田中 直樹 (タナカ ナオキ)
学術研究院（医学系）
医学部 医学科
教授
研究者情報
研究キーワード
- 非アルコール性脂肪性肝疾患・脂肪肝炎, NASH, 核内受容体、PPAR, メタボリックシンドローム, 脂肪細胞, 肝臓病学, 病態栄養, 肥満, 毒性学
研究分野
電話番号
- 0263-37-2354
経歴
研究活動情報
受賞
- 2020年
第23回日本病態栄養学会年次学術集会 若手研究会長賞
日本
第23回日本病態栄養学会年次学術集会 若手研究会長賞 - 2015年
米国国立衛生研究所, The Fellows Award for Research Excellence in NIH
The Fellows Award for Research Excellence in NIH - 2014年
米国国立衛生研究所, The Fellows Award for Research Excellence in NIH
The Fellows Award for Research Excellence in NIH - 2013年
米国国立衛生研究所, The Fellows Award for Research Excellence in NIH
The Fellows Award for Research Excellence in NIH - 2010年
第23回日本消化器病学会奨励賞
日本
第23回日本消化器病学会奨励賞 - 2009年
信州大学医学部松医会賞基礎分野
日本
信州大学医学部松医会賞基礎分野 - 2008年
日本肝臓学会第7回Schering-Plough Award基礎分野優秀賞
日本
日本肝臓学会第7回Schering-Plough Award基礎分野優秀賞 - 2007年
ウイルス肝炎研究財団 研究助成
ウイルス肝炎研究財団 研究助成
論文
- Prognostic Significance of Bile Duct Loss in Early-Stage Primary Biliary Cholangitis: A Long-Term Observational Study.
Taiki Okumura; Takefumi Kimura; Takanobu Iwadare; Shun-Ichi Wakabayashi; Hiroyuki Kobayashi; Yuki Yamashita; Satoru Joshita; Michiharu Komatsu; Naoki Tanaka; Akihiro Matsumoto; Tomoyuki Nakajima; Mai Iwaya; Masahiro Umemura; Kazuhito Kawata; Kenichi Harada; Takeji Umemura
Hepatology research : the official journal of the Japan Society of Hepatology, 2025年08月, 査読有り
- Multi-omics analysis of diabetic cardiomyopathy pathogenesis using a type 2 diabetic Zucker diabetic fatty rat model.
Kazuhiro Tanabe; Qianqian Zheng; Xuguang Zhang; Naoki Tanaka; Chihiro Hayashi; Asaka Yokota; Rina Otsuka; Tomoko Katahira; Motoyuki Kohjima; Makoto Nakamuta
Scientific reports, 15(1), 22797-22797, 2025年07月, 査読有り - Thrombospondin 2 as a Predictive Biomarker for HCC in Hepatitis C Patients: A Longitudinal Study Following DAA Therapy.
Takanobu Iwadare; Takefumi Kimura; Ayumi Sugiura; Taiki Okumura; Shun-Ichi Wakabayashi; Hiroyuki Kobayashi; Yuki Yamashita; Tomoo Yamazaki; Satoru Joshita; Naoki Tanaka; Takeji Umemura
Journal of viral hepatitis, 32(4), e14025, 2025年04月, 査読有り - AI-Based Platelet-Independent Noninvasive Test for Liver Fibrosis in MASLD Patients.
Shun-Ichi Wakabayashi; Takefumi Kimura; Nobuharu Tamaki; Takanobu Iwadare; Taiki Okumura; Hiroyuki Kobayashi; Yuki Yamashita; Naoki Tanaka; Masayuki Kurosaki; Takeji Umemura
JGH open : an open access journal of gastroenterology and hepatology, 9(4), e70150, 2025年04月, 査読有り - Dietary Polyunsaturated Fatty Acid Deficiency Impairs Renal Lipid Metabolism and Adaptive Response to Proteinuria in Murine Renal Tubules.
Yaping Wang; Pan Diao; Daiki Aomura; Takayuki Nimura; Makoto Harada; Fangping Jia; Takero Nakajima; Naoki Tanaka; Yuji Kamijo
Nutrients, 17(6), 2025年03月, 査読有り - Colorectal Cancer Incidence in Steatotic Liver Disease (MASLD, MetALD, and ALD).
Takefumi Kimura; Nobuharu Tamaki; Shun-Ichi Wakabayashi; Naoki Tanaka; Takeji Umemura; Namiki Izumi; Rohit Loomba; Masayuki Kurosaki
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2025年01月, 査読有り - Potential of serum sulfatide levels as a marker for classification and disease activity in lupus nephritis.
Kosuke Yamaka; Daiki Aomura; Makoto Harada; Takero Nakajima; Takayuki Nimura; Koji Hashimoto; Naoki Tanaka; Yuji Kamijo
Frontiers in immunology, 16, 1571147-1571147, 2025年, 査読有り - Comparison of Free Flavonoids and the Polyphenol Content in the Bran of a Newly Developed Sorghum Variety and Two Commercially Available Sorghum Varieties.
Mariely Cristine Dos Santos; Naoki Tanaka; Shigemitsu Kasuga; Kazuhiro Tanabe; Chihiro Hayashi; Masahiro Mizuno; Yoshihiko Amano
Metabolites, 14(11), 2024年11月, 査読有り - Circulating thrombospondin 2 as a predictor of hepatocellular carcinoma in hepatitis B patients undergoing nucleos(t)ide analog therapy.
Taiki Okumura; Takefumi Kimura; Yuki Ichikawa; Takanobu Iwadare; Shun-Ichi Wakabayashi; Hiroyuki Kobayashi; Yuki Yamashita; Takuro Uchida; Sai P Pydi; Naoki Tanaka; Takeji Umemura
Scientific reports, 14(1), 25584-25584, 2024年10月, 査読有り - Serum autotaxin is a prognostic indicator of liver-related events in patients with non-alcoholic fatty liver disease.
Takanobu Iwadare; Takefumi Kimura; Taiki Okumura; Shun-Ichi Wakabayashi; Taro Nakajima; Shohei Kondo; Hiroyuki Kobayashi; Yuki Yamashita; Ayumi Sugiura; Naoyuki Fujimori; Tomoo Yamazaki; Hideo Kunimoto; Satoshi Shimamoto; Koji Igarashi; Satoru Joshita; Naoki Tanaka; Takeji Umemura
Communications medicine, 4(1), 73-73, 2024年04月, 査読有り - Predictive Insights Into Exocrine Pancreatic Insufficiency in Chronic Pancreatitis and Autoimmune Pancreatitis: A Decision Tree Approach.
Tomoyuki Tanaka; Takefumi Kimura; Shun-Ichi Wakabayashi; Takuma Okamura; Shohei Shigeto; Naoki Tanaka; Shohei Kondo; Ichitaro Horiuchi; Yasuhiro Kuraishi; Akira Nakamura; Norihiro Ashihara; Keita Kanai; Tadanobu Nagaya; Takayuki Watanabe; Takeji Umemura
Pancreas, 53(3), e227-e232, 2024年03月, 査読有り - Thrombospondin 2 is a key determinant of fibrogenesis in non-alcoholic fatty liver disease.
Takefumi Kimura; Takanobu Iwadare; Shun-Ichi Wakabayashi; Seema Kuldeep; Tomoyuki Nakajima; Tomoo Yamazaki; Daiki Aomura; Hamim Zafar; Mai Iwaya; Satoru Joshita; Takeshi Uehara; Sai P Pydi; Naoki Tanaka; Takeji Umemura
Liver international : official journal of the International Association for the Study of the Liver, 44(2), 483-496, 2024年02月, 査読有り - Investigation of Clinical Features and Association between Vascular Endothelial Injury Markers and Cytomegalovirus Infection Associated with Thrombotic Microangiopathy in Patients with Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis: Case-Based Research.
Takayuki Nimura; Daiki Aomura; Makoto Harada; Akinori Yamaguchi; Kosuke Yamaka; Takero Nakajima; Naoki Tanaka; Takashi Ehara; Koji Hashimoto; Yuji Kamijo
International journal of molecular sciences, 25(2), 2024年01月, 査読有り - Long-Term pemafibrate treatment exhibits limited impact on body fat mass in patients with hypertriglyceridemia accompanying NAFLD.
Takanobu Iwadare; Takefumi Kimura; Hideo Kunimoto; Taiki Okumura; Shun-Ichi Wakabayashi; Hiroyuki Kobayashi; Yuki Yamashita; Ayumi Sugiura; Naoki Tanaka; Takeji Umemura
Frontiers in endocrinology, 15, 1329294-1329294, 2024年, 査読有り - An orally deliverable ornithine-based self-assembling polymer nanomedicine ameliorates hyperammonemia in acetaminophen-induced acute liver injury.
Yuanyuan Ding; Yuta Koda; Babita Shashni; Naoki Takeda; Xuguang Zhang; Naoki Tanaka; Yuji Nishikawa; Yukio Nagasaki
Acta biomaterialia, 168, 515-528, 2023年09月, 査読有り - Establishment of Novel Mouse Model of Dietary NASH Rapidly Progressing into Liver Cirrhosis and Tumors.
Qianqian Zheng; Masaya Kawaguchi; Hayato Mikami; Pan Diao; Xuguang Zhang; Zhe Zhang; Takero Nakajima; Takanobu Iwadare; Takefumi Kimura; Jun Nakayama; Naoki Tanaka
Cancers, 15(14), 2023年07月, 査読有り
最終著者, 責任著者 - 多機能性分子・硫酸化糖脂質の機能と制御
中嶌岳郎, 田中直樹
信州医学雑誌, 71(3), 137-147, 2023年06月, 査読有り - Citrin Deficiency: Clinical and Nutritional Features.
Michiharu Komatsu; Naoki Tanaka; Takefumi Kimura; Masahide Yazaki
Nutrients, 15(10), 2023年05月, 査読有り
責任著者 - Resmetirom Ameliorates NASH-Model Mice by Suppressing STAT3 and NF-κB Signaling Pathways in an RGS5-Dependent Manner.
Xiaojing Wang; Liangjing Wang; Lin Geng; Naoki Tanaka; Bin Ye
International journal of molecular sciences, 24(6), 2023年03月, 査読有り
責任著者 - Dietary Fat Composition Affects Hepatic Angiogenesis and Lymphangiogenesis in Hepatitis C Virus Core Gene Transgenic Mice.
Pan Diao; Yaping Wang; Fangping Jia; Xiaojing Wang; Xiao Hu; Takefumi Kimura; Yoshiko Sato; Kyoji Moriya; Kazuhiko Koike; Jun Nakayama; Naoki Tanaka
Liver cancer, 12(1), 57-71, 2023年02月, 査読有り
最終著者, 責任著者 - Development of the Rabbit NASH Model Resembling Human NASH and Atherosclerosis.
Momoko Hayashi; Yoshibumi Kuwabara; Kuniji Ito; Yoshiaki Hojo; Fumiaki Arai; Kazuki Kamijima; Masakazu Takeiri; Xiaojing Wang; Pan Diao; Jun Nakayama; Naoki Tanaka
Biomedicines, 11(2), 2023年01月, 査読有り
最終著者, 責任著者 - PPARα activator irbesartan suppresses the proliferation of endometrial carcinoma cells via SREBP1 and ARID1A.
Y U Lu; Tsutomu Miyamoto; Hodaka Takeuchi; Fumi Tsunoda; Naoki Tanaka; Tanri Shiozawa
Oncology research, 31(3), 239-253, 2023年, 査読有り - Serum sulfatide level is associated with severe systemic vasculitis with kidney involvement.
Daiki Aomura; Makoto Harada; Takero Nakajima; Takayuki Nimura; Kosuke Yamaka; Yosuke Yamada; Koji Hashimoto; Naoki Tanaka; Yuji Kamijo
Frontiers in immunology, 14, 1271741-1271741, 2023年, 査読有り - Circulating thrombospondin 2 levels reflect fibrosis severity and disease activity in HCV-infected patients.
Takanobu Iwadare; Takefumi Kimura; Naoki Tanaka; Tomoo Yamazaki; Shun-Ichi Wakabayashi; Taiki Okumura; Hiroyuki Kobayashi; Yuki Yamashita; Sai P Pydi; Tomoyuki Nakajima; Mai Iwaya; Ayumi Sugiura; Satoru Joshita; Takeshi Uehara; Takeji Umemura
Scientific reports, 12(1), 18900-18900, 2022年11月, 査読有り - Higher Responsiveness for Women, High Transaminase Levels, and Fat Percentage to Pemafibrate Treatment for NAFLD.
Takanobu Iwadare; Takefumi Kimura; Hideo Kunimoto; Naoki Tanaka; Shun-Ichi Wakabayashi; Tomoo Yamazaki; Taiki Okumura; Hiroyuki Kobayashi; Yuki Yamashita; Ayumi Sugiura; Satoru Joshita; Takeji Umemura
Biomedicines, 10(11), 2022年11月, 査読有り - Clinically Relevant Dose of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα), Lowers Serum Triglyceride Levels by Targeting Hepatic PPARα in Mice.
Zhe Zhang; Pan Diao; Xuguang Zhang; Takero Nakajima; Takefumi Kimura; Naoki Tanaka
Biomedicines, 10(7), 2022年07月, 査読有り
最終著者, 責任著者 - Pemafibrate for primary biliary cholangitis with dyslipidemia: A proposal of a new treatment from Japan.
Naoki Tanaka; Akira Honda
Hepatology research : the official journal of the Japan Society of Hepatology, 52(6), 495-496, 2022年06月, 査読有り
筆頭著者, 責任著者 - Managing bleeding risk after cold snare polypectomy in patients receiving direct-acting oral anticoagulants.
Atsushi Morita; Ichitaro Horiuchi; Naoki Tanaka; Hidetoshi Takada; David Y Graham; Akira Horiuchi
Gastrointestinal endoscopy, 95(5), 969-974, 2022年05月, 査読有り - 2-Step PLT16-AST44 method: Simplified liver fibrosis detection system in patients with non-alcoholic fatty liver disease
Fujimori, Naoyuki; Kimura, Takefumi; Tanaka, Naoki; Yamazaki, Tomoo; Okumura, Taiki; Kobayashi, Hiroyuki; Wakabayashi, Shun-Ichi; Yamashita, Yuki; Sugiura, Ayumi; Pham, Jonathan; Pydi, Sai P.; Sano, Kenji; Joshita, Satoru; Umemura, Takeji
HEPATOLOGY RESEARCH, 52(4), 352-363, 2022年04月, 査読有り - Serum Sulfatide Levels as a Biomarker of Active Glomerular Lesion in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Single Center Pilot Study
Harada, Makoto; Nakajima, Takero; Yamada, Yosuke; Aomura, Daiki; Yamaguchi, Akinori; Sonoda, Kosuke; Tanaka, Naoki; Hashimoto, Koji; Kamijo, Yuji
JOURNAL OF CLINICAL MEDICINE, 11(3), 762, 2022年02月, 査読有り - Short-term intensive gastrointestinal endoscopy training program.
Atsushi Morita; Takahiro Kudo; Akira Horiuchi; Masashi Kajiyama; Naoki Tanaka; Hidetoshi Takada
Pediatrics international : official journal of the Japan Pediatric Society, 64(1), e14721, 2022年01月, 査読有り - Acidic Activated Charcoal Prevents Obesity and Insulin Resistance in High-Fat Diet-Fed Mice.
Xuguang Zhang; Pan Diao; Hiroaki Yokoyama; Yoshiki Inoue; Kazuhiro Tanabe; Xiaojing Wang; Chihiro Hayashi; Tomoki Yokoyama; Zhe Zhang; Xiao Hu; Takero Nakajima; Takefumi Kimura; Jun Nakayama; Makoto Nakamuta; Naoki Tanaka
Frontiers in nutrition, 9, 852767-852767, 2022年, 査読有り
最終著者, 責任著者 - Mechanisms of Steatosis-Derived Hepatocarcinogenesis: Lessons from HCV Core Gene Transgenic Mice
Diao, Pan; Jia, Fangping; Wang, Xiaojing; Hu, Xiao; Kimura, Takefumi; Nakajima, Takero; Aoyama, Toshifumi; Moriya, Kyoji; Koike, Kazuhiko; Tanaka, Naoki
ENGINEERING, 7(12), 1797-1805, 2021年12月, 査読有り
最終著者, 責任著者 - Mucosal defect size predicts the adequacy of resection of <= 10 mm nonpedunculated colorectal polyps using a new cold snare polypectomy technique
Kudo, Takahiro; Horiuchi, Akira; Kyodo, Reiko; Tokita, Kazuhide; Tanaka, Naoki; Horiuchi, Ichitaro; Sano, Kenji
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 33, E484-E489, 2021年12月, 査読有り - Impact of Dietary Fat on the Progression of Liver Fibrosis: Lessons from Animal and Cell Studies
Jia, Fangping; Hu, Xiao; Kimura, Takefumi; Tanaka, Naoki
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(19), 10303, 2021年10月, 査読有り
最終著者, 責任著者 - Pemafibrate, a novel selective PPARα modulator, attenuates tamoxifen-induced fatty liver disease.
Naoki Tanaka; Kazutaka Mukaiyama; Akio Morikawa; Satoshi Kawakami; Yasuyuki Ichise; Takefumi Kimura; Akira Horiuchi
Clinical journal of gastroenterology, 14(3), 846-851, 2021年06月, 査読有り
筆頭著者, 責任著者 - Linked colour imaging versus white-light colonoscopy for the detection of flat colorectal lesions: A randomized controlled trial
Kudo, Takahiro; Horiuchi, Akira; Kyodo, Reiko; Horiuchi, Ichitaro; Arai, Nobuyasu; Kajiyama, Masashi; Tanaka, Naoki
COLORECTAL DISEASE, 23(6), 1414-1420, 2021年06月, 査読有り
最終著者 - Pemafibrate Protects against Fatty Acid-Induced Nephropathy by Maintaining Renal Fatty Acid Metabolism
Aomura, Daiki; Harada, Makoto; Yamada, Yosuke; Nakajima, Takero; Hashimoto, Koji; Tanaka, Naoki; Kamijo, Yuji
METABOLITES, 11(6), 372, 2021年06月, 査読有り - Risk of Gastrointestinal Endoscopic Procedure-Related Bleeding in Patients With or Without Continued Antithrombotic Therapy.
Kiyoaki Yabe; Akira Horiuchi; Takahiro Kudo; Ichitaro Horiuchi; Yasuyuki Ichise; Masashi Kajiyama; Naoki Tanaka
Digestive diseases and sciences, 66(5), 1548-1555, 2021年05月, 査読有り - Serum thrombospondin 2 is a novel predictor for the severity in the patients with NAFLD
Kimura, Takefumi; Tanaka, Naoki; Fujimori, Naoyuki; Yamazaki, Tomoo; Katsuyama, Takahito; Iwashita, Yuichi; Pham, Jonathan; Joshita, Satoru; Pydi, Sai P.; Umemura, Takeji
LIVER INTERNATIONAL, 41(3), 505-514, 2021年03月, 査読有り - Role of G Protein-Coupled Receptors in Hepatic Stellate Cells and Approaches to Anti-Fibrotic Treatment of Non-Alcoholic Fatty Liver Disease
Kimura, Takefumi; Singh, Simran; Tanaka, Naoki; Umemura, Takeji
FRONTIERS IN ENDOCRINOLOGY, 12, 773432-773432, 2021年, 査読有り
責任著者 - A saturated fatty acid-rich diet enhances hepatic lipogenesis and tumorigenesis in HCV core gene transgenic mice
Diao, Pan; Wang, Xiaojing; Jia, Fangping; Kimura, Takefumi; Hu, Xiao; Shirotori, Saki; Nakamura, Ibuki; Sato, Yoshiko; Nakayama, Jun; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Aoyama, Toshifumi; Tanaka, Naoki
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 85, 2020年11月, 査読有り
最終著者, 責任著者 - Invasive liver abscess syndrome accompanied by spondylodiscitis: a case report and review of the literature
Wakabayashi SI, Kimura T, Tanaka N, Pham J, Tanaka T, Higuchi S, Kobayashi J, Umemura T, Iijima A.
Clin J Gastroenterol, 13(5), 927-934, 2020年10月, 査読有り - Metabolic Functions of G Protein-Coupled Receptors in Hepatocytes-Potential Applications for Diabetes and NAFLD
Kimura, Takefumi; Pydi, Sai P.; Pham, Jonathan; Tanaka, Naoki
BIOMOLECULES, 10(10), 2020年10月, 査読有り
最終著者 - Non-alcoholic fatty liver disease later diagnosed as myotonic dystrophy
Tanaka N, Kimura T, Fujimori N, Ichise Y, Sano K, Horiuchi A.
World J Hepatol. 2020 Sep 27;12(9):685-692. doi: 10.4254/wjh.v12.i9.685., 12(9), 685-692, 2020年09月, 査読有り
筆頭著者, 責任著者 - Acute liver failure with severe steatosis induced by mushroom
Wakabayashi, Shun-ichi; Kimura, Takefumi; Tanaka, Naoki
LIVER INTERNATIONAL, 40(9), 2291-2292, 2020年09月, 査読有り
最終著者 - Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice
Jia, Fangping; Diao, Pan; Wang, Xiaojing; Hu, Xiao; Kimura, Takefumi; Nakamuta, Makoto; Nakamura, Ibuki; Shirotori, Saki; Sato, Yoshiko; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Nakayama, Jun; Aoyama, Toshifumi; Tanaka, Naoki
LIVER CANCER, 9(5), 529-548, 2020年09月, 査読有り
最終著者, 責任著者 - Polyunsaturated fatty acid deficiency affects sulfatides and other sulfated glycans in lysosomes through autophagy-mediated degradation
Wang, Yaping; Nakajima, Takero; Diao, Pan; Yamada, Yosuke; Nakamura, Kozo; Nakayama, Jun; Tanaka, Naoki; Aoyama, Toshifumi; Kamijo, Yuji
FASEB JOURNAL, 34(7), 9594-9614, 2020年07月, 査読有り - Congestive hepatopathy and acute pancreatitis as severe complications of mixed connective tissue disease
Kurihara S, Kimura T, Tanaka N, Yanagisawa T, Kobayashi H, Kanai K, Umemura T, Kobayashi M, Mori H, Wada S.
Clin J Gastroenterol, 13(3), 434-442, 2020年06月, 査読有り - PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice
Wang, Yaping; Nakajima, Takero; Gonzalez, Frank J.; Tanaka, Naoki
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(6), -, 2020年03月, 査読有り
最終著者, 責任著者 - Long-term luseogliflozin therapy improves histological activity of non-alcoholic steatohepatitis accompanied by type 2 diabetes mellitus
Fujimori N, Tanaka N, Kimura T, Sano K, Horiuchi A, Kato N, Takahashi Y, Kuribayashi N, Sugiura A, Yamazaki T, Joshita S, Umemura T, Matsumoto A, Tanaka E.
Clin J Gastroenterol, 13(1), 83-89, 2020年02月, 査読有り
責任著者 - A trans-fatty acid-rich diet promotes liver tumorigenesis in HCV core gene transgenic mice
Hu, Xiao; Wang, Xiaojing; Jia, Fangping; Tanaka, Naoki; Kimura, Takefumi; Nakajima, Takero; Sato, Yoshiko; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Nakayama, Jun; Aoyama, Toshifumi
CARCINOGENESIS, 41(2), 159-170, 2020年02月, 査読有り
責任著者 - Cold snare polypectomy: Indications, devices, techniques, outcomes and future
Horiuchi, Akira; Ikuse, Tamaki; Tanaka, Naoki
DIGESTIVE ENDOSCOPY, 31(4), 372-377, 2019年07月, 査読有り
最終著者 - What will happen in patients with advanced nonalcoholic fatty liver disease?
Takefumi Kimura; Naoki Tanaka; Eiji Tanaka
Hepatobiliary surgery and nutrition, 8(3), 283-285, 2019年06月 - A high-cholesterol diet promotes steatohepatitis and liver tumorigenesis in HCV core gene transgenic mice
Wang, Xiaojing; Tanaka, Naoki; Hu, Xiao; Kimura, Takefumi; Lu, Yu; Jia, Fangping; Sato, Yoshiko; Nakayama, Jun; Moriya, Kyoji; Koike, Kazuhiko; Aoyama, Toshifumi
ARCHIVES OF TOXICOLOGY, 93(6), 1713-1725, 2019年06月, 査読有り
責任著者 - Lipidomics reveal aryl hydrocarbon receptor (Ahr)-regulated lipid metabolic pathway in alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis.
Bao-Long Wang; Chang-Wen Zhang; Liang Wang; Kun-Long Tang; Naoki Tanaka; Frank J Gonzalez; Yong Xu; Zhong-Ze Fang
Xenobiotica; the fate of foreign compounds in biological systems, 49(5), 591-601, 2019年05月 - Safety and Effectiveness of Nurse-Administered Propofol Sedation in Outpatients Undergoing Gastrointestinal Endoscopy
Sato, Masamichi; Horiuchi, Akira; Tamaki, Michio; Ichise, Yasuyuki; Kajiyama, Masashi; Yamamoto, Yuta; Tanaka, Naoki
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 17(6), 1098-+, 2019年05月, 査読有り
最終著者 - Red plasma and ascites under ultraviolet A
Wakabayashi, Shun-ichi; Kimura, Takefumi; Tanaka, Naoki; Komatsu, Michiharu; Tanaka, Eiji
LANCET GASTROENTEROLOGY & HEPATOLOGY, 4(4), 324-324, 2019年04月, 査読有り - Peroxisome proliferator-activated receptor attenuates high-cholesterol diet-induced toxicity and pro-thrombotic effects in mice
Lu, Yu; Harada, Makoto; Kamijo, Yuji; Nakajima, Takero; Tanaka, Naoki; Sugiyama, Eiko; Kyogashima, Mamoru; Gonzalez, Frank J.; Aoyama, Toshifumi
ARCHIVES OF TOXICOLOGY, 93(1), 149-161, 2019年01月, 査読有り, 招待無し - Gastric Emptying of Elemental Liquid Diets Versus Semisolid Diets in Bedridden Gastrostomy-fed Patients
Horiuchi, Akira; Sakai, Ryosei; Tamaki, Michio; Kajiyama, Masashi; Tanaka, Naoki; Morikawa, Akio
JOURNAL OF CLINICAL GASTROENTEROLOGY, 53(5), 373-378, 2019年, 査読有り - Current status, problems, and perspectives of non-alcoholic fatty liver disease research
Tanaka, Naoki; Kimura, Takefumi; Fujimori, Naoyuki; Nagaya, Tadanobu; Komatsu, Michiharu; Tanaka, Eiji
WORLD JOURNAL OF GASTROENTEROLOGY, 25(2), 163-177, 2019年, 査読有り, 招待無し
筆頭著者, 責任著者 - Miglitol attenuates non-alcoholic steatohepatitis in diabetic patients
Komatsu, Michiharu; Tanaka, Naoki; Kimura, Takefumi; Fujimori, Naoyuki; Sano, Kenji; Horiuchi, Akira; Sugiura, Ayumi; Yamazaki, Tomoo; Shibata, Soichiro; Joshita, Satoru; Umemura, Takeji; Matsumoto, Akihiro; Tanaka, Eiji
HEPATOLOGY RESEARCH, 48(13), 1092-1098, 2018年12月, 査読有り, 招待無し
責任著者 - Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development.
Takahashi S; Tanaka N; Fukami T; Xie C; Yagai T; Kim D; Velenosi TJ; Yan T; Krausz KW; Levi M; Gonzalez FJ
Hepatol Commun, 2(12), 1567-1582, 2018年10月, 査読有り, 招待無し
筆頭著者 - Emergence of anti-mitochondrial M2 antibody in patient with angioimmunoblastic T-cell lymphoma.
Wakabayashi SI; Kimura T; Tanaka N; Joshita S; Kawata K; Umemura T; Hiroshima Y; Mori H; Kobayashi H; Wada S; Tanaka E
Clin J Gastroenterol, 11(4), 302-308, 2018年08月, 査読有り, 招待無し - Salmonella Enteritidis cholecystitis with chronic granulomatous disease.
Yamashita Y; Kimura T; Tanaka N; Yazaki M; Itagaki T; Joshita S; Umemura T; Matsumoto A; Mori H; Wada S; Tanaka E
IDCases, 12, 12:49-52, 2018年05月, 査読有り, 招待無し - Mild drinking habit is a risk factor for hepatocarcinogenesis in non-alcoholic fatty liver disease with advanced fbrosis
Takefumi Kimura; Naoki Tanaka; Naoyuki Fujimori; Ayumi Sugiura; Tomoo Yamazaki; Satoru Joshita; Michiharu Komatsu; Takeji Umemura; Akihiro Matsumoto; Eiji Tanaka
World Journal of Gastroenterology, 24(13), 1440-1450, 2018年04月, 査読有り, 招待無し
責任著者 - Serum autotaxin levels are correlated with hepatic fibrosis and ballooning in patients with non-alcoholic fatty liver disease
Naoyuki Fujimori; Takeji Umemura; Takefumi Kimura; Naoki Tanaka; Ayumi Sugiura; Tomoo Yamazaki; Satoru Joshita; Michiharu Komatsu; Yoko Usami; Kenji Sano; Koji Igarashi; Akihiro Matsumoto; Eiji Tanaka
World Journal of Gastroenterology, 24(11), 1239-1249, 2018年03月, 査読有り, 招待無し - Hepatic Angiosarcoma with Kasabach-Merritt Phenomenon: A Case Report and Review of the Literature
Fujii, Fumika; Kimura, Takefumi; Tanaka, Naoki; Kubota, Daisuke; Sugiura, Ayumi; Umemura, Takeji; Wada, Shuichi; Tanaka, Eiji
ANNALS OF HEPATOLOGY, 17(4), 655-660, 2018年, 査読有り, 招待無し - Delayed Bleeding Following Cold Snare Polypectomy for Small Colorectal Polyps in Patients Taking Antithrombotic Agents
Toshiyuki Makino; Akira Horiuchi; Masashi Kajiyama; Naoki Tanaka; Kenji Sano; Iruru Maetani
Journal of Clinical Gastroenterology, 52(6), 502-507, 2018年, 査読有り, 招待無し - Growth arrest and DNA damage-inducible 45 alpha protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet
Naoki Tanaka; Shogo Takahashi; Xiao Hu; Yu Lu; Naoyuki Fujimori; Srujana Golla; Zhong-Ze Fang; Toshifumi Aoyama; Kristopher W. Krausz; Frank J. Gonzalez
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1863(12), 3170-3182, 2017年12月, 査読有り, 招待無し
筆頭著者
- Targeting nuclear receptors for the treatment of fatty liver disease
Naoki Tanaka; Toshifumi Aoyama; Shioko Kimura; Frank J. Gonzalez
PHARMACOLOGY & THERAPEUTICS, 179, 142-157, 2017年11月, 査読有り, 招待無し
筆頭著者, 責任著者 - Cimetidine/lactulose therapy ameliorates erythropoietic protoporphyria-related liver injury
Fujimori N; Komatsu M; Tanaka N; Iwaya M; Nakano H; Sugiura A; Yamazaki T; Shibata S; Iwaya Y; Muraki T; Ichikawa Y; Kimura T; Joshita S; Umemura T; Matsumoto A; Tanaka E
Clin J Gastroenterol, 10(5), 452-458, 2017年10月, 査読有り, 招待無し
責任著者 - Association between lower air pressure and the onset of ischemic colitis: a case-control study
Takefumi Kimura; Akihiro Shinji; Naoki Tanaka; Masayoshi Koinuma; Maki Yamaura; Tadanobu Nagaya; Satoru Joshita; Michiharu Komatsu; Takeji Umemura; Akira Horiuchi; Shuichi Wada; Eiji Tanaka
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 29(9), 1071-1078, 2017年09月, 査読有り, 招待無し
責任著者 - Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway
Shogo Takahashi; Naoki Tanaka; Srujana Golla; Tatsuki Fukami; Kristopher W. Krausz; Marianne A. Polunas; Blair C. Weig; Yusuke Masuo; Cen Xie; Changtao Jiang; Frank J. Gonzalez
TOXICOLOGICAL SCIENCES, 158(2), 334-346, 2017年08月, 査読有り, 招待無し - Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption
Haina Wang; Zhong-Ze Fang; Ran Meng; Yun-Feng Cao; Naoki Tanaka; Kristopher W. Krausz; Frank J. Gonzalez
TOXICOLOGY, 386, 133-142, 2017年07月, 査読有り, 招待無し - Decreased Fatty Acid beta-Oxidation Is the Main Cause of Fatty Liver Induced by Polyunsaturated Fatty Acid Deficiency in Mice
Takero Nakajima; Yang Yang; Yu Lu; Yuji Kamijo; Yosuke Yamada; Kozo Nakamura; Masahiro Koyama; Shohei Yamaguchi; Eiko Sugiyama; Naoki Tanaka; Toshifumi Aoyama
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 242(3), 229-239, 2017年07月, 査読有り, 招待無し - Successful Treatment for Chronic Hepatitis C-Autoimmune Hepatitis Overlap Syndrome due to Daclatasvir and Asunaprevir
Sugiura A; Wada S; Mori H; Kimura T; Matsuda Y; Tanaka N; Tanaka E; Kiyosawa K
Case Rep Gastroenterol, 11(2), 305-311, 2017年05月, 査読有り, 招待無し
責任著者 - Role of the lipid-regulated NF-kappa B/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury
Zhong-Ze Fang; Naoki Tanaka; Dan Lu; Chang-Tao Jiang; Wei-Hua Zhang; Chunze Zhang; Zuo Du; Zhi-Wei Fu; Peng Gao; Yun-Feng Cao; Hong-Zhi Sun; Zhi-Tu Zhu; Yan Cai; Kristopher W. Krausz; Zhi Yao; Frank J. Gonzalez
ARCHIVES OF TOXICOLOGY, 91(5), 2235-2244, 2017年05月, 査読有り, 招待無し - Clinicopathological characteristics of non-B non-C hepatocellular carcinoma without past hepatitis B virus infection
Takefumi Kimura; Akira Kobayashi; Naoki Tanaka; Kenji Sano; Michiharu Komatsu; Naoyuki Fujimori; Tomoo Yamazaki; Soichiro Shibata; Yuki Ichikawa; Satoru Joshita; Takeji Umemura; Akihiro Matsumoto; Akira Horiuchi; Hiromitsu Mori; Shuichi Wada; Kendo Kiyosawa; Shin-ichi Miyagawa; Eiji Tanaka
HEPATOLOGY RESEARCH, 47(5), 405-418, 2017年04月, 査読有り, 招待無し
責任著者 - Development of diffuse large B-cell lymphoma from follicular lymphoma of the duodenum: changes in endoscopic findings during a 6-year follow-up.
Hiroyuki Kitabatake; Tadanobu Nagaya; Naoki Tanaka; Hiroyoshi Ota; Kenji Sano; Naoko Asano; Tomoaki Suga; Yoshiyuki Nakamura; Taiji Akamatsu; Eiji Tanaka
Clinical journal of gastroenterology, 10(1), 79-85, 2017年02月, 査読有り - Massive ascites caused by intra-pancreatic arterioportal fistula: a rare complication of chronic pancreatitis.
Tomoo Yamazaki; Yasuhide Ochi; Naoki Tanaka; Takayuki Watanabe; Yugo Iwaya; Ayako Seki; Etsuo Hara; Eiji Tanaka; Tomoharu Watanabe; Shun Imai; Osamu Hasebe
Clinical journal of gastroenterology, 10(1), 73-78, 2017年02月, 査読有り
責任著者 - Association between endotoxemia and histological features of nonalcoholic fatty liver disease
Hiroyuki Kitabatake; Naoki Tanaka; Naoyuki Fujimori; Michiharu Komatsu; Ayaka Okubo; Kyogo Kakegawa; Takefumi Kimura; Ayumi Sugiura; Tomoo Yamazaki; Soichiro Shibata; Yuki Ichikawa; Satoru Joshita; Takeji Umemura; Akihiro Matsumoto; Masayoshi Koinuma; Kenji Sano; Toshifumi Aoyama; Eiji Tanaka
WORLD JOURNAL OF GASTROENTEROLOGY, 23(4), 712-722, 2017年01月, 査読有り, 招待無し
責任著者 - PPAR alpha protects against trans-fatty-acid-containing diet-induced steatohepatitis
Xiao Hu; Naoki Tanaka; Ran Guo; Yu Lu; Takero Nakajima; Frank J. Gonzalez; Toshifumi Aoyama
JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 39, 77-85, 2017年01月, 査読有り, 招待無し
責任著者 - Vonoprazan-Based Regimen Is More Useful than PPI-Based One as a First-Line Helicobacter pylori Eradication: A Randomized Controlled Trial
Masafumi Maruyama; Naoki Tanaka; Daisuke Kubota; Masayuki Miyajima; Takefumi Kimura; Koujiro Tokutake; Ryujiro Imai; Toru Fujisawa; Hiromitsu Mori; Yoshiaki Matsuda; Shuichi Wada; Akira Horiuchi; Kendo Kiyosawa
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, -, 2017年, 査読有り, 招待無し - PPAR alpha-dependent cholesterol/testosterone disruption in Leydig cells mediates 2,4-dichlorophenoxyacetic acid-induced testicular toxicity in mice
Yukiko Harada; Naoki Tanaka; Motoki Ichikawa; Yuji Kamijo; Eiko Sugiyama; Frank J. Gonzalez; Toshifumi Aoyama
ARCHIVES OF TOXICOLOGY, 90(12), 3061-3071, 2016年12月, 査読有り, 招待無し
筆頭著者, 責任著者 - Age-dependent PPAR alpha activation induces hepatic sulfatide accumulation in transgenic mice carrying the hepatitis C virus core gene
Yangyang Tian; Yang Yang; Xiaowei Zhang; Takero Nakajima; Naoki Tanaka; Eiko Sugiyama; Yuji Kamijo; Yu Lu; Kyoji Moriya; Kazuhiko Koike; Frank J. Gonzalez; Toshifumi Aoyama
GLYCOCONJUGATE JOURNAL, 33(6), 927-936, 2016年12月, 査読有り, 招待無し - Activation of PPAR alpha by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis
Yang Yang; Yuyao Feng; Xiaowei Zhang; Takero Nakajima; Naoki Tanaka; Eiko Sugiyama; Yuji Kamijo; Toshifumi Aoyama
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 240(2), 113-122, 2016年10月, 査読有り, 招待無し - Controlled attenuation parameter is correlated with actual hepatic fat content in patients with non-alcoholic fatty liver disease with none-to-mild obesity and liver fibrosis
Naoyuki Fujimori; Naoki Tanaka; Soichiro Shibata; Kenji Sano; Tomoo Yamazaki; Tomohiro Sekiguchi; Hiroyuki Kitabatake; Yuki Ichikawa; Takefumi Kimura; Michiharu Komatsu; Takeji Umemura; Akihiro Matsumoto; Eiji Tanaka
HEPATOLOGY RESEARCH, 46(10), 1019-1027, 2016年09月, 査読有り, 招待無し
責任著者 - Comparison between endoscopic mucosal resection and hot snare resection of large nonpedunculated colorectal polyps: a randomized trial
Akira Horiuchi; Toshiyuki Makino; Masashi Kajiyama; Naoki Tanaka; Kenji Sano; David Y. Graham
ENDOSCOPY, 48(7), 646-651, 2016年07月, 査読有り, 招待無し - Determination of the cut-off score of an endoscopic scoring method to predict whether elderly patients with dysphagia can eat pureed diets.
Torao Sakamoto; Akira Horiuchi; Toshiyuki Makino; Masashi Kajiyama; Naoki Tanaka; Masamitsu Hyodo
World journal of gastrointestinal endoscopy, 8(6), 288-94, 2016年03月, 査読有り - Irinotecan (CPT-11)-induced elevation of bile acids potentiates suppression of IL-10 expression
Fang, Zhong-Ze; Zhang, Dunfang; Cao, Yun-Feng; Xie, Cen; Lu, Dan; Sun, Dong-Xue; Tanaka, Naoki; Jiang, Changtao; Chen, Qianming; Chen, Yu; Wang, Haina; Gonzalez, Frank J.
TOXICOLOGY AND APPLIED PHARMACOLOGY, 291, 21-27, 2016年01月, 査読有り, 招待無し - Comparison of newly found polyps after removal of small colorectal polyps with cold or hot snare polypectomy
Horiuchi, Akira; Makino, Toshiyuki; Ichise, Yasuyuki; Kajiyama, Masashi; Kato, Naoyuki; Tanaka, Naoki
ACTA GASTRO-ENTEROLOGICA BELGICA, 78(4), 406-410, 2015年10月, 査読有り, 招待無し
最終著者 - Prospective, randomized comparison of 2 methods of cold snare polypectomy for small colorectal polyps
Akira Horiuchi; Kenji Hosoi; Masashi Kajiyama; Naoki Tanaka; Kenji Sano; David Y. Graham
GASTROINTESTINAL ENDOSCOPY, 82(4), 686-692, 2015年10月, 査読有り, 招待無し - Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans
Ming-Jiang Xu; Yan Cai; Hua Wang; Jose Altamirano; Binxia Chang; Adeline Bertola; Gemma Odena; Jim Lu; Naoki Tanaka; Kimihiko Matsusue; Tsutomu Matsubara; Partha Mukhopadhyay; Shioko Kimura; Pal Pacher; Frank J. Gonzalez; Ramon Bataller; Bin Gao
GASTROENTEROLOGY, 149(4), 1030-U367, 2015年10月, 査読有り, 招待無し - Metabolic mapping of A(3) adenosine receptor agonist MRS5980
Zhong-Ze Fang; Dilip K. Tosh; Naoki Tanaka; Haina Wang; Kristopher W. Krausz; Robert O'Connor; Kenneth A. Jacobson; Frank J. Gonzalez
BIOCHEMICAL PHARMACOLOGY, 97(2), 215-223, 2015年09月, 査読有り, 招待無し - St. John's Wort Attenuates Colorectal Carcinogenesis in Mice through Suppression of Inflammatory Signaling
Soumen K. Manna; Srujana Golla; Jaya Prakash Golla; Naoki Tanaka; Yan Cai; Shogo Takahashi; Kristopher W. Krausz; Tsutomu Matsubara; Ilia Korboukh; Frank J. Gonzalez
CANCER PREVENTION RESEARCH, 8(9), 786-795, 2015年09月, 査読有り, 招待無し - Primary hepatocellular carcinoma in a patient with neurofibromatosis type I
Takefumi Kimura; Naoki Tanaka; Takeji Umemura; Eiji Tanaka
LIVER INTERNATIONAL, 35(8), 2057-2058, 2015年08月, 査読有り, 招待無し - Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation
Limin Zhang; Robert G. Nichols; Jared Correll; Iain A. Murray; Naoki Tanaka; Philip B. Smith; Troy D. Hubbard; Aswathy Sebastian; Istvan Albert; Emmanuel Hatzakis; Frank J. Gonzalez; Gary H. Perdew; Andrew D. Patterson
ENVIRONMENTAL HEALTH PERSPECTIVES, 123(7), 679-688, 2015年07月, 査読有り, 招待無し - Role of fibroblast growth factor 21 in the early stage of NASH induced by methionine- and choline-deficient diet
Naoki Tanaka; Shogo Takahashi; Yuan Zhang; Kristopher W. Krausz; Philip B. Smith; Andrew D. Patterson; Frank J. Gonzalez
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1852(7), 1242-1252, 2015年07月, 査読有り, 招待無し
筆頭著者 - Mechanism of the development of nonalcoholic steatohepatitis after pancreaticoduodenectomy.
Nagaya T; Tanaka N; Kimura T; Kitabatake H; Fujimori N; Komatsu M; Horiuchi A; Yamaura T; Umemura T; Sano K; Gonzalez FJ; Aoyama T; Tanaka E
BBA Clin, 3, 168-74-74, 2015年02月, 査読有り, 招待無し
責任著者 - Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease.
Changtao Jiang; Cen Xie; Fei Li; Limin Zhang; Robert G Nichols; Kristopher W Krausz; Jingwei Cai; Yunpeng Qi; Zhong-Ze Fang; Shogo Takahashi; Naoki Tanaka; Dhimant Desai; Shantu G Amin; Istvan Albert; Andrew D Patterson; Frank J Gonzalez
The Journal of clinical investigation, 125(1), 386-402, 2015年01月, 査読有り - Adipocyte-specific Disruption of Fat-specific Protein 27 Causes Hepatosteatosis and Insulin Resistance in High-fat Diet-fed Mice
Naoki Tanaka; Shogo Takahashi; Tsutomu Matsubara; Changtao Jiang; Wataru Sakamoto; Tatyana Chanturiya; Ruifeng Teng; Oksana Gavrilova; Frank J. Gonzalez
JOURNAL OF BIOLOGICAL CHEMISTRY, 290(5), 3092-3105, 2015年01月, 査読有り, 招待無し
筆頭著者 - Helicobacter pylori-negative Differentiated Adenocarcinoma of the Stomach
Tadanobu Nagaya; Naoki Tanaka; Yugo Iwaya; Yoko Jimbo; Toshiharu Tatai; Tetsuya Ito; Ayako Seki; Kenichi Suzawa; Yasuhide Ochi; Etsuo Hara; Manabu Takata; Toshiaki Otsuki; Mai Iwaya; Noriko Hosaka; Norikazu Arakura; Eiji Tanaka; Osamu Hasebe
INTERNAL MEDICINE, 54(22), 2857-2862, 2015年, 査読有り, 招待無し - Activation of Intestinal Human Pregnane X Receptor Protects against Azoxymethane/Dextran Sulfate Sodium-Induced Colon Cancer
Jie Cheng; Zhong-Ze Fang; Kenjiro Nagaoka; Minoru Okamoto; Aijuan Qu; Naoki Tanaka; Shioko Kimura; Frank J. Gonzalez
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 351(3), 559-567, 2014年12月, 査読有り, 招待無し - Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-kappa B and STAT3 signaling
Aiming Liu; Naoki Tanaka; Lu Sun; Bin Guo; Jung-Hwan Kim; Kristopher W. Krausz; Zhongze Fang; Changtao Jiang; Julin Yang; Frank J. Gonzalez
CHEMICO-BIOLOGICAL INTERACTIONS, 223, 80-86, 2014年11月, 査読有り, 招待無し
筆頭著者 - Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet
Naoki Tanaka; Shogo Takahashi; Zhong-Ze Fang; Tsutomu Matsubara; Kristopher W. Krausz; Aijuan Qu; Frank J. Gonzalez
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1841(11), 1596-1607, 2014年11月, 査読有り, 招待無し
筆頭著者 - PPAR alpha-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate
Yunpeng Qi; Changtao Jiang; Naoki Tanaka; Kristopher W. Krausz; Chad N. Brocker; Zhong-Ze Fang; Bryce X. Bredell; Yatrik M. Shah; Frank J. Gonzalez
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 307(5), G564-G573, 2014年09月, 査読有り, 招待無し - Improving quality measures in colonoscopy and its therapeutic intervention
Akira Horiuchi; Naoki Tanaka
WORLD JOURNAL OF GASTROENTEROLOGY, 20(36), 13027-13034, 2014年09月, 査読有り, 招待無し
最終著者 - Biliary stenting as alternative therapy to stone clearance in elderly patients with bile duct stones
Horiuchi, Akira; Kajiyama, Masashi; Ichise, Yasuyuki; Tada, Haruyo; Fujiwara, Naoyuki; Tanaka, Naoki
ACTA GASTRO-ENTEROLOGICA BELGICA, 77(3), 297-301, 2014年09月, 査読有り, 招待無し
最終著者 - Laparoscopic findings of congenital hepatic fibrosis: A case report and review of the published work
Michiharu Komatsu; Naoki Tanaka; So-Ichirou Shibata; Takefumi Kimura; Yuki Ichikawa; Susumu Morita; Satoru Joshita; Tadanobu Nagaya; Takeji Umemura; Tetsuya Ichijo; Akihiro Matsumoto; Kaname Yoshizawa; Eiji Tanaka
HEPATOLOGY RESEARCH, 44(7), 818-824, 2014年07月, 査読有り, 招待無し
責任著者 - Herb-drug interaction prediction based on the high specific inhibition of andrographolide derivatives towards UDP-glucuronosyltransferase (UGT) 2B7
Hai-Ying Ma; Dong-Xue Sun; Yun-Feng Cao; Chun-Zhi Ai; Yan-Qing Qu; Cui-Min Hu; Changtao Jiang; Pei-Pei Dong; Xiao-Yu Sun; Mo Hong; Naoki Tanaka; Frank J. Gonzalez; Xiao-Chi Ma; Zhong-Ze Fang
TOXICOLOGY AND APPLIED PHARMACOLOGY, 277(1), 86-94, 2014年05月, 査読有り, 招待無し - Biomarkers of Coordinate Metabolic Reprogramming in Colorectal Tumors in Mice and Humans
Soumen K. Manna; Naoki Tanaka; Kristopher W. Krausz; Majda Haznadar; Xiang Xue; Tsutomu Matsubara; Elise D. Bowman; Eric R. Fearon; Curtis C. Harris; Yatrik M. Shah; Frank J. Gonzalez
GASTROENTEROLOGY, 146(5), 1313-1324, 2014年05月, 査読有り, 招待無し - In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract
Zhong-Ze Fang; Kristopher W. Krausz; Kenjiro Nagaoka; Naoki Tanaka; Krishne Gowda; Shantu G. Amin; Gary H. Perdew; Frank J. Gonzalez
BRITISH JOURNAL OF PHARMACOLOGY, 171(7), 1735-1746, 2014年04月, 査読有り, 招待無し - Removal of small colorectal polyps in anticoagulated patients: a prospective randomized comparison of cold snare and conventional polypectomy
Akira Horiuchi; Yoshiko Nakayama; Masashi Kajiyama; Naoki Tanaka; Kenji Sano; David Y. Graham
GASTROINTESTINAL ENDOSCOPY, 79(3), 417-423, 2014年03月, 査読有り, 招待無し - Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice
Jie Cheng; Zhong-Ze Fang; Jung-Hwan Kim; Kristopher W. Krausz; Naoki Tanaka; John Y. L. Chiang; Frank J. Gonzalez
JOURNAL OF LIPID RESEARCH, 55(3), 455-465, 2014年03月, 査読有り, 招待無し - Chronic ethanol consumption decreases serum sulfatide levels by suppressing hepatic cerebroside sulfotransferase expression in mice
Hiroki Kanbe; Yuji Kamijo; Takero Nakajima; Naoki Tanaka; Eiko Sugiyama; Lixuan Wang; Zhong-Ze Fang; Atsushi Hara; Frank J. Gonzalez; Toshifumi Aoyama
ARCHIVES OF TOXICOLOGY, 88(2), 367-379, 2014年02月, 招待無し
責任著者 - Role of Myc in hepatocellular proliferation and hepatocarcinogenesis
Aijuan Qu; Changtao Jiang; Yan Cai; Jung-Hwan Kim; Naoki Tanaka; Jerrold M. Ward; Yatrik M. Shah; Frank J. Gonzalez
JOURNAL OF HEPATOLOGY, 60(2), 331-338, 2014年02月, 査読有り, 招待無し - Steatogenesis in adult-onset type II citrullinemia is associated with down-regulation of PPAR alpha
Komatsu, Michiharu; Kimura, Takefumi; Yazaki, Masahide; Tanaka, Naoki; Yang, Yang; Nakajima, Takero; Horiuchi, Akira; Fang, Zhong-Ze; Joshita, Satoru; Matsumoto, Akihiro; Umemura, Takeji; Tanaka, Eiji; Gonzalez, Frank J.; Ikeda, Shu-Ichi; Aoyama, Toshifumi
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 60(3), 819A-819A, 2014年, 査読有り, 招待無し
責任著者 - A model of in vitro UDP-glucuronosyltransferase inhibition by bile acids predicts possible metabolic disorders
Zhong-Ze Fang; Rong-Rong He; Yun-Feng Cao; Naoki Tanaka; Changtao Jiang; Kristopher W. Krausz; Yunpeng Qi; Pei-Pei Dong; Chun-Zhi Ai; Xiao-Yu Sun; Mo Hong; Guang-Bo Ge; Frank J. Gonzalez; Xiao-Chi Ma; Hong-Zhi Sun
JOURNAL OF LIPID RESEARCH, 54(12), 3334-3344, 2013年12月, 査読有り, 招待無し - Metabolomics reveals trichloroacetate as a major contributor to trichloroethylene-induced metabolic alterations in mouse urine and serum
Zhong-Ze Fang; Kristopher W. Krausz; Naoki Tanaka; Fei Li; Aijuan Qu; Jeffrey R. Idle; Frank J. Gonzalez
ARCHIVES OF TOXICOLOGY, 87(11), 1975-1987, 2013年11月, 査読有り, 招待無し - Peroxisome proliferator-activated receptor α mediates enhancement of gene expression of cerebroside sulfotransferase in several murine organs
Takero Nakajima; Yuji Kamijo; Huang Yuzhe; Takefumi Kimura; Naoki Tanaka; Eiko Sugiyama; Kozo Nakamura; Mamoru Kyogashima; Atsushi Hara; Toshifumi Aoyama
Glycoconjugate Journal, 30(6), 553-560, 2013年08月, 査読有り, 招待無し - Elemental diets may reduce the risk of aspiration pneumonia in bedridden gastrostomy-fed patients.
Akira Horiuchi; Yoshiko Nakayama; Ryosei Sakai; Manabu Suzuki; Masashi Kajiyama; Naoki Tanaka
The American journal of gastroenterology, 108(5), 804-10, 2013年05月, 査読有り
最終著者 - Safety and Effectiveness of Low-Dose Propofol Sedation During and After Esophagogastroduodenoscopy in Child A and B Cirrhotic Patients
Naoki Tanaka; Akira Horiuchi; Yoshiko Nakayama; Yoshihiko Katsuyama; Masatsugu Isobe; Toshifumi Aoyama; Eiji Tanaka; Shigeru Ohmori
DIGESTIVE DISEASES AND SCIENCES, 58(5), 1383-1389, 2013年05月, 査読有り, 招待無し
筆頭著者 - Benefits and limitations of cap-fitted colonoscopy in screening colonoscopy.
Akira Horiuchi; Yoshiko Nakayama; Masashi Kajiyama; Naoyuki Kato; Yasuyuki Ichise; Naoki Tanaka
Digestive diseases and sciences, 58(2), 534-9, 2013年02月, 査読有り
最終著者 - TGF-beta-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury
Tsutomu Matsubara; Naoki Tanaka; Misako Sato; Dong Wook Kang; Kristopher W. Krausz; Kathleen C. Flanders; Kazuo Ikeda; Hans Luecke; Lalage M. Wakefield; Frank J. Gonzalez
JOURNAL OF LIPID RESEARCH, 53(12), 2698-2707, 2012年12月, 査読有り, 招待無し - Metabolic map and bioactivation of the anti-tumour drug noscapine.
Zhong-Ze Fang; Kristopher W Krausz; Fei Li; Jie Cheng; Naoki Tanaka; Frank J Gonzalez
British journal of pharmacology, 167(6), 1271-86, 2012年11月, 査読有り - Metabolomics Identifies an Inflammatory Cascade Involved in Dioxin- and Diet-Induced Steatohepatitis
Tsutomu Matsubara; Naoki Tanaka; Kristopher W. Krausz; Soumen K. Manna; Dong Wook Kang; Erik R. Anderson; Hans Luecke; Andrew D. Patterson; Yatrik M. Shah; Frank J. Gonzalez
CELL METABOLISM, 16(5), 634-644, 2012年11月, 査読有り, 招待無し
筆頭著者 - Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice.
Jie Cheng; Kristopher W Krausz; Naoki Tanaka; Frank J Gonzalez
Toxicological sciences : an official journal of the Society of Toxicology, 129(2), 456-68, 2012年10月, 査読有り - Colonoscopic enema as rescue for inadequate bowel preparation before colonoscopy: a prospective, observational study
A. Horiuchi; Y. Nakayama; M. Kajiyama; N. Kato; T. Kamijima; Y. Ichise; N. Tanaka
Colorectal Disease, 14(10), 2012年09月, 査読有り
最終著者 - Invasive colorectal cancer within 5 years of negative colonoscopy in a Japanese population
A. Horiuchi; Y. Nakayama; M. Kajiyama; T. Kamijima; N. Tanaka
Colorectal Disease, 14(9), 1090-1094, 2012年08月, 査読有り
最終著者 - Long-term outcome of Japanese patients with type 1 autoimmune hepatitis.
Kaname Yoshizawa; Akihiro Matsumoto; Tetsuya Ichijo; Takeji Umemura; Satoru Joshita; Michiharu Komatsu; Naoki Tanaka; Eiji Tanaka; Masao Ota; Yoshihiko Katsuyama; Kendo Kiyosawa; Masanori Abe; Morikazu Onji
Hepatology (Baltimore, Md.), 56(2), 668-76, 2012年08月, 査読有り - Metabolomics reveals an essential role for peroxisome proliferator-activated receptor alpha in bile acid homeostasis
Fei Li; Andrew D. Patterson; Kristopher W. Krausz; Naoki Tanaka; Frank J. Gonzalez
JOURNAL OF LIPID RESEARCH, 53(8), 1625-1635, 2012年08月, 査読有り, 招待無し - Safety and effectiveness of propofol sedation during and after outpatient colonoscopy.
Akira Horiuchi; Yoshiko Nakayama; Masashi Kajiyama; Naoyuki Kato; Tetsuya Kamijima; Yasuyuki Ichise; Naoki Tanaka
World journal of gastroenterology, 18(26), 3420-5, 2012年07月, 査読有り
最終著者 - Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis
Naoki Tanaka; Tsutomu Matsubara; Kristopher W. Krausz; Andrew D. Patterson; Frank J. Gonzalez
HEPATOLOGY, 56(1), 118-129, 2012年07月, 査読有り, 招待無し
筆頭著者 - The modulation of hepatic adenosine triphosphate and inflammation by eicosapentaenoic acid during severe fibrotic progression in the SHRSP5/Dmcr rat model.
Xiaofang Jia; Hisao Naito; Husna Yetti; Hazuki Tamada; Kazuya Kitamori; Yumi Hayashi; Nozomi Yamagishi; Dong Wang; Yukie Yanagiba; Yuki Ito; Juncai Wang; Naoki Tanaka; Katsumi Ikeda; Yukio Yamori; Tamie Nakajima
Life sciences, 90(23-24), 934-43, 2012年06月, 査読有り - Clinical Characteristics of Young-Onset Ischemic Colitis
Takefumi Kimura; Akihiro Shinji; Akira Horiuchi; Naoki Tanaka; Tadanobu Nagaya; Takashi Shigeno; Naoshi Nakamura; Michiharu Komatsu; Takeji Umemura; Norikazu Arakura; Akihiro Matsumoto; Eiji Tanaka
DIGESTIVE DISEASES AND SCIENCES, 57(6), 1652-1659, 2012年06月, 査読有り, 招待無し
責任著者 - Attenuation of kidney injuries maintains serum sulfatide levels dependent on hepatic synthetic ability: a possible involvement of oxidative stress.
Xiaona Sheng; Takero Nakajima; Lixuan Wang; Xiaowei Zhang; Yuji Kamijo; Kyoko Takahashi; Naoki Tanaka; Eiko Sugiyama; Mamoru Kyogashima; Toshifumi Aoyama; Atsushi Hara
The Tohoku journal of experimental medicine, 227(1), 1-12, 2012年05月, 査読有り, 招待無し - Endoscopic decompression of benign large bowel obstruction using a transanal drainage tube
A. Horiuchi; Y. Nakayama; M. Kajiyama; T. Kamijima; N. Kato; Y. Ichise; N. Tanaka
Colorectal Disease, 14(5), 623-627, 2012年03月, 査読有り
最終著者 - Psychomotor recovery and blood propofol level in colonoscopy when using propofol sedation.
Akira Horiuchi; Yoshiko Nakayama; Hideyasu Fujii; Yoshihiko Katsuyama; Shigeru Ohmori; Naoki Tanaka
Gastrointestinal endoscopy, 75(3), 506-12, 2012年03月, 査読有り
最終著者 - PPAR alpha is down-regulated following liver transplantation in mice
Kan Nakagawa; Naoki Tanaka; Miwa Morita; Atsushi Sugioka; Shin-ichi Miyagawa; Frank J. Gonzalez; Toshifumi Aoyama
JOURNAL OF HEPATOLOGY, 56(3), 586-594, 2012年03月, 査読有り, 招待無し
筆頭著者, 責任著者 - Effectiveness of outpatient percutaneous endoscopic gastrostomy replacement using esophagogastroduodenoscopy and propofol sedation.
Akira Horiuchi; Yoshiko Nakayama; Masashi Kajiyama; Naoki Tanaka
World journal of gastrointestinal endoscopy, 4(2), 45-9, 2012年02月, 査読有り
最終著者 - Modulation of ammonium perfluorooctanoate-induced hepatic damage by genetically different PPARα in mice.
Tomohiko Nakagawa; Doni Hikmat Ramdhan; Naoki Tanaka; Hisao Naito; Hazuki Tamada; Yuki Ito; Yufei Li; Yumi Hayashi; Nozomi Yamagishi; Yukie Yanagiba; Toshifumi Aoyama; Frank J Gonzalez; Tamie Nakajima
Archives of toxicology, 86(1), 63-74, 2012年01月, 査読有り - Hepatic Cerebroside Sulfotransferase Is Induced by PPARα Activation in Mice.
Takefumi Kimura; Takero Nakajima; Yuji Kamijo; Naoki Tanaka; Lixuan Wang; Atsushi Hara; Eiko Sugiyama; Eiji Tanaka; Frank J Gonzalez; Toshifumi Aoyama
PPAR research, 2012, 174932-174932, 2012年, 査読有り - Fatty Acid Accumulation and Resulting PPARα Activation in Fibroblasts due to Trifunctional Protein Deficiency.
Masato Wakabayashi; Yuji Kamijo; Takero Nakajima; Naoki Tanaka; Eiko Sugiyama; Tian Yangyang; Takefumi Kimura; Toshifumi Aoyama
PPAR research, 2012, 371691-371691, 2012年, 査読有り - Clinical characteristics of de novo nonalcoholic fatty liver disease following pancreaticoduodenectomy
Naoki Tanaka; Akira Horiuchi; Takahide Yokoyama; Gengo Kaneko; Naoto Horigome; Takahiro Yamaura; Tadanobu Nagaya; Michiharu Komatsu; Kenji Sano; Shin-ichi Miyagawa; Toshifumi Aoyama; Eiji Tanaka
JOURNAL OF GASTROENTEROLOGY, 46(6), 758-768, 2011年06月, 査読有り, 招待無し
筆頭著者, 責任著者 - Lithocholic Acid Disrupts Phospholipid and Sphingolipid Homeostasis Leading to Cholestasis in Mice
Tsutomu Matsubara; Naoki Tanaka; Andrew D. Patterson; Joo-Youn Cho; Kristopher W. Krausz; Frank J. Gonzalez
HEPATOLOGY, 53(4), 1282-1293, 2011年04月, 査読有り, 招待無し - Prospective randomized comparison of cold snare polypectomy and conventional polypectomy for small colorectal polyps.
Yasuyuki Ichise; Akira Horiuchi; Yoshiko Nakayama; Naoki Tanaka
Digestion, 84(1), 78-81, 2011年, 査読有り
最終著者 - Accurate and simple method for quantification of hepatic fat content using magnetic resonance imaging: a prospective study in biopsy-proven nonalcoholic fatty liver disease
Tomoko Hatta; Yasunari Fujinaga; Masumi Kadoya; Hitoshi Ueda; Hiroaki Murayama; Masahiro Kurozumi; Kazuhiko Ueda; Michiharu Komatsu; Tadanobu Nagaya; Satoru Joshita; Ryo Kodama; Eiji Tanaka; Tsuyoshi Uehara; Kenji Sano; Naoki Tanaka
JOURNAL OF GASTROENTEROLOGY, 45(12), 1263-1271, 2010年12月, 査読有り, 招待無し
最終著者 - Differential response to trichloroethylene-induced hepatosteatosis in wild-type and PPARalpha-humanized mice.
Doni Hikmat Ramdhan; Michihiro Kamijima; Dong Wang; Yuki Ito; Hisao Naito; Yukie Yanagiba; Yumi Hayashi; Naoki Tanaka; Toshifumi Aoyama; Frank J Gonzalez; Tamie Nakajima
Environmental health perspectives, 118(11), 1557-63, 2010年11月, 査読有り - Eicosapentaenoic acid improves hepatic steatosis independent of PPAR alpha activation through inhibition of SREBP-1 maturation in mice
Naoki Tanaka; Xiuguo Zhang; Eiko Sugiyama; Hiroyuki Kono; Akira Horiuchi; Takero Nakajima; Hiroki Kanbe; Eiji Tanaka; Frank J. Gonzalez; Toshifumi Aoyama
BIOCHEMICAL PHARMACOLOGY, 80(10), 1601-1612, 2010年11月, 査読有り, 招待無し
筆頭著者 - Techniques and Outcomes of Endoscopic Decompression Using Transanal Drainage Tube Placement for Acute Left-sided Colorectal Obstruction.
Yasuyuki Ichise; Akira Horiuchi; Yoshiko Nakayama; Naoki Tanaka
Gastroenterology research, 3(5), 201-206, 2010年10月, 査読有り
最終著者 - Association between serum uric acid levels and cardiometabolic risk factors among Japanese junior high school students.
Minoru Hongo; Hiroya Hidaka; Shigeko Sakaguchi; Keisuke Nakanishi; Motoki Ichikawa; Naoko Hirota; Naoki Tanaka; Goro Tsuruta; Yoshikazu Yazaki; Osamu Kinoshita; Uichi Ikeda; Kenichi Koike
Circulation journal : official journal of the Japanese Circulation Society, 74(8), 1570-7, 2010年08月, 査読有り - Effect of Traditional Japanese Medicine, Daikenchuto (TJ-100) in Patients With Chronic Constipation.
Akira Horiuchi; Yoshiko Nakayama; Naoki Tanaka
Gastroenterology research, 3(4), 151-155, 2010年08月, 査読有り
最終著者 - Serum Fragmented Cytokeratin 18 Levels Reflect the Histologic Activity Score of Nonalcoholic Fatty Liver Disease More Accurately Than Serum Alanine Aminotransferase Levels
Masaru Tsutsui; Naoki Tanaka; Masatomo Kawakubo; Yo Sheena; Akira Horiuchi; Michiharu Komatsu; Tadanobu Nagaya; Satoru Joshita; Takeji Umemura; Tetsuya Ichijo; Akihiro Matsumoto; Kaname Yoshizawa; Toshifumi Aoyama; Eiji Tanaka; Kenji Sano
JOURNAL OF CLINICAL GASTROENTEROLOGY, 44(6), 440-447, 2010年07月, 査読有り, 招待無し
筆頭著者, 責任著者 - Twenty- or 24F-diameter dilation prevents severe bleeding associated with 27F-diameter dilation for direct percutaneous endoscopic gastrostomy tube placement
Akira Horiuchi; Yoshiko Nakayama; Naoki Tanaka
Gastroenterology Insights, 2(1), 8-8, 2010年06月, 査読有り
最終著者 - Biliary stenting in the management of large or multiple common bile duct stones.
Akira Horiuchi; Yoshiko Nakayama; Masashi Kajiyama; Naoyuki Kato; Tetsuya Kamijima; David Y Graham; Naoki Tanaka
Gastrointestinal endoscopy, 71(7), 1200-1203, 2010年06月, 査読有り
最終著者 - Nonalcoholic fatty liver disease in Japanese junior high school students: its prevalence and relationship to lifestyle habits
Goro Tsuruta; Naoki Tanaka; Minoru Hongo; Michiharu Komatsu; Akira Horiuchi; Kaeko Hamamoto; Chieko Iguchi; Yoshiko Nakayama; Takeji Umemura; Tetsuya Ichijo; Akihiro Matsumoto; Kaname Yoshizawa; Toshifumi Aoyama; Eiji Tanaka
JOURNAL OF GASTROENTEROLOGY, 45(6), 666-672, 2010年06月, 査読有り, 招待無し
筆頭著者, 責任著者 - Hood-assisted colonoscopy is more effective in detection of colorectal adenomas than narrow-band imaging.
Akira Horiuchi; Yoshiko Nakayama; Naoyuki Kato; Yasuyuki Ichise; Masashi Kajiyama; Naoki Tanaka
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 8(4), 379-83, 2010年04月, 査読有り
最終著者 - Multiple roles of PPARalpha in brown adipose tissue under constitutive and cold conditions.
Makiko Komatsu; Yuhong Tong; Yufeng Li; Takero Nakajima; Gang Li; Rui Hu; Eiko Sugiyama; Yuji Kamijo; Naoki Tanaka; Atsushi Hara; Toshifumi Aoyama
Genes to cells : devoted to molecular & cellular mechanisms, 15(2), 91-100, 2010年02月, 査読有り - Effect of bezafibrate on hepatic oxidative stress: comparison between conventional experimental doses and clinically-relevant doses in mice.
Takero Nakajima; Naoki Tanaka; Gang Li; Rui Hu; Yuji Kamijo; Atsushi Hara; Toshifumi Aoyama
Redox report : communications in free radical research, 15(3), 123-30, 2010年, 査読有り
責任著者 - Conventional Diet Therapy for Hyperammonemia is Risky in the Treatment of Hepatic Encephalopathy Associated with Citrin Deficiency
Fukushima, Kazuhiro; Yazaki, Masahide; Nakamura, Mio; Tanaka, Naoki; Kobayashi, Keiko; Saheki, Takeyori; Takei, Hideki; Ikeda, Shu-ichi
INTERNAL MEDICINE, 49(3), 243-247, 2010年, 査読有り, 招待無し - Down-regulation of SREBP-1c is associated with the development of burned-out NASH
Nagaya, Tadanobu; Tanaka, Naoki; Suzuki, Takefumi; Sano, Kenji; Horiuchi, Akira; Komatsu, Michiharu; Nakajima, Takero; Nishizawa, Tomoko; Joshita, Satoru; Umemura, Takeji; Ichijo, Tetsuya; Matsumoto, Akihiro; Yoshizawa, Kaname; Nakayama, Jun; Tanaka, Eiji; Aoyama, Toshifumi
JOURNAL OF HEPATOLOGY, 52(4), S373-S374, 2010年, 査読有り, 招待無し
筆頭著者, 責任著者 - Low-dose propofol sedation for diagnostic esophagogastroduodenoscopy: results in 10,662 adults.
Akira Horiuchi; Yoshiko Nakayama; Nao Hidaka; Yasuyuki Ichise; Masashi Kajiyama; Naoki Tanaka
The American journal of gastroenterology, 104(7), 1650-5, 2009年07月, 査読有り
最終著者 - 一般中学生の高尿酸血症と生活習慣病との関連
本郷 実; 日高 宏哉; 阪口 しげ子; 市川 元基; 池田 宇一; 田中 直樹; 鶴田 悟郎; 小池 健一
痛風と核酸代謝 = Gout and nucleic acid metabolism, 33(1), 17-26, 2009年07月, 査読有り, 招待無し - Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections
Naoki Tanaka; Akira Horiuchi; Takahiro Yamaura; Michiharu Komatsu; Takahide Yokoyama; Shinji Okaniwa; Tadanobu Nagaya; Kaname Yoshizawa; Kendo Kiyosawa; Toshifumi Aoyama; Eiji Tanaka
JOURNAL OF GASTROENTEROLOGY, 44(6), 577-582, 2009年06月, 査読有り, 招待無し
筆頭著者, 責任著者 - Polyenephosphatidylcholine prevents alcoholic liver disease in PPAR alpha-null mice through attenuation of increases in oxidative stress
Wataru Okiyama; Naoki Tanaka; Tamie Nakajima; Eiji Tanaka; Kendo Kiyosawa; Frank J. Gonzalez; Toshifumi Aoyama
JOURNAL OF HEPATOLOGY, 50(6), 1236-1246, 2009年06月, 査読有り, 招待無し
筆頭著者, 責任著者 - Bezafibrate at Clinically Relevant Doses Decreases Serum/Liver Triglycerides via Down-Regulation of Sterol Regulatory Element-Binding Protein-1c in Mice: A Novel Peroxisome Proliferator-Activated Receptor alpha-Independent Mechanism
Takero Nakajima; Naoki Tanaka; Hiroki Kanbe; Atsushi Hara; Yuji Kamijo; Xiaowei Zhang; Frank J. Gonzalez; Toshifumi Aoyama
MOLECULAR PHARMACOLOGY, 75(4), 782-792, 2009年04月, 査読有り, 招待無し
責任著者 - Hepatitis C Virus, Splenic Vein Thrombosis, and Lymphoma
Naoki Tanaka; Takahide Yokoyama; Akira Horiuchi
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 7(2), XXIV-XXIV, 2009年02月, 査読有り, 招待無し
筆頭著者, 責任著者 - 広範囲の肝実質の脱落により奇異な肝形態を呈し自己免疫性肝炎が疑われた1例
城下 智; 一條 哲也; 吉澤 要; 福島 万奈; 小松 通治; 新井 薫; 田中 直樹; 梅村 武司; 松本 晶博; 田中 榮司
日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy, 51(1), 48-54, 2009年01月, 査読有り, 招待無し - Prospective comparison between sedated high-definition oral and unsedated ultrathin transnasal esophagogastroduodenoscopy in the same subjects: pilot study.
Akira Horiuchi; Yoshiko Nakayama; Nao Hidaka; Yasuyuki Ichise; Masashi Kajiyama; Naoki Tanaka
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 21(1), 24-8, 2009年01月, 査読有り
最終著者 - Primitive Neuroectodermal Tumor as a Differential Diagnosis of CD56-Positive Tumors in Adults
Nagaya, Tadanobu; Tanaka, Naoki; Kamijo, Atsushi; Joshita, Satoru; Nakazawa, Koh; Miyabayashi, Hideharu; Yoneda, Suguru; Ito, Tetsuya; Komatsu, Michiharu; Tanaka, Eiji; Kitano, Kiyoshi
INTERNAL MEDICINE, 48(15), 1267-1272, 2009年, 査読有り, 招待無し
責任著者 - Pretreatment prediction of virological response to peginterferon plus ribavirin therapy in chronic hepatitis C patients using viral and host factors.
Haruaki Shirakawa; Akihiro Matsumoto; Satoru Joshita; Michiharu Komatsu; Naoki Tanaka; Takeji Umemura; Tetsuya Ichijo; Kaname Yoshizawa; Kendo Kiyosawa; Eiji Tanaka
Hepatology (Baltimore, Md.), 48(6), 1753-60, 2008年12月, 査読有り - α型ペルオキシソーム増殖剤活性化受容体（PPARα）： 脂肪肝疾患との関連
田中直樹,青山俊文
信州医学雑誌, 56(6), 347-358, 2008年12月, 査読有り, 招待無し
筆頭著者, 責任著者 - Citrin deficiency as a cause of chronic liver disorder mimicking non-alcoholic fatty liver disease
Michiharu Komatsu; Masahide Yazaki; Naoki Tanaka; Kenji Sano; Etsuko Hashimoto; Yo-ichi Taker; Yuan-Zong Song; Eiji Tanaka; Kendo Kiyosawa; Takeyori Saheki; Toshifumi Aoyama; Keiko Kobayashi
JOURNAL OF HEPATOLOGY, 49(5), 810-820, 2008年11月, 査読有り, 招待無し
責任著者 - Development from simple steatosis to liver cirrhosis and hepatocellular carcinoma: a 27-year follow-up case.
Tadanobu Nagaya; Naoki Tanaka; Michiharu Komatsu; Tetsuya Ichijo; Kenji Sano; Akira Horiuchi; Satoru Joshita; Takeji Umemura; Akihiro Matsumoto; Kaname Yoshizawa; Toshifumi Aoyama; Kendo Kiyosawa; Eiji Tanaka
Clinical journal of gastroenterology, 1(3), 116-121, 2008年10月, 査読有り
責任著者 - Transgastric Diversion of Transnasal Long Tube Placement Using a Percutaneous Endoscopic Gastrostomy Site in a Patient with Bowel Obstruction and Massive Ascites due to Ovarian Carcinoma.
Akira Horiuchi; Yoshiko Nakayama; Naoki Tanaka
Case reports in gastroenterology, 2(3), 326-9, 2008年09月, 査読有り
最終著者 - Prospective randomized trial comparing the direct method using a 24 Fr bumper-button-type device with the pull method for percutaneous endoscopic gastrostomy
A. Horiuchi; Y. Nakayama; N. Tanaka; H. Fujii; M. Kajiyama
Endoscopy, 40(09), 722-726, 2008年09月, 査読有り - Insulin resistance and hepatitis C virus: a case-control study of non-obese, non-alcoholic and non-steatotic hepatitis virus carriers with persistently normal serum aminotransferase
Naoki Tanaka; Tadanobu Nagaya; Michiharu Komatsu; Akira Horiuchi; Goro Tsuruta; Haruaki Shirakawa; Takeji Umemura; Tetsuya Ichijo; Akihiro Matsumoto; Kaname Yoshizawa; Toshifumi Aoyama; Kendo Kiyosawa; Eiji Tanaka
LIVER INTERNATIONAL, 28(8), 1104-1111, 2008年09月, 査読有り, 招待無し
筆頭著者, 責任著者 - Eicosapentaenoic acid lowers plasma and liver cholesterol levels in the presence of peroxisome proliferators-activated receptor alpha.
Eiko Sugiyama; Yasuko Ishikawa; Yufeng Li; Tomoko Kagai; Misaki Nobayashi; Naoki Tanaka; Yuji Kamijo; Shin Yokoyama; Atsushi Hara; Toshifumi Aoyama
Life sciences, 83(1-2), 19-28, 2008年07月, 査読有り - Cholesterol-lowering effect of bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice
Takero Nakajima; Naoki Tanaka; Eiko Sugiyama; Yuji Kamijo; Atsushi Hara; Rui Hu; Gang Li; Yufeng Li; Kozo Nakamura; Frank J. Gonzalez; Toshifumi Aoyama
BIOCHEMICAL PHARMACOLOGY, 76(1), 108-119, 2008年07月, 査読有り, 招待無し
責任著者 - Molecular mechanism of age-specific hepatic lipid accumulation in PPARalpha (+/-):LDLR (+/-) mice, an obese mouse model.
Yufeng Li; Eiko Sugiyama; Shin Yokoyama; Lingling Jiang; Naoki Tanaka; Toshifumi Aoyama
Lipids, 43(4), 301-12, 2008年04月, 査読有り - Highly purified eicosapentaenoic acid treatment improves nonalcoholic steatohepatitis
Tanaka, Naoki; Sano, Kenji; Horiuchi, Akira; Tanaka, Eiji; Kiyosawa, Kendo; Aoyama, Toshifumi
JOURNAL OF CLINICAL GASTROENTEROLOGY, 42(4), 413-418, 2008年04月, 査読有り, 招待無し
筆頭著者, 責任著者 - PPAR alpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in mice
Naoki Tanaka; Kyoji Moriya; Kendo Kiyosawa; Kazuhiko Koike; Frank J. Gonzalez; Toshifurni Aoyama
JOURNAL OF CLINICAL INVESTIGATION, 118(2), 683-694, 2008年02月, 査読有り, 招待無し
筆頭著者, 責任著者 - Pancreatic exocrine insufficiency: A rare cause of nonalcoholic steatohepatitis
Tanaka, Naoki; Horiuchi, Akira; Yokoyama, Takahide; Kawa, Shigeyuki; Kiyosawa, Kendo
AMERICAN JOURNAL OF GASTROENTEROLOGY, 103(1), 245-246, 2008年01月, 査読有り, 招待無し
筆頭著者, 責任著者 - Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: Implications for HCV-associated hepatocarcinogenesis
Naoki Tanaka; Kyoji Moriya; Kendo Kiyosawa; Kazuhiko Koike; Toshifumi Aoyama
INTERNATIONAL JOURNAL OF CANCER, 122(1), 124-131, 2008年01月, 査読有り, 招待無し
筆頭著者, 責任著者 - Propofol sedation for endoscopic procedures in patients 90 years of age and older.
Akira Horiuchi; Yoshiko Nakayama; Naoki Tanaka; Yasuyuki Ichise; Yoshihiko Katsuyama; Shigeru Ohmori
Digestion, 78(1), 20-3, 2008年, 査読有り - Safety and driving ability following low-dose propofol sedation.
Akira Horiuchi; Yoshiko Nakayama; Yoshihiko Katsuyama; Shigeru Ohmori; Yasuyuki Ichise; Naoki Tanaka
Digestion, 78(4), 190-4, 2008年, 査読有り
最終著者 - 腹壁への浸潤が疑われ, 画像検査が診断の契機となった肝放線菌症の1例
武藤 英知; 一條 哲也; 小林 倫子; 田中 直樹; 梅村 武司; 小松 通治; 松本 晶博; 吉澤 要; 田中 榮司; 上田 和彦; 角谷 眞澄; 清澤 研道
肝臓 = ACTA HEPATOLOGICA JAPONICA, 48(11), 553-558, 2007年11月, 査読有り, 招待無し - Differential effects of aging, drinking and exercise on serum cholesterol levels dependent on the PPARA-V227A polymorphism.
Hisao Naito; Michihiro Kamijima; Osamu Yamanoshita; Ai Nakahara; Takahiko Katoh; Naoki Tanaka; Toshifumi Aoyama; Frank J Gonzalez; Tamie Nakajima
Journal of occupational health, 49(5), 353-62, 2007年09月, 査読有り - Effect of precut sphincterotomy on biliary cannulation based on the characteristics of the major duodenal papilla.
Akira Horiuchi; Yoshiko Nakayama; Masashi Kajiyama; Naoki Tanaka
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 5(9), 1113-8, 2007年09月, 査読有り
最終著者 - A lean man with nonalcoholic fatty liver disease
Naoki Tanaka; Masahide Yazaki; Keiko Kobayashi
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 5(3), XXXII-XXXII, 2007年03月, 査読有り, 招待無し
筆頭著者, 責任著者 - Efficacy and safety of 6-month iron reduction therapy in patients with hepatitis C virus-related cirrhosis: a pilot study
Naoki Tanaka; Akira Horiuchi; Takahiro Yamaura; Michiharu Komatsu; Eiji Tanaka; Kendo Kiyosawa
JOURNAL OF GASTROENTEROLOGY, 42(1), 49-55, 2007年01月, 査読有り, 招待無し
筆頭著者, 責任著者 - Useful parameters for distinguishing nonalcoholic steatohepatitis with mild steatosis from cryptogenic chronic hepatitis in the Japanese population
Naoki Tanaka; Eiji Tanaka; Yo Sheena; Michiharu Komatsu; Wataru Okiyama; Noriko Misawa; Hidetomo Muto; Takeji Umemura; Tetsuya Ichijo; Akihiro Matsumoto; Kaname Yoshizawa; Akira Horiuchi; Kendo Kiyosawa
LIVER INTERNATIONAL, 26(8), 956-963, 2006年10月, 査読有り, 招待無し
筆頭著者, 責任著者 - Peroxisome proliferator-activated receptor alpha-independent peroxisome proliferation
Xiuguo Zhang; Naoki Tanaka; Takero Nakajuna; Yuji Kamijo; Frank J. Gonzalez; Toshifumi Aoyama
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 346(4), 1307-1311, 2006年08月, 査読有り, 招待無し
責任著者 - Nasopharyngeal decolonization of methicillin-resistant Staphylococcus aureus can reduce PEG peristomal wound infection.
Akira Horiuchi; Yoshiko Nakayama; Masashi Kajiyama; Hideyasu Fujii; Naoki Tanaka
The American journal of gastroenterology, 101(2), 274-7, 2006年02月, 査読有り
最終著者 - Laparoscopic findings in patients with nonalcoholic steatohepatitis
N Tanaka; T Ichijo; W Okiyama; H Mutou; N Misawa; A Matsumoto; K Yoshizawa; E Tanaka; K Kiyosawa
LIVER INTERNATIONAL, 26(1), 32-38, 2006年02月, 査読有り, 招待無し
筆頭著者, 責任著者 - Haploinsufficiency in the PPARα and LDL receptor genes leads to gender- and age-specific obesity and hyperinsulinemia.
SUGIYAMA Eiko; SUGIYAMA Eiko; TANAKA Naoki; NAKAJIMA Tamie; KAMIJO Yuji; YOKOYAMA Shin; LI Yufeng; GONZALEZ Frank J; AOYAMA Toshifumi
Biochem Bioph Res Co, 350(2), 370-376, 2006年, 査読有り, 招待無し - Acute colorectal obstruction treated by means of transanal drainage tube: effectiveness before surgery and stenting.
Akira Horiuchi; Yoshiko Nakayama; Naoki Tanaka; Masashi Kajiyama; Hideyasu Fujii; Takahide Yokoyama; Ken Hayashi
The American journal of gastroenterology, 100(12), 2765-70, 2005年12月, 査読有り - Suppression of expression of muscle-associated proteins by PPARalpha in brown adipose tissue.
Yuhong Tong; Atsushi Hara; Makiko Komatsu; Naoki Tanaka; Yuji Kamijo; Frank J Gonzalez; Toshifumi Aoyama
Biochemical and biophysical research communications, 336(1), 76-83, 2005年10月, 査読有り - Usefulness of a small-caliber, variable-stiffness colonoscope as a backup in patients with difficult or incomplete colonoscopy.
Akira Horiuchi; Yoshiko Nakayama; Masashi Kajiyama; Hideyasu Fujii; Naoki Tanaka
The American journal of gastroenterology, 99(10), 1936-40, 2004年10月, 査読有り
最終著者 - Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage
T Nakajima; Y Kamijo; N Tanaka; E Sugiyama; E Tanaka; K Kiyosawa; Y Fukushima; JM Peters; FJ Gonzalez; T Aoyama
HEPATOLOGY, 40(4), 972-980, 2004年10月, 査読有り, 招待無し
責任著者 - Phlebotomy: a promising treatment for chronic hepatitis C
N Tanaka; K Kiyosawa
JOURNAL OF GASTROENTEROLOGY, 39(6), 601-603, 2004年06月, 査読有り, 招待無し
筆頭著者, 責任著者 - Ribavirin-induced pure red-cell aplasia during treatment of chronic hepatitis C.
Naoki Tanaka; Fumihiro Ishida; Eiji Tanaka
The New England journal of medicine, 350(12), 1264-5, 2004年03月, 査読有り
筆頭著者 - In vivo stabilization of nuclear retinoid X receptor alpha in the presence of peroxisome proliferator-activated receptor alpha
N Tanaka; K Hora; H Makishima; Y Kamijo; K Kiyosawa; FJ Gonzalez; T Aoyama
FEBS LETTERS, 543(1-3), 120-124, 2003年05月, 査読有り, 招待無し
筆頭著者 - Development of hepatocellular carcinoma after longterm sustained complete response to interferon therapy: what is the mechanism?
Tanaka, N; Kiyosawa, K
JOURNAL OF GASTROENTEROLOGY, 38(4), 417-419, 2003年04月, 査読有り, 招待無し
筆頭著者, 責任著者 - 非アルコール性脂肪性肝炎
田中 直樹; 清澤 研道
肝臓, 43(12), 539-549, 2002年12月, 査読有り, 招待無し - A case of nephrotic syndrome due to lupus nephritis which was controlled with low-density lipoprotein apheresis.
Yuji Kamijo; Yoko Kaneko; Toru Ichikawa; Nobuhiko Kobayashi; Takayuki Koyama; Tetsuji Kakegawa; Hiroshi Kamijo; Keiichi Kono; Satoshi Minami; Naoki Tanaka; Hideo Arakura; Masayuki Hirata; Makoto Higuchi; Kendo Kiyosawa; Kazuhiko Hora
Therapeutic apheresis : official journal of the International Society for Apheresis and the Japanese Society for Apheresis, 6(6), 459-62, 2002年12月, 査読有り - 非アルコール性脂肪肝炎の発症機構とPPAR
田中 直樹; 青山 俊文
日本消化器病學會雜誌 = The Japanese journal of gastro-enterology, 99(6), 563-569, 2002年06月, 査読有り, 招待無し - Identification of functions of peroxisome proliferator-activated receptor α in proximal tubules.
KAMIJO Y; HORA K; TANAKA N; USUDA N; KIYOSAWA K; NAKAJIMA T; GONZALEZ Fj; AOYAMA T
J Am Soc Nephrol, 13(7), 1691-1702, 2002年, 査読有り, 招待無し - トピックス 4.Peroxisome proliferator-activated receptor(PPAR)
田中 直樹; 青山 俊文
日本内科学会雑誌, 90(10), 2033-2039, 2001年10月, 査読有り, 招待無し
筆頭著者 - Initiation of enzyme replacement therapy for an adult patient with asymptomatic type 1 Gaucher's disease
Tanaka, N; Saito, H; Ito, T; Momose, K; Ishida, F; Hora, K; Kiyosawa, K; Ida, H
INTERNAL MEDICINE, 40(8), 716-721, 2001年08月, 査読有り, 招待無し
筆頭著者, 責任著者 - Age-dependent obesity and hyperinsulinemia in PPARα(+/–) LDLR(+/–) male mice.
Sugiyama E; Tanaka N; Nakajima T; Kamijo Y; Aoyama T
J Diabetes Complicat, 16, 51-56, 2001年, 招待無し - 脂肪肝とPPARα
青山俊文; 中島民江; 田中直樹
肝臓病学の進歩, 27(9), 1-7, 2001年, 査読有り, 招待無し - Back pain out of the blue in a haemodialysis patient
Tanaka, N; Kasahara, H; Yoshie, T; Hora, K; Kiyosawa, K
NEPHROLOGY DIALYSIS TRANSPLANTATION, 14(7), 1792-1794, 1999年07月, 査読有り, 招待無し
筆頭著者, 責任著者
MISC
- 【PPARα revisit】 PPARαと疾患 NASHとPPARα
田中 直樹; 木村 岳史; 長屋 匡信; 小松 通治; 青山 俊文
The Lipid, 27(4), 336-342, 2016年10月 - Toll-like receptor 4とMyD 88がNAFLDの線維化に関連する
小松 通治; 田中 直樹; 長屋 匡信; 市川 雪; 木村 岳史; 森田 進; 城下 智; 梅村 武司; 松本 晶博; 田中 榮司
肝臓, 53(Suppl.1), A482-A482, 2012年04月 - 【NASH/NAFLDのUp to Date】 NASH/NAFLDの分子病態メカニズム Burned-out NASHの形成機構 肝細胞内の脂肪代謝関連遺伝子解析について
小松 通治; 長屋 匡信; 田中 直樹; 田中 榮司
肝・胆・膵, 60(6), 941-946, 2010年06月 - 中学生における非アルコール性脂肪肝疾患(NAFLD)の頻度と生活習慣の検討
小松 通治; 田中 直樹; 長屋 匡信; 田中 榮司
肝臓, 51(Suppl.1), A388-A388, 2010年04月 - 膵・胆道疾患における消化吸収障害とその対策 膵頭十二指腸切除術後のNAFLD・その臨床像と発症機構
長屋 匡信; 田中 直樹; 田中 榮司
日本消化器病学会雑誌, 106(臨増大会), A723-A723, 2009年09月 - C型慢性肝炎1b型高ウイルス量患者に対するペグインターフェロンとリバビリン併用療法の治療効果に与える宿主およびウイルス因子の影響
松本 晶博; 白川 晴章; 米沢 傑; 上條 敦; 長屋 匡信; 城下 智; 小松 通治; 田中 直樹; 梅村 武司; 一條 哲也; 吉澤 要; 太田 正穂; 勝山 善彦; 清澤 研道; 田中 榮司
肝臓, 50(Suppl.1), A131-A131, 2009年04月 - 原発性胆汁性肝硬変患者におけるゲノムワイドマイクロサテライト解析の検討
城下 智; 梅村 武司; 吉澤 要; 一條 哲也; 米田 傑; 上條 敦; 長屋 匡信; 小松 通治; 田中 直樹; 松本 晶博; 田中 榮司
肝臓, 50(Suppl.1), A162-A162, 2009年04月 - NASHでは線維化進行に伴いなぜ肝脂肪沈着が減少するのか 肝生検組織を用いた脂質代謝関連分子の発現解析
長屋 匡信; 田中 直樹; 上條 敦; 城下 智; 小松 通治; 梅村 武司; 一條 哲也; 松本 晶博; 吉澤 要; 田中 榮司
肝臓, 50(Suppl.1), A211-A211, 2009年04月 - 血中サイトケラチン18値はNAFLD histological activity scoreを反映する有用なバイオマーカーである
田中 直樹; 小松 通治; 長屋 匡信; 田中 榮司
肝臓, 50(Suppl.1), A324-A324, 2009年04月 - C型慢性肝炎に対するペグインターフェロンα-2a+リバビリン併用療法の有効性・安全性に関する再治療例を含めた検討
松本 晶博; 宜保 行雄; 米田 傑; 上條 敦; 長屋 匡信; 城下 智; 小松 通治; 田中 直樹; 梅村 武司; 一條 哲也; 吉澤 要; 田中 榮司
肝臓, 50(Suppl.1), A349-A349, 2009年04月 - HCVはインスリン抵抗性を惹起するか 無症候性キャリアでの検討
田中 直樹; 長屋 匡信; 田中 榮司
肝臓, 49(Suppl.1), A215-A215, 2008年04月 - 肥満を伴わない非アルコール性脂肪肝疾患
田中 直樹; 小松 通治; 白川 晴章; 長屋 匡信; 城下 智; 小林 倫子; 新井 薫; 梅村 武司; 一條 哲也; 松本 晶博; 吉澤 要; 田中 榮司
長野県医学会雑誌, 38, 65-65, 2008年03月
共同研究・競争的資金等の研究課題
- 腎のPPARα機能・脂肪酸代謝の低下が腎臓病と全身臓器に及ぼす影響の解析
科学研究費助成事業, 日本学術振興会, 基盤研究(C)
信州大学
2025年04月01日 - 2029年03月31日 - Autophagy-脂肪酸代謝クロストーク変調が腎障害に及ぼす影響についての解析
科学研究費助成事業, 日本学術振興会, 基盤研究(C)
信州大学
2022年04月01日 - 2025年03月31日 - 脳特異的脂質に着目した新たな脳内老化機構の解明と予防法の開発
科学研究費助成事業, 日本学術振興会, 基盤研究(C)
信州大学
2021年04月01日 - 2024年03月31日 - 食事中トランス脂肪酸による肝発癌促進機能の解明と予防法の開発
科学研究費補助金（基盤研究（Ｃ））, 基盤研究（Ｃ）
2019年 - 2021年 - トランス脂肪酸毒性によるC型肝炎関連肝癌増悪機構の解明と予防法の開発
科学研究費助成事業, 日本学術振興会, 基盤研究(C)
信州大学
2016年04月01日 - 2019年03月31日 - 生体異物代謝を機軸とした非アルコール性脂肪肝炎発症機構の解明
科学研究費補助金（基盤研究（Ｃ））, 基盤研究（Ｃ）
2016年 - 2018年 - 硫酸化糖脂質の生成・排泄促進による新たな酸化ストレス抑制作用の解明
科学研究費助成事業, 日本学術振興会, 基盤研究(C)
信州大学
2015年04月01日 - 2018年03月31日 - PPARα 活性化抑制を標的としたＣ型肝炎関連肝癌の予防法の開発
科学研究費補助金（若手研究（Ｂ））, 若手研究（Ｂ）
2009年 - 2010年 - 消化管および肝臓におけるアルコール依存的炎症性障害の分子機構の解明と予防法の開発
科学研究費助成事業, 日本学術振興会, 基盤研究(C)
信州大学
2007年 - 2008年 - PPARα ノックアウトマウスを用いたアルコール性肝障害の病態解析と治療法の開発
科学研究費補助金（若手研究（Ｂ））, 若手研究（Ｂ）
2007年 - 2008年 - 共同研究, 米国国立衛生研究所 癌研究所 代謝部門
2004年 - 国際医学研究・教育
- 脂肪肝・肝炎から肝発癌機構
- 肥満や脂肪肝を予防する機能性食品
- ＰＰＡＲａノックアウトマウスを用いたアルコール性肝障害の病態解析と治療法の開発
科学研究費補助金（若手研究（Ｂ）） - 栄養素と消化器病
- 肝臓と脂肪細胞の相互関係
- 脂質代謝と核内受容体
- HCVコア蛋白による肝発癌機構
- 非アルコール性脂肪肝炎の病態解析と治療法の開発
- メタボロミクス
社会貢献活動
メディア報道
教育活動実績
社会活動実績
