医学博士, 信州大学

Medical biochemistry

Orthopedics

Orthopedics Immunology

2022 - Present
信州大学医学部附属病院, 整形外科

2019 - 2022
Columbia University, Columbia Stem Cell Initiative, Postdoctoral Research Scientist

2015 - 2019
信州大学医学部附属病院

2014 - 2015
飯田市立病院, 整形外科

2013 - 2014
信州上田医療センター, 整形外科

2012 - 2013
篠ノ井総合病院

2015 - 2019, Shinshu University, Graduate School of Medicine

2003 - 2009, Shinshu University, School of Medicine, 医学科

2021
Japanese Medical Society of America, Raymond Sekiguchi MD-JMSA Scholarship
International academic award

2021
Raymond Sekiguchi MD – JMSA Scholarship

2020
信州大学運動機能学教室同門会, 同門会賞
Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T cell activation markers, International academic award

2020
信州大学運動機能学教室同門会賞

Postoperative patient-reported outcome measures after medial open-wedge high tibial osteotomy was improved by decreased joint line convergence angle.
Daiki Kumaki; Keiji Tensho; Tomoya Iwaasa; Yusuke Maezumi; Kazushige Yoshida; Suguru Koyama; Hiroki Shimodaira; Hiroshi Hiriuchi; Jun Takahashi
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 32(8), 2129-2140, Aug. 2024, Refereed
Lead

An Insertion Device for Effective Delivery of Fibrin Clot to the Meniscus Tear
Kazushige Yoshida; Keiji Tensho; Yusuke Maezumi; Daiki Kumaki; Hiroki Shimodaira; Hiroshi Horiuchi; Jun Takahashi
Arthroscopy Techniques, 103042-103042, May 2024, Refereed
Lead

Developing inhibitory peptides against SARS-CoV-2 envelope protein
Ramsey Bekdash; Kazushige Yoshida; Manoj S. Nair; Lauren Qiu; Johnathan Ahdout; Hsiang-Yi Tsai; Kunihiro Uryu; Rajesh K. Soni; Yaoxing Huang; David D. Ho; Masayuki Yazawa
PLOS Biology, 22(3), e3002522-e3002522, Mar. 2024, Refereed
Lead

Does posterior tibial slope laterality exist? A matched cohort study between ACL-injured and non-injured knees.
Keiji Tensho; Daiki Kumaki; Kazushige Yoshida; Hiroki Shimodaira; Hiroshi Horiuchi; Jun Takahashi
Journal of experimental orthopaedics, 10(1), 132-132, Dec. 2023, Refereed
Lead

Posterior Opening-Wedge Osteotomy for Posterior Tibial Slope Correction of Failed Anterior Cruciate Ligament Reconstruction.
Keiji Tensho; Daiki Kumaki; Kazushige Yoshida; Hiroki Shimodaira; Hiroshi Horiuchi; Jun Takahashi
Arthroscopy techniques, 12(12), e2303-e2311, Dec. 2023, Refereed
Lead

Effect of a new remnant-preserving technique with anatomical double-bundle anterior cruciate ligament reconstruction on MRI-based graft maturity: a comparison cohort study.
Hiroki Shimodaira; Keiji Tensho; Suguru Koyama; Tomoya Iwaasa; Daiki Kumaki; Kazushige Yoshida; Hiroshi Horiuchi; Jun Takahashi
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 31(6), 2394-2405, Jun. 2023, Refereed
Lead

Macroscopic and microscopic findings of multi-folded hamstring grafts of anatomical double-bundle ACL reconstruction 13 years after surgery.
Daiki Kumaki; Keiji Tensho; Mai Iwaya; Tomoya Iwaasa; Kazushige Yoshida; Suguru Koyama; Hiroki Shimodaira; Hiroshi Horiuchi; Jun Takahashi
Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 31(6), 2406-2411, Jun. 2023, Refereed
Lead

Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome.
LouJin Song; Ramsey Bekdash; Kumi Morikawa; Jose R Quejada; Alison D Klein; Danielle Aina-Badejo; Kazushige Yoshida; Hannah E Yamamoto; Amy Chalan; Risako Yang; Achchhe Patel; Dario Sirabella; Teresa M Lee; Leroy C Joseph; Fuun Kawano; Junco S Warren; Rajesh K Soni; John P Morrow; Masayuki Yazawa
Nature cardiovascular research, 1(2), 142-156, Feb. 2022, Refereed
Lead

Antitumor Effect of Sclerostin against Osteosarcoma.
Hirokazu Ideta; Kazushige Yoshida; Masanori Okamoto; Jun Sasaki; Munehisa Kito; Kaoru Aoki; Yasuo Yoshimura; Shuichiro Suzuki; Atsushi Tanaka; Akira Takazawa; Hisao Haniu; Takeshi Uemura; Takashi Takizawa; Atsushi Sobajima; Takayuki Kamanaka; Jun Takahashi; Hiroyuki Kato; Naoto Saito
Cancers, 13(23), Nov. 2021
Lead

Isolated lymphatic vessel lumen perfusion system for assessing nanomaterial movements and nanomaterial-induced responses in lymphatic vessels
Chika Kuroda; Kumiko Ajima; Katsuya Ueda; Atsushi Sobajima; Kazushige Yoshida; Takayuki Kamanaka; Jun Sasaki; Haruka Ishida; Hisao Haniu; Masanori Okamoto; Kaoru Aoki; Hiroyuki Kato; Naoto Saito
NANO TODAY, 36, Feb. 2021, Refereed
Lead

Carbon fibers for treatment of cancer metastasis in bone.
Takayuki Kamanaka; Hisao Haniu; Manabu Tanaka; Takashi Takizawa; Kaoru Aoki; Masanori Okamoto; Atsushi Sobajima; Kazushige Yoshida; Hirokazu Ideta; Tetsuhiko Mimura; Haruka Ishida; Katsuya Ueda; Takeshi Uemura; Jin Hee Kim; Yoong Ahm Kim; Hiroyuki Kato; Naoto Saito
RSC advances, 10(55), 33071-33079, Sep. 2020, Refereed
Lead

A Review of T-Cell Related Therapy for Osteosarcoma.
Kazushige Yoshida; Masanori Okamoto; Kaoru Aoki; Jun Takahashi; Naoto Saito
International journal of molecular sciences, 21(14), Jul. 2020, Refereed, Invited
Lead

Applications of Carbon Nanotubes in Bone Regenerative Medicine.
Manabu Tanaka; Kaoru Aoki; Hisao Haniu; Takayuki Kamanaka; Takashi Takizawa; Atsushi Sobajima; Kazushige Yoshida; Masanori Okamoto; Hiroyuki Kato; Naoto Saito
Nanomaterials (Basel, Switzerland), 10(4), Apr. 2020, Refereed
Lead

Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells.
Kazushige Yoshida; Masanori Okamoto; Jun Sasaki; Chika Kuroda; Haruka Ishida; Katsuya Ueda; Hirokazu Ideta; Takayuki Kamanaka; Atsushi Sobajima; Takashi Takizawa; Manabu Tanaka; Kaoru Aoki; Takeshi Uemura; Hiroyuki Kato; Hisao Haniu; Naoto Saito
BMC cancer, 20(1), 25-25, Jan. 2020
Lead

The interrelationship between anterior cruciate ligament tibial footprint and anterolateral meniscal root insertions: Quantitative, morphological and positional analyses using three-dimensional computed tomography images.
Keiji Tensho; Tomoya Iwaasa; Suguru Koyama; Kazushige Yoshida; Hiroki Shimodaira; Hiroshi Horiuchi; Hiroyuki Kato; Naoto Saito; Nanae Fukushima
The Knee, 26(5), 969-977, Oct. 2019, Refereed
Lead

Using the Barthel Index to Assess Activities of Daily Living after Musculoskeletal Tumour Surgery: A Single-centre Observational Study.
Masanori Okamoto; Munehisa Kito; Yasuo Yoshimura; Kaoru Aoki; Shuichiro Suzuki; Atsushi Tanaka; Akira Takazawa; Kazushige Yoshida; Yoshikazu Ido; Takaaki Ishida; Keiko Kawasaki; Hiroyuki Kato
Progress in rehabilitation medicine, 4, 20190010-20190010, 2019
Lead

Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T cell activation markers.
Kazushige Yoshida; Masanori Okamoto; Jun Sasaki; Chika Kuroda; Haruka Ishida; Katsuya Ueda; Satomi Okano; Hirokazu Ideta; Takayuki Kamanaka; Atsushi Sobajima; Takashi Takizawa; Munehisa Kito; Kaoru Aoki; Takeshi Uemura; Hisao Haniu; Hiroyuki Kato; Naoto Saito
OncoTargets and therapy, 12, 2513-2518, 2019
Lead

Organ accumulation and carcinogenicity of highly dispersed multi-walled carbon nanotubes administered intravenously in transgenic rasH2 mice.
Atsushi Sobajima; Hisao Haniu; Hiroki Nomura; Manabu Tanaka; Takashi Takizawa; Takayuki Kamanaka; Kaoru Aoki; Masanori Okamoto; Kazushige Yoshida; Jun Sasaki; Kumiko Ajima; Chika Kuroda; Haruka Ishida; Satomi Okano; Katsuya Ueda; Hiroyuki Kato; Naoto Saito
International journal of nanomedicine, 14, 6465-6480, 2019, Refereed
Lead

The status quo of treatment and clinical outcomes for patients over 80 years of age with high-grade soft tissue sarcoma: report from the soft tissue tumor registry in Japan.
Masanori Okamoto; Munehisa Kito; Yasuo Yoshimura; Kaoru Aoki; Shuichiro Suzuki; Atsushi Tanaka; Akira Takazawa; Kazushige Yoshida; Hiroyuki Kato
Japanese journal of clinical oncology, 48(10), 900-905, Oct. 2018, Refereed
Lead

骨肉腫に対する古典的Wntシグナル阻害因子スクレロスチンの抗腫瘍効果
岡本 正則; 吉田 和薫; 佐々木 純; 青木 薫; 高沢 彰; 鈴木 周一郎; 吉村 康夫; 鬼頭 宗久; 羽二生 久夫; 傍島 淳; 鎌仲 貴之; 根本 和明; 齋藤 直人; 加藤 博之
日本整形外科学会雑誌, 92(6), S1459-S1459, Jun. 2018, Refereed
Lead

Titanium Fiber Plates for Bone Tissue Repair.
Takashi Takizawa; Noboru Nakayama; Hisao Haniu; Kaoru Aoki; Masanori Okamoto; Hiroki Nomura; Manabu Tanaka; Atsushi Sobajima; Kazushige Yoshida; Takayuki Kamanaka; Kumiko Ajima; Ayumu Oishi; Chika Kuroda; Haruka Ishida; Satomi Okano; Shinsuke Kobayashi; Hiroyuki Kato; Naoto Saito
Advanced materials (Deerfield Beach, Fla.), 30(4), Jan. 2018
Lead

Different aggregation and shape characteristics of carbon materials affect biological responses in RAW264 cells.
Chika Kuroda; Katsuya Ueda; Hisao Haniu; Haruka Ishida; Satomi Okano; Takashi Takizawa; Atsushi Sobajima; Takayuki Kamanaka; Kazushige Yoshida; Masanori Okamoto; Tamotsu Tsukahara; Yoshikazu Matsuda; Kaoru Aoki; Hiroyuki Kato; Naoto Saito
International journal of nanomedicine, 13, 6079-6088, 2018
Lead

三次元配向連通孔ハイドロキシアパタイト製骨再生用スキャフォルドの物理化学・生体外・生体内的評価
田中 学; 鎌仲 貴之; 傍島 淳; 吉田 和薫; 青木 薫; 岡本 正則; 佐々木 純; 岩浅 智哉; 三村 哲彦; 羽二生 久夫; 齋藤 直人; 加藤 博之
日本整形外科学会雑誌, 91(8), S1537-S1537, Aug. 2017
Lead

In Vitro and In Vivo Evaluation of a Three-Dimensional Porous Multi-Walled Carbon Nanotube Scaffold for Bone Regeneration.
Manabu Tanaka; Yoshinori Sato; Mei Zhang; Hisao Haniu; Masanori Okamoto; Kaoru Aoki; Takashi Takizawa; Kazushige Yoshida; Atsushi Sobajima; Takayuki Kamanaka; Hiroyuki Kato; Naoto Saito
Nanomaterials (Basel, Switzerland), 7(2), Feb. 2017
Lead

Physico-Chemical, In Vitro, and In Vivo Evaluation of a 3D Unidirectional Porous Hydroxyapatite Scaffold for Bone Regeneration.
Manabu Tanaka; Hisao Haniu; Takayuki Kamanaka; Takashi Takizawa; Atsushi Sobajima; Kazushige Yoshida; Kaoru Aoki; Masanori Okamoto; Hiroyuki Kato; Naoto Saito
Materials (Basel, Switzerland), 10(1), Jan. 2017
Lead

非古典経路のWNT5Aは骨肉腫においてLRP5/6の発現を調節する
岡本 正則; 吉田 和薫; 青木 薫; 鬼頭 宗久; 田中 厚誌; 鈴木 周一郎; 高沢 彰; 福澤 拓馬; 薄井 雄企; 羽二生 久夫; 小林 伸輔; 田中 学; 吉村 康夫; 小林 泰浩; 加藤 博之; 齋藤 直人
日本整形外科学会雑誌, 90(8), S1799-S1799, Aug. 2016
Lead

Avulsion Fracture of the Calcaneus Treated With a Soft Anchor Bridge and Lag Screw Technique: A Report of Two Cases.
Kazushige Yoshida; Kentaro Kasama; Tsutomu Akahane
The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons, 55(2), 310-3, 2016
Lead

Giant cell tumor of the tendon sheath extending around the patellar tendon and invading the knee joint and tibia: A case report.
Tsutomu Akahane; Naoya Mori; Kazushige Yoshida
Oncology letters, 8(6), 2800-2802, Dec. 2014
Lead

ヒト骨芽細胞の網羅的抗体ライブラリ作製と発現タンパクに基づく細胞分化の解明
科学研究費助成事業, 日本学術振興会, 研究活動スタート支援
信州大学
31 Aug. 2022 - 31 Mar. 2024

Investigation of relationship between osteosarcoma and immune cells
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Early-Career Scientists
Shinshu University
01 Apr. 2018 - 31 Mar. 2020

Verification of the usefulness of anti-PD-1 antibody against osteosarcoma and clarification of relevance to Wnt signal
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B)
Shinshu University
01 Apr. 2016 - 31 Mar. 2018

Titanium fiber paper for compound fracture repair, bone tissue regeneration and enthesis reattachment.
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research
Shinshu University
01 Apr. 2015 - 31 Mar. 2018