医学博士

医学博士, 信州大学

ライフサイエンス, 血液、腫瘍内科学 , 骨髄不全症

ライフサイエンス, 腫瘍生物学 , 骨髄異形成症候群

ライフサイエンス, 血液、腫瘍内科学 , 骨髄異形成症候群

2024年 - 現在
信州大学, 学術研究院医学系医学部血液・腫瘍内科学教室, 教授

2018年 - 2023年
京都大学大学院医学研究科腫瘍生物学, Graduate School of Medicine, 准教授

2015年
京都大学大学院医学研究科腫瘍生物学, Graduate School of Medicine, 講師

2008年
クリーブランドクリニック, トーシックがんセンター, ポストドクトラルフェロー

2005年
信州大学医学部附属病院, 助教

2003年
信州大学医学部附属病院, Shinshu University Hospital, 医員

1999年
信州大学大学院医学研究科, 博士課程

1996年
信州大学医学部附属病院, Shinshu University Hospital, 内科ローテーション

1996年
名古屋大学医学部, School of Medicine

Whole-genome sequencing reveals genetic backgrounds in Japanese patients with hemophagocytic lymphohistiocytosis treated with the HLH-2004 protocol.
Ryu Yanagisawa; Manabu Wakamatsu; Dan Tomomasa; Kenichi Sakamoto; Rintaro Ono; Takehiko Doi; Ko Kudo; Hisanori Fujino; Kazuko Kudo; Akira Morimoto; Yoko Shioda; Takahiro Yasumi; Hideki Makishima; Hideki Muramatsu; Yoshiyuki Takahashi; Hirokazu Kanegane; Yozo Nakazawa
International journal of hematology, 2025年05月

Clinical-genomic profiling of MDS to inform allo-HCT: recommendations from an international panel on behalf of the EBMT.
Carmelo Gurnari; Marie Robin; Lionel Adès; Mahmoud Aljurf; Antonio Almeida; Fernando Barroso Duarte; Elsa Bernard; Corey Cutler; Matteo Giovanni Della Porta; Theo De Witte; Amy DeZern; Joanna Drozd-Sokolowska; Eric Duncavage; Pierre Fenaux; Nico Gagelmann; Guillermo Garcia-Manero; Claudia Haferlach; Torsten Haferlach; Robert Hasserjian; Eva Hellström-Lindberg; Meagan Jacoby; Austin Kulasekararaj; R Coleman Lindsley; Jaroslaw P Maciejewski; Hideki Makishima; Luca Malcovati; Moshe Mittelman; Anders E Myhre; Seishi Ogawa; Francesco Onida; Elli Papaemmanuil; Jakob Passweg; Uwe Platzbecker; Lisa Pleyer; Kavita Raj; Valeria Santini; Anna Sureda; Magnus Tobiasson; Maria Teresa Voso; Ibrahim Yakoub-Agha; Amer Zeidan; Matthew Walter; Nicolaus Kröger; Donal P McLornan; Mario Cazzola
Blood, 145(18), 1987-2001, 2025年05月

Association between gene mutations and outcomes in Japanese high-risk AML patients: a phase 1/2 study of NS-87/CPX-351.
Hideki Makishima; Taisuke Mikasa; Kento Isogaya; Toshihiro Miyamoto; Takuji Yamauchi; Akira Yokota; Masahiro Onozawa; Kiyoshi Ando; Yoshiaki Ogawa; Kensuke Usuki; Takahiro Yamauchi; Shuichi Ota; Satoru Takada; Yasuyoshi Morita; Takayuki Ishikawa; Katsuto Takenaka; Junya Kuroda; Naohiro Sekiguchi; Toshiro Kawakita; Yasushi Miyazaki
International journal of hematology, 2025年02月

Overall cancer risk in people with deleterious germline DDX41 variants.
Sophia C Korotev; Jason X Cheng; Yogameenakshi Haribabu; Joshua Strauss; Salina Dominguez; Ashwin Koppayi; Melody Perpich; Madeline Pies; Luke Moma; Aelin Kim; Hatice Basdag; Courtnee Rodgers; Satyajit Kosuri; Ryunosuke Saiki; Hideki Makishima; Sanjukta Tawde; Shelly Galasinski; Priscilla Kandikatla; Hari Prasanna Subramanian; Kehan Ren; Honghao Bi; Mona Mohammadhosseini; Seishi Ogawa; Peng Ji; Anupriya Agarwal; Soma Das; Lucy A Godley
Haematologica, 2025年02月

Genetic analysis of myeloid neoplasms with der(1;7)(q10;p10)
Rurika Okuda; Yotaro Ochi; Ryunosuke Saiki; Toshiyuki Yamanaka; Chikashi Terao; Tetsuichi Yoshizato; Masahiro M. Nakagawa; Lanying Zhao; Kazuma Ohyashiki; Nobuhiro Hiramoto; Masashi Sanada; Hiroshi Handa; Senji Kasahara; Yasushi Miyazaki; Nobuo Sezaki; Lee-Yung Shih; Wolfgang Kern; Nobuhiro Kanemura; Toshiyuki Kitano; Shinsaku Imashuku; Mitsumasa Watanabe; Maria Creignou; Kazuhisa Chonabayashi; Kensuke Usuki; Takayuki Ishikawa; Akihiko Gotoh; Yoshiko Atsuta; Yuichi Shiraishi; Kinuko Mitani; Shigeru Chiba; Akifumi Takaori-Kondo; Satoru Miyano; Yoichiro Kamatani; Torsten Haferlach; Eva Hellström-Lindberg; Koichi Matsuda; Yoshinori Yoshida; Hideki Makishima; Yasuhito Nannya; Seishi Ogawa
Leukemia, 2024年12月

Genetic profiles and clinical features in subcutaneous panniculitis-like T-cell lymphomas.
Yui Okamura; Kenichi Makishima; Yasuhito Suehara; Sakurako Suma; Yoshiaki Abe; Ryota Matsuoka; Tatsuhiro Sakamoto; Keiichiro Hattori; Yasuhisa Yokoyama; Takayasu Kato; Toru Nanmoku; Takeshi Iwasaki; Kenichi Nishiyama; Koji Kato; Yasuhide Takeuchi; Hideki Makishima; Naoya Nakamura; Shigeru Chiba; Mamiko Sakata-Yanagimoto
Cancer science, 115(11), 3788-3794, 2024年11月

Statistically and functionally fine-mapped blood eQTLs and pQTLs from 1,405 humans reveal distinct regulation patterns and disease relevance
Wang QS; Hasegawa T; Namkoong H; Saiki R; Edahiro R; Sonehara K; Tanaka H; Azekawa S; Chubachi S; Takahashi Y; Sakaue S; Namba S; Yamamoto K; Shiraishi Y; Chiba K; Tanaka H; Makishima H; Nannya Y; Zhang Z; Tsujikawa R; Koike R; Takano T; Ishii M; Kimura A; Inoue F; Kanai T; Fukunaga K; Ogawa S; Imoto S; Miyano S; Okada Y; Japan COVID; Task Force
Nature Genetics, 2024年09月

Germline predisposition traits in allogeneic hematopoietic stem-cell transplantation for myelodysplastic syndromes: a survey-based study and position paper on behalf of the Chronic Malignancies Working Party of the EBMT.
Carmelo Gurnari; Marie Robin; Lucy A Godley; Joanna Drozd-Sokołowska; Marcin W Włodarski; Kavita Raj; Francesco Onida; Nina Worel; Fabio Ciceri; Selim Carbacioglu; Michelle Kenyon; Mahmoud Aljurf; Carmem Bonfim; Hideki Makishima; Charlotte Niemeyer; Pierre Fenaux; Armin Zebisch; Nada Hamad; Yves Chalandon; Eva Hellström-Lindberg; Maria Teresa Voso; Cristina Mecucci; Fernando Barroso Duarte; Marie Sebert; Flore Sicre de Fontbrune; Jean Soulier; Akiko Shimamura; R Coleman Lindsley; Jarosław P Maciejewski; Rodrigo T Calado; Ibrahim Yakoub-Agha; Donal P McLornan
The Lancet. Haematology, 10(12), e994-e1005, 2023年12月

Postazacitidine clone size predicts long-term outcome of patients with myelodysplastic syndromes and related myeloid neoplasms.
Yasuhito Nannya; Magnus Tobiasson; Shinya Sato; Elsa Bernard; Shigeki Ohtake; June Takeda; Maria Creignou; Lanying Zhao; Manabu Kusakabe; Yuhei Shibata; Nobuhiko Nakamura; Mizuki Watanabe; Nobuhiro Hiramoto; Yusuke Shiozawa; Yuichi Shiraishi; Hiroko Tanaka; Kenichi Yoshida; Nobuyuki Kakiuchi; Hideki Makishima; Masahiro Nakagawa; Kensuke Usuki; Mitsumasa Watanabe; Kazunori Imada; Hiroshi Handa; Masataka Taguchi; Toru Kiguchi; Kazuma Ohyashiki; Takayuki Ishikawa; Akifumi Takaori-Kondo; Hisashi Tsurumi; Senji Kasahara; Shigeru Chiba; Tomoki Naoe; Satoru Miyano; Elli Papaemanuil; Yasushi Miyazaki; Eva Hellström-Lindberg; Seishi Ogawa
Blood advances, 7(14), 3624-3636, 2023年07月

Germline DDX41 mutations define a unique subtype of myeloid neoplasms.
Hideki Makishima; Ryunosuke Saiki; Yasuhito Nannya; Sophia Claire Korotev; Carmelo Gurnari; June Takeda; Yukihide Momozawa; Steven Best; Pramila Krishnamurthy; Tetsuichi Yoshizato; Yoshiko Atsuta; Yusuke Shiozawa; Yuka Iijima-Yamashita; Kenichi Yoshida; Yuichi Shiraishi; Yasunobu Nagata; Nobuyuki Kakiuchi; Makoto Onizuka; Kenichi Chiba; Hiroko Tanaka; Ayana Kon; Yotaro Ochi; Masahiro Marshall Nakagawa; Rurika Okuda; Takuto Mori; Akinori Yoda; Hidehiro Itonaga; Yasushi Miyazaki; Masashi Sanada; Takayuki Ishikawa; Shigeru Chiba; Hisashi Tsurumi; Senji Kasahara; Carsten Müller-Tidow; Akifumi Takaori-Kondo; Kazuma Ohyashiki; Toru Kiguchi; Fumihiko Matsuda; Joop H Jansen; Chantana Polprasert; Piers Blombery; Yoichiro Kamatani; Satoru Miyano; Luca Malcovati; Torsten Haferlach; Michiaki Kubo; Mario Cazzola; Austin G Kulasekararaj; Lucy A Godley; Jaroslaw P Maciejewski; Seishi Ogawa
Blood, 141(5), 534-549, 2022年11月

Amplified EPOR/JAK2 genes define a unique subtype of acute erythroid leukemia.
June Takeda; Kenichi Yoshida; Masahiro M Nakagawa; Yasuhito Nannya; Akinori Yoda; Ryunosuke Saiki; Yotaro Ochi; Lanying Zhao; Rurika Okuda; Xingxing Qi; Takuto Mori; Ayana Kon; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Ming-Chung Kuo; Cassandra M Kerr; Yasunobu Nagata; Daisuke Morishita; Nobuhiro Hiramoto; Akira Hangaishi; Hideyuki Nakazawa; Ken Ishiyama; Satoru Miyano; Shigeru Chiba; Yasushi Miyazaki; Toshiyuki Kitano; Kensuke Usuki; Nobuo Sezaki; Hisashi Tsurumi; Shuichi Miyawaki; Jaroslaw P Maciejewski; Takayuki Ishikawa; Kazuma Ohyashiki; Arnold Ganser; Michael Heuser; Felicitas Thol; Lee-Yung Shih; Akifumi Takaori-Kondo; Hideki Makishima; Seishi Ogawa
Blood cancer discovery, 3(5), 410-427, 2022年07月

The landscape of genetic aberrations in myxofibrosarcoma.
Yasuhide Takeuchi; Kenichi Yoshida; Adriane Halik; Annegret Kunitz; Hiromichi Suzuki; Nobuyuki Kakiuchi; Yusuke Shiozawa; Akira Yokoyama; Yoshikage Inoue; Tomonori Hirano; Tetsuichi Yoshizato; Kosuke Aoki; Yoichi Fujii; Yasuhito Nannya; Hideki Makishima; Berit Maria Pfitzner; Lars Bullinger; Masahiro Hirata; Keita Jinnouchi; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Takeshi Okamoto; Hironori Haga; Seishi Ogawa; Frederik Damm
International journal of cancer, 151(4), 565-577, 2022年04月

Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia
Yotaro Ochi; Kenichi Yoshida; Ying-Jung Huang; Ming-Chung Kuo; Yasuhito Nannya; Ko Sasaki; Kinuko Mitani; Noriko Hosoya; Nobuhiro Hiramoto; Takayuki Ishikawa; Susan Branford; Naranie Shanmuganathan; Kazuma Ohyashiki; Naoto Takahashi; Tomoiku Takaku; Shun Tsuchiya; Nobuhiro Kanemura; Nobuhiko Nakamura; Yasunori Ueda; Satoshi Yoshihara; Rabindranath Bera; Yusuke Shiozawa; Lanying Zhao; June Takeda; Yosaku Watatani; Rurika Okuda; Hideki Makishima; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Akifumi Takaori-Kondo; Satoru Miyano; Seishi Ogawa; Lee-Yung Shih
Nature Communications, 12(1), 2021年12月

Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis.
Ryunosuke Saiki; Yukihide Momozawa; Yasuhito Nannya; Masahiro M Nakagawa; Yotaro Ochi; Tetsuichi Yoshizato; Chikashi Terao; Yutaka Kuroda; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Atsushi Niida; Seiya Imoto; Koichi Matsuda; Takayuki Morisaki; Yoshinori Murakami; Yoichiro Kamatani; Shuichi Matsuda; Michiaki Kubo; Satoru Miyano; Hideki Makishima; Seishi Ogawa
Nature medicine, 27(7), 1239-1249, 2021年07月

Molecular classification and diagnostics of upper urinary tract urothelial carcinoma.
Yoichi Fujii; Yusuke Sato; Hiromichi Suzuki; Nobuyuki Kakiuchi; Tetsuichi Yoshizato; Andrew T Lenis; Shigekatsu Maekawa; Akira Yokoyama; Yasuhide Takeuchi; Yoshikage Inoue; Yotaro Ochi; Yusuke Shiozawa; Kosuke Aoki; Kenichi Yoshida; Keisuke Kataoka; Masahiro M Nakagawa; Yasuhito Nannya; Hideki Makishima; Jimpei Miyakawa; Taketo Kawai; Teppei Morikawa; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Genta Nagae; Masashi Sanada; Eiji Sugihara; Taka-Aki Sato; Tohru Nakagawa; Masashi Fukayama; Tetsuo Ushiku; Hiroyuki Aburatani; Satoru Miyano; Jonathan A Coleman; Yukio Homma; David B Solit; Haruki Kume; Seishi Ogawa
Cancer cell, 39(6), 793-809, 2021年06月

Frequent mutations in HLA and related genes in extranodal NK/T cell lymphomas.
Chantana Polprasert; Yasuhide Takeuchi; Hideki Makishima; Kitsada Wudhikarn; Nobuyuki Kakiuchi; Nichthida Tangnuntachai; Thamathorn Assanasen; Wimonmas Sitthi; Hamidah Muhamad; Panisinee Lawasut; Sunisa Kongkiatkamon; Udomsak Bunworasate; Koji Izutsu; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Seishi Ogawa; Kenichi Yoshida; Ponlapat Rojnuckarin
Leukemia & lymphoma, 62(1), 95-103, 2021年01月

Machine learning demonstrates that somatic mutations imprint invariant morphologic features in myelodysplastic syndromes.
Yasunobu Nagata; Ran Zhao; Hassan Awada; Cassandra M Kerr; Inom Mirzaev; Sunisa Kongkiatkamon; Aziz Nazha; Hideki Makishima; Tomas Radivoyevitch; Jacob G Scott; Mikkael A Sekeres; Brian P Hobbs; Jaroslaw P Maciejewski
Blood, 136(20), 2249-2262, 2020年11月

Landscape of driver mutations and their clinical impacts in pediatric B-cell precursor acute lymphoblastic leukemia.
Hiroo Ueno; Kenichi Yoshida; Yusuke Shiozawa; Yasuhito Nannya; Yuka Iijima-Yamashita; Nobutaka Kiyokawa; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Tomoya Isobe; Masafumi Seki; Shunsuke Kimura; Hideki Makishima; Masahiro M Nakagawa; Nobuyuki Kakiuchi; Keisuke Kataoka; Tetsuichi Yoshizato; Dai Nishijima; Takao Deguchi; Kentaro Ohki; Atsushi Sato; Hiroyuki Takahashi; Yoshiko Hashii; Sadao Tokimasa; Junichi Hara; Yoshiyuki Kosaka; Koji Kato; Takeshi Inukai; Junko Takita; Toshihiko Imamura; Satoru Miyano; Atsushi Manabe; Keizo Horibe; Seishi Ogawa; Masashi Sanada
Blood advances, 4(20), 5165-5173, 2020年10月

Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia.
Yihong Guan; Edward F Greenberg; Metis Hasipek; Shi Chen; Xiaochen Liu; Cassandra M Kerr; Daniel Gackowski; Ewelina Zarakowska; Tomas Radivoyevitch; Xiaorong Gu; Belinda Willard; Valeria Visconte; Hideki Makishima; Aziz Nazha; Mridul Mukherji; Mikkael A Sekeres; Yogen Saunthararajah; Ryszard Oliński; Mingjiang Xu; Jaroslaw P Maciejewski; Babal K Jha
Communications biology, 3(1), 493-493, 2020年09月

Founder and subclonal mutations in myelodysplastic syndromes and related myeloid neoplasms.
Hideki Makishima
Best practice & research. Clinical haematology, 33(3), 101189-101189, 2020年09月

Predisposed genomic instability in pre-treatment bone marrow evolves to therapy-related myeloid neoplasms in malignant lymphoma.
Seiichiro Katagiri; Hideki Makishima; Kenko Azuma; Yasuhito Nannya; Yuu Saitoh; Seiichiro Yoshizawa; Daigo Akahane; Hiroaki Fujimoto; Yoshikazu Ito; Ravi Velaga; Tomohiro Umezu; Junko H Ohyashiki; Seishi Ogawa; Kazuma Ohyashiki
Haematologica, 105(7), e337-e339, 2020年07月

Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes.
Yotaro Ochi; Ayana Kon; Toyonori Sakata; Masahiro M Nakagawa; Naotaka Nakazawa; Masanori Kakuta; Keisuke Kataoka; Haruhiko Koseki; Manabu Nakayama; Daisuke Morishita; Tatsuaki Tsuruyama; Ryunosuke Saiki; Akinori Yoda; Rurika Okuda; Tetsuichi Yoshizato; Kenichi Yoshida; Yusuke Shiozawa; Yasuhito Nannya; Shinichi Kotani; Yasunori Kogure; Nobuyuki Kakiuchi; Tomomi Nishimura; Hideki Makishima; Luca Malcovati; Akihiko Yokoyama; Kengo Takeuchi; Eiji Sugihara; Taka-Aki Sato; Masashi Sanada; Akifumi Takaori-Kondo; Mario Cazzola; Mineko Kengaku; Satoru Miyano; Katsuhiko Shirahige; Hiroshi I Suzuki; Seishi Ogawa
Cancer discovery, 10(6), 836-853, 2020年06月

Molecular pathogenesis of progression to myeloid leukemia from TET-insufficient status.
Raksha Shrestha; Mamiko Sakata-Yanagimoto; Koichiro Maie; Motohiko Oshima; Masatomo Ishihara; Yasuhito Suehara; Kota Fukumoto; Yaeko Nakajima-Takagi; Hirotaka Matsui; Takayasu Kato; Hideharu Muto; Tatsuhiro Sakamoto; Manabu Kusakabe; Yasuhito Nannya; Hideki Makishima; Hiroo Ueno; Ryunosuke Saiki; Seishi Ogawa; Kenichi Chiba; Yuichi Shiraishi; Satoru Miyano; Enguerran Mouly; Olivier A Bernard; Toshiya Inaba; Haruhiko Koseki; Atsushi Iwama; Shigeru Chiba
Blood advances, 4(5), 845-854, 2020年03月

Novel DDX41 variants in Thai patients with myeloid neoplasms.
Chantana Polprasert; June Takeda; Pimjai Niparuck; Thanawat Rattanathammethee; Arunrat Pirunsarn; Amornchai Suksusut; Sirorat Kobbuaklee; Kitsada Wudhikarn; Panisinee Lawasut; Sunisa Kongkiatkamon; Suporn Chuncharunee; Kritanan Songserm; Prasit Phowthongkum; Udomsak Bunworasate; Yasuhito Nannya; Kenichi Yoshida; Hideki Makishima; Seishi Ogawa; Ponlapat Rojnuckarin
International journal of hematology, 111(2), 241-246, 2020年02月

Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis.
Nobuyuki Kakiuchi; Kenichi Yoshida; Motoi Uchino; Takako Kihara; Kotaro Akaki; Yoshikage Inoue; Kenji Kawada; Satoshi Nagayama; Akira Yokoyama; Shuji Yamamoto; Minoru Matsuura; Takahiro Horimatsu; Tomonori Hirano; Norihiro Goto; Yasuhide Takeuchi; Yotaro Ochi; Yusuke Shiozawa; Yasunori Kogure; Yosaku Watatani; Yoichi Fujii; Soo Ki Kim; Ayana Kon; Keisuke Kataoka; Tetsuichi Yoshizato; Masahiro M Nakagawa; Akinori Yoda; Yasuhito Nanya; Hideki Makishima; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Eiji Sugihara; Taka-Aki Sato; Takashi Maruyama; Hiroyuki Miyoshi; Makoto Mark Taketo; Jun Oishi; Ryosaku Inagaki; Yutaka Ueda; Shinya Okamoto; Hideaki Okajima; Yoshiharu Sakai; Takaki Sakurai; Hironori Haga; Seiichi Hirota; Hiroki Ikeuchi; Hiroshi Nakase; Hiroyuki Marusawa; Tsutomu Chiba; Osamu Takeuchi; Satoru Miyano; Hiroshi Seno; Seishi Ogawa
Nature, 577(7789), 260-265, 2020年01月

Genome analysis of myelodysplastic syndromes among atomic bomb survivors in Nagasaki.
Masataka Taguchi; Hiroyuki Mishima; Yusuke Shiozawa; Chisa Hayashida; Akira Kinoshita; Yasuhito Nannya; Hideki Makishima; Makiko Horai; Masatoshi Matsuo; Shinya Sato; Hidehiro Itonaga; Takeharu Kato; Hiroaki Taniguchi; Daisuke Imanishi; Yoshitaka Imaizumi; Tomoko Hata; Motoi Takenaka; Yukiyoshi Moriuchi; Yuichi Shiraishi; Satoru Miyano; Seishi Ogawa; Koh-Ichiro Yoshiura; Yasushi Miyazaki
Haematologica, 105(2), 358-365, 2020年

Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling.
Yosaku Watatani; Yasuharu Sato; Hiroaki Miyoshi; Kana Sakamoto; Kenji Nishida; Yuka Gion; Yasunobu Nagata; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Lanying Zhao; Yotaro Ochi; Yasuhide Takeuchi; June Takeda; Hiroo Ueno; Yasunori Kogure; Yusuke Shiozawa; Nobuyuki Kakiuchi; Tetsuichi Yoshizato; Masahiro M Nakagawa; Yasuhito Nanya; Kenichi Yoshida; Hideki Makishima; Masashi Sanada; Mamiko Sakata-Yanagimoto; Shigeru Chiba; Ryota Matsuoka; Masayuki Noguchi; Nobuhiro Hiramoto; Takayuki Ishikawa; Junichi Kitagawa; Nobuhiko Nakamura; Hisashi Tsurumi; Tatsuhiko Miyazaki; Yusuke Kito; Satoru Miyano; Kazuya Shimoda; Kengo Takeuchi; Koichi Ohshima; Tadashi Yoshino; Seishi Ogawa; Keisuke Kataoka
Leukemia, 33(12), 2867-2883, 2019年12月

Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes.
Yasunobu Nagata; Hideki Makishima; Cassandra M Kerr; Bartlomiej P Przychodzen; Mai Aly; Abhinav Goyal; Hassan Awada; Mohammad Fahad Asad; Teodora Kuzmanovic; Hiromichi Suzuki; Tetsuichi Yoshizato; Kenichi Yoshida; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Satoru Miyano; Sudipto Mukherjee; Thomas LaFramboise; Aziz Nazha; Mikkael A Sekeres; Tomas Radivoyevitch; Torsten Haferlach; Seishi Ogawa; Jaroslaw P Maciejewski
Nature communications, 10(1), 5386-5386, 2019年11月

Distinct clinical and biological implications of CUX1 in myeloid neoplasms.
Mai Aly; Zubaidah M Ramdzan; Yasunobu Nagata; Suresh K Balasubramanian; Naoko Hosono; Hideki Makishima; Valeria Visconte; Teodora Kuzmanovic; Vera Adema; Aziz Nazha; Bartlomiej P Przychodzen; Cassandra M Kerr; Mikkael A Sekeres; Mohamed E Abazeed; Alain Nepveu; Jaroslaw P Maciejewski
Blood advances, 3(14), 2164-2178, 2019年07月

Frequent structural variations involving programmed death ligands in Epstein-Barr virus-associated lymphomas.
Keisuke Kataoka; Hiroaki Miyoshi; Seiji Sakata; Akito Dobashi; Lucile Couronné; Yasunori Kogure; Yasuharu Sato; Kenji Nishida; Yuka Gion; Yuichi Shiraishi; Hiroko Tanaka; Kenichi Chiba; Yosaku Watatani; Nobuyuki Kakiuchi; Yusuke Shiozawa; Tetsuichi Yoshizato; Kenichi Yoshida; Hideki Makishima; Masashi Sanada; Masahiro Onozawa; Takanori Teshima; Yumiko Yoshiki; Tadao Ishida; Kenshi Suzuki; Kazuyuki Shimada; Akihiro Tomita; Motohiro Kato; Yasunori Ota; Koji Izutsu; Ayako Demachi-Okamura; Yoshiki Akatsuka; Satoru Miyano; Tadashi Yoshino; Philippe Gaulard; Olivier Hermine; Kengo Takeuchi; Koichi Ohshima; Seishi Ogawa
Leukemia, 33(7), 1687-1699, 2019年07月

Molecular pathogenesis of disease progression in MLL-rearranged AML.
Shinichi Kotani; Akinori Yoda; Ayana Kon; Keisuke Kataoka; Yotaro Ochi; Yusuke Shiozawa; Cassandra Hirsch; June Takeda; Hiroo Ueno; Tetsuichi Yoshizato; Kenichi Yoshida; Masahiro M Nakagawa; Yasuhito Nannya; Nobuyuki Kakiuchi; Takuji Yamauchi; Kosuke Aoki; Yuichi Shiraishi; Satoru Miyano; Takahiro Maeda; Jaroslaw P Maciejewski; Akifumi Takaori-Kondo; Seishi Ogawa; Hideki Makishima
Leukemia, 33(3), 612-624, 2019年03月

Frequent germline mutations of HAVCR2 in sporadic subcutaneous panniculitis-like T-cell lymphoma.
Chantana Polprasert; Yasuhide Takeuchi; Nobuyuki Kakiuchi; Kenichi Yoshida; Thamathorn Assanasen; Wimonmas Sitthi; Udomsak Bunworasate; Arunrat Pirunsarn; Kitsada Wudhikarn; Panisinee Lawasut; Noppacharn Uaprasert; Sunisa Kongkiatkamon; Chatphatai Moonla; Masashi Sanada; Nobuhiro Akita; June Takeda; Yoichi Fujii; Hiromichi Suzuki; Yasuhito Nannya; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Ponlapat Rojnuckarin; Seishi Ogawa; Hideki Makishima
Blood advances, 3(4), 588-595, 2019年02月

Age-related remodelling of oesophageal epithelia by mutated cancer drivers.
Akira Yokoyama; Nobuyuki Kakiuchi; Tetsuichi Yoshizato; Yasuhito Nannya; Hiromichi Suzuki; Yasuhide Takeuchi; Yusuke Shiozawa; Yusuke Sato; Kosuke Aoki; Soo Ki Kim; Yoichi Fujii; Kenichi Yoshida; Keisuke Kataoka; Masahiro M Nakagawa; Yoshikage Inoue; Tomonori Hirano; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Yoshitaka Nishikawa; Yusuke Amanuma; Shinya Ohashi; Ikuo Aoyama; Takahiro Horimatsu; Shin'ichi Miyamoto; Shigeru Tsunoda; Yoshiharu Sakai; Maiko Narahara; J B Brown; Yoshitaka Sato; Genta Sawada; Koshi Mimori; Sachiko Minamiguchi; Hironori Haga; Hiroshi Seno; Satoru Miyano; Hideki Makishima; Manabu Muto; Seishi Ogawa
Nature, 565(7739), 312-317, 2019年01月

[Genomic aberrations in myelodysplastic syndromes and related disorders].
Hideki Makishima
[Rinsho ketsueki] The Japanese journal of clinical hematology, 60(6), 600-609, 2019年

Germline loss-of-function SAMD9 and SAMD9L alterations in adult myelodysplastic syndromes.
Yasunobu Nagata; Satoshi Narumi; Yihong Guan; Bartlomiej P Przychodzen; Cassandra M Hirsch; Hideki Makishima; Hirohito Shima; Mai Aly; Victor Pastor; Teodora Kuzmanovic; Tomas Radivoyevitch; Vera Adema; Hassan Awada; Kenichi Yoshida; Samuel Li; Francesc Sole; Rabi Hanna; Babal K Jha; Thomas LaFramboise; Seishi Ogawa; Mikkael A Sekeres; Marcin W Wlodarski; Jörg Cammenga; Jaroslaw P Maciejewski
Blood, 132(21), 2309-2313, 2018年11月

Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia.
Shiozawa Y; Malcovati L; Gallì A; Sato-Otsubo A; Kataoka K; Sato Y; Watatani Y; Suzuki H; Yoshizato T; Yoshida K; Sanada M; Makishima H; Shiraishi Y; Chiba K; Hellström-Lindberg E; Miyano S; Ogawa S; Cazzola M
Nature communications, 9(1), 3649-3649, 2018年09月

Hidden FLT3-D835Y clone in FLT3-ITD-positive acute myeloid leukemia that evolved into very late relapse with T-lymphoblastic leukemia
Seiichiro Katagiri; Tomohiro Umezu; Kenko Azuma; Michiyo Asano; Daigo Akahane; Hideki Makishima; Kenichi Yoshida; Yosaku Watatani; Kenichi Chiba; Satoru Miyano; Seishi Ogawa; Junko H. Ohyashiki; Kazuma Ohyashiki
Leukemia and Lymphoma, 59(6), 1490-1493, 2018年06月

Idh1/2 mutations sensitize acute myeloid leukemia to parp inhibition and this is reversed by idh1/2-mutant inhibitors
Remco J. Molenaar; Tomas Radivoyevitch; Yasunobu Nagata; Mohammed Khurshed; Bartolomiej Przychodzen; Hideki Makishima; Mingjiang Xu; Fonnet E. Bleeker; Johanna W. Wilmink; Hetty E. Carraway; Sudipto Mukherjee; Mikkael A. Sekeres; Cornelis J.F. van Noorden; Jaroslaw P. Maciejewski
Clinical Cancer Research, 24(7), 1705-1715, 2018年04月

Clonal PIGA mosaicism and dynamics in paroxysmal nocturnal hemoglobinuria.
Clemente MJ; Przychodzen B; Hirsch CM; Nagata Y; Bat T; Wlodarski MW; Radivoyevitch T; Makishima H; Maciejewski JP
Leukemia, 32(11), 2507-2511, 2018年04月

A novel genetic and morphologic phenotype of ARID2-mediated myelodysplasia
H. Sakai; N. Hosono; H. Nakazawa; B. Przychodzen; C. Polprasert; H. E. Carraway; M. A. Sekeres; T. Radivoyevitch; K. Yoshida; M. Sanada; T. Yoshizato; K. Kataoka; M. M. Nakagawa; H. Ueno; Y. Nannya; A. Kon; Y. Shiozawa; J. Takeda; Y. Shiraishi; K. Chiba; S. Miyano; J. Singh; R. A. Padgett; S. Ogawa; J. P. Maciejewski; H. Makishima
Leukemia, 32(3), 839-843, 2018年03月

Fanconi Anemia germline variants as susceptibility factors in aplastic anemia, MDS and AML.
Przychodzen B; Makishima H; Sekeres MA; Balasubramanian SK; Thota S; Patel BJ; Clemente M; Hirsch C; Dienes B; Maciejewski JP
Oncotarget, 9(2), 2050-2057, 2018年01月

[Clonal hematopoiesis in aplastic anemia].
Makishima H
[Rinsho ketsueki] The Japanese journal of clinical hematology, 59(10), 1962-1968, 2018年

Genomic determinants of chronic myelomonocytic leukemia
B. J. Patel; B. Przychodzen; S. Thota; T. Radivoyevitch; V. Visconte; T. Kuzmanovic; M. Clemente; C. Hirsch; A. Morawski; R. Souaid; C. Saygin; A. Nazha; B. Demarest; T. LaFramboise; H. Sakaguchi; S. Kojima; H. E. Carraway; S. Ogawa; H. Makishima; M. A. Sekeres; J. P. Maciejewski
LEUKEMIA, 31(12), 2815-2823, 2017年12月

Gene expression and risk of leukemic transformation in myelodysplasia
Yusuke Shiozawa; Luca Malcovati; Anna Galli; Andrea Pellagatti; Mohsen Karimi; Aiko Sato-Otsubo; Yusuke Sato; Hiromichi Suzuki; Tetsuichi Yoshizato; Kenichi Yoshida; Yuichi Shiraishi; Kenichi Chiba; Hideki Makishima; Jacqueline Boultwood; Eva Hellstrom-Lindberg; Satoru Miyano; Mario Cazzola; Seishi Ogawa
BLOOD, 130(24), 2642-2653, 2017年12月

Origins of myelodysplastic syndromes after aplastic anemia
Eiju Negoro; Yasunobu Nagata; Michael J. Clemente; Naoko Hosono; Wenyi Shen; Aziz Nazha; Tetsuichi Yoshizato; Cassandra Hirsch; Bartlomiej Przychodzen; Reda Z. Mahfouz; Teodora Kuzmanovic; Mikkael A. Sekeres; Hideki Makishima; Seishi Ogawa; Jaroslaw P. Maciejewski
BLOOD, 130(17), 1953-1957, 2017年10月

GATA4 loss of function in liver cancer impedes precursor to hepatocyte transition
Francis O. Enane; Wai Ho Shuen; Xiaorong Gu; Ebrahem Quteba; Bartlomiej Przychodzen; Hideki Makishima; Juraj Bodo; Joanna Ng; Chit Lai Chee; Rebecca Ba; Lip Seng Koh; Janice Lim; Rachael Cheong; Marissa Teo; Zhenbo Hu; Kwok Peng Ng; Jaroslaw Maciejewski; Tomas Radivoyevitch; Alexander Chung; London Lucien Ooi; Yu Meng Tan; Peng-Chung Cheow; Pierce Chow; Chung Yip Chan; Kiat Hon Lim; Lisa Yerian; Eric Hsi; Han Chong Toh; Yogen Saunthararajah
JOURNAL OF CLINICAL INVESTIGATION, 127(9), 3527-3542, 2017年09月

Molecular features of early onset adult myelodysplastic syndrome
Cassandra M. Hirsch; Bartlomiej P. Przychodzen; Tomas Radivoyevitch; Bhumika Patel; Swapna Thota; Michael J. Clemente; Yasunobu Nagata; Thomas LaFramboise; Hetty E. Carraway; Aziz Nazha; Mikkael A. Sekeres; Hideki Makishima; Jaroslaw P. Maciejewski
HAEMATOLOGICA, 102(6), 1028-1034, 2017年06月

Somatic SETBP1 mutations in myeloid neoplasms
Hideki Makishima
INTERNATIONAL JOURNAL OF HEMATOLOGY, 105(6), 732-742, 2017年06月

Deletion of Ptpn1 induces myeloproliferative neoplasm
F. Jobe; B. Patel; T. Kuzmanovic; H. Makishima; Y. Yang; B. Przychodzen; R. E. Hutchison; K. K. Bence; J. P. Maciejewski; G. Mohi
LEUKEMIA, 31(5), 1229-1234, 2017年05月

Genetic abnormalities in myelodysplasia and secondary acute myeloid leukemia: impact on outcome of stem cell transplantation
Tetsuichi Yoshizato; Yasuhito Nannya; Yoshiko Atsuta; Yusuke Shiozawa; Yuka Iijima-Yamashita; Kenichi Yoshida; Yuichi Shiraishi; Hiromichi Suzuki; Yasunobu Nagata; Yusuke Sato; Nobuyuki Kakiuchi; Keitaro Matsuo; Makoto Onizuka; Keisuke Kataoka; Kenichi Chiba; Hiroko Tanaka; Hiroo Ueno; Masahiro M. Nakagawa; Bartlomiej Przychodzen; Claudia Haferlach; Wolfgang Kern; Kosuke Aoki; Hidehiro Itonaga; Yoshinobu Kanda; Mikkael A. Sekeres; Jaroslaw P. Maciejewski; Torsten Haferlach; Yasushi Miyazaki; Keizo Horibe; Masashi Sanada; Satoru Miyano; Hideki Makishima; Seishi Ogawa
BLOOD, 129(17), 2347-2358, 2017年04月

Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells
Feng Pan; Thomas S. Wingo; Zhigang Zhao; Rui Gao; Hideki Makishima; Guangbo Qu; Li Lin; Miao Yu; Janice R. Ortega; Jiapeng Wang; Aziz Nazha; Li Chen; Bing Yao; Can Liu; Shi Chen; Ophelia Weeks; Hongyu Ni; Brittany Lynn Phillips; Suming Huang; Jianlong Wang; Chuan He; Guo-Min Li; Tomas Radivoyevitch; Iannis Aifantis; Jaroslaw P. Maciejewski; Feng-Chun Yang; Peng Jin; Mingjiang Xu
NATURE COMMUNICATIONS, 8, 15102, 2017年04月

A myeloid tumor suppressor role for NOL3
Robert F. Stanley; Richard T. Piszczatowski; Boris Bartholdy; Kelly Mitchell; Wendy M. McKimpson; Swathi Narayanagari; Dagmar Walter; Tihomira I. Todorova; Cassandra Hirsch; Hideki Makishima; Britta Will; Christine McMahon; Kira Gritsman; Jaroslaw P. Maciejewski; Richard N. Kitsis; Ulrich Steidl
JOURNAL OF EXPERIMENTAL MEDICINE, 214(3), 753-771, 2017年03月

Dynamics of clonal evolution in myelodysplastic syndromes
Hideki Makishima; Tetsuichi Yoshizato; Kenichi Yoshida; Mikkael A. Sekeres; Tomas Radivoyevitch; Hiromichi Suzuki; Bartlomiej Przychodzen; Yasunobu Nagata; Manja Meggendorfer; Masashi Sanada; Yusuke Okuno; Cassandra Hirsch; Teodora Kuzmanovic; Yusuke Sato; Aiko Sato-Otsubo; Thomas LaFramboise; Naoko Hosono; Yuichi Shiraishi; Kenichi Chiba; Claudia Haferlach; Wolfgang Kern; Hiroko Tanaka; Yusuke Shiozawa; Ines Gomez-Segui; Holleh D. Husseinzadeh; Swapna Thota; Kathryn M. Guinta; Brittney Dienes; Tsuyoshi Nakamaki; Shuichi Miyawaki; Yogen Saunthararajah; Shigeru Chiba; Satoru Miyano; Lee-Yung Shih; Torsten Haferlach; Seishi Ogawa; Jaroslaw P. Maciejewski
NATURE GENETICS, 49(2), 204-212, 2017年02月

Recurrent genetic defects on chromosome 5q in myeloid neoplasms
Naoko Hosono; Hideki Makishima; Reda Mahfouz; Bartlomiej Przychodzen; Kenichi Yoshida; Andres Jerez; Thomas LaFramboise; Chantana Polprasert; Michael J. Clemente; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Masashi Sanada; Edward Cui; Amit K. Verma; Michael A. McDevitt; Alan F. List; Yogen Saunthararajah; Mikkael A. Sekeres; Jacqueline Boultwood; Seishi Ogawa; Jaroslaw P. Maciejewski
ONCOTARGET, 8(4), 6483-6495, 2017年01月

Sequential acquisition of mutations in myelodysplastic syndromes.
Makishima H
[Rinsho ketsueki] The Japanese journal of clinical hematology, 58(10), 1828-1837, 2017年

Molecular predictors of response in patients with myeloid neoplasms treated with lenalidomide
E. Negoro; T. Radivoyevitch; C. Polprasert; V. Adema; N. Hosono; H. Makishima; B. Przychodzen; C. Hirsch; M. J. Clemente; A. Nazha; V. Santini; K. L. McGraw; A. F. List; F. Sole; M. A. Sekeres; J. P. Maciejewski
LEUKEMIA, 30(12), 2405-2409, 2016年12月

Somatic mosaicism in chronic myeloid leukemia in remission
Kinuko Mitani; Yasunobu Nagata; Ko Sasaki; Kenichi Yoshida; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Satoru Miyano; Hideki Makishima; Yukitsugu Nakamura; Yuka Nakamura; Motoshi Ichikawa; Seishi Ogawa
BLOOD, 128(24), 2863-2866, 2016年12月

Somatic PHF6 mutations in 1760 cases with various myeloid neoplasms
T. Mori; Y. Nagata; H. Makishima; M. Sanada; Y. Shiozawa; A. Kon; T. Yoshizato; A. Sato-Otsubo; K. Kataoka; Y. Shiraishi; K. Chiba; H. Tanaka; K. Ishiyama; S. Miyawaki; H. Mori; T. Nakamaki; R. Kihara; H. Kiyoi; H. P. Koeffler; L-Y Shih; S. Miyano; T. Naoe; C. Haferlach; W. Kern; T. Haferlach; S. Ogawa; K. Yoshida
LEUKEMIA, 30(11), 2270-2273, 2016年11月

Epigenetic therapy as a novel approach for GFI136N-associated murine/human AML
Lacramioara Botezatu; Lars C. Michel; Anne Helness; Charles Vadnais; Hideki Makishima; Judith M. Hoenes; Francois Robert; Lothar Vassen; Aniththa Thivakaran; Yahya Al-Matary; Robert F. Lams; Judith Schuette; Bernd Giebel; Andre Goergens; Michael Heuser; Hind Medyouf; Jaroslaw Maciejewski; Ulrich Duehrsen; Tarik Moeroey; Cyrus Khandanpour
EXPERIMENTAL HEMATOLOGY, 44(8), 713-726, 2016年08月

GFI1(36N) as a therapeutic and prognostic marker for myelodysplastic syndrome
Lacramioara Botezatu; Lars C. Michel; Hideki Makishima; Thomas Schroeder; Ulrich Germing; Rainer Haas; Bert van der Reijden; Anne E. Marneth; Saskia M. Bergevoet; Joop H. Jansen; Bartlomiej Przychodzen; Marcin Wlodarski; Charlotte Niemeyer; Uwe Platzbecker; Gerhard Ehninger; Ashwin Unnikrishnan; Dominik Beck; John Pimanda; Eva Hellstrom-Lindberg; Luca Malcovati; Jacqueline Boultwood; Andrea Pellagatti; Elli Papaemmanuil; Philipp Le Coutre; Jaspal Kaeda; Bertram Opalka; Tarik Moroy; Ulrich Duehrsen; Jaroslaw Maciejewski; Cyrus Khandanpour
EXPERIMENTAL HEMATOLOGY, 44(7), 590-595, 2016年07月

GFI1 as a novel prognostic and therapeutic factor for AML/MDS
J. M. Hoenes; L. Botezatu; A. Helness; C. Vadnais; L. Vassen; F. Robert; S. M. Hergenhan; A. Thivakaran; J. Schuette; Y. S. Al-Matary; R. F. Lams; J. Fraszscak; H. Makishima; T. Radivoyevitch; B. Przychodzen; S. V. da Conceicao Castro; A. Goergens; B. Giebel; L. Klein-Hitpass; K. Lennartz; M. Heuser; C. Thiede; G. Ehninger; U. Duehrsen; J. P. Maciejewski; T. Moeroey; C. Khandanpour
LEUKEMIA, 30(6), 1237-1245, 2016年06月

Impact of allogeneic hematopoietic cell transplant in patients with myeloid neoplasms carrying spliceosomal mutations
Betty Ky Hamilton; Valeria Visconte; Xuefei Jia; Ali Tabarroki; Hideki Makishima; Edy Hasrouni; Donna Abounader; Matt Kalaycio; Mikkael A. Sekeres; Ronald Sobecks; Hien Duong Liu; Brian Bolwell; Jaroslaw P. Maciejewski; Edward Copelan; Ramon V. Tiu
AMERICAN JOURNAL OF HEMATOLOGY, 91(4), 406-409, 2016年04月

Angioimmunoblastic T-cell Lymphomas With the RHOA p.Gly17Val Mutation Have Classic Clinical and Pathologic Features
Sarah L. Ondrejka; Bartosz Grzywacz; Juraj Bodo; Hideki Makishima; Chantana Polprasert; Jonathan W. Said; Bartlomiej Przychodzen; Jaroslaw P. Maciejewski; Eric D. Hsi
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 40(3), 335-341, 2016年03月

Runx1 repression by histone deacetylation is critical for Setbp1-induced mouse myeloid leukemia development
B. A. Vishwakarma; N. Nguyen; H. Makishima; N. Hosono; K. O. Gudmundsson; V. Negi; K. Oakley; Y. Han; B. Przychodzen; J. P. Maciejewski; Y. Du
LEUKEMIA, 30(1), 200-208, 2016年01月

Gene mutations in bone marrow failure syndromes.
Yoshizato T; Makishima H
[Rinsho ketsueki] The Japanese journal of clinical hematology, 57(12), 2519-2525, 2016年

Gene mutations in myelodysplastic syndromes.
Makishima H; Ogawa S
[Rinsho ketsueki] The Japanese journal of clinical hematology, 57(12), 2543-2553, 2016年

Whole-exome sequencing enhances prognostic classification of myeloid malignancies
Matthew Ruffalo; Holleh Husseinzadeh; Hideki Makishima; Bartlomiej Przychodzen; Mohamed Ashkar; Mehmet Koyutuerk; Jaroslaw P. Maciejewski; Thomas LaFramboise
JOURNAL OF BIOMEDICAL INFORMATICS, 58, 104-113, 2015年12月

Aberrant DNA Methylation Is Associated with a Poor Outcome in Juvenile Myelomonocytic Leukemia
Hirotoshi Sakaguchi; Hideki Muramatsu; Yusuke Okuno; Hideki Makishima; Yinyan Xu; Yoko Furukawa-Hibi; Xinan Wang; Atsushi Narita; Kenichi Yoshida; Yuichi Shiraishi; Sayoko Doisaki; Nao Yoshida; Asahito Hama; Yoshiyuki Takahashi; Kiyofumi Yamada; Satoru Miyano; Seishi Ogawa; Jaroslaw P. Maciejewski; Seiji Kojima
PLOS ONE, 10(12), e0145394, 2015年12月

Clinical and biological implications of ancestral and non-ancestral IDH1 and IDH2 mutations in myeloid neoplasms
R. J. Molenaar; S. Thota; Y. Nagata; B. Patel; M. Clemente; B. Przychodzen; C. Hirsh; A. D. Viny; N. Hosano; F. E. Bleeker; M. Meggendorfer; T. Alpermann; Y. Shiraishi; K. Chiba; H. Tanaka; C. J. F. van Noorden; T. Radivoyevitch; H. E. Carraway; H. Makishima; S. Miyano; M. A. Sekeres; S. Ogawa; T. Haferlach; J. P. Maciejewski
LEUKEMIA, 29(11), 2134-2142, 2015年11月

Genomic patterns associated with hypoplastic compared to hyperplastic myelodysplastic syndromes
Aziz Nazha; David Seastone; Tom Radivoyevitch; Bartlomiej Przychodzen; Hetty E. Carraway; Bhumika J. Patel; Jennifer Carew; Hideki Makishima; Mikkael A. Sekeres; Jaroslaw P. Maciejewski
HAEMATOLOGICA, 100(11), E434-E437, 2015年11月

New IDH1 mutant inhibitors for treatment of acute myeloid leukemia
Ujunwa C. Okoye-Okafor; Boris Bartholdy; Jessy Cartier; Enoch N. Gao; Beth Pietrak; Alan R. Rendina; Cynthia Rominger; Chad Quinn; Angela Smallwood; Kenneth J. Wiggall; Alexander J. Reif; Stanley J. Schmidt; Hongwei Qi; Huizhen Zhao; Gerard Joberty; Maria Faelth-Savitski; Marcus Bantscheff; Gerard Drewes; Chaya Duraiswami; Pat Brady; Arthur Groy; Swathi-Rao Narayanagari; Ileana Antony-Debre; Kelly Mitchell; Heng Rui Wang; Yun-Ruei Kao; Maximilian Christopeit; Luis Carvajal; Laura Barreyro; Elisabeth Paietta; Hideki Makishima; Britta Will; Nestor Concha; Nicholas D. Adams; Benjamin Schwartz; Michael T. McCabe; Jaroslav Maciejewski; Amit Verma; Ulrich Steidl
NATURE CHEMICAL BIOLOGY, 11(11), 878-U107, 2015年11月

Integrated molecular analysis of adult T cell leukemia/lymphoma
Keisuke Kataoka; Yasunobu Nagata; Akira Kitanaka; Yuichi Shiraishi; Teppei Shimamura; Jun-Ichirou Yasunaga; Yasushi Totoki; Kenichi Chiba; Aiko Sato-Otsubo; Genta Nagae; Ryohei Ishii; Satsuki Muto; Shinichi Kotani; Yosaku Watatani; June Takeda; Masashi Sanada; Hiroko Tanaka; Hiromichi Suzuki; Yusuke Sato; Yusuke Shiozawa; Tetsuichi Yoshizato; Kenichi Yoshida; Hideki Makishima; Masako Iwanaga; Guangyong Ma; Kisato Nosaka; Masakatsu Hishizawa; Hidehiro Itonaga; Yoshitaka Imaizumi; Wataru Munakata; Hideaki Ogasawara; Toshitaka Sato; Ken Sasai; Kenzo Muramoto; Marina Penova; Takahisa Kawaguchi; Hiromi Nakamura; Natsuko Hama; Kotaro Shide; Yoko Kubuki; Tomonori Hidaka; Takuro Kameda; Tsuyoshi Nakamaki; Ken Ishiyama; Shuichi Miyawaki; Sung-Soo Yoon; Kensei Tobinai; Yasushi Miyazaki; Akifumi Takaori-Kondo; Fumihiko Matsuda; Kengo Takeuchi; Osamu Nureki; Hiroyuki Aburatani; Toshiki Watanabe; Tatsuhiro Shibata; Masao Matsuoka; Satoru Miyano; Kazuya Shimoda; Seishi Ogawa
NATURE GENETICS, 47(11), 1304-+, 2015年11月

GATA2 and secondary mutations in familial myelodysplastic syndromes and pediatric myeloid malignancies
Xinan Wang; Hideki Muramatsu; Yusuke Okuno; Hirotoshi Sakaguchi; Kenichi Yoshida; Nozomu Kawashima; Yinyan Xu; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Shoji Saito; Yozo Nakazawa; Taro Masunari; Tadashi Hirose; Shaimaa Elmahdi; Atsushi Narita; Sayoko Doisaki; Olfat Ismael; Hideki Makishima; Asahito Hama; Satoru Miyano; Yoshiyuki Takahashi; Seishi Ogawa; Seiji Kojima
HAEMATOLOGICA, 100(10), E398-E401, 2015年10月

BRCC3 mutations in myeloid neoplasms
Dayong Huang; Yasunobu Nagata; Vera Grossmann; Tomas Radivoyevitch; Yusuke Okuno; Genta Nagae; Naoko Hosono; Susanne Schnittger; Masashi Sanada; Bartlomiej Przychodzen; Ayana Kon; Chantana Polprasert; Wenyi Shen; Michael J. Clemente; James G. Phillips; Tamara Alpermann; Kenichi Yoshida; Niroshan Nadarajah; Mikkael A. Sekeres; Kevin Oakley; Nhu Nguyen; Yuichi Shiraishi; Yusuke Shiozawa; Kenichi Chiba; Hiroko Tanaka; H. Phillip Koeffler; Hans-Ulrich Klein; Martin Dugas; Hiroyuki Aburatani; Satoru Miyano; Claudia Haferlach; Wolfgang Kern; Torsten Haferlach; Yang Du; Seishi Ogawa; Hideki Makishima
HAEMATOLOGICA, 100(8), 1051-1057, 2015年08月

Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia
T. Yoshizato; B. Dumitriu; K. Hosokawa; H. Makishima; K. Yoshida; D. Townsley; A. Sato-Otsubo; Y. Sato; D. Liu; H. Suzuki; C. O. Wu; Y. Shiraishi; M. J. Clemente; K. Kataoka; Y. Shiozawa; Y. Okuno; K. Chiba; H. Tanaka; Y. Nagata; T. Katagiri; A. Kon; M. Sanada; P. Scheinberg; S. Miyano; J. P. Maciejewski; S. Nakao; N. S. Young; S. Ogawa
NEW ENGLAND JOURNAL OF MEDICINE, 373(1), 35-47, 2015年07月

Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms
Chantana Polprasert; Isabell Schulze; Mikkael A. Sekeres; Hideki Makishima; Bartlomiej Przychodzen; Naoko Hosono; Jarnail Singh; Richard A. Padgett; Xiaorong Gu; James G. Phillips; Michael Clemente; Yvonne Parker; Daniel Lindner; Brittney Dienes; Eckhard Jankowsky; Yogen Saunthararajah; Yang Du; Kevin Oakley; Nhu Nguyen; Sudipto Mukherjee; Caroline Pabst; Lucy A. Godley; Jane E. Churpek; Daniel A. Pollyea; Utz Krug; Wolfgang E. Berdel; Hans-Ulrich Klein; Martin Dugas; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Kenichi Yoshida; Seishi Ogawa; Carsten Mueller-Tidow; Jaroslaw P. Maciejewski
CANCER CELL, 27(5), 658-670, 2015年05月

Genetic and molecular characterization of myelodysplastic syndromes and related myeloid neoplasms
Bhumika Patel; Cassandra Hirsch; Michael Clemente; Mikkael Sekeres; Hideki Makishima; Jaroslaw P. Maciejewski
INTERNATIONAL JOURNAL OF HEMATOLOGY, 101(3), 213-218, 2015年03月

PRPF8 defects cause missplicing in myeloid malignancies
A. Kurtovic-Kozaric; B. Przychodzen; J. Singh; M. M. Konarska; M. J. Clemente; Z. K. Otrock; M. Nakashima; E. D. Hsi; K. Yoshida; Y. Shiraishi; K. Chiba; H. Tanaka; S. Miyano; S. Ogawa; J. Boultwood; H. Makishima; J. P. Maciejewski; R. A. Padgett
LEUKEMIA, 29(1), 126-136, 2015年01月

Mutations in G protein β subunits promote transformation and kinase inhibitor resistance.
Yoda A; Adelmant G; Tamburini J; Chapuy B; Shindoh N; Yoda Y; Weigert O; Kopp N; Wu SC; Kim SS; Liu H; Tivey T; Christie AL; Elpek KG; Card J; Gritsman K; Gotlib J; Deininger MW; Makishima H; Turley SJ; Javidi-Sharifi N; Maciejewski JP; Jaiswal S; Ebert BL; Rodig SJ; Tyner JW; Marto JA; Weinstock DM; Lane AA
Nature medicine, 21(1), 71-75, 2015年01月

Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria
Wenyi Shen; Michael J. Clemente; Naoko Hosono; Kenichi Yoshida; Bartlomiej Przychodzen; Tetsuichi Yoshizato; Yuichi Shiraishi; Satoru Miyano; Seishi Ogawa; Jaroslaw P. Maciejewski; Hideki Makishima
JOURNAL OF CLINICAL INVESTIGATION, 124(10), 4529-4538, 2014年10月

Genetic alterations of the cohesin complex genes in myeloid malignancies
Swapna Thota; Aaron D. Viny; Hideki Makishima; Barbara Spitzer; Tomas Radivoyevitch; Bartlomiej Przychodzen; Mikkael A. Sekeres; Ross L. Levine; Jaroslaw P. Maciejewski
BLOOD, 124(11), 1790-1798, 2014年09月

Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-κB gene network.
Fang J; Barker B; Bolanos L; Liu X; Jerez A; Makishima H; Christie S; Chen X; Rao DS; Grimes HL; Komurov K; Weirauch MT; Cancelas JA; Maciejewski JP; Starczynowski DT
Cell reports, 8(5), 1328-1338, 2014年09月

[Identification of new leukemogenesis-related genes on chromosome 7 in myeloid neoplasms by next generation sequencing].
Makishima H
[Rinsho ketsueki] The Japanese journal of clinical hematology, 55(7), 751-757, 2014年07月

Recurrent genetic defects on chromosome 7q in myeloid neoplasms
N. Hosono; H. Makishima; A. Jerez; K. Yoshida; B. Przychodzen; S. McMahon; Y. Shiraishi; K. Chiba; H. Tanaka; S. Miyano; M. Sanada; I. Gomez-Segui; A. K. Verma; M. A. McDevitt; M. A. Sekeres; S. Ogawa; J. P. Maciejewski
LEUKEMIA, 28(6), 1348-1351, 2014年06月

Concurrent Juvenile Myelomonocytic Leukemia and T-Lymphoblastic Lymphoma With a Shared Missense Mutation in NRAS
Brenda Ly; Arunkumar Modi; Heesun J. Rogers; Hideki Makishima; Rabi Hanna; James R. Cook; Karl S. Theil; Jaroslaw P. Maciejewski
PEDIATRIC BLOOD & CANCER, 61(5), 946-948, 2014年05月

Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms
F. Traina; V. Visconte; P. Elson; A. Tabarroki; A. M. Jankowska; E. Hasrouni; Y. Sugimoto; H. Szpurka; H. Makishima; C. L. O'Keefe; M. A. Sekeres; A. S. Advani; M. Kalaycio; E. A. Copelan; Y. Saunthararajah; S. T. Olalla Saad; J. P. Maciejewski; R. V. Tiu
LEUKEMIA, 28(1), 78-87, 2014年01月

STAT3 gene mutations and their association with pure red cell aplasia in large granular lymphocyte leukemia
Fumihiro Ishida; Kazuyuki Matsuda; Nodoka Sekiguchi; Hideki Makishima; Chiaki Taira; Kayoko Momose; Sayaka Nishina; Noriko Senoo; Hitoshi Sakai; Toshiro Ito; Yok-Lam Kwong
Cancer Science, 105(3), 342-346, 2014年

Screening Tests Using Serum Tissue Transglutaminase IgA May Facilitate the Identification of Undiagnosed Celiac Disease among Japanese Population
Hideyuki Nakazawa; Hideki Makishima; Toshiro Ito; Hiroyoshi Ota; Kayoko Momose; Nodoka Sekiguchi; Kaname Yoshizawa; Taiji Akamatsu; Fumihiro Ishida
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 11(8), 819-823, 2014年

Granulocyte colony-stimulating factor receptor T595I (T618I) mutation confers ligand independence and enhanced signaling
H. M. Mehta; T. Glaubach; A. Long; H. Lu; B. Przychodzen; H. Makishima; M. A. McDevitt; N. C. P. Cross; J. Maciejewski; S. J. Corey
LEUKEMIA, 27(12), 2407-2410, 2013年12月

CSF3R T618I co-occurs with mutations of splicing and epigenetic genes and with a new PIM3 truncated fusion gene in chronic neutrophilic leukemia
J. Menezes; H. Makishima; I. Gomez; F. Acquadro; G. Gomez-Lopez; O. Grana; A. Dopazo; S. Alvarez; M. Trujillo; D. G. Pisano; J. P. Maciejewski; J. C. Cigudosa
BLOOD CANCER JOURNAL, 3, e158, 2013年11月

STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients.
Jerez A; Clemente MJ; Makishima H; Rajala H; Gómez-Seguí I; Olson T; McGraw K; Przychodzen B; Kulasekararaj A; Afable M; Husseinzadeh HD; Hosono N; LeBlanc F; Lagström S; Zhang D; Ellonen P; Tichelli A; Nissen C; Lichtin AE; Wodnar-Filipowicz A; Mufti GJ; List AF; Mustjoki S; Loughran TP Jr; Maciejewski JP
Blood, 122(14), 2453-2459, 2013年10月

[Deep sequencing].
Makishima H
[Rinsho ketsueki] The Japanese journal of clinical hematology, 54(10), 1559-1565, 2013年10月

Novel recurrent mutations in the RAS-like GTP-binding gene RIT1 in myeloid malignancies
I. Gomez-Segui; H. Makishima; A. Jerez; K. Yoshida; B. Przychodzen; S. Miyano; Y. Shiraishi; H. D. Husseinzadeh; K. Guinta; M. Clemente; N. Hosono; M. A. McDevitt; A. R. Moliterno; M. A. Sekeres; S. Ogawa; J. P. Maciejewski
LEUKEMIA, 27(9), 1943-1946, 2013年09月

SF3B1 mutations are infrequently found in non-myelodysplastic bone marrow failure syndromes and mast cell diseases but, if present, are associated with the ring sideroblast phenotype
Valeria Visconte; Ali Tabarroki; Heesun J. Rogers; Edy Hasrouni; Fabiola Traina; Hideki Makishima; Betty K. Hamilton; Yang Liu; Christine O'Keefe; Alan Lichtin; Leonard Horwitz; Mikkael A. Sekeres; Fred H. Hsieh; Ramon V. Tiu
HAEMATOLOGICA, 98(9), E105-E107, 2013年09月

Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms
Bartlomiej Przychodzen; Andres Jerez; Kathryn Guinta; Mikkael A. Sekeres; Richard Padgett; Jaroslaw P. Maciejewski; Hideki Makishima
BLOOD, 122(6), 999-1006, 2013年08月

Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia
Hirotoshi Sakaguchi; Yusuke Okuno; Hideki Muramatsu; Kenichi Yoshida; Yuichi Shiraishi; Mariko Takahashi; Ayana Kon; Masashi Sanada; Kenichi Chiba; Hiroko Tanaka; Hideki Makishima; Xinan Wang; Yinyan Xu; Sayoko Doisaki; Asahito Hama; Koji Nakanishi; Yoshiyuki Takahashi; Nao Yoshida; Jaroslaw P. Maciejewski; Satoru Miyano; Seishi Ogawa; Seiji Kojima
NATURE GENETICS, 45(8), 937-U140, 2013年08月

Somatic SETBP1 mutations in myeloid malignancies
Hideki Makishima; Kenichi Yoshida; Nhu Nguyen; Bartlomiej Przychodzen; Masashi Sanada; Yusuke Okuno; Kwok Peng Ng; Kristbjorn O. Gudmundsson; Bandana A. Vishwakarma; Andres Jerez; Ines Gomez-Segui; Mariko Takahashi; Yuichi Shiraishi; Yasunobu Nagata; Kathryn Guinta; Hiraku Mori; Mikkael A. Sekeres; Kenichi Chiba; Hiroko Tanaka; Hideki Muramatsu; Hirotoshi Sakaguchi; Ronald L. Paquette; Michael A. McDevitt; Seiji Kojima; Yogen Saunthararajah; Satoru Miyano; Lee-Yung Shih; Yang Du; Seishi Ogawa; Jaroslaw P. Maciejewski
NATURE GENETICS, 45(8), 942-U298, 2013年08月

Multiple mechanisms deregulate EZH2 and histone H3 lysine 27 epigenetic changes in myeloid malignancies.
Khan SN; Jankowska AM; Mahfouz R; Dunbar AJ; Sugimoto Y; Hosono N; Hu Z; Cheriyath V; Vatolin S; Przychodzen B; Reu FJ; Saunthararajah Y; O'Keefe C; Sekeres MA; List AF; Moliterno AR; McDevitt MA; Maciejewski JP; Makishima H
Leukemia, 27(6), 1301-1309, 2013年06月

Naive T-cells in myelodysplastic syndrome display intrinsic human telomerase reverse transcriptase (hTERT) deficiency
L. Yang; A. Mailloux; D. E. Rollison; J. S. Painter; J. Maciejewski; R. L. Paquette; T. P. Loughran; K. McGraw; H. Makishima; R. Radhakrishnan; S. Wei; X. Ren; R. Komrokji; A. F. List; P. K. Epling-Burnette
LEUKEMIA, 27(4), 897-906, 2013年04月

Spliceosomal gene mutations are frequent events in the diverse mutational spectrum of chronic myelomonocytic leukemia but largely absent in juvenile myelomonocytic leukemia
Sarah Abu Kar; Anna Jankowska; Hideki Makishima; Valeria Visconte; Andres Jerez; Yuka Sugimoto; Hideki Muramatsu; Fabiola Traina; Manuel Afable; Kathryn Guinta; Ramon V. Tiu; Bartlomiej Przychodzen; Hirotoshi Sakaguchi; Seiji Kojima; Mikkael A. Sekeres; Alan F. List; Michael A. McDevitt; Jaroslaw P. Maciejewski
Haematologica, 98(1), 107-113, 2013年01月

Emerging roles of the spliceosomal machinery in myelodysplastic syndromes and other hematological disorders
V. Visconte; H. Makishima; J. P. Maciejewski; R. V. Tiu
LEUKEMIA, 26(12), 2447-2454, 2012年12月

Mutational analysis of RNA splicing machinery components in 206 children with myeloid malignancies
Hirotoshi Sakaguchi; Hideki Makishima; Hideki Muramatsu; Valeria Visconte; Andres Jerez; Anna M. Jankowska; Ramon V. Tiu; Jaroslaw P. Maciejewski; Seiji Kojima
LEUKEMIA RESEARCH, 36(12), E215-E217, 2012年12月

Phase 2 study of the lenalidomide and azacitidine combination in patients with higher-risk myelodysplastic syndromes
Mikkael A. Sekeres; Ramon V. Tiu; Rami Komrokji; Jeffrey Lancet; Anjali S. Advani; Manuel Afable; Ricki Englehaupt; Joyce Juersivich; David Cuthbertson; Jennifer Paleveda; Ali Tabarroki; Valeria Visconte; Hideki Makishima; Andres Jerez; Ronald Paquette; Alan F. List; Jaroslaw P. Maciejewski
BLOOD, 120(25), 4945-4951, 2012年12月

SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes
Valeria Visconte; Heesun J. Rogers; Jarnail Singh; John Barnard; Manoj Bupathi; Fabiola Traina; James McMahon; Hideki Makishima; Hadrian Szpurka; Anna Jankowska; Andres Jerez; Mikkael A. Sekeres; Yogen Saunthararajah; Anjali S. Advani; Edward Copelan; Haruhiko Koseki; Kyoichi Isono; Richard A. Padgett; Sami Osman; Kazunori Koide; Christine O'Keefe; Jaroslaw P. Maciejewski; Ramon V. Tiu
BLOOD, 120(16), 3173-3186, 2012年10月

STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia
Andres Jerez; Michael J. Clemente; Hideki Makishima; Hanna Koskela; Francis LeBlanc; Kwok Peng Ng; Thomas Olson; Bartlomiej Przychodzen; Manuel Afable; Ines Gomez-Segui; Kathryn Guinta; Lisa Durkin; Eric D. Hsi; Kathy McGraw; Dan Zhang; Marcin W. Wlodarski; Kimmo Porkka; Mikkael A. Sekeres; Alan List; Satu Mustjoki; Thomas P. Loughran; Jaroslaw P. Maciejewski
BLOOD, 120(15), 3048-3057, 2012年10月

Casitas B-cell lymphoma mutation in childhood T-cell acute lymphoblastic leukemia.
Yuka Saito; Yoko Aoki; Hideki Muramatsu; Hideki Makishima; Jaroslaw P Maciejewski; Masue Imaizumi; Takeshi Rikiishi; Yoji Sasahara; Shigeo Kure; Tetsuya Niihori; Shigeru Tsuchiya; Seiji Kojima; Yoichi Matsubara
Leukemia research, 36(8), 1009-15, 2012年08月

Single Nucleotide Polymorphism Array Lesions, TET2, DNMT3A, ASXL1 and CBL Mutations Are Present in Systemic Mastocytosis
Fabiola Traina; Valeria Visconte; Anna M. Jankowska; Hideki Makishima; Christine L. O'Keefe; Paul Elson; Yingchun Han; Fred H. Hsieh; Mikkael A. Sekeres; Raghuveer Singh Mali; Matt Kalaycio; Alan E. Lichtin; Anjali S. Advani; Hien K. Duong; Edward Copelan; Reuben Kapur; Sara T. Olalla Saad; Jaroslaw P. Maciejewski; Ramon V. Tiu
PLOS ONE, 7(8), e43090, 2012年08月

CBL mutation-related patterns of phosphorylation and sensitivity to tyrosine kinase inhibitors
H. Makishima; Y. Sugimoto; H. Szpurka; M. J. Clemente; K. P. Ng; H. Muramatsu; C. O'Keefe; Y. Saunthararajah; J. P. Maciejewski
LEUKEMIA, 26(7), 1547-1554, 2012年07月

Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis
Andres Jerez; Yuka Sugimoto; Hideki Makishima; Amit Verma; Anna M. Jankowska; Bartlomiej Przychodzen; Valeria Visconte; Ramon V. Tiu; Christine L. O'Keefe; Azim M. Mohamedali; Austin G. Kulasekararaj; Andrea Pellagatti; Kathy McGraw; Hideki Muramatsu; Alison R. Moliterno; Mikkael A. Sekeres; Michael A. McDevitt; Seiji Kojima; Alan List; Jacqueline Boultwood; Ghulam J. Mufti; Jaroslaw P. Maciejewski
BLOOD, 119(25), 6109-6117, 2012年06月

Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis
Hideki Makishima; Valeria Visconte; Hirotoshi Sakaguchi; Anna M. Jankowska; Sarah Abu Kar; Andres Jerez; Bartlomiej Przychodzen; Manoj Bupathi; Kathryn Guinta; Manuel G. Afable; Mikkael A. Sekeres; Richard A. Padgett; Ramon V. Tiu; Jaroslaw P. Maciejewski
BLOOD, 119(14), 3203-3210, 2012年04月

Topography, Clinical, and Genomic Correlates of 5q Myeloid Malignancies Revisited
Andres Jerez; Lukasz P. Gondek; Anna M. Jankowska; Hideki Makishima; Bartlomiej Przychodzen; Ramon V. Tiu; Christine L. O'Keefe; Azim M. Mohamedali; Denise Batista; Mikkael A. Sekeres; Michael A. McDevitt; Ghulam J. Mufti; Jaroslaw P. Maciejewski
JOURNAL OF CLINICAL ONCOLOGY, 30(12), 1343-1349, 2012年04月

SF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblasts
V. Visconte; H. Makishima; A. Jankowska; H. Szpurka; F. Traina; A. Jerez; C. O'Keefe; H. J. Rogers; M. A. Sekeres; J. P. Maciejewski; R. V. Tiu
LEUKEMIA, 26(3), 542-545, 2012年03月

Cytogenetic and molecular predictors of response in patients with myeloid malignancies without del[5q] treated with lenalidomide
Yuka Sugimoto; Mikkael A. Sekeres; Hideki Makishima; Fabiola Traina; Valeria Visconte; Anna Jankowska; Andres Jerez; Hadrian Szpurka; Christine L. O'Keefe; Kathryn Guinta; Manuel Afable; Ramon Tiu; Kathy L. McGraw; Alan F. List; Jaroslaw Maciejewski
JOURNAL OF HEMATOLOGY & ONCOLOGY, 5, 4, 2012年03月

Molecular lesions in childhood and adult acute megakaryoblastic leukaemia
Asahito Hama; Hideki Muramatsu; Hideki Makishima; Yuka Sugimoto; Hadrian Szpurka; Monika Jasek; Christine O'Keefe; Yoshiyuki Takahashi; Hirotoshi Sakaguchi; Sayoko Doisaki; Akira Shimada; Nobuhiro Watanabe; Koji Kato; Hitoshi Kiyoi; Tomoki Naoe; Seiji Kojima; Jaroslaw P. Maciejewski
BRITISH JOURNAL OF HAEMATOLOGY, 156(3), 316-325, 2012年02月

Chronic Myelomonocytic Leukemia and Atypical Chronic Myeloid Leukemia: Novel Pathogenetic Lesions
Hideki Muramatsu; Hideki Makishima; Jaroslaw P. Maciejewski
SEMINARS IN ONCOLOGY, 39(1), 67-73, 2012年02月

Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A
Anna M. Jankowska; Hideki Makishima; Ramon V. Tiu; Hadrian Szpurka; Yun Huang; Fabiola Traina; Valeria Visconte; Yuka Sugimoto; Courtney Prince; Christine O'Keefe; Eric D. Hsi; Alan List; Mikkael A. Sekeres; Anjana Rao; Michael A. McDevitt; Jaroslaw P. Maciejewski
BLOOD, 118(14), 3932-3941, 2011年10月

Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia
Michael J. Clemente; Marcin W. Wlodarski; Hideki Makishima; Aaron D. Viny; Isabell Bretschneider; Mohammad Shaik; Nelli Bejanyan; Alan E. Lichtin; Eric D. His; Ronald L. Paquette; Thomas P. Loughran; Jaroslaw P. Maciejewski
BLOOD, 118(16), 4384-4393, 2011年10月

Donor lymphocyte infusion for extranodal NK/T cell lymphoma, nasal type, relapsed after allogeneic hematopoietic SCT
T. Ito; H. Makishima; H. Nakazawa; Y. Senoo; N. Senoo; F. Ishida
BONE MARROW TRANSPLANTATION, 46(9), 1270-1271, 2011年09月

Predictions in the Face of Clinical Reality: HistoCheck versus High-Risk HLA Allele Mismatch Combinations Responsible for Severe Acute Graft-versus-Host Disease
Medhat Askar; Ronald Sobecks; Yasuo Morishima; Takakazu Kawase; Amy Nowacki; Hideki Makishima; Jaroslaw Maciejewski
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 17(9), 1409-1415, 2011年09月

Efficacy of rabbit anti-thymocyte globulin in severe aplastic anemia
Manuel G. Afable; Mohammed Shaik; Yuka Sugimoto; Paul Elson; Michael Clemente; Hideki Makishima; Mikkael A. Sekeres; Alan Lichtin; Anjali Advani; Matt Kalaycio; Ramon V. Tiu; Christine L. O'Keefe; Jaroslaw P. Maciejewski
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 96(9), 1269-1275, 2011年09月

Pathogenesis and Consequences of Uniparental Disomy in Cancer
Hideki Makishima; Jaroslaw P. Maciejewski
CLINICAL CANCER RESEARCH, 17(12), 3913-3923, 2011年06月

SNP array-based karyotyping: differences and similarities between aplastic anemia and hypocellular myelodysplastic syndromes
Manuel G. Afable; Marcin Wlodarski; Hideki Makishima; Mohammed Shaik; Mikkael A. Sekeres; Ramon V. Tiu; Matt Kalaycio; Christine L. O'Keefe; Jaroslaw P. Maciejewski
BLOOD, 117(25), 6876-6884, 2011年06月

CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia
Hideki Makishima; Anna M. Jankowska; Michael A. McDevitt; Christine O' Keefe; Simon Dujardin; Heather Cazzolli; Bartlomiej Przychodzen; Courtney Prince; John Nicoll; Harish Siddaiah; Mohammed Shaik; Hadrian Szpurka; Eric Hsi; Anjali Advani; Ronald Paquette; Jaroslaw P. Maciejewski
BLOOD, 117(21), E198-E206, 2011年05月

Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies
H. Makishima; A. M. Jankowska; R. V. Tiu; H. Szpurka; Y. Sugimoto; Z. Hu; Y. Saunthararajah; K. Guinta; M. A. Keddache; P. Putnam; M. A. Sekeres; A. R. Moliterno; A. F. List; M. A. McDevitt; J. P. Maciejewski
LEUKEMIA, 24(10), 1799-1804, 2010年10月

Spectrum of mutations in RARS-T patients includes TET2 and ASXL1 mutations
Hadrian Szpurka; Anna M. Jankowska; Hideki Makishima; Juraj Bodo; Nelli Bejanyan; Eric D. Hsi; Mikkael A. Sekeres; Jaroslaw P. Maciejewski
LEUKEMIA RESEARCH, 34(8), 969-973, 2010年08月

Killer cell immunoglobulin-like receptor gene polymorphism in lymphoproliferative diseases of granular lymphocytes in a Japanese population
Kosuke Obama; Hideki Makishima; Fumihiro Ishida
LEUKEMIA & LYMPHOMA, 51(8), 1580-1581, 2010年08月

Spectrum of molecular defects in juvenile myelomonocytic leukaemia includes ASXL1 mutations
Yuka Sugimoto; Hideki Muramatsu; Hideki Makishima; Courtney Prince; Anna M. Jankowska; Nao Yoshida; Yinyan Xu; Nobuhiro Nishio; Asahito Hama; Hiroshi Yagasaki; Yoshiyuki Takahashi; Koji Kato; Atsushi Manabe; Seiji Kojima; Jaroslaw P. Maciejewski
BRITISH JOURNAL OF HAEMATOLOGY, 150(1), 83-87, 2010年07月

FISH and SNP-A karyotyping in myelodysplastic syndromes: Improving cytogenetic detection of del(5q), monosomy 7, del(7q), trisomy 8 and del(20q)
Hideki Makishima; Manjot Rataul; Lukasz P. Gondek; Jungwon Huh; James R. Cook; Karl S. Theil; Mikkael A. Sekeres; Elizabeth Kuczkowski; Christine O' Keefe; Jaroslaw P. Maciejewski
LEUKEMIA RESEARCH, 34(4), 447-453, 2010年04月

Characterization of Chromosome Arm 20q Abnormalities in Myeloid Malignancies Using Genome-Wide Single Nucleotide Polymorphism Array Analysis
Jungwon Huh; Ramon V. Tiu; Lukasz P. Gondek; Christine L. O'Keefe; Monika Jasek; Hideki Makishima; Ania M. Jankowska; Ying Jiang; Amit Verma; Karl S. Theil; Michael A. McDevitt; Jaroslaw P. Maciejewski
GENES CHROMOSOMES & CANCER, 49(4), 390-399, 2010年04月

Mutations of an E3 ubiquitin ligase c-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia
Hideki Muramatsu; Hideki Makishima; Anna M. Jankowska; Heather Cazzolli; Christine O' Keefe; Nao Yoshida; Yinyan Xu; Nobuhiro Nishio; Asahito Hama; Hiroshi Yagasaki; Yoshiyuki Takahashi; Koji Kato; Atsushi Manabe; Seiji Kojima; Jaroslaw P. Maciejewski
BLOOD, 115(10), 1969-1975, 2010年03月

Mutations of E3 Ubiquitin Ligase Cbl Family Members Constitute a Novel Common Pathogenic Lesion in Myeloid Malignancies
Hideki Makishima; Heather Cazzolli; Hadrian Szpurka; Andrew Dunbar; Ramon Tiu; Jungwon Huh; Hideki Muramatsu; Christine O' Keefe; Eric Hsi; Ronald L. Paquette; Seiji Kojima; Alan F. List; Mikkael A. Sekeres; Michael A. McDevitt; Jaroslaw P. Maciejewski
JOURNAL OF CLINICAL ONCOLOGY, 27(36), 6109-6116, 2009年12月

Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms
Anna M. Jankowska; Hadrian Szpurka; Ramon V. Tiu; Hideki Makishima; Manuel Afable; Jungwon Huh; Christine L. O'Keefe; Rebecca Ganetzky; Michael A. McDevitt; Jaroslaw P. Maciejewski
BLOOD, 113(25), 6403-6410, 2009年06月

250K Single Nucleotide Polymorphism Array Karyotyping Identifies Acquired Uniparental Disomy and Homozygous Mutations, Including Novel Missense Substitutions of c-Cbl, in Myeloid Malignancies
Andrew J. Dunbar; Lukasz P. Gondek; Christine L. O'Keefe; Hideki Makishima; Manjot S. Rataul; Hadrian Szpurka; Mikkael A. Sekeres; Xiao Fei Wang; Michael A. McDevitt; Jaroslaw P. Maciejewski
CANCER RESEARCH, 68(24), 10349-10357, 2008年12月

Promising approach for aggressive NK cell leukaemia with allogeneic haematopoietic cell transplantation
Toshiro Ito; Hideki Makishima; Hideyuki Nakazawa; Hikaru Kobayashi; Shigetaka Shimodaira; Yozo Nakazawa; Kiyoshi Kitano; Kazuyuki Matsuda; Eiko Hidaka; Fumihiro Ishida
EUROPEAN JOURNAL OF HAEMATOLOGY, 81(2), 107-111, 2008年08月

[Analysis of chemokine receptor expression in aggressive NK-cell leukemia and chronic NK-cell lymphocytosis].
Makishima H
[Rinsho ketsueki] The Japanese journal of clinical hematology, 49(1), 3-9, 2008年01月

Peripheral T-cell lymphoma following diffuse large B-cell lymphoma associated with celiac disease
Hideki Makishima; Yuichi Komiyama; Naoko Asano; Kayoko Momose; Shigeo Nakamura; Fumihiro Ishida
INTERNAL MEDICINE, 47(4), 295-298, 2008年

Chemokine system and tissue infiltration in aggressive NK-cell leukemia
Hideki Makishima; Toshiro Ito; Kayoko Momose; Hideyuki Nakazawa; Shigetaka Shimodaira; Yuji Kamijo; Yozo Nakazawa; Naoaki Ichikawa; Mayumi Ueno; Hikaru Kobayashi; Kiyoshi Kitano; Hiroshi Saito; Kendo Kiyosawa; Fumihiro Ishida
LEUKEMIA RESEARCH, 31(9), 1237-1245, 2007年09月

Close resemblance between chemokine receptor expression profiles of lymphoproliferative disease of granular lymphocytes and their normal counterparts in association with elevated serum concentrations of IP-10 and MIG
Kayoko Momose; Hideki Makishima; Toshiro Ito; Hideyuki Nakazawa; Shigetaka Shimodaira; Kendo Kiyosawa; Fumihiro Ishida
INTERNATIONAL JOURNAL OF HEMATOLOGY, 86(2), 174-179, 2007年08月

A case of acute myelogenous leukemia with MLL-AF10 fusion caused by insertion of 5 ' MLL into 10p12, with concurrent 3 ' MLL deletion
Kazuyuki Matsuda; Eiko Hidaka; Futnihiro Ishida; Kazuyoshi Yamauchi; Hideki Makishima; Toshiro Ito; Takefumi Suzuki; Eri Imagawa; Kenji Sano; Tsutomu Katsuyama; Hiroyoshi Ota
CANCER GENETICS AND CYTOGENETICS, 171(1), 24-30, 2006年11月

Intestinal diffuse large B-cell lymphoma associated with celiac disease: A Japanese case
H Makishima; T Ito; R Kodama; N Asano; H Nakazawa; K Hirabayashi; S Nakamura; M Ota; T Akamatsu; K Kiyosawa; F Ishida
INTERNATIONAL JOURNAL OF HEMATOLOGY, 83(1), 63-65, 2006年01月

Adenovirus fulminant hepatic failure: Disseminated adenovirus disease after unrelated allogeneic stem cell transplantation for acute lymphoblastic leukemia
Hideyuki Nakazawa; Toshiro Ito; Hideki Makishima; Noriko Misawa; Wataru Okiyama; Takeshi Uehara; Eiko Hidaka; Kendo Kiyosawa; Fumihiro Ishida
INTERNAL MEDICINE, 45(16), 975-980, 2006年

Retroviral expression screening of oncogenes in natural killer cell leukemia
YL Choi; R Moriuchi; M Osawa; A Iwama; H Makishima; T Wada; H Kisanuki; R Kaneda; J Ota; K Koinuma; M Ishikawa; S Takada; Y Yamashita; K Oshimi; H Mano
LEUKEMIA RESEARCH, 29(8), 943-949, 2005年08月

Significance of chemokine receptor expression in aggressive NK cell leukemia
H Makishima; T Ito; N Asano; H Nakazawa; S Shimodaira; Y Kamijo; Y Nakazawa; T Suzuki; H Kobayashi; K Kiyosawa; F Ishida
LEUKEMIA, 19(7), 1169-1174, 2005年07月

DNA microarray analysis of natural killer cell-type lymphoproliferative disease of granular lymphocytes with purified CD3(-)CD56(+) fractions
YL Choi; H Makishima; J Ohashi; Y Yamashita; R Ohki; K Koinuma; J Ota; Y Isobe; F Ishida; K Oshimi; H Mano
LEUKEMIA, 18(3), 556-565, 2004年03月

In vivo stabilization of nuclear retinoid X receptor alpha in the presence of peroxisome proliferator-activated receptor alpha
N Tanaka; K Hora; H Makishima; Y Kamijo; K Kiyosawa; FJ Gonzalez; T Aoyama
FEBS LETTERS, 543(1-3), 120-124, 2003年05月

Lymphoproliferative disease of granular lymphocytes with T-cell receptor gamma delta-positive phenotype: restricted usage of T-cell receptor gamma and delta subunit genes
H Makishima; F Ishida; H Saito; N Ichikawa; Y Ozaki; S Ito; M Ota; Y Katsuyama; K Kiyosawa
EUROPEAN JOURNAL OF HAEMATOLOGY, 70(4), 212-218, 2003年04月

DNA microarray analysis of T cell-type lymphoproliferative disease of granular lymphocytes
H Makishima; F Ishida; T Ito; K Kitano; S Ueno; K Ohmine; Y Yamashita; J Ota; M Ota; K Yamauchi; H Mano
BRITISH JOURNAL OF HAEMATOLOGY, 118(2), 462-469, 2002年08月

t(8;21;14)(q22;q22;q24) is a novel variant of t(8;21) with chimeric transcripts of AML1-ETO in acute myelogenous leukemia
F Ishida; M Ueno; H Tanaka; H Makishima; K Suzawa; S Hosaka; E Hidaka; M Ishikawa; K Yamauchi; K Kitano; K Kiyosawa
CANCER GENETICS AND CYTOGENETICS, 132(2), 133-135, 2002年01月

A case of acute idiopathic thrombocytopenic purpura during pregnancy successfully treated with high-dose γ-globulin and prednisolone
H. Makishima; K. Kitano; F. Ishida; K. Kiyosawa; T. Mochizuki; K. Hayashi
Shinshu Medical Journal, 47(4), 309-314, 1999年

A case of primary cardiac lymphoma: Utility of serum soluble interleukin-2 receptor for noninvasive diagnosis
H Makishima; M Isobe; H Imamura
INTERNATIONAL JOURNAL OF CARDIOLOGY, 65(3), 291-293, 1998年08月

後天性赤芽球癆におけるリンパ性、骨髄性クローン性造血関連遺伝子変異
川上 徹; 川上 史裕; 松澤 周治; 山根 拓; 水野 裕雅; 朝倉 亜美; 氷鉋 大悟; 宮入 翔太郎; 酒井 香生子; 仁科 さやか; 酒井 均; 久保田 寧; 樋口 由美子; 牧島 秀樹; 中澤 英之; 石田 文宏
日本血液学会学術集会, 86回, O2-6, 2024年10月

DDX41変異
牧島 秀樹
臨床血液, 65(4), 309-309, 2024年04月

クローン性造血と新型コロナ感染症重症化リスクの関連性
佐伯 龍之介; 枝廣 龍哉; 曽根原 究人; 王 青波; 南宮 湖; 田中 拓; 阿瀬川 周平; 中鉢 正太郎; 難波 真一; 山本 賢一; 垣内 伸之; 白石 友一; 千葉 健一; 田中 洋子; 牧島 秀樹; 南谷 泰仁; 小池 竜司; 高野 友美; 石井 誠; 木村 彰方; 井元 清哉; 宮野 悟; 金井 隆典; 福永 興壱; 岡田 随象; 小川 誠司
日本血液学会学術集会, 85回, 51-51, 2023年10月

クローン性造血をめぐる最近の知見と話題 クローン性造血と再生不良性貧血
牧島秀樹
月刊血液内科, 86(1), 49-55, 2023年

再生不良性貧血・発作性夜間血色素尿症に潜むクローン性造血
牧島 秀樹
臨床血液, 63(9), 1042-1045, 2022年09月

Amplified EPOR/JAK2 genes definea unique subtype of acute erythroid leukemia.
June Takeda; Kenichi Yoshida; Masahiro M. Nakagawa; Yasuhito Nannya; Akinori Yoda; Ryunosuke Saiki; Yotaro Ochi; Lanying Zhao; Rurika Okuda; Xingxing Qi; Takuto Mori; Ayana Kon; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Ming-Chung Kuo; Cassandra Kerr; Yasunobu Nagata; Daisuke Morishita; Nobuhiro Hiramoto; Akira Hangaishi; Hideyuki Nakazawa; Ken Ishiyama; Satoru Miyano; Shigeru Chiba; Yasushi Miyazaki; Toshiyuki Kitano; Kensuke Usuki; Nobuo Sezaki; Hisashi Tsurumi; Shuichi Miyawaki; Jaroslaw P. Maciejewski; Takayuki Ishikawa; Kazuma Ohyashiki; Arnold Ganser; Michael Heuser; Felicitas Thol; Lee-Yung Shih; Akifumi Takaori-Kondo; Hideki Makishima; Seishi Ogawa
CANCER RESEARCH, 82(12), 2022年06月

EPOR/JAK/STAT Signaling Pathway As Therapeutic Target of Acute Erythroid Leukemia
June Takeda; Kenichi Yoshida; Masahiro Marshall Nakagawa; Yasuhito Nannya; Akinori Yoda; Daisuke Morishita; Ryunosuke Saiki; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Ming-Chung Kuo; Cassandra M. Kerr; Yasunobu Nagata; Nobuhiro Hiramoto; Akira Hangaishi; Hideyuki Nakazawa; Ken Ishiyama; Satoru Miyano; Shigeru Chiba; Yasushi Miyazaki; Toshiyuki Kitano; Kensuke Usuki; Nobuo Sezaki; Hisashi Tsurumi; Shuichi Miyawaki; Jaroslaw P. Maciejewski; Takayuki Ishikawa; Kazuma Ohyashiki; Arnold Ganser; Michael Heuser; Felicitas Thol; Lee-Yung Shih; Akifumi Takaori-Kondo; Hideki Makishima; Seishi Ogawa
BLOOD, 138, 2021年11月

The functional role of compound DDX41 germline and somatic R525H mutations in the development of myeloid neoplasms
Ayana Kon; Masahiro Nakagawa; Ryosaku Inagaki; Keisuke Kataoka; Yotaro Ochi; Hideki Makishima; Manabu Nakayama; Haruhiko Koseki; Yasuhito Nannya; Seishi Ogawa
CANCER SCIENCE, 112, 454-454, 2021年02月

Early Clonal evolution of myeloid malignancies
Masahiro Nakagawa; Ryosaku Inagaki; Yasuhito Nannya; Lanying Zhao; Yotaro Ochi; June Takeda; Xingxing Qi; Akinori Yoda; Ayana Kon; Nobuyuki Kakiuchi; Hideki Makishima; Shinichi Matsuda; Seishi Ogawa
CANCER SCIENCE, 112, 969-969, 2021年02月

Genetic profiling and prognosis of blast crisis in chronic myeloid leukemia
Yotaro Ochi; Kenichi Yoshida; Ko Sasaki; Noriko Hosoya; Yusuke Shiozawa; Yasuhito Nannya; Takayuki Ishikawa; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Hideki Makishima; Akifumi Takaori-Kondo; Satoru Miyano; Kinuko Mitani; Seishi Ogawa
CANCER SCIENCE, 112, 454-454, 2021年02月

Distinct ethnic, clinical, and genetic characteristics of der(1;7) in myelodysplastic syndromes.
Rurika Okuda; Yasuhito Nannya; Yotaro Ochi; Kazuhisa Chonabayashi; Maria Creignou; Hideki Makishima; June Takeda; Ayana Kon; Satoru Miyano; Hiroshi Handa; Shigeru Chiba; Kazuma Ohyashiki; Torsten Haferlach; Eva Lindberg; Seishi Ogawa
CANCER SCIENCE, 112, 310-310, 2021年02月

JAK STAT Pathway is a Promising Therapeutic target in Acute Erythroid Leukemia
June Takeda; Kenichi Yoshida; Akinori Yoda; Yasuhito Nannya; Masahiro Nakagawa; Yotaro Ochi; Ayana Kon; Tetsuichi Yoshizato; Yusuke Shiozawa; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Satoru Miyano; Hideki Makishima; Seishi Ogawa
CANCER SCIENCE, 112, 453-453, 2021年02月

CTX-712, a novel CLK inhibitor targeting myeloid neoplasms with SRSF2 mutation
Akinori Yoda; Daisuke Morishita; Akio Mizutani; Yotaro Ochi; Hirokazu Tozaki; Yoshihiko Satoh; June Takeda; Yasuhito Nannya; Hideki Makishima; Hiroshi Miyake; Seishi Ogawa
CANCER SCIENCE, 112, 250-250, 2021年02月

Frequent abnormalities in TP53 and increased genetic instability in myxofibrosarcoma
Yasuhide Takeuchi; Hiromichi Suzuki; Kenichi Yoshida; Yuichi Shiraishi; Nobuyuki Kakiuchi; Yusuke Shiozawa; Yoshikage Inoue; Kenichi Chiba; Hideki Makishima; Satoru Miyano; Hironori Haga; Frederik Damm; Seishi Ogawa
CANCER SCIENCE, 112, 850-850, 2021年02月

DDX41変異骨髄腫瘍の分子病因【JST・京大機械翻訳】|||
昆彩奈; 中川正宏; 片岡圭亮; 片岡圭亮; 稲垣良作; 牧島秀樹; 越智陽太郎; 中山学; 古関明彦; 南谷泰仁; 小川誠司
日本血液学会学術集会抄録(Web), 83rd, 2021年

ETNK1変異は骨髄異形成症候群におけるder(1;7)(q10;p10)のサブクラスを規定する【JST・京大機械翻訳】|||
奥田瑠璃花; 南谷泰人; 越智陽太郎; 蝶名林和久; 蝶名林和久; 牧島秀樹; 吉里哲一; 永田安伸; 竹田淳恵; 吉田健一; 眞田昌; 眞田昌; 昆彩奈; 白石雄一; 宮野悟; 熱田由子; 笠原千嗣; 半田寛; 千葉滋; 大屋敷一馬; 吉田善紀; 小川誠司; 小川誠司; 小川誠司
日本血液学会学術集会抄録(Web), 83rd, 2021年

骨髄系腫瘍におけるDDX41胚細胞変異・体細胞変異の分子病態の解明
昆彩奈; 中川正宏; 片岡圭亮; 片岡圭亮; 稲垣良作; 牧島秀樹; 越智陽太郎; 中山学; 古関明彦; 南谷泰仁; 小川誠司
日本癌学会学術総会抄録集(Web), 80th, 2021年

ETNK1変異の有無を特徴とするder(1;7)(q10;p10)を伴う骨髄異形成症候群
奥田瑠璃花; 南谷泰仁; 越智陽太郎; 蝶名林和久; 蝶名林和久; 牧島秀樹; 永田安伸; 真田昌; 白石友一; 宮野悟; 宮野悟; 熱田由子; 笠原千嗣; 半田寛; 千葉滋; 大屋敷一馬; 小川誠司; 小川誠司; 小川誠司
日本癌学会学術総会抄録集(Web), 80th, 2021年

変異と発現のマルチオミクス単一細胞解析によって明らかにされたクローン造血における初期変異細胞の有する非細胞自律性作用
中川正宏; 稲垣良作; 南谷泰仁; 趙蘭英; 趙蘭英; 越智陽太郎; 竹田淳恵; 戚星星; 依田成玄; 昆彩奈; 吉里哲一; 垣内伸之; 牧島秀樹; 松田秀一; 小川誠司; 小川誠司; 小川誠司
日本癌学会学術総会抄録集(Web), 80th, 2021年

クローン性造血における遺伝子変異とコピー数異常の統合解析
佐伯龍之介; 桃沢幸秀; 南谷泰仁; 中川正宏; 中川正宏; 越智陽太郎; 吉里哲一; 白石友一; 田中洋子; 新井田厚司; 井元清哉; 松田浩一; 村上善則; 松田秀一; 宮野悟; 牧島秀樹; 小川誠司; 小川誠司; 小川誠司
日本癌学会学術総会抄録集(Web), 80th, 2021年

赤白血病におけるゲノム解析と治療標的の検討
竹田淳恵; 吉田健一; 依田成玄; 南谷泰仁; 越智陽太郎; 中川正宏; 佐伯龍之介; 白石友一; 永田安伸; 高折晃史; 千葉滋; 片岡圭亮; 宮野悟; 牧島秀樹; 小川誠司; 小川誠司; 小川誠司
日本癌学会学術総会抄録集(Web), 80th, 2021年

Post-Treatment Clone Size Predicts Survival Independently of IPSS-R and Response after Azacitidine Therapy for MDS
Yasuhito Nannya; Magnus Tobiasson; Shinya Sato; Elsa Bernard; Maria Creignou; Lanying Zhao; June Takeda; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Hisashi Tsurumi; Senji Kasahara; Masataka Taguchi; Akifumi Kondo Takaori; Kazuma Ohyashiki; Hideki Makishima; Kenichi Yoshida; Tomoki Naoe; Satoru Miyano; Yasushi Miyazaki; Elli Papaemmanuil; Eva Hellstrom Lindberg; Seishi Ogawa
BLOOD, 136, 2020年11月

Functional Characterization of Compound DDX41 Germline and Somatic R525H Mutations in the Development of Myeloid Malignancies
Ayana Kon; Masahiro Marshall Nakagawa; Ryosaku Inagaki; Keisuke Kataoka; Hideki Makishima; Yotaro Ochi; Manabu Nakayama; Haruhiko Koseki; Yasuhito Nannya; Seishi Ogawa
BLOOD, 136, 2020年11月

DDX41変異陽性骨髄性腫瘍の臨床的特徴
牧島秀樹
日本癌学会学術総会抄録集(Web), 136, 2020年11月

Distinct Pathogenesis of Clonal Hematopoiesis Revealed By Single Cell RNA Sequencing Integrated with Highly Sensitive Genotyping Method
Masahiro Marshall Nakagawa; Ryosaku Inagaki; Yutaka Kuroda; Yasuhito Nannya; Lanying Zhao; Yotaro Ochi; June Takeda; Qi Xingxing; Akinori Yoda; Ayana Kon; Nobuyuki Kakiuchi; Hideki Makishima; Shuichi Matsuda; Seishi Ogawa
BLOOD, 136, 2020年11月

Genotype-Phenotype Relationships and Therapeutic Targets in Acute Erythroid Leukemia
June Takeda; Kenichi Yoshida; Akinori Yoda; Lee-Yung Shih; Yasuhito Nannya; Yotaro Ochi; Ayana Kon; Kenichi Chiba; Yuichi Shiraishi; Yusuke Shiozawa; Tetsuichi Yoshizato; Cassandra M. Kerr; Yasunobu Nagata; Toshiyuki Kitano; Akira Hangaishi; Ken Ishiyama; Hisashi Tsurumi; Yasushi Miyazaki; Nobuhiro Hiramoto; Takayuki Ishikawa; Masahiro Marshall Nakagawa; Akifumi Takaori-Kondo; Shigeru Chiba; Hideyuki Nakazawa; Ming-Chung Kuo; Keisuke Kataoka; Ryunosuke Saiki; Hiroko Tanaka; Kensuke Usuki; Shuichi Miyawaki; Satoru Miyano; Jaroslaw P. Maciejewski; Arnold Ganser; Michael Heuser; Felicitas Thol; Hideki Makishima; Seishi Ogawa
BLOOD, 136, 2020年11月

Genetic analysis of metachronous pancreatic cancers
Hirano Tomonori; Nobuyuki Kakiuchi; Yasuhide Takeuchi; Yoshikage Inoue; Tomomi Nishimura; Yoichi Fujii; Akira Yokoyama; Hideki Makishima; Toshihiko Masui; Shinji Uemoto; Sachiko Minamiguchi; Hironori Haga; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Satoru Miyano; Norimitsu Uza; Yuzo Kodama; Hiroshi Seno; Seishi Ogawa
CANCER RESEARCH, 80(16), 2020年08月

急性赤白血病に対するJAK-STATパスウェイ阻害薬の有用性の検討
竹田淳恵; 吉田健一; 依田成玄; 南谷泰仁; SHIH Leeyung; 越智陽太郎; 白石友一; KERR Cassandra; 永田安伸; 北野俊行; 半下石明; 石山謙; 鶴見寿; 宮崎泰司; 平本展大; 石川隆之; 中川正宏; 高折晃史; 千葉滋; 中澤英之; KUO Mingchung; 片岡圭亮; 佐伯龍之介; 真田昌; 臼杵憲祐; 宮脇修一; 宮脇修一; 宮野悟; MACIEJEWSKI Jaroslaw; MACIEJEWSKI Jaroslaw; 牧島秀樹; 小川誠司; 小川誠司; 小川誠司
日本血液学会学術集会抄録(Web), 82nd, 2020年

Der(1;7) 陽性骨髄異形成症候群における人種,臨床像,遺伝学的観点からみた特徴
奥田瑠璃花; 南谷泰仁; 越智陽太郎; 蝶名林和久; 蝶名林和久; 牧島秀樹; 吉里哲一; 永田安伸; 竹田淳恵; 吉田健一; 真田昌; 真田昌; 昆彩奈; 白石友一; 宮野悟; 宮野悟; KERN Wolfgang; BAER Constance; NADARAJAH Niroshan; ALPERMANN Tamara; HAFERLACH Claudia; 熱田由子; 笠原千嗣; 半田寛; 千葉滋; 大屋敷一馬; HAFERLACH Torsten; 吉田善紀; 小川誠司; 小川誠司; 小川誠司
日本血液学会学術集会抄録(Web), 82nd, 2020年

単一細胞でのRNA/DNA同時シーケンスによるクローン造血の病態解明
中川正宏; 中川正宏; 稲垣良作; 稲垣良作; 稲垣良作; 黒田隆; 南谷泰仁; 趙蘭英; 趙蘭英; 越智陽太郎; 竹田淳恵; 戚星星; 依田成玄; 昆彩奈; 垣内伸之; 牧島秀樹; 松田秀一; 小川誠司; 小川誠司; 小川誠司
日本血液学会学術集会抄録(Web), 82nd, 2020年

慢性炎症に伴う胆管上皮におけるクローン拡大
前田紘奈; 前田紘奈; 垣内伸之; 平野智紀; 平野智紀; 竹内康英; 竹内康英; 伊藤孝司; 小川絵里; 塩川雅広; 宇座徳光; 田中洋子; 南谷泰仁; 牧島秀樹; 上本伸二; 宮野悟; 小川誠司; 小川誠司; 小川誠司
日本癌学会学術総会抄録集(Web), 79th, 2020年

Molecular Characteristics That Predict Response to Azacitidine Therapy
Yasuhito Nannya; Magnus Tobiasson; Elsa Bernard; Shinya Sato; Maria Creignou; June Takeda; Lanying Zhao; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Hisashi Tsurumi; Senji Kasahara; Masataka Taguchi; Akifumi Kondo Takaori; Kazuma Ohyashiki; Hideki Makishima; Kenichi Yoshida; Tomoki Naoe; Yasushi Miyazaki; Satoru Miyano; Elli Papaemmanuil; Eva Hellstrom Lindberg; Seishi Ogawa
BLOOD, 134, 2019年11月

Integrated Analysis of Copy-Number Alterations and Gene Mutations in 2,000 Patients with Myeloid Neoplasms
Ryunosuke Saiki; Yusuke Shiozawa; Tetsuichi Yoshizato; Yasuhito Nannya; June Takeda; Kenichi Yoshida; Yuichi Shiraishi; Hiroko Tanaka; Kenichi Chiba; Yoshiko Atsuta; Makoto Onizuka; Hidehiro Itonaga; Masashi Sanada; Yoshinobu Kanda; Bartlomiej Przychodzen; Mikkael A. Sekeres; Kathryn Guinta; Yogenthiran Saunthararajah; Lee-Yung Shih; Shuichi Miyawaki; Tsuyoshi Nakamaki; Masataka Taguchi; Shigeo Fuji; Nana Sasaki; Nobuhiko Uoshima; Yasunori Ueda; Yasushi Miyazaki; Kensuke Usuki; Kazunori Imada; Akifumi Takaori-Kondo; Shigeru Chiba; Senji Kasahara; Toru Kiguchi; Hisashi Tsurumi; Luca Malcovati; Mario Cazzola; Takayuki Ishikawa; Satoru Miyano; Jaroslaw P. Maciejewski; Hideki Makishima; Seishi Ogawa
BLOOD, 134, 2019年11月

CTX-712, a Novel Clk Inhibitor Targeting Myeloid Neoplasms with SRSF2 Mutation
Akinori Yoda; Daisuke Morishita; Akio Mizutani; Yoshihiko Satoh; Yotaro Ochi; Yasuhito Nannya; Hideki Makishima; Hiroshi Miyake; Seishi Ogawa
BLOOD, 134, 2019年11月

Novel Molecular Pathogenesis and Therapeutic Target in Acute Erythroid Leukemia
June Takeda; Kenichi Yoshida; Yasuhito Nannya; Lee-Yung Shih; Ayana Kon; Akinori Yoda; Yotaro Ochi; Yusuke Shiozawa; Tetsuichi Yoshizato; Cassandra M. Kerr; Yuichi Shiraishi; Kenichi Chiba; Yasunobu Nagata; Akira Hangaishi; Toshiyuki Kitano; Ken Ishiyama; Hisashi Tsurumi; Yasushi Miyazaki; Nobuhiro Hiramoto; Takayuki Ishikawa; Akifumi Takaori-Kondo; Masahiro Nakagawa; Masashi Sanada; Hideyuki Nakazawa; Keisuke Kataoka; Ryunosuke Saiki; Hiroko Tanaka; Kensuke Usuki; Shuichi Miyawaki; Satoru Miyano; Arnold Ganser; Michael Heuser; Jaroslaw P. Maciejewski; Felicitas Thol; Hideki Makishima; Seishi Ogawa
BLOOD, 134, 2019年11月

コヒーシンSTAG2およびRUNX1変異による骨髄異形成症候群発症の分子機構
越智陽太郎; 越智陽太郎; 昆彩奈; 中川正宏; 片岡圭亮; 古関明彦; 佐伯龍之介; 吉里哲一; 吉田健一; 依田成玄; 鈴木洋; 鶴山竜昭; 牧島秀樹; 塩澤裕介; 南谷泰仁; 杉原英志; 佐藤孝明; 真田昌; 高折晃史; 宮野悟; 小川誠司
日本癌学会学術総会抄録集(Web), 78回, E-1001, 2019年09月

Chronology and risk dependence of age-related remodelling of oesophageal epithelia
Akira Yokoyama; Nobuyuki Kakiuchi; Tetsuichi Yoshizato; Yasuhito Nannya; Hiromichi Suzuki; Yasuhide Takeuchi; Yusuke Shiozawa; Yusuke Sato; Kosuke Aoki; Soo Kim; Yoichi Fujii; Kenichi Yoshida; Keisuke Kataoka; Masahiro M. Nakagawa; Yoshikage Inoue; Tomonori Hirano; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Shinya Ohashi; Shin'ichi Miyamoto; Shigeru Tsunoda; Koshi Mimori; Sachiko Minamiguchi; Satoru Miyano; Hideki Makishima; Manabu Muto; Seishi Ogawa
CANCER RESEARCH, 79(13), 2019年07月

Myxofibrosarcoma is characterized by frequent abnormalities in TP53 and increased genetic instability
Yasuhide Takeuchi; Hiromichi Suzuki; Kenichi Yoshida; Yuichi Shiraishi; Nobuyuki Kakiuchi; Yusuke Shiozawa; Tetsuichi Yoshizato; Kenichi Chiba; Hideki Makishima; Satoru Miyano; Hironori Haga; Frederik Damm; Seishi Ogawa
CANCER SCIENCE, 109, 1433-1433, 2018年12月

Age-related remodeling of apparently normal esophageal epithelia by common cancer drivers
Akira Yokoyama; Tetsuichi Yoshizato; Nobuyuki Kakiuchi; Yasuhito Nannya; Hiromichi Suzuki; Yusuke Shiozawa; Yasuhide Takeuchi; Hideki Makishima; Shigeru Tsunoda; Masashi Sanada; Satoru Miyano; Manabu Muto; Seishi Ogawa
CANCER SCIENCE, 109, 884-884, 2018年12月

DNA Methylation and Genetic Profiles in 320 Patients with Myelodysplastic Syndromes
Suguru Morimoto; Hideki Makishima; Yasunobu Nagata; Niroshan Nadarajah; Constance Baer; Tamara Alpermann; Genta Nagae; Yasuhito Nannya; Yasushi Miyazaki; Kenichi Yoshida; Tetsuichi Yoshizato; Masahiro Marshall Nakagawa; Ryosaku Inagaki; June Takeda; Yoichi Fujii; Yasuhide Takeuchi; Hiroo Ueno; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Satoru Miyano; Claudia Haferlach; Wolfgang Kern; Hiroyuki Aburatani; Torsten Haferlach; Seishi Ogawa
BLOOD, 132, 2018年11月

The Prognostic Value of TP53 Mutations Depends on Clinical Backgrounds in Pediatric Patients with Acute Lymphoblastic Leukemia
Hiroo Ueno; Kenichi Yoshida; Yusuke Shiozawa; Yasuhito Nannya; Yuka Iijima-Yamashita; Nobutaka Kiyokawa; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Tomoya Isobe; Masafumi Seki; Shunsuke Kimura; Hideki Makishima; Nobuyuki Kakiuchi; Keisuke Kataoka; Tetsuichi Yoshizato; Hiroyuki Tsukamoto; Dai Nishijima; Takao Deguchi; Kentaro Ohki; Atsushi Sato; Hiroyuki Takahashi; Yoshiko Hashii; Sadao Tokimasa; Junichi Hara; Yoshiyuki Kosaka; Koji Kato; Takeshi Inukai; Junko Takita; Toshihiko Imamura; Satoru Miyano; Atsushi Manabe; Keizo Horibe; Seishi Ogawa; Masashi Sanada
BLOOD, 132, 2018年11月

MDSに対するアザシチジンの有効性を予測するゲノム異常(Comprehensive analysis for genetic factors predictive of azacitidine treatment for MDS)
南谷 泰仁; 竹田 淳恵; 佐藤 信也; 趙 蘭英; 塩澤 裕介; 白石 友一; 千葉 健一; 田中 洋子; 眞田 昌; 中村 信彦; 鶴見 寿; 柴田 悠平; 笠原 千嗣; 上条 玲奈; 田口 正剛; 半田 寛; 臼杵 憲祐; 高折 晃史; 千葉 滋; 麻生 範雄; 清井 仁; 直江 知樹; 牧島 秀樹; 吉田 健一; 宮野 悟; 宮崎 泰司; 小川 誠司
臨床血液, 59(9), 1588-1588, 2018年09月

褐色細胞腫の遺伝学的解析(Genetic analysis of pheochromocytoma)
小笠原 辰樹; 藤井 陽一; 藤本 真徳; 塩澤 裕介; 吉里 哲一; 鈴木 啓道; 吉田 健一; 牧島 秀樹; 宮野 悟; 田中 知明; 小川 誠司
日本癌学会総会記事, 77回, 1259-1259, 2018年09月

骨髄異形成症候群におけるder(1;7)に伴う遺伝子異常の意義(Distinct ethnic, genetic and phenotypic characteristics of der(1;7) in myelodysplastic syndromes)
奥田 瑠璃花; 牧島 秀樹; 吉里 哲一; 南谷 泰仁; 永田 安伸; 竹田 淳恵; 吉田 健一; 眞田 昌; 白石 友一; 宮野 悟; Kern Wolfgang; Baer Constance R; Nadarajah Niroshan; Alpermann Tamara; Haferlach Claudia; 笠原 千嗣; 半田 寛; 千葉 滋; Haferlach Torsten; 小川 誠司
臨床血液, 59(9), 1588-1588, 2018年09月

Comprehensive analysis of genetic alterations and intratumor heterogeneity in myxofibrosarcoma
Yasuhide Takeuchi; Annegret Kunitz; Hiromichi Suzuki; Kenichi Yoshida; Nobuyuki Kakiuchi; Yusuke Shiozawa; Akira Yokoyama; Yoichi Fujii; Tetsuichi Yoshizato; Kosuke Aoki; Keisuke Kataoka; Yasuhito Nannya; Yuichi Shiraishi; Teppei Shimamura; Kenichi Chiba; Hiroko Tanaka; Hideki Makishima; Satoru Miyano; Hironori Haga; Frederik Damm; Seishi Ogawa
CANCER RESEARCH, 78(13), 2018年07月

Cohesin subunit Stag2 regulates hematopoietic differentiation and self-renewal
Yotaro Ochi; Ayana Kon; Kenichi Yoshida; Keisuke Kataoka; Masahiro Marshall Nakagawa; Hideki Makishima; Haruhiko Koseki; Akifumi Takaori-Kondo; Seishi Ogawa
CANCER SCIENCE, 109, 510-510, 2018年01月

Comprehensive Analysis of Genetic Alterations and Intratumor Heterogeneity in Myxofibrosarcoma
Yasuhide Takeuchi; Hiromichi Suzuki; Kenichi Yoshida; Yuichi Shiraish; Teppei Shimamura; Tetsuichi Yoshizato; Yusuke Shiozawa; Kenichi Chiba; Hideki Makishima; Satoru Miyano; Hironori Haga; Frederik Damm; Seishi Ogawa
CANCER SCIENCE, 109, 716-716, 2018年01月

Stag2 regulates Hematopoietic Differentiation and Self-Renewal
Yotaro Ochi; Ayana Kon; Kenichi Yoshida; Keisuke Kataoka; Masahiro Marshall Nakagawa; Hideki Makishima; Manabu Nakayama; Haruhiko Koseki; Akifumi Takaori-Kondo; Seishi Ogawa
BLOOD, 130, 2017年12月

Comprehensive Sequencing Analysis in Subcutaneous Panniculitis-like T-Cell Lymphoma
Chantana Polprasert; Yasuhide Takeuchi; Hideki Makishima; Nobuyuki Kakiuchi; Kenichi Yoshida; Keisuke Kataoka; Masashi Sanada; Nobuhiro Akita; Yuichi Shiraishi; Yusuke Shiozawa; Kenichi Chiba; Hiroko Tanaka; Thamathorn Assanasen; Wimonmas Sitthi; Arunrat Pirunsarn; Udomsak Bunworasate; Kitsada Wudhikarn; Panisinee Lawasut; Sunisa Kongkiatkamon; Satoru Miyano; Ponlapat Rojnuckarin; Seishi Ogawa
BLOOD, 130, 2017年12月

Clinical Effect of Genetic Alterations in Pediatric Patients with B-Progenitor Acute Lymphoblastic Leukemia
Hiroo Ueno; Kenichi Yoshida; Yasuhito Nannya; Yuka Iijima-Yamashita; Yusuke Shiozawa; Yuichi Shiraishi; Tomomi Ishida; Keisuke Kataoka; Tetsuichi Yoshizato; Hideki Makishima; Nobuyuki Kakiuchi; Masafumi Seki; Hiroko Tanaka; Kenichi Chiba; Takao Deguchi; Atsushi Sato; Yoshiko Hashii; Sadao Tokimasa; Junichi Hara; Yoshiyuki Kosaka; Koji Kato; Toshihiko Imamura; Satoru Miyano; Keizo Horibe; Seishi Ogawa; Masashi Sanada
BLOOD, 130, 2017年12月

A Novel Prediction Model Integrating Genomic and Clinical Features in Pediatric B-Progenitor Acute Lymphoblastic Leukemia
Hiroo Ueno; Kenichi Yoshida; Yasuhito Nannya; Yuka Iijima; Yusuke Shiozawa; Yuichi Shiraishi; Tomomi Ishida; Hiroyuki Tsukamoto; Keisuke Kataoka; Tetsuichi Yoshizato; Hideki Makishima; Nobuyuki Kakiuchi; Masafumi Seki; Mayumi Kibe; Hiroko Tanaka; Kenichi Chiba; Takao Deguchi; Atsushi Sato; Yoshiko Hashii; Sadao Tokimasa; Junichi Hara; Yoshiyuki Kosaka; Koji Kato; Toshihiko Imamura; Satoru Miyano; Seishi Ogawa; Keizo Horibe; Masashi Sanada
PEDIATRIC BLOOD & CANCER, 64, S13-S14, 2017年11月

粘液線維肉腫の遺伝子変異、腫瘍内多様性の検討
竹内 康英; 鈴木 啓道; 吉田 健一; 白石 友一; 島村 徹平; 吉里 哲一; 塩澤 裕介; 千葉 健一; 牧島 秀樹; 宮野 悟; 羽賀 博典; Damm Frederik; 小川 誠司
日本癌学会総会記事, 76回, P-2294, 2017年09月

Comprehensive genetic analysis of myxofibrosarcoma and comparison with other soft tissue sarcomas
Yasuhide Takeuchi; Annegret Kunitz; Hiromichi Suzuki; Kenichi Yoshida; Yuichi Shiraishi; Teppei Shimamura; Kenichi Chiba; Hiroko Tanaka; Nobuyuki Kakiuchi; Yusuke Shiozawa; Akira Yokoyama; Tetsuichi Yoshizato; Kosuke Aoki; Yoichi Fujii; Hideki Makishima; Hironori Haga; Satoru Miyano; Frederik Damm; Seishi Ogawa
CANCER RESEARCH, 77, 2017年07月

Differential role of mutations in clonal evolution in esophageal mucosa at risk for cancer
Akira Yokoyama; Hiromichi Suzuki; Tetsuichi Yoshizato; Yuusuke Shiozawa; Yusuke Sato; Kosuke Aoki; Nobuyuki Kakiuchi; Yasuhide Takeuchi; Yoichi Fujii; Hideki Makishima; Kenichi Yoshida; Keisuke Kataoka; Yaichi Shiraishi; Masashi Sanada; Shigeru Tsunoda; Sachiko Minamiguchi; Satoru Miyano; Manabu Muto; Seishi Ogawa
CANCER RESEARCH, 77, 2017年07月

A NOVEL GENETIC AND MORPHOLOGIC PHENOTYPE OF ARID2-MEDIATED MYELODYSPLASTIC SYNDROMES
H. Sakai; N. Hosono; H. Nakazawa; B. Przychodzen; C. Polprasert; H. Carraway; M. Sekeres; T. Radivoyevitch; K. Yoshida; M. Sanada; T. Yoshizato; K. Kataoka; M. Nakagawa; H. Ueno; Y. Nannya; K. Ayana; Y. Shiozawa; J. Takeda; Y. Shiraishi; K. Chiba; S. Miyano; J. Singh; R. Padgett; S. Ogawa; J. Maciejewski; H. Makishima
HAEMATOLOGICA, 102, 11-11, 2017年06月

GENETIC LANDSCAPE OF ACUTE ERYTHROID LEUKEMIA
J. Takeda; L. -Y. Shih; K. Chiba; Y. Shiraishi; Y. Shiozawa; H. Makishima; T. Yoshizato; Y. Nagata; A. Hangaishi; K. Ishiyama; A. Takaori-Kondo; K. Kataoka; M. Sanada; H. Tanaka; K. Usuki; S. Miyawaki; S. Miyano; A. Ganser; M. Heuser; S. Ogawa; F. Thol; K. Yoshida
HAEMATOLOGICA, 102, 205-206, 2017年06月

TRANSCRIPTOME SEQUENCING REVEALS DISTINCT SUBTYPES OF MYELODYSPLASIA WITH PROGNOSTIC SIGNIFICANCE
Y. Shiozawa; L. Malcovati; A. Galli; A. Pellagatti; M. Karimi; A. Sato-Otsubo; Y. Sato; H. Suzuki; T. Yoshizato; K. Yoshida; Y. Shiraishi; K. Chiba; H. Makishima; J. Boultwood; S. Miyano; M. Cazzola; S. Ogawa
HAEMATOLOGICA, 102, 12-13, 2017年06月

ANCESTRAL EVENTS INCLUDING GERMLINE AND SOMATIC MUTATIONS DETERMINE SUBCLONAL EVENTS AND AFFECT PHENOTYPE OF PROGRESSION IN MDS
Y. Nagata; H. Makishima; T. Radivoyevitch; C. Hirsch; B. Przychodzen; T. Kuzmanovic; S. Li; K. Yoshida; H. Suzuki; V. Adema; M. Clemente; Y. Shiraishi; K. Chiba; H. Tanaka; F. Sole; S. Miyano; M. Sekeres; T. LaFramboise; S. Ogawa; J. Maciejewski
LEUKEMIA RESEARCH, 55, S8-S8, 2017年04月

DISTINCT GENOMIC LANDSCAPE OF UPPER URINARY TRACT UROTHELIAL CARCINOMA
Yoichi Fujii; Yusuke Sato; Hiromichi Suzuki; Tetsuichi Yoshizato; Yusuke Shiozawa; Kenichi Yoshida; Yuichi Shiraishi; Tohru Nakagawa; Haruki Kume; Hiroaki Nishimatsu; Toshikazu Okaneya; Masashi Sanada; Hideki Makishima; Satoru Miyano; Seishi Ogawa; Yukio Homma
JOURNAL OF UROLOGY, 197(4), E944-E945, 2017年04月

Landscape of Subclonal Mutations in Myelodysplastic Syndromes (MDS) Allows for a Novel Hierarchy of Clonal Advantage By Combining Germline and Somatic Mutations
Yasunobu Nagata; Hideki Makishima; Tomas Radivoyevitch; Cassandra M. Hirsch; Bartlomiej P. Przychodzen; Teodora Kuzmanovic; Samuel Li; Kenichi Yoshida; Tetsuichi Yoshizato; Vera Adema; Eiju Negoro; Michael J. Clemente; Naoko Hosono; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Sudipto Mukherjee; Aziz Nazha; Francesc Sole; Hetty E. Carraway; Satoru Miyano; Thomas LaFramboise; Mikkael A. Sekeres; Seishi Ogawa; Jaroslaw P. Maciejewski
BLOOD, 128(22), 2016年12月

NGS-Based Copy Number Analysis in 1,185 Patients with Myeloid Neoplasms
Ryunosuke Saiki; Yusuke Shiozawa; Tetsuichi Yoshizato; Kenichi Yoshida; Yuichi Shiraishi; Hiroko Tanaka; Kenichi Chiba; Yoshiko Atsuta; Makoto Onizuka; Hidehiro Itonaga; Yoshinobu Kanda; Mikkael A. Sekeres; Kathryn M. Guinta; Shuichi Miyawaki; Tsuyoshi Nakamaki; Shigeru Chiba; Lee-Yung Shih; Yasushi Miyazaki; Satoru Miyano; Hideki Makishima; Jaroslaw P. Maciejewski; Seishi Ogawa
BLOOD, 128(22), 2016年12月

The Role of LUC7L2 in Splicing and MDS
Courtney Elizabeth Hershberger; Naoko Hosono; Jarnail Singh; Rosemary C. Dietrich; Xiaorong Gu; Hideki Makishima; Yogen Saunthararajah; Jaroslaw P. Maciejewski; Richard A. Padgett
BLOOD, 128(22), 2016年12月

Clonal Events of Aplastic Anemia Related to the Evolution to Myelodysplastic Syndrome
Eiju Negoro; Michael Clemente; Naoko Hosono; Aziz Nazha; Wenyi Shen; Yasunobu Nagata; Cassandra M. Hirsch; Bartlomiej P. Przychodzen; Reda Z. Mahfouz; Teodora Kuzmanovic; Hideki Makishima; Mikkael A. Sekeres; Jaroslaw P. Maciejewski
BLOOD, 128(22), 2016年12月

Quantification of Erythroblast- and Myelocyte-Derived mRNAs in Plasma Exosomes As an Indicator of Bone Marrow Status in Patients with Various Types of Anemias and Myeloproliferative Disorders
Masato Mitsuhashi; Taku Murakami; Teodora Kuzmanovic; Cassandra M. Hirsch; Hideki Makishima; Jaroslaw P. Maciejewski
BLOOD, 128(22), 2016年12月

UTX mutations in Myeloid Neoplasms
Yasunobu Nagata; Tomas Radivoyevitch; Hideki Makishima; Cassandra M. Hirsch; Bartlomiej P. Przychodzen; Teodora Kuzmanovic; Eiju Negoro; Michael J. Clemente; Sudipto Mukherjee; Hetty E. Carraway; Mikkael A. Sekeres; Jaroslaw P. Maciejewski
BLOOD, 128(22), 2016年12月

Clinical Significance of Mutations and Copy Number Lesions on Prognosis of Patients with MDS after Unrelated Bone Marrow Transplantation
Tetsuichi Yoshizato; Yoshiko Atsuta; Yusuke Shiozawa; Kenichi Yoshida; Yasuhito Nannya; Hiromichi Suzuki; Keitaro Matsuo; Makoto Onizuka; Keisuke Kataoka; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Kosuke Aoki; Masashi Sanada; Hidehiro Itonaga; Yoshinobu Kanda; Yasushi Miyazaki; Hideki Makishima; Satoru Miyano; Seishi Ogawa
BLOOD, 128(22), 2016年12月

Combined DNA and Transcriptome Sequencing Reveals Discrete Subtypes of Myelodysplasia
Yusuke Shiozawa; Luca Malcovati; Anna Galli; Andrea Pellagatti; Hiromichi Suzuki; Tetsuichi Yoshizato; Yusuke Sato; Keisuke Kataoka; Kenichi Yoshida; Kenichi Yoshida; Masashi Sanada; Hideki Makishima; Yuichi Shiraishi; Kenichi Chiba; Satoru Miyano; Jacqueline Boultwood; Eva Hellstroem-Lindberg; Seishi Ogawa; Mario Cazzola
BLOOD, 128(22), 2016年12月

Deletion of PTPN1 Promotes the Development of Myelofibrosis
Fatoumata Jobe; Bhumika Patel; Hideki Makishima; Bartlomiej P. Przychodzen; Robert E. Hutchison; Kendra K. Bence; Jaroslaw P. Maciejewski; Golam Mohi
BLOOD, 128(22), 2016年12月

Genetic Landscape and Clonal Evolution Following 5-Aza Therapy in Patients with High-Risk Myelodysplastic Syndromes
June Takeda; Yusuke Shiozawa; Yuichi Shiraishi; Yusuke Okuno; Keisuke Kataoka; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Shigeru Chiba; Norio Asou; Hitoshi Kiyoi; Kiyotoshi Imai; Chikara Hirase; Nobuaki Dobashi; Toru Kiguchi; Yasushi Miyazaki; Tomoki Naoe; Hideki Makishima; Satoru Miyano; Seishi Ogawa; Kenichi Yoshida
BLOOD, 128(22), 2016年12月

U2AF1 Mutations in S34 and Q157 Create Distinct Molecular and Clinical Contexts
Vera Adema; Cassandra M. Hirsch; Bartlomiej P. Przychodzen; Aziz Nazha; Teodora Kuzmanovic; Eiju Negoro; Dewen You; Hideki Makishima; Michael J. Clemente; Hetty E. Carraway; Mikkael A. Sekeres; Valeria Visconte; Jaroslaw P. Maciejewski
BLOOD, 128(22), 2016年12月

Clinical and Biological Implications of CUX1 Mutations in Myeloid Neoplasms
Mai Aly; Naoko Hosono; Przychodzen Bartlomiej; Hideki Makishima; Nagata Yasunobu; Cassandra M. Hirsch; Mikkael A. Sekeres; Jaroslaw P. Maciejewski
BLOOD, 128(22), 2016年12月

PHF6 Somatic Mutations and Their Functional Role in the Pathophysiology of Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)
Bartlomiej P. Przychodzen; Xiaorong Gu; Dewen You; Cassandra M. Hirsch; Michael J. Clemente; Mikkael A. Sekeres; Aziz Nazha; Hideki Makishima; Jaroslaw P. Maciejewski
BLOOD, 128(22), 2016年12月

MDS/AML発症における胚細胞変異
牧島 秀樹
血液内科 = Hematology, 73(2), 215-220, 2016年08月

CLONAL DYNAMICS OF TWO DISTINCT CLONES IN LEUKEMIC TRANSFORMATION FROM MDS WITH ISOLATED DEL(5Q) HARBORING TP53 MUTATION
H. Tsukamoto; Y. Watatani; K. Yoshida; Y. Yamashita; H. Tanaka; K. Chiba; Y. Shiraishi; Y. Kawaguchi; S. Fujiwara; N. Kabasawa; N. Hattori; H. Makishima; S. Miyano; S. Ogawa; T. Nakamaki; M. Sanada
HAEMATOLOGICA, 101, 496-497, 2016年06月

IMPACT OF SOMATIC MUTATIONS ON OUTCOME IN PATIENTS WITH MDS AFTER STEM-CELL TRANSPLANTATION
T. Yoshizato; Y. Shiozawa; K. Yoshida; Y. Atsuta; N. Yasuhito; H. Suzuki; M. Onizuka; K. Kataoka; K. Chiba; H. Tanaka; Y. Shiraishi; K. Aoki; M. Sanada; H. Itonaga; Y. Kanda; Y. Miyazaki; H. Makishima; S. Miyano; S. Ogawa
HAEMATOLOGICA, 101, 67-68, 2016年06月

Prognostic Relevance of Integrated Genetic Profiling in Adult T-Cell Leukemia/Lymphoma
Keisuke Kataoka; Yasunobu Nagata; Akira Kitanaka; Jun-ichirou Yasunaga; Masako Iwanaga; Yuichi Shiraishi; Kenichi Chiba; Aiko Sato-Otsubo; Masashi Sanada; Hiroko Tanaka; Hiromichi Suzuki; Yusuke Sato; Yusuke Shiozavva; Tetsuichi Yoshizato; Kenichi Yoshida; Hideki Makishima; Kisato Nosaka; Masakatsu Hishizawa; Hidehiro Itonaga; Yoshitaka Imaizumi; Wataru Munakata; Kotaro Shide; Yoko Kubuki; Tomonori Hidaka; Takuro Kameda; Tsuyoshi Nakamaki; Ken Ishiyama; Shuichi Miyawaki; Kensei Tobinai; Yasushi Miyazaki; Akifumi Takaori-Kondo; Tatsuhiro Shibata; Satoru Miyano; Masao Matsuoka; Kazuya Shimoda; Toshiki Watanabe; Seishi Ogawa
BLOOD, 126(23), 2015年12月

Network-Based Analysis of Exome Sequencing Mutations Identifies Molecular Subtypes of Myelodysplastic Syndromes
Aziz Nazha; Bartlomiej Przychodzen; Hideki Makishima; Hetty E. Carraway; Bhumika J. Patel; Cassandra M. Hirsch; Michael Clemente; Srinivasa R. Sanikommu; Aaron T. Gerds; Jennifer S. Carew; Satoru Miyano; Matt Kalaycio; Seishi Ogawa; Jaroslaw P. Maciejewski; Mikkael A. Sekeres
BLOOD, 126(23), 2015年12月

Myelodysplastic Syndrome (MDS)-Determining Clonal Events at Presentation of Aplastic Anemia (AA)
Eiju Negoro; Naoko Hosono; Wenyi Shen; Tetsuichi Yoshizato; Bhumika J. Patel; Cassandra Hirsh; Bartlomiej Przychodzen; Michael J. Clemente; Reda Z. Mahfouz; Aleksandra Wodnar-Filipowicz; Hideki Makishima; Seishi Ogawa; Mikkael A. Sekeres; Jaroslaw P. Maciejewski
BLOOD, 126(23), 2015年12月

Impact of Somatic Mutations on Outcome in Patients with MDS after Stem-Cell Transplantation
Tetsuichi Yoshizato; Yusuke Shiozawa; Kenichi Yoshida; Yoshiko Atsuta; Chika Ito; Keisuke Kataoka; Makoto Onizuka; Hiromichi Suzuki; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Yasunobu Nagata; Masashi Sanada; Hidehiro Itonaga; Yoshinobu Kanda; Yasushi Miyazaki; Hideki Makishima; Satoru Miyano; Seishi Ogawa
BLOOD, 126(23), 2015年12月

Different Mutant Splicing Factors Cause Distinct Missplicing Events and Give Rise to Different Clinical Phenotypes in Myelodysplastic Syndromes
Yusuke Shiozawa; Luca Malcovati; Aiko Sato-Otsubo; Anna Galli; Kenichi Yoshida; Tetsuichi Yoshizato; Yusuke Sato; Keisuke Kataoka; Masashi Sanada; Hideki Makishima; Yuichi Shiraishi; Kenichi Chiba; Satoru Miyano; Eva Hellstroem Lindberg; Seishi Ogawa; Mario Cazzola
BLOOD, 126(23), 2015年12月

Serial Sequencing in Myelodysplastic Syndromes Reveals Dynamic Changes in Clonal Architecture and Allows for a New Prognostic Assessment of Mutations Detected in Cross-Sectional Testing
Hideki Makishima; Kenichi Yoshida; Thomas LaFramboise; Tetsuichi Yoshizato; Matthew Ruffalo; Mikkael A. Sekeres; Bartlomiej Przychodzen; Hiromichi Suzuki; Masashi Sanada; Yasunobu Nagata; Yusuke Okuno; Yusuke Sato; Aiko Sato-Otsubo; Michael J. Clemente; Naoko Hosono; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Yusuke Shiozawa; Ines Gomez-Segui; Holleh Husseinzadeh; Swapna Thota; Kathryn Guinta; Brittney Dienes; Tsuyoshi Nakamaki; Shuichi Miyawaki; Yogen Saunthararajah; Shigeru Chiba; Satoru Miyano; Lee-Yung Shih; Seishi Ogawa; Jaroslaw P. Maciejewski
BLOOD, 126(23), 2015年12月

Whole-Exome Sequencing Identifies Germline IDH2 and IDH3 mutations That Predispose to Myeloid Neoplasms
Remco Molenaar; Srinivasa Reddy Sanikommu; Bhumika J. Patel; Bartlomiej Przychodzen; Cornelis J. van Noorden; Tomas Radivoyevitch; Hideki Makishima; Hetty E. Carraway; Jaroslaw P. Maciejewski
BLOOD, 126(23), 2015年12月

TET 2 Alterations in Myeloid Malignancies, Impact on Clinical Characteristics, Outcome, and Disease Predisposition
Aziz Nazha; Manja Meggendorfer; Niroshan Nadarajah; Kassy E. Kneen; Tomas Radivoyevitch; Bartlomiej Przychodzen; Hideki Makishima; Bhumika J. Patel; Srinivasa R. Sanikommu; Sean Hobson; Mridul Mukherji; Mikkael A. Sekeres; Torsten Haferlach; Jaroslaw P. Maciejewski
BLOOD, 126(23), 2015年12月

New Allosteric Inhibitors of Mutant IDH1 in Acute Myeloid Leukemia
Ujunwa Cynthia Okoye-Okafor; Boris Bartholdy; Jessy Cartier; Enoch Gao; Beth Pietrak; Alan R. Rendina; Cynthia Rominger; Chad Quinn; Angela Smallwood; Ken Wiggall; Alexander Reif; Stan Schmidt; Hongwei Qi; Huizhen Zhao; Gerard Joberty; Maria Faelth-Savitski; Marcus Bantscheff; Gerard Drewes; Chaya Duraiswami; Pat Brady; Swathi-rao Narayanagari; Ileana Antony-Debre; Kelly Mitchell; Luis Carvajal; Heng Rui Wang; Laura Barreyro; Yun-Ruei Kao; Maximilian Christopeit; Elisabeth Paietta; Hideki Makishima; Britta Will; Nestor Concha; Nicholas Adams; Benjamin Schwartz; Michael T. McCabe; Jaroslaw P. Maciejewski; Amit Verma; Ulrich Steidl
BLOOD, 126(23), 2015年12月

Genetic Predispositions to Myeloid Neoplasms Caused By Germline DDX41 Mutations
June Takeda; Kenichi Yoshida; Hideki Makishima; Tetsuichi Yoshizato; Yusuke Shiozama; Yuichi Shiraishi; Yusuke Okuno; Ayana Kon; Yasunobu Nagata; Keisuke Kataoka; Kenichi Chiba; Hiroko Tanaka; Masashi Sanada; Mamiko Sakata-Yanagimoto; Naoshi Obara; Tsuyoshi Nakamaki; Ken Ishiyama; Akira Haigaishi; Shigeru Chiba; Hiraku Mori; Norio Asou; Hitoshi Kiyoi; Chikara Hirase; Kiyotoshi Imai; Nobuaki Dobashi; Toru Kiguchi; Yasushi Miyazaki; Tomoki Naoe; Satoru Miyano; Kensuke Usuki; Shuichi Miyawaki; Yoichiro Kamatani; Yukihide Momozawa; Michiaki Kubo; Chantana Polprasert; Jaroslaw P. Maciejewski; Seishi Ogawa
BLOOD, 126(23), 2015年12月

Two Novel Distinct Subtypes of Myeloid Neoplasms Molecularly Associated with Histone H3K36 Methylations
Yosaku Watatani; Yasunobu Nagata; Vera Grossmann; Yusuke Okuno; Tetsuichi Yoshizato; Yusuke Shiozawa; Genta Nagae; Kenichi Yoshida; Keisuke Kataoka; Susanne Schnittger; Masashi Sanada; Ayana Kon; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Tsuyoshi Nakamaki; Shuichi Miyawaki; Shigeru Chiba; Tamara Alpermann; Niroshan Nadarajah; Phillip Koeffler; Hans-Ulrich Klein; Martin Dugas; Hiroyuki Aburatani; Claudia Haferlach; Wolfgang Kern; Satoru Miyano; Lee-Yung Shih; Seishi Ogawa; Torsten Haferlach; Hideki Makishima
BLOOD, 126(23), 2015年12月

Ex Vivo Experiments Show That IDH1/2-Mutant Inhibitors Can be Safely Used As Adjuvants to Regular Chemotherapy in IDH1/2-Mutated Acute Myeloid Leukemia
Remco Molenaar; Bhumika J. Patel; Mohammed Khurshed; Bartlomiej Przychodzen; Srinivasa Reddy Sanikommu; Hetty E. Carraway; Tomas Radivoyevitch; Hideki Makishima; Cornelis J. van Noorden; Jaroslaw P. Maciejewski
BLOOD, 126(23), 2015年12月

Molecular Predictors of Response in Patients with Myeloid Neoplasms Treated with Lenalidomide
Eiju Negoro; Chantana Polprasert; Tomas Radivoyevitch; Vera Adema; Naoko Hosono; Hideki Makishima; Bartlomiej Przychodzen; Mikkael A. Sekeres; Valeria Santini; Kathy McGaw; Alan F. List; Francesc Sole; Jaroslaw P. Maciejewski
BLOOD, 126(23), 2015年12月

The human GFI136N variant is a novel prognostic marker that offers potential for personalized treatment approach for Myelodysplastic (MDS) and Acute Myeloid Leukemia (AML) patients
L. Botezatu; H. Makishima; L. Michel; J. M. Hoenes; L. Vassen; C. Vadnais; A. Helness; A. Mameth; B. van der Reijden; T. Radiovoyevich; U. Germing; R. Hass; T. Schroeder; U. Platzbecker; G. Ehninger; E. Lindberg; M. Cazzola; J. Boultwood; A. Goergens; B. Giebel; U. Duehrsen; J. Maciejewski; T. Moray; C. Khandanpour
Oncology Research and Treatment, 38, 259-260, 2015年10月

Gfi1 as a novel prognostic marker and for myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) and offers a novel personalized treatment
L. Botezatu; J. M. Hoenes; L. Michel; C. Thiede; B. van der Reijden; M. Heuser; H. Makishima; R. Thomas; M. Jaroslaw; G. Ehninger; T. Moroy; U. Duehrsen; C. Khandanpour
Oncology Research and Treatment, 38, 185-185, 2015年10月

ALK-Rearranged NSCLC Adaptive Cell Plasticity with Early Onset TGFb2 Mediated Precision Drug Escape through PRC-2 Epigenetic Reprogramming
Patrick C. Ma; Lihong Yin; Wei Zhang; Ivy Shi; Xiaoliang Wu; James Phillips; Humberto Choi; Hideki Makishima; Daniel Lindner; Yan Feng; Francisco Almeida; Jaroslaw P. Maciejewski; Yogen Saunthararajah; Zhenfeng Zhang
JOURNAL OF THORACIC ONCOLOGY, 10(9), S256-S256, 2015年09月

Obesity and genomic changes in patients with myelodysplastic syndromes
Aziz Nazha; David Seastone; Hideki Makishima; Matt Kalaycio; Hetty E. Carraway; Anjali S. Advani; Ahamd Zarzour; Jennifer Carew; Aaron T. Gerds; Sudipto Mukherjee; Jaroslaw P. Maciejewski; Mikkael A. Sekeres
CANCER RESEARCH, 75, 2015年08月

APC mutations in myeloid malignancies: Incidence and impact on leukemogenesis.
Aziz Nazha; Bartlomiej Przychodzen; Hideki Makishima; Mayur Narkhede; Matt E. Kalaycio; David James Seastone; Hetty Carraway; Aaron Thomas Gerds; Sudipto Mukherjee; Anjali S. Advani; Jennifer Carew; Mikkael A. Sekeres; Jaroslaw P. Maciejewski
JOURNAL OF CLINICAL ONCOLOGY, 33(15), 2015年05月

SUBCLINICAL ANCESTRAL EVENTS FOR PROGRESSION TO MANIFEST CLONAL MYELODYSPLASIA ARE PRESENT IN APLASTIC ANEMIA AT PRESENTATION: COMPARISON OF DE NOVO AND POST AA MDS
E. Negoro; N. Hosono; W. Shen; B. Przychozen; B. Patel; Y. Tetsuichi; D. Brittney; H. Cassandra; C. Polprasert; M. Clemente; M. Sekeres; S. Ogawa; H. Makishima; J. Maciejewski
LEUKEMIA RESEARCH, 39, S32-S33, 2015年04月

SUBCLASSIFICATION OF CHRONIC MYELOMONOCYTIC LEUKEMIA BY ANCESTRAL MUTATIONAL EVENTS
B. Patel; D. Huang; S. Thota; B. Przychodzen; H. Sakaguchi; S. Kojima; S. Ogawa; M. A. Sekeres; H. Makishima; J. P. Maciejewski
LEUKEMIA RESEARCH, 39, S33-S33, 2015年04月

SOMATIC MUTATIONAL MODEL TO PREDICT RESPONSE TO HYPOMETHYLATING AGENTS IN MYELODYSPLASTIC SYNDROMES
A. Nazha; T. Radivoyevitch; S. Thota; H. Makishima; B. Patel; D. Seastone; H. Carraway; J. Carew; B. Przychodzen; M. Kalaycio; M. Sekeres; J. Maciejewski
LEUKEMIA RESEARCH, 39, S9-S9, 2015年04月

FOUNDER AND SUBCLONAL SOMATIC MUTATIONS CONTRIBUTING TO LEUKEMIC EVOLUTION IN MYELODYSPLASTIC SYNDROMES AND RELATED MYELOID NEOPLASMS
H. Makishima; K. Yoshida; B. Przychodzen; T. Swapna; B. Patel; Y. Nagata; S. Miyano; M. Sekeres; L. Shih; S. Ogawa; J. Maciejewski
LEUKEMIA RESEARCH, 39, S135-S136, 2015年04月

PERSONALIZED TREATMENT APPROACH FOR GFI136N HETEROZYGOUS OR HOMOZYGOUS MDS PATIENTS
B. Lacramioara; H. Makishima; L. Michel; J. Hoenes; A. Marneth; B. van der Reijden; T. Radiovoyevich; U. Germing; R. Haas; T. Schroeder; C. Vadnais; A. Helness; J. Pimanda; J. Jansen; A. Unnikrishnan; U. Platzbecker; E. Papaemmanuil; G. Ehninger; T. Moroy; U. Duhrsen; J. Maciejewski; C. Khandanpour
LEUKEMIA RESEARCH, 39, S35-S35, 2015年04月

Angioimmunoblastic T Cell Lymphomas (AITL) With the RHOA G17V Mutation Have Classic Pathologic Features
Sarah Ondrejka; Bartosz Grzywacz; Hideki Makishima; Jaroslaw Maciejewski; Eric Hsi
MODERN PATHOLOGY, 28, 370A-370A, 2015年02月

Clonal Hierarchy and Diagnostic and Prognostic Impact of Founder Mutations in Myeloid Neoplasms
H. Makishima; B. Przychodzen; N. Hosano; S. Thota; B. Patel; M. Sekeres; J. P. Maciejewski
ANNALS OF HEMATOLOGY, 94, S37-S37, 2015年02月

Angioimmunoblastic T Cell Lymphomas (AITL) With the RHOA G17V Mutation Have Classic Pathologic Features
Sarah Ondrejka; Bartosz Grzywacz; Hideki Makishima; Jaroslaw Maciejewski; Eric Hsi
LABORATORY INVESTIGATION, 95, 370A-370A, 2015年02月

Hereditary Mutations Are Present As Pathogenic or Predisposition Factors in Otherwise Typical Adult MDS
Bartlomiej P. Przychodzen; Hideki Makishima; Brittney Dienes; Tomas Radivoyevitch; Hetty E. Carraway; Swapna Thota; Bhumika J. Patel; Mikkael A. Sekeres; Jaroslaw P. Maciejewski
BLOOD, 124(21), 2014年12月

DDX41 Is a Tumor Suppressor Gene Associated with Inherited and Acquired Mutations
Chantana Polprasert; Isabell Schulze; Mikkael A. Sekeres; Hideki Makishima; Bartlomiej P. Przychodzen; Naoko Hosono; Jarnail Singh; Richard A. Padgett; Xiaorong Gu; Eckhard Jankowsky; Michael Clemente; Brittney Dienes; Sudipto Mukherjee; Utz Krug; Hans-Ulrich Klein; Martin Dugas; Wolfgang E. Berdel; Kenichi Yoshida; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Seishi Ogawa; Carsten Mueller-Tidow; Jaroslaw P. Maciejewski
BLOOD, 124(21), 2014年12月

Dose Dependent Role of Gfi1 in Human MDS and AML and Its Suitability As a Novel Target
Judith Maria Hoenes; Lacramioara Botezatu; Lars C. Michel; Christian Thiede; Bert van der Reijden; Michael Heuser; Hideki Makishima; Jaroslaw P. Maciejewski; Tomas Radiovoyevitch; Gerhard Ehninger; Ulrich Duehrsen; Tarik Moroy; Cyrus Khandanpour
BLOOD, 124(21), 2014年12月

In Analogy to AML, MDS Can be Sub-Classified By Ancestral Mutations
Hideki Makishima; Kenichi Yoshida; Thomas LaFramboise; Bartlomiej P. Przychodzen; Matthew Ruffalo; Ines Gomez-Segui; Yuichi Shiraishi; Masashi Sanada; Yasunobu Nagata; Yusuke Sato; Aiko Sato-Otsubo; Kenichi Chiba; Hiroko Tanaka; Tsuyoshi Nakamaki; Wolf-Karsten Hofmann; Shuichi Miyawaki; Shigeru Chiba; Satoru Miyano; Holleh Husseinzadeh; Naoko Hosono; Chantana Polprasert; Bhumika J. Patel; Swapna Thota; Brittney Dienes; Kathryn M. Guinta; Lee-Yung Shih; Yogen Saunthararajah; Yusuke Okuno; Mikkael A. Sekeres; Seishi Ogawa; Jaroslaw P. Maciejewski
BLOOD, 124(21), 2014年12月

The Impact of Clonal Architecture of IDH1 and IDH2 Mutant Cases on the Biology of Myeloid Malignancies
Swapna Thota; Hideki Makishima; Bartlomiej P. Przychodzen; Aaron D. Viny; Bhumika J. Patel; Tomas Radivoyevitch; Mikkael A. Sekeres; Hetty E. Carraway; Torsten Haferlach; Seishi Ogawa; Jaroslaw P. Maciejewski
BLOOD, 124(21), 2014年12月

Different Genomic Patterns in Patients with Primary Acute Myeloid Leukemia (AML) Compared to Secondary AML in Patients with Normal Karyotype
Aziz Nazha; David J. Seastone; Priyanka A. Pophali; Tomas Radivoyevitch; Hetty E. Carraway; Anjali S. Advani; Matt E. Kalaycio; Gina Rupp; Kristin Colaluca; Bartlomiej P. Przychodzen; Hideki Makishima; Jaroslaw P. Maciejewski; Mikkael A. Sekeres
BLOOD, 124(21), 2014年12月

Bortezomib plus MEC (Mitoxantrone, Etoposide, Cytarabine) for Relapsed/Refractory Acute Myeloid Leukemia: Final Results of an Expanded Phase 1 Trial
Anjali S. Advani; Paul Elson; Matt E. Kalaycio; Sudipto Mukherjee; Aaron T. Gerds; Betty K. Hamilton; Sean Hobson; Arian Smith; Mary Lynn Rush; Samjhana Bogati; Monique Biggins; Eric D. Hsi; Hien K. Duong; Edward A. Copelan; Frederic J. Reu; Yogen Saunthararajah; Aziz Nazha; Hideki Makishima; Bartlomiej Przychodzen; Brittney Dienes; Jaroslaw P. Maciejewski; Jennifer S. Carew; Hetty E. Carraway; Mikkael A. Sekeres
BLOOD, 124(21), 2014年12月

Gfi136N As a Novel Marker and Therapeutic Target of MDS and AML
Lars C. Michel; Lacramioara Botezatu; Judith Maria Hoenes; Anna Marneth; Damien Grapton; Charles Vadnais; Ulrich Germing; Uwe Platzbecker; Thomas Schroeder; Rainer Haas; Bert A. van der Reijden; Gerhard Ehninger; Jaroslaw P. Maciejewski; Tomas Radivoyevitch; Andre Goergens; Bernd Giebel; Jan Fleckhaus; Hideki Makishima; Tarik Moroy; Ulrich Duehrsen; Cyrus Khandanpour
BLOOD, 124(21), 2014年12月

Multiple Mechanisms Leading to ARID2 defects in Myeloid Neoplasms
Hitoshi Sakai; Naoko Hosono; Bartlomiej P. Przychodzen; Hetty E. Carraway; Mikkael A. Sekeres; Jaroslaw P. Maciejewski; Hideki Makishima
BLOOD, 124(21), 2014年12月

Chronological Analysis of Clonal Evolution in Acquired Aplastic Anemia
Tetsuichi Yoshizato; Bogdan Dumitriu; Kohei Hosokawa; Hideki Makishima; Kenichi Yoshida; Aiko Sato; Yusuke Okuno; Keisuke Kataoka; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Yasunobu Nagata; Hiromichi Suzuki; Yusuke Sato; Yusuke Shiozawa; Takamasa Katagiri; Ayana Kon; Michael Clemente; Masashi Sanada; Satoru Miyano; Jaroslaw P. Maciejewski; Shinji Nakao; Neal S. Young; Seishi Ogawa
BLOOD, 124(21), 2014年12月

Chronic Myelomonocytic Leukemia (CMML) Can be Categorized By Ancestral Mutational Events
Bhumika J. Patel; Dayong Huang; Swapna Thota; Bartlomiej P. Przychodzen; Hirotoshi Sakaguchi; Seiji Kojima; Seishi Ogawa; Mikkael A. Sekeres; Hideki Makishima; Jaroslaw P. Maciejewski
BLOOD, 124(21), 2014年12月

Haploinsufficiency and Deletions of G3BP1 on Chromosome 5q Result in Induction of TP53
Naoko Hosono; Mahfouz Reda; Bartlomiej P. Przychodzen; Chantana Polprasert; Latifa Zekri; Michael J. Clemente; Jamal Tazi; Yogen Saunthararajah; Mikkael A. Sekeres; Jaroslaw P. Maciejewski; Hideki Makishima
BLOOD, 124(21), 2014年12月

Aberrant Hedgehog Pathway Activity Marks Clinical MDS Progression and Accelerates Leukemic Transformation in Vivo
Lukasz P. Gondek; Yiting Lim; Hideki Makishima; Qiuju Wang; Jaroslaw P. Maciejewski; Peter D. Aplan; Amy E. DeZern; William Matsui
BLOOD, 124(21), 2014年12月

GNB1 Activating Mutations Promote Myeloid and Lymphoid Neoplasms Targetable By Combined PI3K/mTOR Inhibition
Akinori Yoda; Guillaume Adelmant; Jerome Tamburini; Bjoern Chapuy; Nobuaki Shindoh; Yuka Yoda; Oliver Weigert; Nadja Kopp; Shuo-Chieh Wu; Sunhee S. Kim; Huiyun Liu; Trevor Tivey; Amanda L. Christie; Kutlu G. Elpek; Joseph Card; Kira Gritsman; Jason Gotlib; Michael W. Deininger; Hideki Makishima; Shannon Turley; Nathalie Javidi-Sharifi; Jaroslaw P. Maciejewski; Scott J. Rodig; Jeffrey W. Tyner; Jarrod A. Marto; David M. Weinstock; Andrew A. Lane
BLOOD, 124(21), 2014年12月

Distinct Pattern of Genomic Changes Associated with Hypoplastic Compared to Hyper/Normoblastic Myelodysplastic Syndromes (MDS)
Aziz Nazha; David J. Seastone; Tomas Radivoyevitch; Brittney Dienes; Bartlomiej Przychodzen; Sean Hobson; Sudipto Mukherjee; Hetty E. Carraway; Jennifer S. Carew; Anjali S. Advani; Aaron T. Gerds; Hideki Makishima; Mikkael A. Sekeres; Jaroslaw P. Maciejewski
BLOOD, 124(21), 2014年12月

Molecular Predictors of Response in Patients with Myeloid Neoplasms Treated with Lenalidomide
Chantana Polprasert; Tomas Radivoyevitch; Naoko Hosono; Hideki Makishima; Bartlomiej P. Przychodzen; Brittney Dienes; Kathy McGraw; Sudipto Mukherjee; Hetty E. Carraway; Mikkael A. Sekeres; Alan F. List; Jaroslaw P. Maciejewski
BLOOD, 124(21), 2014年12月

Impact and Function of Somatic PHF6 Mutations in Myeloid Neoplasms
Brittney Dienes; Bartlomiej P. Przychodzen; Michael Clemente; Wenyi Shen; Chantana Polprasert; Naoko Hosono; Satoru Miyano; Yuichi Shiraishi; Kenichi Yoshida; Seishi Ogawa; Mikkael A. Sekeres; Yogen Saunthararajah; Jaroslaw P. Maciejewski; Hideki Makishima
BLOOD, 124(21), 2014年12月

Analysis of Clonal Hierarchy Shows That Other Ancestral Events May Precede Evolution of Del(5q) in Myeloid Neoplasms
Naoko Hosono; Hideki Makishima; Bartlomiej P. Przychodzen; Thomas LaFramboise; Chantana Polprasert; Michael J. Clemente; Jacqueline Boultwood; Mikkael A. Sekeres; Jaroslaw P. Maciejewski
BLOOD, 124(21), 2014年12月

Germline DDX41 mutations constitute a novel AML syndrome with late onset
Schulze, I; C. Polprasert; M. Sekeres; H. Makishima; B. Przychodzen; N. Hosono; J. Singh; R. Padgett; J. Phillips; S. Mukherjee; M. Clemente; U. Krug; H-U Klein; M. Dugas; W. E. Berdel; K. Yoshida; Y. Shiraishi; K. Chiba; H. Tanaka; S. Miyano; S. Ogawa; C. Mueller-Tidow
ONCOLOGY RESEARCH AND TREATMENT, 37, 125-125, 2014年10月

GFI136N is a novel Prognostic Marker for the Progression of MDS to AML
L. Michel; L. Botezatu; J. Hoenes; A. Zeller; A. Marneth; D. Grapton; C. Vadnais; U. Germing; U. Platzbecker; T. Schroeder; R. Haas; B. van der Reijden; G. Ehninger; H. Makishima; J. Maciejewski; T. Moroy; U. Duehrsen; C. Khandanpour
ONCOLOGY RESEARCH AND TREATMENT, 37, 42-42, 2014年10月

GFI1 AS A NEW TARGET AND PREDICTIVE MARKER IN AML
Judith Hoenes; Lacramioara Botezatu; Lars Michel; Christian Thiede; Bert Reijden; Michael Heuser; Peter Valk; Bob Lowenberg; Hideki Makishima; Gerhard Ehninger; Ulrich Duehrsen; Jaroslaw Maciejewski; Tarik Moeroey; Cyrus Khandanpour
EXPERIMENTAL HEMATOLOGY, 42(8), S20-S20, 2014年08月

GFI136N IS A PROGNOSTIC MARKER AND POSSIBLE TARGET FOR THE PROGRESSION OF MDS TO AML
Lars Miche; Lacramioara Botezatu; Judith Hoenes; Damien Grapton; Charles Vadnais; Ulrich Germing; Thomas Schroeder; Rainer Haas; Uwe Platzbecker; Gerhard Ehninger; Hideki Makishima; Anne Marneth; Jaroslaw Maciejewski; Tank Moeroey; Bert Reijden; Ulrich Duehrsen; Cyrus Khandanpour
EXPERIMENTAL HEMATOLOGY, 42(8), S42-S42, 2014年08月

CHRONOLOGICAL ANALYSIS OF CLONAL EVOLUTION IN ACQUIRED APLASTIC ANEMIA
T. Yoshizato; K. Hosokawa; H. Makishima; K. Yoshida; Y. Okuno; K. Chiba; H. Tanaka; Y. Shiraishi; Y. Nagata; T. Katagiri; A. Kon; M. Clemente; M. Sanada; S. Miyano; S. Nakao; J. Maciejewski; S. Ogawa
HAEMATOLOGICA, 99, 261-261, 2014年06月

STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients (vol 122, pg 2453, 2013)
A. Jerez; M. J. Clemente; H. Makishima
BLOOD, 123(21), 3364-3364, 2014年05月

Escape of EML4-ALK NSCLC to early phase precision therapy through TGF beta 2-HOX-bioenergetics reprogramming.
Lihong Yin; Wei Zhang; Ivy Shi; Yan Feng; Humberto Choi; Rakesh K. Bagel; Hideki Makishima; Christopher Lanlgan; Joseph Clcenla; Thomas Glidea; Wel-Li Liao; Todd A. Hembrough; Jon Burrows; Raymond R. Tubbs; Daniel Lindner; Francisco Almeida; Jaroslaw P. Maciejewski; Patrick C. Ma
JOURNAL OF CLINICAL ONCOLOGY, 32(15), 2014年05月

Somatic spliceosomal factor mutations in bone marrow neoplasms — downstream effects and mechanistic insights
Richard Padgett; Rosemary Dietrich; Jarnail Singh; Bartlomiej Przychodzen; Hideki Makishima; Jaroslaw Maciejewski
FASEB JOURNAL, 28(1), 2014年04月

Clinical and Genetic Characterization Of Patients With C-CBL Mutated Juvenile Myelomonocytic Leukemia By whole-Exome/Deep Sequencing
Hideki Muramatsu; Hirotoshi Sakaguchi; Xinan Wang; Kenichi Yoshida; Yusuke Okuno; Masashi Sanada; Yinyan Xu; Sayoko Doisaki; Atsushi Narita; Nozomu Kawashima; Asahito Hama; Yoshiyuki Takahashi; Nao Yoshida; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Hideki Makishima; Jaroslaw P. Maciejewski; Satoru Miyano; Seishi Ogawa; Seiji Kojima
BLOOD, 122(21), 2013年11月

Aberrant DNA Methylation Is Associated With Poor Outcomes In Juvenile Myelomonocytic Leukemia
Hirotoshi Sakaguchi; Hideki Muramatsu; Xinan Wang; Yinyan Xu; Yoko Hibi; Nozomu Kawashima; Atsushi Narita; Sayoko Doisaki; Nao Yoshida; Asahito Hama; Yoshiyuki Takahashi; Hideki Makishima; Kiyofumi Yamada; Jaroslaw P. Maciejewski; Seiji Kojima
BLOOD, 122(21), 2013年11月

The Presence Of Leukemogenic Mutational Events In Paroxysmal Nocturnal Hemoglobinuria Suggests That Clonal Architecture Of Bone Marrow Failure Is Similar To Myelodysplastic Syndrome
Wenyi Shen; Bartlomiej P. Przychodzen; Michael J. Clemente; Brittney Dienes; Tetsuichi Yoshisato; Masashi Sanada; Kenichi Yoshida; Seishi Ogawa; Jaroslaw P. Maciejewski; Hideki Makishima
BLOOD, 122(21), 2013年11月

SQSTM1/p62 Is a Necessary Cofactor In MDS/AML With Deletion Of Mir-146a
Jing Fang; Brenden Barker; Lyndsey Bolanos; Xiaona Liu; Andres Jerez; Hideki Makishima; Dinesh S. Rao; James C. Mulloy; Jaroslaw P. Maciejewski; Jose A. Cancelas; Daniel T. Starczynowski
BLOOD, 122(21), 2013年11月

Molecular Predictors Of Response To Lenalidomide In Myeloid Malignancies
Zaher K. Otrock; Bartlomiej P. Przychodzen; Holleh D. Husseinzadeh; Hideki Makishima; Brittney Dienes; Naoko Hosono; Mikkael A. Sekeres; Jaroslaw P. Maciejewski
BLOOD, 122(21), 2013年11月

Spliceosomal Gene LUC7L2 Mutation Causes Missplicing and Alteration Of Gene Expression In Myeloid Neoplasms
Naoko Hosono; Hideki Makishima; Bartlomiej Przychodzen; Jarnail Singh; Richard A. Padgett; Mikkael A. Sekeres; Andres Jerez; Kenichi Yoshida; Yuichi Shiraishi; Satoru Miyano; Masashi Sanada; Seishi Ogawa; Jaroslaw P. Maciejewski
BLOOD, 122(21), 2013年11月

Clinical "MUTATOME" Of Myelodysplastic Syndrome; Comparison To Primary Acute Myelogenous Leukemia
Hideki Makishima; Thomas LaFramboise; Bartlomiej P. Przychodzen; Kenichi Yoshida; Matthew Ruffalo; Ines Gomez-Segui; Holleh D. Husseinzadeh; Yuichi Shiraishi; Masashi Sanada; Yasunobu Nagata; Yusuke Sato; Aiko Sato-Otsubo; Kenichi Chiba; Hiroko Tanaka; Tsuyoshi Nakamaki; Wolf-Karsten Hofmann; Shuichi Miyawaki; Lee-Yung Shih; Shigeru Chiba; Satoru Miyano; Naoko Hosono; Chantana Polprasert; Swapna Thota; Brittney Dienes; Kathryn M. Guinta; Yogen Sauntharatajah; Mikkael A. Sekeres; Seishi Ogawa; Jaroslaw P. Maciejewski
BLOOD, 122(21), 2013年11月

Somatic Mutations and Loss-Of-Heterozygosity Impair The DNA Repair Functions Of CUX1 in Myelodysplastic Syndromes (MDS)
Naoko Hosono; Zubaidah M. Ramdzan; Ranjana Pal; Hideki Makishima; Bartlomiej P. Przychodzen; Mikkael A. Sekeres; Kenichi Yoshida; Yuichi Shiraishi; Satoru Miyano; Seishi Ogawa; Alain Nepveu; Jaroslaw P. Maciejewski
BLOOD, 122(21), 2013年11月

Molecular Defects In BRCC3 Complex, a Novel Pathogenic Pathway In MDS
Dayong Huang; Hideki Makishima; Yang Du; Naoko Hosono; Wenyi Shen; Chantana Polprasert; Mikkael A. Sekeres; Bartlomiej Przychodzen; Richard A. Padgett; Jarnail Singh; Kathryn M. Guinta; Michael J. Clemente; Brittney Dienes; Manuel Afable; Holleh D. Husseinzadeh; Sarah Mcmahon; Yogen Saunthararajah; Kenichi Yoshida; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Seishi Ogawa; Jaroslaw P. Maciejewski
BLOOD, 122(21), 2013年11月

Whole Exome Sequencing Detecting Kinesin Family Gene Defects In Myeloid Neoplasm
Chantana Polprasert; Hideki Makishima; Bartlomiej P. Przychodzen; Naoko Hosono; Wenyi Shen; Dayong Huang; Yuichi Shiraishi; Satoru Miyano; Kenichi Yoshida; Seishi Ogawa; Jaroslaw P. Maciejewski
BLOOD, 122(21), 2013年11月

Somatic Mutational Screen For Improved Prediction Of The Outcomes Of Epigenetic Therapy In MDS
Swapna Thota; Paul Lakin; Holleh Husseinzadeh; Hideki Makishima; Bartlomiej P. Przychodzen; Brittney Dienes; Kathryn M. Guinta; Naoko Hosono; Tomas Radivoyevitch; Mikkael A. Sekeres; Yogen Saunthararajah; Jaroslaw P. Maciejewski
BLOOD, 122(21), 2013年11月

Germline Events In GFI1 In Myelodysplastic Syndrome
Swapna Thota; Sarah McMahon; Hideki Makishima; Bartlomiej P. Przychodzen; Kathryn M. Guinta; Brittney Dienes; Naoko Hosono; Mikkael A. Sekeres; Jaroslaw P. Maciejewski
BLOOD, 122(21), 2013年11月

Novel Pathogenic Defects Of Dead/H-Box Helicases In Myeloid Neoplasms
Chantana Polprasert; Mikkael A. Sekeres; Hideki Makishima; Bartlomiej P. Przychodzen; Naoko Hosono; Richard A. Padgett; Jarnail Singh; Otrock Zaher; Sudipto Mukherjee; Manuel G. Afable; Holleh D. Husseinzadeh; Sarah Mcmahon; Wenyi Shen; Dayong Huang; Kenichi Yoshida; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Seishi Ogawa; Jaroslaw P. Maciejewski
BLOOD, 122(21), 2013年11月

Distinct Pattern Of Genomic Changes Associated With Smoking In Patients With Myelodysplastic Syndromes (MDS)
David J. Seastone; Sudipto Mukherjee; Zaher K. Otrock; Paul Elson; Michael K. Keng; Bartlomiej Przychodzen; Hideki Makishima; Brittney Dienes; Sean Hobson; Kristin Dodd; Tracy Cinalli; Ramon V. Tiu; Yogen Saunthararajah; Jaroslaw P. Maciejewski; Mikkael A. Sekeres
BLOOD, 122(21), 2013年11月

Whole Exome Analysis Of Germline Alterations Associated With Myelodysplastic Syndrome
Sarah McMahon; Bartlomiej P. Przychodzen; Hideki Makishima; Thomas LaFramboise; Kenichi Yoshida; Yuichi Shiraishi; Masashi Sanada; Yasunobu Nagata; Yusuke Sato; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Aiko Sato-Otsubo; Seishi Ogawa; Jaroslaw P. Maciejewski
BLOOD, 122(21), 2013年11月

Clinical and Genetic Characterization Of Patients With C-CBL Mutated Juvenile Myelomonocytic Leukemia By Whole-Exome/Deep Sequencing
Hideki Muramatsu; Hirotoshi Sakaguchi; Xinan Wang; Kenichi Yoshida; Yusuke Okuno; Masashi Sanada; Yinyan Xu; Sayoko Doisaki; Atsushi Narita; Nozomu Kawashima; Asahito Hama; Yoshiyuki Takahashi; Nao Yoshida; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Hideki Makishima; Jaroslaw P. Maciejewski; Satoru Miyano; Seishi Ogawa; Seiji Kojima
BLOOD, 122(21), 2013年11月

Spectrum Of Genetic Alterations In Acquired Aplastic Anemia
Tetsuichi Yoshizato; Bogdan Dumitriu; Kohei Hosokawa; Hideki Makishima; Kenichi Yoshida; Yusuke Okuno; Kenichi Chiba; Hiroko Tanaka; Yuichi Shiraishi; Yasunobu Nagata; Takamasa Katagiri; Ayana Kon; Michael J. Clemente; Masashi Sanada; Satoru Miyano; Jaroslaw P. Maciejewski; Shinji Nakao; Neal S. Young; Seishi Ogawa
BLOOD, 122(21), 2013年11月

Comprehensive Identification Of Germline Alterations In Telomerase Complex Genes By Whole Exome Sequencing Of MDS and Related Myeloid Neoplasms
Swapna Thota; Sarah McMahon; Bartlomiej Przychodzen; Thomas LaFramboise; Hideki Makishima; Mikkael A. Sekeres; Jaroslaw P. Maciejewski
BLOOD, 122(21), 2013年11月

NOVEL NRAS GENE MUTATION IN A 2 YEAR OLD CHILD WITH JMML AND T-CELL NHL
Arunkumar Modi; Hideki Makishima; Kate Gowans; Jaroslaw Maiejewski; Rabi Hanna
PEDIATRIC BLOOD & CANCER, 60, S55-S55, 2013年06月

Novel mutations in spliceosomal gene PRPF8 show ring sideroblast phenotype in patients with myeloid neoplasms
A. Kozaric; H. Makishima; B. Przychodzen; J. Singh; S. Ogawa; K. Yoshida; M. Nakishima; Z. K. Otrock; E. Hsi; R. A. Padgett; J. P. Maciejewski
LEUKEMIA RESEARCH, 37, S36-S36, 2013年05月

Next generation whole exome sequencing for recurrent somatic mutations on chromosome 7
N. Hosono; H. Makishima; A. Jerez; B. Przychodzen; I. Gomez-Segui; M. Sekeres; S. Miyano; Y. Shiraishi; S. Ogawa; K. Yoshida; J. P. Maciejewski
LEUKEMIA RESEARCH, 37, S23-S23, 2013年05月

Overlap of BMF and MDS
J. Maciejewski; H. Makishima; N. Hosono; M. Afable; H. Husseinzadeh; A. Jerez; W. Shen; M. Clemente; M. Sekeres
LEUKEMIA RESEARCH, 37, S4-S5, 2013年05月

Translational significance of a newly identified hepatocellular carcinoma tumor suppressor gene on chromosome 8p.
Han Chong Toh; Francis Enane; Marissa Teo; Hideki Makishima; JoAnna Ng; Chit Lai Chee; Soo Fan Ang; Kiat Hon Lim; Yogen Saunthararajah
JOURNAL OF CLINICAL ONCOLOGY, 31(15), 2013年05月

Clinical and genetic characterization of 17 juvenile myelomonocytic leukemia patients with c-CBL mutations
H. Muramatsu; H. Sakaguchi; Y. Xu; K. Yoshida; Y. Okuno; A. Hama; Y. Takahashi; H. Makishima; J. P. Maciejewski; S. Ogawa; S. Kojima
LEUKEMIA RESEARCH, 37, S89-S89, 2013年05月

Frequent mutation and deletion of GATA4 in hepatocellular carcinoma represses proliferation terminating late-maturation genes CEBPD and HNF4A by reversible epigenetic mechanisms
Francis O. Enane; Marissa Teo; Hideki Makishima; Zhenbo Hu; Han Chong Toh; Yogen Saunthararajah; Joanna Ng; Chit Lai; Soo Fan Ang; Lim Kiat Hon
CANCER RESEARCH, 73(8), 2013年04月

血液腫瘍における遺伝子変異
牧島 秀樹
信州医学雑誌 = The Shinshu medical journal, 61(3), 129-138, 2013年

Downstream Consequences of U2AF1 Mutations in MDS Are a Result of a Specific Misplicing Patterns Due to Faulty Recognition of 3 ' acceptor Splice Site
Bartlomiej P. Przychodzen; Hideki Makishima; Andres Jerez; Richard A. Padgett; Jaroslaw P. Maciejewski
BLOOD, 120(21), 2012年11月

Mutation Screening Associated with Chromosome 7 Abnormalities Using Next Generation Whole Exome Sequencing
Naoko Hosono; Hideki Makishima; Andres Jerez; Ines Gomez-Segui; Bartlomiej Przychodzen; Mikkael A. Sekeres; Satoru Miyano; Yuichi Shiraishi; Seishi Ogawa; Jaroslaw P. Maciejewski
BLOOD, 120(21), 2012年11月

Biological Rationale for the Favorable Clinical Outcomes of Patients Carrying SF3B1 Mutations in Myelodysplastic Syndromes with Ring Sideroblasts
Valeria Visconte; Reda Z. Mahfouz; Ali Tabarroki; Heesun J. Rogers; Bodo Juraj; Edy Hasrouni; Reza Sharghi-Moshtaghin; Nanthawan Avishai; Manoj Bupathi; Betty K. Hamilton; Yang Liu; Hideki Makishima; Anna Jankowska; John Barnard; Fabiola Traina; Yogen Saunthararajah; Edward A. Copelan; Arthur Heuer; Daniel Lindner; Jaroslaw P. Maciejewski; Mikkael A. Sekeres; Ramon V. Tiu
BLOOD, 120(21), 2012年11月

Molecular Diversity Detected by Whole Exome Sequencing in Chronic Myelomonocytic Leukemia
Edward P. Evans; Satoru Miyano; Yasunobu Nagata; Yuichi Shiraishi; Kenichi Chiba; Masashi Sanada; Bartlomiej P. Przychodzen; Ines Gomez-Segui; Kathryn M. Guinta; Manuel G. Afable; Yogen Saunthararajah; Mikkael A. Sekeres; Jaroslaw P. Maciejewski; Seishi Ogawa; Hideki Makishima
BLOOD, 120(21), 2012年11月

Whole Exome Analysis Reveals Spectrum of Gene Mutations in Juvenile Myelomonocytic Leukemia
Hideki Muramatsu; Yusuke Okuno; Hirotoshi Sakaguchi; Kenichi Yoshida; Yuichi Shiraishi; Masashi Sanada; Kenichi Chiba; Hiroko Tanaka; Hideki Makishima; Xinan Wang; Yinyan Xu; Sayoko Doisaki; Asahito Hama; Koji Nakanishi; Yoshiyuki Takahashi; Nao Yoshida; Jaroslaw P. Maciejewski; Satoru Miyano; Seishi Ogawa; Seiji Kojima
BLOOD, 120(21), 2012年11月

Somatic Mutations in Schinzel-Giedion Syndrome Gene SETBP1 Determine Progression in Myeloid Malignancies
Hideki Makishima; Kenichi Yoshida; Nhu Nguyen; Masashi Sanada; Yusuke Okuno; Kwok Peng Ng; Bartlomiej P. Przychodzen; Kristbjorn O. Gudmundsson; Bandana A. Vishwakarma; Andres Jerez; Ines Gomez-Segui; Mariko Takahashi; Yuichi Shiraishi; Yasunobu Nagata; Kathryn M. Guinta; Hiraku Mori; Mikkael A. Sekeres; Kenichi Chiba; Hideki Muramatsu; Hirotoshi Sakaguchi; Ronald Paquette; Michael A. McDevitt; Seiji Kojima; Yogen Saunthararajah; Satoru Miyano; Lee-Yung Shih; Yang Du; Seishi Ogawa; Jaroslaw P. Maciejewski
BLOOD, 120(21), 2012年11月

Whole Exome Sequencing to Predict Response to Hypomethylating Agents in MDS
Holleh D. Husseinzadeh; Edward P. Evans; Kenichi Yoshida; Hideki Makishima; Andres Jerez; Matthew Ruffalo; Yuichi Shiraishi; Satoru Miyano; Masashi Sanada; Kenichi Chiba; Yasunobu Nagata; Ines Gomez-Segui; Bartlomiej P. Przychodzen; Candice Wenzell; Manuel G. Afable; Yogen Saunthararajah; Anjali Advani; Mikkael A. Sekeres; Seishi Ogawa; Jaroslaw P. Maciejewski
BLOOD, 120(21), 2012年11月

Identification and Monitoring of Pathogenic T Cell Clones Using Deep TCR Sequencing in T-Large Granular Lymphocyte Leukemia and Aplastic Anemia
Michael J. Clemente; Bartlomiej Przychodzen; Hideki Makishima; Manuel G. Afable; Marcin W. Wlodarski; Alan E. Lichtin; Jaroslaw P. Maciejewski
BLOOD, 120(21), 2012年11月

Molecular Mutations in U2AF1 Are Most Commonly Found in Del20q Myelodysplastic Syndromes but Do Not Lead to Poor Prognosis in This Karyotypic Subtype
Ali Tabarroki; Li Zhang; Valeria Visconte; Manoj Bupathi; Heesun J. Rogers; Hideki Makishima; Fabiola Traina; Betty K. Hamilton; Edy Hasrouni; Michael J. Clemente; Paula de Melo Campos; Hien K. Duong; Anjali Advani; Mikkael A. Sekeres; Edward A. Copelan; Ramon V. Tiu
BLOOD, 120(21), 2012年11月

Karyotypic and Genetic Abnormalities Associated with Clonal Evolution in Paroxysmal Nocturnal Hemoglobinuria
Hideki Makishima; Kenichi Yoshida; Michael J. Clemente; Masashi Sanada; Yasunobu Nagata; Manuel G. Afable; Andres Jerez; Kenichi Chiba; Yuichi Shiraishi; Satoru Miyano; Seishi Ogawa; Jaroslaw P. Maciejewski
BLOOD, 120(21), 2012年11月

Various Germline Congenital Disorder Genes Are Somatically Mutated in Myeloid Malignancies
Naoko Hosono; Hasan Rehman; Bartlomiej Przychodzen; Ines Gomez-Segui; Kathryn M. Guinta; Kenichi Yoshida; Satoru Miyano; Yuichi Shiraishi; Seishi Ogawa; Jaroslaw P. Maciejewski; Hideki Makishima
BLOOD, 120(21), 2012年11月

Pathway Analysis of Molecular Mutations Can Modify Morphologic, Cytogenetic and Prognostic Risk Stratification Schemes in Myelodysplastic Syndromes (MDS), Myelodysplastic Syndromes/Myeloproliferative Neoplasms (MDS/MPN), and Secondary Acute Myeloid Leukemia (AML)
Edy Hasrouni; Valeria Visconte; Ali Tabarroki; Heesun J. Rogers; Fabiola Traina; Anna Jankowska; Yang Liu; Betty K. Hamilton; Manoj Bupathi; Hideki Makishima; Andres Jerez; Edward A. Copelan; Anjali Advani; Michael A. McDevitt; Matt Kalaycio; Yogen Saunthararajah; Mikkael A. Sekeres; Jaroslaw P. Maciejewski; Ramon V. Tiu
BLOOD, 120(21), 2012年11月

Molecular Diversity Detected by Whole Exome Sequencing in Chronic Myelomonocytic Leukemia
Basel Rouphail; Kenichi Yoshida; Holleh D. Husseinzadeh; Edward P. Evans; Satoru Miyano; Yasunobu Nagata; Yuichi Shiraishi; Kenichi Chiba; Masashi Sanada; Bartlomiej P. Przychodzen; Ines Gomez-Segui; Kathryn M. Guinta; Manuel G. Afable; Yogen Saunthararajah; Mikkael A. Sekeres; Jaroslaw P. Maciejewski; Seishi Ogawa; Hideki Makishima
BLOOD, 120(21), 2012年11月

STAT3 Gene Mutations and the Association with Pure Red Cell Aplasia in Large Granular Lymphocyte Leukemia.
Nodoka Sekiguchi; Kazuyuki Matsuda; Kayoko Momose; Hideki Makishima; Toshiro Ito; Fumihiro Ishida
BLOOD, 120(21), 2012年11月

Impact of Mutations in the Spliceosome Machinery and Ring Sideroblasts in Patients with Myeloid Malignancies Who Received Conventional Chemotherapy or Allogeneic Hematopoietic Cell Transplantation
Betty K. Hamilton; Ali Tabarroki; Valeria Visconte; Edy Hasrouni; Hideki Makishima; Shawnda Tench; Matt Kalaycio; Mikkael A. Sekeres; Ronald Sobecks; Hien K. Duong; Brian T. Hill; Jaroslaw P. Maciejewski; Brian J. Bolwell; Edward A. Copelan; Ramon V. Tiu
BLOOD, 120(21), 2012年11月

Mutational Spectrum of Myelodysplastic Syndrome Malignancies Revealed by Whole Exome Sequencing
Ines Gomez-Segui; Bartlomiej P. Przychodzen; Kenichi Yoshida; Matthew Ruffalo; Andres Jerez; Hideki Makishima; Satoru Miyano; Yuichi Shiraishi; Holleh D. Husseinzadeh; Edward P. Evans; Naoko Hosono; Kathryn M. Guinta; Thomas LaFramboise; Seishi Ogawa; Yogen Saunthararajah; Mikkael A. Sekeres; Jaroslaw P. Maciejewski
BLOOD, 120(21), 2012年11月

Biological Rationale for the Favorable Clinical Outcomes of Patients Carrying SF3B1 Mutations in Myelodysplastic Syndromes with Ring Sideroblasts
Valeria Visconte; Reda Z. Mahfouz; Ali Tabarroki; Heesun J. Rogers; Bodo Juraj; Edy Hasrouni; Reza Sharghi-Moshtaghin; Nanthawan Avishai; Manoj Bupathi; Betty K. Hamilton; Yang Liu; Hideki Makishima; Anna Jankowska; John Barnard; Fabiola Traina; Yogen Saunthararajah; Edward A. Copelan; Arthur Heuer; Daniel Lindner; Jaroslaw P. Maciejewski; Mikkael A. Sekeres; Ramon V. Tiu
BLOOD, 120(21), 2012年11月

Mutational Spectrum of Myelodysplastic Syndrome Malignancies Revealed by Whole Exome Sequencing
Ines Gomez-Segui; Bartlomiej P. Przychodzen; Kenichi Yoshida; Matthew Ruffalo; Andres Jerez; Hideki Makishima; Satoru Miyano; Yuichi Shiraishi; Holleh D. Husseinzadeh; Edward P. Evans; Naoko Hosono; Kathryn M. Guinta; Thomas LaFramboise; Seishi Ogawa; Yogen Saunthararajah; Mikkael A. Sekeres; Jaroslaw P. Maciejewski
BLOOD, 120(21), 2012年11月

Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia (vol 118, pg 4384, 2011)
M. J. Clemente; M. W. Wlodarski; H. Makishima
BLOOD, 120(9), 1963-1963, 2012年08月

Impact of Molecular Mutations on Treatment Response to Hypomethylating Agents in MDS
Fabiola Traina; Anna M. Jankowska; Valeria Visconte; Yuka Sugimoto; Hadrian Szpurka; Hideki Makishima; Andres Jerez; Christine L. O'Keefe; Mikkael A. Sekeres; Anjali S. Advani; Yogen Saunthararajah; Matt Kalaycio; Edward A. Copelan; Sara T. Olalla Saad; Jaroslaw P. Maciejewski; Ramon V. Tiu
BLOOD, 118(21), 213-214, 2011年11月

T Cell Receptor Repertoire Landscape Mapping: A Novel Paradigm for T Cell Mediated Autoimmune Disorders Based on Deep V beta Chain Sequencing
Michael J. Clemente; Bartlomiej Przychodzen; Hideki Makishima; Manuel G. Afable; Alan E. Lichtin; Jaroslaw P. Maciejewski
BLOOD, 118(21), 590-591, 2011年11月

Association of SF3B1 with Ring Sideroblasts in patients, In Vivo, and In Vitro models of Spliceosomal Dysfunction
Valeria Visconte; Hideki Makishima; Anna M. Jankowska; Fabiola Traina; Hadrian Szpurka; Heesun J. Rogers; Andres Jerez; Christine L. O'Keefe; Sara Cohen Slatkin; Manoj Bupathi; Kathryn M. Guinta; Michael J. Clemente; Yogen Saunthararajah; Anjali S. Advani; Matt Kalaycio; Haruhiko Koseki; Kyoichi Isono; Jarnail Singh; Richard A. Padgett; Mikkael A. Sekeres; Jaroslaw P. Maciejewski; Ramon V. Tiu
BLOOD, 118(21), 211-212, 2011年11月

Mass Screening for Non-Synonymous SNPs Using Custom Cancer Microarrays Directly Reveals Possible Pathogenic Predisposition Factors in AA
Bartlomiej P. Przychodzen; Andres Jerez; Hideki Makishima; Kathryn M. Guinta; Peter Chomczynski
BLOOD, 118(21), 587-588, 2011年11月

The Impact of Molecular Lesions in Post-Transplant Acute Myeloid Leukemia (AML) in Correlation with Cytogenetic Abnormalities
Nelli Bejanyan; Brian J. Bolwell; Edward A. Copelan; Lisa Rybicki; Hideki Makishima; Andres Jerez; Hirotoshi Sakaguchi; Kathryn M. Guinta; Christine L. O'Keefe; Nolyn Nyatanga; Shawnda Tench; Anjali S. Advani; Mildcael A. Sekeres; Matt Kalaycio; Eric D. Hsi; Jaroslaw P. Maciejewski
BLOOD, 118(21), 1769-1769, 2011年11月

Mechanisms of Defective Hydroxylation of 5-Methylcytosine in MDS Include Pathways Other Than TET2 and IDH1/2
Anna M. Jankowska; Yun Huang; Myunggon Ko; Utz J. Pape; Hideki Makishima; Hadrian Szpurka; Fabiola Traina; Valeria Visconte; Ramon V. Tiu; Mikkael A. Sekeres; Anjana Rao; Jaroslaw P. Maciejewski
BLOOD, 118(21), 214-214, 2011年11月

Clinical and Genomic Characterization of Chromosome 7 Lesions in Myeloid Malignancies
Andres Jerez; Yuka Sugimoto; Hideki Makishima; Amit Verma; Christine L. O'Keefe; Ramon V. Tiu; Aziin M. Moharnedali; Michael A. McDevitt; Ghulam J. Mufti; Jacqueline Boultwood; Jaroslaw P. Maciejewsik
BLOOD, 118(21), 1515-1515, 2011年11月

Defining the Topography of Deletion 5q Using SNP-A Identifies Patients with More Aggressive Disease and Correlates with Additional Lesions
Andres Jerez; Anna M. Jankowska; Hideki Makishima; Lukasz P. Gondek; Ramon V. Tiu; Christine L. O'Keefe; Azim M. Mohamedali; Denise Batista; Michael A. McDevitt; Mikkael A. Sekeres; Ghulam J. Mufti; Jaroslaw P. Maciejewski
BLOOD, 118(21), 1205-1205, 2011年11月

Pathogenesis of MONOSOMY 7 In BONE MARROW FAILURE SYNDROMES
Hideki Makishima; Fabiola Traina; Anna M. Jankowska; Yuka Sugimoto; Kathryn M. Guinta; Hirotoshi Sakaguchi; Christine L. O'Keefe; Hideki Muramatsu; Seiji Kojima; Jaroslaw P. Maciejewski
BLOOD, 118(21), 1037-1037, 2011年11月

Distinction of Early and Late Molecular Events In Patients with Myelodysplastic Syndromes (MDS) Who Progressed to Acute Myeloid Leukemia (AML)
Manuel G. Afable; Hideki Makishima; Hirotoshi Sakaguchi; Andres Jerez; Anna Malgorzata Jankowska; Kathryn M. Guinta; Sara Abu Kar; Fabiola Traina; Yuka Sugimoto; Christine O'Keefe; Ramon V. Tiu; Mikkael A. Sekers; Jaroslaw P. Maciejewski
BLOOD, 118(21), 1522-1523, 2011年11月

Acquired Molecular Defects in Spliceosome Machinery: Novel Pathogenetic Pathways in Myeloid Leukemogenesis
Hideki Makishima; Hirotoshi Sakaguchi; Valeria Visconte; Andres Jerez; Anna M. Jankowska; Kathryn M. Guinta; Hideki Muramatsu; Mikkael A. Sekeres; Seiji Kojima; Ramon V. Tiu; Jaroslaw P. Maciejewski
BLOOD, 118(21), 125-125, 2011年11月

EZH2 Is Either Mutated or Downregulated in Patients with Loss of Heterozygosity of Chromosome 7/7q and Leads to Epigenetic Dysregulation Via Histone H3K27
Hideki Makishima; Shahper N. Khan; Anna M. Jankowska; Yuka Sugimoto; Zhenbo Hu; Venugopalan Cheriyath; Reda Mahfouz; Quteba Ebrahem; Sergei Vatolin; Yogen Saunthararajah; Mikkael A. Sekeres; Jaroslaw P. Maciejewski
BLOOD, 118(21), 104-105, 2011年11月

Spliceosome GENE MUTATIONS ARE Also PRESENT In the Diverse Mutational Spectrum of CHRONIC Myelomonocytic LEUKEMIA
Hideki Makishima; Anna M. Jankowska; Valeria Visconte; Ramon V. Tiu; Kathryn M. Guinta; Hadrian Szpurka; Yuka Sugimoto; Christine L. O'Keefe; Alan F. List; Mikkael A. Sekeres; Michael A. McDevitt; Jaroslaw P. Maciejewski
BLOOD, 118(21), 611-612, 2011年11月

Next Generation Exome Sequencing for Identification of the Gene Mutations Associated with Loss of Heterozygozity on Chromosome 7 In Myeloid Malignancies
Yuka Sugimoto; Hideki Makishima; Hadrian Szpurka; Anna Jankowska; Kathryn Guinta; Ramon V. Tiu; Christine L. O'Keefe; Alison R. Moliterno; Michael A. McDevitt; Hideki Muramatsu; Seiji Kojima; Mehdi Keddache; Jaroslaw Maciejewski
BLOOD, 116(21), 134-135, 2010年11月

A High Resolution Analysis of Chromosome 21 Amplification In Myeloid Malignancies Reveals An Association with a Specific Cytogenetic Subgroup and Enhanced ERG Gene Expression.
Hideki Makishima; Hideki Muramatsu; Asahito Hama; Ramon V. Tiu; Yuka Sugimoto; Mikkael A. Sekeres; Yogen Saunthararajah; Michael A. McDevitt; Seiji Kojima; Jaroslaw P. Maciejewski
BLOOD, 116(21), 707-707, 2010年11月

New TET2, ASXL1 and CBL Mutations Have Poor Prognostic Impact In Systemic Mastocytosis and Related Disorders
Fabiola Traina; Ania Jankowska; Hideki Makishima; Fred H. Hsieh; Yingchun Han; Christine O'Keefe; Yuka Sugimoto; Sanjay R. Mohan; Hadrian Szpurka; Courtney Prince; Kathryn Guinta; Mikkael A. Sekeres; Matt Kalaycio; Alan E. Lichtin; Anjali S. Advani; Edward Copelan; Ronald Sobecks; Jaroslaw P. Maciejewski; Ramon V. Tiu
BLOOD, 116(21), 1268-1269, 2010年11月

Profiles of Cytotoxic Molecules In Mature NK Cell Neoplasms
Nodoka Sekeguchi; Naoko Asano; Hideki Makishima; Masanobu Momose; Toshiro Ito; Shigeo Nakamura; Fumihiro Ishida
BLOOD, 116(21), 1685-1685, 2010年11月

Mutational Spectrum In Chronic Myelomonocytic Leukemia Includes Genes Associated with Epigenetic Regulation Such as UTX and EZH2
Anna Jankowska; Hideki Makishima; Ramon V. Tiu; Hadrian Szpurka; Yun Huang; Yuka Sugimoto; Courtney Prince; Christine L. O'Keefe; Eric Hsi; Alan F. List; Mikkael A. Sekeres; Anjana Rao; Michael A. McDevitt; Jaroslaw P. Maciejewski
BLOOD, 116(21), 268-269, 2010年11月

Identification of Oncogenic EZH2 Mutations In Myelodysplastic Syndromes and Related Myeloid Malignancies
Hideki Makishima; Ania Jankowska; Ramon V. Tiu; Hadrian Szpurka; Yuka Sugimoto; Quteba Ebrahem; Zhenbo Hu; Reda Mahfouz; Yogen Saunthararajah; Kathryn Guinta; Mehdi Keddache; Christine L. O'Keefe; Mikkael A. Sekeres; Alan F. List; Michael A. McDevitt; Jaroslaw P. Maciejewski
BLOOD, 116(21), 267-267, 2010年11月

Gene Alterations In Acute Megakaryoblastic Leukemia (AMKL): a Comparison of AMKL with and without Down Syndrome
Asahito Hama; Hideki Makishima; Hideki Muramatsu; Yuka Sugimoto; Sayoko Doisaki; Akira Shimada; Yoshiyuki Takahashi; Hitoshi Kiyoi; Seiji Kojima; Jaroslaw P. Maciejewski
BLOOD, 116(21), 383-383, 2010年11月

Various Abnormalities at Chromosome 7 Carry Distinct Biologic and Prognostic Implications In Myelodysplastic/Myeloproliferative Syndromes and Related Marrow Failures
Aaron D. Viny; Bartlomiej Przychodzen; Christine L. O'Keefe; Hideki Makishima; Yuka Sugimoto; Sanjay R. Mohan; Marcin W. Wlodarski; Seiji Kojima; Mikkael A. Sekeres; Jaroslaw P. Maciejewski
BLOOD, 116(21), 1132-1132, 2010年11月

Clonotype Switching Indicates Propensity for Clonal Outgrowth From Diverse Components of the T Cell Repertoire In T Cell Large Granular Lymphocyte Leukemia
Michael J. Clemente; Marcin W. Wlodarski; Aaron D. Viny; Mohammed Shaik; Nelli Bejanyan; Sanjay R. Mohan; Hideki Makishima; Alan E. Lichtin; Eric D. Hsi; Ronald L. Paquette; Thomas P. Loughran; Jaroslaw P. Maciejewski
BLOOD, 116(21), 504-505, 2010年11月

SNP-A Karyotyping Provides Clinically Relevant Results In Myeloid Hematologic Disorders with Unsuccessful Routine Cytogenetic Testing
Kathryn M. Guinta; Hideki Makishima; Christine L. O'Keefe; Simon Dujardin; Ramon V. Tiu; Mikkael A. Sekeres; Jaroslaw P. Maciejewski
BLOOD, 116(21), 1381-1381, 2010年11月

Cytogenetic Predictors of Response to Lenalidomide In Myeloid Malignancies without Del(5q)
Yuka Sugimoto; Mikkael A. Sekeres; Hideki Makishima; Christine L. O'Keefe; Kathryn Guinta; Manuel Afable; Kathy Rocha McGraw; Alan F. List; Jaroslaw Maciejewski
BLOOD, 116(21), 1637-1637, 2010年11月

CBL, CBLB, TET2, ASXL1, and IDH1/2 Mutations as Well as Additional Chromosomal Aberrations Constitute Molecular Events Contributing to Malignant Progression In Advanced Philadelphia Chromosome-Positive Disorders
Hideki Makishima; Anna Jankowska; Michael A. McDevitt; Simon Dujardin; Heather Cazzolli; Bartlomiej Przychodzen; Courtney Prince; John Nicoll; Siddaiah Harish; Mohammed Shaik; Eric Hsi; Anjali Advani; Ronald Paquette; Jaroslaw P. Maciejewski
BLOOD, 116(21), 1390-1390, 2010年11月

Sensitivity of a Homozygous c-Cbl Mutant AML Cell Line (JPM11) to Tyrosine Kinase Inhibitors, Implications for Potential Targeted Molecular Therapy.
Hideki Makishima; Yuka Sugimoto; Hadrian Szpurka; Courtney Prince; Michael Clemente; Hideki Muramatsu; Andrew E. Schade; Jaroslaw P. Maciejewski
BLOOD, 114(22), 1023-1023, 2009年11月

Cbl and TET2 Mutations Are Present in Refractory Ph plus Disorders Including Accelerated and Blast Crisis CML and ALL
Hideki Makishima; Anna M. Jankowska; Heather Cazzolli; Bartlomiej P. Przychodzen; Courtney Prince; Siddaiah Harish; Heesun J. Rogers; Eric D. Hsi; Michael A. McDevitt; Anjali Advani; Ronald Paquette; Jaroslaw P. Maciejewski
BLOOD, 114(22), 855-855, 2009年11月

TET2 Mutations Are Frequent in RARS-T
Hadrian Szpurka; Anna M. Jankowska; Hideki Makishima; Nelli Bejanyan; Eric D. Hsi; Mikkael A. Sekeres; Jaroslaw P. Maciejewski
BLOOD, 114(22), 1459-1459, 2009年11月

Molecular Lesions Associated with Loss of Heterozygosity Identified in CMML
Anna M. Jankowska; Hideki Makishima; Rebecca D. Ganetzky; Monika Jasek; Heather Cazzolli; Courtney Prince; Manuel Afable; Christine O'Keefe; Ramon V. Tiu; Heesun J. Rogers; Eric D. Hsi; Mikkael A. Sekeres; Michael A. McDevitt; Jaroslaw P. Maciejewski
BLOOD, 114(22), 173-173, 2009年11月

TET2 gene harbors mutations associated with myeloid malignancies
A. M. Jankowska; H. Szpurka; R. V. Tiu; H. Makishima; M. Afable; J. Huh; C. O'Keefe; R. Ganetzky; M. A. McDevitt; J. P. Maciejewski
LEUKEMIA RESEARCH, 33, S84-S84, 2009年05月

Mutations of E3 ubiquitin ligase Cbl family members constitute a novel common pathogenic lesion in myelodysplastic syndromes
H. Makishima
LEUKEMIA RESEARCH, 33, S58-S58, 2009年05月

Frequent Detection of C-Cbl Homozygous Mutation in Secondary Myelogeneous Leukemia Transformed from MDS/MPD with Chromosome 11q Uniparental Disomy
Hideki Makishima; Andrew J. Dunbar; Anna M. Jankowska; Lukasz P. Gondek; Eric D. Hsi; Michael A. McDevitt; Alan F. List; Jaroslaw P. Maciejewski
BLOOD, 112(11), 315-315, 2008年11月

SNP-a Karyotyping Provides a Clonal Molecular Marker and Is Associated with a High Incidence of Segmental Uniparental Disomy in Patients with CMML
Michael McDevitt; Andrew Jeffrey Dunbar; Christine O'Keefe; Hideki Makishima; Ramon V. Tiu; Lukasz Gondek; Judith E. Karp; Xiao-Fei Wang; Mark J. Levis; Jaroslaw Maciejewski
BLOOD, 112(11), 1252-1253, 2008年11月

FISH and SNP-Array Karyotyping Improve the Detection of Recurrent Chromosomal Defects Including Del(5q), Monosomy 7, Del(7q), Trisomy 8, and Del(20q) in Myelodysplastic Syndromes
Hideki Makishima; Manjot Rataul; Lukasz P. Gondek; Jungwon Huh; James R. Cook; Karl S. Theil; Mikkael A. Sekeres; Elizabeth Kuczkowski; Jaroslaw P. Maciejewski
BLOOD, 112(11), 527-527, 2008年11月

抗HLAクラスI抗体の方法別検出感度と血小板輸血患者における方法別抗体検出率 : AHG-LCT, LIFT, PIFT, M-MPHAおよび FlowPRA の比較
斉藤 敏; 太田 正穂; 勝山 善彦; 牧島 秀樹; 玉井 豊広; 高柳 カヨ子; 浅村 英樹; 福島 弘文
日本輸血学会雑誌, 50(6), 753-760, 2004年12月20日

Expression levels of CXCR1 and CCR5 on natural killer (NK) cells in aggressive NK cell leukemia and chronic NK cell lymphocytosis.
H Makishima; F Ishida; T Ito; S Shimodaira; K Kiyosawa
BLOOD, 102(11), 604A-604A, 2003年11月

Identification of novel molecular markers in T cell type lymphoproliferative disease of granular lymphocytes by microarray analysis with purified T cell populations.
H Makishima; F Ishida; K Kitano; K Kiyosawa; K Omine; H Mano
BLOOD, 98(11), 162B-162B, 2001年11月

蛋白漏出性胃腸症と汎血球減少症を合併した脾臓原発組織球性肉腫の一例
牧島 秀樹; 北野 喜良
日本リンパ網内系学会会誌 = The journal of the Japanese Society of Lymphoreticular Tissue, 40(4), 205-210, 2001年01月31日

Skewed T cell receptor repertoires with oligoclonal profiles in patients with CD8-positive T cell lymphoproliferative disease of granular lymphocytes.
H Makishima; F Ishida; T Ito; M Ota; Y Katsuyama; M Ueno; S Shimodaira; K Kitano; K Kiyosawa
BLOOD, 96(11), 127A-127A, 2000年11月

病理学（腫瘍）
京都大学大学院医学研究科

医学概論（腫瘍学）
京都大学大学院医学研究科

ヨーロッパ血液学会

アメリカ血液学会

アメリカ内科学会

日本造血細胞移植学会

日本臨床腫瘍学会

日本癌学会

日本血液学会

日本内科学会

先端ゲノミクスを駆使したがんの初期発生とクローン進化に関わる分子基盤の解明
科学研究費助成事業, 日本学術振興会, 基盤研究(S)
京都大学
2019年06月26日 - 2024年03月31日

骨髄不全症候群における胚細胞変異および体細胞変異の解明に基づく新規治療開発
科学研究費助成事業, 日本学術振興会, 基盤研究(A)
京都大学
2019年04月01日 - 2024年03月31日

骨髄不全症候群における、網羅的シーケンス解析による分子病態の解明
科学研究費助成事業, 日本学術振興会, 基盤研究(B)
京都大学
2016年04月01日 - 2019年03月31日

骨髄系腫瘍における網羅的エクソーム・ゲノム解析
科学研究費助成事業, 日本学術振興会, 研究活動スタート支援
京都大学
2015年08月28日 - 2016年03月31日

大規模シーケンスとコンピューティングによるがんの進化と多様性の解明
科学研究費助成事業, 日本学術振興会, 新学術領域研究(研究領域提案型)
京都大学
2015年06月29日 - 2020年03月31日

骨髄異形成症候群(MDS)の分子基盤の解明
科学研究費助成事業, 日本学術振興会, 基盤研究(S)
京都大学
2014年05月 - 2019年03月

わが国におけるセリアック病の頻度と合併症に関する検索
科学研究費助成事業, 日本学術振興会, 若手研究(B)
信州大学
2006年 - 2008年

ヒトにおける骨髄腫瘍の発症又は発症リスクを検査する指標の取得方法、ヒトにおけるDDX41遺伝子の体細胞変異の存在又は将来的な発生を予測する指標の取得方法、並びに、これらの検査又は予測のためのキット, 特開2017-104035, 特願2015-239547, 特許権
小川 誠司; 牧島 秀樹; 吉田 健一