ＭＤ

Pharmacology, General pharmacology

Cardiology, Cardiovascular medicine

Neuroscience-general, Neurophysiology / General neuroscience

Physiology, General physiology

Embryonic medicine and pediatrics, Embryonic medicine and pediatrics

Clinical pharmacy, General physiology

2004
Professor, Dept. Mol. Pharamacol. Shinshu Univ. Sch. Med.

2002 - 2004
Associate Professor, Dept. Pharamacol. II, Osaka Univ. Grad. Sch. Med.

1998 - 2002
Assitant Professor, Dept. Card. Physiol., National Cardiovasc. Ctr. Res. Inst.

1994 - 1998
Assistant Professor, Dept. Pharmacol. II, Osaka Univ. Sch. Med.

1991 - 1992
兵庫病院内科医師

1990 - 1991
佐用共立病院内科医師

1989 - 1990
兵庫病院内科医師

1987 - 1989
医員

1984 - 1987
医員（研修医）

1992 - 1994, Postdoctal fellow, Dev. Of Cardiovascular Diseases, Dept. Intern. Med., Mayo Clinic

1978 - 1984, Kobe University, Faculty of Medicine, School of Medicine

代議員, 日本薬理学会

2005
第５回医科学応用研究財団助成による日本心電学会論文賞
Japan

1993
財団法人循環器学研究振興財団内田賞
Japan

Immune regulation following allogeneic iPSC-derived cardiomyocyte transplantation in non-human primates.
Shuji Chino; Hajime Ichimura; Shugo Tohyama; Hideki Kobayashi; Takashi Shiina; Hiroki Sakai; Keiichi Fukuda; Takuro Tomita; Mitsuhiko Yamada; Ayako Tateishi; Maki Ohya; Mikiko Kobayashi; Hiroyuki Kanno; Hirohito Ishigaki; Masahiro Agata; Hidekazu Takahashi; Jian Zhao; Xiao Yang; Zouhour G Omar; Ada Caruso; Yuki Tanaka; Naoko Shiba; Yuko Wada; Tatsuichiro Seto; James J H Chong; Shin Kadota; Yuji Shiba
Cardiovascular research, Nov. 2025

Development of a Novel Therapeutic for Pediatric Heart Failure Targeting Angiotensin II Receptor
Hiroyuki Kawagishi; Takero Nakajima; Risa Ramadhiani; Tsutomu Nakada; Takuro Tomita; Yasunari Kanda; Noriaki Emoto; Mitsuhiko Yamada
YAKUGAKU ZASSHI, 145(4), 275-280, Apr. 2025

New Emulsifying Oil Powder Extracted from Pacific Krill Protects against Vascular Cognitive Impairment in a Mouse Model of Cerebral Small Vessel Disease
ISHIDA Nanae; YAMADA Hidetoshi; HIROSE Masamichi; TAIRA Eiichi; YAMADA Mitsuhiko
Shinshu Med. J., 72(3), 169-182, Jun. 2024

Regeneration of Nonhuman Primate Hearts With Human Induced Pluripotent Stem Cell-Derived Cardiac Spheroids.
Hideki Kobayashi; Shugo Tohyama; Hajime Ichimura; Noburo Ohashi; Shuji Chino; Yusuke Soma; Hidenori Tani; Yuki Tanaka; Xiao Yang; Naoko Shiba; Shin Kadota; Kotaro Haga; Taijun Moriwaki; Yuika Morita-Umei; Tomohiko C Umei; Otoya Sekine; Yoshikazu Kishino; Hideaki Kanazawa; Hiroyuki Kawagishi; Mitsuhiko Yamada; Kazumasa Narita; Takafumi Naito; Tatsuichiro Seto; Koichiro Kuwahara; Yuji Shiba; Keiichi Fukuda
Circulation, Apr. 2024

Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin.
Yuki Tanaka; Shin Kadota; Jian Zhao; Hideki Kobayashi; Satomi Okano; Masaki Izumi; Yusuke Honda; Hajime Ichimura; Naoko Shiba; Takeshi Uemura; Yuko Wada; Shinichiro Chuma; Tsutomu Nakada; Shugo Tohyama; Keiichi Fukuda; Mitsuhiko Yamada; Tatsuichiro Seto; Koichiro Kuwahara; Yuji Shiba
Stem cell research & therapy, 14(1), 240-240, Sep. 2023

A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery.
Takashi Murayama; Nagomi Kurebayashi; Takuro Numaga-Tomita; Takuya Kobayashi; Satoru Okazaki; Kyosuke Yamashiro; Tsutomu Nakada; Shuichi Mori; Ryosuke Ishida; Hiroyuki Kagechika; Mitsuhiko Yamada; Takashi Sakurai
The Journal of general physiology, 154(12), Dec. 2022

Role of Cytokine Receptor gp130 in Functional Development of the Neonatal Mouse Heart
KAWAGISHI Hiroyuki; YAMADA Mitsuhiko
Shinshu Med. J., 70(6), 373-382, Dec. 2022

Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart
Hiroyuki Kawagishi; Tsutomu Nakada; Takuro Numaga-Tomita; Maite Larrañaga; Ang Guo; Long-Sheng Song; Mitsuhiko Yamada
American Journal of Physiology-Heart and Circulatory Physiology, May 2022, Refereed

NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca2+ Homeostasis.
Hideaki Inazumi; Koichiro Kuwahara; Yasuaki Nakagawa; Yoshihiro Kuwabara; Takuro Numaga-Tomita; Toshihide Kashihara; Tsutomu Nakada; Nagomi Kurebayashi; Miku Oya; Miki Nonaka; Masami Sugihara; Hideyuki Kinoshita; Kenji Moriuchi; Hiromu Yanagisawa; Toshio Nishikimi; Hirohiko Motoki; Mitsuhiko Yamada; Sachio Morimoto; Kinya Otsu; Richard M Mortensen; Kazuwa Nakao; Takeshi Kimura
Circulation research, 130(2), 234-248, Jan. 2022

小児期特有のアンジオテンシンシグナルと、その小児心不全治療への応用
山田充彦
Cardiac Practice, 32, 128-133, 2022
Lead, Last, Corresponding

Adrenomedullin-RAMP2 and -RAMP3 Systems Regulate Cardiac Homeostasis during Cardiovascular Stress.
Nanqi Cui; Takayuki Sakurai; Akiko Kamiyoshi; Yuka Ichikawa-Shindo; Hisaka Kawate; Megumu Tanaka; Masaaki Tanaka; Yangxuan Wei; Shinji Kakihara; Yunlu Zhao; Kohsuke Aruga; Hiroyuki Kawagishi; Tsutomu Nakada; Mitsuhiko Yamada; Takayuki Shindo
Endocrinology, 162(3), Mar. 2021

A novel way of modification of AT₁ angiotensin receptors to alleviate pediatric heart failure
Kawagishi Hiroyuki; Tomita-Numaga Takuro; Nakada Tsutomu; Kashihara Toshihide; Yamada Mitsuhiko
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 94, 2-S17-2, 2021

A novel way of modification of AT₁ angiotensin receptors to alleviate neonatal and infantile heart failure
Hiroyuki Kawagishi; Mitsuhiko Yamada
Folia Pharmacologica Japonica, 156(6), 351-354, 2021

β-Arrestin-Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate.
Toshihide Kashihara; Hiroyuki Kawagishi; Tsutomu Nakada; Takuro Numaga-Tomita; Shin Kadota; Elena E Wolf; Cheng-Kun Du; Yuji Shiba; Sachio Morimoto; Mitsuhiko Yamada
JACC. Basic to translational science, 5(11), 1057-1069, Nov. 2020

Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo.
Hajime Ichimura; Shin Kadota; Toshihide Kashihara; Mitsuhiko Yamada; Kuniaki Ito; Hideki Kobayashi; Yuki Tanaka; Naoko Shiba; Shinichiro Chuma; Shugo Tohyama; Tatsuichiro Seto; Kenji Okada; Koichiro Kuwahara; Yuji Shiba
Scientific reports, 10(1), 11883-11883, Jul. 2020

ラット心筋内におけるヒトES細胞由来心筋細胞の経時的変化
市村 創; 門田 真; 茅野 周治; 御子柴 透; 小松 正樹; 田中 晴城; 山本 高照; 大橋 伸朗; 福家 愛; 和田 有子; 柏原 俊英; 山田 充彦; 柴 祐司; 瀬戸 達一郎
日本心臓血管外科学会学術総会抄録集, 50回, O10-2, Mar. 2020

抑制性G蛋白サブユニットGαoの発現亢進はCa2+handlingの異常を介して心不全進展にかかわる
稲住 英明; 桑原 宏一郎; 桑原 佳宏; 中川 靖章; 木下 秀之; 錦見 俊雄; 呉林 なごみ; 山田 充彦; 柏原 俊英; 中尾 一和; 木村 剛
日本臨床分子医学会学術総会プログラム・抄録集, 56回, 47-47, Apr. 2019

Impact of chronic kidney dysfunction on serum Sulfatides and its metabolic pathway in mice
Yamada, Yosuke; Harada, Makoto; Hashimoto, Koji; Guo, Ran; Nakajima, Takero; Kashihara, Toshihide; Yamada, Mitsuhiko; Aoyama, Toshifumi; Kamijo, Yuji
GLYCOCONJUGATE JOURNAL, 36(1), 1-11, Feb. 2019

PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca²⁺ channels with full-length Ca_V1.2 C-terminus
Nakada Tsutomu; Guo Xiaoguang; Kashihara Toshihide; Aoyama Toshifumi; Yamada Mitsuhiko
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 92, 2-O-26, 2019

Prostanoid EP4 Receptor-Mediated Augmentation of I-h Currents in A beta Dorsal Root Ganglion Neurons Underlies Neuropathic Pain
Zhang, Hao; Kashihara, Toshihide; Nakada, Tsutomu; Tanaka, Satoshi; Ishida, Kumiko; Fuseya, Satoshi; Kawagishi, Hiroyuki; Kiyosawa, Kenkichi; Kawamata, Mikito; Yamada, Mitsuhiko
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 368(1), 50-58, 2019

Effects of hypertension and antihypertensive treatments on sulfatide levels in serum and its metabolism
Guo, Ran; Hu, Xiao; Yamada, Yosuke; Harada, Makoto; Nakajima, Takero; Kashihara, Toshihide; Yamada, Mitsuhiko; Aoyama, Toshifumi; Kamijo, Yuji
HYPERTENSION RESEARCH, 42(5), 598-609, Dec. 2018

心不全モデルマウスにおけるG蛋白サブユニットGαoの発現亢進はCa2+handlingの異常をきたし心収縮能低下に関与する
稲住 英明; 桑原 宏一郎; 桑原 佳宏; 中川 靖章; 木下 秀之; 錦見 俊雄; 呉林 なごみ; 山田 充彦; 中尾 一和; 木村 剛
日本内分泌学会雑誌, 94(4), 1545-1545, Dec. 2018

Increase in phospholamban content in mouse skeletal muscle after denervation
Komatsu, Masatoshi; Nakada, Tsutomu; Kawagishi, Hiroyuki; Kato, Hiroyuki; Yamada, Mitsuhiko
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 39(5-6), 163-173, Dec. 2018

Sonic hedgehog signaling regulates the mammalian cardiac regenerative response
Kawagishi H, Xiong J, Rovira II, Pan H, Yan Y, Fleischmann BK, Yamada M, Finkel T
J Mol Cell Cardiol, in press, Sep. 2018

カルシウム動態制御と筋疾患 骨格筋の正常な興奮収縮連関にはL型カルシウムチャネルとジャンクトフィリンの物理的結合が必要である
中田 勉; 柏原 俊英; 小松 雅俊; 山田 充彦
日本筋学会学術集会プログラム・抄録集, 4回, 62-62, Aug. 2018

PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length Ca(V)1.2 C-terminus
Guo, Xiaoguang; Kashihara, Toshihide; Nakada, Tsutomu; Aoyama, Toshifumi; Yamada, Mitsuhiko
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 470(6), 909-921-921, Jun. 2018, Refereed

G蛋白サブユニットGαoのCa2+handling恒常性および心収縮能維持における意義の解明
稲住 英明; 桑原 宏一郎; 桑原 佳宏; 中川 靖章; 木下 秀之; 錦見 俊雄; 呉林 なごみ; 山田 充彦; 柏原 俊英; 中尾 一和; 木村 剛
日本臨床分子医学会学術総会プログラム・抄録集, 55回, 51-51, Apr. 2018

Physical interaction of junctophilin and the Ca(V)1.1 C terminus is crucial for skeletal muscle contraction
Nakada, Tsutomu; Kashihara, Toshihide; Komatsu, Masatoshi; Kojima, Katsuhiko; Takeshita, Toshikazu; Yamada, Mitsuhiko
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 115(17), 4507-4512-4512, Apr. 2018, Refereed

Angiotensin II activates CaV1.2 Ca2+ channels through -arrestin2 and casein kinase 2 in mouse immature cardiomyocytes
Kashihara, T; Nakada, T; Kojima, K; Takeshita, T; Yamada, M
J. Physiol. (Lond.), 595(13), 4207–4225-4225, Mar. 2017

生活習慣病に対する治療戦略 循環器疾患 幼若心筋細胞におけるAT1受容体/βアレスチン2を介した新しい陽性変力反応の機序の解析
山田 充彦; 柏原 俊英; 中田 勉
応用薬理, 89(1-2), 42-42, Aug. 2015

Transplantation of adipose tissue-derived stem cells improves cardiac contractile function and electrical stability in a rat myocardial infarction model
Milan Gautam; Daiki Fujita; Kazuhiro Kimura; Hinako Ichikawa; Atsushi Izawa; Masamichi Hirose; Toshihide Kashihara; Mitsuhiko Yamada; Masafumi Takahashi; Uichi Ikeda; Yuji Shiba
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 81, 139-149, Apr. 2015

横紋筋L型Ca2+チャネルの結合膜局在機構
中田勉; 山田充彦
日本薬理学会雑誌, 144(5), 217-221, Nov. 2014

Cardiac overexpression of constitutively active Galpha q causes angiotensin II type 1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice
Matsushita, N; Kashihara, T; Shimojo, H; Suzuki, S; Nakada, T; Takeishi, Y; Mende, U; Taira, E; Yamada, M; Sanbe, A; Hirose, M
PlosOne, 9(8), e106354, Sep. 2014

TRPM4 Channels Mediate Hypertonicity-induced, Ca2+-impermeable, Non-selective Cation Currents in a Cervical Cancer Cell Line, HeLa Cells
Gomi, S.; Nakada, T.; Kashihara, T.; Ikeda, U.; Yamada, M.
Shinshu Med. J., 62(1), 33-44, Feb. 2014

beta(2)-Adrenergic and M-2-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure
Toshihide Kashihara; Masamichi Hirose; Hisashi Shimojo; Tsutomu Nakada; Simmon Gomi; Minoru Hongo; Mitsuhiko Yamada
EUROPEAN JOURNAL OF PHARMACOLOGY, 724, 122-131, Feb. 2014

Phlorizin prevents electrically-induced ventricular tachyarrhythmia during ischemia in Langendorff-perfused guinea-pig hearts
Masamichi Hirose; Toshihide Shibazaki; Tsutomu Nakada; Toshihide Kashihara; Shiharu Yano; Yoshie Okamoto; Masayuki Isaji; Naoko Matsushita; Eiichi Taira; Mitsuhiko Yamada
Biological and Pharmaceutical Bulletin, 37(7), 1168-1176, 2014

カゼインキナーゼ2による心筋型L型Ca2+チャネルの基礎活性制御の分子機構
柏原 俊英; 中田 勉; 五味 志文; 山田 充彦
心電図, 33(Suppl.4), S-148, Sep. 2013

Novel Regulation of Cardiac Metabolism and Homeostasis by the Adrenomedullin-Receptor Activity-Modifying Protein 2 System
Takahiro Yoshizawa; Takayuki Sakurai; Akiko Kamiyoshi; Yuka Ichikawa-Shindo; Hisaka Kawate; Yasuhiro Iesato; Teruhide Koyama; Ryuichi Uetake; Lei Yang; Akihiro Yamauchi; Megumu Tanaka; Yuichi Toriyama; Kyoko Igarashi; Tsutomu Nakada; Toshihide Kashihara; Mitsuhiko Yamada; Hayato Kawakami; Hiroki Nakanishi; Ryo Taguchi; Tsuyoshi Nakanishi; Hiroshi Akazawa; Takayuki Shindo
HYPERTENSION, 61(2), 341-+, Feb. 2013, Refereed

骨格筋におけるカルシウムチャネル群の結合膜局在化機構
中田 勉; Flucher Bernhard E.; 柏原 俊英; 五味 志文; 山田 充彦
日本薬理学雑誌, 141(1), 7P-7P, Jan. 2013

骨格筋芽細胞株を用いたカルシウムチャネル群の細胞内局在決定機構の解析
中田 勉; Flucher Bernhard E.; 柏原 俊英; 五味 志文; 山田 充彦
日本薬理学雑誌, 141(1), 14P-14P, Jan. 2013

Nicorandil Prevents G alpha(q)-Induced Progressive Heart Failure and Ventricular Arrhythmias in Transgenic Mice
Masamichi Hirose; Yasuchika Takeishi; Tsutomu Nakada; Hisashi Shimojo; Toshihide Kashihara; Ayako Nishio; Satoshi Suzuki; Ulrike Mende; Kiyoshi Matsumoto; Naoko Matsushita; Eiichi Taira; Fumika Sato; Mitsuhiko Yamada
PLOS ONE, 7(12), e52667, Dec. 2012

The proximal C-terminus of alpha(1C) subunits is necessary for junctional membrane targeting of cardiac L-type calcium channels
Tsutomu Nakada; Bernhard E. Flucher; Toshihide Kashihara; Xiaona Sheng; Toshihide Shibazaki; Miwa Horiuchi-Hirose; Simmon Gomi; Masamichi Hirose; Mitsuhiko Yamada
BIOCHEMICAL JOURNAL, 448, 221-231, Dec. 2012

スタウロスポリン感受性キナーゼとカゼインキナーゼ2による心室筋L型Caチャネルの基礎活性の制御
柏原 俊英; 中田 勉; 五味 志文; 山田 充彦
心電図, 32(Suppl.5), S-147, Sep. 2012

KGA-2727, a Novel Selective Inhibitor of a High-Affinity Sodium Glucose Cotransporter (SGLT1), Exhibits Antidiabetic Efficacy in Rodent Models
Toshihide Shibazaki; Masaki Tomae; Yukiko Ishikawa-Takemura; Nobuhiko Fushimi; Fumiaki Itoh; Mitsuhiko Yamada; Masayuki Isaji
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 342(2), 288-296, Aug. 2012

Two mechanistically distinct effects of dihydropyridine nifedipine on Ca(V)1.2 L-type Ca2+ channels revealed by Timothy syndrome mutation
Xiaona Sheng; Tsutomu Nakada; Motohiro Kobayashi; Toshihide Kashihara; Toshihide Shibazaki; Miwa Horiuchi-Hirose; Simmon Gomi; Masamichi Hirose; Toshifumi Aoyama; Mitsuhiko Yamada
EUROPEAN JOURNAL OF PHARMACOLOGY, 685(1-3), 15-23, Jun. 2012

Chronic receptor-mediated activation of G(i/o) proteins alters basal t-tubular and sarcolemmal L-type Ca2+ channel activity through phosphatases in heart failure
Toshihide Kashihara; Tsutomu Nakada; Hisashi Shimojo; Miwa Horiuchi-Hirose; Simmon Gomi; Toshihide Shibazaki; Xiaona Sheng; Masamichi Hirose; Minoru Hongo; Mitsuhiko Yamada
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 302(8), H1645-H1654, Apr. 2012

フロリジンの虚血誘発心室頻拍に対する抑制効果
弘瀬 雅教; 中田 勉; 柴崎 利英; 柏原 俊英; 山田 充彦
岩手医学雑誌, 63(6), 352-352, Feb. 2012

Timothy症候群点変異により明らかとなったL型Ca2+チャネル阻害薬ニフェジピンの2つの異なる作用機序
生 暁娜; 中田 勉; 小林 基弘; 柏原 俊英; 青山 俊文; 山田 充彦
日本薬理学雑誌, 139(1), 15P-15P, Jan. 2012

不全心室筋細胞のT管L型Ca2+チャネル活性低下への慢性的β2アドレナリン受容体刺激の関与
柏原 俊英; 中田 勉; 生 暁娜; 柴崎 利英; 弘瀬 雅教; 山田 充彦
日本薬理学雑誌, 138(4), 2P-2P, Oct. 2011

Diacylglycerol Kinase zeta Inhibits Ventricular Tachyarrhythmias in a Mouse Model of Heart Failure - Roles of Canonical Transient Receptor Potential (TRPC) Channels
Masamichi Hirose; Yasuchika Takeishi; Takeshi Niizeki; Tsutomu Nakada; Hisashi Shimojo; Toshihide Kashihara; Miwa Horiuchi-Hirose; Isao Kubota; Ulrike Mende; Mitsuhiko Yamada
CIRCULATION JOURNAL, 75(10), 2333-2342, Oct. 2011

Acid-Sensing Ion Channels in Blood Volume Regulation
Mitsuhiko Yamada
CIRCULATION JOURNAL, 75(4), 781-782, Apr. 2011

慢性心不全に対するニコランジルの改善作用メカニズム 心不全誘発モデルマウスを用いた検討
弘瀬 雅教; 中田 勉; 柏原 俊英; 矢野 志春; 柴崎 利英; 生 暁娜; 山田 充彦
Therapeutic Research, 32(3), 262-264, Mar. 2011

Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes
Miwa Horiuchi-Hirose; Toshihide Kashihara; Tsutomu Nakada; Nagomi Kurebayashi; Hisashi Shimojo; Toshihide Shibazaki; Xiaona Sheng; Shiharu Yano; Masamichi Hirose; Minoru Hongo; Takashi Sakurai; Tetsuji Moriizumi; Hideho Ueda; Mitsuhiko Yamada
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 300(3), H978-H988, Mar. 2011

GLT細胞を用いた心筋L型Ca2+チャネルのクラスタリング機構の解析
中田 勉; Flucher Bernhard E.; 生 暁娜; 柏原 俊英; 柴崎 利英; 山田 充彦
日本薬理学雑誌, 137(1), 13P-13P, Jan. 2011

Nicorandil ameliorates impulse conduction disturbances during ischemia in isolated arterially perfused canine atria
Masamichi Hirose; Shiharu Yano; Tsutomu Nakada; Miwa Horiuchi-Hirose; Natsuko Tsujino; Mitsuhiko Yamada
INTERNATIONAL JOURNAL OF CARDIOLOGY, 146(1), 37-43, Jan. 2011

Thrombin activates Ca2+-permeating nonselective cation channels through protein kinase C in human umbilical vein endothelial cells.
Tsujino, N; Nakada, T; Tsubouchi, K; Kobayashi, M; Kawai, Y; Yano, S; Matsunaga, T; Hirose, M; Ohmori, S; Ohhashi, T; Yamada, M
Shinshu Med. J., 59(1), 13-26, 2011

フロリジンの虚血誘発心室頻拍に対する保護効果
弘瀬 雅教; 中田 勉; 柴崎 利英; 柏原 俊英; 生 暁娜; 伊佐治 正幸; 岡本 佳恵; 山田 充彦
心電図, 30(Suppl.4), S-207, Sep. 2010

Selective alpha(1A)-Adrenoceptor Stimulation Induces Mueller's Smooth Muscle Contraction in an Isolated Canine Upper Eyelid Preparation
Shiharu Yano; Masamichi Hirose; Tsutomu Nakada; Jun Nakayama; Kiyoshi Matsuo; Mitsuhiko Yamada
CURRENT EYE RESEARCH, 35(5), 363-369, May 2010

心不全誘発モデルマウスに対するニコランジル慢性投与の効果
弘瀬 雅教; 堀内 美和; 中田 勉; 柏原 俊英; 矢野 志春; 柴崎 利英; 生 暁娜; 山田 充彦
Therapeutic Research, 31(3), 288-290, Mar. 2010

Mitochondrial ATP-sensitive K+ channels, protectors of the heart
Mitsuhiko Yamada
JOURNAL OF PHYSIOLOGY-LONDON, 588(2), 283-286, Jan. 2010

Effects of hormone-sensitive lipase disruption on cardiac energy metabolism in response to fasting and refeeding
Jinya Suzuki; Masami Ueno; Miyuki Uno; Yoshikazu Hirose; Yasuo Zenimaru; Sadao Takahashi; Jun-ichi Osuga; Shun Ishibashi; Masafumi Takahashi; Masamichi Hirose; Mitsuhiko Yamada; Fredric B. Kraemer; Isamu Miyamori
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 297(5), E1115-E1124, Nov. 2009

Diacylglycerol kinase zeta inhibits G alpha q-induced atrial remodeling in transgenic mice
Masamichi Hirose; Yasuchika Takeishi; Takeshi Niizeki; Hisashi Shimojo; Tsutomu Nakada; Isao Kubota; Jun Nakayama; Ulrike Mende; Mitsuhiko Yamada
HEART RHYTHM, 6(1), 78-84, Jan. 2009

Mechanisms of preventive effect of nicorandil on ischaemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular wedges
Masamichi Hirose; Natsuko Tsujino; Tsutomu Nakada; Shiharu Yano; Hiroshi Imamura; Mitsuhiko Yamada
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 102(6), 504-514, Jun. 2008

MCP-1 induces cardioprotection against ischaemia/reperfusion injury: role of reactive oxygen species
Hajime Morimoto; Masamichi Hirose; Masafumi Takahashi; Masanori Kawaguchi; Hirohiko Ise; Pappachan E. Kolattukudy; Mitsuhiko Yamada; Uichi Ikeda
CARDIOVASCULAR RESEARCH, 78(3), 554-562, Jun. 2008

Contribution of L-type Ca(2+) channels to early afterdepolarizations induced by I(Kr) and I(Ks) channel suppression in guinea pig ventricular myocytes
Mitsuhiko Yamada; Keisuke Ohta; Atsunori Niwa; Natsuko Tsujino; Tsutomu Nakada; Masamichi Hirose
JOURNAL OF MEMBRANE BIOLOGY, 222(3), 151-166, Apr. 2008

Mechanisms of the preventive effect of pilsicainide on atrial fibrillation originating from the pulmonary vein
Masamichi Hirose; Yosuke Ohkubo; Michitoshi Takano; Mikihisa Hamazaki; Takashi Sekido; Mitsuhiko Yamada
CIRCULATION JOURNAL, 71(11), 1805-1814, Nov. 2007

Mechanisms of the preventive effect of pilsicainide on atrial fibrillation originating from the pulmonary vein
Masamichi Hirose; Yosuke Ohkubo; Michitoshi Takano; Mikihisa Hamazaki; Takashi Sekido; Mitsuhiko Yamada
CIRCULATION JOURNAL, 71(11), 1805-1814, Nov. 2007

Characterization of a novel ATP-sensitive K ⁺ channel opener, A-251179, on urinary bladder relaxation and cystometric parameters
C. C. Shieh; M. E. Brune; S. A. Buckner; K. L. Whiteaker; E. J. Molinari; I. A. Milicic; A. C. Fabiyi; A. Daza; J. D. Brioni; W. A. Carroll; K. Matsushita; M. Yamada; Y. Kurachi; M. Gopalakrishnan
British Journal of Pharmacology, 151(4), 467-475, Jun. 2007

Mutational analysis of block and facilitation of HERG current by A class III anti-arrhythmic agent, nifekalant
Yukio Hosaka; Miki Iwata; Narutoshi Kamiya; Mitsuhiko Yamada; Kengo Kinoshita; Yoshifumi Fukunishi; Kenji Tsujimae; Hiroshi Hibino; Yoshifusa Aizawa; Atsushi Inanobe; Haruki Nakamura; Yoshihisa Kurachi
CHANNELS, 1(3), 198-208, May 2007

Sodium channel blocker, pilsicainide, prevents atrial fibrillation originating from the pulmonary veins by pulmonary vein isolation in isolated arterially-perfused canine atria
Masamichi Hirose; Mitsuhiko Yamada
CIRCULATION, 114(18), 745-745, Oct. 2006

Mechanisms of protection against ischemia-induced transmural reentry by nicorandil
Masamichi Hirose; Mitsuhiko Yamada
CIRCULATION, 114(18), 746-746, Oct. 2006

The molecular pharmacology of the ATP-sensitive K^+ channel
YAMADA Mitsuhiko
Japanese Journal of Electrocardiology, 26(1), 4-10, Jan. 2006

Effects of nicorandil on the transmural conduction slowing during ischemia in canine left ventricles
M Hirose; M Yamada
JOURNAL OF PHARMACOLOGICAL SCIENCES, 100, 116P-116P, 2006

Relationship between function and structure of ATP-sensitive K^+ (K_) channels
KURACHI Yoshihisa; YAMADA Mitsuhiko
Folia Pharmacologica Japonica, 126(5), 311-316, Nov. 2005

A functional role of the C-terminal 42 amino acids of SUR2A and SUR2B in the physiology and pharmacology of cardiovascular ATP-sensitive K+ channels
M Yamada; Y Kurachi
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 39(1), 1-6, Jul. 2005

Investigation of the block and facilitation effects by nifekalant in a HERG channel
Y Hosaka; M Yamada; M Ishii; H Hibino; Y Kurachi
FASEB JOURNAL, 19(5), A1159-A1160, Mar. 2005

Phosphatidylinositol 3,4,5-trisphosphate and Ca2+/calmodulin competitively bind to the regulators of G-protein-signalling (RGS) domain of RGS4 and reciprocally regulate its action
M Ishii; S Fujita; M Yamada; Y Hosaka; Y Kurachi
BIOCHEMICAL JOURNAL, 385, 65-73, Jan. 2005

My Mission in Pharmacology
YAMADA Mitsuhiko
SHINSHU MED J, 53(3), 129-130, 2005

Effects of K-ATP channel modulation on transmural dispersion of action potential duration in canine left ventricle
M Hirose; H Imamura; M Yamada
JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 105P-105P, 2005

Molecular cloning of the protein interacting with heart-restricted leucine-rich repeat protein, HRLRRP
T Nakane; Y Inada; M Yamada
JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 239P-239P, 2005

Investigation of the block and facilitation effects by nifekalant in a HERG channel
Y Hosaka; M Yamada; M Ishii; Y Kurachi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 97(6), 235P-235P, 2005

Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes
H Hibino; A Fujita; K Iwai; M Yamada; Y Kurachi
JOURNAL OF BIOLOGICAL CHEMISTRY, 279(42), 44065-44073, Oct. 2004

Comparison of kinetic properties of quinidine and dofetilide block of HERG channels
K Tsujimae; S Suzuki; M Yamada; Y Kurachi
EUROPEAN JOURNAL OF PHARMACOLOGY, 493(1-3), 29-40, Jun. 2004

The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels
M Yamada; Y Kurachi
MOLECULAR PHARMACOLOGY, 65(5), 1198-1207, May 2004

Mutation in nucleotide-binding domains of sulfonylurea receptor 2 evokes Na-ATP-dependent activation of ATP-sensitive K+ channels: Implication for dimerization of nucleotide-binding domains to induce channel opening.
Yamada, M; Ishii, M; Hibino, H; Kurachi, Y
Mol. Pharmacol., 66, 807-816, 2004

イオンチャネルと不整脈
山田充彦; 倉智嘉久
臨床科学, 33(3), 113-118, 2004

【薬理学のQOLへの貢献】各種臓器のATP感受性K+チャネルの構造と機能:薬物制御によるQOLの向上をめざして
中谷 晴昭; 三木 隆司; 清野 進; 山田 勝也; 稲垣 暢也; 鈴木 将; 佐藤 俊明; 山田 充彦; 松下 賢治; 倉智 嘉久; 有田 眞
日本薬理学雑誌, 122(3), 243-250, Sep. 2003

[Molecular and functional diversity of ATP-sensitive K+ channels: the pathophysiological roles and potential drug targets].
Haruaki Nakaya; Takashi Miki; Susumu Seino; Katsuya Yamada; Nobuya Inagaki; Masashi Suzuki; Toshiaki Sato; Mitsuhiko Yamada; Kenji Matsushita; Yoshihisa Kurachi; Makoto Arita
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 122(3), 243-50, Sep. 2003

Nateglinide, a D-phenylalanine derivative lacking either a sulfonylurea or benzamido moiety, specifically inhibits pancreatic beta-cell-type K-ATP channels
M Chachin; M Yamada; A Fujita; T Matsuoka; K Matsushita; Y Kurachi
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 304(3), 1025-1032, Mar. 2003

ニコランジルによるATP感受性K+チャネル活性化の分子基盤の研究
山田 充彦; 松岡 哲朗; 松下 賢治; 倉智 嘉久
Therapeutic Research, 24(2), 245-246, Feb. 2003

スルホニルウレア受容体とADPの結合はC末端により制御される
松岡 哲郎; 松下 賢治; 稲野辺 厚; 藤田 秋一; 山田 充彦; 倉智 嘉久
日本薬理学雑誌, 120(4), 31P-31P, Oct. 2002

beta-adrenergic modulation of prepulse facilitation of L-type calcium channels in rabbit ventricular myocytes
M Yamada
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 444(1-2), 89-98, May 2002

The role of muscarinic K+ channels in the negative chronotropic effect of a muscarinic agonist
M Yamada
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 300(2), 681-687, Feb. 2002

The strong inwardly rectifying background potassium channel (IK1) in cardiac myocytes is composed of Kir2.2 (IRK2): RT-PCR analysis of single cardiac myocyte mRNA.
Matsumoto S; Isomoto S; Saito H; Inanobe A; Hibino H; Chachin M; Yamada M; Horio Y; Kurachi Y
Medical Journal of Osaka University, 44(1-4), 15-23, 2001, Refereed

Tertiapin potently and selectively blocks muscarinic K⁺ channels in rabbit cardiac myocytes
Hidetsuna Kitamura; Mitsuhiro Yokoyama; Hozuka Akita; Kenji Matsushita; Yoshihisa Kurachi; Mitsuhiko Yamada
Journal of Pharmacology and Experimental Therapeutics, 293(1), 196-205, Apr. 2000

Tertiapin potently and selectively blocks muscarinic K+ channels in rabbit cardiac myocytes
H Kitamura; Y Kurachi; M Yamada
BIOPHYSICAL JOURNAL, 78(1), 173A-173A, Jan. 2000

Epinastine, a nonsedating histamine H-1 receptor antagonist, has a negligible effect on HERG channel
M Chachin; Y Katayama; M Yamada; Y Horio; T Ohmura; H Kitagawa; S Uchida; Y Kurachi
EUROPEAN JOURNAL OF PHARMACOLOGY, 374(3), 457-460, Jun. 1999

G protein regulation of potassium ion channels
M Yamada; A Inanobe; Y Kurachi
PHARMACOLOGICAL REVIEWS, 50(4), 723-757, Dec. 1998

Intracellular nucleotide-mediated gating of SUR/Kir6.0 complex potassium channels expressed in a mammalian cell line and its modification by pinacidil
E Satoh; M Yamada; C Kondo; VP Repunte; Y Horio; T Iijima; Y Kurachi
JOURNAL OF PHYSIOLOGY-LONDON, 511(3), 663-674, Sep. 1998

SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil
T Shindo; M Yamada; S Isomoto; Y Horio; Y Kurachi
BRITISH JOURNAL OF PHARMACOLOGY, 124(5), 985-991, Jul. 1998

The effects of nucleotides and potassium channel openers on the SUR2A/Kir6.2 complex K+ channel expressed in a mammalian cell line, HEK293T cells
Y Okuyama; M Yamada; C Kondo; E Satoh; S Isomoto; T Shindo; Y Horio; M Kitakaze; M Hori; Y Kurachi
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 435(5), 595-603, Apr. 1998

Identification and functional analysis of sulfonylurea receptor 1 variants in Japanese patients with NIDDM
Y Ohta; Y Tanizawa; H Inoue; T Hosaka; K Ueda; A Matsutani; VP Repunte; M Yamada; Y Kurachi; J Bryan; L Aguilar-Bryan; MA Permutt; Y Oka
DIABETES, 47(3), 476-481, Mar. 1998

Chimeras of Kir6.1 and Kir6.2 reveal structural elements involved in spontaneous opening and unitary conductance of the ATP-sensitive K+ channels
C Kondo; VP Repunte; E Satoh; M Yamada; Y Horio; Y Matsuzawa; L Pott; Y Kurachi
RECEPTORS & CHANNELS, 6(2), 129-140, 1998

Sur2 and Kcnj8 genes are tightly linked on the distal region of mouse Chromosome 6
S Isomoto; Y Horio; S Matsumoto; C Kondo; M Yamada; DJ Gilbert; NG Copeland; NA Jenkins; Y Kurachi
MAMMALIAN GENOME, 8(10), 790-791, Oct. 1997

Expression and clustered distribution of an inwardly rectifying potassium channel, K-AB-2/Kir4.1, on mammalian retinal Muller cell membrane: Their regulation by insulin and laminin signals
M Ishii; Y Horio; Y Tada; H Hibino; A Inanobe; M Ito; M Yamada; T Gotow; Y Uchiyama; Y Kurachi
JOURNAL OF NEUROSCIENCE, 17(20), 7725-7735, Oct. 1997

An ATP-dependent inwardly rectifying potassium channel, K-AB-2 (Kir4.1), in cochlear stria vascularis of inner ear: Its specific subcellular localization and correlation with the formation of endocochlear potential
H Hibino; Y Horio; A Inanobe; K Doi; M Ito; M Yamada; T Gotow; Y Uchiyama; M Kawamura; T Kubo; Y Kurachi
JOURNAL OF NEUROSCIENCE, 17(12), 4711-4721, Jun. 1997

Clustering and enhanced activity of an inwardly rectifying potassium channel, Kir4.1, by an anchoring protein, PSD-95/SAP90
Y Horio; H Hibino; A Inanobe; M Yamada; M Ishii; Y Tada; E Satoh; Y Hata; Y Takai; Y Kurachi
JOURNAL OF BIOLOGICAL CHEMISTRY, 272(20), 12885-12888, May 1997

Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel
M Yamada; S Isomoto; S Matsumoto; C Kondo; T Shindo; Y Horio; Y Kurachi
JOURNAL OF PHYSIOLOGY-LONDON, 499(3), 715-720, Mar. 1997

Cloning and functional expression of a novel isoform of ROMK inwardly rectifying ATP-dependent K+ channel, ROMK6 (Kir1.1f)
C Kondo; S Isomoto; S Matsumoto; M Yamada; Y Horio; S Yamashita; K TakemuraKameda; Y Matsuzawa; Y Kurachi
FEBS LETTERS, 399(1-2), 122-126, Dec. 1996

A functional model for G protein activation of the muscarinic K+ channel in guinea pig atrial myocytes - Spectral analysis of the effect of GTP on single-channel kinetics
Y Hosoya; M Yamada; H Ito; Y Kurachi
JOURNAL OF GENERAL PHYSIOLOGY, 108(6), 485-495, Dec. 1996

A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel
S Isomoto; C Kondo; M Yamada; S Matsumoto; O Higashiguchi; Y Horio; Y Matsuzawa; Y Kurachi
JOURNAL OF BIOLOGICAL CHEMISTRY, 271(40), 24321-24324, Oct. 1996

Specialized release zones in chromaffin cells examined with pulsed-laser imaging
IM Robinson; M Yamada; M CarrionVazquez; VA Lennon; JM Fernandez
CELL CALCIUM, 20(2), 181-201, Aug. 1996

Competition between Mg2+ and spermine for a cloned IRK2 channel expressed in a human cell line
T Yamashita; Y Horio; M Yamada; N Takahashi; C Kondo; Y Kurachi
JOURNAL OF PHYSIOLOGY-LONDON, 493(1), 143-156, May 1996

A novel ubiquitously distributed isoform of GIRK2 (GIRK2B) enhances GIRK1 expression of the G-protein-gated K+ current in Xenopus oocytes
S Isomoto; C Kondo; N Takahashi; S Matsumoto; M Yamada; T Takumi; Y Horio; Y Kurachi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 218(1), 286-291, Jan. 1996

A NOVEL ATP-DEPENDENT INWARD RECTIFIER POTASSIUM CHANNEL EXPRESSED PREDOMINANTLY IN GLIAL-CELLS
T TAKUMI; T ISHII; Y HORIO; K MORISHIGE; N TAKAHASHI; M YAMADA; T YAMASHITA; H KIYAMA; K SOHMIYA; S NAKANISHI; Y KURACHI
JOURNAL OF BIOLOGICAL CHEMISTRY, 270(27), 16339-16346, Jul. 1995

G(BETA-GAMMA) DIRECTLY BINDS TO THE CARBOXYL-TERMINUS OF THE G-PROTEIN-GATED MUSCARINIC K+ CHANNEL, GIRK1
A INANOBE; KI MORISHIGE; N TAKAHASHI; H ITO; M YAMADA; T TAKUMI; H NISHINA; K TAKAHASHI; Y KANAHO; T KATADA; Y KURACHI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 212(3), 1022-1028, Jul. 1995

SPERMINE GATES INWARD-RECTIFYING MUSCARINIC BUT NOT ATP-SENSITIVE K+ CHANNELS IN RABBIT ATRIAL MYOCYTES - INTRACELLULAR SUBSTANCE-MEDIATED MECHANISM OF INWARD RECTIFICATION
M YAMADA; Y KURACHI
JOURNAL OF BIOLOGICAL CHEMISTRY, 270(16), 9289-9294, Apr. 1995

MOLECULAR AND FUNCTIONAL-HETEROGENEITY OF INWARD RECTIFIER POTASSIUM CHANNELS IN BRAIN AND HEART
N TAKAHASHI; KI MORISHIGE; M YAMADA; T TAKUMI; Y KURACHI
HEART AND VESSELS, Suppl. 9, 8-11, 1995

MOLECULAR-CLONING AND FUNCTIONAL EXPRESSION OF CDNA-ENCODING A 2ND CLASS OF INWARD RECTIFIER POTASSIUM CHANNELS IN THE MOUSE-BRAIN
N TAKAHASHI; KI MORISHIGE; A JAHANGIR; M YAMADA; FINDLAY, I; H KOYAMA; Y KURACHI
JOURNAL OF BIOLOGICAL CHEMISTRY, 269(37), 23274-23279, Sep. 1994

MOLECULAR-CLONING AND FUNCTIONAL EXPRESSION OF A NOVEL BRAIN-SPECIFIC INWARD RECTIFIER POTASSIUM CHANNEL
KI MORISHIGE; N TAKAHASHI; A JAHANGIR; M YAMADA; H KOYAMA; JS ZANELLI; Y KURACHI
FEBS LETTERS, 346(2-3), 251-256, Jun. 1994

MUSCARINIC K+ CHANNELS ARE ACTIVATED BY BETA-GAMMA-SUBUNITS AND INHIBITED BY THE GDP-BOUND FORM OF ALPHA-SUBUNIT OF TRANSDUCIN
M YAMADA; YK HO; RH LEE; K KONTANI; K TAKAHASHI; T KATADA; Y KURACHI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 200(3), 1484-1490, May 1994

Current Topics in Heterotrimeric GTP-binding Proteins. Heterotrimeric G proteins and ion channels.
YAMADA Mitsuhiko; KURACHI Yoshihisa
Folia Pharmacologica Japonica, 103(6), 305-311, 1994

REGULATION OF POTASSIUM CHANNELS BY G-PROTEIN SUBUNITS AND ARACHIDONIC-ACID METABOLITES
M YAMADA; A TERZIC; Y KURACHI
HETEROTRIMERIC G-PROTEIN EFFECTORS, 238, 394-422, 1994

YM934, A NOVEL K+ CHANNEL OPENER, ACTIVATES ATP-SENSITIVE K+ CHANNELS IN CARDIAC MYOCYTES
M YAMADA; A TERZIC; FINDLAY, I; A JAHANGIR; WK SHEN; Y KURACHI
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 267(3), 1544-1549, Dec. 1993

G(KAPPA)ASTERISK AND BRAIN G(BETA-GAMMA) ACTIVATE MUSCARINIC K+ CHANNEL THROUGH THE SAME MECHANISM
M YAMADA; A JAHANGIR; Y HOSOYA; A INANOBE; T KATADA; Y KURACHI
JOURNAL OF BIOLOGICAL CHEMISTRY, 268(33), 24551-24554, Nov. 1993

Cardiovascular profile of E4080 and its analogue ER001533: Novel potassium channel openers with bradycardiac properties.
Terzic, A.; Tung, R. T.; Shen, W. K.; Yamada, M.; Kurachi, Y.
Cardiovasc. Drug Rev., 11(2), 223-233, 1993

LYSOPHOSPHATIDYLCHOLINE INHIBITS BRADYKININ-INDUCED PHOSPHOINOSITIDE HYDROLYSIS AND CALCIUM TRANSIENTS IN CULTURED BOVINE AORTIC ENDOTHELIAL-CELLS
N INOUE; K HIRATA; M YAMADA; Y HAMAMORI; Y MATSUDA; H AKITA; M YOKOYAMA
CIRCULATION RESEARCH, 71(6), 1410-1421, Dec. 1992

P-2-PURINOCEPTOR ACTIVATION STIMULATES PHOSPHOINOSITIDE HYDROLYSIS AND INHIBITS ACCUMULATION OF CAMP IN CULTURED VENTRICULAR MYOCYTES
M YAMADA; Y HAMAMORI; H AKITA; M YOKOYAMA
CIRCULATION RESEARCH, 70(3), 477-485, Mar. 1992

5-HYDROXYTRYPTAMINE INDUCES PHOSPHOLIPASE C-MEDIATED HYDROLYSIS OF PHOSPHOINOSITIDES THROUGH 5-HYDROXYTRYPTAMINE-2 RECEPTORS IN CULTURED FETAL MOUSE VENTRICULAR MYOCYTES
Y HAMAMORI; M YOKOYAMA; M YAMADA; H AKITA; K GOSHIMA; H FUKUZAKI
CIRCULATION RESEARCH, 66(6), 1474-1483, Jun. 1990

Optimizing Immunosuppressive Strategies for Enhanced Survival of Allogeneic Pluripotent Stem Cell-Derived Cardiomyocytes in Non-Human Primate Transplantation Model
Shuji Chino; Hajime Ichimura; Shugo Tohyama; Keiichi Fukuda; Takashi Shiina; James Chong; Takafumi Naito; Maki Ohya; MIkiko Kobayashi; Takuro Tomita; Mitsuhiko Yamada; Hideki Kobayashi; Naoko Shiba; Tatsuichiro Seto; Shin Kadota; Yuji Shiba
CIRCULATION RESEARCH, 135, 02 Aug. 2024

βアレスチンバイアスAT1受容体アゴニストは新しい乳幼児心不全治療薬の有力候補である
医学のあゆみ, 276(12), 1137 - 1138, 20 Mar. 2021

アンジオテンシンII1型受容体-βアレスチン経路を活性化する小児心不全治療薬の開発
川岸裕幸; 柏原俊英; 冨田拓郎; 中田勉; 山田充彦
日本循環薬理学会口演要旨集, 30th, 2020

Molecular mechanisms underlying the agonistic effect of FPL 64176 on Cav1.2 Ca²⁺ channels
冨田拓郎; 五味志文; 柏原俊英; 中田勉; 山田充彦
日本薬理学雑誌, 155(Supplement), 2020

βアレスチンバイアスアンジオテンシン1型受容体アゴニストは,新生児特有の持続性陽性変力作用を示す
川岸裕幸; 川岸裕幸; 柏原俊英; 冨田拓郎; 中田勉; 山田充彦
日本薬理学雑誌, 155(Supplement), 2020

βアレスチンバイアスアンジオテンシン1型受容体アゴニストは,新生児マウス心臓において持続的な陽性変力作用を示す
川岸裕幸; 川岸裕幸; 柏原俊英; 中田勉; 冨田拓郎; 山田充彦
日本循環薬理学会口演要旨集, 29th, 2019

新生児マウスの心臓におけるアンジオテンシンII 1型受容体-βアレスチン経路による陽性変力作用
川岸裕幸; 川岸裕幸; 柏原俊英; 中田勉; 山田充彦
日本薬理学雑誌, 153(Supplement), 2019

新生児マウスの心臓における,βアレスチン選択的アンジオテンシン受容体アゴニストによる陽性変力作用
川岸裕幸; 川岸裕幸; 柏原俊英; 中田勉; 山田充彦
日本循環薬理学会口演要旨集, 28th, 2018

心室筋活動電位中のL型Ca²⁺チャネル電流波形を決定する分子機構
山田充彦; 柏原俊英; 西村仁志; 中田勉; 川岸裕幸
日本循環薬理学会口演要旨集, 28th, 2018

PDGFはc-Src依存性に全長型Ca_v1.2L型Ca²⁺チャネルを活性化して血管平滑筋細胞を遊走させる
柏原俊英; 郭暁光; 中田勉; 山田充彦
日本薬理学雑誌, 152(Supplement), 2018

血小板由来増殖因子による血管平滑筋L型Ca²⁺チャネル活性化の分子機構と役割の解析
郭暁光; 柏原俊英; 中田勉; 山田充彦
日本循環薬理学会口演要旨集, 27th, 2017

心室筋活動電位中のL型Ca²⁺チャネル電流波形を決める分子機構の解析
柏原俊英; 郭暁光; 中田勉; 山田充彦
日本循環薬理学会口演要旨集, 27th, 2017

c-Srcによる平滑筋型Ca_v1.2 L型Ca²⁺チャネル活性化の分子機構の解析
柏原俊英; 郭暁光; 中田勉; 山田充彦
日本薬理学雑誌, 150(Supplement), 2017

萎縮骨格筋におけるL型カルシウムチャネルβサブユニットの発現増加
小松雅俊; 中田勉; 山本竜星; 柏原俊英; 加藤博之; 山田充彦
日本薬理学会関東部会プログラム・要旨集, 134th, 2016

βアドレナリン受容体刺激による心室筋活動電位中のL型Ca²⁺チャネル電流の形状制御とその分子機序
西村仁志; 西村仁志; 柏原俊英; 中田勉; IAN Findlay; 倉智嘉久; 山田充彦
日本循環薬理学会口演要旨集, 26th, 2016

心筋L型カルシウムチャネルの結合膜局在化モチーフの同定
中田勉; 柏原俊英; 山田充彦
日本循環薬理学会口演要旨集, 26th, 2016

幼若心筋細胞でアンジオテンシンIIがカゼインキナーゼ2α′βを活性化させる分子機構の解明
柏原俊英; 中田勉; 山田充彦
日本循環薬理学会口演要旨集, 26th, 2016

血小板由来増殖因子が血管平滑筋のCa_v1.2 L型Ca²⁺チャネルを活性化させる分子機構の解析
郭暁光; 柏原俊英; 中田勉; 山田充彦
日本循環薬理学会口演要旨集, 26th, 2016

G蛋白サブユニットGαoの発現亢進が拡張型心筋症モデルマウスにおける心機能低下に関与する
稲住英明; 桑原宏一郎; 桑原佳宏; 中川靖章; 木下秀之; 森内健史; 錦見俊雄; 呉林なごみ; 柏原俊英; 山田充彦; 中尾一和; 木村剛
日本循環薬理学会口演要旨集, 26th, 2016

カゼインキナーゼ2による幼若心筋細胞のL型Ca²⁺チャネル活性化の分子機構
柏原俊英; 中田勉; 山田充彦
日本循環薬理学会口演要旨集, 25th, 2015

AT₁アンジオテンシンII受容体/βアレスチン2バイアスシグナルはα’β型カゼインキナーゼ2の活性化を介して幼弱心筋細胞のL型Ca²⁺チャネルを活性化させる
柏原俊英; 中田勉; 郭暁光; 山田充彦
日本循環薬理学会口演要旨集, 24th, 2014

Regulation of the basal activity of Ca(v)1.2 cardiac L-type Ca2+ channels by casein kinase 2 alpha 'beta
Toshihide Kashihara; Tsutomu Nakada; Mitsuhiko Yamada
JOURNAL OF PHARMACOLOGICAL SCIENCES, 124, 85P - 85P, 2014

CaチャネルアゴニストFPL64176の作用機序の検討
五味志文; 五味志文; 柏原俊英; 中田勉; 池田宇一; 山田充彦
日本薬理学会関東部会プログラム・要旨集, 129th, 2013

カゼインキナーゼ2による心筋Ca_V1.2L型Ca²⁺チャネルの基礎活性制御の分子機構の解析
柏原俊英; 中田勉; 山田充彦
日本循環薬理学会口演要旨集, 23rd, 2013

The molecular mechanism by which chronic and excessive beta(1)-adrenergic stimulation remodels ventricular excitation-contraction coupling
Toshihide Kashihara; Tsutomu Nakada; Simmon Gomi; Masamichi Hirose; Mitsuhiko Yamada
JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S94 - S94, 2013

Regulation of the basal activity of Ca(v)1.2 cardiac L-type Ca2+ channel by casein kinase 2
Toshihide Kashihara; Tsutomu Nakada; Shimmon Gomi; Mitsuhiko Yamada
JOURNAL OF PHARMACOLOGICAL SCIENCES, 121, 77P - 77P, 2013

ニコランジルの慢性投与は、Gq-蛋白遺伝子改変マウスにおいて心不全誘発心室性不整脈の発生を抑制する
弘瀬 雅教; 斉藤 麻希; 田辺 由幸; 中山 貢一; 山田 充彦
日本薬理学雑誌, 137(1), 5P - 5P, Jan. 2011

The junctional membrane-targeting motif in C-terminal of L-type calcium channel alpha(1c) subunits
Tsutomu Nakada; Flucher Bernhard; Xiaona Sheng; Toshihide Kashihara; Toshihide Shibazaki; Masamichi Hirose; Mitsuhiko Yamada
JOURNAL OF PHARMACOLOGICAL SCIENCES, 115, 112P - 112P, 2011

Beta2-adrenergic receptor-mediated activation of G(i/o) proteins causes a decrease in the t-tubular L-type Ca2+ channel current density in failing ventricular myocytes
Toshihide Kashihara; Tsutomu Nakada; Xiaona Sheng; Toshihide Shibasaki; Masamichi Hirose; Mitsuhiko Yamada
JOURNAL OF PHARMACOLOGICAL SCIENCES, 115, 97P - 97P, 2011

Olmesartan inhibits atrial remodeling in a mouse model of chronic heart failure
Masamichi Hirose; Yasuchika Takeishi; Hisashi Shimojo; Toshihide Kashihara; Tsutomu Nakada; Koichi Nakayama; Mitsuhiko Yamada
JOURNAL OF PHARMACOLOGICAL SCIENCES, 115, 109P - 109P, 2011

Olmesartan Inhibits GTP-Binding Protein Alpha q-Induced Atrial Remodeling in Transgenic Mice.
Masamichi Hirose; Yasuchika Takeishi; Hisashi Shimojo; Toshihide Kashihara; Tsutomu Nakada; Ulrike Mende; Minoru Hongo; Mitsuhiko Yamada
CIRCULATION, 122(21), Nov. 2010

心筋L型カルシウムチャネルの細胞内局在を決定する分子機構の解析
中田勉; FLUCHER Bernhard E.; 柏原俊英; SHENG Xiaona; 柴崎利英; 弘瀬雅教; 山田充彦
日本心臓血圧研究振興会研究業績集, (25), 2010

Nifedipine inhibits L-type Ca2+ channels by stabilizing the ultraslow voltage-dependent inactivation
Xiaona Sheng; Tsutomu Nakada; Toshihide Kashihara; Masamichi Hirose; Toshifumi Aoyama; Mitsuhiko Yamada
JOURNAL OF PHARMACOLOGICAL SCIENCES, 112, 201P - 201P, 2010

Involvement of pertussis toxin-sensitive G proteins (G(i/o)) in a decrease in the T-tubular L-type Ca2+ channel current density in failing myocytes
Toshihide Kashihara; Miwa Horiuchi; Nagomi Kurebayashi; Tsutomu Nakata; Xiaona Sheng; Masamichi Hirose; Mitsuhiko Yamada
JOURNAL OF PHYSIOLOGICAL SCIENCES, 60, S94 - S94, 2010

Contribution of pertussis toxin-sensitive G proteins (G(i/o)) to a decrease in the T-tubular L-type Ca2+ channel current density in failing myocytes
Toshihide Kashihara; Nagomi Kurebayashi; Miwa Horiuchi; Tsutomu Nakada; Xiaona Sheng; Masamichi Hirose; Mitsuhiko Yamada
JOURNAL OF PHARMACOLOGICAL SCIENCES, 112, 96P - 96P, 2010

Phlorizin Prevents Ischemia-Induced Ventricular Tachyarrhythmia in Langendorff-perfused Guinea Pig Hearts
Masamichi Hirose; Tsutomu Nakada; Toshihide Shibazaki; Toshihide Kashihara; Mitsuhiko Yamada
CIRCULATION, 120(18), S655 - S655, Nov. 2009

Nicorandil Inhibits Ventricular Remodeling and Arrhythmias in a Mouse Model of Chronic Heart Failure
Masamichi Hirose; Yasuchika Takeishi; Hisashi Shimojo; Ayako Nishio; Tsutomu Nakada; Isao Kubota; Ulrike Mende; Minoru Hongo; Kiyoshi Matsumoto; Mitsuhiko Yamada
CIRCULATION, 120(18), S886 - S886, Nov. 2009

Changes in L-type Ca2+ channel density in t-tubules caused by isoproterenol-induced cardiac hypertrophy
Miwa Horiuchi; Hideho Ueda; Tsutomu Nakada; Masamichi Hirose; Mitsuhiko Yamada
JOURNAL OF PHARMACOLOGICAL SCIENCES, 109, 81P - 81P, 2009

DIACYLGLYCEROL KINASE zeta RESTORES G alpha q-INDUCED ATRIAL STRUCTURAL REMODELING IN TRANSGENIC MICE
Masamichi Hirose; Yasuchika Takeishi; Hisashi Shimojo; Takeshi Niizeki; Tsutomu Nakada; Isao Kubota; Mitsuhiko Yamada
JOURNAL OF PHYSIOLOGICAL SCIENCES, 59, 121 - 121, 2009

I-kr AND I-ks CHANNEL SUPPRESSION CAUSES EARLY AFTERDEPOLARIZATIONS BY PREVENTING DEACTIVATION OF L-TYPE Ca2+ CHANNELS IN VENTRICULAR MYOCYTES
Mitsuhiko Yamada; Keisuke Ohta; Atsunori Niwa; Natsuko Tsujino; Tsutomu Nakada; Masamichi Hirose
JOURNAL OF PHYSIOLOGICAL SCIENCES, 59, 126 - 126, 2009

Diacylglycerol kinase zeta inhibits G alpha q-induced atrial fibrillation in transgenic mice
Masamichi Hirose; Yasuchika Takeishi; Takeshi Niizeki; Isao Kubota; Tsutomu Nakada; Mitsuhiko Yamada
JOURNAL OF PHARMACOLOGICAL SCIENCES, 109, 69P - 69P, 2009

OE-368 Cardioprotection of MCP-1 Against Ischemia/Reperfusion Injury is Mediated Through a ROS-dependent but K_ Channel-independent Pathway(Neurohumoral factors(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Morimoto Hajime; Takahashi Masafumi; Hirose Masamichi; Kawaguchi Masanori; Ise Hirohiko; Yamada Mitsuhiko; Ikeda Uichi
Circulation journal : official journal of the Japanese Circulation Society, 72, 272 - 272, 01 Mar. 2008

OE-147 Cardiac-Specific Overexpression of Diacylglycerol kinase ζ Prevents the Generation of Cardiac Arrhythmias in Constitutively Active G α q-Expressed Transgenic Mice(Arrhythmia, basic(01)(A),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Hirose Masamichi; Takeishi Yasuchika; Niizeki Takeshi; Kubota Isao; Yamada Mitsuhiko
Circulation journal : official journal of the Japanese Circulation Society, 72, 217 - 217, 01 Mar. 2008

Thrombin activates non-selective cation channels in human vascular endothelial cells
Natsuko Tsujino; Tsutomu Nakada; Yoshiko Kawai; Masamichi Hirose; Mitsuhiko Yamada
JOURNAL OF PHARMACOLOGICAL SCIENCES, 106, 86P - 86P, 2008

Analysis of postnatal development of transverse tubules in rat ventricular myocytes with a fluorescence microscopy
Atsunori Niwa; Tsutomu Nakada; Masamichi Hirose; Mitsuhiko Yamada
JOURNAL OF PHARMACOLOGICAL SCIENCES, 106, 106P - 106P, 2008

Effects of nicorandil on atrial electrophysiological parameters during ischemia in isolated arterially-perfused canine atria
Masamichi Hirose; Shiharu Yano; Natsuko Tsujino; Tsutomu Nakada; Atsunori Niwa; Mitsuhiko Yamada
JOURNAL OF PHARMACOLOGICAL SCIENCES, 106, 121P - 121P, 2008

The contraction of Mueller's smooth muscle is mediated by alpha(1A)-adrenergic receptors
Shiharu Yano; Masamichi Hirose; Tsutomu Nakada; Kiyoshi Matsuo; Mitsuhiko Yamada
JOURNAL OF PHARMACOLOGICAL SCIENCES, 106, 118P - 118P, 2008

Spatial difference in the effect of pilsicainide on atrial fibrillation prevention in anesthetized canine hearts
Masamichi Hirose; Mitsuhiko Yamada
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 41(6), 1064 - 1064, Dec. 2006

Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes
H Hibino; A Fujita; K Iwai; M Yamada; Y Kurachi
FASEB JOURNAL, 19(5), A1161 - A1161, Mar. 2005

Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes
H Hibino; A Fujita; K Iwai; M Yamada; Y Kurachi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 213P - 213P, 2005

shikkan byotai chiryoyaku sayo no moderushisutemu no kaihatsu
KITAOKA Hiroko; SUZUKI Shingo; YAMADA Mitsuhiko; KURACHI Yoshihisa
慶應醫學, 81(2), 105 - 108, 25 Jun. 2004

In Silico Human Project:網羅的解析の先を目指して (特集 網羅的解析の先に見えてくるもの--ゲノム解析,プロテオミクスの最前線とその未来) -- (新しいユニークな網羅的解析手法)
鈴木 慎悟; 北岡 裕子; 山田 充彦
細胞工学, 23(4), 444 - 447, Apr. 2004

OJ-019 Opening of Cardiovascular ATP-Sensitive K^+ Channels is Induced by Dimerization of Nucleotide-Binding Domains of Sulfonylurea Receptors 2A and 2B(Excitation-Contraction Coupling/Ion Channel (A) : OJ3)(Oral Presentation (Japanese))
Yamada Mitsuhiko; Kurachi Yoshihisa
Circulation journal : official journal of the Japanese Circulation Society, 68, 236 - 236, 01 Mar. 2004

薬物作用シミュレーションの創薬での役割 (バーチャルヒューマン)
山田 充彦; 辻前 健司; 鈴木 慎悟
医学のあゆみ, 205(7), 458 - 462, 17 May 2003

Interaction of Nucleotides and Nucleotide-Binding Domains of Sulfonylurea Receptors Determines the Potency of Nicorandil in Activating Cardiovascular ATP-Sensitive K^+ Channels
Yamada Mitsuhiko; Matsushita Kenji; Kurachi Yoshihisa
Circulation journal : official journal of the Japanese Circulation Society, 67, 412 - 412, 01 Mar. 2003

C-terminal tails of sulfonylurea receptor 2 subtypes control differential binding of ADP to the second nucleotide binding domain
T Matsuoka; K Matsushita; A Inanobe; M Yamada; Y Kurachi
CIRCULATION, 106(19), 90 - 90, Nov. 2002

Structure and function of cardiac ATP-sensitive K^+ channels.
YAMADA Mitsuhiko; KURACHI Yoshihisa
心電図 = Electrocardiology, 19(2), 111 - 119, 25 Mar. 1999

P108 G蛋白制御性内向き整流性カリウムチャネル(GIRK1)のSplicing variant(GIRK1B)の生化学的検討
松本 重人; 倉智 嘉久; 近藤 千香子; 松澤 佑次; 山田 充彦
Japanese circulation journal, 63(1), 476 - 476, 01 Mar. 1999

Molecular structure and function of cardiovascular ATP-sensitive potassium channels
M Yamada; E Satoh; C Kondo; VP Repunte; Y Kurachi
POTASSIUM ION CHANNELS, 46, 387 - 415, 1999

心血管系のATP感受性Kチャネルの構造と機能
山田 充彦; 倉智 嘉久
心電図 = Electrocardiology, 18(5), 588 - 588, 31 Aug. 1998

0063 SUR/Kir6.0複合体カリウムチャネルの細胞内ヌクレオチドによるゲーティングとピナシジルによるその調節機構
佐藤 栄作; 山田 充彦; 近藤 千香子; 奥山 裕司; 磯本 正二郎; 堀尾 嘉幸; 倉智 嘉久
Japanese circulation journal, 62, 120 - 120, 28 Feb. 1998

0061 Single cell RT-PCR法による心筋I_チャネルの構成サブユニットの解析
磯本 正二郎; 日比野 浩; 山田 充彦; 堀尾 嘉幸; 倉智 嘉久
Japanese circulation journal, 62, 120 - 120, 28 Feb. 1998

0064 G蛋白制御内向き整流カリウムチャネル(GIRK1)のsplicing variant(GIRK1B)の心筋型K_Gチャネル活性化抑制機構についての検討
松本 重人; 稲野辺 厚; 近藤 千香子; 山田 充彦; 堀尾 嘉幸; 倉智 嘉久; 松沢 佑次
Japanese circulation journal, 62, 121 - 121, 28 Feb. 1998

0062 ATP感受性カリウムチャネルの構造 : 機能相関の解析
近藤 千香子; 山田 充彦; 奥山 裕司; VEZ REPUNTE; 堀尾 嘉幸; 倉智 嘉久; 佐藤 栄作; 松沢 佑次; 磯本 正二郎
Japanese circulation journal, 62, 120 - 120, 28 Feb. 1998

Identification and functional analysis of variant SUR1 in Japanese with non-insulin-dependent diabetes mellitus
Y Tanizawa; Y Ota; H Inoue; VP Repunte; M Yamada; K Ueda; J Nomiyama; Y Kurachi; MA Permutt; J Bryan; L AguilarBryan; Y Oka
DIABETOLOGIA, 40, 645 - 645, Jun. 1997

0147 心臓に発現しているATP依存性内向き整流カリウムチャネルROMK1(Kir1.1a)のisoformeのクローニングおよびその機能解析
近藤 千香子; 磯本 正二郎; 松本 重人; 山田 充彦; 堀尾 嘉幸; 倉智 嘉久; 山下 静也; 竹村 芳; 松沢 祐次
Japanese circulation journal, 61, 147 - 147, 05 Mar. 1997

0141 心筋型ATP感受性K^+チャネルクローンの基本的性質の解析
奥山 裕司; 山田 充彦; 磯本 正二郎; 近藤 千香子; 松本 重人; 堀尾 嘉幸; 倉智 嘉久; 堀 正二
Japanese circulation journal, 61, 146 - 146, 05 Mar. 1997

P388 アセチルコリンによる心筋細胞ムスカリン性カリウムチャネルの活性化機構の検討 : 理論モデルによる検討
細谷 幸雄; 山田 充彦; 倉智 嘉久
Japanese circulation journal, 61, 483 - 483, 05 Mar. 1997

Molecular Aspects of ATP-Sensitive K^+ Channels in the Cardiovascular System
ISOMOTO Shojiro; YAMADA Mitsuhiko; HORIO Yoshiyuki; KURACHI Yoshihisa
The Japanese journal of physiology, 47, S5 - S6, 1997

細胞内Mg^<2+>およびポリアミンによる内向き整流K^+チャネルK_-2の内向き整流特性が生じる分子機構
山田 充彦; 山下 武志; 倉智 嘉久
日本分子生物学会年会プログラム・講演要旨集, 19, 309 - 309, 01 Aug. 1996

Muller細胞におけるATP依存性内向き整流カリウムチャネルK_-2(Kir4.1)の発現
堀尾 嘉幸; 山田 充彦; 多田 仁彦; 稲野辺 厚; 伊東 稔; 倉智 嘉久
日本分子生物学会年会プログラム・講演要旨集, 19, 312 - 312, 01 Aug. 1996

An ATP-dependent inwardly rectifying potassium channel, K-AB-2(Kir4.1), expresses in retinal Muller cells
Y Horio; H Hibino; A Inanobe; M Ito; M Yamada; Y Tada; Y Kurachi
JOURNAL OF GENERAL PHYSIOLOGY, 108(2), 61 - 61, Aug. 1996

Kチャネルの分子生物学
山田充彦
治療学, 30, 377 - 382, 1996

THE STUDY OF COOPERATIVE ACTIVATION OF THE CARDIAC MUSCARINIC K^+ CHANNEL BY GTP USING ALLOSTERIC MODEL.
HOSOYA Yukio; ITO Hiroyuki; YAMADA Mitsuhiko; KURACHI Yoshihisa
Japanese circulation journal, 59(7), 418 - 419, 20 Jun. 1995

0634 アロステリック理論モデルによる心筋細胞ムスカリン性K^+チャネル活性化の検討
細谷 幸雄; 伊藤 博之; 山田 充彦; 倉智 嘉久
Japanese circulation journal, 59, 202 - 202, 01 Mar. 1995

SI-1 アセチルコリンによる心房筋細胞のムスカリン性K^+チャネル活性化の分子機構
山田 充彦; 倉智 嘉久
Japanese circulation journal, 59, 4 - 4, 01 Mar. 1995

Molecular mechanism of the G protein regulation of inwardly rectifying potassium channels
M. Yamada; Y. Kurachi; Y. Hosoya; A. Inanobe
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 40(15), 2297 - 2306, 1995

MOLECULAR CHARACTERIZATION OF A NOVEL SUBFAMILY OF INWARD RECTIFIER POTASSIUM CHANNELS
T TAKUMI; T ISHI; K SOHMIYA; KI MORISHIGE; N TAKAHASHI; M YAMADA; S NAKANISHI; Y KURACHI
JOURNAL OF GENERAL PHYSIOLOGY, 104(6), A9 - A9, Dec. 1994

MOLECULAR AND FUNCTIONAL-HETEROGENEITY OF INWARD-RECTIFIER POTASSIUM CHANNELS IN MOUSE HEART
A JAHANGIR; K MORISHIGE; A TERZIC; N TAKAHASHI; M YAMADA; Y KURACHI
CIRCULATION, 90(4), 415 - 415, Oct. 1994

ACTIVATION OF MUSCARINIC K+ CHANNEL BY GK-ASTERISK AND BRAIN G-BETA-GAMMA THROUGH THE SAME MECHANISM
M YAMADA; A JAHANGIR; Y HOSOYA; A INANOBE; T KATADA; Y KURACHI
BIOPHYSICAL JOURNAL, 66(2), A30 - A30, Feb. 1994

熱血 循環器学 洋學社 井上信孝編集
山田充彦, 新しい小児心不全治療薬の開発をめざして
洋學社, 1-15 2019

倉智 嘉久編：別冊・医学のあゆみイオンチャネル最前線update
山田充彦, ヌクレオチドと薬物による心血管系ATP感受性K+チャネル活性化の分子機構
医歯薬出版株式会社，東京, pp 101-107 2005

神経障害性疼痛へのHCN チャネルの関与
山田充彦、張昊、柏原俊英、中田勉、田中聡、石田公美子、布施谷仁志、川岸裕幸、中村博之、清沢研一、川真田樹人
第100回日本生理学会大会, 15 Mar. 2023

心不全治療薬としてのレニン・アンジオテンシン・アルドステロン系抑制薬：その薬理と臨床（基礎編）
山田充彦
第96回日本薬理学会年会, 03 Dec. 2022, Invited

Molecular Mechanism underlying Initiation ＆ Maturation of Heartbeat
Mitsuhiko Yamada, Tomoe Nakamura-Nishitani
第99回日本生理学会大会, 17 Mar. 2022

低分子βアレスチンバイアスAT1受容体アゴニストの開発
山田充彦、小松弘嗣
第95回日本薬理学会年会, 07 Mar. 2022

T1アンジオテンシン受容体を利用した新たな胎児・新生児心不全治療法の開発
山田充彦
日本胎児心臓病学会第28回学術集会, 18 Feb. 2022, Invited

Cardiac AT Receptor/β-Arrestin Pathway is a Neonatal-Specific Druggable Target for Pediatric Heart Failure
Mitsuhiko Yamada, Hiroyuki Kawagishi, Shin Kadota, Yuji Shiba, Sachio Morimoto
Experimental Biology 2021, 27 Apr. 2021

Cardiac AT1 receptor/-arrestin pathway is a neonatal-specific druggable target for pediatric heart failure.
Mitsuhiko Yamada
CVMV2021, 12 Mar. 2021

Cardiac AT1 receptor/-arrestin axis is a novel druggable target for pediatric heart failure
Mitsuhiko Yamada, Hiroyuki Kawagishi, Shin Kadota, Cheng-Kun Du, Yuji Shiba, Sachio Morimoto
The 12th Annual Meeting of Japanese Safety Pharmacology Society, 12 Mar. 2021, Invited

小児疾患治療薬の新たな薬物標的の探索
山田充彦
第94回日本薬理学会年会, 09 Mar. 2021

Postnatal loss of gp130 caused impaired cardiac contractility accompanied by inhibition of physiological proliferation of cardiomyocytes.
Hiroyuki Kawagishi, Tsutomu Nakada, Takuro Numaga-Tomita, Mitsuhiko Yamada
NIPS International Meeting on Cardiovascular Physiology 2020, Dec. 2020

小児心不全では、AT1アンジオテンシン受容体を抑制すべきか刺激すべきか？
山田充彦
第56回日本小児循環器学会総会・学術集会, 24 Nov. 2020

Molecular mechanism underlying cardiac early afterdepolarization induced by IKr and IKs suppression.
Yamada, M.
The 11th Annual Meeting of Japanese Safety Pharmacology Society, Feb. 2020, Invited

A beta arrestin-bias AT1 receptor agonist improves the survival of neonatal knock-in mice bearing a human dilated cardiomyopathy mutation.
Yamada, M.
The 50th NIPS International Symposium. ‘MIRACLES’ in Cardiovascular Physiology, Dec. 2019

新生児マウスにおける、gp130受容体を介した心筋細胞の発達機構
川岸裕幸、Maite LARRA AGA、冨田(沼賀)拓郎、中田勉、山田充彦
筋生理の集い, Dec. 2019

βアレスチンバイアスアンジオテンシン1型受容体アゴニストは、新生児マウス心臓において持続的な陽性変力作用を示す
川岸裕幸、柏原俊英、中田勉、冨田拓郎、山田充彦
第29回日本循環薬理学会, Nov. 2019

除神経モデルマウスの骨格筋におけるホスホランバンの発現量の増加
中田勉、小松雅俊、山田充彦
第66回中部日本生理学会, Oct. 2019

小胞体CaセンサーSTIM1によるCav1.2チャネル制御機構の解明
冨田拓郎、高橋弘毅、山田充彦
第66回中部日本生理学会, Oct. 2019

Molecular mechanisms underlying the agonistic effect of FPL64176 on CaV1.2 Ca2+ channels
冨田拓郎、五味志文、柏原俊英、中田勉、山田充彦
第141回日本薬理学会関東部会, Oct. 2019

心室筋活動電位内でのL型Ca2+電流波形を決定する分子機構の検討
山田充彦、西村仁志、柏原俊英
学術セミナー「分子から個体へ：俯瞰と接近の生命科学」, Oct. 2019

マウス心筋細胞の生下後の機能的最終分化のメカニズムの解析
川岸裕幸、中田勉、山田充彦
第140回日本薬理学会関東部会, Jul. 2019

Molecular mechanisms underlying spatiotemporal regulation of L-type Ca2+ channels in muscles. Logic of life: ion channel structure, function and physiology.
Yamada, M.
International commemorative symposium in celebration of retirement of Professor Yoshihisa Kurachi, Mar. 2019

プロスタノイドEP4受容体を介する後根神経節A細胞のIh電流増強による神経障害性疼痛の発症
山田充彦、張昊、柏原俊英、中田勉、田中聡、石田公美子、布施谷仁志、川岸裕幸、清沢研吉、川眞田樹人
第92回日本薬理学会年会, Mar. 2019

c-Srcによる全長型CaV1.2サブユニットを有するL型Ca2+チャネルの活性を介したPDGFによる増殖型血管平滑筋細胞の遊走
中田勉、郭暁光、柏原俊英、青山俊文、山田充彦
第92回日本薬理学会年会, Mar. 2019

マウス個体を用いた心筋細胞成熟化因子の同定
川岸裕幸、中田勉、山田充彦
第92回日本薬理学会年会, Mar. 2019

Interaction of junctophilins and the CaV1.1 is essential for the skeletal muscle contraction.
Nakada, T., Kashihara, T., Komatsu, M., Yamada, M.
FAOPS 2019, Mar. 2019

EP4 receptor-mediated augmentation of Ih currents in A DRG neurons underlies neuropathic pain.
Yamada, M., Zhang, H., Kashihara, T., Nakada, T., Tanaka, S., Ishida, K., Fuseya, S., Kawagishi, H., Kiyosawa, K., Kawamata, M.
FAOPS 2019, Mar. 2019

G蛋白サブユニットGαoのCa2+handling恒常性および心収縮能維持における意義の解明
稲住 英明, 桑原 宏一郎, 桑原 佳宏, 中川 靖章, 木下 秀之, 錦見 俊雄, 呉林 なごみ, 山田 充彦, 柏原 俊英, 中尾 一和, 木村 剛
日本臨床分子医学会学術総会プログラム・抄録集, Apr. 2018

HFpEFにおける心筋興奮収縮連関の変化
山田 充彦, Kashihara Toshihide
日本循環器学会学術集会抄録集, Mar. 2017

Pharmacology
Jul. 2004 - Present
Shinshu University

Pharmacology
Jun. 2002 - Jun. 2004
Osaka University

Pharmacology
Apr. 1994 - Mar. 1998
Osaka University

Pharmacology
Shinshu University

Pharmacology
Shinshu University

器官・組織・細胞機能研究方法特論
Shinshu University

Apr. 2018 - Present
Japanese Society of Pediatric Cardiology and Cardiac Surgery

Apr. 1994 - Present
Japanese Society of Pharmacology

The Japanese Circulation Society

Physiological Society of Japan

The Japanese Society of Electrocardiology

The American Physiological Society

ISHR

Biophysical Society

心筋細胞AT1受容体に共役する信号伝達経路の発達依存的変化の意義と機序の解明
科学研究費補助金（基盤研究(C)（一般））, 基盤研究(C)（一般）
01 Apr. 2023 - 2026

Application of a beta-arrestin-biased agonist, TRV027 to pediatric heart failure
共同研究, Trevena Inc.
26 Jul. 2021

離乳期までの心筋細胞AT1受容体のダイナミックな生命維持機能を活用した世界初低分子小児心不全治療薬の開発
受託研究, 日本医療研究開発機構(AMED)
2021 - 2022

小分子βアレスチンバイアスAT1受容体アゴニストの開発
共同研究, インタープロテイン株式会社
Sep. 2020

⼼筋ジャンクトフィリン2の発現・機能異常が，⼼不全・不整脈などの病態形成に与える影響の検討
奨学寄附金, 田辺三菱製薬グループ
2020

これまでにない⽅法でAT1アンジオテンシン受容体（AT1R）を利⽤した⼩児⼼ 不全治療法の開発
奨学寄附金, 第一三共株式会社
2020

選択的βアレスチン刺激による小児心不全治療法の開発
奨学寄附金, ファイザー株式会社
2019

Identification of factors promoting final differentiation of cardiac myocytes after birth
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
01 Apr. 2018 - 31 Mar. 2021

⼩児⼼不全の新しい薬物療法の開発
奨学寄附金, 第一三共株式会社
2018

⼩児⼼不全の新しい治療法の開発
奨学寄附金, ブリストル・マイヤーズ スクイブ株式会社
2018

AT1アンジオテンシン受容体βアレスチンバイアスアゴニストが若年性心不全に与える効果の検討
ファイザー株式会社
2018

サルコペニアにおいて筋⼒低下が⽣じるメカニズムの解明
奨学寄附金, MSD株式会社
2018

βアレスチンバイアスAT1受容体アゴニストを⽤いた⼩児⼼不全治療法の開発
塩野義製薬
2018

βアレスチンバイアスAT1受容体アゴニストを⽤いた⼩児⼼不全治療法の開発
バイエル薬品株式会社
2018

⼩児⼼不全の新しい薬物療法の開発
奨学寄附金, 第一三共株式会社
2017

βアレスチンバイアスAT1受容体アゴニストを⽤いた⼩児⼼不全治療法の開発
バイエル薬品株式会社
2017

βアレスチンバイアスAT1受容体アゴニストを⽤いた⼩児⼼不全治療法の開発
塩野義製薬
2017

βアレスチンバイアスAT1受容体アゴニストを⽤いた⼩児⼼不全治療法の開発
武田薬品工業株式会社
2017

AT1アンジオテンシン受容体βアレスチンバイアスアゴニストが若年性心不全に与える効果の検討
ファイザー株式会社
2017

AT1アンジオテンシン受容体βアレスチンバイアスアゴニストが若年性心不全に与える効果の検討
ファイザー株式会社
2016

心不全の心室筋細胞でのL型Ca2+チャネルのリモデリングに関する研究
奨学寄附金, アステラス製薬
2016

Discovery of novel Nav1.7 inhibitors by using bioinformatics
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A)
Shinshu University
01 Apr. 2015 - 31 Mar. 2019

Elucidation of epigenetic regulation of gene expresson involved in maintaining cardiac function and metabolism
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
01 Apr. 2014 - 31 Mar. 2017

Changes in expression of L-type calcium channel subunits in skeletal muscle with aging.
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research
Shinshu University
01 Apr. 2013 - 31 Mar. 2016

Localization and function of L-type calcium channels in skeletal muscle is regulated by junctophilins.
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
01 Apr. 2012 - 31 Mar. 2015

Quantitative analysis of the open-state affinity of L-type calcium channel blockers and modeling of their inhibitory actions
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
2009 - 2011

Gqマウス心不全モデルを用いたニコランジルの心筋繊維化への抑制効果
受託研究, 中外製薬(株）
2008 - 2009

新規Caチャネル阻害薬を用いた、がん細胞の増殖抑制法の研究
受託研究, 小野薬品工業(株）
2008 - 2009

イオンチャネルとトランスポーターのクロストークに関するｋｒん旧
受託研究, キッセイ薬品工業(株）
2007 - 2009

虚血による貫壁性活動電位幅不均一性に対するNicorandilの抑制効果
受託研究, 中外製薬(株）
2007 - 2008

新規Caチャネル阻害薬を用いた、がん細胞の増殖抑制法の研究
受託研究, 小野薬品工業(株）
2007 - 2008

イヌ虚血心室筋の頻拍性不整脈発生に対するニコランジルの保護効果
受託研究, 中外製薬(株）
2006 - 2007

新規Caチャネル阻害薬を用いた、がん細胞の増殖抑制法の研究
受託研究, 小野薬品工業(株）
2006 - 2007

虚血による貫壁性活動電位幅不均一性に対するNicorandilの抑制効果
受託研究, 中外製薬(株）
2005 - 2006

Analysis of the molecular mechanism underlying the regulation of ATP-sensitive K+ channels by drugs
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
2004 - 2006

Molecular mechanisms for functional and spatial regulation of the G protein-gated potassium channel
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A)
Osaka University
2003 - 2005

Regeneration of myocardium using bone marrow cells for the treatment of severe heart failure
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
National Cardiovascular Center Research Institute
2002 - 2004

Role of Muscarinic K Channels in Parasympthetic Regulation of Heart Beat
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
2000 - 2002

心筋細胞の再生療法に関する研究：心筋細胞の電気生理学的分化とその制御因子の同定
2000 - 2002

カルシウムチャネルによる心・血管細胞収縮調節機構とその異常
1999 - 2001

動脈硬化血管の収縮異常と血管平滑筋型ATP感受性K^+チャネル
科学研究費助成事業, 日本学術振興会, 特定領域研究(A)
国立循環器病センター
1998 - 1998

Investigation of Molecular Diversity of ATP-Sensitive K^+ Channels.
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Osaka University Faculty of Medicine
1997 - 1998

Its functional significance and molecular mechanism
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for international Scientific Research
Osaka University
1997 - 1998

Studies of inwardly rectifying K^+ channels and an approach to develop new methods for assaying K^+ channel activity.
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A)
Osaka University
1996 - 1998

Analysis of the polyamine-binding sites in inwardly rectifying K^+ channels.
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
OSAKA UNIVERSITY
1996 - 1997

Molecular Mechanism in Regulation of Inwardly Rectifying Potassium Channel and its Functional Disorder
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A)
Osaka University
1995 - 1998

Molecular Analysis of Inward Rectifier K^+channels in CNS
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for international Scientific Research
Osaka University
1995 - 1996

内向き整流カリウムチャネルの細胞内物質によるゲーティング機構の解析
科学研究費助成事業, 日本学術振興会, 奨励研究(A)
大阪大学
1995 - 1995

内向き整流特性カリウムチャネルの神経伝達調節と可塑性における役割
科学研究費助成事業, 日本学術振興会, 重点領域研究
大阪大学
1995 - 1995

3量体G蛋白による心筋細胞カリウムチャネル制御の分子機構
科学研究費助成事業, 日本学術振興会, 重点領域研究
大阪大学
1995 - 1995

Molecular cloning of ATP-sensitive K^+ channels and development of the method evaluating K^+ channel openers.
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A)
Osaka University
1994 - 1996

心筋細胞ATP依存性カリウムチャネルの受容体および機械刺激依存性制御とその異常
科学研究費助成事業, 日本学術振興会, 重点領域研究
大阪大学
1994 - 1994

三量体G蛋白質による心筋細胞カリウムチャネル制御の分子機構
科学研究費助成事業, 日本学術振興会, 重点領域研究
大阪大学
1994 - 1994

NOによる中枢神経細胞内向き整流カリウムチャネルの抑制性修飾とその分子機構
科学研究費助成事業, 日本学術振興会, 重点領域研究
大阪大学
1994 - 1994

Regulatory mechanisms of receptor-coupled signal transduction and its pathophysiologic state
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for General Scientific Research (B)
Kobe University School of Medicine
1988 - 1989

Physiological, pathophysiological and pharmacological analyses of cardiac L-type Ca2+ channels

Development of therapeutics for pediatric heart failure

Investigation of the mechanism underlying metanephrogenesis

⼩児⼼不全の新しい治療法の開発
奨学寄附金, アステラス製薬

市民公開講座：心不全の予防・診療・リハビリテーションの最前線
オンライン, 25 Oct. 2020 - 25 Oct. 2020

ペプチドで小児心不全治療 小児用創薬のヒントに
日本経済新聞, 07 Dec. 2020

新生児や乳児の心臓 収縮力を高める仕組み解明
信濃毎日新聞, 30 Nov. 2020

生理研研究会「心血管研究会」
Planning etc
松本, 13 Oct. 2022 - 14 Oct. 2022

Planning etc
生理研研究会「心血管研究会」, オンライン, 18 Nov. 2021 - 19 Nov. 2021

Planning etc
第143回日本薬理学会関東部会, オンライン, 24 Oct. 2020 - 24 Oct. 2020

Planning etc
第26回日本循環薬理学会, 信州大学医学部附属病院外来棟　大会議室他, 02 Dec. 2016 - 02 Dec. 2016