ＭＤ

Pharmacology, General pharmacology

Cardiology, Cardiovascular Medicine

Neuroscience-general, Neurophysiology / General neuroscience

Clinical pharmacy, General physiology

Embryonic medicine and pediatrics, Embryonic medicine and pediatrics

2004
Professor, Dept. Mol. Pharamacol. Shinshu Univ. Sch. Med.

2002 - 2004
Associate Professor, Dept. Pharamacol. II, Osaka Univ. Grad. Sch. Med.

1998 - 2002
Assitant Professor, Dept. Card. Physiol., National Cardiovasc. Ctr. Res. Inst.

1991 - 1992
兵庫病院内科医師

1990 - 1991
佐用共立病院内科医師

1989 - 1990
兵庫病院内科医師

1987 - 1989
医員

1984 - 1987
医員（研修医）

1998
Assistant Professor, Dept. Pharmacol. II, Osaka Univ. Sch. Med.

1992 - 1994, Postdoctal fellow, Dev. Of Cardiovascular Diseases, Dept. Intern. Med., Mayo Clinic

1978 - 1984, Kobe University, Faculty of Medicine, School of Medicine

代議員, 日本薬理学会

2005
第５回医科学応用研究財団助成による日本心電学会論文賞

1993
財団法人循環器学研究振興財団内田賞

Role of Cytokine Receptor gp130 in Functional Development of the Neonatal Mouse Heart
KAWAGISHI Hiroyuki;YAMADA Mitsuhiko
The Shinshu Medical Journal, 70(6), 373-382, 10 Dec. 2022

A reconstituted depolarization-induced Ca2+ release platform for validation of skeletal muscle disease mutations and drug discovery.
Murayama T, Kurebayashi N, Numaga-Tomita T, Kobayashi T, Okazaki S, Yamashiro K, Nakada T, Mori S, Ishida R, Kagechika H, Yamada M, Sakurai T.
J Gen Physiol., 154(12), e202213230, Nov. 2022, Refereed

小児期特有のアンジオテンシンシグナルと、その小児心不全治療への応用
山田充彦
Cardiac Practice, 32, 128-133, 2022, Invited
Lead, Last, Corresponding

NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca2+ Homeostasis.
Inazumi H, Kuwahara K, Nakagawa Y, Kuwabara Y, Numaga-Tomita T, Kashihara T, Nakada T, Kurebayashi N, Oya M, Nonaka M, Sugihara M, Kinoshita H, Moriuchi K, Yanagisawa H, Nishikimi T, Motoki H, Yamada M, Morimoto S, Otsu K, Mortensen RM, Nakao K, Kimura T.
Circ Res., 130, 234-248, 2022

Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart.
Kawagishi H, Nakada T, Numaga-Tomita T, Larranaga M, Guo A, Song LS, Yamada M.
Am J Physiol Heart Circ Physiol., 323, H103-H120, 2022

Adrenomedullin-RAMP2 and -RAMP3 Systems Regulate Cardiac Homeostasis during Cardiovascular Stress.
Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Tanaka M, Wei Y, Kakihara S, Zhao Y, Aruga K, Kawagishi H, Nakada T, Yamada M, Shindo T.
Endocrinology, 162, bqab001, 2021

Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo.
Ichimura H, Kadota S, Kashihara T, Yamada M, Ito K, Kobayashi H, Tanaka Y, Shiba N, Chuma S, Tohyama S, Seto T, Okada K, Kuwahara K, Shiba Y.
Sci Rep., 10, 11883, 2020

Beta-Arrestin-Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate.
Kashihara T, Kawagishi H, Nakada T, Numaga-Tomita T, Kadota S, Wolf EE, Du CK, Shiba Y, Morimoto S, Yamada M.
JACC Basic Transl Sci, 5, 1057-1069, 2020

Effects of hypertension and antihypertensive treatments on sulfatide levels in serum and its metabolism.
Guo R, Hu X, Yamada Y, Harada M, Nakajima T, Kashihara T, Yamada M, Aoyama T, Kamijo Y.
Hypertens Res, 42, 598-609, 2019

Impact of chronic kidney dysfunction on serum Sulfatides and its metabolic pathway in mice.
Yamada Y, Harada M, Hashimoto K, Guo R, Nakajima T, Kashihara T, Yamada M, Aoyama T, Kamijo Y.
Glycoconj J., 36, 1-11, 2019

Prostanoid EP4 Receptor-Mediated Augmentation of Ih Currents in A beta Dorsal Root Ganglion Neurons Underlies Neuropathic Pain.
Zhang H, Kashihara T, Nakada T, Tanaka S, Ishida K, Fuseya S, Kawagishi H, Kiyosawa K, Kawamata M, Yamada M.
J Pharmacol Exp Ther., 368, 50-58, 2019

Increase in phospholamban content in mouse skeletal muscle after denervation.
Komatsu M, Nakada T, Kawagishi H, Kato H, Yamada M.
J Muscle Res Cell Motil., 39, 163-173, 2018

PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length CaV1.2 C-terminus.
Guo X, Kashihara T, Nakada T, Aoyama T, Yamada M.
Pflugers Arch., 470, 909-921, 2018

Sonic hedgehog signaling regulates the mammalian cardiac regenerative response.
Kawagishi H, Xiong J, Rovira, II, Pan H, Yan Y, Fleischmann BK, Yamada M, Finkel T.
J Mol Cell Cardiol., 123, 180-184, 2018

Physical interaction of junctophilin and the CaV1.1 C terminus is crucial for skeletal muscle contraction.
Nakada T, Kashihara T, Komatsu M, Kojima K, Takeshita T, Yamada M.
Proc Natl Acad Sci U S A., 115, 4507-4512, 2018

Angiotensin II activates CaV1.2 Ca2+ channels through beta-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes.
Kashihara T, Nakada T, Kojima K, Takeshita T, Yamada M.
J Physiol. (Lond.), 595, 4207-4225, 2017

Transplantation of adipose tissue-derived stem cells improves cardiac contractile function and electrical stability in a rat myocardial infarction model.
Gautam M, Fujita D, Kimura K, Ichikawa H, Izawa A, Hirose M, Kashihara T, Yamada M, Takahashi M, Ikeda U, Shiba Y.
J Mol Cell Cardiol., 81, 139-149, 2015

TRPM4 Channels Mediate Hypertonicity-induced, Ca2+-impermeable, Non-selective Cation Currents in a Cervical Cancer Cell Line, HeLa Cells.
Gomi S, Nakada T, Kashihara T, Ikeda U, Yamada M.
Shinshu Med J., 62, 33-44, 2014

Phlorizin prevents electrically-induced ventricular tachyarrhythmia during ischemia in Langendorff-perfused guinea-pig hearts.
Hirose M, Shibazaki T, Nakada T, Kashihara T, Yano S, Okamoto Y, Isaji M, Matsushita N, Taira E, Yamada M.
Biol Pharm Bull., 37, 1168-1176, 2014

Cardiac overexpression of constitutively active Galpha q Causes angiotensin II type1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice.
Matsushita N, Kashihara T, Shimojo H, Suzuki S, Nakada T, Takeishi Y, Mende U, Taira E, Yamada M, Sanbe A, Hirose M.
PLoS One., 9, e106354, 2014

Beta2-Adrenergic and M2-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure.
Kashihara T, Hirose M, Shimojo H, Nakada T, Gomi S, Hongo M, Yamada M.
Eur J Pharmacol., 724, 122-131, 2014

Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system.
Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T.
Hypertension., 6, 341-351, 2013

Nicorandil prevents Galphaq-induced progressive heart failure and ventricular arrhythmias in transgenic mice.
Hirose M, Takeishi Y, Nakada T, Shimojo H, Kashihara T, Nishio A, Suzuki S, Mende U, Matsumoto K, Matsushita N, Taira E, Sato F, Yamada M.
PLoS One., 7, e52667, 2012

KGA-2727, a novel selective inhibitor of a high-affinity sodium glucose cotransporter (SGLT1), exhibits antidiabetic efficacy in rodent models.
Shibazaki T, Tomae M, Ishikawa-Takemura Y, Fushimi N, Itoh F, Yamada M, Isaji M.
J Pharmacol Exp Ther., 342, 288-296, 2012

Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca2+ channel activity through phosphatases in heart failure.
Kashihara T, Nakada T, Shimojo H, Horiuchi-Hirose M, Gomi S, Shibazaki T, Sheng X, Hirose M, Hongo M, Yamada M.
Am J Physiol Heart Circ Physiol., 302, H1645-H1654, 2012

The proximal C-terminus of 1C subunits is necessary for junctional membrane targeting of cardiac L-type calcium channels.
Nakada T, Flucher BE, Kashihara T, Sheng X, Shibazaki T, Horiuchi-Hirose M, Gomi S, Hirose M, Yamada M.
Biochem J., 448, 221-231, 2012

Two mechanistically distinct effects of dihydropyridine nifedipine on CaV1.2 L-type Ca2+ channels revealed by Timothy syndrome mutation.
Sheng X, Nakada T, Kobayashi M, Kashihara T, Shibazaki T, Horiuchi-Hirose M, Gomi S, Hirose M, Aoyama T, Yamada M.
Eur J Pharmacol., 685, 15-23, 2012

Diacylglycerol kinase zeta inhibits ventricular tachyarrhythmias in a mouse model of heart failure.
Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, Kashihara T, Horiuchi-Hirose M, Kubota I, Mende U, Yamada M.
Circ J., 75, 2333-2342, 2011

Thrombin activates Ca2+-permeating nonselective cation channels through protein kinase C in human umbilical vein endothelial cells.
Tsujino N, Nakada T, Tsubouchi K, Kobayashi M, Kawai Y, Yano S, Matsunaga T, Hirose M, Ohmori S, Ohhashi T, Yamada M.
Shinshu Med J., 59, 13-26, 2011

Nicorandil ameliorates impulse conduction disturbances during ischemia in isolated arterially perfused canine atria.
Hirose M, Yano S, Nakada T, Horiuchi-Hirose M, Tsujino N, Yamada M.
Int J Cardiol., 146, 37-43, 2011

Acid-sensing ion channels in blood volume regulation.
Yamada M.
Circ J., 75, 781-782, 2011

Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes.
Horiuchi-Hirose M, Kashihara T, Nakada T, Kurebayashi N, Shimojo H, Shibazaki T, Sheng X, Yano S, Hirose M, Hongo M, Sakurai T, Moriizumi T, Ueda H, Yamada M.
Am J Physiol Heart Circ Physiol., 300, H978-H988, 2011

Selective alpha1A-adrenoceptor stimulation induces Mueller's smooth muscle contraction in an isolated canine upper eyelid preparation.
Yano S, Hirose M, Nakada T, Nakayama J, Matsuo K, Yamada M.
Curr Eye Res, 35, 363-369, 2010

Mitochondrial ATP-sensitive K+ channels, protectors of the heart.
Yamada M.
J Physiol. (Lond.), 588, 283-286, 2010

Diacylglycerol kinase zeta inhibits Galphsq-induced atrial remodeling in transgenic mice.
Hirose M, Takeishi Y, Niizeki T, Shimojo H, Nakada T, Kubota I, Nakayama J, Mende U, Yamada M.
Heart Rhythm., 6, 78-84, 2009

Effects of hormone-sensitive lipase disruption on cardiac energy metabolism in response to fasting and refeeding.
Suzuki J, Ueno M, Uno M, Hirose Y, Zenimaru Y, Takahashi S, Osuga J, Ishibashi S, Takahashi M, Hirose M, Yamada M, Kraemer FB, Miyamori I.
Am J Physiol Endocrinol Metab., 297, E1115-E1124, 2009

Mechanisms of preventive effect of nicorandil on ischaemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular wedges.
Hirose M, Tsujino N, Nakada T, Yano S, Imamura H, Yamada M.
Basic Clin Pharmacol Toxicol., 102, 504-514, 2008

MCP-1 induces cardioprotection against ischaemia/reperfusion injury: role of reactive oxygen species.
Morimoto H, Hirose M, Takahashi M, Kawaguchi M, Ise H, Kolattukudy PE, Yamada M, Ikeda U.
Cardiovasc Res., 78, 554-562, 2008

Contribution of L-type Ca2+ channels to early afterdepolarizations induced by I Kr and I Ks channel suppression in guinea pig ventricular myocytes.
Yamada M, Ohta K, Niwa A, Tsujino N, Nakada T, Hirose M.
J Membr Biol., 222, 151-166, 2008

Mutational analysis of block and facilitation of HERG current by a class III anti-arrhythmic agent, nifekalant.
Hosaka Y, Iwata M, Kamiya N, Yamada M, Kinoshita K, Fukunishi Y, Tsujimae K, Hibino H, Aizawa Y, Inanobe A, Nakamura H, Kurachi Y.
Channels (Austin)., 1, 198-208, 2007

Mechanisms of the preventive effect of pilsicainide on atrial fibrillation originating from the pulmonary vein.
Hirose M, Ohkubo Y, Takano M, Hamazaki M, Sekido T, Yamada M.
Circ J., 71, 1805-1814, 2007

Phosphatidylinositol 3,4,5-trisphosphate and Ca2+/calmodulin competitively bind to the regulators of G-protein-signalling (RGS) domain of RGS4 and reciprocally regulate its action.
Ishii M, Fujita S, Yamada M, Hosaka Y, Kurachi Y.
Biochem J., 385, 65-73, 2005

A functional role of the C-terminal 42 amino acids of SUR2A and SUR2B in the physiology and pharmacology of cardiovascular ATP-sensitive K+ channels.
Yamada M, Kurachi Y.
J Mol Cell Cardiol., 39, 1-6, 2005

Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes.
Hibino H, Fujita A, Iwai K, Yamada M, Kurachi Y.
J Biol Chem., 279, 44065-44073, 2004

Comparison of kinetic properties of quinidine and dofetilide block of HERG channels.
Tsujimae K, Suzuki S, Yamada M, Kurachi Y.
Eur J Pharmacol., 493, 29-40, 2004

Mutation in nucleotide-binding domains of sulfonylurea receptor 2 evokes Na-ATP-dependent activation of ATP-sensitive K+ channels: implication for dimerization of nucleotide-binding domains to induce channel opening.
Yamada M, Ishii M, Hibino H, Kurachi Y.
Mol Pharmacol., 66, 807-816, 2004

The nucleotide-binding domains of sulfonylurea receptor 2A and 2B play different functional roles in nicorandil-induced activation of ATP-sensitive K+ channels.
Yamada M, Kurachi Y.
Mol Pharmacol., 65, 1198-11207, 2004

Nateglinide, a D-phenylalanine derivative lacking either a sulfonylurea or benzamido moiety, specifically inhibits pancreatic beta-cell-type KATP channels.
Chachin M, Yamada M, Fujita A, Matsuoka T, Matsushita K, Kurachi Y.
J Pharmacol Exp Ther., 304, 1025-1032, 2003

The role of muscarinic K+ channels in the negative chronotropic effect of a muscarinic agonist.
Yamada M.
J Pharmacol Exp Ther., 300, 681-687, 2002

Beta-adrenergic modulation of prepulse facilitation of L-type calcium channels in rabbit ventricular myocytes.
Yamada M.
Pflugers Arch., 444, 89-98, 2002

The strongly inwardly rectifying background potassium channel (IK1) in cardiac myocytes is composed of Kir2.2 (IRK2): RT-PCR analysis of single cardiac myocyte mRNA.
Matsumoto Y, Isomoto S, Saito H, Inanobe A, Hibino H, Chachin M, Yamada M, Horio Y, Kurachi Y.
Med J Osaka Univ., 44, 15-22, 2001

Tertiapin potently and selectively blocks muscarinic K+ channels in rabbit cardiac myocytes.
Kitamura H, Yokoyama M, Akita H, Matsushita K, Kurachi Y, Yamada M.
J Pharmacol Exp Ther., 293, 196-205, 2000

Epinastine, a nonsedating histamine H1 receptor antagonist, has a negligible effect on HERG channel.
Chachin M, Katayama Y, Yamada M, Horio Y, Ohmura T, Kitagawa H, Uchida S, Kurachi Y.
Eur J Pharmacol., 374, 457-460, 1999

Chimeras of Kir6.1 and Kir6.2 reveal structural elements involved in spontaneous opening and unitary conductance of the ATP-sensitive K+ channels.
Kondo C, Repunte VP, Satoh E, Yamada M, Horio Y, Matsuzawa Y, Pott L, Kurachi Y.
Recept Channels., 6, 129-140, 1998

Identification and functional analysis of sulfonylurea receptor 1 variants in Japanese patients with NIDDM.
Ohta Y, Tanizawa Y, Inoue H, Hosaka T, Ueda K, Matsutani A, Repunte VP, Yamada M, Kurachi Y, Bryan J, Aguilar-Bryan L, Permutt MA, Oka Y.
Diabetes., 47, 476-481, 1998

The effects of nucleotides and potassium channel openers on the SUR2A/Kir6.2 complex K+ channel expressed in a mammalian cell line, HEK293T cells.
Okuyama Y, Yamada M, Kondo C, Satoh E, Isomoto S, Shindo T, Horio Y, Kitakaze M, Hori M, Kurachi Y.
Pflugers Arch., 435, 595-603, 1998

Intracellular nucleotide-mediated gating of SUR/Kir6.0 complex potassium channels expressed in a mammalian cell line and its modification by pinacidil.
Satoh E, Yamada M, Kondo C, Repunte VP, Horio Y, Iijima T, Kurachi Y.
J Physiol. (Lond.), 511, 663-674, 1998

SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil.
Shindo T, Yamada M, Isomoto S, Horio Y, Kurachi Y.
Br J Pharmacol., 124, 985-991, 1998

G protein regulation of potassium ion channels.
Yamada M, Inanobe A, Kurachi Y.
Pharmacol Rev., 50, 723-760, 1998

Clustering and enhanced activity of an inwardly rectifying potassium channel, Kir4.1, by an anchoring protein, PSD-95/SAP90.
Horio Y, Hibino H, Inanobe A, Yamada M, Ishii M, Tada Y, Satoh E, Hata Y, Takai Y, Kurachi Y.
J Biol Chem., 272, 12885-12888, 1997

Expression and clustered distribution of an inwardly rectifying potassium channel, KAB-2/Kir4.1, on mammalian retinal Muller cell membrane: their regulation by insulin and laminin signals.
Ishii M, Horio Y, Tada Y, Hibino H, Inanobe A, Ito M, Yamada M, Gotow T, Uchiyama Y, Kurachi Y.
J Neurosci., 17, 7725-7735, 1997

Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.
Yamada M, Isomoto S, Matsumoto S, Kondo C, Shindo T, Horio Y, Kurachi Y.
J Physiol. (Lond.), 499, 715-720, 1997

An ATP-dependent inwardly rectifying potassium channel, KAB-2 (Kir4. 1), in cochlear stria vascularis of inner ear: its specific subcellular localization and correlation with the formation of endocochlear potential.
Hibino H, Horio Y, Inanobe A, Doi K, Ito M, Yamada M, Gotow T, Uchiyama Y, Kawamura M, Kubo T, Kurachi Y.
J Neurosci., 17, 4711-4721, 1997

Sur2 and Kcnj8 genes are tightly linked on the distal region of mouse chromosome 6.
Isomoto S, Horio Y, Matsumoto S, Kondo C, Yamada M, Gilbert DJ, Copeland NG, Jenkins NA, Kurachi Y.
Mamm Genome., 8, 790-791, 1997

Molecular aspects of ATP-sensitive K+ channels in the cardiovascular system.
Isomoto S, Yamada M, Horio Y, Kurachi Y.
Jpn J Physiol., 47 Suppl., S4-S6, 1997

A functional model for G protein activation of the muscarinic K+ channel in guinea pig atrial myocytes. Spectral analysis of the effect of GTP on single-channel kinetics.
Hosoya Y, Yamada M, Ito H, Kurachi Y.
J Gen Physiol., 108, 485-495, 1996

A novel ubiquitously distributed isoform of GIRK2 (GIRK2B) enhances GIRK1 expression of the G-protein-gated K+ current in Xenopus oocytes.
Isomoto S, Kondo C, Takahashi N, Matsumoto S, Yamada M, Takumi T, Horio Y, Kurachi Y.
Biochem Biophys Res Commun., 218, 286-291, 1996

A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel.
Isomoto S, Kondo C, Yamada M, Matsumoto S, Higashiguchi O, Horio Y, Matsuzawa Y, Kurachi Y.
J Biol Chem., 271, 24621-24324, 1996

Cloning and functional expression of a novel isoform of ROMK inwardly rectifying ATP-dependent K+ channel, ROMK6 (Kir1.1f).
Kondo C, Isomoto S, Matsumoto S, Yamada M, Horio Y, Yamashita S, Takemura-Kameda K, Matsuzawa Y, Kurachi Y.
FEBS Lett., 399, 122-126, 1996

Competition between Mg2+ and spermine for a cloned IRK2 channel expressed in a human cell line.
Yamashita T, Horio Y, Yamada M, Takahashi N, Kondo C, Kurachi Y.
J Physiol. (Lond.), 493, 143-156, 1996

Specialized release zones in chromaffin cells examined with pulsed-laser imaging.
Robinson IM, Yamada M, Carrion-Vazquez M, Lennon VA, Fernandez JM.
Cell Calcium., 20, 181-201, 1996

Gbg directly binds to the carboxyl terminus of the G protein-gated muscarinic K+ channel, GIRK1
Inanobe A, Morishige KI, Takahashi N, Ito H, Yamada M, Takumi T, Nishina H, Takahashi K, Kanaho Y, Katada T, et al.
Biochem Biophys Res Commun., 212, 1022-1028, 1995

Molecular and functional heterogeneity of inward rectifier potassium channels in brain and heart.
Takahashi N, Morishige K-I, Yamada M, Takumi T, Kurachi Y.
Heart Vessels., Supple. 9, 8-11, 1995

A novel ATP-dependent inward rectifier potassium channel expressed predominantly in glial cells.
Takumi T, Ishii T, Horio Y, Morishige K, Takahashi N, Yamada M, Yamashita T, Kiyama H, Sohmiya K, Nakanishi S, et al.
J Biol Chem., 270, 16339-16346, 1995

Spermine gates inward-rectifying muscarinic but not ATP-sensitive K+ channels in rabbit atrial myocytes. Intracellular substance-mediated mechanism of inward rectification.
Yamada M, Kurachi Y.
J Biol Chem., 270, 9289-9294, 1995

Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain.
Takahashi N, Morishige K, Jahangir A, Yamada M, Findlay I, Koyama H, Kurachi Y.
J Biol Chem., 269, 23274-23279, 1994

Muscarinic K+ channels are activated by beta gamma subunits and inhibited by the GDP-bound form of alpha subunit of transducin.
Yamada M, Ho YK, Lee RH, Kontanill K, Takahashill K, Katadall T, Kurachi Y.
Biochem Biophys Res Commun., 200, 1484-1490, 1994

Regulation of potassium channels by G-protein subunits and arachidonic acid metabolites.
Yamada M, Terzic A, Kurachi Y.
Methods Enzymol., 238, 394-422, 1994

Molecular cloning and functional expression of a novel brain-specific inward rectifier potassium channel.
Morishige K, Takahashi N, Jahangir A, Yamada M, Koyama H, Zanelli JS, Kurachi Y.
FEBS Lett., 346, 251-256, 1994

GK* and brain Gbg activate muscarinic K+ channel through the same mechanism.
Yamada M, Jahangir A, Hosoya Y, Inanobe A, Katada T, Kurachi Y.
J Biol Chem., 268, 24551-24554, 1993

YM934, a novel K+ channel opener, activates ATP-sensitive K+ channels in cardiac myocytes.
Yamada M, Terzic A, Findlay I, Jahangir A, Shen WK, Kurachi Y.
J Pharmacol Exp Ther., 267, 1544-1549, 1993

Cardiovascular profile of E4080 and its analogue ER001533: Novel potassium channel openers with bradycardiac properties.
Terzic A, Tung RT, Shen WK, Yamada M, Kurachi Y.
Drug Rev., 11, 223-233, 1993

P2-purinoceptor activation stimulates phosphoinositide hydrolysis and inhibits accumulation of cAMP in cultured ventricular myocytes.
Yamada M, Hamamori Y, Akita H, Yokoyama M.
Circ Res., 70, 477-485, 1992

Lysophosphatidylcholine inhibits bradykinin-induced phosphoinositide hydrolysis and calcium transients in cultured bovine aortic endothelial cells.
Inoue N, Hirata K, Yamada M, Hamamori Y, Matsuda Y, Akita H, Yokoyama M.
Circ Res., 71, 1410-1421, 1992

5-Hydroxytryptamine induces phospholipase C-mediated hydrolysis of phosphoinositides through 5-hydroxytryptamine-2 receptors in cultured fetal mouse ventricular myocytes.
Hamamori Y, Yokoyama M, Yamada M, Akita Makin, Goshima K, Fukuzaki H.
Circ Res., 66, 1474-1483, 1990

熱血　循環器学　洋學社　井上信孝編集
山田充彦, 新しい小児心不全治療薬の開発をめざして
洋學社, 1-15 2019

倉智　嘉久編：別冊・医学のあゆみイオンチャネル最前線update
山田充彦, ヌクレオチドと薬物による心血管系ATP感受性K+チャネル活性化の分子機構
医歯薬出版株式会社，東京, pp 101-107 2005

神経障害性疼痛へのHCN チャネルの関与
山田充彦、張昊、柏原俊英、中田勉、田中聡、石田公美子、布施谷仁志、川岸裕幸、中村博之、清沢研一、川真田樹人
第100回日本生理学会大会, 15 Mar. 2023

心不全治療薬としてのレニン・アンジオテンシン・アルドステロン系抑制薬：その薬理と臨床（基礎編）
山田充彦
第96回日本薬理学会年会, 03 Dec. 2022, Invited

Molecular Mechanism underlying Initiation ＆ Maturation of Heartbeat
Mitsuhiko Yamada, Tomoe Nakamura-Nishitani
第99回日本生理学会大会, 17 Mar. 2022

低分子βアレスチンバイアスAT1受容体アゴニストの開発
山田充彦、小松弘嗣
第95回日本薬理学会年会, 07 Mar. 2022

T1アンジオテンシン受容体を利用した新たな胎児・新生児心不全治療法の開発
山田充彦
日本胎児心臓病学会第28回学術集会, 18 Feb. 2022, Invited

Cardiac AT Receptor/β-Arrestin Pathway is a Neonatal-Specific Druggable Target for Pediatric Heart Failure
Mitsuhiko Yamada, Hiroyuki Kawagishi, Shin Kadota, Yuji Shiba, Sachio Morimoto
Experimental Biology 2021, 27 Apr. 2021

Cardiac AT1 receptor/-arrestin pathway is a neonatal-specific druggable target for pediatric heart failure.
Mitsuhiko Yamada
CVMV2021, 12 Mar. 2021

Cardiac AT1 receptor/-arrestin axis is a novel druggable target for pediatric heart failure
Mitsuhiko Yamada, Hiroyuki Kawagishi, Shin Kadota, Cheng-Kun Du, Yuji Shiba, Sachio Morimoto
The 12th Annual Meeting of Japanese Safety Pharmacology Society, 12 Mar. 2021, Invited

小児疾患治療薬の新たな薬物標的の探索
山田充彦
第94回日本薬理学会年会, 09 Mar. 2021

Postnatal loss of gp130 caused impaired cardiac contractility accompanied by inhibition of physiological proliferation of cardiomyocytes.
Hiroyuki Kawagishi, Tsutomu Nakada, Takuro Numaga-Tomita, Mitsuhiko Yamada
NIPS International Meeting on Cardiovascular Physiology 2020, 25 Dec. 2020

小児心不全では、AT1アンジオテンシン受容体を抑制すべきか刺激すべきか？
山田充彦
第56回日本小児循環器学会総会・学術集会, 24 Nov. 2020

Molecular mechanism underlying cardiac early afterdepolarization induced by IKr and IKs suppression.
Yamada, M.
The 11th Annual Meeting of Japanese Safety Pharmacology Society, 28 Feb. 2020, Invited

新生児マウスにおける、gp130受容体を介した心筋細胞の発達機構
川岸裕幸、Maite LARRA AGA、冨田（沼賀）拓郎、中田勉、山田充彦
筋生理の集い, 21 Dec. 2019

A beta arrestin-bias AT1 receptor agonist improves the survival of neonatal knock-in mice bearing a human dilated cardiomyopathy mutation.
Yamada, M.
The 50th NIPS International Symposium. ‘MIRACLES’ in Cardiovascular Physiology, 04 Dec. 2019

βアレスチンバイアスアンジオテンシン1型受容体アゴニストは、新生児マウス心臓において持続的な陽性変力作用を示す
川岸裕幸、柏原俊英、中田勉、冨田拓郎、山田充彦
第29回日本循環薬理学会, 29 Nov. 2019

心室筋活動電位内でのL型Ca2+電流波形を決定する分子機構の検討
山田充彦、西村仁志、柏原俊英
学術セミナー「分子から個体へ：俯瞰と接近の生命科学」, 18 Oct. 2019

Molecular mechanisms underlying the agonistic effect of FPL64176 on CaV1.2 Ca2+ channels
冨田拓郎、五味志文、柏原俊英、中田勉、山田充彦
第141回日本薬理学会関東部会, 12 Oct. 2019

除神経モデルマウスの骨格筋におけるホスホランバンの発現量の増加
中田勉、小松雅俊、山田充彦
第66回中部日本生理学会, 04 Oct. 2019

小胞体CaセンサーSTIM1によるCav1.2チャネル制御機構の解明
冨田拓郎、高橋弘毅、山田充彦
第66回中部日本生理学会, 04 Oct. 2019

マウス心筋細胞の生下後の機能的最終分化のメカニズムの解析
川岸裕幸、中田勉、山田充彦
第140回日本薬理学会関東部会, 06 Jul. 2019

Interaction of junctophilins and the CaV1.1 is essential for the skeletal muscle contraction.
Nakada, T., Kashihara, T., Komatsu, M., Yamada, M.
FAOPS 2019, 29 Mar. 2019

EP4 receptor-mediated augmentation of Ih currents in A DRG neurons underlies neuropathic pain.
Yamada, M., Zhang, H., Kashihara, T., Nakada, T., Tanaka, S., Ishida, K., Fuseya, S., Kawagishi, H., Kiyosawa, K., Kawamata, M.
FAOPS 2019, 29 Mar. 2019

マウス個体を用いた心筋細胞成熟化因子の同定
川岸裕幸、中田勉、山田充彦
第92回日本薬理学会年会, 16 Mar. 2019

プロスタノイドEP4受容体を介する後根神経節A細胞のIh電流増強による神経障害性疼痛の発症
山田充彦、張昊、柏原俊英、中田勉、田中聡、石田公美子、布施谷仁志、川岸裕幸、清沢研吉、川眞田樹人
第92回日本薬理学会年会, 15 Mar. 2019

c-Srcによる全長型CaV1.2サブユニットを有するL型Ca2+チャネルの活性を介したPDGFによる増殖型血管平滑筋細胞の遊走
中田勉、郭暁光、柏原俊英、青山俊文、山田充彦
第92回日本薬理学会年会, 15 Mar. 2019

Molecular mechanisms underlying spatiotemporal regulation of L-type Ca2+ channels in muscles. Logic of life: ion channel structure, function and physiology.
Yamada, M.
International commemorative symposium in celebration of retirement of Professor Yoshihisa Kurachi, 13 Mar. 2019

G蛋白サブユニットGαoのCa2+handling恒常性および心収縮能維持における意義の解明
稲住 英明, 桑原 宏一郎, 桑原 佳宏, 中川 靖章, 木下 秀之, 錦見 俊雄, 呉林 なごみ, 山田 充彦, 柏原 俊英, 中尾 一和, 木村 剛
日本臨床分子医学会学術総会プログラム・抄録集 55回 51, Apr. 2018

HFpEFにおける心筋興奮収縮連関の変化
山田 充彦, Kashihara Toshihide
日本循環器学会学術集会抄録集 81回 TP7-4, Mar. 2017

Pharmacology
Shinshu University

Pharmacology
Shinshu University

器官・組織・細胞機能研究方法特論
Shinshu University

The American Physiological Society

Physiological Society of Japan

The Japanese Circulation Society

The Japanese Society of Electrocardiology

Biophysical Society

Application of a beta-arrestin-biased agonist, TRV027 to pediatric heart failure
共同研究, Trevena Inc.
26 Jul. 2021

生下後の心筋分化誘導因子の同定：インビトロ心筋最終分化誘導法の開発
科学研究費補助金, 基盤研究(C)
01 Apr. 2018 - 31 Mar. 2020

AT1アンジオテンシン受容体βアレスチンバイアスアゴニストが若年性心不全に与える効果の検討
ファイザー株式会社
2018

サルコペニアにおいて筋⼒低下が⽣じるメカニズムの解明
MSD株式会社
2018

βアレスチンバイアスAT1受容体アゴニストを⽤いた⼩児⼼不全治療法の開発
塩野義製薬
2018

⼩児⼼不全の新しい薬物療法の開発
第一三共株式会社
2018

⼩児⼼不全の新しい治療法の開発
アステラス製薬
2018

βアレスチンバイアスAT1受容体アゴニストを⽤いた⼩児⼼不全治療法の開発
バイエル薬品株式会社
2018

⼩児⼼不全の新しい治療法の開発
ブリストル・マイヤーズ　スクイブ株式会社
2018

βアレスチンバイアスAT1受容体アゴニストを⽤いた⼩児⼼不全治療法の開発
バイエル薬品株式会社
2017

⼩児⼼不全の新しい薬物療法の開発
第一三共株式会社
2017

AT1アンジオテンシン受容体βアレスチンバイアスアゴニストが若年性心不全に与える効果の検討
ファイザー株式会社
2017

βアレスチンバイアスAT1受容体アゴニストを⽤いた⼩児⼼不全治療法の開発
塩野義製薬
2017

βアレスチンバイアスAT1受容体アゴニストを⽤いた⼩児⼼不全治療法の開発
武田薬品工業株式会社
2017

AT1アンジオテンシン受容体βアレスチンバイアスアゴニストが若年性心不全に与える効果の検討
ファイザー株式会社
2016

心不全の心室筋細胞でのL型Ca2+チャネルのリモデリングに関する研究
アステラス製薬
2016

L型カルシウムチャネル阻害薬の開口状態親和性の定量的解析と阻害薬作用のモデル化
科学研究費補助金, 基盤研究（Ｃ）
2009 - 2011

Gqマウス心不全モデルを用いたニコランジルの心筋繊維化への抑制効果
受託研究, 中外製薬(株）
2008 - 2009

新規Caチャネル阻害薬を用いた、がん細胞の増殖抑制法の研究
受託研究, 小野薬品工業(株）
2008 - 2009

イオンチャネルとトランスポーターのクロストークに関するｋｒん旧
受託研究, キッセイ薬品工業(株）
2007 - 2009

虚血による貫壁性活動電位幅不均一性に対するNicorandilの抑制効果
受託研究, 中外製薬(株）
2007 - 2008

新規Caチャネル阻害薬を用いた、がん細胞の増殖抑制法の研究
受託研究, 小野薬品工業(株）
2007 - 2008

イヌ虚血心室筋の頻拍性不整脈発生に対するニコランジルの保護効果
受託研究, 中外製薬(株）
2006 - 2007

新規Caチャネル阻害薬を用いた、がん細胞の増殖抑制法の研究
受託研究, 小野薬品工業(株）
2006 - 2007

虚血による貫壁性活動電位幅不均一性に対するNicorandilの抑制効果
受託研究, 中外製薬(株）
2005 - 2006

薬物によるＡＴＰ感受性Ｋ＋チャネルの活性調節機構の立体構造基盤の解明
科学研究費補助金, 基盤研究（Ｃ）
2004 - 2006

薬物によるATP感受性K+チャネルの活性調節機構の立体構造基盤の解明
科学研究費補助金, 基盤研究（Ｃ）
2004 - 2006

副交感性心拍調節におけるムスカリン性Ｋチャネルの役割の検討
科学研究費補助金, 基盤研究（Ｃ）
2000 - 2002

心筋細胞の再生療法に関する研究：心筋細胞の電気生理学的分化とその制御因子の同定
2000 - 2002

カルシウムチャネルによる心・血管細胞収縮調節機構とその異常
1999 - 2001

動脈硬化血管の収縮異常と血管平滑筋型ATP感受性K+チャネル
科学研究費補助金, 特定領域研究Ａ
1997 - 1998

内向き整流カリウムチャネルのポリアミン受容体の解析と新しい潜在的薬物作用点の検討
科学研究費補助金, 一般研究Ｂ
1996 - 1997

内向き整流カリウムチャネルの細胞内物質によるゲーテイング
科学研究費補助金, 奨励研究Ａ
1995 - 1995

Physiological, pathophysiological and pharmacological analyses of cardiac L-type Ca2+ channels

Development of therapeutics for pediatric heart failure

Investigation of the mechanism underlying metanephrogenesis

市民公開講座：心不全の予防・診療・リハビリテーションの最前線
オンライン, 25 Oct. 2020 - 25 Oct. 2020

ペプチドで小児心不全治療 小児用創薬のヒントに
日本経済新聞, 07 Dec. 2020

新生児や乳児の心臓 収縮力を高める仕組み解明
信濃毎日新聞, 30 Nov. 2020

生理研研究会「心血管研究会」
Planning etc
松本, 13 Oct. 2022 - 14 Oct. 2022

Planning etc
生理研研究会「心血管研究会」, オンライン, 18 Nov. 2021 - 19 Nov. 2021

Planning etc
第143回日本薬理学会関東部会, オンライン, 24 Oct. 2020 - 24 Oct. 2020

Planning etc
第26回日本循環薬理学会, 信州大学医学部附属病院外来棟　大会議室他, 02 Dec. 2016 - 02 Dec. 2016