医学博士, 大阪大学

Immunology, Immunology

Molecular biology, Molecular biology

Functional biochemistry, Biological chemistry

Cell biology, Cellular biology

2016 - Present
信州大学医学部医学科・准教授

2010 - 2016
信州大学医学部医学科・助教

2006 - 2010
La Jolla Institute for Allergy and Immunology, 研究員

2003 - 2006
独立行政法人理化学研究所 免疫アレルギー科学総合研究センター・研究員

2000 - 2003
日本学術振興会特別研究員(DC1)

1997 - 1999
科学技術振興事業団（現 科学技術振興機構）・技術員

1999 - 2003, Osaka University, Graduate School of Medicine

1995 - 1997, Kumamoto University, 大学院理学系研究科

1991 - 1995, Tottori University, Faculty of Medicine, School of Life Sciences

Adrenomedullin-RAMP2 System Modulates Inflammation and Tissue Repair in Experimental Autoimmune Uveitis Via T-Cell and M2 Macrophage Regulation.
Yorishige Matsuda; Megumu Tanaka; Yunlu Zhao; Shinji Kakihara; Ken Hoshiyama; Takayuki Sakurai; Akiko Kamiyoshi; Yuka Ichikawa-Shindo; Hisaka Kawate; Yan Zhang; Qianqian Guo; Peixuan Li; Jiake Li; Jun Duan; Marina Hayashi; Hideki Sanjo; Toshinori Murata; Takayuki Shindo
Investigative ophthalmology & visual science, 66(6), 12-12, Jun. 2025

Differential regulation of type I and II interferon signals by the transcription factor IRF-2 for the generation and function of macrophage populations in the liver.
Kazuki Yoshizawa; Yuta Yamamoto; Masaya Takamoto; Yoh-Ichi Tagawa; Yuji Soejima; Hideki Sanjo; Shinsuke Taki
International immunology, May 2025

TAK1 Governs Monocyte-Derived Macrophage Development in Acute Sterile Peritonitis.
Katsuki Iwahori; Kengo Maeda; Hideki Sanjo
International immunology, Mar. 2025

Synthetic short mRNA prevents metastasis via innate-adaptive immunity.
Hikaru Hayashi; Sayaka Seki; Takeshi Tomita; Masayoshi Kato; Norihiro Ashihara; Tokuhiro Chano; Hideki Sanjo; Miwa Kawade; Chenhui Yan; Hiroki Sakai; Hidenori Tomida; Miyuki Tanaka; Mai Iwaya; Shinsuke Taki; Yozo Nakazawa; Yuji Soejima; Yoshihito Ueno; Sachie Hiratsuka
Nature communications, 16(1), 1925-1925, Feb. 2025

Receptor activity-modifying proteins of adrenomedullin (RAMP2/3): Roles in the pathogenesis of ARDS.
Tomoki Kasahara; Megumu Tanaka; Yunlu Zhao; Akiko Kamiyoshi; Takayuki Sakurai; Yuka Ichikawa-Shindo; Hisaka Kawate; Yorishige Matsuda; Yan Zhang; Qianqian Guo; Peixuan Li; Ken Hoshiyama; Jiake Li; Naho Onishi; Marina Hayashi; Hideki Sanjo; Kumiko Ishida; Satoshi Tanaka; Mikito Kawamata; Takayuki Shindo
Peptides, 171, 171118-171118, Jan. 2024

Interferon regulatory factor-2 is required for the establishment of the gut intraepithelial T-cell compartment.
Shigeo Tokumaru; Yuta Yamamoto; Kazuki Yoshizawa; Yuji Soejima; Hideki Sanjo; Shinsuke Taki
International immunology, 35(5), 231-241, 2023

White Blood Cell Counting Device for Dairy Cattle Using Microchannel Incorporating Light Scattering
Yamaguchi, Masaki; Nakamura, Tsuyoshi; Sanjo, Hideki
SENSORS AND MATERIALS, 35(4), 1281-1292, 2023

TAK1 Limits Death Receptor Fas-Induced Proinflammatory Cell Death in Macrophages
Maeda, Kengo; Nakayama, Jun; Taki, Shinsuke; Sanjo, Hideki
Journal of Immunology, 209(6), 1173-1179, Sep. 2022

Presence of periodontitis may synergistically contribute to cancer progression via Treg and IL-6
Kajihara, Ryo; Sakai, Hironori; Han, Yibing; Amari, Kei; Kawamoto, Makiko; Hakoyama, Yusuke; Nagashio, Sachiho; Yamada, Shin-ichi; Sanjo, Hideki; Kurita, Hiroshi
SCIENTIFIC REPORTS, 12(1), 11584, 2022

Circulating T cells and resident non-T cells restrict type 2 innate lymphoid cell expansion in the small intestine.
Yuta Yamamoto; Kazuki Yoshizawa; Masaya Takamoto; Yuji Soejima; Hideki Sanjo; Shinsuke Taki
Biochemical and biophysical research communications, 618, 93-99, 2022

Adrenomedullin Ameliorates Pulmonary Fibrosis by Regulating TGF-ß-Smads Signaling and Myofibroblast Differentiation
Yangxuan Wei; Megumu Tanaka; Takayuki Sakurai; Akiko Kamiyoshi; Yuka Ichikawa-Shindo; Hisaka Kawate; Nanqi Cui; Shinji Kakihara; Yunlu Zhao; Kohsuke Aruga; Hideki Sanjo; Takayuki Shindo
Endocrinology, 162(8), Aug. 2021

Extracellular mRNA transported to the nucleus exerts translation-independent function
Takeshi Tomita; Masayoshi Kato; Taishi Mishima; Yuta Matsunaga; Hideki Sanjo; Ken-ichi Ito; Kentaro Minagawa; Toshimitsu Matsui; Hiroyuki Oikawa; Satoshi Takahashi; Toshifumi Takao; Noriki Iwai; Takashi Mino; Osamu Takeuchi; Yoshiro Maru; Sachie Hiratsuka
Nature Communications, 12(1), 2021

Generation of a common innate lymphoid cell progenitor requires interferon regulatory factor 2.
Okubo Y, Tokumaru S, Yamamoto Y, Miyagawa SI, Sanjo H, Taki S.
Int Immunol., 2019

Staphylococcal superantigen-like 12 activates murine bone marrow derived mast cells.
Kobayashi M, Kitano T, Nishiyama S, Sanjo H, Onozaki K, Taki S, Itoh S, Hida S.
Biochem Biophys Res Commun., 2019

Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death.
Hideki Sanjo; Jun Nakayama; Takahiro Yoshizawa; Hans Joerg Fehling; Shizuo Akira; Shinsuke Taki
Journal of immunology (Baltimore, Md. : 1950), 203(4), 783-788, 2019, Not invited

Water intake increases mesenteric lymph flow and the total flux of albumin, long-chain fatty acids, and IL-22 in rats: new concept of absorption in jejunum.
Sachiho Nagashio; Kumiko Ajima; Daisuke Maejima; Hideki Sanjo; Ryo Kajihara; Moyuru Hayashi; Tomomi Watanabe-Asaka; Maki Kaidoh; Yumiko Yokoyama; Shinshuke Taki; Yoshiko Kawai; Toshio Ohhashi
American journal of physiology. Gastrointestinal and liver physiology, 316(1), G155-G165, 2019, Not invited

Loss of TAK1 leads to TLR-driven macrophage cell death and inflammation that occur by a TNF-independent mechanism
Hideki Sanjo; Shinsuke Taki
CYTOKINE, 100, 78-79, Dec. 2017, Not invited

Phosphoproteomic analysis of kinase-deficient mice reveals multiple TAK1 targets in osteoclast differentiation
Eriko Sumiya; Takako Negishi-Koga; Yusuke Nagai; Ayako Suematsu; Tomomi Suda; Masahiro Shinohara; Kojiro Sato; Hideki Sanjo; Shizuo Akira; Hiroshi Takayanagi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 463(4), 1284-1290, Aug. 2015, Not invited

Conditional Deletion of TAK1 in T Cells Reveals a Pivotal Role of TCR alpha beta(+) Intraepithelial Lymphocytes in Preventing Lymphopenia-Associated Colitis
Hideki Sanjo; Shigeo Tokumaru; Shizuo Akira; Shinsuke Taki
PLOS ONE, 10(7), Jul. 2015, Not invited

Positive Feedback Within a Kinase Signaling Complex Functions as a Switch Mechanism for NF-kappa B Activation
Hisaaki Shinohara; Marcelo Behar; Kentaro Inoue; Michio Hiroshima; Tomoharu Yasuda; Takeshi Nagashima; Shuhei Kimura; Hideki Sanjo; Shiori Maeda; Noriko Yumoto; Sewon Ki; Shizuo Akira; Yasushi Sako; Alexander Hoffmann; Tomohiro Kurosaki; Mariko Okada-Hatakeyama
SCIENCE, 344(6185), 760-764, May 2014, Not invited

Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs
Daisuke Ori; Hiroki Kato; Hideki Sanjo; Sarang Tartey; Takashi Mino; Shizuo Akira; Osamu Takeuchi
JOURNAL OF IMMUNOLOGY, 190(8), 4037-4045, Apr. 2013, Not invited

Differential Requirements for IRF-2 in Generation of CD1d-Independent T Cells Bearing NK Cell Receptors
Tsuyoshi Notake; Shin Horisawa; Hideki Sanjo; Shin-ichi Miyagawa; Shigeaki Hida; Shinsuke Taki
JOURNAL OF IMMUNOLOGY, 188(10), 4838-4845, May 2012, Not invited

Essential roles of Tab2 and Tab3 1n the activation of MAPK, but not NF-kB, in B cells.
Ori D; Kato H; Sanjo H; Akira S; Takeuchi O
2012 Annual Meeting of Japanese Society for Immunology. No. 1-E 一W7-3-0/P, Kobe, December 5-7, 2012., 2012, Refereed, Not invited

Polymorphic Variants of LIGHT (TNF Superfamily-14) Alter Receptor Avidity and Bioavailability
Timothy C. Cheung; Ken Coppieters; Hideki Sanjo; Lisa M. Oborne; Paula S. Norris; Amy Coddington; Steven W. Granger; Dirk Elewaut; Carl F. Ware
JOURNAL OF IMMUNOLOGY, 185(3), 1949-1958, Aug. 2010, Not invited

Allosteric Regulation of the Ubiquitin: NIK and Ubiquitin: TRAF3 E3 Ligases by the Lymphotoxin-beta Receptor
Hideki Sanjo; Dirk M. Zajonc; Rebecca Braden; Paula S. Norris; Carl F. Ware
JOURNAL OF BIOLOGICAL CHEMISTRY, 285(22), 17148-17155, May 2010, Not invited

T Cell Intrinsic Heterodimeric Complexes between HVEM and BTLA Determine Receptivity to the Surrounding Microenvironment
Timothy C. Cheung; Lisa M. Oborne; Marcos W. Steinberg; Matthew G. Macauley; Satoshi Fukuyama; Hideki Sanjo; Claire D'Souza; Paula S. Norris; Klaus Pfeffer; Kenneth M. Murphy; Mitchell Kronenberg; Patricia G. Spear; Carl F. Ware
JOURNAL OF IMMUNOLOGY, 183(11), 7286-7296, Dec. 2009, Not invited

Unconventional ligand activation of herpesvirus entry mediator signals cell survival
Timothy C. Cheung; Marcos W. Steinberg; Lisa M. Oborne; Matthew G. Macauley; Satoshi Fukuyama; Hideki Sanjo; Claire D'Souza; Paula S. Norris; Klaus Pfeffer; Kenneth M. Murphy; Mitchell Kronenberg; Patricia G. Spear; Carl F. Ware
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106(15), 6244-6249, Apr. 2009, Not invited

Regulation of immunity through the LT beta receptor and HVEM-BTLA circuit
Carl F. Ware; Tim Cheung; Carl DeTrez; Kirsten Schneider; John Sedy; Claire Jacquin; Satoshi Fukuyama; Hideki Sanjo; Brian Greenberg
CYTOKINE, 43(3), 236-236, Sep. 2008, Not invited

Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion
Tomoharu Yasuda; Hideki Sanjo; Gilles Pages; Yohei Kawano; Hajime Karasuyama; Jacques Pouyssegur; Masato Ogata; Tomohiro Kurosaki
IMMUNITY, 28(4), 499-508, Apr. 2008, Not invited

Extracellular signal-regulated protein kinase 2 is required for efficient generation of B cells bearing antigen-specific immunoglobulin G
Hideki Sanjo; Masaki Hikida; Yuichi Aiba; Yoshiko Mori; Naoya Hatano; Masato Ogata; Tornohiro Kurosaki
MOLECULAR AND CELLULAR BIOLOGY, 27(4), 1236-1246, Feb. 2007, Not invited

TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells
Shintaro Sato; Hideki Sanjo; Tohru Tsujimura; Jun Ninomiya-Tsuji; Masahiro Yamamoto; Taro Kawai; Osamu Takeuchi; Shizuo Akira
INTERNATIONAL IMMUNOLOGY, 18(10), 1405-1411, Oct. 2006, Not invited

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling
Masahiro Yamamoto; Toru Okamoto; Kiyoshi Takeda; Shintaro Sato; Hideki Sanjo; Satoshi Uematsu; Tatsuya Saitoh; Naoki Yamamoto; Hiroaki Sakurai; Ken J. Ishii; Shoji Yamaoka; Taro Kawai; Yoshiharu Matsuura; Osamu Takeuchi; Shizuo Akira
NATURE IMMUNOLOGY, 7(9), 962-970, Sep. 2006, Not invited

TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis
Emily Omori; Kunihiro Matsumoto; Hideki Sanjo; Shintaro Sato; Shizuo Akira; Robert C. Smart; Jun Ninomiya-Tsuji
JOURNAL OF BIOLOGICAL CHEMISTRY, 281(28), 19610-19617, Jul. 2006, Not invited

TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappa B
N Uemura; T Kajino; H Sanjo; S Sato; S Akira; K Matsumoto; J Ninomiya-Tsuji
JOURNAL OF BIOLOGICAL CHEMISTRY, 281(12), 7863-7872, Mar. 2006, Not invited

BANK negatively regulates Akt activation and subsequent B cell responses
Y Aiba; T Yamazaki; T Okada; K Gotoh; H Sanjo; M Ogata; T Kurosaki
IMMUNITY, 24(3), 259-268, Mar. 2006, Not invited

Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway
P Zhu; SH Baek; EM Bourk; KA Ohgi; Garcia-Bassets, I; H Sanjo; S Akira; PF Kotol; CK Glass; MG Rosenfeld; DW Rose
CELL, 124(3), 615-629, Feb. 2006, Not invited

PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1
H Shinohara; T Yasuda; Y Aiba; H Sanjo; M Hamadate; H Watarai; H Sakurai; T Kurosaki
JOURNAL OF EXPERIMENTAL MEDICINE, 202(10), 1423-1431, Nov. 2005, Not invited

Essential function for the kinase TAK1 in innate and adaptive immune responses
S Sato; H Sanjo; K Takeda; J Ninomiya-Tsuji; M Yamamoto; T Kawai; K Matsumoto; O Takeuchi; S Akira
NATURE IMMUNOLOGY, 6(11), 1087-1095, Nov. 2005, Not invited

TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway
S Kishida; H Sanjo; S Akira; K Matsumoto; J Ninomiya-Tsuji
GENES TO CELLS, 10(5), 447-454, May 2005, Not invited

The roles of two I kappa B kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection
H Hemmi; O Takeuchi; S Sato; M Yamamoto; T Kaisho; H Sanjo; T Kawai; K Hoshino; K Takeda; S Akira
JOURNAL OF EXPERIMENTAL MEDICINE, 199(12), 1641-1650, Jun. 2004, Not invited

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
M Yamamoto; S Sato; H Hemmi; K Hoshino; T Kaisho; H Sanjo; O Takeuchi; M Sugiyama; M Okabe; K Takeda; S Akira
SCIENCE, 301(5633), 640-643, Aug. 2003, Not invited

TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling
H Sanjo; K Takeda; T Tsujimura; J Ninomiya-Tsuji; K Matsumoto; S Akira
MOLECULAR AND CELLULAR BIOLOGY, 23(4), 1231-1238, Feb. 2003, Not invited

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
M Yamamoto; S Sato; H Hemmi; H Sanjo; S Uematsu; T Kaisho; K Hoshino; O Takeuchi; M Kobayashi; T Fujita; K Takeda; S Akira
NATURE, 420(6913), 324-329, Nov. 2002, Not invited

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
H Hemmi; T Kaisho; O Takeuchi; S Sato; H Sanjo; K Hoshino; T Horiuchi; H Tomizawa; K Takeda; S Akira
NATURE IMMUNOLOGY, 3(2), 196-200, Feb. 2002, Not invited

特集 モチーフ･ドメインリスト 9.その他 DEATHドメイン
山条 秀樹; 審良 静男
生体の科学, 52(5), 521-522, Oct. 2001

A Toll-like receptor recognizes bacterial DNA
H Hemmi; O Takeuchi; T Kawai; T Kaisho; S Sato; H Sanjo; M Matsumoto; K Hoshino; H Wagner; K Takeda; S Akira
NATURE, 408(6813), 740-745, Dec. 2000, Not invited

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
O Takeuchi; K Hoshino; T Kawai; H Sanjo; H Takada; T Ogawa; K Takeda; S Akira
IMMUNITY, 11(4), 443-451, Oct. 1999, Not invited

TLR6: A novel member of an expanding Toll-like receptor family
O Takeuchi; T Kawai; H Sanjo; NG Copeland; DJ Gilbert; NA Jenkins; K Takeda; S Akira
GENE, 231(1-2), 59-65, Apr. 1999, Not invited

Limb and skin abnormalities in mice lacking IKK alpha
K Takeda; O Takeuchi; T Tsujimura; S Itami; O Adachi; T Kawai; H Sanjo; K Yoshikawa; N Terada; S Akira
SCIENCE, 284(5412), 313-316, Apr. 1999, Not invited

Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
K Hoshino; O Takeuchi; T Kawai; H Sanjo; T Ogawa; Y Takeda; K Takeda; S Akira
JOURNAL OF IMMUNOLOGY, 162(7), 3749-3752, Apr. 1999, Not invited

Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains
T Kawai; H Sanjo; S Akira
GENE, 227(2), 249-255, Feb. 1999, Not invited

A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages.
Matsumoto M; Tanaka T; Kaisho T; Sanjo H; Copeland NG; Gilbert DJ; Jenkins NA; Akira S
J Immunol, 1999

DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis
H Sanjo; T Kawai; S Akira
JOURNAL OF BIOLOGICAL CHEMISTRY, 273(44), 29066-29071, Oct. 1998, Not invited

The gene structure and promoter analysis of mouse lymphocyte signal transduction molecule alpha 4 that is related to the yeast TAP42 involved in a rapamycin-sensitive pathway
K Maeda; S Inui; H Sanjo; N Sakaguchi
GENE, 210(2), 287-295, Apr. 1998, Not invited

ZIP kinase, a novel serine/threonine kinase which mediates apoptosis
T Kawai; M Matsumoto; K Takeda; H Sanjo; S Akira
MOLECULAR AND CELLULAR BIOLOGY, 18(3), 1642-1651, Mar. 1998, Not invited

Ig receptor binding protein 1 (alpha4) is associated with a rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein phosphatase 2A.
Inui S; Sanjo H; Maeda K; Yamamoto H; Miyamoto E; Sakaguchi N
Blood, 1998

日本サイトカイン学会

日本分子生物学会

日本免疫学会

肝細胞癌局所におけるNK細胞受容体を介した細胞障害性T細胞機能制御機構の解明
科学研究費助成事業, 日本学術振興会, 基盤研究(C)
信州大学
Apr. 2024 - Mar. 2027

TNFシグナル関連分子群に着目したマクロファージの運命決定制御機構の解明
科学研究費補助金（基盤研究(C)（一般））
Apr. 2021 - Mar. 2024

家族性地中海熱（FMF）インフラマソームシグナル伝達異常をゲノム創薬で解決する開発研究
受託事業, 日本医療研究開発機構(AMED)
01 Apr. 2019

TNFシグナル関連分子群に着目したマクロファージの発生分化制御機構の解明
科学研究費補助金（基盤研究(C)）, 日本学術振興会
Apr. 2016 - Mar. 2019

Regulation of development and function of unconventional T cells and innate lymphoid cells.
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
Apr. 2015 - Mar. 2018

Positive and negative regulation of cytokine signals in basophils
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
Apr. 2012 - Mar. 2015

好塩基球のサイトカイン産生と２型免疫応答発動に関与するシグナル伝達経路の制御機構
科学研究費補助金（若手研究（B））, 日本学術振興会
Apr. 2011 - Mar. 2012

Intracellularsignals regulating cytokine production in basophils
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
Shinshu University
2009 - 2012

生体防御機構に関与するプロテインキナーゼ及び関連分子群の生理的機能の解明
科学研究費助成事業, 日本学術振興会, 特別研究員奨励費
大阪大学
2000 - 2002

炎症反応制御を構成する新規シグナルネットワークの解明
その他の資金, 公益財団法人小林国際奨学財団

新規疾患モデルマウスを用いた粘膜免疫制御機構に関する研究
その他の資金, Aibaworks

マクロファージによる組織恒常性維持機構を司るシグナルネットワークの解明
その他の資金, 公益財団法人 武田科学振興財団

腸管上皮内リンパ球による生体防御機構に関する研究
その他の資金, 公益財団法人 信州医学振興会