Ph.D., Osaka Prefecture University

Food sciences, Nutritional biochemistry

Food sciences, molecular nutrition

Food sciences, functional food science

2019 - 2024
Shinshu University, Faculty of Agriculture, Assistant Professor

2010 - 2013, Osaka Prefecture University, Graduate School of Life and Environmental Scienves, Environmental Sciences and Technology

2008 - 2010, Osaka Prefecture University, Graduate School of Life and Environmental Sciences, Environmental Sciences and Technology

2024
参与, Japan Society of Nutrition and Food Science, Chubu

2023
日本農芸化学会中部支部, 日本農芸化学会中部支部奨励賞（学術奨励賞）
カカオ豆抽出物が脂肪細胞の褐色化を誘導する分子機構の解析, Japan society
指導学生

Cocoa extract induces browning of white adipocytes and improves glucose intolerance in mice fed a high-fat diet.
Yonemoto E, Ihara R, Tanaka E, Mitani T.
Bioscience, Biotechnology, and Biochemistry, 88(10), 1188-1098, 20 Sep. 2024, Refereed
Last, Corresponding

BTB and CNC homology 1 deficiency disrupts intestinal IgA secretion through regulation of polymeric immunoglobulin receptor expression
Hamada R, Yonezawa A, Matsumoto K, Mitani T, Takagi T, Muto A, Igarashi K, Naito Y, Higashimura Y.
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2024, Refereed, Not invited

Genistein enhances NAD+ biosynthesis by upregulating nicotinamide phosphoribosyltransferase in adipocytes  
Watanabe S, Haruyama R, Umezawa K, Tomioka I, Nakamura S, Katayama S, Mitani T (corresponding author).
Journal of Nutirtional Biochemistry, 121, 109433, 28 Aug. 2023, Refereed
Last, Corresponding

Anti-nucleolin aptamer, iSN04, inhibits the inflammatory responses in C2C12 myoblasts by modulating the β-catenin/NF-κB signaling pathway.
Yamamoto M, Miyoshi M, Morioka K, Mitani T, Takaya T.
Biochemical and Biophysical Research Communications, 664, 1-8, 05 Jul. 2023, Refereed

25-Hydroxyvitamin D increases insulin-stimulated glucose uptake by enhancing adipocyte differentiation
Nakashima M, Mitani T (corresponding author).
Journal of Nutritional Science and Vitaminology, 68(5), 420-428, Oct. 2022, Refereed
Last, Corresponding

Isolation, identification, and in vivo evaluation of the novel antihypertensive peptide, VSKRLNGDA, derived from chicken blood cells
Wongngama W, Roytrakulb S, Mitani T, Katayama S, Nakamura S, Yongsawatdigula J.
Process Biochemistry, 115, 169-177, 15 Feb. 2022, Refereed

Genistein regulates adipogenesis by blocking the function of adenine nucleotide translocase-2 in the mitochondria.
Ikeda T, Watanabe S, Mitani T (corresponding author).
Bioscience, Biotechnology, and Biochemistry,, 29 Nov. 2021, Refereed
Last, Corresponding

Theobromine enhances the conversion of white adipocytes into beige adipocytes in a PPARgamma activation-dependent manner
Tanaka E, Mitani T (corresponding author), Nakashima M, Yonemoto E, Fujii H, Ashida H.
The Journal of Nutritional Biochemistry, 100, 108898, 05 Nov. 2021, Refereed
Corresponding

Production and characterization of chicken blood hydrolysate with antihypertensive properties
Wongngam W, Mitani T, Katayama S, Nakamura S, Yongsawatdigul J.
Poultry Science, 99(10), 5163-5174, 27 Jul. 2020, Refereed

Enzymatically synthesized glycogen prevents UVB-induced cell damage in normal human epidermal keratinocytes
Yoshioka Y, Kitakaze T, Mitani T, Furuyashiki T, Ashida H.
Journal of Clinical Biochemistry and Nutrition, 67(1), 36-42, 05 May 2020, Refereed

Intracellular cAMP contents regulate NAMPT expression via induction of C/EBPβ in adipocytes
Mitani T, Watanabe S, Wada K, Fujii H, Nakamura S, Katayama S
Biochemical and biophysical research communications, 522(3), 770-775, 30 Nov. 2019, Refereed
Lead

Oral immunotherapy with a phosphorylated hypoallergenic allergen ameliorates allergic responses more effectively than intact allergen in a murine model of buckwheat allergy.
Katayama S, Yamaguchi D, Suzuki Y, Athamneh AMA, Mitani T, Satoh R, Teshima R, Mine Y, Nakamura S.
Molecular Nutrition & Food Research, 62(21), e1800303, 14 Sep. 2018, Refereed

Soybean-derived glycine-arginine dipeptide administration promotes neurotrophic factor expression in the mouse brain
Shimizu A, Mitani T, Tanaka S, Fujii H, Maebuchi M, Amiya Y, Tanaka M, Matsui T, Nakamura S, Katayama S.
Journal of Agricultural and Food Chemistry, 66(30), 7935-7941, 01 Aug. 2018, Refereed

Long-term diet supplementation with lactobacillus paracasei K71 prevents age-related cognitive decline in senescence-accelerated mouse prone 8.
Corpuz HM, Ichikawa S, Arimura M, Mihara T, Kumagai T, Mitani T, Nakamura S, Katayama S.
Nutrients, 10(6), E762, 13 Jun. 2018, Refereed

Theophylline suppresses interleukin-6 expression by inhibiting glucocorticoid receptor signaling in pre-adipocytes
Mitani T, Takaya T, Harada N, Katayama S, Yamaji R, Nakamura S, Ashida H
Archives of Biochemistry and Biophysics, 646, 98-106, 15 May 2018, Refereed
Lead

Methylxanthine derivative-rich cacao extract suppresses differentiation of adipocytes through down-regulation of PPARγ and C/EBPs
Yamashita Y*, Mitani T*, Wang L, Ashida H.　(*Co-first Author)
Journal of Nutritional Science and Vitaminology, 64(2), 151-160, 30 Apr. 2018, Refereed
Lead

Cyperenoic acid suppresses osteoclast differentiation and delays bone loss in a senile osteoporosis mouse model by inhibiting non-canonical NF-κB pathway.
Chawalitpong S, Chokchaisiri R, Suksamrarn A, Katayama S, Mitani T, Nakamura S, Athamneh AA, Ritprajak P, Leelahavanichkul A, Aeimlapa R, Charoenphandhu N, Palaga T.
SCIENTIFIC REPORTS, 8(1), 5625, 04 Apr. 2018, Refereed

Rutinosylated ferulic acid attenuates food allergic response and colitis by up-regulating regulatory T cells in mouse models.
Katayama S, Ohno F, Mitani T, Akiyama H, Nakamura S.
Journal of Agricultural and Food Chemistry, 65(49), 10730-10737, 13 Dec. 2017, Refereed

Caffeine-stimulated intestinal epithelial cells suppress lipid accumulation in adipocytes
Mitani T, Nagano T, Harada K, Yamashita Y, Ashida H
Journal of Nutritional Science and Vitaminology, 63(5), 333-340, 08 Dec. 2017, Refereed
Lead

Theobromine suppresses adipogenesis through enhancement of CCAAT-enhancer-binding protein degradation by adenosine receptor A1
Mitani T, Watanabe S, Yoshioka Y, Katayama S, Nakamura S, Ashida H
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1864(12), 2438-2448, 28 Sep. 2017, Refereed
Lead

Solventless extraction methods for immature fruits: Evaluation of their antioxidant and cytoprotective activities
Heng MY, Katayama S, Mitani T, Ong ES, Nakamura S.
Food Chemistry, 221, 1388-1393, 15 Apr. 2017, Refereed

Role of phosphate groups on antiviral activity of casein phosphopeptide against feline calicivirus as a surrogate for norovirus.
Lebetwa N, Mitani T, Nakamura S, Katayama S
Journal of the Science of Food and Agriculture, 97(6), 1939-1944, 01 Apr. 2017, Refereed

Enzymatically synthesized glycogen inhibits colitis through decreasing oxidative stress.
Mitani T, Yoshioka Y, Furuyashiki T, Yamashita Y, Shirai Y, Ashida H.
FREE RADICAL BIOLOGY AND MEDICINE, 106, 355-367, 28 Feb. 2017, Refereed
Lead

Black soybean seed coat polyphenols prevent AAPH-induced oxidative DNA-damage in HepG2 cells
Yoshioka Y, Li X, Zhang T, Mitani T, Yasuda M, Nanba F, Toda T, Yamashita Y, Ashida H.
Journal of Clinical Biochemistry and Nutrition, 60(2), 108-114, 06 Dec. 2016, Refereed

Castration influences intestinal microflora and induces abdominal obesity in high-fat diet-fed mice.
Harada N, Hanaoka R, Horiuchi H, Kitakaze T, Mitani T, Inui H, Yamaji R.
SCIENTIFIC REPORTS, 6, 23001, 10 Mar. 2016, Refereed

Autophagic degradation of the androgen receptor mediated by increased phosphorylation of p62 suppresses apoptosis in hypoxia
Mitani T, Minami M, Harada N, Ashida H, Yamaji R.
Cellular Signalling, 27(10), 1994-2001, Oct. 2015, Refereed
Lead

Luteolin suppresses TCDD-induced wasting syndrome in a cultured adipocyte model
Ashida H, Harada K, Mishima S, Mitani T, Yamashita Y, Matsumura F.
Pesticide Biochemistry and Physiology, 120, 14-20, May 2015, Refereed

Resveratrol inhibits hypoxia-inducible factor-1α-mediated androgen receptor signaling and represses tumor progression in castration-resistant prostate cancer
Mitani T, Harada N, Tanimori S, Nakano Y, Inui H, Yamaji R.
Journal of Nutritional Science and Vitaminology, 60(4), 276-282, Aug. 2014, Refereed
Lead

Resveratrol reduces the hypoxia-induced resistance to doxorubicin in breast cancer cells
Mitani T, Ito Y, Harada N, Nakano Y, Inui H, Ashida H, Yamaji R.
Journal of Nutritional Science and Vitaminology, 60(2), 122-128, Apr. 2014, Refereed
Lead

Identification of carbonyl reductase 1 as a resveratrol-binding protein by affinity chromatography using 4 '-amino-3,5-dihydroxy-trans-stilbene
Ito Y*, Mitani T*, Harada N, Isayama A, Tanimori S, Takenaka S, Nakano Y, Inui H, Yamaji R.　(*Co-first Author)
Journal of Nutritional Science and Vitaminology, 59(4), 358-364, Aug. 2013, Refereed
Lead

Coordinated action of hypoxia-inducible factor-1 alpha and beta-catenin in androgen receptor signaling
Mitani T, Harada N, Nakano Y, Inui H, Yamaji R.
JOURNAL OF BIOLOGICAL CHEMISTRY, 287(40), 33594-33606, 28 Sep. 2012, Refereed
Lead

Kelch-like 20 up-regulates the expression of hypoxia-inducible factor-2 alpha through hypoxia- and von Hippel-Lindau tumor suppressor protein-independent regulatory mechanisms
Higashimura Y, Terai T, Yamaji R, Mitani T, Ogawa M, Harada N, Inui H, Nakano Y.
Biochemical and biophysical research communications, 413(2), 201-205, 23 Sep. 2011, Refereed

Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-1 alpha in a low androgen environment
Mitani T, Yamaji R, Higashimura Y, Harada N, Nakano Y, Inui H.
Journal of Steroid Biochemistry and Molecular Biology, 123(1-2), 58-64, Jan. 2011, Refereed
Lead

A yeast bioassay for androgenic and anti-androgenic compounds based on the NH2- and COOH-terminal interaction of androgen receptor
Ogawa M, Yamaji R, Mitani T, Murata Y, Nakao M, Harada N, Nakano Y, Inui H,
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 74(9), 1965-1968, Sep. 2010, Refereed

Involvement of three glutamine tracts in human androgen receptor transactivation
Harada N, Mitani T, Higashimura Y, Yamaji R, Okamoto K, Nakano Y, Inui H.
Journal of Steroid Biochemistry and Molecular Biology, 118(1-2), 77-84, Jan. 2010, Refereed

Anti-obesity Effect of Food Factors Based on Target Proteins: Novel Molecular Function of Methylxanthines
Mitani Takakazu
化学と生物「解説」, 60(11), 586 - 593, 2022, Refereed, Invited
Lead, Corresponding

肝臓のミトコンドリア活性化に及ぼす大豆イソフラボンの効果とその分子機構に関する研究
三谷塁一
21, 173 - 179, 01 Jun. 2019
Lead, Last, Corresponding

多機能性を持つMoonlighting Proteins (特集 タンパク質・酵素の隠された機能について,探索とその技術)
原田直樹, 三谷塁一, 山地亮一
生化学, 87(3), 279 - 285, 2015, Invited

抗酸化物質としてのレスベラトロールの多機能性
三谷塁一, 原田直樹, 山地亮一
ビタミン, 86(12), 687 - 689, 25 Dec. 2012, Invited
Lead

肥満関連疾患の予防に資する食品成分とその標的分子に関する研究
三谷塁一
第78回日本栄養・食糧学会大会（奨励賞受賞講演）（福岡）, May 2024, Invited

食品成分の標的タンパク質の同定とそれに基づく機能性発現メカニズムに関する研究
三谷塁一
日本農芸化学会2024年度大会（奨励賞受賞講演）（東京）, Mar. 2024, Invited

カカオ豆抽出物が脂肪細胞の褐色化を誘導する分子機構の解析
米本 英都、三谷 塁一
2023年度日本農芸化学会 中部・関西支部合同大会（三重）, Sep. 2023, Not invited

Not invited

2021
Japanese society for Food Factors

2009
Japan Society for Bioscience, Biotechnology, and Agrochemistry

2009
The Japanese Biochemical Society

2013
The Molecular Biology Society of Japan

2012
The Japan Society of Nutirtion and Food Science

2014
The vitamin Society of Japan

Peer review
Bioscience Reports, Jan. 2022 - Dec. 2022

Peer review
Bioscience, Biotechnology, and Biochemistry, Jan. 2022 - Dec. 2022

Peer review
International Journal of Molecular Sciences, Jan. 2021 - Dec. 2021

Peer review
Molecules, Jan. 2021 - Dec. 2021

Peer review
Bioscience, Biotechnology, and Biochemistry, Jan. 2021 - Dec. 2021

Peer review
Antioxidants, Jan. 2020 - Dec. 2020

Peer review
Molecules, Jan. 2020 - Dec. 2020

Peer review
Bioscience, Biotechnology, and Biochemistry, Jan. 2020 - Dec. 2020

Peer review
Bioscience, Biotechnology, and Biochemistry, Jan. 2019 - Dec. 2019