
NOMURA Wataru
Faculty of Agriculture Department of Agricultural and Life Sciences Division of Life and Food Science
Assistant Professor
Researcher Information
Field Of Study
Career
Educational Background
Research activity information
Paper
- Metabolome analysis reveals that cyclic adenosine diphosphate ribose contributes to the regulation of differentiation in mice adipocyte.
Haruya Takahashi; Kento Nishitani; Satoko Kawarasaki; Agustin Martin-Morales; Hiroyuki Nagai; Hidetoshi Kuwata; Motohiro Tokura; Haruka Okaze; Shinsuke Mohri; Takeshi Ara; Tetsuro Ito; Wataru Nomura; Huei-Fen Jheng; Teruo Kawada; Kazuo Inoue; Tsuyoshi Goto
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 38(1), e23391, Jan. 2024, Refereed

- Activation of the DNA damage checkpoint perturbs asymmetric localization of Kar9 to spindle pole bodies in Saccharomyces cerevisiae.
#Momoko Hayashida; #Wataru Nomura; Atsushi Shiojiri; Yoshiharu Inoue
Biochemical and biophysical research communications, 685, 149157-149157, Oct. 2023, Refereed
Lead, Corresponding

- Combined treatment with teneligliptin and canagliflozin additively suppresses high-fat diet-induced body weight gain in mice with modulation of lipid metabolism-related gene expression.
Satoko Kawarasaki; Honami Sawazaki; Hiroaki Iijima; Haruya Takahashi; Wataru Nomura; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
European journal of pharmacology, 947, 175682-175682, May 2023, Refereed

- 8-Prenyl daidzein and 8-prenyl genistein from germinated soybean modulate inflammatory response in activated macrophages.
Huei-Fen Jheng; Miho Takase; Satoko Kawarasaki; Zheng Ni; Shinsuke Mohri; Kanako Hayashi; Atsushi Izumi; Kuni Sasaki; Yu Shinyama; Jungin Kwon; Su-Ping Ng; Haruya Takahashi; Wataru Nomura; Rina Yu; Koji Ochiai; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
Bioscience, biotechnology, and biochemistry, 87(7), 747-757, Apr. 2023, Refereed

- Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes.
Jungin Kwon; Yu-Sheng Yeh; Satoko Kawarasaki; Hiroto Minamino; Yoshihito Fujita; Yuko Okamatsu-Ogura; Haruya Takahashi; Wataru Nomura; Shigenobu Matsumura; Rina Yu; Kazuhiro Kimura; Masayuki Saito; Nobuya Inagaki; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
iScience, 26(3), 106161-106161, Mar. 2023, Refereed

- Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1-p38-mTORC1 signaling axis in adipocytes.
#Su-Ping Ng; #Wataru Nomura; Haruya Takahashi; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto; Yoshiharu Inoue
The Biochemical journal, 479(21), 2279-2296, Nov. 2022, Refereed
Lead, Corresponding

- Metabolomics reveals inosine 5'-monophosphate is increased during mice adipocyte browning.
Haruya Takahashi; Motohiro Tokura; Satoko Kawarasaki; Hiroyuki Nagai; Mari Iwase; Kento Nishitani; Haruka Okaze; Shinsuke Mohri; Tetsuro Ito; Takeshi Ara; Huei-Fen Jheng; Wataru Nomura; Teruo Kawada; Kazuo Inoue; Tsuyoshi Goto
The Journal of biological chemistry, 298(10), 102456-102456, Sep. 2022, Refereed

- Screening of flavor compounds using Ucp1-luciferase reporter beige adipocytes identified 5-methylquinoxaline as a novel UCP1-inducing compound.
Satoko Kawarasaki; Kazuki Matsuo; Hidetoshi Kuwata; Lanxi Zhou; Jungin Kwon; Zheng Ni; Haruya Takahashi; Wataru Nomura; Hisanori Kenmotsu; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
Bioscience, biotechnology, and biochemistry, 86(3), 380-389, Feb. 2022, Refereed

- Methylglyoxal attenuates isoproterenol-induced increase in uncoupling protein 1 expression through activation of JNK signaling pathway in beige adipocytes.
Su-Ping Ng; Wataru Nomura; Haruya Takahashi; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
Biochemistry and biophysics reports, 28, 101127-101127, Dec. 2021, Refereed
Corresponding

- Metabolome analysis revealed that soybean-Aspergillus oryzae interaction induced dynamic metabolic and daidzein prenylation changes.
Haruya Takahashi; Koji Ochiai; Kuni Sasaki; Atsushi Izumi; Yu Shinyama; Shinsuke Mohri; Wataru Nomura; Huei-Fen Jheng; Teruo Kawada; Kazuo Inoue; Tsuyoshi Goto
PloS one, 16(7), e0254190, 2021, Refereed

- Glycerol kinase stimulates uncoupling protein 1 expression by regulating fatty acid metabolism in beige adipocytes.
Mari Iwase; Soshi Tokiwa; Shigeto Seno; Takako Mukai; Yu-Sheng Yeh; Haruya Takahashi; Wataru Nomura; Huei-Fen Jheng; Sigenobu Matsumura; Tatsuya Kusudo; Naoki Osato; Hideo Matsuda; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
The Journal of biological chemistry, 295(20), 7033-7045, May 2020, Refereed

- Anti-Inflammatory and Antioxidative Properties of Isoflavones Provide Renal Protective Effects Distinct from Those of Dietary Soy Proteins against Diabetic Nephropathy.
Huei-Fen Jheng; Kanako Hayashi; Yasuki Matsumura; Teruo Kawada; Shigeto Seno; Hideo Matsuda; Kazuo Inoue; Wataru Nomura; Haruya Takahashi; Tsuyoshi Goto
Molecular nutrition & food research, 64(10), e2000015, May 2020, Refereed

- Long non-coding RNA 2310069B03Rik functions as a suppressor of Ucp1 expression under prolonged cold exposure in murine beige adipocytes.
Mari Iwase; Shoko Sakai; Shigeto Seno; Yu-Sheng Yeh; Tony Kuo; Haruya Takahashi; Wataru Nomura; Huei-Fen Jheng; Paul Horton; Naoki Osato; Hideo Matsuda; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
Bioscience, biotechnology, and biochemistry, 84(2), 305-313, Feb. 2020, Refereed

- Comparative Analysis of the Preventive Effects of Canagliflozin, a Sodium-Glucose Co-Transporter-2 Inhibitor, on Body Weight Gain Between Oral Gavage and Dietary Administration by Focusing on Fatty Acid Metabolism.
Satoko Kawarasaki; Honami Sawazaki; Hiroaki Iijima; Su-Ping Ng; Jungin Kwon; Shinsuke Mohri; Mari Iwase; Huei-Fen Jheng; Haruya Takahashi; Wataru Nomura; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
Diabetes, metabolic syndrome and obesity : targets and therapy, 13, 4353-4359, 2020, Refereed

- Soy hydrolysate enhances the isoproterenol-stimulated lipolytic pathway through an increase in β-adrenergic receptor expression in adipocytes.
Ng SP; Nomura W; Mohri S; Takahashi H; Jheng HF; Ara T; Nagai H; Ito T; Kawada T; Goto T
Bioscience, biotechnology, and biochemistry, 83(9), 1782-1789, Sep. 2019, Refereed
Corresponding

- A new mouse model for noninvasive fluorescence-based monitoring of mitochondrial UCP1 expression.
Kawarasaki S; Kuwata H; Sawazaki H; Sakamoto T; Nitta T; Kim CS; Jheng HF; Takahashi H; Nomura W; Ara T; Takahashi N; Tomita K; Yu R; Kawada T; Goto T
FEBS letters, 593(11), 1201-1212, Jun. 2019, Refereed

- Lactobacillus helveticus-MIKI-020 enhances hepatic FGF21 expression and decreases the core body temperature during sleep in mice
Kiriyama K; Goto T; Yamamoto H; Ara T; Takahashi H; Jheng HF; Nomura W; Inoue H; Nakata R; Kawada T
Journal of Functional Foods, 54, 529-535, Mar. 2019, Refereed - Endoplasmic Reticulum Stress Impaired Uncoupling Protein 1 Expression via the Suppression of Peroxisome Proliferator-Activated Receptor γ Binding Activity in Mice Beige Adipocytes.
Yuliana A; Daijo A; Jheng HF; Kwon J; Nomura W; Takahashi H; Ara T; Kawada T; Goto T
International journal of molecular sciences, 20(2), Jan. 2019, Refereed

- 10-Hydroxyoctadecanoic Acid from Lactobacillus amylovorus CP1563 Activates PPARalpha and Improves Dyslipidemia
Yumeko Aoki; Tomonori Sugawara; Sae Yanagihara; Haruya Takahashi; Wataru Nomura; Jheng Huei-Fen; Takeshi Ara; Tsuyoshi Goto; Teruo Kawada; Daisuke Sawada
Pharmacometrics, 95(3/4), 73-82, Nov. 2018, Refereed - The dipeptidyl peptidase-4 (DPP-4) inhibitor teneligliptin enhances brown adipose tissue function, thereby preventing obesity in mice.
Takeda K; Sawazaki H; Takahashi H; Yeh YS; Jheng HF; Nomura W; Ara T; Takahashi N; Seno S; Osato N; Matsuda H; Kawada T; Goto T
FEBS open bio, 8(11), 1782-1793, Nov. 2018, Refereed

- β-adrenergic Receptor Stimulation Revealed a Novel Regulatory Pathway via Suppressing Histone Deacetylase 3 to Induce Uncoupling Protein 1 Expression in Mice Beige Adipocyte.
Yuliana A; Jheng HF; Kawarasaki S; Nomura W; Takahashi H; Ara T; Kawada T; Goto T
International journal of molecular sciences, 19(8), Aug. 2018, Refereed

- Synthesized enone fatty acids resembling metabolites from gut microbiota suppress macrophage-mediated inflammation in adipocytes
Ha-Eun Yang; Yongjia Li; Akira Nishimura; Huei-Fen Jheng; Ana Yuliana; Ryuji Kitano-Ohue; Wataru Nomura; Nobuyuki Takahashi; Chu-Sook Kim; Rina Yu; Nahoko Kitamura; Si-Bum Park; Shigenobu Kishino; Jun Ogawa; Teruo Kawada; Tsuyoshi Goto
MOLECULAR NUTRITION & FOOD RESEARCH, 61(10), Oct. 2017, Refereed


- Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPAR gamma Activation
Mari Iwase; Takayuki Yamamoto; Kanako Nishimura; Haruya Takahashi; Shinsuke Mohri; Yongjia Li; Huei-Fen Jheng; Wataru Nomura; Nobuyuki Takahashi; Chu-Sook Kim; Rina Yu; Masahiko Taniguchi; Kimiye Baba; Shigeru Murakami; Teruo Kawada; Tsuyoshi Goto
LIPIDS, 52(7), 657-664, Jul. 2017, Refereed


- The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-alpha agonist-induced amelioration of metabolic disorders in obese mice
Tsuyoshi Goto; Mariko Hirata; Yumeko Aoki; Mari Iwase; Haruya Takahashi; Minji Kim; Yongjia Li; Huei-Fen Jheng; Wataru Nomura; Nobuyuki Takahashi; Chu-Sook Kim; Rina Yu; Shigeto Seno; Hideo Matsuda; Megumi Aizawa-Abe; Ken Ebihara; Nobuyuki Itoh; Teruo Kawada
JOURNAL OF BIOLOGICAL CHEMISTRY, 292(22), 9175-9190, Jun. 2017, Refereed


- 4-Hydroxyderricin, as a PPAR gamma Agonist, Promotes Adipogenesis, Adiponectin Secretion, and Glucose Uptake in 3T3-L1 Cells
Yongjia Li; Tsuyoshi Goto; Kanae Yamakuni; Haruya Takahashi; Nobuyuki Takahashi; Huei-Fen Jheng; Wataru Nomura; Masahiko Taniguchi; Kimiye Baba; Shigeru Murakami; Teruo Kawada
LIPIDS, 51(7), 787-795, Jul. 2016, Refereed


- 10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPAR gamma and stimulates adipogenesis
Tsuyoshi Goto; Young-Il Kim; Tomoya Furuzono; Nobuyuki Takahashi; Kanae Yamakuni; Ha-Eun Yang; Yongjia Li; Ryuji Ohue; Wataru Nomura; Tatsuya Sugawara; Rina Yu; Nahoko Kitamura; Si-Bum Park; Shigenobu Kishino; Jun Ogawa; Teruo Kawada
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 459(4), 597-603, Apr. 2015, Refereed


- 13-Oxo-9(Z),11(E),15(Z)-octadecatrienoic Acid Activates Peroxisome Proliferator-Activated Receptor gamma in Adipocytes
Haruya Takahashi; Hideyuki Hara; Tsuyoshi Goto; Kosuke Kamakari; Nomura Wataru; Shinsuke Mohri; Nobuyuki Takahashi; Hideyuki Suzuki; Daisuke Shibata; Teruo Kawada
LIPIDS, 50(1), 3-12, Jan. 2015, Refereed


- Role of Gcn4 for adaptation to methylglyoxal in Saccharomyces cerevisiae: Methylglyoxal attenuates protein synthesis through phosphorylation of eIF2 alpha
Wataru Nomura; Kazuhiro Maeta; Keiko Kita; Shingo Izawa; Yoshiharu Inoue
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 376(4), 738-742, Nov. 2008, Refereed
Lead


- Release of thioredoxin from Saccharomyces cerevisiae with environmental stimuli: solubilization of thioredoxin with ethanol
Yoko Takeuchi; Wataru Nomura; Takumi Ohdate; Shogo Tamasu; Hiroshi Masutani; Kazuo Murata; Shingo Izawa; Junji Yodoi; Yoshiharu Inoue
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 75(6), 1393-1399, Jul. 2007, Refereed


- Efficient extraction of thioreodoxin from Saccharomyces cerevisiae by ethanol
Yoshiharu Inoue; Wataru Nomura; Yoko Takeuchi; Takumi Ohdate; Shogo Tamasu; Atsushi Kitaoka; Yoshifumi Kiyokawa; Hiroshi Masutani; Kazuo Murata; Yoshinori Wakai; Shingo Izawa; Junji Yodoi
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 73(5), 1672-1675, Mar. 2007, Refereed


Books and other publications
- 脂肪酸および脂肪酸代謝物が褐色脂肪組織機能に及ぼす影響~ω-3脂肪酸を中心に~
後藤剛; 岩瀬麻里; 川原崎聡子; 高橋春弥; 野村亘; 井上和生; 河田照雄, Joint work
BIO INDUSTRY (シーエムシー出版), Oct. 2020脂肪組織機能を制御する食品由来成分に関する研究
岩瀬麻里; 川原崎聡子; 毛利晋輔; 高橋春弥; 野村亘; Huei-Fen Jheng; 井上和生; 河田照雄; 後藤剛, Joint work
日本機能性食品医用学会, 2020The Yeast Role in Medical Applications
Yoshiharu Inoue; Wataru Nomura, Contributor, TOR signaling in budding yeast
InTechOpen, Jan. 2018Lectures, oral presentations, etc.
- 酵母の細胞壁ストレスを感知するCWI経路は細胞膜健全性に寄与するTORC2シグナルを負に制御する
野村 亘; 井上善晴
第46回日本分子生物学会年会 シンポジウム, Dec. 2023膜ストレスを感知するTORシグナルの制御機構
野村 亘
生理化学研究ユニット第10回シンポジウム, Dec. 2020出芽酵母のストレス応答におけるPKCシグナルの制御機構
野村 亘
酵母研究会 第85回講演会, Jul. 2018酵母のストレス応答におけるPKCシグナル制御機構に関する研究
野村 亘
第65回 日本生化学会近畿支部例会 近畿支部奨励賞受賞記念講演, May 2018解糖系代謝物によるTORC2シグナルの活性化
野村 亘; 河田照雄; 井上善晴
第36回 日本分子生物学会年会 ワークショップ, Dec. 2013Courses
- 科学英語I
Apr. 2026 - Present - 食と微生物(分担)(信州大学)
Apr. 2025 - Present - 食と緑の科学特論(分担)(信州大学)
Apr. 2024 - Present - 食料資源利用学特論・食品バイオサイエンス特論(分担)(信州大学)
Apr. 2024 - Present - 分子生物・遺伝子工学特論(分担)(信州大学)
Apr. 2024 - Present - 応用微生物学特論(分担)(信州大学)
Apr. 2024 - Present - 微生物学系実験(分担)(信州大学)
Apr. 2024 - Present - 代謝生化学(分担)(信州大学)
Apr. 2024 - Present - 応用微生物学(分担)(信州大学)
Apr. 2024 - Present - 新入生ゼミナール(分担)(信州大学)
Apr. 2024 - Present - ニューバイオテクノロジー入門(分担)(信州大学)
Apr. 2024 - Present - 生物学系基礎実験(分担)(信州大学)
Apr. 2024 - Mar. 2026 - エネルギー変換細胞学専攻実験(京都大学)
Apr. 2021 - Mar. 2024 - エネルギー変換細胞学専攻演習(京都大学)
Apr. 2021 - Mar. 2024 - 生理化学概論(京都大学)
Apr. 2016 - Mar. 2024 - 生化学I(京都府立大学)
Apr. 2018 - Mar. 2023 - 代謝栄養学特論(京都大学)
Apr. 2017 - Mar. 2021 - 食品分子機能学専攻実験(京都大学)
Apr. 2016 - Mar. 2021 - 食品分子機能学専攻演習(京都大学)
Apr. 2016 - Mar. 2021 - 食品生化学実験および実験法(京都大学)
Apr. 2016 - Mar. 2021
Affiliated academic society
Research Themes
- 細胞膜動態を感知するTORC2シグナルの制御機構:2段階制御モデルの実証
科学研究費助成事業, 日本学術振興会, 基盤研究(C)
信州大学
01 Apr. 2025 - 31 Mar. 2028 - 酵母におけるプロテインキナーゼCによるTORC2シグナルの負の制御
科学研究費助成事業, 日本学術振興会, 基盤研究(C)
京都大学
01 Apr. 2022 - 31 Mar. 2025 - Study on the mechanism of action of plasma membrane lipids that contribute to the activation of TORC2 signaling
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Kyoto University
01 Apr. 2019 - 31 Mar. 2022 - Analysis of the regulation of TORC2 signaling by phosphatidylserine
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B)
Kyoto University
01 Apr. 2017 - 31 Mar. 2019 - Involvement of glycolytic metabolite in pathogenic mechanism of diabetes: verification of new model of insulin-resistance development
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research
Kyoto University
01 Apr. 2014 - 31 Mar. 2016 - メタボリックシグナリング:解糖系代謝物によるTORC2の新規活性化機構の解明
科学研究費助成事業, 日本学術振興会, 特別研究員奨励費
京都大学
01 Apr. 2012 - 31 Mar. 2015