Microcirculation and Lymph Circulation

1997 - 2001, Hokkaido University, Graduate School, Division of Medicine

1985 - 1991, Hokkaido University, Faculty of Medicine

2004
Gordon Research Conference, The 1st molecular mechanisms in lymphatic function and disease, Young Investigator Poster Awards

2002
The 3rd International Sentinel Node Congress, Young Investigator Award

Heatstroke risk informing system using wearable perspiration ratemeter on users undergoing physical exercise. Scientific Reports
Momose H, Takasaka M, Watanabe-Asaka T, Hayashi M, Maejima D, Kawai Y, Ohhashi T
SCIENTIFIC REPORTS, 13(1), 416, 2023

Cell surface ATP synthase-released H + and ATP plays key roles in cocoa butter intake-mediated regulation of gut immunity through releases of cytokines in rat.
Arai N, Kajihara R, Takasaka M, Amari K, Kuneshita N, Maejima D, Watanabe-Asaka T, Hayashi M, Yokoyama Y, Kaidoh M, Kawai Y, Ohhasi T
Pfllug Arch Eur J Phy, 475(8), 945-960, 2023

Physiological roles of lymph flow-mediated nitric oxide in lymphatic system.
Ohhashi T, Kawai Y, Maejima D, Hayashi M, Watanabe-Asaka T
Lymphatic Res Biol, 21(3), 253-261, 2023

Estimation of the lymph flow through thoracic duct in human subjects using the urine osmolarity: applicable for evaluating the effectiveness of manual lymph drainage.
Ohhashi T, Kawai Y, Hayashi M, Watanabe-Asaka T
Lymphatic Res Biol, 20(3), 282-289, 2022

Portal blood flow-dependent NO-mediated lymph formation in rat jejunum.
Amari K, Kajihara R, Arai N, Hayashi M, Watanabe-Asaka T, Kaidoh M, Yokoyama Y, Ajima K, Maejima D, Kawai Y, Ohhashi T
Pfllug Arch Eur J Phy, 474(5), 541-551, 2022

From digestion and absorption to innate immunity and health care: water and food intake may contribute to IL-22 in ILC3-dependent mucosal immunity in the jejunum.
Watanabe-Asaka T, Hayashi M, Maejima D, Kawai Y, Ohhashi T
J Physiol Sci, 71(1), doi: 10.1186/s12576-021-00817-x, 2021, 2021

Water intake releases serotonin from enterochromaffin cells in rat jejunal villi.
Kajihara R, Amari K, Arai N, Nagashio S, Hayashi M, Watanabe-Asaka T, Kaidoh M, Yokoyama Y, Maejima D, Kawai Y, Ohhashi T
Pfllug Arch Eur J Phy, 473(6), 921-936, 2021

Water intake accelerates ATP release from myofibroblast cells in rats: ATP-mediated podoplanin-dependent control for physiological function and immunity.
Hayashi M, Watanabe-Asaka T, Nagashio S, Kaidoh M, Yokoyama Y, Maejima D, Kajihara R, Amari K, Arai N, Kawai Y, Ohhashi T
Am J Physiol Gastrointest Liver Physiol, 320(1), G54-G65, 2021

Another route of CO2 gas excretion independent of red blood cells in human lungs.
Ide S, Arai N, Morimitsu N, Momose H, Hayashi M, Watanabe-Asaka T, Ishida T, Tanaka S, Seto T, Kawai Y, Kawamata M, Ohhashi T
Pfllug Arch Eur J Phy, 473(10), 1657-1666, 2021

Evaluating Lymph Flow through the Thoracic Duct using Urine Osmolarity in Human Participants.
Hayashi M, Watanabe-Asaka T, Maejima D, Nagashio S, Kajihara R, Amari K, Yokoyama Y, Kaidoh M, Sugano M, Honda T, Kawai Y, Ohhashi T
Lymphatic Res Biol, 18(4), 351-356, 2020

Water intake increases mesenteric lymph flow and the total flux of albumin, long-chain fatty acids, and IL-22 in rats: New concept of absorption in jejunum.
Nagashio S, Ajima K, Maejima D, Sanjo H, Kajihara R, Hayashi M, Watanabe-Asaka T, Kaidoh M, Yokoyama Y, Taki S, Kawai Y, Ohhashi T
Am J Physiol Gastrointestinal and Liver Physiology, 316(G155), G165, 2019

Lymph drainage from the chylocyst induced hemodilution in an in vivo rabbit study.
Ajima K, Kawai Y, Maejima D, Suzuki S, Yano S, Hayashi M, Katsumata A, kaidoh M, Yokoyama Y, Ohhashi T
Lymphat Res Biol, 16(2), 154-159, 2018

CO2 gas exchange in lungs.
Ohhashi T, Kawai Y
Lungs and Brething, 2(3), 1, 2018

循環生理学・免疫学・腫瘍学を連携した新しいリンパ学の提唱
大橋俊夫，河合佳子
リンパ学, 38(1), 15-18, 2015

集合リンパ管壁透過性に関するリンパ管内皮細胞の機能について
河合佳子，大橋俊夫
リンパ学, 38(1), 11-14, 2015

超音波造影剤を用いたリンパ管系の可視化
河合佳子，大橋俊夫
月刊細胞, 47(13), 12-14, 2015

癌原発巣の酸性微小環境形成に及ぼす流れ刺激の効果
河合佳子，大橋俊夫
リンパ学, 38(2), 71-73, 2015

Proposed new lymphology combined with lymphatic physiology, innate immunology, and oncology(Review).
Ohhashi T, Kawai Y
J Physiol Sci., 65(1), 51-66, 2015

Abdominal respiration induces hemodilution and related reduction of blood.
Kawai Y, Ajima K, Nagai T, Yokoyama Y, Kaidoh M, Seto E, Honda T, Ohhashi T.
Lymphat Res Biol., 13(3), 202-207, 2015

In vivo support for the new concept of pulmonary blood flow-mediated CO2 gas excretion in the lungs.
Kawai Y, Ajima K, Kaidoh M, Sakaguchi M, Tanaka S, Kawamata M, Kimura H, Ohhanshi T
Am J Physiol., 308(12), L1224-L1236, 2015

Pivotal roles of lymphatic endothelial cell layers in the permeability to hydrophilic substances through collecting lymph vessel walls: Effects of inflammatory cytokines.
Kawai Y, Kaidoh M, Yokoyama Y, Ohhashi T.
Lymphat Res Biol, 12, 124-135, 2014

New Lymphology Combined with Lymphatic Physiology, Innate Immunology, and Oncology
Ohhashi, T; Kawai, Y
Journal of Blood & Lymph, 4(2), 126, 2014

Cell surface F1/FO ATP synthase contributes to interstitial flow-mediated development of the acidic microenvironment in tumor tissues.
Kawai Y, Kaidoh M, Yokoyama Y, Ohhashi T.
Am J Physiol Cell Physiol, 305, C1139-C1150, 2013

Sphingosine 1-phosphate (S1P) induces S1P2 receptor-dependent tonic contraction in murine iliac lymph vessels.
Kimizuka K, Kawai Y, Maejima D, Ajima K, Kaidoh M, Ohhashi T.
Microcirculation, 20(1), 1-16, 2013

Shear stress-mediated F1/FO ATP synthase-dependent CO2 gas excretion from human pulmonary arteriolar endothelial cells.
Kawai Y, Kaidoh M, Yokoyama Y, Ohhashi T.
J Cell Physiol, 227, 2059-2068, 2012

Current topics of immunocytochemical and biological properties of human lymphatic endothelial cells.
Kawai Y, Ohhashi T.
Ann Vasc Dis, 5, 269-274, 2012

Recent advance in lymph dynamic analysis in lymphatics and lymph nodes.
Ikomi F, Kawai Y, Ohhashi T.
Ann Vasc Dis, 5, 258-268, 2012

Pivotal roles of shear stress in the microenvironmental changes that occur within sentinel lymph nodes.
Kawai Y, Kaidoh M, Yokoyama Y, Ohhashi T.
Cancer Sci, 103(7), 1245-1252, 2012

Real-time imaging of the lymphatic channels and sentinel lymph nodes of the stomach using contrast-enhanced ultrasonography with Sonazoid in a porcine model.
Kawai Y, Ajima K, Nagai T, Kaidoh M, Ohhashi T.
Cancer Sci, 102(11), 2073-2081, 2011

Shear stress-induced ATP-mediated endothelial constitutive nitric oxide synthase expression in human lymphatic endothelial cells.
Yoshiko Kawai, Yumiko Yokoyama, Maki Kaidoh, Toshio Ohhashi
Am J Physiol, Cell Physiol, 298, C647-C655, 2010

むくみを深く知るための生理学
大橋俊夫、河合佳子
臨床看護, 36(7), 850-854, 2010

リンパ循環学から視た皮膚の美しさと健康
大橋 俊夫, 河合 佳子
日本香粧品学会誌, 34(4), 292-296, 2010

The chemokine CCL2 facilitates ICAM-1-mediated interactions of cancer cells and lymphatic endothelial cells in sentinel lymph nodes.
Kawai Y, Kaidoh M, Yokoyama Y, Sano K, Ohhashi T: The chemokine CCL2 facilitates ICAM-1-mediated interactions of cancer cells and lymphatic endothelial cells in sentinel lymph nodes.
CANCER SCIENCE, 100, 419-428, 2009

Topics of physiological and pathophysiological functions of lymphatics.
Kawai Y, Ohhashi T
Curr Mol Med, 9, 942-53, 2009

Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells.
Song H, Suehiro J, Kanki Y, Kawai Y, Inoue K, Daida H, Yano K, Ohhashi T, Oettgen P, Aird WC, Kodama T, Minami T.
J Biol Chem, 284, 29109-24, 2009

リンパ系の生理
大橋俊夫、河合佳子
Vascular Lab, 6, 422-426, 2009

リンパ系の病理
大橋俊夫、河合佳子
Vascular Lab, 6, 533-536, 2009

Significance of tumor-associated stroma in promotion of intratumoral lymphangiogenesis: pivotal role of a hyaluronan-rich tumor microenvironment.
Koyama H, Kobayashi N, Harada M, Takeoka M, Kawai Y, Sano K, Fujimori M, Amano J, Ohhashi T, Kannagi R, Kimata K, Taniguchi S, Itano N
Am J Pathol, 172, 179-193, 2008

Heterogeneity in immunohistochemical, genomic, and biological properties of human lymphatic endothelial cells between initial and collecting lymph vessels.
Kawai Y, Hosaka K, Kaidoh M, Minami T, Kodama T, Ohhashi T
Lymphat Res Biol, 6, 15-27, 2008

Critical roles of VEGF-C-VEGF receptor 3 in reconnection of the collecting lymph vessels inmice.
Ikomi F, Kawai Y, Nakayama J, Ogiwara N, Sasaki K, Mizuno R, Ohhashi T
Microcirculation, 15, 591-603, 2008

MDA-MB-231 produces ATP-mediated ICAM-1-dependent facilitation of the attachment of carcinoma cells to human lymphatic endothelial cells.
Kawai Y, Kaidoh M, Ohhashi T
AJP Cell Physiol, 295, C1123-1132, 2008

培養リンパ管内皮細胞の最近の進歩
河合佳子、大橋俊夫
脈管学, 49, 125-130, 2008

リンパ管とリンパ管内皮細胞の形態、機能、生物学的特性
河合佳子、大橋俊夫
実験医学, 26, 849-854, 2008

Immunohistochemical demonstration of proliferating lymphatic vessels in colorectal carcinoma and its clinicopathological significance.
Omachi T, Kawai Y, Mizuno R, Nomiyama T, Miyagawa S, Ohhashi T, Nakayama J.
Cancer Letters, 246, 167-72, 2007

Characterization and microarray analysis of genes in human lymphatic endothelial cells from patients with breast cancer.
Kawai Y, Minami T, Fujimori M, Hosaka K, Mizuno R, Ikomi F, Kodama T, Ohhashi T
Lymphat Res Biol, 5, 115-126, 2007

機能的視点からみたリンパ行性癌転移の診断と制御－リンパ催行性DDSの開発を中心に－
伊古美文隆、永井崇、鈴木滋、水野理介、小野伸幸、河合佳子、大橋俊夫
リンパ学, 30, 13-16, 2007

Characterization and lymphangiogenic properties of cultured rat lymphatic endothelial cells
Kawai Y, Mizuno R, Ikomi F, Ohhashi T
Microcirculation annual, 31, 77-78, 2005

リンパ浮腫とリンパ管の機能的構築
大橋俊夫，伊古美文隆，水野理介，河合佳子
Heart View, 9, 1267-1272, 2005

リンパ行性癌転移とリンパ管の生理学
伊古美文隆，水野理介，河合佳子，大橋俊夫
細胞, 37, 192-195, 2005

リンパ系の機能と疾患
水野理介，伊古美文隆，河合佳子，大橋俊夫
炎症と免疫, 13, 395-404, 2005

ラットリンパ管内皮細胞培養株の採取部位別生物学的特徴とリンパ管新生に関する検討
河合佳子，水野理介，横山由美子，遠藤満美子，伊古美文隆，大橋俊夫
リンパ学, 28, 74-76, 2005

Culture of rat lymphatic endothelial cells isolated from afferent and efferent lymph vessels and their biological properties
Kawai, Y; Mizuno, R; Ikomi, F; Ohhashi, T
FASEB JOURNAL, 19(4), A168-A168, 2005

Current topics of physiology and pharmacology in the lymphatic system
Ohhashi T, Mizuno R, Ikomi F, Kawai Y
Pharmacol Ther, 105(2), 165-188, 2005

Development of rat lymphatic endothelial cell line and its biological properties
Kawai Y, Ohhashi T
Microcirculation Annual 2004, 20, 9-10, 2004

リンパ系の生理学から見たsentinel node理論
伊古美文隆，水野理介，河合佳子，大橋俊夫
臨床外科, 59, 535-543, 2004

静脈性血管奇形に対する硬化療法(エタノール)
佐々木　了，山本有平，河合佳子，村尾尚規，浅野剛，杉原平樹
血管腫・血管奇形の診断と治療のストラテジー, 122-129, 2004

ラットリンパ管内皮細胞を用いたリンパ管新生に関する検討
河合佳子，伊古美文隆，水野理介，大橋俊夫
リンパ学, 27, 92-96, 2004

Epigenetic silencing of E- and P-cadherin gene expression in human melanoma cell lines
Tsutsumida A, Hamada J, Tada M, Aoyama T, Furuuchi K, Kawai Y, Yamamoto Y, Sugihara T, Moriuchi T
Int J Oncol, 25(5), 1415-1421, 2004

ヒトリンパ管からのリンパ内皮細胞の直接的分離およびその培養法の開発
河合佳子，竹田明彦，Gershenwald JE，杉原平樹
医学のあゆみ, 206, 467-468, 2003

培養ヒトリンパ内皮細胞の増殖能
河合佳子，竹田明彦，Gershenwald JE
医学のあゆみ, 207, 959-960, 2003

みえる人体　構造・機能・病態　The human body book “Lymph and immunity” 訳 監訳
河合佳子、大橋俊夫
2009

朝倉書店
大橋俊夫、河合佳子, 3.Mリンパ管内酸素分圧
p282-284 2009

丸善株式会社
河合忠監訳、河合佳子, 実技試験攻略のための基本的臨床技能
2009

Proposed new lymphology combined with lymphatic physiology, innate immunology, and oncology: From lymph flow points of view
Kawai Y, Hayashi M, Watanabe-Asaka T, Ohhashi T
Lymphatic Forum 2019　, Jun. 2019

Physiological research of sentinel lymph node with lymph flow dynamics and its clinical application.
Kawai Y
International Sentinel Node Society Biennial Meeting (ISNS 2018), Oct. 2018