MIYAZAKI Daigo
Shinshu University Hospital Intractable Disease Care Center
Senior Assistant Professor
Researcher Information
Research activity information
Paper
- Becker muscular dystrophy mice showed site-specific decay of type IIa fibers with capillary change in skeletal muscle
Daigo Miyazaki, Mitsuto Sato, Naoko Shiba, Takahiro Yoshizawa, Akinori Nakamura
eLife, https://doi.org/10.7554/eLife.100665.1, 23 Oct. 2024
Lead
- Natural history of Becker muscular dystrophy: a multicenter study of 225 patients
Akinori Nakamura, Tsuyoshi Matsumura, Katsuhisa Ogata, Madoka Mori-Yoshimura, Eri Takeshita, Koichi Kimura, Takahiro Kawashim, Yui Tomo, Hajime Arahata, Daigo Miyazaki, Yasuhiro Takeshima, Toshiaki Takahashi, Keiko Ishigaki, Satoshi Kuru, Akiko Wakisaka, Hiroyuki Awan , Michinori Funato, Tatsuharu Sato, Yoshiaki Saito, Hiroto Takada, Kazuma Sugie, Michio Kobayashi, Shiro Ozasa, Tatsuya Fujii, Yoshihiro Maegaki, Hideki Oi, Hisateru Tachimori, Hirofumi Komaki
Ann Clin Transl Neurol, 10 Dec. 2023 - Efficacy of exon-skipping therapy for DMD cardiomyopathy with mutations in actin binding domain 1
Naoko Shiba, Xiao Yang, Mitsuto Sato, Shin Kadota, Yota Suzuki, Masahiro Agata, Kohei Nagamine, Masaki Izumi, Yusuke Honda, Tomoya Koganehira, Hideki Kobayashi, Hajime Ichimura, Shinichiro Chuma, Junichi Nakai, Shugo Tohyama, Keiichi Fukuda, Daigo Miyazaki, Akinori Nakamura, Yuji Shiba
Mol Ther Nucleic Acids, 19 Oct. 2023 - Restoring Dystrophin Expression with Duchenne Muscular Dystrophy Exon 45 Skipping in Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Mitsuto Sato, Naoko Shiba, Daigo Miyazaki, Yuji Shiba, Akinori Nakamura
Methods Mol Biol, 2023 - Clinical characteristics of patients with myalgia as the initial manifestation of small and medium-sized vasculitis: a retrospective study
Ushiyama S, ShimojimaY, Ueno K, Kishida D, Miyazaki D, Sekijima Y
Rheumatol Int, 40(10), 1667-1674, 2020 - Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes
Mitsuto Sato, Naoko Shiba, Daigo Miyazaki, Yuji Shiba, Yusuke Echigoya, Toshifumi Yokota, Hotake Takizawa, Yoshitsugu Aoki, Shin'ichi Takeda, Akinori Nakamura
Biochem Biophys Res Commun, 26 Nov. 2019 - Comparison of the phenotypes of patients harboring in-frame deletions starting at exon 45 in the Duchenne muscular dystrophy gene indicates potential for the development of exon skipping therapy.
Nakamura A, Shiba N, Miyazaki D, Nishizawa H, Inaba Y, Fueki N, Maruyama R, Echigoya Y, Yokota T.
J Hum Genet, 62(4), 459-463, Apr. 2017 - Increasing Incidence and Age at Onset of Amyotrophic Lateral Sclerosis in Nagano Prefecture, Japan
Chinatsu KOBAYASHI, Daigo MIYAZAKI, Tomomi KINOSHITA, Akiyo HINENO, Akinori NAKAMURA
信州医学雑誌, 64(5), 239-246, Nov. 2016 - Elevation of serum heat-shock protein levels in amyotrophic lateral sclerosis.
Miyazaki D, Nakamura A, Hineno A, Kobayashi C, Kinoshita T, Yoshida K, Ikeda S.
Neurol Sci, 37(8), 1277-81, Aug. 2016 - Deletion of exons 3-9 encompassing a mutational hot spot in the DMD gene presents an asymptomatic phenotype, indicating a target region for multiexon skipping therapy.
Nakamura A, Fueki N, Shiba N, Motoki H, Miyazaki D, Nishizawa H, Echigoya Y, Yokota T, Aoki Y, Takeda S.
J Hum Genet, 61(7), 663-7, Jul. 2016 - Crossed Cerebellar Diaschisis in Status Epilepticus.
Miyazaki D, Fukushima K, Nakahara A, Kodaira M, Mochizuki K, Kaneko K, Kaneko T, Sekijima Y, Ikeda S.
Intern Med, 55(12), 1649-51, Jun. 2016 - Differential roles of MMP-9 in early and late stages of dystrophic muscles in a mouse model of Duchenne muscular dystrophy.
1. Shiba N, Miyazaki D, Yoshizawa T, Fukushima K, Shiba Y, Inaba Y, Imamura M, Takeda S, Koike K, Nakamura A.
2015 - Matrix metalloproteinase-2 ablation in dystrophin-deficient mdx muscles reduces angiogenesis resulting in impaired growth of regenerated muscle fibers
Miyazaki, D; Nakamura, A; Fukushima, K; Yoshida, K; Takeda, S; Ikeda, S
HUMAN MOLECULAR GENETICS, 20(9), 1787-1799, May 2011
Lectures, oral presentations, etc.
- Becker muscular dystrophy mouse models revealed nNOS reduction with capillary change and decreased type IIa fibers in skeletal muscle
Daigo Miyazaki, Mitsuto Sato, Naoko Shiba, Takahiro Yoshizawa, Akinori Nakamura
第22回アジアオセアニア筋学センター学術集会/第10回日本筋学会学術集会 合同学術大会, 13 Sep. 2024BMD mouse having severe-form exon deletion showed early muscle degeneration with type-IIa reduction
Daigo Miyazaki, Mitsuto Sato, Naoko Shiba, Takahiro Yoshizawa, Akinori Nakamura
The 65rd Annual Meeting of the Japanese Society of Neurology, 31 May 2024重症度の異なるエクソン欠失を持つベッカー型筋ジストロフィーモデルマウスの表現型および病理学的比較検討
宮崎大吾、佐藤充人、柴直子、吉沢隆浩、中村昭則
第9回日本筋学会学術集会, 2023重症度の異なる複数のベッカー型筋ジストロフィーモデルマウスを用いた重症化機序に関する研究
宮崎大吾、佐藤充人、柴直子、吉沢隆浩、中村昭則
日本筋学会学術集会, 06 Aug. 2022Study about genome editing mouse models carrying exon-deletion s of severe- and mild-form BMD
Daigo Miyazaki,Mitsuto Sato,Naoko Shiba,Takahiro Yoshizawa,Akinori Nakamura
日本神経学会学術大会, 18 May 2022重症度の異なるエクソン欠失を持つゲノム編集マウスを用いたベッカー型筋ジストロフィー重症化に関する研究
宮崎大吾、佐藤充人、柴直子、吉沢隆浩、中村昭則
日本筋学会学術集会, 12 Dec. 2021TMSB4X and IGF2 down-regulation in dystrophin-deficient cardiomyocyte derived from DMD
Daigo Miyazaki,Naoko Shiba,Mitsuto Sato,Yuji Shiba,Yusuke Echigoya,Toshifumi Yokota,Yoshitaka Mizobe,Yoshitsugu Aoki,Shinichi Takeda,Akinori Nakamura
日本神経学会学術大会, 22 May 2021当科で経験したパーキンソン病患者におけるL-ドパ持続経腸療法の検討
池田淳司、近藤恭史、宮崎大吾、関島良樹
日本神経学会学術大会, 19 May 2021Exon 45 skipping therapy of induced pluripotent stem cells from a DMD patient with exon 46-55 deletion
Mitsuto Sato, Daigo Miyazaki, Yuji Shiba, Yusuke Echigoya, Toshifumi Yokota, Yoshitsugu Aoki, Shin’ichi Takeda, Akinori Nakamura
World congress of neurology (WCN) 2017, Sep. 2017Dystrophin-deficient cardiomyocyte derived from Duchenne Muscular Dystrophy specific induced pluripotent stem cells carrying the deletion of exon 46-55 in DMD gene
Daigo Miyazaki, Mitsuto Sato, Yuji Shiba, Yusuke Echigoya, Toshifumi Yokota, Yoshitsugu Aoki, Shinichi Takeda, Akinori Nakamura
World congress of neurology (WCN) 2017, Sep. 2017Becker muscular dystrophyのDMD遺伝子変異Hot Spotにおける遺伝型一表現型の検討
宮崎 大吾, 中村 昭則, 柴 直子, 稲葉 雄二, 笛木 昇, 古庄 知己, 池田 修一
臨床神経学 56 Suppl. S420, Dec. 2016, 日本神経学会Elevation of serum Heat-Shock Protein (HSP) 70 and 90 in patients with ALS
Daigo Miyazaki,1 Akinori Nakamura,1,2 Chinatsu Kobayashi,1 Tomomi Kinoshita,1 Akiyo Hineno,3 Kunihiro Yoshida,4 Shu-ichi Ikeda
日本神経学会総会, 2015Elevated serum levels of Heat-Shock Protein (HSP) 70 and 90 in patients with ALS
Daigo Miyazaki,1 Akinori Nakamura,1,2 Chinatsu Kobayashi,1 Tomomi Kinoshita,1 Akiyo Hineno,3 Kunihiro Yoshida,4 Shu-ichi Ikeda
World conress of neurology 2015. chile, 2015