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HIGUCHI KEIICHI｜Shinshu University Researcher List

HIGUCHI KEIICHI

School of Medicine　Department of Sports Medical Sciences　

Professor　

Researcher Information

Degree

  • Ph.D., Kyoto University

Research Keyword

    Sports Medical Science, Aging, Model mice, Amyloidosis

Field Of Study

  • Pathological biochemistry
  • Sports sciences
  • Experimental pathology
  • Aging Biology
  • Amyloidosis

TEL

    81-263-37-2691

Career

  • 2024 - Present
    Meio University, スポーツ健康科学研究科, 教授
  • 2023 - 2024
    Meio University, Faculty of Human Health Sciences, Professor, Ph.D.
  • 2021 - Present
    Shinshu University, 名誉教授
  • 2021 - Present
    Shinshu University, バイオメディカル研究所, 特任教授
  • 2021 - 2023
    Nagano University of Health and Medicine, Community Health Care Research Center, Professor
  • 2019 - 2021
    信州大学バイオメディカル 研究所, ニューロヘルスイノベーション部門, 教授
  • 2018
    信州大学先鋭領域融合研究群バイオメディカル研究所神経難病学部門
  • 1998 - 2019
    Shinshu University, Graduate School of Medicine Medical Sciences, Professor
  • 1988 - 1998
    Kyoto University, 胸部疾患研究所 老化生物学部門, 講師
  • 1986 - 1988
    National Institute of Health （U.S.), National Institute on Heart, Lung and Blood Institute, Visiting Fellow
  • 1984 - 1986
    Chest Disease Research Institute, Department of Experimental Pathology, Instructor

Educational Background

  • 1980 - 1984, Kyoto University, Graduate School of Medicine, 病理学
  • 1978 - 1980, Kyoto University, Graduate School of Agriculture, 畜産学
Research activity information

Paper

  • Classification of amyloidosis and protein misfolding disorders in animals 2024: A review on pathology and diagnosis.
    Susumu Iwaide; Tomoaki Murakami; Niki Sedghi Masoud; Natsumi Kobayashi; Jessica S Fortin; Hiroki Miyahara; Keiichi Higuchi; James K Chambers
    Veterinary pathology, 3009858241283750-3009858241283750, Oct. 2024リポジトリ電子ジャーナル
  • Insights into the structural basis of amyloid resistance provided by cryo-EM structures of AApoAII amyloid fibrils.
    Giada Andreotti; Julian Baur; Marijana Ugrina; Peter Benedikt Pfeiffer; Max Hartmann; Sebastian Wiese; Hiroki Miyahara; Keiichi Higuchi; Nadine Schwierz; Matthias Schmidt; Marcus Fändrich
    Journal of molecular biology, 168441-168441, Jan. 2024リポジトリ電子ジャーナル
  • BALB.NCT-Cpox nct is a unique mouse model of hereditary coproporphyria.
    Xiaojing Kang; Shin Shimada; Hiroki Miyahara; Keiichi Higuchi; Masayuki Mori
    Molecular genetics and metabolism reports, 35, 100964-100964, Jun. 2023リポジトリ電子ジャーナル
  • Macrophages in the reticuloendothelial system inhibit early induction stages of mouse apolipoprotein A-II amyloidosis.
    Hiroki Miyahara; Jian Dai; Ying Li; Xiaoran Cui; Hibiki Takeuchi; Naomi Hachiya; Fuyuki Kametani; Masahide Yazaki; Masayuki Mori; Keiichi Higuchi
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 30(2), 225-238, Jun. 2023リポジトリ電子ジャーナル
  • Renal Function in Aged C57BL/6J Mice Is Impaired by Deposition of Age-Related Apolipoprotein A-II Amyloid Independent of Kidney Aging.
    Ying Li; Jian Dai; Fuyuki Kametani; Masahide Yazaki; Akihito Ishigami; Masayuki Mori; Hiroki Miyahara; Keiichi Higuchi
    The American journal of pathology, 193(6), 725-739, Jun. 2023リポジトリ電子ジャーナル
  • Cyba and Nox2 mutant rats show different incidences of eosinophilia in the genetic background- and sex-dependent manner.
    Masayuki Mori; Jian Dai; Hiroki Miyahara; Ying Li; Xiaojing Kang; Kazuto Yoshimi; Tomoji Mashimo; Keiichi Higuchi; Kiyoshi Matsumoto
    Experimental animals, 72(2), 233-241, May 2023リポジトリ電子ジャーナル
  • Polygenic control of the wavy coat of the NCT mouse: involvement of an intracisternal A particle insertional mutation of the protease, serine 53 (Prss53) gene, and a modifier gene.
    Masayuki Mori; Chang Liu; Takahiro Yoshizawa; Hiroki Miyahara; Jian Dai; Yuichi Igarashi; Xiaoran Cui; Ying Li; Xiaojing Kang; Keiichi Higuchi
    Mammalian genome : official journal of the International Mammalian Genome Society, 33(3), 451-464, Sep. 2022リポジトリ電子ジャーナル
  • Exercise suppresses mouse systemic AApoAII amyloidosis through enhancement of the p38 MAPK signaling pathway.
    Xiaoran Cui; Jinko Sawashita; Jian Dai; Chang Liu; Yuichi Igarashi; Masayuki Mori; Hiroki Miyahara; Keiichi Higuchi
    Disease models & mechanisms, 15(3), Mar. 2022リポジトリ電子ジャーナル
  • Involvement of increased endoplasmic reticulum stress in the development of cataracts in BALB.NCT-Cpoxnct mice.
    Chang Liu; Hiroki Miyahara; Jian Dai; Xiaoran Cui; Ying Li; Xiaojing Kang; Keiichi Higuchi; Masayuki Mori
    Experimental eye research, 215, 108905-108905, Feb. 2022リポジトリ電子ジャーナル
  • Glavonoid-rich oil supplementation reduces stearoyl-coenzyme A desaturase 1 expression and improves systemic metabolism in diabetic, obese KK-Ay mice.
    Yuichi Igarashi; Shiho Iida; Jian Dai; Jia Huo; Xiaoran Cui; Jinko Sawashita; Masayuki Mori; Hiroki Miyahara; Keiichi Higuchi
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 140, 111714-111714, Aug. 2021リポジトリ電子ジャーナル
  • Development of diagnostic antibodies against immunoglobulin heavy chain variable region for heavy chain amyloidosis (AH amyloidosis).
    Mayuko Nakagawa; Masahide Yazaki; Fuyuki Kametani; Nagaaki Katoh; Tsuneaki Yoshinaga; Keiichi Higuchi; Yoshiki Sekijima
    Pathology international, 71(4), 245-254, Apr. 2021リポジトリ電子ジャーナル
  • Dialysis-related amyloidosis associated with a novel β2-microglobulin variant.
    Hiroki Mizuno; Junichi Hoshino; Masatomo So; Yuta Kogure; Takeshi Fujii; Yoshifumi Ubara; Kenmei Takaichi; Tetsuko Nakaniwa; Hideaki Tanaka; Genji Kurisu; Fuyuki Kametani; Mayuko Nakagawa; Tsuneaki Yoshinaga; Yoshiki Sekijima; Keiichi Higuchi; Yuji Goto; Masahide Yazaki
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 28(1), 42-49, Mar. 2021リポジトリ電子ジャーナル
  • Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARα signaling pathway.
    Jian Dai; Ying Li; Fuyuki Kametani; Xiaoran Cui; Yuichi Igarashi; Jia Huo; Hiroki Miyahara; Masayuki Mori; Keiichi Higuchi
    eLife, 10, Jan. 2021リポジトリ電子ジャーナル
  • [The senescence-accelerated mouse as a model for geriatrics and aging biology].
    Masayuki Mori; Keiichi Higuchi
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 153(4), 179-185, 2019リポジトリ電子ジャーナル
  • Suppression of Mouse AApoAII Amyloidosis Progression by Daily Supplementation with Oxidative Stress Inhibitors.
    Jian Dai; Xin Ding; Hiroki Miyahara; Zhe Xu; Xiaoran Cui; Yuichi Igarashi; Jinko Sawashita; Masayuki Mori; Keiichi Higuchi
    Oxidative medicine and cellular longevity, 2019, 1263274-1263274, 2019リポジトリ電子ジャーナル
  • Amyloidosis-inducing activity of blood cells in mouse AApoAII amyloidosis.
    Xin Ding; Yingye Liu; Mu Yang; Lin Li; Hiroki Miyahara; Jian Dai; Zhe Xu; Kiyoshi Matsumoto; Masayuki Mori; Keiichi Higuchi; Jinko Sawashita
    Experimental animals, 67(2), 105-115, May 2018リポジトリ電子ジャーナル
  • Apolipoprotein A-II induces acute-phase response associated AA amyloidosis in mice through conformational changes of plasma lipoprotein structure.
    Mu Yang; Yingye Liu; Jian Dai; Lin Li; Xin Ding; Zhe Xu; Masayuki Mori; Hiroki Miyahara; Jinko Sawashita; Keiichi Higuchi
    Scientific reports, 8(1), 5620-5620, Apr. 2018リポジトリ電子ジャーナル
  • Comprehensive proteomic profiles of mouse AApoAII amyloid fibrils provide insights into the involvement of lipoproteins in the pathology of amyloidosis.
    Hiroki Miyahara; Jinko Sawashita; Eri Ishikawa; Mu Yang; Xin Ding; Yingye Liu; Naomi Hachiya; Fuyuki Kametani; Masahide Yazaki; Masayuki Mori; Keiichi Higuchi
    Journal of proteomics, 172, 111-121, Feb. 2018リポジトリ電子ジャーナル
  • Coenzyme Q10 Prevents Senescence and Dysfunction Caused by Oxidative Stress in Vascular Endothelial Cells.
    Jia Huo; Zhe Xu; Kazunori Hosoe; Hiroshi Kubo; Hiroki Miyahara; Jian Dai; Masayuki Mori; Jinko Sawashita; Keiichi Higuchi
    Oxidative medicine and cellular longevity, 2018, 3181759-3181759, 2018リポジトリ電子ジャーナル
  • Coenzyme Q10 Improves Lipid Metabolism and Ameliorates Obesity by Regulating CaMKII-Mediated PDE4 Inhibition.
    Zhe Xu; Jia Huo; Xin Ding; Mu Yang; Lin Li; Jian Dai; Kazunori Hosoe; Hiroshi Kubo; Masayuki Mori; Keiichi Higuchi; Jinko Sawashita
    Scientific reports, 7(1), 8253-8253, Aug. 2017リポジトリ電子ジャーナル
  • SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions.
    Ichiro Akiguchi; Mercè Pallàs; Herbert Budka; Haruhiko Akiyama; Masaki Ueno; Jingxian Han; Hideo Yagi; Tomohumi Nishikawa; Yoichi Chiba; Hiroshi Sugiyama; Ryoya Takahashi; Keiko Unno; Keiichi Higuchi; Masanori Hosokawa
    Neuropathology : official journal of the Japanese Society of Neuropathology, 37(4), 293-305, Aug. 2017リポジトリ電子ジャーナル
  • Marked biochemical difference in amyloid proportion between intra- and extraocular tissues in a liver-transplanted patient with hereditary ATTR amyloidosis.
    Tsuneaki Yoshinaga; Masahide Yazaki; Fuyuki Kametani; Yoshiki Sekijima; Yasuhiro Iesato; Teruyoshi Miyahara; Ayako Tsuchiya-Suzuki; Kenji Sano; Keiichi Higuchi; Shu-Ichi Ikeda
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 24(1), 17-23, Mar. 2017リポジトリ電子ジャーナル
  • Apolipoprotein A-II accelerates reactive AA amyloidosis.
    Mu Yang; Yingye Liu; Lin Li; Hiroki Miyahara; Xin Ding; Jian Dai; Jinko Sawashita; Masayuki Mori; Keiichi Higuchi
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 24(sup1), 147-148, Mar. 2017リポジトリ電子ジャーナル
  • Caloric restriction prevents the progression of murine AApoAII amyloidosis.
    Jinko Sawashita; Lin Li; Yingye Liu; Xin Ding; Mu Yang; Zhe Xu; Keiichi Higuchi
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 24(sup1), 171-172, Mar. 2017リポジトリ電子ジャーナル
  • Caloric restriction reduces the systemic progression of mouse AApoAII amyloidosis.
    Lin Li; Jinko Sawashita; Xin Ding; Mu Yang; Zhe Xu; Hiroki Miyahara; Masayuki Mori; Keiichi Higuchi
    PloS one, 12(2), e0172402, 2017リポジトリ電子ジャーナル
  • Serum amyloid A expression in the breast cancer tissue is associated with poor prognosis.
    Mu Yang; Fangfang Liu; Kayoko Higuchi; Jinko Sawashita; Xiaoying Fu; Li Zhang; Lanjing Zhang; Li Fu; Zhongsheng Tong; Keiichi Higuchi
    Oncotarget, 7(24), 35843-35852, Jun. 2016リポジトリ電子ジャーナル
  • The pathological and biochemical identification of possible seed-lesions of transmitted transthyretin amyloidosis after domino liver transplantation.
    Tsuneaki Yoshinaga; Masahide Yazaki; Yoshiki Sekijima; Fuyuki Kametani; Kana Miyashita; Naomi Hachiya; Tomohiro Tanaka; Norihiro Kokudo; Keiichi Higuchi; Shu-Ichi Ikeda
    The journal of pathology. Clinical research, 2(2), 72-9, Apr. 2016リポジトリ電子ジャーナル
  • The factors affecting adherence to a long-term interval walking training program in middle-aged and older people.
    Shizue Masuki; Masayuki Mori; Yasuharu Tabara; Akihiro Sakurai; Shigenari Hashimoto; Mayuko Morikawa; Ken Miyagawa; Eri Sumiyoshi; Tetsuro Miki; Keiichi Higuchi; Hiroshi Nose
    Journal of applied physiology (Bethesda, Md. : 1985), 118(5), 595-603, Mar. 2015リポジトリ電子ジャーナル
  • Extracellular deposition of mouse senile AApoAII amyloid fibrils induced different unfolded protein responses in the liver, kidney, and heart.
    Hongmin Luo; Jinko Sawashita; Geng Tian; Yingye Liu; Lin Li; Xin Ding; Zhe Xu; Mu Yang; Hiroki Miyahara; Masayuki Mori; Jinze Qian; Yaoyong Wang; Keiichi Higuchi
    Laboratory investigation; a journal of technical methods and pathology, 95(3), 320-33, Mar. 2015リポジトリ電子ジャーナル
  • C-terminal sequence of amyloid-resistant type F apolipoprotein A-II inhibits amyloid fibril formation of apolipoprotein A-II in mice.
    Jinko Sawashita; Beiru Zhang; Kazuhiro Hasegawa; Masayuki Mori; Hironobu Naiki; Fuyuki Kametani; Keiichi Higuchi
    Proceedings of the National Academy of Sciences of the United States of America, 112(8), E836-45, Feb. 2015リポジトリ電子ジャーナル
  • A nonsense nucleotide substitution in the oculocutaneous albinism II gene underlies the original pink-eyed dilution allele (Oca2(p)) in mice.
    Haruka Shoji; Yukiko Kiniwa; Ryuhei Okuyama; Mu Yang; Keiichi Higuchi; Masayuki Mori
    Experimental animals, 64(2), 171-9, 2015リポジトリ電子ジャーナル
  • The first pure form of Ostertag-type amyloidosis in Japan: a sporadic case of hereditary fibrinogen Aα-chain amyloidosis associated with a novel frameshift variant.
    Masahide Yazaki; Tsuneaki Yoshinaga; Yoshiki Sekijima; Saori Nishio; Yuji Kanizawa; Fuyuki Kametani; Kana Miyashita; Naomi Hachiya; Keiichi Higuchi; Shu-ichi Ikeda
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 22(2), 142-4, 2015リポジトリ電子ジャーナル
  • NFκB2 Gene as a Novel Candidate that Epigenetically Responds to Interval Walking Training
    Zhang Y, Hashimoto S, Fujii C, Hida S, Ito K, Matsumura T, Sakaizawa T, Morikawa M, Masuki S, Nose H, Higuchi K, Nakajima K, Taniguchi S
    Int J Sports Med, 36(9), 769-775, 2015
  • Novel frame-shift mutation in Slc5a2 encoding SGLT2 in a strain of senescence-accelerated mouse SAMP10.
    Keiko Unno; Hiroyuki Yamamoto; Masateru Toda; Shiori Hagiwara; Kazuaki Iguchi; Minoru Hoshino; Fumiyo Takabayashi; Sanae Hasegawa-Ishii; Atsuyoshi Shimada; Masanori Hosokawa; Keiichi Higuchi; Masayuki Mori
    Biochemical and biophysical research communications, 454(1), 89-94, Nov. 2014リポジトリ電子ジャーナル
  • The toxicity mechanisms of action of Aβ25-35 in isolated rat cardiac myocytes.
    Beiru Zhang; Xiaohui Bian; Ping He; Xiaoying Fu; Keiichi Higuchi; Xu Yang; Detian Li
    Molecules (Basel, Switzerland), 19(8), 12242-57, Aug. 2014リポジトリ電子ジャーナル
  • [Senile systemic amyloidosis].
    Masahide Yazaki; Keiichi Higuchi
    Brain and nerve = Shinkei kenkyu no shinpo, 66(7), 817-26, Jul. 2014リポジトリ
  • Ubiquinol-10 supplementation activates mitochondria functions to decelerate senescence in senescence-accelerated mice.
    Geng Tian; Jinko Sawashita; Hiroshi Kubo; Shin-ya Nishio; Shigenari Hashimoto; Nobuyoshi Suzuki; Hidekane Yoshimura; Mineko Tsuruoka; Yaoyong Wang; Yingye Liu; Hongming Luo; Zhe Xu; Masayuki Mori; Mitsuaki Kitano; Kazunori Hosoe; Toshio Takeda; Shin-ichi Usami; Keiichi Higuchi
    Antioxidants & redox signaling, 20(16), 2606-20, Jun. 2014リポジトリ電子ジャーナル
  • AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform.
    Masayuki Mori; Geng Tiang; Keiichi Higuchi
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 21(1), 1-8, Mar. 2014リポジトリ電子ジャーナル
  • Transmission of Systemic AA Amyloidosis in Animals
    Murakami, T; Ishiguro, N; Higuchi, K
    VETERINARY PATHOLOGY, 51(2), 363-371, Mar. 2014WebofScienceリポジトリ電子ジャーナル
  • Diversity and complexity of the mouse Saa1 and Saa2 genes.
    Masayuki Mori; Geng Tian; Akira Ishikawa; Keiichi Higuchi
    Experimental animals, 63(1), 99-106, 2014リポジトリ
  • Voluntary locomotion linked with cerebral activation is mediated by vasopressin V1a receptors in free-moving mice
    Shizue Masuki; Eri Sumiyoshi; Taka-aki Koshimizu; Jinze Qian; Keiichi Higuchi; Gozoh Tsujimoto; Hiroshi Nose
    JOURNAL OF PHYSIOLOGY-LONDON, 591(14), 3651-3665, Jul. 2013, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Hereditary cataract of the Nakano mouse: Involvement of a hypomorphic mutation in the coproporphyrinogen oxidase gene.
    Masayuki Mori; Saki Gotoh; Shigeru Taketani; Hiroshi Hiai; Keiichi Higuchi
    Experimental eye research, 112, 45-50, Jul. 2013リポジトリ電子ジャーナル
  • Transmission of AA amyloidosis may cause outbreaks of amyloid A amyloidosis in chickens.
    Keiichi Higuchi
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 20(2), 59-60, Jun. 2013リポジトリ電子ジャーナル
  • Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes.
    Kumpei Tanisawa; Eri Mikami; Noriyuki Fuku; Yoko Honda; Shuji Honda; Ikuro Ohsawa; Masafumi Ito; Shogo Endo; Kunio Ihara; Kinji Ohno; Yuki Kishimoto; Akihito Ishigami; Naoki Maruyama; Motoji Sawabe; Hiroyoshi Iseki; Yasushi Okazaki; Sanae Hasegawa-Ishii; Shiro Takei; Atsuyoshi Shimada; Masanori Hosokawa; Masayuki Mori; Keiichi Higuchi; Toshio Takeda; Mitsuru Higuchi; Masashi Tanaka
    BMC genomics, 14, 248-248, Apr. 2013リポジトリ電子ジャーナル
  • An interleukin-33 gene polymorphism is a modifier for eosinophilia in rats
    Luo, H; Higuchi, K; Matsumoto, K; Mori, M
    GENES AND IMMUNITY, 14(3), 192-197, 2013WebofScienceリポジトリ電子ジャーナル
  • [Can prion-like propagation occur in neurodegenerative diseases?: in view of transmissible systemic amyloidosis].
    Kunihiro Yoshida; Keiichi Higuchi; Shu-ichi Ikeda
    Brain and nerve = Shinkei kenkyu no shinpo, 64(6), 665-74, Jun. 2012リポジトリ
  • Cheetahs have 4 serum amyloid a genes evolved through repeated duplication events.
    Lei Chen; Yumi Une; Keiichi Higuchi; Masayuki Mori
    The Journal of heredity, 103(1), 115-29, 2012リポジトリ電子ジャーナル
  • In vivo molecular imaging of peripheral amyloidosis using heparin-binding peptides.
    Jonathan S Wall; Tina Richey; Alan Stuckey; Robert Donnell; Sallie Macy; Emily B Martin; Angela Williams; Keiichi Higuchi; Stephen J Kennel
    Proceedings of the National Academy of Sciences of the United States of America, 108(34), E586-94, Aug. 2011リポジトリ電子ジャーナル
  • ApoA-I deficiency in mice is associated with redistribution of apoA-II and aggravated AApoAII amyloidosis.
    Yaoyong Wang; Jinko Sawashita; Jinze Qian; Beiru Zhang; Xiaoying Fu; Geng Tian; Lei Chen; Masayuki Mori; Keiichi Higuchi
    Journal of lipid research, 52(8), 1461-70, Aug. 2011リポジトリ電子ジャーナル
  • Amyloid fibrils formed by selective N- and C-terminal sequences of mouse apolipoprotein A-II
    J. Sawashita; F. Kametani; K. Hasegawa; M. Mori; H. Naiki; K. Higuchi
    AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 18(Suppl. 1), 19-21, Jun. 2011, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Genes for difference in eosinophilic phenotype between MES and BN.MES-Cyba(mes) rats are on chromosomes 9, 5, and 1.
    Hiroshi Tomozawa; Ayako Nishio; Keiichi Higuchi; Kiyoshi Matsumoto; Masayuki Mori
    Experimental animals, 60(2), 151-60, 2011リポジトリ
  • The reduced form of coenzyme Q10 mediates distinct effects on cholesterol metabolism at the transcriptional and metabolite level in SAMP1 mice.
    Constance Schmelzer; Jürgen G Okun; Dorothea Haas; Keiichi Higuchi; Jinko Sawashita; Masayuki Mori; Frank Döring
    IUBMB life, 62(11), 812-8, Nov. 2010リポジトリ電子ジャーナル
  • Quantitative trait locus on chromosome X affects bone loss after maturation in mice
    Shuzo Okudaira; Motoyuki Shimizu; Bungo Otsuki; Rika Nakanishi; Akira Ohta; Keiichi Higuchi; Masanori Hosokawa; Tadao Tsuboyama; Takashi Nakamura
    JOURNAL OF BONE AND MINERAL METABOLISM, 28(5), 520-531, Sep. 2010, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Exercise Effects on Methylation of ASC Gene
    Nakajima, K.; Takeoka, M.; Mori, M.; Hashimoto, S.; Sakurai, A.; Nose, H.; Higuchi, K.; Itano, N.; Shiohara, M.; Oh, T.; Taniguchi, S.
    INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 31(9), 671-675, Sep. 2010WebofScienceリポジトリ電子ジャーナル
  • Supplementation with the reduced form of Coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a peroxisome proliferator-activated receptor-alpha gene expression signature in SAMP1 mice.
    Constance Schmelzer; Hiroshi Kubo; Masayuki Mori; Jinko Sawashita; Mitsuaki Kitano; Kazunori Hosoe; Inka Boomgaarden; Frank Döring; Keiichi Higuchi
    Molecular nutrition & food research, 54(6), 805-15, Jun. 2010リポジトリ電子ジャーナル
  • Mouse model to study human A beta2M amyloidosis: generation of a transgenic mouse with excessive expression of human beta2-microglobulin.
    Pengyao Zhang; Xiaoying Fu; Jinko Sawashita; Junjie Yao; Beiru Zhang; Jinze Qian; Hiroshi Tomozawa; Masayuki Mori; Yukio Ando; Hironobu Naiki; Keiichi Higuchi
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 17(2), 50-62, Jun. 2010リポジトリ電子ジャーナル
  • Mouse senile amyloid fibrils deposited in skeletal muscle exhibit amyloidosis-enhancing activity.
    Jinze Qian; Jingmin Yan; Fengxia Ge; Beiru Zhang; Xiaoying Fu; Hiroshi Tomozawa; Jinko Sawashita; Masayuki Mori; Keiichi Higuchi
    PLoS pathogens, 6(5), e1000914, May 2010リポジトリ電子ジャーナル
  • Senile systemic amyloidosis in an aged savannah monkey (Cercopithecus aethiops) with tenosynovial degeneration.
    James Kenn Chambers; Takuya Kanda; Atsushi Shirai; Keiichi Higuchi; Shu-Ichi Ikeda; Yumi Une
    The Journal of veterinary medical science, 72(5), 657-9, May 2010リポジトリ
  • Vasopressin V1a receptor polymorphism and interval walking training effects in middle-aged and older people.
    Shizue Masuki; Masayuki Mori; Yasuharu Tabara; Tetsuro Miki; Akihiro Sakurai; Mayuko Morikawa; Ken Miyagawa; Keiichi Higuchi; Hiroshi Nose
    Hypertension (Dallas, Tex. : 1979), 55(3), 747-54, Mar. 2010リポジトリ電子ジャーナル
  • BN.MES-Cyba(mes) congenic rats manifest focal necrosis with eosinophilic infiltration in the liver without blood eosinophilia.
    Hiroshi Tomozawa; Ayako Nishio; Yuji Okuhara; Keiichi Higuchi; Kiyoshi Matsumoto; Masayuki Mori
    Experimental animals, 59(4), 469-78, 2010リポジトリ
  • Genetic basis of inter-individual variability in the effects of exercise on the alleviation of lifestyle-related diseases.
    Masayuki Mori; Keiichi Higuchi; Akihiro Sakurai; Yasuharu Tabara; Tetsuro Miki; Hiroshi Nose
    The Journal of physiology, 587(Pt 23), 5577-84, Dec. 2009リポジトリ電子ジャーナル
  • Amyloid fibrils formed by selective N-, C-terminal sequences of mouse apolipoprotein A-II.
    Jinko Sawashita; Fuyuki Kametani; Kazuhiro Hasegawa; Shinobu Tsutsumi-Yasuhara; Beiru Zhang; Jingmin Yan; Masayuki Mori; Hironobu Naiki; Keiichi Higuchi
    Biochimica et biophysica acta, 1794(10), 1517-29, Oct. 2009リポジトリ電子ジャーナル
  • Effects of mild calorie restriction and high-intensity interval walking in middle-aged and older overweight Japanese
    Sawashita, Jinko; Onitsuka, Sayaka; Gen-no, Hirokazu; Ishikawa, Shinobu; Iino, Fumie; Tateishi, Norihiko; Murakami, Takeo; Seki, Yoichi; Nagaiwa, Toshiyuki; Hanaoka, Masaaki; Hama, Sumio; Nose, Hiroshi; Higuchi, Keiichi
    EXPERIMENTAL GERONTOLOGY, 44(10), 666-675, Oct. 2009WebofScienceリポジトリ電子ジャーナル
  • Pivotal Advance: Eosinophilia in the MES rat strain is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba).
    Masayuki Mori; Guixin Li; Maiko Hashimoto; Ayako Nishio; Hiroshi Tomozawa; Nobuyoshi Suzuki; Shin-ichi Usami; Keiichi Higuchi; Kiyoshi Matsumoto
    Journal of leukocyte biology, 86(3), 473-8, Sep. 2009リポジトリ電子ジャーナル
  • Hereditary pancreatitis model WBN/Kob rat strain has a unique haplotype in the Pdwk1 region on chromosome 7.
    Masayuki Mori; Xiaoying Fu; Lei Chen; Guohong Zhang; Keiichi Higuchi
    Experimental animals, 58(4), 409-13, Jul. 2009リポジトリ
  • Dysfunction in ABCB1A has only a weak effect on susceptibility to dextran sulfate sodium-induced colitis in SAM strains.
    Guohong Zhang; Xiaoying Fu; Toshio Takeda; Keiichi Higuchi; Masayuki Mori
    Experimental animals, 58(4), 421-5, Jul. 2009リポジトリ
  • Effect of dietary unsaturated fatty acids on senile amyloidosis in senescence-accelerated mice.
    Makiko Umezawa; Keiichi Higuchi; Masayuki Mori; Takatoshi Matushita; Masanori Hosokawa
    The journals of gerontology. Series A, Biological sciences and medical sciences, 64(6), 646-52, Jun. 2009リポジトリ電子ジャーナル
  • Slaughtered aged cattle might be one dietary source exhibiting amyloid enhancing factor activity.
    Takuhiro Yoshida; Pengyao Zhang; Xiaoying Fu; Keiichi Higuchi; Shu-Ichi Ikeda
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 16(1), 25-31, Mar. 2009リポジトリ電子ジャーナル
  • Senescence-Accelerated Mouse (SAM) strains have a spontaneous mutation in the Abcb1a gene.
    Guohong Zhang; Beiru Zhang; Xiaoying Fu; Hiroshi Tomozawa; Kiyoshi Matsumoto; Keiichi Higuchi; Masayuki Mori
    Experimental animals, 57(4), 413-7, Jul. 2008リポジトリ
  • Fecal transmission of AA amyloidosis in the cheetah contributes to high incidence of disease.
    Beiru Zhang; Yumi Une; Xiaoying Fu; Jingmin Yan; FengXia Ge; Junjie Yao; Jinko Sawashita; Masayuki Mori; Hiroshi Tomozawa; Fuyuki Kametani; Keiichi Higuchi
    Proceedings of the National Academy of Sciences of the United States of America, 105(20), 7263-8, May 2008リポジトリ電子ジャーナル
  • Characterization of the cheetah serum amyloid A1 gene: critical role and functional polymorphism of a cis-acting element.
    Beiru Zhang; Yumi Une; Fengxia Ge; Xiaoying Fu; Jinze Qian; Pengyao Zhang; Jinko Sawashita; Keiichi Higuchi; Masayuki Mori
    The Journal of heredity, 99(4), 355-63, 2008リポジトリ電子ジャーナル
  • Amyloidosis in transgenic mice expressing murine amyloidogenic apolipoprotein A-II (Apoa2c).
    Fengxia Ge; Junjie Yao; Xiaoying Fu; Zhanjun Guo; Jingmin Yan; Beiru Zhang; Huanyu Zhang; Hiroshi Tomozawa; Junichi Miyazaki; Jinko Sawashita; Masayuki Mori; Keiichi Higuchi
    Laboratory investigation; a journal of technical methods and pathology, 87(7), 633-43, Jul. 2007リポジトリ
  • Cross-seeding and cross-competition in mouse apolipoprotein A-II amyloid fibrils and protein A amyloid fibrils.
    Jingmin Yan; Xiaoying Fu; Fengxia Ge; Beiru Zhang; Junjie Yao; Huanyu Zhang; Jinze Qian; Hiroshi Tomozawa; Hironobu Naiki; Jinko Sawashita; Masayuki Mori; Keiichi Higuchi
    The American journal of pathology, 171(1), 172-80, Jul. 2007リポジトリ
  • Quantitative trait locus that determines the cross-sectional shape of the femur in SAMP6 and SAMP2 mice.
    Bungo Otsuki; Takuro Matsumura; Motoyuki Shimizu; Masayuki Mori; Shuzo Okudaira; Rika Nakanishi; Keiichi Higuchi; Masanori Hosokawa; Tadao Tsuboyama; Takashi Nakamura
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 22(5), 675-85, May 2007リポジトリ
  • Apolipoprotein A-II accelerates reactive AA amyloidosis.
    Yang M, Liu Y, Li L, Miyahara H, Ding X, Dai J, Sawashita J, Mori M, Higuchi K.
    Amyloid, 24(sup1), 147-148, May 2007, Refereed電子ジャーナル
  • Functional polymorphisms of the Lss and Fdft1 genes in laboratory rats.
    Masayuki Mori; Jinko Sawashita; Keiichi Higuchi
    Experimental animals, 56(2), 93-101, Apr. 2007リポジトリ
  • Identification of differentially expressed genes in senescence-accelerated mouse testes by suppression subtractive hybridization analysis.
    Takuya Chiba; Junjie Yao; Yoshikazu Higami; Isao Shimokawa; Masanori Hosokawa; Keiichi Higuchi
    Mammalian genome : official journal of the International Mammalian Genome Society, 18(2), 105-12, Feb. 2007リポジトリ
  • Secreted frizzled-related protein 4 is a negative regulator of peak BMD in SAMP6 mice.
    Rika Nakanishi; Motoyuki Shimizu; Masayuki Mori; Haruhiko Akiyama; Shuzo Okudaira; Bungo Otsuki; Maiko Hashimoto; Keiichi Higuchi; Masanori Hosokawa; Tadao Tsuboyama; Takashi Nakamura
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 21(11), 1713-21, Nov. 2006リポジトリ
  • A third locus for Eosinophilia on chromosome 1 of the MES rats.
    Masayuki Mori; Keiichi Higuchi; Kiyoshi Matsumoto
    Experimental animals, 55(5), 497-500, Oct. 2006リポジトリ
  • Transmissibility of mouse AApoAII amyloid fibrils: inactivation by physical and chemical methods.
    Huanyu Zhang; Jinko Sawashita; Xiaoying Fu; Tatsumi Korenaga; Jingmin Yan; Masayuki Mori; Keiichi Higuchi
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 20(7), 1012-4, May 2006リポジトリ
  • Transmission of amyloidosis in offspring of mice with AApoAII amyloidosis.
    Tatsumi Korenaga; Jingmin Yan; Jinko Sawashita; Takatoshi Matsushita; Hironobu Naiki; Masanori Hosokawa; Masayuki Mori; Keiichi Higuchi; Xiaoying Fu
    The American journal of pathology, 168(3), 898-906, Mar. 2006リポジトリ
  • Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat.
    Masayuki Mori; Guixin Li; Ikuro Abe; Jun Nakayama; Zhanjun Guo; Jinko Sawashita; Tohru Ugawa; Shoko Nishizono; Tadao Serikawa; Keiichi Higuchi; Seigo Shumiya
    The Journal of clinical investigation, 116(2), 395-404, Feb. 2006リポジトリ
  • Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice.
    Jingmin Yan; Kenji Fujii; Junjie Yao; Hideyuki Kishida; Kazunori Hosoe; Jinko Sawashita; Toshio Takeda; Masayuki Mori; Keiichi Higuchi
    Experimental gerontology, 41(2), 130-40, Feb. 2006リポジトリ
  • A locus for eosinophilia in the MES rat is on Chromosome 19.
    Guixin Li; Zhanjun Guo; Keiichi Higuchi; Masatomo Kawakubo; Kiyoshi Matsumoto; Masayuki Mori
    Mammalian genome : official journal of the International Mammalian Genome Society, 16(7), 516-23, Jul. 2005リポジトリ
  • Unexpectedly high incidence of visceral AA-amyloidosis in slaughtered cattle in Japan.
    Kana Tojo; Takahiko Tokuda; Yoshinobu Hoshii; Xiaoying Fu; Keiichi Higuchi; Takane Matsui; Fuyuki Kametani; Shu-Ichi Ikeda
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 12(2), 103-8, Jun. 2005リポジトリ
  • Unexpected high incidence of visceral AA-amyloidosis in slaughtered cattle in Japan
    K Tojo; T Tokuda; Y Hoshii; XY Fu; K Higuchi; T Matsui; S Ikeda
    Prions: Food and Drug Safety, 12(2):103-8., 173-174, 2005, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Mouse testis transcriptome revealed using serial analysis of gene expression.
    Junjie Yao; Takuya Chiba; Jun Sakai; Kunitaka Hirose; Mikio Yamamoto; Akiyuki Hada; Kazunao Kuramoto; Keiichi Higuchi; Masayuki Mori
    Mammalian genome : official journal of the International Mammalian Genome Society, 15(6), 433-51, Jun. 2004リポジトリ
  • Deposition of transthyretin amyloid is not accelerated by the same amyloid in vivo.
    Lan Wei; Hiroo Kawano; Xiaoying Fu; Dan Cui; Sadahiro Ito; Ken-ichi Yamamura; Tokuhiro Ishihara; Takahiko Tokuda; Keiichi Higuchi; Shuichiro Maeda
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 11(2), 113-20, Jun. 2004リポジトリ
  • Tissue distribution, biochemical properties, and transmission of mouse type A AApoAII amyloid fibrils.
    Tatsumi Korenaga; Xiaoying Fu; Yanming Xing; Takatoshi Matsusita; Kazunao Kuramoto; Seigo Syumiya; Kazuhiro Hasegawa; Hironobu Naiki; Masaki Ueno; Tokuhiro Ishihara; Masanori Hosokawa; Masayuki Mori; Keiichi Higuchi
    The American journal of pathology, 164(5), 1597-606, May 2004リポジトリ
  • A patient with severe renal amyloidosis associated with an immunoglobulin gamma-heavy chain fragment.
    Masahide Yazaki; Tomohisa Fushimi; Takahiko Tokuda; Fuyuki Kametani; Kanji Yamamoto; Masayuki Matsuda; Hisashi Shimojo; Yoshinobu Hoshii; Kei-ichi Higuchi; Shu-ichi Ikeda
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 43(5), e23-8, May 2004リポジトリ
  • [Transmission of amyloidosis].
    Keiichi Higuchi
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 49(7 Suppl), 1101-4, May 2004リポジトリ
  • Induction of AApoAII amyloidosis by various heterogeneous amyloid fibrils.
    Xiaoying Fu; Tatsumi Korenaga; Li Fu; Yanming Xing; Zhanjun Guo; Takatoshi Matsushita; Masanori Hosokawa; Hironobu Naiki; Satoshi Baba; Yasushi Kawata; Shu-Ichi Ikeda; Tokuhiro Ishihara; Masayuki Mori; Keiichi Higuchi
    FEBS letters, 563(1-3), 179-84, Apr. 2004リポジトリ
  • Induction of AApoAII and AA amyloidosis by the injections of various amyloid fibrils
    Xiaoying Fu; Tatsumi Korenaga; Yanming Xing; L. Fu; Zhanjun Guo; Takatoshi Matsushita; Masanori Hosokawa; Hironobu Naiki; Masayuki Mori; Keiichi Higuchi
    International Congress Series, 1260(C), 383-386, Feb. 2004リポジトリ電子ジャーナル
  • Effects of dietary fats on senile amyloidosis in SAMP1 mice
    Makiko Umezawa; Harumi Okuyama; Masanori Hosokawa; Toshio Takeda; Keiichi Higuchi
    International Congress Series, 1260(C), 427-431, Feb. 2004リポジトリ電子ジャーナル
  • Genetic monitoring system for SAM strains utilizing DNA markers
    Masayuki Mori; Keiichi Higuchi
    International Congress Series, 1260(C), 187-190, Feb. 2004リポジトリ電子ジャーナル
  • Transmission of mouse AApoAII amyloidosis by the amyloid fibrils; inhibitory effects on transmission by the denaturation/degradation of amyloid fibrils
    Jinko Sawashita; Huanyu Zhang; Xiaoying Fu; Tatsumi Korenaga; Masayuki Mori; Keiichi Higuchi
    Amyloid and Amyloidosis, 457-459, Jan. 2004
  • Transmission of mouse AApoAII amyloidosis from mother to pups
    T. Korenaga; X. Fu; M. Mori; J. Sawashita; H. Naiki; T. Matsushita; K. Higuchi
    Amyloid and Amyloidosis, 460-462, Jan. 2004
  • Paraneoplastic sensorimotor neuropathy and encephalopathy associated with anti-alpha-enolase antibody in a case of gastric adenocarcinoma
    K Tojo; T Tokuda; M Yazaki; T Oide; A Nakamura; S Mitsuhashi; K Kaneko; K Maruyama; F Kametani; K Higuchi; S Ikeda
    EUROPEAN NEUROLOGY, 51(4), 231-233, 2004, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Spontaneous hypomorphic mutations in antioxidant enzymes of mice.
    Zhanjun Guo; Keiichi Higuchi; Masayuki Mori
    Free radical biology & medicine, 35(12), 1645-52, Dec. 2003リポジトリ
  • Polymorphisms of mouse apolipoprotein A-II: seven alleles found among 41 inbred strains of mice.
    Kaori Kitagawa; Jing Wang; Takatoshi Mastushita; Kumiko Kogishi; Masanori Hosokawa; Xiaoying Fu; Zhanjun Guo; Masayuki Mori; Keiichi Higuchi
    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 10(4), 207-14, Dec. 2003リポジトリ
  • Amyloidosis modifier genes in the less amyloidogenic a/j mouse strain.
    Zhanjun Guo; Masayuki Mori; Xiaoying Fu; Junjie Yao; Yanming Xing; Tatsumi Korenaga; Guixin Li; Takatoshi Matsushita; Masanori Hosokawa; Keiichi Higuchi
    Laboratory investigation; a journal of technical methods and pathology, 83(11), 1605-13, Nov. 2003リポジトリ
  • Dietary fat modulation of apoA-II metabolism and prevention of senile amyloidosis in the senescence- accelerated mouse.
    Makiko Umezawa; Kenjiro Tatematsu; Tatsumi Korenaga; Xiaoying Fu; Takatoshi Matushita; Harumi Okuyama; Masanori Hosokawa; Toshio Takeda; Keiichi Higuchi
    Journal of lipid research, 44(4), 762-9, Apr. 2003リポジトリ
  • A new beige mutant rat ACI/N-Lystbg-Kyo.
    Masayuki Mori; Ken-ichi Yamasaki; Satoshi Nakanishi; Kazuhiro Kitada; Keiichi Higuchi; Chiaki Namiki; Shuichi Hamada; Tadao Serikawa
    Experimental animals, 52(1), 31-6, Jan. 2003リポジトリ
  • Diurnal rhythm disorder of behavioral activity in SAMP1 mice is partially normalized by spontaneous wheel running.
    Yanagidaira, Y; Higuchi, K; Nose, H
    PHYSIOLOGY&BEHAVIOR, 80(2-3), 195-201, 2003WebofScience電子ジャーナル
  • Amyloid fibril proteins.
    Yanming Xing; Keiichi Higuchi
    Mechanisms of ageing and development, 123(12), 1625-36, Nov. 2002リポジトリ
  • Induction of protein conformational change in mouse senile amyloidosis.
    Yanming Xing; Akihiro Nakamura; Tatsumi Korenaga; Zhanjun Guo; Junjie Yao; Xiaoying Fu; Takatoshi Matsushita; Kumiko Kogishi; Masanori Hosokawa; Fuyuki Kametani; Masayuki Mori; Keiichi Higuchi
    The Journal of biological chemistry, 277(36), 33164-9, Sep. 2002リポジトリ
  • A congenic mouse and candidate gene at the Chromosome 13 locus regulating bone density.
    Motoyuki Shimizu; Keiichi Higuchi; Soichiro Kasai; Tadao Tsuboyama; Mutsumi Matsushita; Takuro Matsumura; Shuzo Okudaira; Masayuki Mori; Akio Koizumi; Takashi Nakamura; Masanori Hosokawa
    Mammalian genome : official journal of the International Mammalian Genome Society, 13(7), 335-40, Jul. 2002リポジトリ
  • Glial fibrillary acidic protein is greatly modified by oxidative stress in aceruloplasminemia brain
    K Kaneko; A Nakamura; K Yoshida; F Kametani; K Higuchi; SI Ikeda
    FREE RADICAL RESEARCH, 36(3), 303-306, Mar. 2002, Refereed, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Deterioration in learning and memory of inferential tasks for evaluation of transitivity and symmetry in aged SAMP8 mice.
    Akira Ohta; Ichiro Akiguchi; Naoyuki Seriu; Katsunori Ohnishi; Hideo Yagi; Keiichi Higuchi; Masanori Hosokawa
    Hippocampus, 12(6), 803-10, 2002リポジトリ
  • Extrahepatic expression of apolipoprotein A-II in mouse tissues: Possible contribution to mouse senile amyloidosis
    L Fu; Matsuyama, I; T Chiba; YM Xing; T Korenaga; ZJ Guo; XY Fu; J Nakayama; M Mori; K Higuchi
    JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 49(6), 739-747, Jun. 2001, Not invitedWebofScienceリポジトリ
  • Spontaneous loss-of-function mutations of the 8-oxoguanine DNA glycosylase gene in mice and exploration of the possible implication of the gene in senescence
    Masayuki Mori; Shinya Toyokuni; Shohei Kondo; Hiroshi Kasai; Hironobu Naiki; Eiko Toichi; Masanori Hosokawa; Keiichi Higuchi
    Free Radical Biology and Medicine, 30(10), 1130-1136, May 2001リポジトリ電子ジャーナル
  • Transmission of mouse senile amyloidosis
    Yanming Xing; Akihiro Nakamura; Takuya Chiba; Kumiko Kogishi; Takatoshi Matsushita; Fu Li; Zhanjun Guo; Masanori Hosokawa; Masayuki Mori; Keiichi Higuchi
    Laboratory Investigation, 81(4), 493-499, 2001リポジトリ電子ジャーナル
  • Deterioration in learning and memory of fear conditioning in response to context in aged SAMP8 mice
    Akira Ohta; Ichiro Akiguchi; Naoyuki Seriu; Katsunori Ohnishi; Hideo Yagi; Keiichi Higuchi; Masanori Hosokawa
    Neurobiology of Aging, 22(3), 479-484, 2001リポジトリ電子ジャーナル
  • Unique mutations in mitochondrial DNA of senescence-accelerated mouse (SAM) strains
    J. Mizutani; T. Chiba; M. Tanaka; K. Higuchi; Masayuki Mori
    Journal of Heredity, 92(4), 352-355, 2001リポジトリ電子ジャーナル
  • Chromosome 13 locus, Pbd2, regulates bone density in mice
    Motoyuki Shimizu; Keiichi Higuchi; Soichiro Kasai; Tadao Tsuboyama; Mutsumi Matsushita; Masayuki Mori; Yasuhiko Shimizu; Takashi Nakamura; Masanori Hosokawa
    Journal of Bone and Mineral Research, 16(11), 1972-1982, 2001リポジトリ電子ジャーナル
  • Senile ocular amyloidosis in SAM and BALB/c strains of mice
    Masato Shoji; Takatoshi Matsushita; Keiichi Higuchi; Yoshihito Honda; Masanori Hosokawa
    Mechanisms of Ageing and Development, 120(1-3), 87-94, Dec. 2000リポジトリ電子ジャーナル
  • Genetic analysis of lifespan in hybrid progeny derived from the SAMP1 mouse strain with accelerated senescence
    Zhanjun Guo; Eiko Toichi; Masamichi Hosono; Tomohide Hosokawa; Masanori Hosokawa; Keiichi Higuchi; Masayuki Mori
    Mechanisms of Ageing and Development, 118(1-2), 35-44, Sep. 2000リポジトリ電子ジャーナル
  • Cardiac amyloid in patients with familial amyloid polyneuropathy consists of abundant wild-type transthyretin.
    M Yazaki; T Tokuda; A Nakamura; T Higashikata; J Koyama; K Higuchi; Y Harihara; S Baba; F Kametani; S Ikeda
    Biochemical and biophysical research communications, 274(3), 702-6, Aug. 2000リポジトリ
  • Tubular aggregates in the skeletal muscle of the senescence-accelerated mouse; SAM.
    T Nishikawa; J A Takahashi; T Matsushita; K Ohnishi; K Higuchi; N Hashimoto; M Hosokawa
    Mechanisms of ageing and development, 114(2), 89-99, Mar. 2000リポジトリ
  • Serum lipid concentrations and mean life span are modulated by dietary polyunsaturated fatty acids in the senescence-accelerated mouse.
    M Umezawa; T Takeda; K Kogishi; K Higuchi; T Matushita; J Wang; T Chiba; M Hosokawa
    The Journal of nutrition, 130(2), 221-7, Feb. 2000リポジトリ
  • Wild type ApoA-II gene does not rescue senescence-accelerated mouse (SAMP1) from short life span and accelerated mortality
    J. Wang; T. Matsushita; K. Kogishi; C. Xia; A. Ohta; T. Chiba; A. Nakamura; H. Kondo; M. Mori; M. Hosokawa; K. Higuchi
    Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 55(9), B432-B439, 2000リポジトリ電子ジャーナル
  • Deletion in the beige gene of the beige rat owing to recombination between LINE1s.
    M Mori; T Nishikawa; K Higuchi; M Nishimura
    Mammalian genome : official journal of the International Mammalian Genome Society, 10(7), 692-5, Jul. 1999リポジトリ
  • Aminoguanidine supplementation delays the onset of senescence in vitro in dermal fibroblast-like cells from senescence-accelerated mice.
    H Fujisawa; T Nishikawa; B H Zhu; Y Nishimura; M Shimizu; M Kimoto; K Higuchi; M Hosokawa
    The journals of gerontology. Series A, Biological sciences and medical sciences, 54(7), B276-82, Jul. 1999リポジトリ
  • Expression of the c-fos gene induced by parathyroid hormone in the bones of SAMP6 mice, a murine model for senile osteoporosis
    Norikazu Takeda; Tadao Tsuboyama; Ryuichi Kasai; Kenshirou Takahashi; Motoyuki Shimizu; Takashi Nakamura; Keiichi Higuchi; Masanori Hosokawa
    Mechanisms of Ageing and Development, 108(1), 87-97, Apr. 1999リポジトリ電子ジャーナル
  • Genetic typing of the senescence-accelerated mouse (SAM) strains with microsatellite markers.
    C Xia; K Higuchi; M Shimizu; T Matsushita; K Kogishi; J Wang; T Chiba; M F Festing; M Hosokawa
    Mammalian genome : official journal of the International Mammalian Genome Society, 10(3), 235-8, Mar. 1999リポジトリ
  • Senescence-accelerated mouse.
    K Higuchi; M Hosokawa; T Takeda
    Methods in enzymology, 309, 674-86, 1999リポジトリ
  • Mouse senile amyloid deposition is suppressed by adenovirus-mediated overexpression of amyloid-resistant apolipoprotein A-II
    Takuya Chiba; Kumiko Kogishi; Jing Wang; Cher Xia; Takatoshi Matsushita; Jun-Ichi Miyazaki; Izumu Saito; Masanori Hosokawa; Keiichi Higuchi
    American Journal of Pathology, 155(4), 1319-1326, 1999, Refereed, Not invitedリポジトリ電子ジャーナル
  • Fibrilization in mouse senile amyloidosis is fibril conformation-dependent.
    K Higuchi; K Kogishi; J Wang; X Chen; T Chiba; T Matsushita; Y Hoshii; H Kawano; T Ishihara; T Yokota; M Hosokawa
    Laboratory investigation; a journal of technical methods and pathology, 78(12), 1535-42, Dec. 1998リポジトリ
  • Age-related changes in the brains of senescence-accelerated mice (SAM): association with glial and endothelial reactions.
    T Kawamata; I Akiguchi; K Maeda; C Tanaka; K Higuchi; M Hosokawa; T Takeda
    Microscopy research and technique, 43(1), 59-67, Oct. 1998リポジトリ
  • An early stage mechanism of the age-associated mitochondrial dysfunction in the brain of SAMP8 mice; an age-associated neurodegeneration animal model.
    T Nishikawa; J A Takahashi; Y Fujibayashi; H Fujisawa; B Zhu; Y Nishimura; K Ohnishi; K Higuchi; N Hashimoto; M Hosokawa
    Neuroscience letters, 254(2), 69-72, Sep. 1998リポジトリ
  • Ultrastructural and permeability features of microvessels in the olfactory bulbs of SAM mice.
    M Ueno; I Akiguchi; M Hosokawa; M Shinnou; H Sakamoto; M Takemura; K Higuchi
    Acta neuropathologica, 96(3), 261-70, Sep. 1998リポジトリ
  • Age-related changes in blood pressure in the senescence-accelerated mouse (SAM): aged SAMP1 mice manifest hypertensive vascular disease.
    J Han; M Hosokawa; M Umezawa; H Yagi; T Matsushita; K Higuchi; T Takeda
    Laboratory animal science, 48(3), 256-63, Jun. 1998リポジトリ
  • Accelerated aging of dermal fibroblast-like cells from the senescence-accelerated mouse (SAM): acceleration of changes in DNA ploidy associated with in vitro cellular aging.
    H Fujisawa; T Nishikawa; B H Zhu; N Takeda; H Jujo; K Higuchi; M Hosokawa
    The journals of gerontology. Series A, Biological sciences and medical sciences, 53(1), B11-7, Jan. 1998, Refereed, Not invitedリポジトリ
  • A morphological and morphometrical study of the retina in aging SAM mice.
    M Shoji; M Okada; A Ohta; K Higuchi; M Hosokawa; Y Honda
    Ophthalmic research, 30(3), 172-9, 1998リポジトリ
  • Amyloid A protein amyloidosis induced in apolipoprotein-E-deficient mice.
    Y Hoshii; H Kawano; D Cui; T Takeda; T Gondo; M Takahashi; K Kogishi; K Higuchi; T Ishihara
    The American journal of pathology, 151(4), 911-7, Oct. 1997リポジトリ
  • Accumulation of pro-apolipoprotein A-II in mouse senile amyloid fibrils.
    K Higuchi; K Kogishi; J Wang; C Xia; T Chiba; T Matsushita; M Hosokawa
    The Biochemical journal, 325 ( Pt 3)(Pt 3), 653-9, Aug. 1997リポジトリ
  • Neuropathological studies on strains of Senescence-Accelerated mice (SAM) with age-related deficits in learning and memory
    T Kawamata; Akiguchi, I; H Yagi; M Irino; H Sugiyama; H Akiyama; A Shimada; M Takemura; M Ueno; T Kitabayashi; K Ohnishi; N Seriu; K Higuchi; M Hosokawa; T Takeda
    EXPERIMENTAL GERONTOLOGY, 32(1-2), 161-169, Jan. 1997, Not invitedWebofScienceリポジトリ電子ジャーナル
  • Management and design of the maintenance of SAM mouse strains: An animal model for accelerated senescence and age-associated disorders
    Masanori Hosokawa; Abe Toshio; Keiichi Higuchi; Kozo Shimakawa; Yoshiaki Omori; Takatoshi Matsushita; Kumiko Kogishi; Eishi Deguchi; Yoshiko Kishimoto; Kuraichi Yasuoka; Toshio Takeda
    Experimental Gerontology, 32(1-2), 111-116, 1997リポジトリ電子ジャーナル
  • Inheritance and strain distribution of a persistent hyaloid vascular system in mice
    Hiromi Fujisawa; Naoyuki Seriu; Bing-Hua Zhu; Keiichi Higuchi; Masanori Hosokawa
    Experimental Eye Research, 64(4), 553-558, 1997リポジトリ電子ジャーナル
  • Age-related changes in barrier function in mouse brain II, Accumulation of serum albumin in the olfactory bulb of SAM mice increased with aging
    UENO Masaki; AKIGUCHI Ichiro; HOSOKAWA Masanori; SHINNOU Masahiko; SAKAMOTO Haruhiko; TAKEMURA Manabu; HIGUCHI Keiichi
    Arch. Geront. Geriatr., 25/,321-331, 321-331, 1997, Refereed, Not invitedリポジトリ電子ジャーナル
  • Age-related changes in the brain transfer of blood-borne horseradish peroxidase in the hipocampus of senescence-accelerated mouse
    UENO Masaki; AKIGUCHI Ichiro; HOSOKAWA Masanori; SHINNOU Masahiko; SAKAMOTO Haruhiko; TAKEMURA Manabu; HIGUCHI Keiichi
    Acta Neuropathol, 93, 233, 1997, Refereed, Not invitedリポジトリ電子ジャーナル
  • Senescence-accelerated Mouse (SAM): With Special Reference to Development and Pathological Phenotypes.
    Toshio Takeda; Keiichi Higuchi; Masanori Hosokawa
    ILAR journal, 38(3), 109-118, 1997リポジトリ
  • Immunohistochemical study with anti-advanced glycation end-products antibody in murine amyloidosis.
    Y Hoshii; H Kawano; T Gondo; M Takahashi; T Ishihara; K Higuchi; S Horiuchi
    Pathology international, 46(10), 738-42, Oct. 1996リポジトリ
  • Accelerated senile amyloidosis induced by amyloidogenic ApoA-II gene shortens the life span of mice but does not accelerate the rate of senescence
    Keiichi Higuchi; Jing Wang; Kaori Kitagawa; Takatoshi Matsushita; Kumiko Kogishi; Hironobu Naiki; Haruo Kitado; Masanori Hosokawa
    Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 51(4), B295-B302, 1996リポジトリ電子ジャーナル
  • THE FIRST INTERNATIONAL-CONFERENCE ON SENESCENCE - THE SAM MODEL - KYOTO, JAPAN, 1994
    K HIGUCHI; A SHIMADA; M HOSOKAWA; T TAKEDA
    AMYLOID-INTERNATIONAL JOURNAL OF EXPERIMENTAL AND CLINICAL INVESTIGATION, 2(2), 134-138, Jun. 1995, Not invitedWebofScienceリポジトリ
  • Apolipoprotein A-II gene and development of amyloidosis and senescence in a congenic strain of mice carrying amyloidogenic ApoA-II
    K. Higuchi; H. Naiki; K. Kitagawa; H. Kitado; K. Kogishi; T. Matsushita; T. Takeda
    Laboratory Investigation, 72(1), 75-82, 1995リポジトリ
  • Age-associated decreases in the messenger ribonucleic acid level and the rate of synthesis of apolipoprotein A-II in murine senile amyloidosis
    K. Kitagawa; H. Naiki; T. Takeda; K. Higuchi
    Laboratory Investigation, 70(4), 565-571, 1994リポジトリ
  • GENETIC-ANALYSIS OF MURINE SENILE AMYLOIDOSIS
    H NAIKI; K HIGUCHI; A SHIMADA; T TAKEDA; K NAKAKUKI
    LABORATORY INVESTIGATION, 68(3), 332-337, Mar. 1993, Not invitedWebofScienceリポジトリ
  • Development of congenic strains of mice carrying amyloidogenic apolipoprotein A-II (Apoa2c). Apoa2c reduces the plasma level and the size of high density lipoprotein
    Keiichi Higuchi; Haruo Kitado; Kaori Kitagawa; Kumiko Kogishi; Hironobu Naiki; Toshio Takeda
    FEBS Letters, 317(3), 207-210, Feb. 1993リポジトリ電子ジャーナル
  • Mouse senile amyloidosis - ASSAM amyloidosis in mice presents universally as a systemic age-associated amyloidosis
    K. Higuchi; H. Naiki; K. Kitagawa; M. Hosokawa; T. Takeda
    Virchows Archiv B Cell Pathology Including Molecular Pathology, 60(1), 231-238, Dec. 1991リポジトリ電子ジャーナル
  • Polymorphism of apolipoprotein A-II (apoA-II) among inbred strains of mice. Relationship between the molecular type of apoA-II and mouse senile amyloidosis
    K. Higuchi; K. Kitagawa; H. Naiki; K. Hanada; M. Hosokawa; T. Takeda
    Biochemical Journal, 279(2), 427-433, 1991リポジトリ電子ジャーナル
  • FLUOROMETRIC EXAMINATION OF TISSUE AMYLOID FIBRILS IN MURINE SENILE AMYLOIDOSIS - USE OF THE FLUORESCENT INDICATOR, THIOFLAVINE-T
    H NAIKI; K HIGUCHI; K KITAGAWA; A SHIMADA; WH CHEN; M HOSOKAWA; K NAKAKUKI; T TAKEDA
    AMYLOID AND AMYLOIDOSIS 1990, 393-396, 1991, Refereed, Not invitedWebofScienceリポジトリ
  • METHODS IN LABORATORY INVESTIGATION - FLUOROMETRIC EXAMINATION OF TISSUE AMYLOID FIBRILS IN MURINE SENILE AMYLOIDOSIS - USE OF THE FLUORESCENT INDICATOR, THIOFLAVINE-T
    H NAIKI; K HIGUCHI; K MATSUSHIMA; A SHIMADA; WH CHEN; M HOSOKAWA; T TAKEDA
    LABORATORY INVESTIGATION, 62(6), 768-773, Jun. 1990, Not invitedWebofScienceリポジトリ
  • Homozygous hypobetalipoproteinemia: transcriptional regulation and 5′-flanking sequence analysis in an apolipoprotein B deficiency state
    Robert S. Ross; Jeffrey M. Hoeg; Keiichi Higuchi; Uwe K. Schumacher; Silvia Fojo; Richard E. Gregg; H. Bryan Brewer
    Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1004(1), 29-35, Jul. 1989リポジトリ電子ジャーナル
  • Expression of apolipoprotein B mRNAs encoding higher- and lower-molecular weight isoproteins in rat liver and intestine.
    G E Tennyson; C A Sabatos; K Higuchi; N Meglin; H B Brewer
    Proceedings of the National Academy of Sciences, 86(2), 500-504, Jan. 1989, Refereedリポジトリ電子ジャーナル
  • Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavine T
    Hironobu Naiki; Keiichi Higuchi; Masanori Hosokawa; Toshio Takeda
    Analytical Biochemistry, 177(2), 244-249, 1989リポジトリ電子ジャーナル
  • Donor splice site mutation in the apolipoprotein (Apo) C-II gene (Apo C-IIHamburg) of a patient with Apo C-II deficiency.
    S S Fojo; U Beisiegel; U Beil; K Higuchi; M Bojanovski; R E Gregg; H Greten; H B Brewer
    Journal of Clinical Investigation, 82(5), 1489-1494, Nov. 1988, Refereedリポジトリ電子ジャーナル
  • Apolipoprotein C-II deficiency: Identification of a structural variant apoC-IIPadova
    Silvia S. Fojo; Giovanella Baggio; Carlo Gabelli; Kayoko Higuchi; Marina Bojanovski; Richard E. Gregg; H.Bryan Brewer
    Biochemical and Biophysical Research Communications, 154(1), 73-79, Jul. 1988リポジトリ電子ジャーナル
  • Human apolipoprotein B (apoB) mRNA: identification of two distinct apoB mRNAs, an mRNA with the apoB-100 sequence and an apoB mRNA containing a premature in-frame translational stop codon, in both liver and intestine.
    K Higuchi; A V Hospattankar; S W Law; N Meglin; J Cortright; H B Brewer
    Proceedings of the National Academy of Sciences, 85(6), 1772-1776, Mar. 1988, Refereed
    Leadリポジトリ電子ジャーナル
  • Homozygous hypobetalipoproteinemia: a disease distinct from abetalipoproproteinemia at the molecular level.
    R S Ross; R E Gregg; S W Law; J C Monge; S M Grant; K Higuchi; T J Triche; J Jefferson; H B Brewer
    Journal of Clinical Investigation, 81(2), 590-595, Feb. 1988, Refereedリポジトリ電子ジャーナル
  • Immune responses in newly developed short-lived SAM mice. I. Age-associated early decline in immune activities of cultured spleen cells.
    Hosokawa T; Hosono M; Higuchi K; Aoike A; Kawai K; Takeda T
    Immunology., 62(3), 419-423, Nov. 1987, Refereed
  • Identification of a novel in-frame translational stop codon in human intestine ApoB mRNA
    Ashok V. Hospattankar; Keiichi Higuchi; Simon W. Law; Nancy Meglin; H.Bryan Brewer
    Biochemical and Biophysical Research Communications, 148(1), 279-285, Oct. 1987リポジトリ電子ジャーナル
  • A molecular-pathologic approach to murine senile amyloidosis. Serum precursor-apolipoprotein A-II variant (Pro5----Gln) presents only in the senile amyloidosis-prone SAM-P/1 and SAM-P/2 mice.
    Yonezu T; Tsunasawa S; Higuchi K; Kogishi K; Naiki H; Hanada K; Sakiyama F; Takeda T
    Lab Invest., 57(1), 65-70, Jul. 1987, Refereed
    Corresponding
  • The human apoB-100 gene: ApoB-100 is encoded by a single copy gene in the human genome
    K. Higuchi; J.C. Monge; N. Lee; S.W. Law; H.B. Brewer; A.Y. Sakaguchi; S.L. Naylor
    Biochemical and Biophysical Research Communications, 144(3), 1332-1339, May 1987, Refereed
    Leadリポジトリ電子ジャーナル
  • Age-related changes in bone mass in the senescence-accelerated mouse (SAM). SAM-R/3 and SAM-P/6 as new murine models for senile osteoporosis.
    Matsushita M; Tsuboyama T; Kasai R; Okumura H; Yamamuro T; Higuchi K; Higuchi K; Kohno A; Yonezu T; Utani A; Umezawa M; Takeda T.
    Am J Pathol, 125(2), 276-283, Nov. 1986, Refereed
  • Human liver apolipoprotein B-100 cDNA: complete nucleic acid and derived amino acid sequence.
    S W Law; S M Grant; K Higuchi; A Hospattankar; K Lackner; N Lee; H B Brewer
    Proceedings of the National Academy of Sciences, 83(21), 8142-8146, Nov. 1986リポジトリ電子ジャーナル
  • The single proline-glutamine substitution at position 5 enhances the potency of amyloid fibril formation of murine apo A-II
    Keiichi Higuchi; Tomonori Yonezu; Susumu Tsunasawa; Fumio Sakiyama; Toshio Takeda
    FEBS Letters, 207(1), 23-27, Oct. 1986, Refereed
    Correspondingリポジトリ電子ジャーナル
  • Purification and characterization of a senile amyloid-related antigenic substance (apoSASSAM) from mouse serum. apoSASSAM is an apoA-II apolipoprotein of mouse high density lipoproteins.
    Higuchi K; Yonezu T; Kogishi K; Matsumura A; Takeshita S; Higuchi K; Kohno A; Matsushita M; Hosokawa M; Takeda T
    Journal of Biological Chemistry, 261(27), 12834-12840, Sep. 1986, Refereed
    Leadリポジトリ電子ジャーナル
  • High homology is present in the primary structures between murine senile amyloid protein (ASSAM) and human apolipoprotein A-II
    Tomonori Yonezu; Keiichi Higuchi; Susumu Tsunasawa; Shigeyuki Takagi; Fumio Sakiyama; Toshio Takeda
    FEBS Letters, 203(2), 149-152, Jul. 1986, Refereedリポジトリ電子ジャーナル
  • Molecular cloning and nucleotide sequence of cDNA for murine senile amyloid protein: nucleotide substitutions found in apolipoprotein A-II cDNA of senescence accelerated mouse (SAM)
    Takahiro Kunisada; Keiichi Higuchi; Shin-ichi Aota; Toshio Takeda; Hideo Yamagishi
    Nucleic Acids Research, 14(14), 5729-5740, 1986リポジトリ電子ジャーナル
  • Morphologic demonstration of cytoplasmic ASSAM-related antigenic substance (CASSAM) by an immunoperoxidase technique
    Takeshita S; Higuchi K; Hosokawa M; Matsumura A; Higuchi K; Kohno A; Matsushita M; Yonezu T; Takeda T
    Am J Pathol, 121(3), 455-465, Dec. 1985, Refereed
    Corresponding
  • Chronic Food Restriction Modulates the Advance of Senescence in the Senescence Accelerated Mouse (SAM)
    Atsuko Kohno; Tomonori Yonezu; Mutsumi Matsushita; Mika Irino; Keiichi Higuchi; Kayoko Higuchi; Shuji Takeshita; Masanori Hosokawa; Toshio Takeda
    The Journal of Nutrition, 115(10), 1259-1266, Oct. 1985リポジトリ電子ジャーナル
  • Age-related changes of serum apoprotein SASSAM, apoprotein A-I and low-density lipoprotein levels in senescence accelerated mouse (SAM)
    Keiichi Higuchi; Atsuko Matsumura; Atsuko Honma; Kayoko Toda; Shuji Takeshita; Mutsumi Matsushita; Tomonori Yonezu; Masanori Hosokawa; Toshio Takeda
    Mechanisms of Ageing and Development, 26(2-3), 311-326, Aug. 1984リポジトリ電子ジャーナル
  • Grading score system: A method for evaluation of the degree of senescence in Senescence Accelerated Mouse (SAM)
    Masanori Hosokawa; Ryuichi Kasai; Keiichi Higuchi; Shuji Takeshita; Katsuji Shimizu; Hajime Hamamoto; Atsuko Honma; Mika Irino; Kayoko Toda; Atsuko Matsumura; Mutsumi Matsushita; Toshio Takeda
    Mechanisms of Ageing and Development, 26(1), 91-102, Jul. 1984リポジトリ電子ジャーナル
  • Cataract and other ophthalmic lesions in senescence accelerated mouse (SAM). Morphology and incidence of senescence associated ophthalmic changes in mice
    Masanori Hosokawa; Shuji Takeshita; Keiichi Higuchi; Katsuji Shimizu; Irino Mika; Kayoko Toda; Atsuko Honma; Atsuko Matsumura; Kimio Yasuhira; Toshio Takeda
    Experimental Eye Research, 38(2), 105-114, Feb. 1984リポジトリ電子ジャーナル
  • Isolation and characterization of senile amyloid--related antigenic substance (SASSAM) from mouse serum. Apo SASSAM is a low molecular weight apoprotein of high density lipoprotein.
    K Higuchi; A Matsumura; K Hashimoto; A Honma; S Takeshita; M Hosokawa; K Yasuhira; T Takeda
    Journal of Experimental Medicine, 158(5), 1600-1614, Nov. 1983リポジトリ電子ジャーナル
  • Systemic senile amyloid in senescence-accelerated mice. A unique fibril protein demonstrated in tissues from various organs by the unlabeled immunoperoxidase method.
    Higuchi K; Matsumura A; Honma A; Takeshita S; Hashimoto K; Hosokawa M; Yasuhira K; Takeda T
    Lab Invest, 48(2), 231-240, Feb. 1983, Refereed
    Lead
  • Spontaneous age-associated amyloidosis in senescence-accelerated mouse (SAM)
    Shuji Takeshita; Masanori Hosokawa; Mika Irino; Keiichi Higuchi; Katsuji Shimizu; Kimio Yasuhira; Toshio Takeda
    Mechanisms of Ageing and Development, 20(1), 13-23, Sep. 1982リポジトリ電子ジャーナル
  • A new murine model of accelerated senescence
    T TAKEDA; M HOSOKAWA; S TAKESHITA; M IRINO; K HIGUCHI; T MATSUSHITA; Y TOMITA; K YASUHIRA; H HAMAMOTO; K SHIMIZU
    Mechanisms of Ageing and Development, 17(2), 183-194, Oct. 1981リポジトリ電子ジャーナル

MISC

  • 最先端医療の今 プロテオミクスに基づく加齢性アミロイドーシスの抑制機構
    宮原 大貴; 矢崎 正英; 樋口 京一
    Medical Science Digest, 49(13), 708 - 709, Dec. 2023
  • 【proteinopathy最前線】アミロイドーシス
    樋口 京一
    BIO Clinica, 38(3), 224 - 228, Mar. 2023
  • コプロポルフィリノーゲン酸化酵素遺伝子変異マウスは心筋変性を呈する
    亢 暁静; 森 政之; 代 健; 宮原 大貴; 劉 暢; 五十嵐 佑一; 崔 小冉; 李 瑩; 樋口 京一
    血管, 44(1), 62 - 62, Jun. 2021
  • 山なみのはるかに
    樋口 京一
    信州医学雑誌, 69(1), 11 - 13, Feb. 2021リポジトリ
  • 【2025年問題を見据えたエージング研究と医薬品開発】老化モデル動物を用いたエージング研究
    樋口 京一; 森 政之
    ファルマシア, 56(11), 1004 - 1008, Nov. 2020
    https://search.jamas.or.jp/default/link?pub_year=2020&ichushi_jid=J01316&link_issn=&doc_id=20201105210004&doc_link_id=10.14894%2Ffaruawpsj.56.11_1004&url=https%3A%2F%2Fdoi.org%2F10.14894%2Ffaruawpsj.56.11_1004&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gifリポジトリ
  • 創薬シリーズ 創薬研究の新潮流 老化研究のためのモデルマウス 老化促進モデルマウスを軸にして
    森 政之; 樋口 京一
    日本薬理学雑誌, 153(4), 179 - 185, Apr. 2019
    https://search.jamas.or.jp/default/link?pub_year=2019&ichushi_jid=J01200&link_issn=&doc_id=20190411560006&doc_link_id=1390282763106577536&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390282763106577536&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_3.gifリポジトリ
  • 【認知症におけるタンパク質伝播について議論する】全身性アミロイドーシスの伝播
    樋口 京一
    Dementia Japan, 33(1), 23 - 30, Jan. 2019リポジトリ
  • 認知症におけるタンパク質伝播について議論する 全身性アミロイドーシスの伝播
    樋口 京一; 澤下 仁子
    Dementia Japan, 31(4), 512 - 512, Oct. 2017
  • 【アミロイドーシスの最新情報】アミロイドーシスの基礎的知識 全身性アミロイドーシスの疾患感受性と個体間伝播
    樋口 京一; 澤下 仁子
    医学のあゆみ, 258(6), 621 - 627, Aug. 2016
    https://search.jamas.or.jp/default/link?pub_year=2016&ichushi_jid=J00060&link_issn=&doc_id=20160809030004&doc_link_id=%2Faa7ayuma%2F2016%2F025806%2F005%2F0621-0627%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Faa7ayuma%2F2016%2F025806%2F005%2F0621-0627%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gifリポジトリ
  • 日本人研究者の発見 アミロイドーシスの伝播と神経系 アミロイドーシス伝播の動物モデル
    樋口 京一
    NEUROINFECTION, 21(1), 80 - 87, Apr. 2016
  • アミロイド線維の伝播とアミロイドーシスの発症
    樋口 京一
    臨床検査学教育, 8(1), 20 - 26, Mar. 2016リポジトリ
  • 【神経変性疾患への新しい視点-プリオン仮説】"感染性"アミロイドーシス AApoA IIアミロイドーシス
    樋口 京一
    Clinical Neuroscience, 33(3), 337 - 341, Mar. 2015
  • 【伝播する蛋白質:プリオノイド仮説】アミロイド
    樋口 京一; 池田 修一
    神経内科, 81(6), 602 - 609, Dec. 2014リポジトリ
  • 老化の生物モデルを縦横に斬り、考える!
    三井 洋司; 樋口 京一; 森 政之; 石井 直明; 重本 和宏; 木村 展之
    基礎老化研究, 38(3), 43 - 49, Sep. 2014リポジトリ
  • 【アミロイドーシス:異常構造タンパク質の沈着・伝播機構と病態】脳アミロイドーシスの病態と伝播
    小野 賢二郎; 山田 正仁; 樋口 京一
    Dementia Japan, 28(3), 267 - 274, Sep. 2014
  • 【アミロイド関連神経疾患のすべて-封入体筋炎からアルツハイマー病まで】老人性全身性アミロイドーシス
    矢崎 正英; 樋口 京一
    BRAIN and NERVE: 神経研究の進歩, 66(7), 817 - 826, Jul. 2014
    https://search.jamas.or.jp/default/link?pub_year=2014&ichushi_jid=J04871&link_issn=&doc_id=20140718240011&doc_link_id=1390283684971034240&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390283684971034240&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_2.gifリポジトリ
  • 腸内フローラと加齢 老化促進モデルマウス(SAM)を用いた老化および抗老化研究
    樋口 京一; 田 耕; 澤下 仁子; 森 政之; 細川 昌則; 竹田 俊男
    腸内フローラシンポジウム, 22, 39 - 49, Jul. 2014
  • マウス老化アミロイド線維AApoAIIの細胞外沈着が誘発する小胞体ストレス応答
    羅 宏敏; 澤下 仁子; 田 耕; 劉 穎業; 李 琳; 丁 欣; 徐 哲; 楊 沐; 宮原 大貴; 森 政之; 銭 金澤; 王 耀勇; 樋口 京一
    代謝異常治療研究基金研究業績集, 41, 97 - 105, Jan. 2014
  • 【認知症原因タンパク質のPropagation】全身性アミロイドーシスは伝播するか?(チーター及びマウス)
    樋口 京一
    Dementia Japan, 27(1), 54 - 61, Jan. 2013
  • 還元型コエンザイムQ10の加齢疾患抑制メカニズムの解明 老化促進モデルマウスを用いた解析
    田 耕; 澤下 仁子; 久保 博司; 西尾 信哉; 橋本 繁成; 鈴木 伸嘉; 吉村 豪兼; 王 耀勇; 森 政之; 細江 和典; 北野 光昭; 竹田 俊男; 宇佐美 真一; 樋口 京一
    基礎老化研究, 36(2), 49 - 49, Jul. 2012, Not invited
  • 神経変性疾患は個体間伝播するか? アミロイドーシス・モデルからの推論
    吉田 邦広; 樋口 京一; 池田 修一
    BRAIN and NERVE: 神経研究の進歩, 64(6), 665 - 674, Jun. 2012
    https://search.jamas.or.jp/default/link?pub_year=2012&ichushi_jid=J04871&link_issn=&doc_id=20120608370009&doc_link_id=10.11477%2Fmf.1416101217&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1416101217&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gifリポジトリ
  • マウス老化アミロイドーシスにおける熱ストレス反応の役割 HSF1ノックアウトマウスを用いた解析
    銭 金澤; 弘瀬 雅教; 王 耀勇; 張 倍茹; 付 笑影; 澤下 仁子; 張 鵬尭; 友澤 寛; 森 政之; 中井 彰; 樋口 京一
    基礎老化研究, 34(3), 23 - 26, Sep. 2010
    https://search.jamas.or.jp/default/link?pub_year=2010&ichushi_jid=J01656&link_issn=&doc_id=20101007390005&doc_link_id=%2Fel3kisro%2F2010%2F003403%2F005%2F0023-0026%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fel3kisro%2F2010%2F003403%2F005%2F0023-0026%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gifリポジトリ
  • Amyloid fibrils formed by selective N-, C-terminal sequences of mouse apolipoprotein A-II
    J. Sawashita; F. Kametani; K. Hasegawa; M. Mori; H. Naiki; K. Higuchi
    AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 17, 101 - 101, Apr. 2010, Not invitedWebofScienceリポジトリ
  • Reply from M. Mori, K. Higuchi and H. Nose
    Masayuki Mori; Keiichi Higuchi; Hiroshi Nose
    Journal of Physiology, 588(6), 1025, Mar. 2010リポジトリ電子ジャーナル
  • 【血液内科医へのアミロイドーシスの理解】アミロイドーシスの伝播 チーターのアミロイドーシスを例に
    樋口 京一
    血液フロンティア, 19(9), 1397 - 1402, Aug. 2009
  • 【アミロイドーシスUPDATE】アミロイドーシス全般の課題 アミロイドーシスのモデル動物 病態の理解と治療法の開発をめざして
    樋口 京一; 前田 秀一郎
    医学のあゆみ, 229(5), 423 - 428, May 2009
    https://search.jamas.or.jp/default/link?pub_year=2009&ichushi_jid=J00060&link_issn=&doc_id=20090512160020&doc_link_id=%2Faa7ayuma%2F2009%2F022905%2F021%2F0423-0428%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Faa7ayuma%2F2009%2F022905%2F021%2F0423-0428%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gifリポジトリ
  • チーターのアミロイドーシス アミロイドーシスはプリオンのように伝播するか?
    樋口 京一
    信州医学雑誌, 56(6), 405 - 406, Dec. 2008
    https://search.jamas.or.jp/default/link?pub_year=2008&ichushi_jid=J00685&link_issn=&doc_id=20081217330005&doc_link_id=%2Fdg2shins%2F2008%2F005606%2F026%2F0405-0406%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg2shins%2F2008%2F005606%2F026%2F0405-0406%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gifリポジトリ
  • チーターのアミロイドーシスはプリオンのように伝播するか?
    樋口 京一; 張 はい茹; 宇根 有美; 亀谷 富由樹; 澤下 仁子; 森 政之
    Dementia Japan, 22(2), 207 - 214, Aug. 2008リポジトリ
  • マウス第13番染色体上骨量遺伝子座の解析
    中西 りか; 清水 基行; 森 政之; 秋山 治彦; 大槻 文悟; 奥平 修三; 橋本 麻衣子; 樋口 京一; 細川 昌則; 坪山 直生; 中村 孝志
    Osteoporosis Japan, 15(2), 193 - 195, Apr. 2007
    https://search.jamas.or.jp/default/link?pub_year=2007&ichushi_jid=J03021&link_issn=&doc_id=20070515120011&doc_link_id=%2Fai6ostoe%2F2007%2F001502%2F011%2F0193-0195%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fai6ostoe%2F2007%2F001502%2F011%2F0193-0195%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gifリポジトリ
  • 【アミロイドの謎は解けるか? プリオン病・アルツハイマー病・透析アミロイドーシスなどの病態を紐解く】アミロイドーシスの伝播
    樋口 京一
    細胞工学, 26(2), 177 - 180, Jan. 2007リポジトリ
  • 【アミロイドの謎は解けるか? プリオン病・アルツハイマー病・透析アミロイドーシスなどの病態を紐解く】アミロイドーシス発症の分子機構解明を目指して 現状と展望、夢
    後藤 祐児; 桑田 一夫; 関島 良樹; 田中 元雅; 内木 宏延; 永井 義隆; 松崎 勝巳; 樋口 京一
    細胞工学, 26(2), 181 - 185, Jan. 2007リポジトリ
  • 【細胞内タンパク質の社会学 合成・品質管理・輸送・分解のケアシステムと疾患発症機構】暴走するタンパク質 病態 制御不能タンパク質が引き起こす病態
    樋口 京一
    実験医学, 23(15), 2377 - 2383, Sep. 2005リポジトリ
  • 老化とアミロイドーシス
    樋口 京一; 付 笑影
    基礎老化研究, 28(4), 7 - 13, Oct. 2004リポジトリ
  • 【細胞における蛋白質の一生 生成・成熟・輸送・管理・分解・病態】病態・フォールディング病 アミロイドーシスの伝播機構
    樋口 京一
    蛋白質・核酸・酵素, 49(7), 1101 - 1104, May 2004
    https://search.jamas.or.jp/default/link?pub_year=2004&ichushi_jid=J00808&link_issn=&doc_id=20040510450010&doc_link_id=1522825130577297920&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1522825130577297920&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gifリポジトリ
  • 【老化とアフェレシス】アミロイドーシスと老化
    樋口 京一
    日本アフェレシス学会雑誌, 23(2), 143 - 150, May 2004
    https://search.jamas.or.jp/default/link?pub_year=2004&ichushi_jid=J02992&link_issn=&doc_id=20040521200003&doc_link_id=http%3A%2F%2Fid.nii.ac.jp%2F1141%2F00150420%2F&url=http%3A%2F%2Fid.nii.ac.jp%2F1141%2F00150420%2F&type=%E5%9B%BD%E7%AB%8B%E6%83%85%E5%A0%B1%E5%AD%A6%E7%A0%94%E7%A9%B6%E6%89%80%EF%BC%9ANii%E3%83%97%E3%83%AD%E3%82%B8%E3%82%A7%E3%82%AF%E3%83%88%E3%83%AA%E3%83%9D%E3%82%B8%E3%83%88%E3%83%AA&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F80182_3.gifリポジトリ
  • 【老化と疾病】基礎 老化疾患モデル マウス
    森 政之; 樋口 京一
    現代医療, 34(2), 349 - 354, Feb. 2002リポジトリ
  • マウスを用いた老化・寿命の分子遺伝学的研究
    森 政之; 樋口 京一
    基礎老化研究, 25(2), 77 - 82, Oct. 2001リポジトリ
  • 【老いの生物学と臨床医学】老いの生物学 SAMPマウスとリポ蛋白質
    樋口 京一; 梅澤 眞樹子
    Geriatric Medicine, 39(9), 1399 - 1404, Sep. 2001リポジトリ
  • 【コモンディジーズの遺伝子解析】老化促進マウス(SAM)の解析
    樋口 京一; 森 政之
    BIO Clinica, 16(9), 825 - 829, Aug. 2001
  • 老化促進モデルマウスSAMを用いた第11染色体骨量制御遺伝子座の解析
    清水 基行; 松下 陸; 笠井 宗一郎; 中村 孝志; 坪山 直生; 細川 昌則; 清水 慶彦; 樋口 京一
    Osteoporosis Japan, 9(2), 196 - 199, Apr. 2001リポジトリ
  • 【加齢と性差】Topics老化の機序,老化徴候に関連して 老化モデル動物の性差
    中村 明宏; 樋口 京一
    Geriatric Medicine, 38(12), 1833 - 1836, Dec. 2000リポジトリ
  • Ogg1遺伝子の突然変異はSAMP1系マウスの促進老化・短寿命の原因ではない
    森 政之; 豊國 伸哉; 十一 英子; 細川 昌則; 樋口 京一
    基礎老化研究, 24(1), 45 - 45, Jun. 2000
  • 老化促進モデルマウスSAMを用いた骨量制御遺伝子座の解析
    清水 基行; 坪山 直生; 松下 睦; 笠井 宗一郎; 清水 慶彦; 樋口 京一; 細川 昌則; 中村 孝志
    Osteoporosis Japan, 8(2), 248 - 250, Apr. 2000リポジトリ
  • Ogg1遺伝子の突然変異とSAMP系マウスの短寿命との関連
    森 政之; 豊國 伸哉; 近藤 昇平; 十一 英子; 細川 昌則; 樋口 京一
    日本病理学会会誌, 89(1), 284 - 284, Mar. 2000
  • 老化促進モデルマウス(SAM)
    樋口 京一
    信州医学雑誌, 48(1), 7 - 14, Feb. 2000
    https://search.jamas.or.jp/default/link?pub_year=2000&ichushi_jid=J00685&link_issn=&doc_id=20000218040002&doc_link_id=http%3A%2F%2Fhdl.handle.net%2F10091%2F9270&url=http%3A%2F%2Fhdl.handle.net%2F10091%2F9270&type=%E4%BF%A1%E5%B7%9E%E5%A4%A7%E5%AD%A6%EF%BC%9A%E4%BF%A1%E5%B7%9E%E5%A4%A7%E5%AD%A6%E6%A9%9F%E9%96%A2%E3%83%AA%E3%83%9D%E3%82%B8%E3%83%88%E3%83%AA&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F80022_3.gifリポジトリ
  • 【自然発症疾患モデル動物】老年性骨粗鬆症(老化促進)
    細川 昌則; 坪山 直生; 樋口 京一; 松下 睦; 中村 孝志
    Molecular Medicine, 別冊(自然発症疾患モデル動物), 46 - 49, Oct. 1999
  • 老化促進マウス
    樋口 京一
    BIO Clinica, 14(9), 830 - 834, Aug. 1999
  • Ogg1遺伝子の突然変異とSAMP系マウスの老化表型との関連
    森 政之; 内木 宏延; 中村 明宏; 千葉 卓哉; 近藤 昌平; 豊國 伸哉; 細川 昌則; 樋口 京一
    基礎老化研究, 23(1), 51 - 51, Jun. 1999
  • Ogg1遺伝子の突然変異とSAMP系マウスの老化表型との関連
    森 政之; 内木 宏延; 中村 明宏; 千葉 卓哉; 近藤 昌平; 豊國 伸哉; 細川 昌則; 樋口 京一
    日本病理学会会誌, 88(1), 331 - 331, Mar. 1999
  • アミロイド蛋白質の線維形成機構
    樋口 京一
    基礎老化研究, 22(1), 10 - 12, Jun. 1998
  • 【遺伝子から探る老化のメカニズム】老化と寿命の分子遺伝学 老化促進モデルマウス(SAM)を用いた老化科学への分子的アプローチ
    樋口 京一; 細川 昌則
    Molecular Medicine, 35(5), 608 - 615, Apr. 1998リポジトリ
  • 自然発症疾患モデル動物 病因病態解析・遺伝子治療へのアプローチ 老年性骨粗鬆症(老化促進モデルマウス:SAMP6)
    細川 昌則; 坪山 直生; 樋口 京一
    Molecular Medicine, 35(4), 541 - 544, Mar. 1998リポジトリ
  • 【エイジングの分子細胞生物学】老化モデル 老化モデルとしてのSenescence-Accelerated Mouse(SAM)
    細川 昌則; 樋口 京一
    現代医療, 30(2), 483 - 488, Feb. 1998
  • 【老化研究の最前線】老化促進モデルマウスの病態病理
    細川 昌則; 樋口 京一
    BIO Clinica, 13(2), 121 - 124, Feb. 1998
  • 老化促進モデルマウス(SAM)の寿命・老化病態を制御する遺伝子の探索
    樋口 京一
    基礎老化研究, 21(1), 12 - 15, Oct. 1997
  • 老化の基礎 老化モデル
    樋口 京一; 細川 昌則; 竹田 俊男
    老年消化器病, 8(2), 171 - 175, Nov. 1996リポジトリ
  • 老化促進モデルマウス(SAMP10)に認められる脳内神経成長因子の加齢変化 免疫組織学的検討
    大西 克則; 樋口 京一; 細川 昌則
    代謝異常治療研究基金研究業績集, 22, 143 - 148, Nov. 1995
  • 腹部疾患の画像診断 下部消化管のCT・MRI診断
    今井 裕; 樋口 順也; 平松 京一
    最新医学, 50(10), 2021 - 2025, Oct. 1995リポジトリ
  • 高解像力MRIと表面(局所)コイル 表面コイルの臨床応用について
    今井 裕; 樋口 順也; 平松 京一
    日独医報, 39(4), 609 - 617, Mar. 1995リポジトリ
  • 老化と遺伝のからみ
    樋口 京一
    日本体質学雑誌, 57(2), 11 - 12, Jun. 1994
  • 老化と遺伝 老化モデル動物と遺伝
    樋口 京一
    老化と疾患, 6(12), 1743 - 1750, Dec. 1993
  • 老化アミロイドーシス沈着機構の分子病理学的解析
    樋口 京一
    最新医学, 48(12), 2296 - 2301, Dec. 1993リポジトリ
  • 〔アミロイドーシス〕老化とアミロイドーシス
    樋口 京一; 竹田 俊男
    内科MOOK, (35), 251 - 259, Aug. 1987
  • 老化促進モデルマウス(SAM)における血清中apo SASSAM,apo A-1,LDL濃度の加齢変化
    竹田 俊男; 樋口 京一; 松村 敦子
    代謝異常治療研究基金研究業績集, 13, 115 - 122, Jan. 1986
  • 老化促進モデルマウス(SAM)における結合組織の加齢変化
    樋口 京一; 樋口 佳代子; 松下 睦
    結合組織, 17(2), 110 - 113, Aug. 1985リポジトリ
  • Senescence Accelerated Mouse老化促進モデルマウスの開発
    竹田 俊男; 樋口 京一; 松村 敦子
    感染・炎症・免疫, 14(6), 434 - 440, Dec. 1984
  • 骨・腱コラーゲン,ピリジノリン架橋のinvitroagingについて
    清水克時; 山室隆夫; 樋口京一
    日本外科宝函, 50(6), 789 - 795, Nov. 1981
    https://search.jamas.or.jp/default/link?pub_year=1981&ichushi_jid=J01067&link_issn=&doc_id=19824070817060&doc_link_id=http%3A%2F%2Fhdl.handle.net%2F2433%2F208569&url=http%3A%2F%2Fhdl.handle.net%2F2433%2F208569&type=%E4%BA%AC%E9%83%BD%E5%A4%A7%E5%AD%A6%EF%BC%9A%E4%BA%AC%E9%83%BD%E5%A4%A7%E5%AD%A6%E5%AD%A6%E8%A1%93%E6%83%85%E5%A0%B1%E3%83%AA%E3%83%9D%E3%82%B8%E3%83%88%E3%83%AA&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F80028_3.gifリポジトリ

Books and other publications

  • SAM(老化促進モデルマウス)『モデル動物の作成と維持』
    樋口京一、森　政之。, Single work
    エル・アイ・シー（東京）, 2004
  • 分子生物学・免疫学キーワード辞典（第2版）
    樋口京一、森　政之, Joint work
    医学書院, 2003
  • 「分子シャペロンによる細胞機能制御」；アミロイド線維タンパク質、シュプリンガー・フェアラーク東京、単著、永田和宏・森正敬・吉田賢右編、pp164-174, 総頁数219頁中11頁を担当.
    Single work
    2001
  • 「Les Amyloidoses」: Model of Amyloidosis of Senescence, Flammarion Medicine Science , 共著、G. Grateuau ,MD. Benson　他2名編集、K. Higuchi, H. Naiki, M. Hosokawa, T. Takada . pp138-145, 総頁数585頁中8頁を担当.
    Single work
    2000

Lectures, oral presentations, etc.

  • Deposition if Age-related ApolipoproteinA-II and Medin Amyloidosis in Aged C57BL/6J Mice
    Keiichi Higuchi; Ying Li; Jian Dai; Fuyuki Kametani; Masahide Yazaki; Masayuki Mori; Hiroki Miyahara
    第113回日本病理学会総会, Mar. 2024, Not invited, リポジトリ
  • 老化に伴うタンパク質恒常性の破綻：アミロイドーシス
    樋口京一; 宮原大貴
    第96回日本生化学大会 シンポジウム 老化を制御するプロテオスタシスとその変容, Nov. 2023, Not invited, リポジトリ
  • C57BL/6Jマウスにおける加齢に伴うMedin沈着病態の検討
    宮原大貴; 李螢, 代健; 判田勇介; 田川響; 大椛涼帆; 亀谷富由樹; 森政之; 樋口京一; 矢﨑正英
    第10回日本アミロイドーシス学会学術集会, Sep. 2023, Not invited, リポジトリ
  • Molecular Mechanisms of;Exercise Training Effects.
    Keiichi Higuchi
    日本生理学会第100回記念大会 シンポジウム 生理学から"運動医学"への挑戦：科学的エビデンスと社会実装, Mar. 2023, Invited

Research Themes

  • 高齢者の運動トレーニングによる体力向上と認知機能改善：大規模検証システムの開発
    科学研究費助成事業, 日本学術振興会, 基盤研究(B)
    信州大学
    01 Apr. 2023 - 31 Mar. 2026
  • マウスとヒトを用いたインターバル運動の健康増進機序の解明と効果評価法の開発
    科学研究費助成事業 基盤研究(C), 日本学術振興会, 基盤研究(C)
    信州大学
    01 Apr. 2023 - 31 Mar. 2026
  • XEpigenetic mechanisms for age-associated decline in physiological function
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
    Shinshu University
    01 Apr. 2018 - 31 Mar. 2021
  • Validation of life extension effect of reduced form Coenzyme Q10
    Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Research (Exploratory)
    Shinshu University
    30 Jun. 2017 - 31 Mar. 2021
  • Integrative pathology of Amyloidosis: Exploratory research on the basis of transmission phenomena
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
    Shinshu University
    01 Apr. 2017 - 31 Mar. 2020
  • Molecular pathogenesis of amyloidosis: Integration of protein chemistry, mouse models and clinical pathology
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
    University of Fukui
    01 Apr. 2016 - 31 Mar. 2020
  • The preventive effects of exercise + milk product intake on lifestyle-related diseases and heat illness: the establishment of remote research system on a large population of subjects
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A)
    Shinshu University
    01 Apr. 2015 - 31 Mar. 2018
  • Analysis of Amyloid Related Proteins with Advanced Laser Microdissection
    Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research
    Shinshu University
    01 Apr. 2014 - 31 Mar. 2018
  • Development of preventive and therapeutic treatments based on the pathogenesis of the transmission of amyloidosis
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
    Shinshu University
    01 Apr. 2014 - 31 Mar. 2017
  • Molecular design of novel phenylpropanoid-derived anti-amyloidal compounds using quantum-dot probes
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
    Shinshu University
    01 Apr. 2014 - 31 Mar. 2017
  • Development and application of a reporter bioassay system to screen for phytochemicals mimicking the anti-aging effects of caloric restriction
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
    Waseda University
    01 Apr. 2013 - 31 Mar. 2016
  • Molecular pathological environments promoting/inhibiting the development of amyloidosis: the synergistic interaction of protein science and animal models
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
    University of Fukui
    01 Apr. 2013 - 31 Mar. 2016
  • Changes in expression of L-type calcium channel subunits in skeletal muscle with aging.
    Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research
    Shinshu University
    01 Apr. 2013 - 31 Mar. 2016
  • Preventive effects and molecular mechanisms for metabolic abnormalities by a short-term intervention of caloric restriction and exercise
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
    Shinshu University
    01 Apr. 2012 - 31 Mar. 2016
  • The mechanisms for deterioration of thermoregulatory responses in older people and the counter measure against their heat illness
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A)
    Shinshu University
    01 Apr. 2012 - 31 Mar. 2015
  • Pathological Investigation of the Pathogenesis and Development of Preventive and Therapeutic Procedures for Amyloidosis
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
    Shinshu University
    01 Apr. 2011 - 31 Mar. 2014
  • Molecular modeling of anti-amyloidal catechol derivatives using amyloidogenic proteins
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
    Shinshu University
    2011 - 2013
  • Comprehensive Proteome Analysis of Age-related Changes in Amyloid Like Aggregates
    Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research
    Shinshu University
    2011 - 2013
  • Clarification of the molecular pathogenesis of human amyloidosis by in vitro amyloid fibril formation systems and transgenic mouse model
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
    University of Fukui
    2010 - 2012
  • アミロイド線維の伝播によるタンパク質社会の秩序破綻と回復機構の解析
    科学研究費助成事業 特定領域研究, 日本学術振興会, 特定領域研究
    信州大学
    2010 - 2011
  • Health promotional effects of the combination of supplementation and exercise in old mice having various genetic backgrounds
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
    Shinshu University
    2009 - 2011
  • Systemic analysis of amyloidosis using animal models
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
    Shinshu University
    2008 - 2010
  • Use of genetically altered mice to develop new preventives against familial amyloidoses.
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
    University of Yamanashi
    2006 - 2008
  • Molecular pathogenesis of dialysis-related amyloidosis-A fusion of the in vitro model and the animal model-
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
    University of Fukui
    2006 - 2008
  • Molecular-genetic analysis of age related hearing impairment
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
    Shinshu University
    2005 - 2008
  • a-adrenergic receptor responsiveness and baroreflex control of muscle blood flow:human and animal studies
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A)
    Shinshu University
    2005 - 2007
  • Investigation into the pathogenesis of amyloidosis using the newly developed animal models.
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
    Shinshu University
    2005 - 2007
  • アミロイドーシス伝播機構解明と感染物質検出システムの開発
    科学研究費助成事業 特別研究員奨励費, 日本学術振興会, 特別研究員奨励費
    信州大学
    2005 - 2006
  • 病的構造タンパク質(アミロイド線維)の伝播及び形成機構の解析
    科学研究費助成事業 特定領域研究, 日本学術振興会, 特定領域研究
    信州大学
    2005 - 2006
  • 熟年体育大学を基盤とした運動効率関連遺伝子の探策
    科学研究費助成事業 萌芽研究, 日本学術振興会, 萌芽研究
    信州大学
    2005 - 2006
  • 骨粗鬆症モデルマウス(SAMP6)を用いた骨量決定遺伝子群の同定
    科学研究費助成事業 特定領域研究, 日本学術振興会, 特定領域研究
    信州大学
    2004 - 2004
  • Elucidation of the molecular pathogenesis of dialysis-related amyloidosis.
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
    2003 - 2005
  • 病的構造タンパク質(アミロイド線維)の伝播及び形成機構の解析
    科学研究費助成事業 特定領域研究, 日本学術振興会, 特定領域研究
    信州大学
    2003 - 2004
  • RESEARCH ON THE MOLECULAR MECHANISM UNDERLYING THE TRANSMISSION PHENOMENON IN AMYLOIDOSES INVOLVING HUMAN NEUROLOGICAL SYSTEMS
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
    SHINSHU UNIVERSITY
    2003 - 2004
  • 骨粗鬆症モデルマウス(SAMP6)を用いた骨量決定遺伝子群の同定
    科学研究費助成事業 特定領域研究, 日本学術振興会, 特定領域研究
    信州大学
    2003 - 2003
  • アミロイド線維による伝播/感染機構と宿主応答の解析
    科学研究費助成事業 特定領域研究, 日本学術振興会, 特定領域研究
    信州大学
    2003 - 2003
  • Molecular Genetic Analysis of Senescence-Accelerated Mouse (SAM)
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
    Shinshu University
    2002 - 2004
  • Analysis and application of newly discovered rat L1 retotransposon
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
    Shinshu University
    2002 - 2003
  • 新たに発見された活性型L1レトロトランスポゾンの実験病理学への応用
    科学研究費助成事業 萌芽研究, 日本学術振興会, 萌芽研究
    信州大学
    2002 - 2003
  • 骨粗鬆症モデルマウス(SAMP6)を用いた骨量決定遺伝子群の同定
    科学研究費助成事業 特定領域研究, 日本学術振興会, 特定領域研究
    信州大学
    2002 - 2002
  • アミロイドタンパク質の病的構造伝播機構の解析
    科学研究費助成事業 特定領域研究, 日本学術振興会, 特定領域研究
    信州大学
    2002 - 2002
  • A new exercise training program for the elderly by developing a novel handy calorie meter and an IT network system after the determination of human genome sequences.
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
    Shinshu University
    2001 - 2003
  • 自然突然変異型OGG1を持つマウス群を用いたDNA酸化傷害と発がんとの関連の解明
    科学研究費助成事業 特定領域研究(C), 日本学術振興会, 特定領域研究(C)
    信州大学
    2000 - 2000
  • Effects of restricted food intake and spontaneous wheel running on aging and longevity in senescence-accelerated mouse ( SAM )
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
    Shinshu University School of Medicine
    1999 - 2001
  • Analysis of the mechanism of misfolding to amyloid protein using mouse amyloidosis
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)., Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B).
    Shinshu University
    1999 - 2000
  • Analysis of repair systems for oxidative DNA damage in Senescence-Accelerated Mouso
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
    Shinshu University
    1999 - 2000
  • マウス個体老化の分子的把握:老化臓器の遺伝子発現レパートリィの作成
    科学研究費助成事業 萌芽的研究, 日本学術振興会, 萌芽的研究
    信州大学
    1999 - 2000
  • アミロイド蛋白(apoA-II)の線維構造への変換を制御する分子シャペロン
    科学研究費助成事業 特定領域研究(A), 日本学術振興会, 特定領域研究(A)
    信州大学
    1998 - 1998
  • Roles of molecular chaperones in cell function
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Priority Areas (A), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research on Priority Areas (A)
    Kyoto University
    1997 - 2001
  • Studies of the Pathogenesis of Amyloidosis : Verification of the Hypothesis 'Transmission of Abnormal Proteins Structure' Using Mouse Senile Amyloidosis.
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
    1997 - 1998
  • Molecular and Cellular Basis of Senescence Acceleration
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
    KYOTO UNIVERSITY
    1997 - 1998
  • マウスアミロイド蛋白(apoA-II)の構造交換と分子シャペロン
    科学研究費助成事業 重点領域研究, 日本学術振興会, 重点領域研究
    京都大学
    1997 - 1997
  • Effect protein deficiency on lnsulin like growth factor-I and lnsulin like growth factor-II gene expression physiological reles of lnsulin like growth factors as a local factore in growing lambs-
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
    KYOTO UNIVERSITY
    1996 - 1997
  • Relationship between age-related immune dysfunction and senile amyloidosis in shortened life length in SAM mice
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
    1996 - 1997
  • Development of the Gene Therapeutic Treatment to Mouse Senile Amyloidosis
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
    KYOTO UNIVERSITY
    1995 - 1996
  • Comprehensive studies on age-related deficits in learning and memory in SAM
    Grants-in-Aid for Scientific Research Grant-in-Aid for General Scientific Research (A), Japan Society for the Promotion of Science, Grant-in-Aid for General Scientific Research (A)
    Kyoto University
    1991 - 1993
  • Molecular genetic analysis of muirne senile amyloidosis.
    Grants-in-Aid for Scientific Research Grant-in-Aid for General Scientific Research (C), Japan Society for the Promotion of Science, Grant-in-Aid for General Scientific Research (C)
    KYOTO UNIVERSITY
    1991 - 1992
  • Development of murine models for aging brain, Senescence-Accelerated Mouse (SAM)
    Grants-in-Aid for Scientific Research Grant-in-Aid for Developmental Scientific Research (A), Japan Society for the Promotion of Science, Grant-in-Aid for Developmental Scientific Research (A)
    KYOTO UNIVERSITY
    1990 - 1992
  • ApoB mRNAに出現するゲノDNAにコ-ドサれないストップコドンに関する研究
    科学研究費助成事業 重点領域研究, 日本学術振興会, 重点領域研究
    京都大学
    1990 - 1990
  • Modulatory Effect of Dietary Restriction on the Advance of Senescence in Senescence Accelerated Mouse (SAM)
    Grants-in-Aid for Scientific Research Grant-in-Aid for General Scientific Research (B), Japan Society for the Promotion of Science, Grant-in-Aid for General Scientific Research (B)
    KYOTO UNIVERSITY
    1989 - 1990
  • Molecular Genetic Study of Mouse Senile Amyloidosis
    Grants-in-Aid for Scientific Research Grant-in-Aid for General Scientific Research (C), Japan Society for the Promotion of Science, Grant-in-Aid for General Scientific Research (C)
    Kuoto University
    1989 - 1990
  • ApoBmRNAに出現するゲノムDNAにコ-ドされないストップコドンに関する研究
    科学研究費助成事業 重点領域研究, 日本学術振興会, 重点領域研究
    京都大学
    1989 - 1989
  • A New Strain of Mice with Late-appearing Cataract, It's development from Senescence Accelerated Mouse (SAM) and characters of cataract.
    Grants-in-Aid for Scientific Research Grant-in-Aid for General Scientific Research (C), Japan Society for the Promotion of Science, Grant-in-Aid for General Scientific Research (C)
    Kyoto University
    1987 - 1988
  • Experimental studies on the pathogenesis and modulation of age-related pathologies in Senescence Acelerated Mouse (SAM).
    Grants-in-Aid for Scientific Research Grant-in-Aid for General Scientific Research (A), Japan Society for the Promotion of Science, Grant-in-Aid for General Scientific Research (A)
    Kyoto University
    1986 - 1988
  • リポタンパク質特にHDLの代謝調整の基礎的研究
  • アミロイド－シス発祥機構の分子生物学的研究
  • マウス特に老化促進モデルマウス（SAM)を用いた老化、寿命、老化病態の遺伝的要因の解析