor-1 ligands in hypercholesterolemic humans.
Matsumoto, T., Fujita, M., Sawamura, T., Kakino, A., Sato, Y., Fujita, Y., Matsuda, H., Nakanishi, M., Uchida, K., Nakae, I., Kanda, H., Yoshida, A., Miwa, K., Hayashi, H., Mitsunami, K. and Horie, M.
Lipids, 45, 329-335, 2010年 - LOX-1 mediates vascular lipid retention under hypertensive state.
Nakano, A., Inoue, N., Sato, Y., Nishimichi, N., Takikawa, K., Fujita, Y., Kakino, A., Otsui, K., Yamaguchi, S., Matsuda, H. and Sawamura, T.
J Hypertens, 28, 1273-1280, 2010年 - LOX index, a novel predictive biochemical marker for coronary heart disease and stroke.
Inoue, N., Okamura, T., Kokubo, Y., Fujita, Y., Sato, Y., Nakanishi, M., Yanagida, K., Kakino, A., Iwamoto, S., Watanabe, M., Ogura, S., Otsui, K., Matsuda, H., Uchida, K., Yoshimoto, R. and Sawamura, T.
Clin Chem, 56, 550-558, 2010年 - C-reactive protein uptake by macrophage cell line via class-A scavenger receptor.
Fujita, Y., Kakino, A., Harada-Shiba, M., Sato, Y., Otsui, K., Yoshimoto, R. and Sawamura, T.
Clin Chem, 56, 478-481, 2010年 - LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells.
Sugimoto, K., Ishibashi, T., Sawamura, T., Inoue, N., Kamioka, M., Uekita, H., Ohkawara, H., Sakamoto, T., Sakamoto, N., Okamoto, Y., Takuwa, Y., Kakino, A., Fujita, Y., Tanaka, T., Teramoto, T., Maruyama, Y. and Takeishi, Y.
Cardiovasc Res, 84, 127-136, 2009年 - Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects.
Fujita, Y., Kakino, A., Nishimichi, N., Yamaguchi, S., Sato, Y., Machida, S., Cominacini, L., Delneste, Y., Matsuda, H. and Sawamura, T.
Clin Chem, 55, 285-294, 2009年 - DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics.
Ikura, T., Tashiro, S., Kakino, A., Shima, H., Jacob, N., Amunugama, R., Yoder, K., Izumi, S., Kuraoka, I., Tanaka, K., Kimura, H., Ikura, M., Nishikubo, S., Ito, T., Muto, A., Miyagawa, K., Takeda, S., Fishel, R., Igarashi, K. and Kamiya, K.
Mol Cell Biol, 27, 7028-7040, 2007年
