2012 - 2017, National Heart, Lung and Blood Institute/NIH

2022
第96回日本薬理学会年会, Young Investigator Award
International academic award

2022
第146回日本薬理学会関東部会, 優秀発表賞
International academic award

2021
第50回日本心脈管作動物質学会, 研究奨励賞 最優秀賞
International academic award

2020
第30回日本循環薬理学会, Young Investigator Award
International academic award

2008
National Center for Geriatrics and Gerontology, Young Investigator Award
International academic award
Hiroyuki KAWAGISHI

Regeneration of Nonhuman Primate Hearts With Human Induced Pluripotent Stem Cell-Derived Cardiac Spheroids.
Hideki Kobayashi; Shugo Tohyama; Hajime Ichimura; Noburo Ohashi; Shuji Chino; Yusuke Soma; Hidenori Tani; Yuki Tanaka; Xiao Yang; Naoko Shiba; Shin Kadota; Kotaro Haga; Taijun Moriwaki; Yuika Morita-Umei; Tomohiko C Umei; Otoya Sekine; Yoshikazu Kishino; Hideaki Kanazawa; Hiroyuki Kawagishi; Mitsuhiko Yamada; Kazumasa Narita; Takafumi Naito; Tatsuichiro Seto; Koichiro Kuwahara; Yuji Shiba; Keiichi Fukuda
Circulation, Apr. 2024, Refereed
Lead

Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart
Kawagishi, Hiroyuki; Nakada, Tsutomu; Numaga-Tomita, Takuro; Larranaga, Maite; Guo, Ang; Song, Long-Sheng; Yamada, Mitsuhiko;
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 323(1), H103-H120, Jul. 2022

Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart
Hiroyuki Kawagishi; Tsutomu Nakada; Takuro Numaga-Tomita; Maite Larrañaga; Ang Guo; Long-Sheng Song; Mitsuhiko Yamada
American Journal of Physiology-Heart and Circulatory Physiology, May 2022, Refereed, Not invited
Lead, Corresponding

Adrenomedullin-RAMP2 and -RAMP3 Systems Regulate Cardiac Homeostasis during Cardiovascular Stress
Nanqi Cui; Takayuki Sakurai; Akiko Kamiyoshi; Yuka Ichikawa-Shindo; Hisaka Kawate; Megumu Tanaka; Masaaki Tanaka; Yangxuan Wei; Shinji Kakihara; Yunlu Zhao; Kohsuke Aruga; Hiroyuki Kawagishi; Tsutomu Nakada; Mitsuhiko Yamada; Takayuki Shindo
Endocrinology, 162(3), Mar. 2021, Refereed
Lead

Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses.
Ryan Houston; Shiori Sekine; Michael J Calderon; Fayaz Seifuddin; Guanghui Wang; Hiroyuki Kawagishi; Daniela A Malide; Yuesheng Li; Marjan Gucek; Mehdi Pirooznia; Alissa J Nelson; Matthew P Stokes; Jacob Stewart-Ornstein; Steven J Mullett; Stacy G Wendell; Simon C Watkins; Toren Finkel; Yusuke Sekine
PLoS biology, 18(11), e3000981, Nov. 2020, Refereed
Lead

β-Arrestin-Biased AT1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate.
Toshihide Kashihara; Hiroyuki Kawagishi; Tsutomu Nakada; Takuro Numaga-Tomita; Shin Kadota; Elena E Wolf; Cheng-Kun Du; Yuji Shiba; Sachio Morimoto; Mitsuhiko Yamada
JACC. Basic to translational science, 5(11), 1057-1069, Nov. 2020, Refereed, Not invited
Lead

Macrophage fatty acid oxidation inhibits atherosclerosis progression.
Nomura M; Liu J; Yu ZX; Yamazaki T; Yan Y; Kawagishi H; Rovira II; Liu C; Wolfgang MJ; Mukouyama YS; Finkel T
Journal of molecular and cellular cardiology, Jan. 2019, Refereed, Not invited
Lead

Increase in phospholamban content in mouse skeletal muscle after denervation.
Komatsu M; Nakada T; Kawagishi H; Kato H; Yamada M
Journal of muscle research and cell motility, 39(5-6), 163-173, Dec. 2018, Refereed, Not invited
Lead

Prostanoid EP4 receptor-mediated augmentation of I_h currents in Aβ dorsal root ganglion neurons underlies neuropathic pain.
Zhang H; Kashihara T; Nakada T; Tanaka S; Ishida K; Fuseya S; Kawagishi H; Kiyosawa K; Kawamata M; Yamada M
The Journal of pharmacology and experimental therapeutics, 368(1), 50-58, Nov. 2018, Refereed, Not invited
Lead

Sonic hedgehog signaling regulates the mammalian cardiac regenerative response.
Kawagishi H; Xiong J; Rovira II; Pan H; Yan Y; Fleischmann BK; Yamada M; Finkel T
Journal of molecular and cellular cardiology, 123, 180-184, Oct. 2018, Refereed, Not invited
Lead

A Metabolic Basis for Endothelial-to-Mesenchymal Transition.
Xiong J; Kawagishi H; Yan Y; Liu J; Wells QS; Edmunds LR; Fergusson MM; Yu ZX; Rovira II; Brittain EL; Wolfgang MJ; Jurczak MJ; Fessel JP; Finkel T
Molecular cell, 69(4), 689-698.e7, Feb. 2018, Refereed, Not invited
Lead

Elimination of p19ARF-expressing cells enhances pulmonary function in mice.
Michihiro Hashimoto; Azusa Asai; Hiroyuki Kawagishi; Ryuta Mikawa; Yuji Iwashita; Kazuki Kanayama; Kazushi Sugimoto; Tadashi Sato; Mitsuo Maruyama; Masataka Sugimoto
JCI insight, 1(12), e87732, Aug. 2016, Refereed, Not invited
Lead

Loss of HuR leads to senescence-like cytokine induction in rodent fibroblasts by activating NF-kappa B
Michihiro Hashimoto; Takayuki Tsugawa; Hiroyuki Kawagishi; Azusa Asai; Masataka Sugimoto
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1840(10), 3079-3087, Oct. 2014, Refereed, Not invited
Lead

HuR Maintains a Replicative Life Span by Repressing the ARF Tumor Suppressor
Hiroyuki Kawagishi; Michihiro Hashimoto; Hideaki Nakamura; Takayuki Tsugawa; Atsushi Watanabe; Dimitris L. Kontoyiannis; Masataka Sugimoto
MOLECULAR AND CELLULAR BIOLOGY, 33(10), 1886-1900, May 2013, Refereed, Not invited
Lead

Cooperative Role of the RNA-Binding Proteins Hzf and HuR in p53 Activation
Hideaki Nakamura; Hiroyuki Kawagishi; Atsushi Watanabe; Kazushi Sugimoto; Mitsuo Maruyama; Masataka Sugimoto
MOLECULAR AND CELLULAR BIOLOGY, 31(10), 1997-2009, May 2011, Refereed, Not invited
Lead

ARF suppresses tumor angiogenesis through translational control of VEGFA mRNA
Hiroyuki Kawagishi; Hideaki Nakamura; Mitsuo Maruyama; Shuki Mizutani; Kazushi Sugimoto; Masatoshi Takagi; Masataka Sugimoto
Cancer Research, 70(11), 4749-4758, Jun. 2010, Refereed, Not invited
Lead

Hzf regulates adipogenesis through translational control of C/EBPα
Hiroyuki Kawagishi; Takeshi Wakoh; Hatsume Uno; Mitsuo Maruyama; Ayako Moriya; Satoru Morikawa; Hideyuki Okano; Charles J. Sherr; Masatoshi Takagi; Masataka Sugimoto
EMBO Journal, 27(10), 1481-1490, May 2008, Refereed, Not invited
Lead

Adrenomedullin-RAMP2 and -RAMP3 Systems Regulate Cardiac Homeostasis during Cardiovascular Stress
Nanqi Cui; Takayuki Sakurai; Akiko Kamiyoshi; Yuka Ichikawa-Shindo; Hisaka Kawate; Megumu Tanaka; Masaaki Tanaka; Yangxuan Wei; Shinji Kakihara; Yunlu Zhao; Kohsuke Aruga; Hiroyuki Kawagishi; Tsutomu Nakada; Mitsuhiko Yamada; Takayuki Shindo

Loss of HuR leads to senescence-like cytokine induction in rodent fibroblasts by activating NF-kappa B
Michihiro Hashimoto; Takayuki Tsugawa; Hiroyuki Kawagishi; Azusa Asai; Masataka Sugimoto

Cardiotoxicity risk assessment of anti-cancer drugs and future perspectives
Shota Yanagida; Hiroyuki Kawagishi; Yasunari Kanda
Folia Pharmacologica Japonica, 159(2), 83 - 89, 01 Mar. 2024
https://www.jstage.jst.go.jp/article/fpj/159/2/159_23094/_pdf
Lead

New trend on safety pharmacology
諫田泰成; 川岸裕幸
Pharm Tech Japan, 40(9), 2024
Lead

Drug Development Using Human iPSC-Derived Cardiomyocytes and Future Perspectives
Hiroyuki Kawagishi; Shota Yanagida; Yasunari Kanda
Reference Module in Biomedical Sciences, 2024, Refereed
Lead

βアレスチンバイアス性アンジオテンシンII 1型受容体アゴニストによる新たな小児心不全治療戦略の創生.
川岸裕幸; 山田充彦
血管, 2022, Refereed, Invited
Lead, Corresponding

新生児マウス心臓の機能的発達におけるサイトカイン受容体gp130の役割
川岸裕幸; 山田充彦
信州医学雑誌, 2022, Invited
Lead, Corresponding

βアレスチンバイアスAT1受容体アゴニストは新しい乳幼児心不全治療薬の有力候補である。
川岸裕幸; 山田充彦
医学のあゆみ, 276(12), 1137 - 1138, Mar. 2021, Not invited
Lead

A novel way of modification of AT₁ angiotensin receptors to alleviate neonatal and infantile heart failure
Hiroyuki Kawagishi; Mitsuhiko Yamada
Folia Pharmacologica Japonica, 156(6), 351 - 354, 2021
https://www.jstage.jst.go.jp/article/fpj/156/6/156_21059/_pdf
Lead

Unraveling the Truth About Antioxidants: ROS and disease: finding the right balance
Hiroyuki Kawagishi; Toren Finkel
Nature Medicine, 20(7), 711 - 713, Jul. 2014
Lead

癌抑制・細胞老化因子ARFが引き起こす血管新生抑制及び疾患との関わり
川岸 裕幸; 丸山 光生; 高木 正稔; 杉本 昌隆
基礎老化研究, 34(3), 19 - 21, 2010, Not invited
Lead

腫瘍循環器学 ―新しい学際領域の最新知見―
川岸裕幸; 柳田翔太; 諫田泰成, Contributor, XII．特論「ヒトiPS 細胞技術を活用した抗がん薬の心毒性評価法の開発」
日本臨牀, Apr. 2024

老年医学（上巻）-基礎・臨床研究の最新動向-
川岸裕幸; 三河隆太; 杉本昌隆, Joint work, 細胞老化と組織老化
日本臨牀, 2018

Drug Development for Pediatric Heart Failure: Neonatal-Specific Functions of Cardiac Angiotensin Receptor
Hiroyuki Kawagishi; Yasunari Kanda; Mitsuhiko Yamada
2024 Fall International Convention of The Pharmaceutical Society of Korea, Oct. 2024, Invited

AT1アンジオテンシン受容体の生理作用を利用した新規乳幼児心不全治療薬の開発
川岸裕幸; 冨田(沼賀)拓郎; 中田勉; 柴裕司; 森本幸生; 山田充彦
第144回日本薬理学会関東部会, Jun. 2021, Not invited

A novel way of modification of AT1 angiotensin receptors to alleviate pediatric heart failure
Hiroyuki KAWAGISHI; Takuro NUMAGA-TOMITA; Tsutomu NAKADA; Toshihide KASHIHARA; Mitsuhiko YAMADA
第94回日本薬理学会年会, Mar. 2021

Postnatal loss of gp130 caused impaired cardiac contractility accompanied by inhibition of physiological proliferation of cardiomyocytes
Hiroyuki Kawagishi; Tsutomu Nakada; Takuro Numaga-Tomita; Mitsuhiko Yamada
心血管国際研究集会2020, Dec. 2020, Not invited,

アンジオテンシンII 1型受容体ーβアレスチン経路を活性化する小児心不全治療薬の開発
川岸裕幸; 柏原俊英; 冨田(沼賀)拓郎; 中田勉; 山田充彦
第30回日本循環薬理学会, Nov. 2020, Not invited

新たな方法でAT1受容体を利用した小児心不全治療薬の開発
川岸裕幸
第143回日本薬理学会関東部会, Oct. 2020, Invited

βアレスチンバイアスアンジオテンシン１型受容体アゴニストは、新生児特有の持続性陽性変力作用を示す
第142回日本薬理学会関東部会, Jun. 2020, Not invited

新生児マウスにおける、gp130受容体を介した心筋細胞の発達機構
2019年 筋生理の集い, Dec. 2019, Not invited

Physiological role of gp130 receptor in newborn mouse cardiomyocyte development
'MIRACLES' in Cardiovascular Physiology ～Metabolism, Interactions, Regulation, Application, Chemical Biology, Longevity, Exercise and Signaling～, Dec. 2019, Not invited

βアレスチンバイアス アンジオテンシン１型受容体アゴニストは、 新生児マウス心臓において持続的な陽性変力作用を示す
第29回日本循環薬理学会, Nov. 2019, Not invited

βアレスチンバイアスAT1受容体アゴニストは、新生児マウス心臓において持続的な陽性変力作用を示す
第21回応用薬理シンポジウム, Sep. 2019, Not invited

マウス心筋細胞の生下後の機能的最終分化の分子メカニズムの解析
第140回日本薬理学会関東部会, Jul. 2019, Not invited

Sonic Hedgehog signaling regulates the mammalian cardiac regenerative response
9th FAOPS, Mar. 2019, Not invited

Factors inducing final cardiomyocyte maturation in newborn mice
第92回日本薬理学会年会, Mar. 2019, Not invited,

新生児マウスの心臓における、 β-アレスチン選択的アンジオテンシン受容体アゴニストによる陽性変力作用
川岸裕幸
第28回日本循環薬理学会, Dec. 2018, Not invited

新生児マウスの心臓におけるアンジオテンシンII 1型受容体-βアレスチン経路による陽性変力作用
川岸裕幸
第139回日本薬理学会関東部会, Oct. 2018, Not invited

Sonic Hedgehog signaling regulates the mammalian cardiac regenerative response
Hiroyuki KawagishiHiroyuki Kawagishi; Jianhua Xiong; Toren Finkel
18th World Congress of Basic and Clinical Pharmacology, Jul. 2018, Not invited

Sonic Hedgehog signaling regulates the mammalian cardiac regenerative response
Hiroyuki Kawagishi; Jianhua Xiong; Toren Finkel
ConBio2017, Dec. 2017, Not invited

Role of sonic hedgehog signaling in heart regeneration.
Hiroyuki Kawagishi
Leducq annual meeting, Feb. 2017, Not invited

Role of sonic hedgehog signaling in mammalian cardiac regeneration
Hiroyuki KAWAGISHI
国立長寿医療研究センター NCGGセミナー, Feb. 2016, Invited

Role of sonic hedgehog signaling in heart regeneration
Hiroyuki Kawagishi
Leducq annual meeting, Jan. 2016, Not invited

Role of mitochondrial protein CPT1A in sonic hedgehog signaling
Hiroyuki Kawagishi; Jianhua Xiong; Toren Finkel
JSPS-NIH meeting, Oct. 2014, Not invited

HuR maintains replicative lifespan by suppressing ARF tumor suppressor.
Hiroyuki Kawagishi; Hideaki Nakamura; Takayuki Tsugawa; Masataka Sugimoto
名古屋大学GCOEリトリート, Mar. 2012, Not invited

HuR maintains replicative lifespan by repressing ARF tumor suppressor.
Hiroyuki Kawagishi; Hideaki Nakamura; Takayuki Tsugawa; Masataka Sugimoto
第34回分子生物学会年会, Dec. 2011, Not invited

RNA-binding protein HuR suppresses cellular senescence by repressing the translation of ARF mRNA.
Hiroyuki Kawagishi; Masataka Sugimoto
Mechanisms & Models of Cancer Symposium in SALK instate, Aug. 2011, Not invited

HuR maintains replicative lifespan by repressing ARF tumor suppressor.
Hiroyuki Kawagishi
FANTASY, Feb. 2011, 第一三共株式会社, Not invited

ARF tumor suppressor regulates tumor angiogenesis through translational control of VEGFA mRNA.
Kawagishi H; Maruyama M; Takagi M; Sugimoto M
第32回分子生物学会年会, Dec. 2009, Not invited

ARF tumor suppressor inhibits the translation of VEGF mRNA.
Hiroyuki Kawagishi
FANTASY, Jan. 2008, 第一三共株式会社, Not invited

ARF tumor suppressor inhibits the translation of VEGF mRNA.
川岸裕幸; 高木正稔; 杉本昌隆
第30回日本分子生物学会年会・第80回日本生化学会大会合同大会, Dec. 2007, Not invited

ARF tumor suppressor regulates the translation of VEGF mRNA.
川岸裕幸; 丸山光生; 高木正稔; 杉本昌隆
第9回日本RNA学会年会, Aug. 2007, Not invited

2024 - Present
肝細胞研究会

Apr. 2023 - Present
日本毒性学会

Apr. 2023 - Present
日本薬学会

2023 - Present
SPS

2023 - Present
日本安全性薬理学会

Jun. 2020 - Present
日本生理学会

Jun. 2020 - Present
日本基礎老化学会

2018 - Present
THE JAPANESE PHARMACOLOGICAL SOCIETY

Mar. 2021 - Apr. 2023
日本心脈管作動物質学会

2018 - 2023
Japanese Association of Cardiovascular Pharmacology

2022
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

2019
International Society for Heart Research

新生児低血糖症における心臓の未知の生理的役割とその分子機構の解明
科学研究費補助金, 日本学術振興会 科学研究費助成事業, 基盤研究(C)
2021 - 2023

低出生体重児の子宮外後腎分化誘導法の開発
バイエル薬品株式会社アカデミックサポート
2021

Developmental Origins of Health and DiseaseとしてのAT1受容体による腎脈管・血管形成誘導メカニズムの解明
公益財団法人日本応用酵素協会: Vascular Biology Innovation に関する研究助成(VBIC)
2021

AT1アンジオテンシン受容体-βアレスチン系を活性化する新規小児心不全治療薬開発
公益財団法人日本心臓財団: 第10回日本心臓財団入澤宏・彩 記念研究奨励
2020

βアレスチン選択的アンジオテンシン受容体アゴニストによる新規小児心不全治療薬の開発
公益財団法人宮田心臓病研究振興基金: 未成年心臓血管病の学究等に対する奨励金
2020

新生児期に起こる心筋細胞の分裂増殖の分子メカニズム
一般財団法人長野県科学振興会
2020

新生児期のアンジオテンシンIIによる副腎髄質カテコラミン興奮分泌機構の制御
公益財団法人信州医学振興会
2020

抗腫瘍薬治療による晩期心機能障害の発生機序の解明
公益財団法人がんの子どもを守る会: 2020年度治療研究助成金
2020

アデノ随伴ウイルスを用いた心臓特異的遺伝子抑制による心筋細胞成熟化因子の同定
科学研究費補助金, 日本学術振興会 科学研究費助成事業, 若手研究
2019

マウス心筋細胞の機能的最終分化におけるgp130シグナルの役割
アイバワークス医学研究者支援事業
2019

マウス個体を用いた心筋細胞の成熟化因子の探索
科学研究費補助金, 日本学術振興会 科学研究費助成事業, 研究活動スタート支援
2018 - 2019

マウス個体を用いた心筋細胞成熟化メカニズムの解明
アイバワークス 医学研究者支援事業
2018