Ph.D., Tohoku University

Animal Physiology

1999, Tohoku University, Graduate School of Agricultural Science

2002, Tohoku University, Graduate School of Agricultural Science

1997, Tohoku University, Faculty of Agriculture

評議員, 北信越畜産学会

2023
日本畜産学会賞

2023
Animal Science Journal Reviewers Award

2006
Fellows Award for Research Excellence in NIH

2004
Award for Young Scientist from Japanese Society of Animal Science

The role of endoplasmic reticulum stress in metabolic diseases and mammary epithelial cell homeostasis in dairy cows
Yonekura, Shinichi*
Animal Science Journal, 95(1), e13935, Jan. 2024

Palmitic acid-induced cell death: impact of endoplasmic reticulum and oxidative stress, mitigated by L-citrulline
Md Rezwanul, Habib; Tokutake, Yukako; Yonekura, Shinichi*
Animal Bioscience, in press, 2024

Effects of starvation-induced negative energy balance on endoplasmic reticulum stress in the liver of cows
Islam, Md Aminul; Adachi, Shuya; Shiiba, Yuichiroh; Takeda, Ken-ichi; Haga, Satoshi; Yonekura, Shinichi*;
ANIMAL BIOSCIENCE, 35(1), 22-28, Jan. 2022

XBP1u Is Involved in C2C12 Myoblast Differentiation via Accelerated Proteasomal Degradation of Id3
Hayashi, Satoko; Sakata, Shotaro; Kawamura, Shotaro; Tokutake, Yukako; Yonekura, Shinichi*;
Frontiers in Physiology, 13, 796190, 2022

Mild heat stimulation facilitates muscle hypertrophy in C2C12 and mouse satellite cells through myokine release to the culture medium
Hayashi, Satoko; Yonekura, Shinichi*;
Biochemical and biophysical research communications, 635, 161-168, 2022

Insulin-like growth factor-1 induces IRE1-XBP1-dependent endoplasmic reticulum biogenesis in bovine mammary epithelial cells
Sharmin, Mst Mamuna; Hayashi, Satoko; Miyaji, Makoto; Ishizaki, Hiroshi; Matsuyama, Hiroki; Haga, Satoshi; Yonekura, Shinichi*;
JOURNAL OF DAIRY SCIENCE, 104(11), 12094-12104, Nov. 2021

Protective effects of 5-aminolevulinic acid on heat stress in bovine mammary epithelial cells
Islam, Md Aminul; Noguchi, Yoko; Taniguchi, Shin; Yonekura, Shinichi*;
ANIMAL BIOSCIENCE, 34(6), 1006-1013, Jun. 2021

Myogenetic oligodeoxynucleotide (myoDN) recovers the differentiation of skeletal muscle myoblasts deteriorated by diabetes mellitus.
Nakamura, Shunichi; Yonekura, Shinichi; Shimosato, Takeshi; Takaya, Tomohide
Frontiers in Physiology, 12, 679152, 24 May 2021

5-ALA Attenuates the Palmitic Acid-Induced ER Stress and Apoptosis in Bovine Mammary Epithelial Cells
Sharmin, Mst Mamuna; Islam, Md Aminul; Yamamoto, Itsuki; Taniguchi, Shin; Yonekura, Shinichi*;
MOLECULES, 26(4), Feb. 2021

Effects of fatty acids on inducing endoplasmic reticulum stress in bovine mammary epithelial cells
Sharmin, Mst Mamuna; Mizusawa, Moeko; Hayashi, Satoko; Arai, Wataru; Sakata, Shotaro; Yonekura, Shinichi*;
JOURNAL OF DAIRY SCIENCE, 103(9), 8643-8654, Sep. 2020

TRPV4 Increases the Expression of Tight Junction Protein-Encoding Genes via XBP1 in Mammary Epithelial Cells
Islam, Md Aminul; Mizusawa, Moeko; Sharmin, Mst Mamuna; Hayashi, Satoko; Yonekura, Shinichi*;
ANIMALS, 10(7), Jul. 2020

IRE1-XBP1 Pathway of the Unfolded Protein Response Is Required during Early Differentiation of C2C12 Myoblasts
Tokutake, Yukako; Yamada, Keita; Hayashi, Satoko; Arai, Wataru; Watanabe, Takafumi; Yonekura, Shinichi*;
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(1), 2020

Mild heat stress induces transcription of the beta-casein gene via unfolded protein response-activated XBP1 signaling in undifferentiated mammary epithelial cells
Mizusawa, Moeko; Sharmin, Mamuna; Yonekura, Shinichi*;
ANIMAL SCIENCE JOURNAL, 90(8), 1026-1032, Aug. 2019

Thermal stimulation at 39 degrees C facilitates the fusion and elongation of C2C12 myoblasts
Hayashi, Satoko; Yonekura, Shinichi*;
ANIMAL SCIENCE JOURNAL, 90(8), 1008-1017, Aug. 2019

Peg1/Mest, an imprinted gene, is involved in mammary gland maturation
Yonekura, Shinichi*; Ohata, Masaki; Tsuchiya, Megumi; Tokita, Hitomi; Mizusawa, Moeko; Tokutake, Yukako;
JOURNAL OF CELLULAR PHYSIOLOGY, 234(2), 1080-1087, Feb. 2019

Adzuki bean (Vigna angularis) extract reduces amyloid- beta aggregation and delays cognitive impairment in Drosophila models of Alzheimer's disease
Miyazaki, Honami; Okamoto, Yoko; Motoi, Aya; Watanabe, Takafumi; Katayama, Shigeru; Kawahara, Sei-ichi; Makabe, Hidefumi; Fujii, Hiroshi; Yonekura, Shinichi*;
NUTRITION RESEARCH AND PRACTICE, 13(1), 64-69, Feb. 2019

骨格筋分化の制御に寄与するIRE1-XBP1の機能解明
徳武 優佳子;山田 啓太;林 聡子;坂田 章太郎;米倉 真一
栄養生理研究会報 = Reviews on Animal Nutrition and Metabolism, 63(1), 15-22, 2019

The unfolded protein response is involved in both differentiation and apoptosis of bovine mammary epithelial cells
Yonekura, Shinichi*; Tsuchiya, Megumi; Tokutake, Yukako; Mizusawa, Moeko; Nakano, Miwa; Miyaji, Makoto; Ishizaki, Hiroshi; Haga, Satoshi;
JOURNAL OF DAIRY SCIENCE, 101(4), 3568-3578, Apr. 2018

The role of unfolded protein response in differentiation of mammary epithelial cells
Tsuchiya, Megumi; Koizumi, Yumiko; Hayashi, Satoko; Hanaoka, Miyuki; Tokutake, Yukako; Yonekura, Shinichi*
Biochemical and biophysical research communications, 484(4), 903-908, 2017

Subcellular Localization and Polymorphism of Bovine FABP4 in Bovine Intramuscular Adipocytes
Yonekura, Shinichi*; Hirota, Shohei; Miyazaki, Honami; Tokutake, Yukako;
ANIMAL BIOTECHNOLOGY, 27(2), 96-103, 2016

Soluble extract of soybean fermented with Aspergillus oryzae GB 107 inhibits fat accumulation in cultured 3T3-L1 adipocytes
So, Kyoung-Ha; Suzuki, Yasuki; Yonekura, Shinichi; Suzuki, Yutaka; Lee, Chan Ho; Kim, Sung Woo; Katoh, Kazuo; Roh, Sang-Gun;
NUTRITION RESEARCH AND PRACTICE, 9(4), 439-444, Aug. 2015

ALS-Linked P56S-VAPB Mutation Impairs the Formation of Multinuclear Myotube in C2C12 Cells
Tokutake, Yukako; Yamada, Keita; Ohata, Masaki; Obayashi, Yoshihito; Tsuchiya, Megumi; Yonekura, Shinichi*
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 16(8), 18628-18641, Aug. 2015

Inhibitory/Suppressive Oligodeoxynucleotide Nanocapsules as Simple Oral Delivery Devices for Preventing Atopic Dermatitis in Mice
Wang, Yeqin; Yamamoto, Yoshinari; Shigemori, Suguru; Watanabe, Takafumi; Oshiro, Kazushi; Wang, Xinyu; Wang, Pengfei; Sato, Takashi; Yonekura, Shinichi; Tanaka, Sachi; Kitazawa, Haruki; Shimosato, Takeshi;
MOLECULAR THERAPY, 23(2), 297-309, Feb. 2015

ALS-associated P56S-VAPB mutation restrains 3T3-L1 preadipocyte differentiation
Tokutake, Yukako; Gushima, Kazunari; Miyazaki, Honami; Shimosato, Takeshi; Yonekura, Shinichi*
Biochemical and biophysical research communications, 460(3), 831-837, 2015

Effect of single nucleotide polymorphisms in GH gene promoter region on carcass traits and intramuscular fatty acid compositions in Japanese Black cattle
Sugita, Haruna; Ardiyanti, Astrid; Yokota, Shoko; Yonekura, Shinichi; Hirayama, Takuji; Shoji, Noriaki; Yamauchi, Eri; Suzuki, Keiichi; Katoh, Kazuo; Roh, Sang-Gun;
LIVESTOCK SCIENCE, 165, 15-21, Jul. 2014

Histological analysis of glucagon-like peptide-1 receptor expression in chicken pancreas
Watanabe, Takafumi; Nishimura, Kei; Hosaka, Yoshinao Z.; Shimosato, Takeshi; Yonekura, Shinichi; Suzuki, Daisuke; Takemoto, Chihiro; Monir, Mohammad Moniruzzaman; Hiramatsu, Kohzy;
CELL AND TISSUE RESEARCH, 357(1), 55-61, Jul. 2014

Influences of protein ingestion on glucagon-like peptide (GLP)-1-immunoreactive endocrine cells in the chicken ileum
Monir, Mohammad M.; Hiramatsu, Kohzy; Matsumoto, Sachiko; Nishimura, Kei; Takemoto, Chihiro; Shioji, Tomomi; Watanabe, Takafumi; Kita, Kazumi; Yonekura, Shinichi; Roh, Sang Gun
ANIMAL SCIENCE JOURNAL, 85(5), 581-587, May 2014

Dexamethasone and Acetate Modulate Cytoplasmic Leptin in Bovine Preadipocytes
Yonekura, Shinichi*; Hirota, Shohei; Tokutake, Yukako; Rose, Michael T.; Katoh, Kazuo; Aso, Hisashi
ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, 27(4), 567-573, Apr. 2014

Proliferating bovine intramuscular preadipocyte cells synthesize leptin
Yonekura, S*.; Tokutake, Y.; Hirota, S.; Rose, M. T.; Katoh, K.; Aso, H.
DOMESTIC ANIMAL ENDOCRINOLOGY, 45(1), 33-37, Jul. 2013

Expression of the immunoreactive buckwheat major allergenic storage protein in Lactococcus lactis
Shigemori, Suguru; Yonekura, Shinichi; Sato, Takashi; Otani, Hajime; Shimosato, Takeshi
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 97(8), 3603-3611, Apr. 2013

Expression of a Biologically Active GFP-alpha(S1)-Casein Fusion Protein in Lactococcus lactis
Shigemori, Suguru; Yonekura, Shinichi; Sato, Takashi; Nakanishi, Maya; Otani, Hajime; Shimosato, Takeshi
CURRENT MICROBIOLOGY, 64(6), 569-575, Jun. 2012

AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster
Kametaka, Satoshi; Kametaka, Ai; Yonekura, Shinichi; Haruta, Mineyuki; Takenoshita, Seiichi; Goto, Satoshi; Waguri, Satoshi
JOURNAL OF CELL SCIENCE, 125(3), 634-648, 01 Feb. 2012

Conserved Alternative Splicing and Expression Patterns of Arthropod N-Cadherin
Hsu, Shu-Ning; Yonekura, Shinichi; Ting, Chun-Yuan; Robertson, Hugh M.; Iwai, Youichi; Uemura, Tadashi; Lee, Chi-Hon; Chiba, Akira
PLOS GENETICS, 5(4), Apr. 2009

Tiling of R7 axons in the Drosophila visual system is mediated both by transduction of an activin signal to the nucleus and by mutual repulsion
Ting, Chun-Yuan; Herman, Tory; Yonekura, Shinichi; Gao, Shuying; Wang, Jian; Serpe, Mihaela; O'Connor, Michael B.; Zipursky, S. Lawrence; Lee, Chi-Hon
NEURON, 56(5), 793-806, 06 Dec. 2007

Alternative splicing expands spatiotemporal expression complexity of arthropod N-Cadherin
Hsu, Shu-Ning; Yonekura, Shinichi; Ting, Chun-Yuan; Robertson, Hugh M.; Lee, Chi-Hon; Chiba, Akira
DEVELOPMENTAL BIOLOGY, 306(1), 376-376, 01 Jun. 2007

Adhesive but not signaling activity of Drosophila N-cadherin is essential for target selection of photoreceptor afferents
Yonekura, Shinichi; Xu, Lei; Ting, Chun-Yuan; Lee, Chi-Hon
DEVELOPMENTAL BIOLOGY, 304(2), 759-770, 15 Apr. 2007

The variable transmembrane domain of Drosophila N-cadherin regulates adhesive activity
Yonekura, Shinichi; Ting, Chun-Yuan; Neves, Guilherme; Hung, Kimberly; Hsu, Shu-ning; Chiba, Akira; Chess, Andrew; Lee, Chi-Hon
MOLECULAR AND CELLULAR BIOLOGY, 26(17), 6598-6608, Sep. 2006

Growth hormone and lactogenic hormones can reduce the leptin mRNA expression in bovine mammary epithelial cells
Yonekura, S; Sakamoto, K; Komatsu, T; Hagino, A; Katoh, K; Obara, Y
DOMESTIC ANIMAL ENDOCRINOLOGY, 31(1), 88-96, Jul. 2006

Drosophila N-cadherin functions in the first stage of the two-stage layer-selection process of R7 photoreceptor afferents
Ting, CY*; Yonekura, S*; Chung, P; Hsu, SN; Robertson, HM; Chiba, A; Lee, CH. *contributed equally to this work.
DEVELOPMENT, 132(5), 953-963, Mar. 2005

Octanoate stimulates cytosolic triacylglycerol accumulation and CD36 mRNA expression but inhibits Acetyl coenzyme A carboxylase activity in primary cultured bovine mammary epithelial cells
Yonezawa, T; Yonekura, S; Sanosaka, M; Hagino, A; Katoh, K; Obara, Y
JOURNAL OF DAIRY RESEARCH, 71(4), 398-404, Nov. 2004

Effects of long-chain fatty acids on cytosolic triacylglycerol accumulation and lipid droplet formation in primary cultured bovine mammary epithelial cells
Yonezawa, T; Yonekura, S; Kobayashi, Y; Hagino, A; Katoh, K; Obara, Y
JOURNAL OF DAIRY SCIENCE, 87(8), 2527-2534, Aug. 2004

Suppressing effects of bisphenol A on the secretory function of ovine anterior pituitary cells
Katoh, K; Matsuda, A; Ishigami, A; Yonekura, S; Ishiwata, H; Chen, C; Obara, Y
CELL BIOLOGY INTERNATIONAL, 28(6), 463-469, 2004

Effects of acetate and butyrate on the expression of leptin and short-form leptin receptor in bovine and rat anterior pituitary cells
Yonekura, S; Senoo, T; Kobayashi, Y; Yonezawa, T; Katoh, K; Obara, Y
GENERAL AND COMPARATIVE ENDOCRINOLOGY, 133(2), 165-172, Sep. 2003

In vitro differentiation of a cloned bovine mammary epithelial cell
Rose, MT; Aso, H; Yonekura, S; Komatsu, T; Hagino, A; Ozutsumi, K; Obara, Y
JOURNAL OF DAIRY RESEARCH, 69(3), 345-355, Aug. 2002

Effects of nutritional conditions around weaning on carbonic anhydrase activity in the parotid gland and ruminal and abomasal epithelia of Holstein calves
Kitade, K; Takahashi, K; Yonekura, S; Katsumata, N; Furukawa, G; Ohsuga, S; Nishita, T; Katoh, K; Obara, Y
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY, 172(5), 379-385, Jul. 2002

Effects of aging and weaning on mRNA expression of leptinand CCK receptors in the calf rumen and abomasum
Yonekura, S; Kitade, K; Furukawa, G; Takahashi, K; Katsumata, N; Katoh, K; Obara, Y
DOMESTIC ANIMAL ENDOCRINOLOGY, 22(1), 25-35, Mar. 2002

Relationship between serum leptin concentrations and the marbling scores in Japanese Black Cattle.
Yonekura S, Kitade K, Furukawa G, Takahashi K, Katsumata N, Katoh K, Obara Y.
Anim Sci J, 22, 25-35, 2002

Effects of adenosine 5'-triphosphate and growth hormone on cellular H+ transport and calcium ion concentrations in cloned bovine mammary epithelial cells
Katoh, K; Komatsu, T; Yonekura, S; Ishiwata, H; Hagino, A; Obara, Y
JOURNAL OF ENDOCRINOLOGY, 169(2), 381-388, May 2001

新編　家畜生理学
加藤和雄・古瀬充宏・盧尚建・山崎淳・佐野宏明・麻生久・野地智法・米倉真一・萩野顕彦・林英明
養賢堂, 2015

北信越畜産学会

The Molecular Biology Society of Japan

Japanese Society of Animal Science

American Dairy Science Association

乳腺の小胞体ストレス応答機構に着眼した泌乳制御機序解明と泌乳平準化研究への新展開
科学研究費補助金, 基盤研究（B)
2020 - 2022

小胞体ストレス応答機構に着目した筋肥大化メカニズムの解明
科学研究費補助金, 基盤研究（C)
2017 - 2019

Elucidation of the intracellular mechanism related to milk yield of mammary epithelial cells

Elucidation of in vivo mechanisms associated with perinatal diseases in dairy cows

Molecular mechanisms regulating myogenic determination and differentiation.