Doctor of Medicine, Shinshu University (Japan)

Orthopedics, Orthopaedic surgery

Rehabilitation science, Rehabilitation science/Welfare engineering

Biomedical engineering, Biomedical engineering/ Biomaterial science and engineering

Nanobioscience, Nanobioscience

Medical biochemistry, General medical chemistry

1988, Shinshu University, School of Medicine

Bone-regeneration therapy using biodegradable scaffolds: calcium phosphate bioceramics and biodegradable polymers
Aoki K, Ideta H, Komatsu Y, Tanaka A, Kito M, Takahashi J, Suzuki S, Saito N
Bioengineering-Basel, 11, 180, 2024
Last

Calcium-mediated zoledronate loading onto carbon nanohorns
Nakamura M, Yamamoto Y, Zhang M, Ueda K, Aoki K, Saito N, Yudasaka M
Nanoscale, 16, 16632, 2024

Development of phosphate-treated PEEK implants with high osseointegration
Usuda Y, Okihara T, Moriyama S, Uemura T, Kamanaka T, Omi AW, Saito N, Takahashi J, Aoki K, Nishimura N
Mater Today Commun, 38, 107717, 2024

Biocompatibility evaluation of carbon nanohorns in bone tissues
Ueda K, Ma C, Izumiya M, Kuroda C, Ishida H, Uemura T, Saito N, Aoki K, Haniu H
Nanomaterials, 13, 244, 2023

Future prospects for clinical applications of nanocarbons focusing on carbon nanotubes
Saito N, Haniu H, Aoki K, Nishimura N, Uemura T
Adv Sci, 2022, 2201214, 2022
Lead, Corresponding

Current methods in the study of nanomaterials for bone regeneration. Nanomaterials-Basal
Tanaka M, Izumiya M, Haniu H, Ueda K, Ma C, Ueshita K, Ideta H, Sobajima A, Uchiyama S, Takahashi J, Saito N
Nanomaterials-Basal, 12, 1195, 2022
Last

Bisphosphonate type-dependent cell viability suppressive effects of carbon nanohorn–calcium phosphate–bisphosphonate nanocomposites
Nakamura M, Ueda K, Yamamoto Y, Aoki K, Zhang M, Saito N, Yudasaka M
Biomater Sci-UK, 10, 6037, 2022
Corresponding

A new remnant preservation technique reduces bone tunnel enlargement after anatomic double‑bundle anterior cruciate ligament econstruction
Koyama S, Tensho K, Shimodaira H, Iwaasa T, Kumaki D, Horiuchi H, Saito N, Takahashi J
Knee Surg Sport Tr A, 30, 2020-2028, 2022

Potential risk of medial cortex perforation due to peg position of morphometric tibial component in unicompartmental knee arthroplasty: a computer simulation study
Tensho K, Koyama S, Iwaasa T, Shimodaira H, Saito N, Horiuchi H, Takahashi J
Knee Surg Sport Tr A, 30, 536-544, 2022

Future Prospects for Clinical Applications of Nanocarbons Focusing on Carbon Nanotubes.
Saito N, Haniu H, Aoki K, Nishimura N, Uemura T.
Adv. Sci., 2022, 20221214, 2022
Lead, Corresponding

Bisphosphonate type-dependent cell viability suppressive effects of carbon nanohorn–calcium phosphate–bisphosphonate nanocomposites.
Nakamura M, Ueda K, Yamamoto Y, Aoki K, Zhang M, Saito N, Yudasaka M.
Biomater Sci-UK, 10, 6037, 2022
Corresponding

Potential risk of medial cortex perforation due to peg position of morphometric tibial component in unicompartmental knee arthroplasty: a computer simulation study.
Tensho K, Koyama S, Iwaasa T, Shimodaira H, Saito N, Horiuchi H, Takahashi J.
Knee Surg Sport Tr A, 2022, Refereed

A new remnant preservation technique reduces bone tunnel enlargement after anatomic double‑bundle anterior cruciate ligament econstruction.
Koyama S, Tensho K, Shimodaira H, Iwaasa T, Kumaki D, Horiuchi H, Saito N, Takahashi J.
Knee Surg Sport Tr A, 30, 2020-2028, 2022

Biokinetic Evaluation of Contrast Media Loaded Carbon Nanotubes Using a Radiographic Device
Takasaka M, Kobayashi S, Usui Y, Haniu H, Tsuruoka S, Aoki K, Saito N
Toxics, 9, 331, 2021
Last, Corresponding

Isolated lymphatic vessel lumen perfusion system for assessing nanomaterial movements and nanomaterial-induced responses in lymphatic vessels
Kuroda C, Ajima K, Ueda K, Sobajima A, Yoshida K, Kamanaka T, Sasaki J, Ishida H, Haniu H, Okamoto M, Aoki K, Kato H, Saito N
NANO TODAY, 36, 101018, 2021
Last, Corresponding

Ibandronate-loaded carbon nanohorns fabricated using calcium phosphates as a mediator and their effects on macrophages and osteoclasts
Nakamura M, Ueda K, Yamamoto Y, Aoki K, Zhang M, Saito N, Yudasaka M
ACS Appl Mater Interfaces, 13, 3701-3712, 2021
Corresponding

Clinical outcome of a new remnant augmentation technique with anatomical double-bundle anterior cruciate ligament reconstruction: Comparison among remnant preservation, resection, and absent groups.
Iwaasa T, Tensho K, Koyama S, Shimodaira H, Horiuchi H, Saito N, Takahashi J.
Asia Pac J Sports Med Arthrosc Rehabil Technol, 25, 22-29, 2021

Evaluation of MC3T3-E1 Cell Osteogenesis in Different Cell Culture Media
Izumiya M, Haniu M, Ueda K, Ishida H, Ma C, Ideta H, Sobajima A, Ueshiba K, Uemura T, Saito N, H, Haniu H.
Int J Mol Sci, 22, 7752, 2021

Structurally different lysophosphatidylethanolamine species stimulate neurite outgrowth in cultured cortical neurons via distinct G-protein-coupled receptors and signaling cascades
Hisano K, Kawase S, Mimura T, Yoshida H, Yamada H, Haniu H, Tsukahara T, Kurihara T, Matsuda Y, Saito N, Uemura T
Biochem Biophys Res Commun, 1, 179-185, 2021

Antitumor Effect of Sclerostin against Osteosarcoma.
Ideta H, Yoshida K, Okamoto M, Sasaki J, Kito M, Aoki K, Yoshimura Y, Suzuki S, Tanaka A, Takazawa A, Haniu H, Uemura T, Takizawa T, Sobajima A, Kamanaka T, Takahashi J, Kato H, Saito N.
Cancer, 13(23), 6015, 2021

Multiwall Carbon Nanotube Composites as Artificial Joint Materials
Sobajima A, Okihara T, Moriyama S, Nishimura N, Osawa T, Miyamae M, Haniu H, Aoki K, Tanaka M, Usui Y, Sako K, Kato H, Saito N
ACS Biomater Sci Eng, 6, 7032-7040, 2020
Last, Corresponding

Carbon nanotube-based biomaterials for orthopaedic applications
Aoki K, Ogihara N, Tanaka M, Haniu H, Saito N
J Mater Chem B, 8, 9227-9238, 2020
Last, Corresponding

Carbon fibers for treatment of cancer metastasis in bone.
Kamanaka T, Haniu H, Tanaka M, Takizawa T, Aoki K, Okamoto M, Sobajima A, Yoshida K, Ideta H, Mimura T, Ishida H, Ueda K, Uemura T, Kim J. H., Kim Y. A., Kato H, Saito N.
RSC Adv, 10, 33071-33079, 2020
Last, Corresponding

Aperture elongation of the femoral tunnel on the lateral cortex in anatomical double-bundle anterior cruciate ligament reconstruction using the outside-in technique.
Tensho K, Akaoka Y, Iwaasa T, Koyama S, Shimodaira H, Horiuchi H, Saito N.
MEDICINE, 99, e22053, 2020, Refereed
Last

Cellular Responses of Human Lymphatic Endothelial Cells to Carbon Nanomaterials.
Sano M, Izumiya M, Haniu H, Ueda K, Konishi K, Ishida H, Kuroda C, Uemura T, Aoki K, Matsuda Y, Saito N.
Nanomaterials-Basal, 14, 1374, 2020, Refereed
Last

Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells.
Yoshida K, Okamoto M, Sasaki J, Kuroda C, Ishida H, Ueda K, Ideta H, Kamanaka T, Sobajima A, Takizawa T, Tanaka M, Aoki K, Uemura T, Kato H, Haniu H, Saito N.
BMC CANCER, 20, 25, 2020, Refereed
Last, Corresponding

Anatomical Remnant-Preserving Double-Bundle ACL Reconstruction with a New Remnant Augmentation Technique.
Tensho K, Iwaasa T, Shimodaira H, Koyama S, Horiuchi H, Takahashi J, Saito N.
Arthrosc Tech, 9, e283-e290, 2020, Refereed
Last

A Review of T-Cell Related Therapy for Osteosarcoma.
Yoshida K, Okamoto M, Aoki K, Takahashi J, Saito N.
Int J Mol Sci, 21, 4877, 2020, Refereed
Last, Corresponding

Applications of Carbon Nanotubes in Bone Regenerative Medicine.
Tanaka M, Aoki K, Haniu H, Kamanaka T, Takizawa T, Sobajima A, Yoshida K, Okamoto M, Kato H, Saito N.
Nanomaterials-Basal, 10, 659, 2020, Refereed
Last

The use of electrospun nanofibers in bone regeneration, with a focus on carbon fibers.
Aoki K, Haniu H, Kim YA, Saito N.
Nanomaterials-Basal, 10, 562, 2020, Refereed
Last

Biocompatibility and carcinogenicity of carbon nanotubes as biomaterials.
Aoki K, Saito N
Nanomaterials-Basal, 10, 264, 2020, Refereed

Biodegradable polymers as drug delivery systems for bone regeneration.
Aoki K, Saito N
Pharmaceutics, 12, 95, 2020, Refereed

The interrelationship between anterior cruciate ligament tibial footprint and anterolateral meniscal root insertions: quantitative, morphological and positional analyses using 3-dimensional computed tomography images.
Tensho K, Iwaasa T, Koyama S, Yoshida K, Shimodaira H, Horiuchi H, Kato H, Saito N, Fukushima N.
Knee, 26, 969-977, 2019, Refereed

In Vitro and In Vivo Evaluation of Starfish Bone-Derived β-Tricalcium Phosphate as a Bone Substitute Material.
Ishida H, Haniu H, Takeuchi A, Ueda K, Sano M, Tanaka M, Takizawa T, Sobajima A, Kamanaka T, Saito N.
Materials, 11, E1881, 2019, Refereed

Organ accumulation and carcinogenicity of highly dispersed multi-walled carbon nanotubes administered intravenously in transgenic rasH2 mice.
Sobajima A, Haniu H, Nomura H, Tanaka M, Takizawa T, Kamanaka T, Aoki K, Okamoto M, Yoshida K, Sasaki J, Ajima K, Kuroda C, Ishida H, Okano S, Ueda K, Kato H, Saito N.
Int J Nanomed, 2019(14), 6465–6480, 2019, Refereed

Clinical outcome of osteosarcoma and its correlation with programmed death-ligand 1 and T cell activation markers.
Yoshida K, Okamoto M, Sasaki J, Kuroda C, Ishida H, Ueda K, Okano S, Ideta H, Kamanaka T, Sobajima A, Takizawa T, Kito M, Aoki K, Uemura T, Haniu H, Kato H, Saito N.
OncoTargets Ther, 12, 2513-2518, 2019, Refereed

A Case of Prefemoral Fat Pad Impingement Syndrome Caused by Hyperplastic Fat Pad.
Koyama S, Tensho K, Shimodaira H, Iwaasa T, Horiuch H, Kato H, Saito N.
Case Rep Orthop, 2018, 3583049, 2018, Refereed

The acetabular fossa may not be located at the true center of the acetabulum: a detailed analysis using preoperative CT images
Shimodaira H, Tensho K, Akaoka Y, Koyama S, Maruyama M, Kato H, Saito N
J Bone Joint Surg Am, 100, e27, 2018, Refereed

Lateralization of the tibial tubercle in recurrent patellar dislocation: verification using multiple evaluative methods for the tibial tubercle
Tensho K, Shimodaira H, Akaoka Y, Koyama S, Hatanaka D, Ikegami S, Kato H, Saito N
J Bone Joint Surg Am, 100, e58, 2018, Refereed

Different aggregation and shape characteristics of carbon materials affect biological responses in RAW264 cells
Kuroda C, Ueda K, Haniu H, Ishida H, Okano S, Takizawa T, Sobajima A, Kamanaka H, Yoshida K, Okamoto M, Tsukahara T, Matsuda Y, Aoki K, Kato H, Saito N
Int J Nanomed, 13, 6079-6088, 2018, Refereed

Physico-Chemical, In Vitro, and In Vivo Evaluation of a 3D Unidirectional Porous Hydroxyapatite Scaffold for Bone Regeneration
Tanaka M, Haniu H, Kamanaka T, Takizawa T, Sobajima A, Yoshida K, Aoki K, Okamoto M, Kato H, Saito N
Materials, 10, 33, 2017, Refereed

In Vitro and In Vivo Evaluation of a Three-Dimensional Porous Multi-Walled Carbon Nanotube Scaffold for Bone Regeneration
Tanaka M, Sato Y, Zhang M, Haniu H, Okamoto M, Aoki K, Takizawa T, Yoshida K, Sobajima A, Kamanaka T, Kato H, Saito N
Nanomaterials-Basel, l7, 46, 2017, Refereed

Impact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model
Ogasawara T, Okano S, Ichimura H, Kadota S, Tanaka Y, Minami I, Uesugi M, Wada Y, Saito N, Okada K, Kuwahara K, Shiba Y
Sci Rep-UK, 7, 8630, 2017, Refereed

Titanium fiber plates for bone tissue repair
Takizawa T, Nakayama N, Haniu H, Aoki K, Okamoto M, Nomura H, Tanaka M, Sobajima A, Yoshida K, Kamanaka T, Ajima K, Oishi A, Kuroda C, Ishida H, Okano S, Kobayashi S, Kato H, Saito N
Adv Mater, 30, 1703608, 2017, Refereed

A three-dimensional block structure consisting exclusively of carbon nanotubes serving as bone regeneration scaffold and as bone defect filler
Tanaka M, Sato Y, Haniu H, Nomura H, Kobayashi S, Takanashi S, Okamoto M, Takizawa T, Aoki K, Usui Y, Oishi A, Kato H, Saito N
PLOS ONE, 12, e0172601, 2017, Refereed

Remnant-preserving tibial tunnel positioning using anatomical landmarks in double-bundle anterior cruciate ligament reconstruction.
Shimodaira H, Tensho K, Akaoka Y, Takanashi S, Kato H, Saito N.
Arthroscopy, 32(9), 1822-1830, 2016

The dispersion state of tangled multi-walled carbon nanotubes affects their cytotoxicity.
Kuroda C, Haniu H, Ajima K, Tanaka M, Sobajima A, Ishida H, Tsukahara T, Matsuda Y, Aoki K, Kato H, Saito N.
Nanomaterials-Basel., 6, 219, 2016

Differentiation of chemical reaction activity of various carbon nanotubes using redox potential: Classification by physical and chemical structures
Tsuruoka S, Matsumoto H, Castranova V, Porter DW, Yanagisawa T, Saito N, Kobayashi S, Endo M
Carbon, 95, 302-308, Dec. 2015

Radical scavenging reaction kinetics with multi-walled carbon nanotubes
Tsuruoka S, Matsumoto H, Koyama K, Akiba E, Yanagisawa T, Cassee FR, Saito N, Usui Y, Kobayashi S, Porter DW, Castranova V, Endo M
Carbon, 83, 232-239, Mar. 2015

What Components Comprise the Measurement of the Tibial Tuberosity-Trochlear Groove Distance in a Patellar Dislocation Population?
Tensho K, Akaoka Y, Shimodaira H, Takanashi S, Ikegami S, Kato H, Saito N
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 97(17), 1441-1448, 2015

Influence of pmsa-based polymer on the settling velocity of cnt in aqueous media.
Nishimura N, Takeda S, Teranishi T, Hayashi H, Saito N, Kishimoto A.
Mater Trans, 56(12), 2006-2009, 2015

Endocytosis of Multiwalled Carbon Nanotubes in Bronchial Epithelial and Mesothelial Cells
Maruyama K, Haniu H, Saito N, Matsuda Y, Tsukahara T, Kobayashi S, Tanaka M, Aoki K, Takanashi S, Okamoto M, Kato H
BioMed Research International, 2015, 793186, 2015

An advanced in-situ imaging method using heavy metal doped hollow tubes to evaluate the biokinetics of carbon nanotubes in vivo
Kobayashi S, Tsuruoka S, Usui Y, Haniu H, Aoki K, Takanashi S, Okamoto M, Nomura H, Tanaka M, Aiso S, Saito M, Kato H, Saito N
NPG Asia Materials, 7, e203, 2015

Specific biological responses of the synovial membrane to carbon nanotubes
Nomura H, Takanashi S, Tanaka M, Haniu H, Aoki K, Okamoto M, Kobayashi S, Takizawa T, Usui Y, Oishi A, Kato H, Saito N
SCIENTIFIC REPORTS, 5, 14314, 2015

Safe Clinical Use of Carbon Nanotubes as Innovative Biomaterials
Saito, N; Haniu, H; Usui, Y; Aoki, K; Hara, K; Takanashi, S; Shimizu, M; Narita, N; Okamoto, M; Kobayashi, S; Nomura, H; Kato, H; Nishimura, N; Taruta, S; Endo, M
CHEMICAL REVIEWS, 114(11), 6040-6079, Jun. 2014

Bony Landmarks of the Anterior Cruciate Ligament Tibial Footprint A Detailed Analysis Comparing 3-Dimensional Computed Tomography Images to Visual and Histological Evaluations
Tensho, K; Shimodaira, H; Aoki, T; Narita, N; Kato, H; Kakegawa, A; Fukushima, N; Moriizumi, T; Fujii, M; Fujinaga, Y; Saito, N
AMERICAN JOURNAL OF SPORTS MEDICINE, 42(6), 1433-1440, Jun. 2014

Influence of CNF content on microstructure and fracture toughness of CNF/alumina composites
Ueda, N; Yamakami, T; Yamaguchi, T; Usui, Y; Aoki, K; Endo, M; Saito, N; Taruta, S
Journal of the Ceramic Society of Japan, 122(1424), 292-299, Apr. 2014

Noncanonical Wnt5a enhances Wnt/beta-catenin signaling during osteoblastogenesis
Okamoto, M; Udagawa, N; Uehara, S; Maeda, K; Yamashita, T; Nakamichi, Y; Kato, H; Saito, N; Minami, Y; Takahashi, N; Kobayashi, Y
SCIENTIFIC REPORTS, 4, 4493, Mar. 2014

Snapping pes syndrome after total knee arthroplasty
Tensho K, Aoki T, Morioka S, Narita N, Kato H, Saito N
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 22(1), 192-194, Jan. 2014

Early post-operative intra-tunnel migration of the EndoButton after anatomical double-bundle anterior cruciate ligament reconstruction
Akaoka Y, Tensho K, Shimodaira H, Aoki T, Takanashi S, Kato H, Saito N
JBJS case connector, 4(4), e88, 2014

Biological responses according to the shape and size of carbon nanotubes in BEAS-2B and MESO-1 cells
Haniu, H; Saito, N; Matsuda, Y; Tsukahara, T; Usui, Y; Maruyama, K; Takanashi, S; Aoki, K; Kobayashi, S; Nomura, H; Tanaka, M; Okamoto, M; Kato, H
INTERNATIONAL JOURNAL OF NANOMEDICINE, 9, 1979-1990, 2014

Effect of Aspect Ratio on the Internal Structure of Titanium Fiber Formed by the Compression Shearing Method at Room Temperature
Nakayama N, Izawa N, Horita M, Saito N, Miki H, Takeishi H
Journal of the Japanese Society for Experimental Mechanics, 13(Special Issue), s126-S130, 2013

Culture medium type affects endocytosis of multi-walled carbon nanotubes in BEAS-2B cells and subsequent biological response
Haniu, Hisao; Saito, Naoto; Matsuda, Yoshikazu; Tsukahara, Tamotsu; Maruyama, Kayo; Usui, Yuki; Aoki, Kaoru; Takanashi, Seiji; Kobayashi, Shinsuke; Nomura, Hiroki; Okamoto, Masanori; Shimizu, Masayuki; Kato, Hiroyuki
Toxicology in Vitro, 27(6), 1679-1685, 2013

Biocompatibility and bone tissue compatibility of alumina ceramics reinforced with carbon nanotubes
Ogihara N, Usui Y, Aoki K, Shimizu M, Narita N, Hara K, Nakamura K, Ishigaki N, Takanashi S, Okamoto M, Kato H, Haniu H, Ogiwara N, Nakayama N, Taruta S, Saito N.
NANOMEDICINE, 7, 981-993, 2012

Carbon nanotubes innovate on medical technology
Usui Y, Haniu H, Tsuruoka S, Saito N
MEDICINAL CHEMISTRY, 2, 1-6, 2012

Carbon nanotubes induce bone calcification by bidirectional interaction with osteoblasts
Shimizu M, Kobayashi Y, Mizoguchi T, Nakamura H, Kawahara I, Narita N, Usui Y, Aoki K, Hara K, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Kato H, Kawakubo M, Dohi Y, Taruta S, Kim YA, Endo M, Ozawa H, Udagawa N, Takahashi N, Saito N
ADVANCED MATERIALS, 24, 2176-2185, 2012

Effect of shearing strain on mechanical properties of titanium thin plate by compression shearing method at room temperature.
Horita M, Nakayama N, Saito N, Miki H, Miyazaki T, Takeishi H.
Steel Research International, Special Edition Metal Forming, 803-806, 2012

Microstructure development and fracture toughness of acid-treated carbon nanofibers/alumina composites
Ueda N, Yamakami T, Yamaguchi T, Kitajima K, Usui Y, Aoki K, Endo M, Saito N, Taruta S
Journal of the Ceramic Society of Japan, 120(12), 560-568, 2012

Manufacturing strategy for multi-walled carbon nanotubes as a biocompatible and innovative material
Haniu H, Saito N, Matsuda Y, Usui Y, Aoki K, ShimizuM, Ogihara N, Hara K, Takanashi S, Okamoto M, Nakamura K, Ishigaki N, Tsukahara T, Kato H.
Journal of Nanotechnology, 937819, 1-6, 2012

Basic Potentialof Carbon Nanotubes in Tissue Engineering Applications
Haniu, Hisao; Saito, Naoto; Matsuda, Yoshikazu; Tsukahara, Tamotsu; Usui, Yuki; Narita, Nobuyo; Hara, Kazuo; Aoki, Kaoru; Shimizu, Masayuki; Ogihara, Nobuhide; Takanashi, Seiji; Okamoto, Masanori; Kobayashi, Shinsuke; Ishigaki, Norio; Nakamura, Koichi; Kato, Hiroyuki
Journal of Nanomaterials, 2012, 34374, 2012

Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice
Takanashi S, Hara K, Aoki K, Usui Y, Shimizu M, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Okamoto M, Kobayashi S, Kato H, Sano K, Nishimura N, Tsutsumi H, Machida K Saito N
SCIENTIFIC REPORTS, 2, 498, 2012

Application of carbon fibers to biomaterials: New era of nano-level control of carbon fibers after 30-years of development
Saito N, Aoki K, Usui Y, Shimizu M,Hara K, Narita N, Ogihara N,Nakamura K, Ishigaki N, Kato H, Haniu H, Taruta S, Kim YA, Endo M.
CHEMICAL SOCIETY REVIEWS, 40(7), 3824-3834, 2011

Analysis of pelvic movement in the elderly duringwalking using a posture monitoring system equipped with a triaxial accelerometer and a gyroscope
Ishigaki N, Kimura T, Usui Y, Aoki K, Narita N, Shimizu M, Hara K, Ogihara N, Nakamura K, Kato H, Ohira M, Yokokawa Y, Miyoshi K, Murakami N, Okada S, Nakamura T, Saito N.
Journal of Biomechanics, 44, 1788-1792, 2011

Evaluation of CNTtoxicity in comparison to tattoo ink nanoparticles for use as a biomaterial
Hara K, Aoki K, Usui Y, Shimizu M, Narita N, Ogihara N, Nakamura K, Ishigaki N, Sano K, Haniu H, Kato H, Nishimura N, Kim YA, Taruta S, Saito N.
Materials Today, 14, 434-440, 2011

Anatomic double-bundle anterior cruciate ligament reconstruction, using CT-based navigation and fiducial markers
Tensho K, Kodaira H, Yasuda G, Yoshimura Y, Narita N, Morioka S, Kato H, Saito N
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 19, 378–383, 2011

DJ-1 as a potential biomarker for the development of biocompatible multiwalled carbon nanotubes
Haniu H, Tsukahara T, Matsuda Y, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Takanashi S, Okamoto M, Ishigaki N, Nakamura K, Kato H, Saito N.
INTERNATIONAL JOURNAL OF NANOMEDICINE, 6(1), 2689-2695, 2011

Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines
Haniu H, Saito N, Matsuda Y, Kim YA, Park KC, Tsukahara T, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Takanashi S, Okamoto M, Ishigaki N, Nakamura K, Kato H.
INTERNATIONAL JOURNAL OF NANOMEDICINE, 6, 3487-3497, 2011

Effect of dispersants of multi-walled carbon nanotubes on cellular uptake and biological responses
Haniu H, Saito N, Matsuda Y, Kim YA, Park KC, Tsukahara T, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Takanashi S, Okamoto M, Ishigaki N, Nakamura K, Kato H.
INTERNATIONAL JOURNAL OF NANOMEDICINE, 6(1), 3295-3307, 2011

Toxicoproteomic evaluation of carbon nanomaterials in vitro
Haniu H, Matsuda Y, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Okamoto M,Takanashi S, Ishigaki N, Nakamura K, Kato H, Saito N.
JOURNAL OF PROTEOMICS, 74(12), 2703-2712, 2011

Deposition of apatite on carbon nanofibers in simulated body fluid
Taruta S, Kidokoro K, Yamakami T, Yamaguchi T, Kitajima K, Endo M, Saito N.
Journal of Nanomaterials, 935320, 1-8, 2011

Fabrication and mechanical properties of high-dispersion-treated carbon nanofiber/alumina composites
Ueda N, Yamakami T, Yamaguchi T, Kitajima K, Usui Y, Aoki K, Nakanishi T, Miyaji F, Endo M, Saito N
Journal of the Ceramic Society of Japan, 118(9), 847-854, 2010

Multi-walled carbon nanotubes specifically inhibit osteoclast differentiation and function
Narita N, Kobayashi Y, Nakamura H, Maeda K, Ishihara A, Mizoguchi T, Usui Y, Aoki K, Shimizu M, Kato H, Ozawa H, Udagawa N, Endo M, Takahashi N, Saito N
NANO LETTERS, 9(4), 1406-1413, 2009

A Thin Carbon Fiber Web as a Scaffold for Bone Tissue Regeneration
Aoki, K; Usui, Y; Narita, N; Ogiwara, N; Ishigaki, N; Nakamura, K; Kato, H; Sano, K; Ogiwara, N; Kametani, K; Kim, C; Taruta, S; Kim, YA; Endo, M; Saito, N
SMALL, 5(13), 1540-1546, 2009

Carbon nanotubes: biomaterial applications
Saito, N; Usui, Y; Aoki, K; Narita, N; Shimizu, M; Hara, K; Ogiwara, N; Nakamura, K; Ishigaki, N; Kato, H; Taruta, S; Endo, M
CHEMICAL SOCIETY REVIEWS, 38(7), 1897-1903, 2009

Carbon Nanotubes for Biomaterials in Contact with Bone
Saito, N; Usui, Y;Aoki, K; Narita, N; Shimizu, M; Ogiwara, N; Nakamura,K; Ishigaki, N; Kato, H; Taruta, S; Endo, M
Current Medicinal Chemistry, 15(5), 523-527, 2008

Carbon nanotubes with high bone-tissue compatibility and bone-formation acceleration effect
Usui, Y; Aoki, K; Narita, N; Murakami, N; Nakamura, I; Nakamura, K; Ishigaki, N; Yamazaki, H; Horiuchi, H; Kato, H; Taruta, S; Kim, YA; Endo, M; Saito, N
SMALL, 4(2), 240-246, 2008

Brothers with genu recurvatum
Saito, N; Tensyo, K; Horiuchi, H; Aoki, K; Kobayashi, S; Kato, H; Kosh, T
Knee, 14(6), 500-501, 2007

Coordinate expression of BMP-2, BMP receptors and Noggin in normal mouse spine
Nakamura Y, Nakaya H, Saito N, Wakitani S.
JOURNAL OF CLINICAL NEUROSCIENCE, 13(2), 250-256, 2006

The effects of heat on the biological activity of recombinant human bone morphogenetic protein-2
Ohta H,Wakitani S, Tensho K, Horiuchi H, Wakabayashi S, Saito N, Nakamura Y, Nozaki K, Imai Y, Takaoka K.
JOURNAL OF BONE AND MINERAL METABOLISM, 23(6), 420-425, 2005

Expression profiles of BMP-related molecules induced by BMP-2 or-4 in muscle-derived primary culture cells
Nakamura Y, Wakitani S, Saito N, Takaoka K.
JOURNAL OF BONE AND MINERAL METABOLISM, 23(6), 426-434, 2005

Use of bone morphogenetic protein 2 and diffusion chambers to engineer cartilage tissue for the repair of defects in articular cartilage
Nawata, M; Wakitani, S;Nakaya, H; Tanigami, A; Seki, T; Nakamura, Y; Saito, N; Sano, K; Hidaka, E; Takaoka, K
ARTHRITIS AND RHEUMATISM, 52(1), 155-163, 2005

Potentiation of the activity of bone morphogenetic protein-2 in bone regeneration by a PLA-PEG/hydroxyapatite composite
Kaito, T; Myoui, A; Takaoka, K; Saito, N; Nishikawa, M; Tamai, N; Ohgushi, H; Yoshikawa, H
BIOMATERIALS, 26(1), 73-79, 2005

Synthetic biodegradable polymers as drug delivery systems for bone morphogenetic proteins
Saito N, Murakami N, Takahashi J, Horiuchi H, Ota H, Kato H, Okada T, Nozaki K, Takaoka K.
ADVANCED DRUG DELIVERY REVIEWS, 57(7), 1037-1048, 2005

Total hip arthroplasty with bulk femoral head autograft for acetabular reconstruction in DDH: surgical technique
Kobayashi S, Saito N, Nawata M, Horiuchi H, Iorio R, Takaoka K.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 86 Supple 1, 11-17, 2004

Locking of the knee couasedby localized pigmented villonodular synovitis: a case report
Horiuchi H, Nawata M, Kamijo T, Saito N, Wakitani S, Kobayashi S, Shimizu T, Koto H.
MODERN RHEUMATOLOGY, 14, 184-186, 2004

Osteonecrosis of the femoral head in Japanese adults after liver transplantation: a preliminary report
Horiuchi, H; Hashikura, Y; Hisa, K; Saito, N; Ikegami, T; Nakazawa, Y; Karakida, O; Kobayashi, S; Nawata, M; Kawasaki, S; Takaoka, K
JOURNAL OF ORTHOPAEDIC SCIENCE, 9(2), 119-121, 2004

Enhancement of recombinant human bone morphogenetic protein-2 (rhBMP-2)-induced new bone formation by concurrent treatment with parathyroid hormone and a phosphodiesterase inhibitor, pentoxifylline
Horiuchi, H; Saito, N; Kinoshita, T; Wakabayashi, S; Tsutsumimoto, T; Otsuru, S; Takaoka, K
JOURNAL OF BONE AND MINERAL METABOLISM, 22(4), 329-334, 2004

Continuous local cooling for pain relief following total hip arthroplasty
Saito, N; Horiuchi, H; Kobayashi, S; Nawata, M; Takaoka, K
JOURNAL OF ARTHROPLASTY, 19(3), 334-337, 2004

Heterotopic ossification in the knee following encephalitis: a case report with a 10-year follow-up
Saito, N; Horiuchi, H; Takahashi, H
Knee, 11(1), 63-65, 2004

Extraskeletal chondroma of the hand accompanied by proliferating chondroblast-like cells with an eleven-year follow-up
Saito N, Horiuchi H, Toriumi H, Miyasaka T.
AMERICAN JOURNAL OF CASE REPORTS, 4, 66-68, 2003

Local bone formation by injection of recombinant human bone morphogenetic protein-2 contained in polymer carriers
Saito, N; Okada, T; Horiuchi, H; Ota, H; Takahashi, J; Murakami, N; Nawata, M; Kojima, S; Nozaki, K; Takaoka, K
BONE, 32(4), 381-386, 2003

Anterior Thoracic Spinal Fusion in Dogs by Injection of Recombinant Human Bone Morphogenetic Protein-2 and a Synthetic Polymer
Takahashi, J; Saito, N; Ebara, S; Kinoshita, T; Itoh, H; Okada, T; Nozaki, K; Takaoka, K
JOURNAL OF SPINAL DISORDERS&TECHNIQUES, 16(2), 137-143, 2003

Total hip arthroplasty with bulk femoral head autograft for acetabular reconstruction in developmental dysplasia of the hip
Kobayashi, S; Saito, N; Nawata, M; Horiuchi, H; Iorio, R; Takaoka, K
JOURNAL OF BONE AND JOINT SURGERY-AMERICANVOLUME, 85A(4), 615-621, 2003

Trabecular minimodeling in human iliac bone
Kobayashi, S; Takahashi, HE; Ito, A; Saito, N; Nawata, M; Horiuchi, H; Ohta, H; Ito, A; Iorio, R; Yamamoto, N; Takaoka, K
BONE, 32(2), 163-169, 2003

Osteoprotegerin regulates bone formation through a coupling mechanism with bone resorption
Nakamura, M; Udagawa, N; Matsuura, S; Mogi, M; Nakamura, H; Horiuchi, H; Saito, N; Hiraoka, BY; Kobayashi, Y; Takaoka, K; Ozawa, H; Miyazawa, H; Takahashi, N
Endocrinology, 144(12), 5441-5449, 2003

Sequential changes in periprosthetic bone mineral density following total hip arthroplasty: a 3-year follow-up
Ohta, H; Kobayashi, S; Saito, N; Nawata, M; Horiuchi, H; Takaoka, K
JOURNAL OF BONE AND MINERAL METABOLISM, 21(4), 229-233, 2003

Repair of a proximal femoral bone defect in dogs using a porous surfaced prosthesis in combination with recombinant BMP-2 and a synthetic polymer carrier
Murakami, N; Saito, N; Takahashi, J; Ota, H; Horiuchi, H; Nawata, M; Okada, T; Nozaki, K; Takaoka, K
BIOMATERIALS, 24(13), 2153-2159, 2003

New synthetic biodegradable polymers as BMP carriers for bone tissue engineering
Saito, N; Takaoka, K
BIOMATERIALS, 24(13), 2287-2293, 2003

Three-dimentional computed tomography evaluation of bony birth canal morphologic deformity (small pelvic cavity) after dome pelvic osteotomy for developmental dysplasia of the hip
Kojima S, Kobayashi S, Saito N, Nawata M, Horiuchi H, Takaoka K.
American journal of obstetrics and gynecology, 187, 1591-1595, 2002

Effect of phosphodiesterase inhibitor-4, Rolipram, on new bone formations by recombinant human bone morphogenetic protein-2
Horiuchi, H; Saito, N; Kinoshita, T; Wakabayashi, S; Yotsumoto, N; Takaoka, K
BONE, 30(4), 589-593, 2002

Repair of segmental defects in rabbit humeri with titanium fiber mesh cylinders containing recombinant human bone morphogenetic protein-2 (rhBMP-2) and a synthetic polymer
Murakami, N; Saito, N; Horiuchi, H; Okada, T; Nozaki, K; Takaoka, K
Journal of Biomedical Materials Research Part A, 62(2), 169-174, 2002

Avascular necrosis of the femoral head in a patient with Fabry's disease - Identification of ceramide trihexoside in the bone by delayed-extraction matrix-assisted laser desorption ionization-time-of-flight mass spectrometry
Horiuchi, H; Saito, N; Kobayashi, S; Ota, H; Taketomi, T; Takaoka, K
ARTHRITIS AND RHEUMATISM, 46(7), 1922-1925, 2002

Morphological characteristics of the bony birth canal in patients with developmental dysplasia of the hip (DDH): investigation by three-dimensional CT
Kojima S, Kobayashi S, Saito N, Nawata M, Horiuchi H, Takaoka K.
JOURNAL OF ORTHOPAEDIC SCIENCE, 6, 217-222, 2001

Biodegradable poly-D,L-lacticacid-polyethylene glycol block copolymers as a BMP delivery system for inducing bone
Saito, N; Okada, T; Horiuchi,H; Murakami, N; Takakashi, J; Nawata, M; Ota, H; Miyamoto, S; Nozaki, K; Takaoka, K
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 83A, S92-S98, 2001

Progressive scoliosis in cri-du-chat syndrome over a 20-year follow-up period - A case report
Saito, N; Ebara, S; Fukushima, Y; Wakui, K; Takaoka, K
SPINE, 26(7), 835-837, 2001

Enhancement of bone morphogenetic protein-2-induced new bone formation in mice by the phosphodiesterase inhibitor pentoxifylline
Horiuchi, H; Saito, N; Kinoshita, T; Wakabayashi, S; Tsutsumimoto, T; Takaoka, K
BONE, 28(3), 290-294, 2001

A biodegradable polymer as a cytokine delivery system for inducing bone formation
Saito, N; Okada,T; Horiuchi, H; Murakami, N; Takahashi, J; Nawata, M; Ota, H; Nozaki, K; Takaoka, K
NATURE BIOTECHNOLOGY, 19(4), 332-335, 2001

Poor bone quality or hip structure as risk factors affecting survival of total-hip arthroplasty
Kobayashi S, Saito N, Horiuchi H, Iorio R, Takaoka K.
Lancet, 355(9214), 1499-1504, 2000

New synthetic absorbable polymers as BMP carriers: Plastic properties of poly-D,L-lactic acid-polyethylene glycol block copolymers
Saito N, Okada T, Toba S, Miyamoto S, Takaoka K.
Journal of Biomedical Materials Research Part A, 47(1), 104-110, 1999

Natural history of scoliosis in spastic cerebral palsy
Saito N, Ebara S, Ohotsuka K, Kumeta H, Takaoka K.
Lancet, 351(9117), 1687-1692, 1998

Long-term bone remodeling around Charnley femoral prostheses: comparison of cementing techniques
Kobayashi S, Takaoka K, Saito N, Hisa K.
ARCHIVES OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS, 1, 30-33, 1997

Factors affecting aseptic failure of fixation after primary charnley totalhip arthroplasty - Multivariate survival analysis
Kobayashi S, Takaoka K, Saito N, Hisa K.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 79A(11), 1618-1627, 1997

Radiographic factors predicting non-union of displaced intracapsular femoral neck fracture
Saito N, Miyasaka T, Toriumi H.
Archives of orthopaedic and trauma surgery, 114, 183-187, 1995

Three-dimensional modeling with osteoblast-like cells under external magnetic field conditions using magnetic nano-ferrite particles for the development of cell-derived artificial bone
Ma C, Izumiya M, Nobuoka H, Ueno R, Mimura M, Ueda K, Ishida H, Tomotsune D, Johkura K, Yue F, Saito N, Haniu H
Nanomaterials, 14, 251

Advances in Medicine and Biology 11
Saito N, Aoki K, Usui Y, Shimizu M, Hara K, Narita N, Ogihara N, Nakamura K, Ishigaki N, Kato H, Haniu H, Kim C, Taruta S, Kim YA, Endo M, Thin carbon fiber web that functions as a scaffold for tissue regeneration
Nova Science Publishers, Inc., New York, 301-310 2011

Bone Regeneration: Growth Factors, Augmentation Procedures and Tissue Engineering Applications
Saito N, Usui Y, Aoki K, Narita N, Shimizu M, Hara K, Ogiwara N, Nakamura K, Ishigaki N, Kato H, Haniu H, Taruta S, Endo M, Application of carbon nanotubes on scaffolds for bone tissue regeneration
Nova Science Publishers, Inc., New York, pp 275-284 2010

New technology for bone tissue regeneration using cytokines and their drug delivery systems. In: Mashkevich BO (ed), Drug delivery research advances.
.Saito N, Murakami N, Takaoka K., Joint work
Nova Science Publishers, Inc., New York, pp 227-241 2007

New synthetic biodegradable polymers for bone morphogenetic protein delivery systems. Yaszemski MJ, Trantolo DJ, Lewandrowski KU, Hasirci V, Altobelli DE, Wise DL, eds: Tissue engineering and novel delivery systems.
Saito N, Horiuchi H, Murakami N, Takahashi J, Okada T, Nozaki K, Takaoka
Marcel Dekker inc, New York, pp 475-482 2004

New synthetic degradable polymers as carrier materials for BMP. In Wise DL(ed), Biomaterials engineering and devices: human applications, vol 1.
Takaoka K, Miyamoto S, Saito N, Okada T., Single work
The Humana Press, New Jersey, pp 239-249 2000

Bone-inducing implants: new synthetic absorbable poly-D,L-lactic acid-polyethylene glycol block copolymers as BMP-carriers. In Ikada Y, Okano T(eds), Tissue engineering for therapeutic use, vol 3.
Takaoka K, Saito N, Miyamoto S, Yoshikawa H, Okada T., Joint work
Elsevier Science B.V., Amsterdam, pp 141-151 1999

American Chemical Society