OHARA Osamu
School of Medicine Clinical Sequence
Professor
Researcher Information
Research Keyword
- Technology development of multiomics analysis, Clinical proteomics
Web site
Research activity information
Paper
- Development of a new genotype–phenotype linked antibody screening system
Takashi Watanabe; Hikaru Hata; Yoshiki Mochizuki; Fumie Yokoyama; Tomoko Hasegawa; Naveen Kumar; Tomohiro Kurosaki; Osamu Ohara; Hidehiro Fukuyama
Oct. 2024
Lead
- Low remission rates and high incidence of adverse events in a prospective VEXAS syndrome registry.
Yohei Kirino; Ayaka Maeda; Tomoyuki Asano; Kiyoshi Migita; Yukiko Hidaka; Hiroaki Ida; Daisuke Kobayashi; Nobuhiro Oda; Ryo Rokutanda; Yuichiro Fujieda; Tatsuya Atsumi; Dai Kishida; Hiroshi Kobayashi; Motoaki Shiratsuchi; Toshimasa Shimizu; Atsushi Kawakami; Kazuki Tanaka; Tomohiro Tsuji; Koji Mishima; Takako Miyamae; Anna Hasegawa; Kei Ikeda; Tomoya Watanabe; Yukie Yamaguchi; Ryuta Nishikomori; Osamu Ohara; Hideaki Nakajima
Rheumatology (Oxford, England), Sep. 2024
Lead - Platelet changes and bleeding symptoms in children, adolescents, and adults with 22q11.2 deletion syndrome.
Atsushi Sakamoto; Toru Uchiyama; Ryohei Futatsugi; Osamu Ohara; Akihiro Iguchi; Tadashi Kaname; Makoto Hikosaka; Hiroshi Ono; Shinji Kunishima; Shuichi Ito; Akira Ishiguro
Pediatric blood & cancer, e31292, Sep. 2024
Lead - Host-derived protein profiles of human neonatal meconium across gestational ages.
Yoshihiko Shitara; Ryo Konno; Masahito Yoshihara; Kohei Kashima; Atsushi Ito; Takeo Mukai; Goh Kimoto; Satsuki Kakiuchi; Masaki Ishikawa; Tomo Kakihara; Takeshi Nagamatsu; Naoto Takahashi; Jun Fujishiro; Eiryo Kawakami; Osamu Ohara; Yusuke Kawashima; Eiichiro Watanabe
Nature communications, 15(1), 5543-5543, Jul. 2024
Lead - Heart failure promotes multimorbidity through innate immune memory.
Yukiteru Nakayama; Katsuhito Fujiu; Tsukasa Oshima; Jun Matsuda; Junichi Sugita; Takumi James Matsubara; Yuxiang Liu; Kohsaku Goto; Kunihiro Kani; Ryoko Uchida; Norifumi Takeda; Hiroyuki Morita; Yingda Xiao; Michiko Hayashi; Yujin Maru; Eriko Hasumi; Toshiya Kojima; Soh Ishiguro; Yusuke Kijima; Nozomu Yachie; Satoshi Yamazaki; Ryo Yamamoto; Fujimi Kudo; Mio Nakanishi; Atsushi Iwama; Ryoji Fujiki; Atsushi Kaneda; Osamu Ohara; Ryozo Nagai; Ichiro Manabe; Issei Komuro
Science immunology, 9(95), eade3814, May 2024
Lead - The integration of metabolic and proteomic data uncovers an augmentation of the sphingolipid biosynthesis pathway during T-cell differentiation.
Toshio Kanno; Ryo Konno; Masaru Sato; Atsushi Kurabayashi; Keisuke Miyako; Takahiro Nakajima; Satoru Yokoyama; Shigemi Sasamoto; Hikari K Asou; Junichiro Ohzeki; Yoshinori Hasegawa; Kazutaka Ikeda; Yusuke Kawashima; Osamu Ohara; Yusuke Endo
Communications biology, 7(1), 622-622, May 2024
Lead - Integrated proteogenomic analysis for inherited bone marrow failure syndrome.
Manabu Wakamatsu; Hideki Muramatsu; Hironori Sato; Masaki Ishikawa; Ryo Konno; Daisuke Nakajima; Motoharu Hamada; Yusuke Okuno; Yusuke Kawashima; Asahito Hama; Masafumi Ito; Hideto Iwafuchi; Yoshiyuki Takahashi; Osamu Ohara
Leukemia, May 2024
Lead - Ultra-deep proteomics by Thin-diaPASEF with a 60-cm long column system
Ryo Konno; Masaki Ishikawa; Daisuke Nakajima; Sho Hagiwara; Kaori Inukai; Osamu Ohara; Yusuke Kawashima
Apr. 2024
Lead - Diagnostic delay of MYH9-related disorder in Japan.
Atsushi Sakamoto; Toru Uchiyama; Tadashi Kaname; Akihiro Iguchi; Osamu Ohara; Masataka Ishimura; Masaei Onum; Shinji Kunishima; Akira Ishiguro
British journal of haematology, Apr. 2024
Lead - 網羅的タンパク質解析技術を用いた胎便タンパク質解析研究
渡辺 栄一郎; 設樂 佳彦; 紺野 亮; 吉原 正仁; 柿原 知; 高橋 尚人; 藤代 準; 川上 英良; 小原 收; 川島 祐介
日本小児外科学会雑誌, 60(2), 209-210, Apr. 2024
Lead - 便プロテオーム解析を用いた胆道閉鎖症・葛西術後の肝病態に関する研究
渡辺 栄一郎; 斎藤 傑; 紺野 亮; 高澤 慎也; 一瀬 諒紀; 三宅 和恵; 柿原 知; 石川 将己; 石丸 哲也; 西 明; 福田 晃也; 笠原 群生; 小原 收; 川島 祐介; 藤代 準
日本小児外科学会雑誌, 60(3), 390-390, Apr. 2024
Lead - 短腸症候群患児に特異的な便中ヒト由来タンパク質の同定と機能解析
高澤 慎也; 渡辺 栄一郎; 川島 祐介; 紺野 亮; 石川 将己; 柿原 知; 吉田 真理子; 森田 香織; 柳田 佳嗣; 一瀬 諒紀; 松田 理奈; 西 明; 小原 收; 藤代 準
日本小児外科学会雑誌, 60(3), 478-478, Apr. 2024
Lead - 網羅的タンパク質解析技術を用いた胎便タンパク質解析研究
渡辺 栄一郎; 設樂 佳彦; 紺野 亮; 吉原 正仁; 柿原 知; 高橋 尚人; 藤代 準; 川上 英良; 小原 收; 川島 祐介
日本小児外科学会雑誌, 60(2), 209-210, Apr. 2024
Lead - Dataset for proteome analysis of K562 cell tryptic peptides dissolved by solutions with 12 surfactants
Masaki Ishikawa; Ryo Konno; Daisuke Nakajima; Yusuke Endo; Osamu Ohara; Yusuke Kawashima
Journal of Proteome Data and Methods Online ISSN : 2434-6454, 6, 2, Apr. 2024, Refereed
Lead - Dataset for proteome analysis by InSpIon system capable of stable nanoESI spray
Masaki Ishikawa; Ryo Konno; Daisuke Nakajima; Osamu Ohara; Yusuke Kawashima
Journal of Proteome Data and Methods, 6, 1, Apr. 2024, Refereed
Lead - Effects of Anti-Fibrotic Drugs on Transcriptome of Peripheral Blood Mononuclear Cells in Idiopathic Pulmonary Fibrosis
Daisuke Ishii; Takeshi Kawasaki; Hironori Sato; Koichiro Tatsumi; Takuro Imamoto; Keiichiro Yoshioka; Mitsuhiro Abe; Yoshinori Hasegawa; Osamu Ohara; Takuji Suzuki
International Journal of Molecular Sciences, 25(7), Mar. 2024
Lead - Transcriptome Analysis of Peripheral Blood Mononuclear Cells in Chronic Obstructive Pulmonary Disease(タイトル和訳中)
Imamoto Takuro; Kawasaki Takeshi; Sato Hironori; Ishii Daisuke; Yoshioka Keiichiro; Hasegawa Yoshinori; Ohara Osamu; Tatsumi Koichiro; Suzuki Takuji
日本呼吸器学会誌, 13(増刊), 386-386, Mar. 2024
Lead - Clinical characteristics of cryopyrin-associated periodic syndrome and long-term real-world efficacy and tolerability of canakinumab in Japan: results of a nationwide survey.
Takayuki Miyamoto; Kazushi Izawa; Sho Masui; Atsue Yamazaki; Yuichi Yamasaki; Tadashi Matsubayashi; Mayuka Shiraki; Hidenori Ohnishi; Junko Yasumura; Kawabe Tomohiro; Takako Miyamae; Tomoyo Matsubara; Naoya Arakawa; Takashi Ishige; Takumi Takizawa; Asami Shimbo; Masaki Shimizu; Naoki Kimura; Yuichi Maeda; Yuta Maruyama; Tomonari Shigemura; Junichi Furuta; Satoshi Sato; Hiroshi Tanaka; Miharu Izumikawa; Masahiro Yamamura; Toshio Hasegawa; Hiroshi Kaneko; Yasuo Nakagishi; Naoko Nakano; Yasunori Iida; Tamaki Nakamura; Hiroyuki Wakiguchi; Takayuki Hoshina; Toshinao Kawai; Kosaku Murakami; Shuji Akizuki; Akio Morinobu; Koichiro Ohmura; Katsuhide Eguchi; Motoshi Sonoda; Masataka Ishimura; Kenji Furuno; Momoko Kashiwado; Masaaki Mori; Kimito Kawahata; Koremasa Hayama; Kumiko Shimoyama; Natsuko Sasaki; Taisuke Ito; Hiroaki Umebayashi; Tae Omori; Seiko Nakamichi; Tomotsune Dohmoto; Yasuyuki Hasegawa; Hisashi Kawashima; Shojiro Watanabe; Yuichiro Taguchi; Haruna Nakaseko; Naomi Iwata; Hiroki Kohno; Taiki Ando; Yasuhiko Ito; Yuko Kataoka; Takako Saeki; Utako Kaneko; Ayako Murase; Seira Hattori; Tomo Nozawa; Kenichi Nishimura; Reiji Nakano; Misa Watanabe; Masato Yashiro; Tomonori Nakamura; Toshihiko Komai; Kentaro Kato; Yoshitaka Honda; Eitaro Hiejima; Atsushi Yonezawa; Kazuhisa Bessho; Satoshi Okada; Osamu Ohara; Junko Takita; Takahiro Yasumi; Ryuta Nishikomori
Arthritis & rheumatology (Hoboken, N.J.), Jan. 2024
Lead - Proteome Analysis of Serum Purified Using Solanum tuberosum and Lycopersicon esculentum Lectins
Daisuke Nakajima; Ryo Konno; Yasuomi Miyashita; Masaki Ishikawa; Osamu Ohara; Yusuke Kawashima
International Journal of Molecular Sciences, Jan. 2024
Lead - Functional Roles of CD26/DPP4 in Bleomycin-Induced Pulmonary Hypertension Associated with Interstitial Lung Disease
Tadasu Okaya; Takeshi Kawasaki; Shun Sato; Yu Koyanagi; Koichiro Tatsumi; Ryo Hatano; Kei Ohnuma; Chikao Morimoto; Yoshitoshi Kasuya; Yoshinori Hasegawa; Osamu Ohara; Takuji Suzuki
International Journal of Molecular Sciences, Jan. 2024
Lead - Characterization of metabolic phenotypes and distinctive genes in mice with low-weight gain.
Shino Nemoto; Tetsuya Kubota; Tomoyuki Ishikura; Manabu Nakayama; Atsuo Kobayashi; Junshi Yazaki; Kazuyo Uchida; Masashi Matsuda; Takashi Kondo; Osamu Ohara; Haruhiko Koseki; Shigeo Koyasu; Hiroshi Ohno
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 38(1), e23339, Jan. 2024
Lead - Different Transcriptome Features of Peripheral Blood Mononuclear Cells in Non-Emphysematous Chronic Obstructive Pulmonary Disease
Takuro Imamoto; Takeshi Kawasaki; Hironori Sato; Koichiro Tatsumi; Daisuke Ishii; Keiichiro Yoshioka; Yoshinori Hasegawa; Osamu Ohara; Takuji Suzuki
International Journal of Molecular Sciences, Dec. 2023
Lead - ACC1-mediated fatty acid biosynthesis intrinsically controls thymic iNKT cell development.
Toshio Kanno; Keisuke Miyako; Takeru Endo; Satoru Yokoyama; Hikari K Asou; Kazuko Yamada; Osamu Ohara; Toshinori Nakayama; Motoko Y Kimura; Yusuke Endo
International immunology, Dec. 2023
Lead - Exome-wide benchmark of difficult-to-sequence regions using short-read next-generation dna sequencing.
Atsushi Hijikata; Mikita Suyama; Shingo Kikugawa; Ryo Matoba; Takuya Naruto; Yumi Enomoto; Kenji Kurosawa; Naoki Harada; Kumiko Yanagi; Tadashi Kaname; Keisuke Miyako; Masaki Takazawa; Hideo Sasai; Junichi Hosokawa; Sakae Itoga; Tomomi Yamaguchi; Tomoki Kosho; Keiko Matsubara; Yoko Kuroki; Maki Fukami; Kaori Adachi; Eiji Nanba; Naomi Tsuchida; Yuri Uchiyama; Naomichi Matsumoto; Kunihiro Nishimura; Osamu Ohara
Nucleic acids research, Nov. 2023
Lead - Janus kinase inhibitors ameliorate clinical symptoms in patients with STAT3 gain-of-function
Shuya Kaneko; Fumiaki Sakura; Kay Tanita; Asami Shimbo; Ryusuke Nambu; Masashi Yoshida; Shuichiro Umetsu; Ayano Inui; Chizuru Okada; Miyuki Tsumura; Mamiko Yamada; Hisato Suzuki; Kenjiro Kosaki; Osamu Ohara; Masaki Shimizu; Tomohiro Morio; Satoshi Okada; Hirokazu Kanegane
Immunotherapy Advances, 3(1), ltad027, Nov. 2023
Lead - A MinION-Based Long-Read Sequencing Application with One-Step PCR for the Genetic Diagnosis of 21-Hydroxylase Deficiency.
Eriko Adachi; Ryuichi Nakagawa; Atsumi Tsuji-Hosokawa; Maki Gau; Shizuka Kirino; Analia Yogi; Hisae Nakatani; Kei Takasawa; Tomomi Yamaguchi; Tomoki Kosho; Masanori Murakami; Toshihiro Tajima; Tomonobu Hasegawa; Tetsuya Yamada; Tomohiro Morio; Osamu Ohara; Kenichi Kashimada
The Journal of clinical endocrinology and metabolism, Oct. 2023
Lead - Multifaceted analysis of cross-tissue transcriptomes reveals phenotype–endotype associations in atopic dermatitis
Aiko Sekita; Hiroshi Kawasaki; Ayano Fukushima-Nomura; Kiyoshi Yashiro; Keiji Tanese; Susumu Toshima; Koichi Ashizaki; Tomohiro Miyai; Junshi Yazaki; Atsuo Kobayashi; Shinichi Namba; Tatsuhiko Naito; Qingbo S. Wang; Eiryo Kawakami; Jun Seita; Osamu Ohara; Kazuhiro Sakurada; Yukinori Okada; Masayuki Amagai; Haruhiko Koseki
Nature Communications, 14(1), Oct. 2023
Lead - Time-dependent cell-state selection identifies transiently expressed genes regulating ILC2 activation.
Yumiko Tanaka; Mai Yamagishi; Yasutaka Motomura; Takashi Kamatani; Yusuke Oguchi; Nobutake Suzuki; Tsuyoshi Kiniwa; Hiroki Kabata; Misato Irie; Tatsuhiko Tsunoda; Fuyuki Miya; Keisuke Goda; Osamu Ohara; Takashi Funatsu; Koichi Fukunaga; Kazuyo Moro; Sotaro Uemura; Yoshitaka Shirasaki
Communications biology, 6(1), 915-915, Sep. 2023
Lead - Gut microbial carbohydrate metabolism contributes to insulin resistance.
Tadashi Takeuchi; Tetsuya Kubota; Yumiko Nakanishi; Hiroshi Tsugawa; Wataru Suda; Andrew Tae-Jun Kwon; Junshi Yazaki; Kazutaka Ikeda; Shino Nemoto; Yoshiki Mochizuki; Toshimori Kitami; Katsuyuki Yugi; Yoshiko Mizuno; Nobutake Yamamichi; Tsutomu Yamazaki; Iseki Takamoto; Naoto Kubota; Takashi Kadowaki; Erik Arner; Piero Carninci; Osamu Ohara; Makoto Arita; Masahira Hattori; Shigeo Koyasu; Hiroshi Ohno
Nature, 621(7978), 389-395, Sep. 2023
Lead - Universal pretreatment development for low-input proteomics using Lauryl Maltose Neopentyl Glycol
Ryo Konno; Masaki Ishikawa; Daisuke Nakajima; Yusuke Endo; Osamu Ohara; Yusuke Kawashima
Molecular & cellular proteomics : MCP, 23(4), 100745-100745, Aug. 2023
Lead - 1-Oleoyl-lysophosphatidylethanolamine stimulates RORγt activity in T H 17 cells
Yusuke Endo; Toshio Kanno; Takahiro Nakajima; Kazutaka Ikeda; Yoshitaka Taketomi; Satoru Yokoyama; Shigemi Sasamoto; Hikari K. Asou; Keisuke Miyako; Yoshinori Hasegawa; Yusuke Kawashima; Osamu Ohara; Makoto Murakami; Toshinori Nakayama
Science Immunology, 8(86), Aug. 2023
Lead - Isolated chronic mucocutaneous candidiasis due to a novel duplication variant of IL17RC.
Kosuke Noma; Miyuki Tsumura; Tina Nguyen; Takaki Asano; Fumiaki Sakura; Moe Tamaura; Yusuke Imanaka; Yoko Mizoguchi; Shuhei Karakawa; Seiichi Hayakawa; Takayo Shoji; Junichi Hosokawa; Kazushi Izawa; Yun Ling; Jean-Laurent Casanova; Anne Puel; Stuart G Tangye; Cindy S Ma; Osamu Ohara; Satoshi Okada
Research square, Aug. 2023
Lead - Inherited macrothrombocytopenia due to a novel splice donor site mutation in ITGB3.
Yukiko Komeno; Toru Uchiyama; Fuyuko Kawano; Yuya Kurihara; Mineo Kurokawa; Osamu Ohara; Shinji Kunishima; Akira Ishiguro
Annals of hematology, Jul. 2023
Lead - TAp63, a methotrexate target in CD4+ T cells, suppresses Foxp3 expression and exacerbates autoimmune arthritis
Kensuke Suga; Akira Suto; Shigeru Tanaka; Yutaka Sugawara; Takahiro Kageyama; Junichi Ishikawa; Yoshie Sanayama; Kei Ikeda; Shunsuke Furuta; Shin-Ichiro Kagami; Arifumi Iwata; Koichi Hirose; Kotaro Suzuki; Osamu Ohara; Hiroshi Nakajima
JCI Insight, 8(10), May 2023
Lead - 活性化CD4T細胞サブセットでの細胞内代謝経路に着目をした網羅的なオミックス解析の研究
菅野 敏生; 中嶋 隆裕; 池田 和貴; 佐藤 大; 長谷川 嘉則; 川島 祐介; 小原 收; 遠藤 裕介
脂質生化学研究, 65, 230-231, May 2023
Lead - In-depth proteomic analysis of juvenile dermatomyositis serum reveals protein expression associated with muscle-specific autoantibodies.
Hironori Sato; Yuzaburo Inoue; Yusuke Kawashima; Ryo Konno; Osamu Ohara; Masataka Kuwana; Norimoto Kobayashi; Shunichiro Takezaki; Shinji Akioka
Rheumatology (Oxford, England), Apr. 2023
Lead - Development of a Simple and Stable NanoESI Spray System Using Suction Wind from the MS Inlet.
Yusuke Kawashima; Masaki Ishikawa; Ryo Konno; Daisuke Nakajima; Osamu Ohara
Journal of proteome research, 22(5), 1564-1569, Apr. 2023
Lead - A complementary approach for genetic diagnosis of inborn errors of immunity using proteogenomic analysis.
Fumiaki Sakura; Kosuke Noma; Takaki Asano; Kay Tanita; Etsushi Toyofuku; Kentaro Kato; Miyuki Tsumura; Hiroshi Nihira; Kazushi Izawa; Kanako Mitsui-Sekinaka; Ryo Konno; Yusuke Kawashima; Yoko Mizoguchi; Shuhei Karakawa; Seiichi Hayakawa; Hiroshi Kawaguchi; Kohsuke Imai; Shigeaki Nonoyama; Takahiro Yasumi; Hidenori Ohnishi; Hirokazu Kanegane; Osamu Ohara; Satoshi Okada
PNAS nexus, 2(4), pgad104, Apr. 2023
Lead - Desmoglein-specific B-cell-targeted single-cell analysis revealing unique gene regulation in pemphigus patients.
Shohei Egami; Takashi Watanabe; Ayano Fukushima-Nomura; Hisashi Nomura; Hayato Takahashi; Jun Yamagami; Osamu Ohara; Masayuki Amagai
The Journal of investigative dermatology, Mar. 2023
Lead - 肺サルコイドーシスにおける末梢血単核球のトランスクリプトーム解析(Transcriptome Analysis of Peripheral Blood Mononuclear Cells in Pulmonary Sarcoidosis)
Kawasaki Takeshi; Yoshioka Keiichiro; Sato Hironori; Ishii Daisuke; Imamoto Takuro; Abe Mitsuhiro; Hasegawa Yoshinori; Ohara Osamu; Tatsumi Koichiro; Suzuki Takuji
日本呼吸器学会誌, 12(増刊), 370-370, Mar. 2023
Lead - Transcriptome Analysis of Peripheral Blood Mononuclear Cells in Pulmonary Sarcoidosis(タイトル和訳中)
Kawasaki Takeshi; Yoshioka Keiichiro; Sato Hironori; Ishii Daisuke; Imamoto Takuro; Abe Mitsuhiro; Hasegawa Yoshinori; Ohara Osamu; Tatsumi Koichiro; Suzuki Takuji
日本呼吸器学会誌, 12(増刊), 370-370, Mar. 2023
Lead - 肺血管内皮細胞の炎症応答におけるCD26/DPP4の役割(アンコール演題)
高橋 由希子; 川崎 剛; 佐藤 裕範; 長谷川 嘉則; Dudek Steven M.; 小原 收; 巽 浩一郎; 鈴木 拓児
日本呼吸器学会誌, 12(増刊), 358-358, Mar. 2023
Lead - Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice.
Takafumi Namiki; Jumpei Terakawa; Harumi Karakama; Michiko Noguchi; Hironobu Murakami; Yoshinori Hasegawa; Osamu Ohara; Takiko Daikoku; Junya Ito; Naomi Kashiwazaki
Scientific reports, 13(1), 854-854, Jan. 2023
Lead - Dataset for proteogenomic signature analysis of differentiation of CD4+ T cell subsets.
Ryo Konno; Toshio Kanno; Osamu Ohara; Yusuke Endo; Yusuke Kawashima
Journal of Proteome Data and Methods, 2023, Refereed
Lead - Dataset for high-throughput proteomics by DIA using Q-Orbitrap mass spectrometer and 5-min gradient LC
Masaki Ishikawa; Ryo Konno; Daisuke Nakajima; Osamu Ohara; Yusuke Kawashima
Journal of Proteome Data and Methods, 2023, Refereed
Lead - Dataset for proteome analysis of dried blood spot by DIA-MS
Daisuke Nakajima; Yusuke Kawashima; Osamu Ohara
Journal of Proteome Data and Methods, 2023, Refereed
Lead - Characterization of proteogenomic signatures of differentiation of CD4 + T cell subsets.
Toshio Kanno; Ryo Konno; Keisuke Miyako; Takahiro Nakajima; Satoru Yokoyama; Shigemi Sasamoto; Hikari K Asou; Junichiro Ohzeki; Yusuke Kawashima; Yoshinori Hasegawa; Osamu Ohara; Yusuke Endo
DNA research : an international journal for rapid publication of reports on genes and genomes, 30(1), Dec. 2022
Lead - Bile Proteome Analysis by High-Precision Mass Spectrometry to Examine Novel Biomarkers of Primary Sclerosing Cholangitis.
Motoyasu Kan; Tetsuhiro Chiba; Ryo Konno; Yusuke Kouchi; Takashi Mishima; Yusuke Kawashima; Takashi Kishimoto; Masayuki Ohtsuka; Osamu Ohara; Naoya Kato
Journal of hepato-biliary-pancreatic sciences, Dec. 2022
Lead - PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment
Junichiro Takano; Shinsuke Ito; Yixing Dong; Jafar Sharif; Yaeko Nakajima-Takagi; Taichi Umeyama; Yong-Woon Han; Kyoichi Isono; Takashi Kondo; Yusuke Iizuka; Tomohiro Miyai; Yoko Koseki; Mika Ikegaya; Mizuki Sakihara; Manabu Nakayama; Osamu Ohara; Yoshinori Hasegawa; Kosuke Hashimoto; Erik Arner; Robert J. Klose; Atsushi Iwama; Haruhiko Koseki; Tomokatsu Ikawa
Nature Communications, 13(1), 7159-7159, Nov. 2022, Refereed, Not invited
Lead - Proteogenomic landscape and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors.
Azusa Yamato; Hidekazu Nagano; Yue Gao; Tatsuma Matsuda; Naoko Hashimoto; Akitoshi Nakayama; Kazuyuki Yamagata; Masataka Yokoyama; Yingbo Gong; Xiaoyan Shi; Siti Nurul Zhahara; Takashi Kono; Yuki Taki; Naoto Furuki; Motoi Nishimura; Kentaro Horiguchi; Yasuo Iwadate; Masaki Fukuyo; Bahityar Rahmutulla; Atsushi Kaneda; Yoshinori Hasegawa; Yusuke Kawashima; Osamu Ohara; Tetsuo Ishikawa; Eiryo Kawakami; Yasuhiro Nakamura; Naoko Inoshita; Shozo Yamada; Noriaki Fukuhara; Hiroshi Nishioka; Tomoaki Tanaka
Communications biology, 5(1), 1304-1304, Nov. 2022
Lead - Clinical and Genetic Characterization of Patients with Artemis Deficiency in Japan.
Kento Inoue; Satoshi Miyamoto; Dan Tomomasa; Eriko Adachi; Shohei Azumi; Yasuo Horikoshi; Takashi Ishihara; Shinya Osone; Yuta Kawahara; Ko Kudo; Zenichiro Kato; Hidenori Ohnishi; Kenichi Kashimada; Kohsuke Imai; Osamu Ohara; Menno C van Zelm; Morton J Cowan; Tomohiro Morio; Hirokazu Kanegane
Journal of clinical immunology, 43(3), 585-594, Nov. 2022
Lead - Dataset for deep single-shot proteomics by DIA with FAIMS
Yusuke Kawashima; Masaki Ishikawa; Ryo Konno; Daisuke Nakajima; Osamu Ohara
Journal of Proteome Data and Methods, 4, 4, Nov. 2022, Refereed
Lead - 高深度DIA-MSを用いた若年性皮膚筋炎の血清タンパクプロファイル
佐藤 裕範; 井上 祐三朗; 川島 祐介; 小原 收; 小林 法元; 竹崎 俊一郎; 秋岡 親司
日本小児リウマチ学会総会・学術集会プログラム・抄録集, 31回, 156-156, Oct. 2022
Lead - Identification of trypsin-degrading commensals in the large intestine.
Youxian Li; Eiichiro Watanabe; Yusuke Kawashima; Damian R Plichta; Zhujun Wang; Makoto Ujike; Qi Yan Ang; Runrun Wu; Munehiro Furuichi; Kozue Takeshita; Koji Yoshida; Keita Nishiyama; Sean M Kearney; Wataru Suda; Masahira Hattori; Satoshi Sasajima; Takahiro Matsunaga; Xiaoxi Zhang; Kazuto Watanabe; Jun Fujishiro; Jason M Norman; Bernat Olle; Shutoku Matsuyama; Ho Namkoong; Yoshifumi Uwamino; Makoto Ishii; Koichi Fukunaga; Naoki Hasegawa; Osamu Ohara; Ramnik J Xavier; Koji Atarashi; Kenya Honda
Nature, 609(7927), 582-589, Sep. 2022
Lead - マウス胚着床前後の子宮内膜におけるLIF受容体の局在変化とその機能解析
並木 貴文; 唐釜 春実; 中村 さくら; 大友 茉奈; 須山 あゆみ; 寺川 純平; 大黒 多希子; 影山 敦子; 長谷川 嘉則; 小原 収; 伊藤 潤哉; 柏崎 直巳
日本生殖内分泌学会雑誌, 27, 10-13, Sep. 2022
Lead - SCD2-mediated cooperative activation of IRF3-IRF9 regulatory circuit controls type I interferon transcriptome in CD4+ T cells
Toshio Kanno; Keisuke Miyako; Takahiro Nakajima; Satoru Yokoyama; Shigemi Sasamoto; Hikari K. Asou; Osamu Ohara; Toshinori Nakayama; Yusuke Endo
Frontiers in Immunology, 13, Aug. 2022
Lead - Optimization of Ultrafast Proteomics Using an LC-Quadrupole-Orbitrap Mass Spectrometer with Data-Independent Acquisition.
Masaki Ishikawa; Ryo Konno; Daisuke Nakajima; Mari Gotoh; Keiko Fukasawa; Hironori Sato; Ren Nakamura; Osamu Ohara; Yusuke Kawashima
Journal of proteome research, 21(9), 2085-2093, Aug. 2022
Lead - Trapping of CDC42 C-terminal variants in the Golgi drives pyrin inflammasome hyperactivation.
Masahiko Nishitani-Isa; Kojiro Mukai; Yoshitaka Honda; Hiroshi Nihira; Takayuki Tanaka; Hirofumi Shibata; Kumi Kodama; Eitaro Hiejima; Kazushi Izawa; Yuri Kawasaki; Mitsujiro Osawa; Yu Katata; Sachiko Onodera; Tatsuya Watanabe; Takashi Uchida; Shigeo Kure; Junko Takita; Osamu Ohara; Megumu K Saito; Ryuta Nishikomori; Tomohiko Taguchi; Yoji Sasahara; Takahiro Yasumi
The Journal of experimental medicine, 219(6), Jun. 2022
Lead - プロテオーム解析を用いた腸液再注入法の意義に関する研究
柿原 知; 渡辺 栄一郎; 三宅 和恵; 高澤 慎也; 吉田 真理子; 紺野 亮; 川島 祐介; 小原 収; 藤代 準
日本小児外科学会雑誌, 58(4), 774-774, Jun. 2022
Lead - Single-Shot 10K Proteome Approach: Over 10,000 Protein Identifications by Data-Independent Acquisition-Based Single-Shot Proteomics with Ion Mobility Spectrometry.
Yusuke Kawashima; Hirotaka Nagai; Ryo Konno; Masaki Ishikawa; Daisuke Nakajima; Hironori Sato; Ren Nakamura; Tomoyuki Furuyashiki; Osamu Ohara
Journal of proteome research, 21(6), 1418-1427, May 2022
Lead - Evaluation of the Suitability of Dried Saliva Spots for In-Depth Proteome Analyses for Clinical Applications
Hironori Sato; Daisuke Nakajima; Masaki Ishikawa; Ryo Konno; Ren Nakamura; Osamu Ohara; Yusuke Kawashima
Journal of Proteome Research, Apr. 2022
Lead - 先天性腎盂尿管移行部通過障害に対する尿プロテオーム解析の試み
藤代 準; 渡辺 栄一郎; 紺野 亮; 川島 祐介; 高澤 慎也; 吉田 真理子; 小原 收
日本小児外科学会雑誌, 58(3), 473-473, Apr. 2022
Lead - マウス胚着床前後の子宮内膜におけるLIF受容体の局在変化とその機能解析
並木 貴文; 唐釜 春実; 中村 さくら; 大友 茉奈; 須山 あゆみ; 寺川 純平; 大黒 多希子; 影山 敦子; 長谷川 嘉則; 小原 収; 伊藤 潤哉; 柏崎 直巳
日本内分泌学会雑誌, 97(5), 1360-1360, Mar. 2022
Lead - In-Depth Serum Proteomics by DIA-MS with In Silico Spectral Libraries Reveals Dynamics during the Active Phase of Systemic Juvenile Idiopathic Arthritis
Hironori Sato; Yuzaburo Inoue; Yusuke Kawashima; Daisuke Nakajima; Masaki Ishikawa; Ryo Konno; Ren Nakamura; Daigo Kato; Kanako Mitsunaga; Takeshi Yamamoto; Akiko Yamaide; Minako Tomiita; Akira Hoshioka; Osamu Ohara; Naoki Shimojo
ACS Omega, Feb. 2022
Lead - Establishment of mouse stem cells that can recapitulate the developmental potential of primitive endoderm.
Yasuhide Ohinata; Takaho A Endo; Hiroki Sugishita; Takashi Watanabe; Yusuke Iizuka; Yurie Kawamoto; Atsunori Saraya; Mami Kumon; Yoko Koseki; Takashi Kondo; Osamu Ohara; Haruhiko Koseki
Science (New York, N.Y.), 375(6580), 574-578, Feb. 2022
Lead - 便を用いた非侵襲的胆道閉鎖症診断法の開発
高見 尚平; 柿原 知; 渡辺 栄一郎; 川島 祐介; 小原 收; 金井 克晃; 藤代 準
日本小児外科学会雑誌, 58(1), 119-119, Feb. 2022
Lead - IgM to IgG Class Switching Is a Necessary Step for Pemphigus Phenotype Induction in Desmoglein 3-Specific B Cell Receptor Knock-in Mouse.
Hisashi Nomura; Naoko Wada; Hayato Takahashi; Yuko Kase; Jun Yamagami; Shohei Egami; Hisato Iriki; Miho Mukai; Aki Kamata; Hiromi Ito; Hideki Fujii; Tomoyuki Ishikura; Haruhiko Koseki; Takashi Watanabe; Taketo Yamada; Osamu Ohara; Shigeo Koyasu; Masayuki Amagai
Journal of immunology (Baltimore, Md. : 1950), 208(3), 582-593, Feb. 2022
Lead - Assessment of type I interferon signatures in undifferentiated inflammatory diseases: A Japanese multicenter experience.
Takayuki Miyamoto; Yoshitaka Honda; Kazushi Izawa; Nobuo Kanazawa; Saori Kadowaki; Hidenori Ohnishi; Masakazu Fujimoto; Naotomo Kambe; Naoya Kase; Takeshi Shiba; Yasuo Nakagishi; Shuji Akizuki; Kosaku Murakami; Masahiro Bamba; Yutaka Nishida; Ayano Inui; Tomoo Fujisawa; Daisuke Nishida; Naomi Iwata; Yoshikazu Otsubo; Shingo Ishimori; Momoko Nishikori; Kiminobu Tanizawa; Tomoyuki Nakamura; Takeshi Ueda; Yoko Ohwada; Yu Tsuyusaki; Masaki Shimizu; Takasuke Ebato; Kousho Iwao; Akiharu Kubo; Toshinao Kawai; Tadashi Matsubayashi; Tatsuhiko Miyazaki; Tomohiro Kanayama; Masahiko Nishitani-Isa; Hiroshi Nihira; Junya Abe; Takayuki Tanaka; Eitaro Hiejima; Satoshi Okada; Osamu Ohara; Megumu K Saito; Junko Takita; Ryuta Nishikomori; Takahiro Yasumi
Frontiers in immunology, 13, 905960-905960, 2022
Lead - Role of Scl39a13/ZIP13 in cardiovascular homeostasis.
Takafumi Hara; Ikuko Yamada; Takuto Ohashi; Masaru Tamura; Atsushi Hijikata; Takashi Watanabe; Minghao Gao; Kana Ito; Saeko Kawamata; Shiori Azuma; Emi Yoshigai; Yukiko Sumiyoshi; Natsumi Yasuhiro; Osamu Ohara; Heloísa G Dos Santos; Toshiyuki Fukada
PloS one, 17(10), e0276452, 2022
Lead - Neutralizing Type I Interferon Autoantibodies in Japanese Patients with Severe COVID-19
Eto, Shohei; Nukui, Yoko; Tsumura, Miyuki; Nakagama, Yu; Kashimada, Kenichi; Mizoguchi, Yoko; Utsumi, Takanori; Taniguchi, Maki; Sakura, Fumiaki; Noma, Kosuke; Yoshida, Yusuke; Ohshimo, Shinichiro; Nagashima, Shintaro; Okamoto, Keisuke; Endo, Akifumi; Imai, Kohsuke; Kanegane, Hirokazu; Ohnishi, Hidenori; Hirata, Shintaro; Sugiyama, Eiji; Shime, Nobuaki; Ito, Masanori; Ohge, Hiroki; Kido, Yasutoshi; Bastard, Paul; Casanova, Jean-Laurent; Ohara, Osamu; Tanaka, Junko; Morio, Tomohiro; Okada, Satoshi
Journal of Clinical Immunology, 2022
Lead
- Transcriptome Analysis of Peripheral Blood Mononuclear Cells in Pulmonary Sarcoidosis.
Keiichiro Yoshioka; Hironori Sato; Takeshi Kawasaki; Daisuke Ishii; Takuro Imamoto; Mitsuhiro Abe; Yoshinori Hasegawa; Osamu Ohara; Koichiro Tatsumi; Takuji Suzuki
Frontiers in medicine, 9, 822094-822094, 2022
Lead - Data-Independent Acquisition Mass Spectrometry-Based Deep Proteome Analysis for Hydrophobic Proteins from Dried Blood Spots Enriched by Sodium Carbonate Precipitation.
Daisuke Nakajima; Osamu Ohara; Yusuke Kawashima
Methods in molecular biology (Clifton, N.J.), 2420, 39-52, 2022
Lead - Functional Roles for CD26/DPP4 in Mediating Inflammatory Responses of Pulmonary Vascular Endothelial Cells.
Yukiko Takahashi; Takeshi Kawasaki; Hironori Sato; Yoshinori Hasegawa; Steven M Dudek; Osamu Ohara; Koichiro Tatsumi; Takuji Suzuki
Cells, 10(12), Dec. 2021
Lead - ACC1-expressing pathogenic T helper 2 cell populations facilitate lung and skin inflammation in mice.
Takahiro Nakajima; Toshio Kanno; Satoru Yokoyama; Shigemi Sasamoto; Hikari K Asou; Damon J Tumes; Osamu Ohara; Toshinori Nakayama; Yusuke Endo
The Journal of experimental medicine, 218(12), Dec. 2021
Lead - Acsbg1-dependent mitochondrial fitness is a metabolic checkpoint for tissue Treg cell homeostasis.
Toshio Kanno; Takahiro Nakajima; Yusuke Kawashima; Satoru Yokoyama; Hikari K Asou; Shigemi Sasamoto; Koji Hayashizaki; Yuki Kinjo; Osamu Ohara; Toshinori Nakayama; Yusuke Endo
Cell reports, 37(6), 109921-109921, Nov. 2021
Lead - 血管炎 高安動脈炎全国疫学調査結果とMonogenic Vascu アデノシンデアミナーゼ2(ADA2)欠損症
仁平 寛士; 井澤 和司; 浅井 霞; 伊佐 真彦; 日衛嶋 栄太郎; 小原 収; 西小森 隆太; 八角 高裕
日本小児リウマチ学会総会・学術集会プログラム・抄録集, 30回, 67-67, Oct. 2021
Lead - 次世代プロテオミクスを用いた全身型若年性特発性関節炎(sJIA)患者血清における低発現タンパク群の解析
佐藤 裕範; 井上 祐三朗; 川島 祐介; 小原 收; 下条 直樹
日本小児リウマチ学会総会・学術集会プログラム・抄録集, 30回, 137-137, Oct. 2021
Lead - 新しいスクリーニングの導入に向けた課題と提言 脊髄性筋萎縮症(SMA)スクリーニングの試み
羽田 明; 稲田 佳美; 村山 圭; 高柳 正樹; 細川 淳一; 糸賀 栄; 小原 収
日本マス・スクリーニング学会誌, 31(2), 170-170, Sep. 2021
Lead - Toward proteome-wide exploration of proteins in dried blood spots using liquid chromatography-coupled mass spectrometry.
Daisuke Nakajima; Osamu Ohara; Yusuke Kawashima
Proteomics, 21(23-24), e2100019, Aug. 2021
Lead - Genetic subtype classification using a simplified algorithm and mutational characteristics of diffuse large B-cell lymphoma in a Japanese cohort.
Tatsuzo Mishina; Nagisa Oshima-Hasegawa; Shokichi Tsukamoto; Masaki Fukuyo; Hajime Kageyama; Tomoya Muto; Naoya Mimura; Bahityar Rahmutulla; Yurie Nagai; Kensuke Kayamori; Yutaro Hino; Shio Mitsukawa; Yusuke Takeda; Chikako Ohwada; Masahiro Takeuchi; Hideki Tsujimura; Tohru Iseki; Chiaki Nakaseko; Jun-Ichiro Ikeda; Makiko Itami; Koutaro Yokote; Osamu Ohara; Atsushi Kaneda; Emiko Sakaida
British journal of haematology, 195(5), 731-742, Aug. 2021
Lead - Transplantation of human autologous synovial mesenchymal stem cells with trisomy 7 into the knee joint and 5 years of follow-up.
Mitsuru Mizuno; Kentaro Endo; Hisako Katano; Naoki Amano; Masaki Nomura; Yoshinori Hasegawa; Nobutake Ozeki; Hideyuki Koga; Naoko Takasu; Osamu Ohara; Tomohiro Morio; Ichiro Sekiya
Stem cells translational medicine, 10(11), 1530-1543, Aug. 2021
Lead - Acetate differentially regulates IgA reactivity to commensal bacteria.
Tadashi Takeuchi; Eiji Miyauchi; Takashi Kanaya; Tamotsu Kato; Yumiko Nakanishi; Takashi Watanabe; Toshimori Kitami; Takashi Taida; Takaharu Sasaki; Hiroki Negishi; Shu Shimamoto; Akinobu Matsuyama; Ikuo Kimura; Ifor R Williams; Osamu Ohara; Hiroshi Ohno
Nature, 595(7868), 560-564, Jul. 2021
Lead - Hematopoietic cell transplantation rescues inflammatory bowel disease and dysbiosis of gut microbiota in XIAP deficiency.
Shintaro Ono; Kozue Takeshita; Yuko Kiridoshi; Motohiro Kato; Takahiro Kamiya; Akihiro Hoshino; Masakatsu Yanagimachi; Katsuhiro Arai; Ichiro Takeuchi; Nariaki Toita; Toshihiko Imamura; Yoji Sasahara; Junichi Sugita; Kazuko Hamamoto; Masanobu Takeuchi; Shoji Saito; Masaei Onuma; Hiroshi Tsujimoto; Masahiro Yasui; Takashi Taga; Yuki Arakawa; Yuichi Mitani; Nobuyuki Yamamoto; Kohsuke Imai; Wataru Suda; Masahira Hattori; Osamu Ohara; Tomohiro Morio; Kenya Honda; Hirokazu Kanegane
The journal of allergy and clinical immunology. In practice, 9(10), 3767-3780, Jul. 2021
Lead - A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS.
Motoi Yamashita; Hye Sun Kuehn; Kazuki Okuyama; Satoshi Okada; Yuzaburo Inoue; Noriko Mitsuiki; Kohsuke Imai; Masatoshi Takagi; Hirokazu Kanegane; Masahiro Takeuchi; Naoki Shimojo; Miyuki Tsumura; Aditya K Padhi; Kam Y J Zhang; Bertrand Boisson; Jean-Laurent Casanova; Osamu Ohara; Sergio D Rosenzweig; Ichiro Taniuchi; Tomohiro Morio
Nature immunology, 22(7), 893-903, Jul. 2021
Lead - Multiomic technologies for analyses of inborn errors of immunity: from snapshot of the average cell to dynamic temporal picture at single-cell resolution.
Yusuke Kawashima; Ryuta Nishikomori; Osamu Ohara
Inflammation and regeneration, 41(1), 19-19, Jul. 2021
Lead - SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells.
Toshio Kanno; Takahiro Nakajima; Satoru Yokoyama; Hikari K Asou; Shigemi Sasamoto; Yasuhiro Kamii; Koji Hayashizaki; Yasuo Ouchi; Taishi Onodera; Yoshimasa Takahashi; Kazutaka Ikeda; Yoshinori Hasegawa; Yuki Kinjo; Osamu Ohara; Toshinori Nakayama; Yusuke Endo
Communications biology, 4(1), 820-820, Jun. 2021
Lead - Influenza virus infection expands the breadth of antibody responses through IL-4 signalling in B cells.
Kosuke Miyauchi; Yu Adachi; Keisuke Tonouchi; Taiki Yajima; Yasuyo Harada; Hidehiro Fukuyama; Senka Deno; Yoichiro Iwakura; Akihiko Yoshimura; Hideki Hasegawa; Katsuyuki Yugi; Shin-Ichiro Fujii; Osamu Ohara; Yoshimasa Takahashi; Masato Kubo
Nature communications, 12(1), 3789-3789, Jun. 2021
Lead - Absent XIAP expression in T cell blasts and causal XIAP mutations including non-coding deletion.
Shimaa Said Mohamed Ali Abdrabou; Nariaki Toita; Shin Ichihara; Yusuke Tozawa; Michiko Takahashi; Shin-Ichi Fujiwara; Toshifumi Ashida; Osamu Ohara; Tadashi Ariga; Atsushi Manabe; Mutsuko Konno; Masafumi Yamada
Pediatrics international : official journal of the Japan Pediatric Society, 64(1), e14892, Jun. 2021
Lead - Genomics analysis of leukaemia predisposition in X-linked agammaglobulinaemia.
Akira Nishimura; Takuya Naruto; Satoshi Miyamoto; Andrew Grigg; Julian J Bosco; Akihiro Hoshino; Keishiro Amano; Shotaro Iwamoto; Masahiro Hirayama; Masahiro Migita; Osamu Ohara; Masatoshi Takagi; Tomohiro Morio; Menno C van Zelm; Hirokazu Kanegane
British journal of haematology, 193(6), 1277-1281, Jun. 2021
Lead - Sjögren's syndrome-associated SNPs increase GTF2I expression in salivary gland cells to enhance inflammation development.
Shuhei Shimoyama; Ikuma Nakagawa; Jing-Jing Jiang; Isao Matsumoto; John A Chiorini; Yoshinori Hasegawa; Osamu Ohara; Rie Hasebe; Mitsutoshi Ota; Mona Uchida; Daisuke Kamimura; Shintaro Hojyo; Yuki Tanaka; Tatsuya Atsumi; Masaaki Murakami
International immunology, 33(8), 423-434, May 2021
Lead - Staphylococcus cohnii is a potentially biotherapeutic skin commensal alleviating skin inflammation.
Yoshihiro Ito; Takashi Sasaki; Youxian Li; Takeshi Tanoue; Yuki Sugiura; Ashwin N Skelly; Wataru Suda; Yusuke Kawashima; Nobuyuki Okahashi; Eiichiro Watanabe; Hiroto Horikawa; Aiko Shiohama; Rina Kurokawa; Eiryo Kawakami; Hachiro Iseki; Hiroshi Kawasaki; Yoichiro Iwakura; Atsushi Shiota; Liansheng Yu; Junzo Hisatsune; Haruhiko Koseki; Motoyuki Sugai; Makoto Arita; Osamu Ohara; Takeshi Matsui; Makoto Suematsu; Masahira Hattori; Koji Atarashi; Masayuki Amagai; Kenya Honda
Cell reports, 35(4), 109052-109052, Apr. 2021
Lead - 基礎研究者と共同して構築した便を対象としたData-independent acquisition mass spectrometry(DIA-MS)ベースプロテオーム解析による胆道閉鎖症の早期診断マーカー探索
渡辺 栄一郎; 川島 祐介; 須田 亙; 柿原 知; 高澤 慎也; 中島 大輔; 中村 蓮; 西 明; 鈴木 完; 小原 収; 藤代 準
日本外科学会定期学術集会抄録集, 121回, SF-6, Apr. 2021
Lead - ETV6-related thrombocytopenia associated with a transient decrease in von Willebrand factor.
Yuri Kanamaru; Toru Uchiyama; Tadashi Kaname; Kumiko Yanagi; Osamu Ohara; Shinji Kunishima; Akira Ishiguro
International journal of hematology, 114(2), 297-300, Mar. 2021
Lead - Rapid Flow Cytometry-Based Assay for the Functional Classification of MEFV Variants.
Yoshitaka Honda; Yukako Maeda; Kazushi Izawa; Takeshi Shiba; Takayuki Tanaka; Haruna Nakaseko; Keisuke Nishimura; Hiroki Mukoyama; Masahiko Isa-Nishitani; Takayuki Miyamoto; Hiroshi Nihira; Hirofumi Shibata; Eitaro Hiejima; Osamu Ohara; Junko Takita; Takahiro Yasumi; Ryuta Nishikomori
Journal of clinical immunology, 41(6), 1187-1197, Mar. 2021
Lead - Correction to: Clinical and Immunological Heterogeneity in Japanese Patients with Gain-of-Function Variants in STAT3.
Kay Tanita; Fumiaki Sakura; Ryusuke Nambu; Miyuki Tsumura; Yusuke Imanaka; Hidenori Ohnishi; Zenichiro Kato; Jie Pan; Akihiro Hoshino; Koji Suzuki; Motoko Yasutomi; Shuichiro Umetsu; Chizuru Okada; Masatoshi Takagi; Kohsuke Imai; Osamu Ohara; Alexo M Muise; Satoshi Okada; Tomohiro Morio; Hirokazu Kanegane
Journal of clinical immunology, 41(4), 791-794, Mar. 2021
Lead - A Simple Method for In-Depth Proteome Analysis of Mammalian Cell Culture Conditioned Media Containing Fetal Bovine Serum.
Ren Nakamura; Daisuke Nakajima; Hironori Sato; Yusuke Endo; Osamu Ohara; Yusuke Kawashima
International journal of molecular sciences, 22(5), Mar. 2021
Lead - Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia
Mari Hashimoto; Yoriko Saito; Ryo Nakagawa; Ikuko Ogahara; Shinsuke Takagi; Sadaaki Takata; Hanae Amitani; Mikiko Endo; Hitomi Yuki; Jordan A. Ramilowski; Jessica Severin; Ri-ichiroh Manabe; Takashi Watanabe; Kokoro Ozaki; Akiko Kaneko; Hiroshi Kajita; Saera Fujiki; Kaori Sato; Teruki Honma; Naoyuki Uchida; Takehiro Fukami; Yasushi Okazaki; Osamu Ohara; Leonard D. Shultz; Makoto Yamada; Shuichi Taniguchi; Paresh Vyas; Michiel de Hoon; Yukihide Momozawa; Fumihiko Ishikawa
Nature Cancer, 2(3), 340-356, Mar. 2021
Lead - Identification of Differentially Expressed Proteins in the Serum for Systemic Juvenile Idiopathic Arthritis Using Next-generation Proteomics
Hironori Sato; Yuzaburo Inoue; Yusuke Kawashima; Daisuke Nakajima; Ren Nakamura; Daigo Kato; Kanako Mitsunaga; Takeshi Yamamoto; Akiko Yamaide; Minako Tomiita; Akira Hoshioka; Osamu Ohara; Naoki Shimojo
Feb. 2021
Lead - Inherited CARD9 Deficiency in a Child with Invasive Disease Due to Exophiala dermatitidis and Two Older but Asymptomatic Siblings.
Yusuke Imanaka; Maki Taniguchi; Takehiko Doi; Miyuki Tsumura; Rie Nagaoka; Maiko Shimomura; Takaki Asano; Reiko Kagawa; Yoko Mizoguchi; Shuhei Karakawa; Koji Arihiro; Kohsuke Imai; Tomohiro Morio; Jean-Laurent Casanova; Anne Puel; Osamu Ohara; Katsuhiko Kamei; Masao Kobayashi; Satoshi Okada
Journal of clinical immunology, 41(5), 975-986, Feb. 2021
Lead - Genetic alterations in squamous cell lung cancer associated with idiopathic pulmonary fibrosis.
Atsushi Hata; Takahiro Nakajima; Keisuke Matsusaka; Masaki Fukuyo; Manabu Nakayama; Junichi Morimoto; Yuki Ito; Takayoshi Yamamoto; Yuichi Sakairi; Bahityar Rahmutulla; Satoshi Ota; Hironobu Wada; Hidemi Suzuki; Takekazu Iwata; Hisahiro Matsubara; Osamu Ohara; Ichiro Yoshino; Atsushi Kaneda
International journal of cancer, 148(12), 3008-3018, Feb. 2021
Lead - Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia.
Anne P de Groot; Yoriko Saito; Eiryo Kawakami; Mari Hashimoto; Yuki Aoki; Rintaro Ono; Ikuko Ogahara; Saera Fujiki; Akiko Kaneko; Kaori Sato; Hiroshi Kajita; Takashi Watanabe; Masatoshi Takagi; Daisuke Tomizawa; Katsuyoshi Koh; Mariko Eguchi; Eiichi Ishii; Osamu Ohara; Leonard D Shultz; Shuki Mizutani; Fumihiko Ishikawa
EBioMedicine, 64, 103235-103235, Feb. 2021
Lead - TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemia.
Hiroaki Ochiiwa; Guzhanuer Ailiken; Masataka Yokoyama; Kazuyuki Yamagata; Hidekazu Nagano; Chihoko Yoshimura; Hiromi Muraoka; Keiji Ishida; Tomonori Haruma; Akitoshi Nakayama; Naoko Hashimoto; Kazutaka Murata; Motoi Nishimura; Yusuke Kawashima; Osamu Ohara; Shuichi Ohkubo; Tomoaki Tanaka
Oncogene, 40(7), 1217-1230, Feb. 2021
Lead - Detailed analysis of Japanese patients with adenosine deaminase 2 deficiency reveals characteristic elevation of type II interferon signature and STAT1 hyperactivation.
Hiroshi Nihira; Kazushi Izawa; Moeko Ito; Hiroaki Umebayashi; Tsubasa Okano; Shunsuke Kajikawa; Etsuro Nanishi; Dai Keino; Kosaku Murakami; Masahiko Isa-Nishitani; Takeshi Shiba; Yoshitaka Honda; Atsushi Hijikata; Tadateru Yasu; Tomohiro Kubota; Yoshinori Hasegawa; Yusuke Kawashima; Naoko Nakano; Hidetoshi Takada; Shouichi Ohga; Toshio Heike; Junko Takita; Osamu Ohara; Syuji Takei; Makio Takahashi; Hirokazu Kanegane; Tomohiro Morio; Sachiko Iwaki-Egawa; Yoji Sasahara; Ryuta Nishikomori; Takahiro Yasumi
The Journal of allergy and clinical immunology, 148(2), 550-562, Jan. 2021
Lead - Clinical and Immunological Heterogeneity in Japanese Patients with Gain-of-Function Variants in STAT3.
Kay Tanita; Fumiaki Sakura; Ryusuke Nambu; Miyuki Tsumura; Yusuke Imanaka; Hidenori Ohnishi; Zenichiro Kato; Jie Pan; Akihiro Hoshino; Koji Suzuki; Motoko Yasutomi; Shuichiro Umetsu; Chizuru Okada; Masatoshi Takagi; Kohsuke Imai; Osamu Ohara; Alexo M Muise; Satoshi Okada; Tomohiro Morio; Hirokazu Kanegane
Journal of clinical immunology, 41(4), 780-790, Jan. 2021
Lead - UTERINE EPITHELIAL GP130 ORCHESTRATE EMBRYO IMPLANTATION VIA INCREASED SNAIL FAMILY TRANSCRIPTIONAL REPRESSOR 1 AND ATTENUATED ESTROGEN RESPONSE IN MICE
Osamu Ohara
Placenta, 2021
Lead - Uterine epithelial deletion of Gp130 shows embryo implantation failure in mice
NAMIKI Takafumi; KARAKAMA Harumi; TERAKAWA Jumpei; DAIKOKU Takiko; KAGEYAMA Athuko; HASEGAWA Yoshinori; OHARA Osamu; ITO Junya; KASHIWAZAKI Naomi
The Journal of Reproduction and Development Supplement, 114, AW-4-AW-4, 2021
Lead - Essential Role of STAT3 Signaling in Hair Follicle Homeostasis.
Kosuke Miyauchi; Sewon Ki; Masao Ukai; Yoshie Suzuki; Kentaro Inoue; Wataru Suda; Takeshi Matsui; Yoshihiro Ito; Kenya Honda; Haruhiko Koseki; Osamu Ohara; Reiko J Tanaka; Mariko Okada-Hatakeyama; Masato Kubo
Frontiers in immunology, 12, 663177-663177, 2021
Lead - Wiskott Aldrich Syndrome: A Multi-Institutional Experience From India.
Deepti Suri; Rashmi Rikhi; Ankur K Jindal; Amit Rawat; Murugan Sudhakar; Pandiarajan Vignesh; Anju Gupta; Anit Kaur; Jyoti Sharma; Jasmina Ahluwalia; Prateek Bhatia; Alka Khadwal; Revathi Raj; Ramya Uppuluri; Mukesh Desai; Prasad Taur; Ambreen A Pandrowala; Vijaya Gowri; Manisha R Madkaikar; Harsha Prasada Lashkari; Sagar Bhattad; Harish Kumar; Sanjeev Verma; Kohsuke Imai; Shigeaki Nonoyama; Osamu Ohara; Koon W Chan; Pamela P Lee; Yu Lung Lau; Surjit Singh
Frontiers in immunology, 12, 627651-627651, 2021
Lead - Clinical, Immunological, and Molecular Profile of Chronic Granulomatous Disease: A Multi-Centric Study of 236 Patients From India.
Amit Rawat; Pandiarajan Vignesh; Murugan Sudhakar; Madhubala Sharma; Deepti Suri; Ankur Jindal; Anju Gupta; Jitendra Kumar Shandilya; Sathish Kumar Loganathan; Gurjit Kaur; Sanchi Chawla; Pratap Kumar Patra; Alka Khadwal; Biman Saikia; Ranjana Walker Minz; Vaishali Aggarwal; Prasad Taur; Ambreen Pandrowala; Vijaya Gowri; Mukesh Desai; Manasi Kulkarni; Gauri Hule; Umair Bargir; Priyanka Kambli; Manisha Madkaikar; Sagar Bhattad; Chetan Ginigeri; Harish Kumar; Ananthvikas Jayaram; Deenadayalan Munirathnam; Meena Sivasankaran; Revathi Raj; Ramya Uppuluri; Fouzia Na; Biju George; Harsha Prasada Lashkari; Manas Kalra; Anupam Sachdeva; Shishir Seth; Tapas Sabui; Aman Gupta; Karin van Leeuwen; Martin de Boer; Koon Wing Chan; Kohsuke Imai; Osamu Ohara; Shigeaki Nonoyama; Yu Lung Lau; Surjit Singh
Frontiers in immunology, 12, 625320-625320, 2021
Lead - Hemophagocytic Lymphohistiocytosis in Children with Chronic Granulomatous Disease-Single-Center Experience from North India.
Pandiarajan Vignesh; Sathish Kumar Loganathan; Murugan Sudhakar; Himanshi Chaudhary; Amit Rawat; Megha Sharma; Aravind Shekar; Kim Vaiphei; Narender Kumar; Man-Updesh Singh Sachdeva; Ankur Kumar Jindal; Deepti Suri; Anju Gupta; Pallab Ray; Kohsuke Imai; Osamu Ohara; Shigeaki Nonoyama; Yu Lung Lau; Surjit Singh
The journal of allergy and clinical immunology. In practice, 9(2), 771-782, Nov. 2020
Lead - Discovery of Candidate Stool Biomarker Proteins for Biliary Atresia Using Proteome Analysis by Data-Independent Acquisition Mass Spectrometry.
Eiichiro Watanabe; Yusuke Kawashima; Wataru Suda; Tomo Kakihara; Shinya Takazawa; Daisuke Nakajima; Ren Nakamura; Akira Nishi; Kan Suzuki; Osamu Ohara; Jun Fujishiro
Proteomes, 8(4), Nov. 2020
Lead - CXCR4-Expressing Anti-CD25 CAR T-Cells Effectively Eliminate Human AML Cells In Vivo
Ari Itoh-Nakadai; Yoriko Saito; Mariko Murasawa-Tomizawa; Hiroshi Kajita; Takehisa Matsumoto; Masashi Matsuda; Takashi Watanabe; Mikako Shirouzu; Osamu Ohara; Haruhiko Koseki; Leonard Shultz; Fumihiko Ishikawa
Blood, 136(Supplement 1), 35-36, Nov. 2020
Lead - Japanese patients with mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: In vitro functional analysis of five novel HMGCS2 mutations.
Yasuhiko Ago; Hiroki Otsuka; Hideo Sasai; Elsayed Abdelkreem; Mina Nakama; Yuka Aoyama; Hideki Matsumoto; Ryoji Fujiki; Osamu Ohara; Kazumasa Akiyama; Kaori Fukui; Yoriko Watanabe; Yoko Nakajima; Hidenori Ohnishi; Tetsuya Ito; Toshiyuki Fukao
Experimental and therapeutic medicine, 20(5), 39-39, Nov. 2020
Lead - Clinical characteristics and treatment of 50 cases of Blau syndrome in Japan confirmed by genetic analysis of the NOD2 mutation.
Tomoko Matsuda; Naotomo Kambe; Yoko Ueki; Nobuo Kanazawa; Kazushi Izawa; Yoshitaka Honda; Atsushi Kawakami; Syuji Takei; Kyoko Tonomura; Masami Inoue; Hiroko Kobayashi; Ikuo Okafuji; Yoshihiko Sakurai; Naoki Kato; Yuta Maruyama; Yuzaburo Inoue; Yoshikazu Otsubo; Teruhiko Makino; Satoshi Okada; Ichiro Kobayashi; Masato Yashiro; Shusaku Ito; Hiroshi Fujii; Yasuhiro Kondo; Nami Okamoto; Shuichi Ito; Naomi Iwata; Utako Kaneko; Mototsugu Doi; Junichi Hosokawa; Osamu Ohara; Megumu K Saito; Ryuta Nishikomori
Annals of the rheumatic diseases, 79(11), 1492-1499, Nov. 2020, Refereed, Not invited
Lead - IRAK4 Deficiency Presenting with Anti-NMDAR Encephalitis and HHV6 Reactivation.
Shiho Nishimura; Yoshiyuki Kobayashi; Hidenori Ohnishi; Kunihiko Moriya; Miyuki Tsumura; Sonoko Sakata; Yoko Mizoguchi; Hidetoshi Takada; Zenichiro Kato; Vanessa Sancho-Shimizu; Capucine Picard; Sarosh R Irani; Osamu Ohara; Jean-Laurent Casanova; Anne Puel; Nobutsune Ishikawa; Satoshi Okada; Masao Kobayashi
Journal of clinical immunology, 41(1), 125-135, Oct. 2020
Lead - 遺伝子解析とproteomicsから捉えたGHomaの分子生物学的特徴
大和 梓; 永野 秀和; 橋本 直子; 山形 一行; 福世 真樹; 金田 篤志; 小原 収; 長谷川 嘉則; 福原 紀明; 西岡 宏; 山田 正三; 田中 知明
日本内分泌学会雑誌, 96(2), 502-502, Oct. 2020
Lead - Dysregulated metabolism of polyunsaturated fatty acids in eosinophilic allergic diseases.
Jun Miyata; Koichi Fukunaga; Yusuke Kawashima; Osamu Ohara; Akihiko Kawana; Koichiro Asano; Makoto Arita
Prostaglandins & other lipid mediators, 150, 106477-106477, Oct. 2020, Refereed, Not invited
Lead - Autosomal recessive complete STAT1 deficiency caused by compound heterozygous intronic mutations.
Sonoko Sakata; Miyuki Tsumura; Tadashi Matsubayashi; Shuhei Karakawa; Shunsuke Kimura; Moe Tamaura; Tsubasa Okano; Takuya Naruto; Yoko Mizoguchi; Reiko Kagawa; Shiho Nishimura; Kohsuke Imai; Tom Le Voyer; Jean-Laurent Casanova; Jacinta Bustamante; Tomohiro Morio; Osamu Ohara; Masao Kobayashi; Satoshi Okada
International immunology, 32(10), 663-671, Sep. 2020, Refereed, Not invited
Lead - Clinical phenotypes and genetic analyses for diagnosis of systemic autoinflammatory diseases in adult patients with unexplained fever.
Yukiko Hidaka; Kyoko Fujimoto; Norikazu Matsuo; Takuma Koga; Shinjiro Kaieda; Satoshi Yamasaki; Munetoshi Nakashima; Kiyoshi Migita; Manabu Nakayama; Osamu Ohara; Tomoaki Hoshino; Ryuta Nishikomori; Hiroaki Ida
Modern rheumatology, 31(3), 1-6, Jul. 2020
Lead - Simple and Sensitive Analysis for Dried Blood Spot Proteins by Sodium Carbonate Precipitation for Clinical Proteomics.
Daisuke Nakajima; Yusuke Kawashima; Hirofumi Shibata; Takahiro Yasumi; Masahiko Isa; Kazushi Izawa; Ryuta Nishikomori; Toshio Heike; Osamu Ohara
Journal of proteome research, 19(7), 2821-2827, Jul. 2020, Refereed, Not invited
Lead - Correction: Biallelic GALM pathogenic variants cause a novel type of galactosemia.
Yoichi Wada; Atsuo Kikuchi; Natsuko Arai-Ichinoi; Osamu Sakamoto; Yusuke Takezawa; Shinya Iwasawa; Tetsuya Niihori; Hiromi Nyuzuki; Yoko Nakajima; Erika Ogawa; Mika Ishige; Hiroki Hirai; Hideo Sasai; Ryoji Fujiki; Matsuyuki Shirota; Ryo Funayama; Masayuki Yamamoto; Tetsuya Ito; Osamu Ohara; Keiko Nakayama; Yoko Aoki; Seizo Koshiba; Toshiyuki Fukao; Shigeo Kure
Genetics in medicine : official journal of the American College of Medical Genetics, 22(7), 1281-1281, Jul. 2020
Lead - Whole-Exome Sequencing-Based Approach for Germline Mutations in Patients with Inborn Errors of Immunity.
Tsubasa Okano; Kohsuke Imai; Takuya Naruto; Satoshi Okada; Motoi Yamashita; Tzu-Wen Yeh; Shintaro Ono; Keisuke Tanaka; Keisuke Okamoto; Kay Tanita; Kazuaki Matsumoto; Etsushi Toyofuku; Eri Kumaki-Matsumoto; Miko Okamura; Hiroo Ueno; Seishi Ogawa; Osamu Ohara; Masatoshi Takagi; Hirokazu Kanegane; Tomohiro Morio
Journal of clinical immunology, 40(5), 729-740, Jul. 2020
Lead - PD-L1 Expression Affects Neoantigen Presentation.
Masahiro Okada; Kanako Shimizu; Tomonori Iyoda; Shogo Ueda; Jun Shinga; Yoshiki Mochizuki; Takashi Watanabe; Osamu Ohara; Shin-Ichiro Fujii
iScience, 23(6), 101238-101238, Jun. 2020
Lead - Human gain-of-function STAT1 mutation disturbs IL-17 immunity in mice.
Moe Tamaura; Naoko Satoh-Takayama; Miyuki Tsumura; Takaharu Sasaki; Satoshi Goda; Tomoko Kageyama; Seiichi Hayakawa; Shunsuke Kimura; Takaki Asano; Manabu Nakayama; Haruhiko Koseki; Osamu Ohara; Satoshi Okada; Hiroshi Ohno; Masao Kobayashi
International immunology, 32(4), 259-272, Apr. 2020, Refereed, Not invited
Lead - ISSAID/EMQN Best Practice Guidelines for the Genetic Diagnosis of Monogenic Autoinflammatory Diseases in the Next-Generation Sequencing Era.
Yael Shinar; Isabella Ceccherini; Dorota Rowczenio; Ivona Aksentijevich; Juan Arostegui; Eldad Ben-Chétrit; Guilaine Boursier; Marco Gattorno; Hasmik Hayrapetyan; Hiroaki Ida; Nobuo Kanazawa; Helen J Lachmann; Anna Mensa-Vilaro; Ryuta Nishikomori; Christian Oberkanins; Laura Obici; Osamu Ohara; Seza Ozen; Tamara Sarkisian; Katie Sheils; Nicola Wolstenholme; Evelien Zonneveld-Huijssoon; Marielle E van Gijn; Isabelle Touitou
Clinical chemistry, 66(4), 525-536, Apr. 2020, Refereed, Not invited
Lead - Microfluidic Immunoassays for Time-Resolved Measurement of Protein Secretion from Single Cells.
Mai Yamagishi; Osamu Ohara; Yoshitaka Shirasaki
Annual review of analytical chemistry (Palo Alto, Calif.), 13(1), 67-84, Feb. 2020, Refereed, Not invited
Lead - ゲノム解析時代のprenatal, newborn screening 新生児スクリーニングのためのオミックス計測技術の最近の進歩
小原 收; 中島 大輔; 川島 祐介
日本小児科学会雑誌, 124(2), 170-170, Feb. 2020, Refereed, Not invited
Lead - ろ紙血プロテオームを用いた原発性免疫不全症における新生児スクリーニングの可能性
柴田 洋史; 八角 高裕; 前田 由可子; 宮本 尚幸; 伊佐 真彦; 本田 吉孝; 田中 孝之; 井澤 和司; 川島 祐介; 大西 秀典; 石村 匡崇; 今井 耕輔; 小野寺 雅史; 小原 收; 滝田 順子
日本小児科学会雑誌, 124(2), 300-300, Feb. 2020, Refereed, Not invited
Lead - THE FEASIBILITY OF NEWBORN MASS SCREENING FOR PRIMARY HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS USING DRIED BLOOD SPOT (DBS) PROTEOMICS
Shibata, Hirofumi; Yasumi, Takahiro; Shimodera, Saeko; Masahiko, Isa-Nishitani; Izawa, Kazushi; Ohnishi, Hidenori; Nakajima, Daisuke; Kawashima, Yusuke; Nishikomori, Ryuta; Ohara, Osamu; Takita, Junko;
Pediatric blood & cancer, 67, S30-S30, Feb. 2020 - HaloTag-based conjugation of proteins to barcoding-oligonucleotides.
Junshi Yazaki; Yusuke Kawashima; Taisaku Ogawa; Atsuo Kobayashi; Mayu Okoshi; Takashi Watanabe; Suguru Yoshida; Isao Kii; Shohei Egami; Masayuki Amagai; Takamitsu Hosoya; Katsuyuki Shiroguchi; Osamu Ohara
Nucleic acids research, 48(2), e8, Jan. 2020, Refereed, Not invited
Lead - Prognostic factors for survival of herpes simplex virus-associated hemophagocytic lymphohistiocytosis.
Motoshi Sonoda; Masataka Ishimura; Katsuhide Eguchi; Akira Shiraishi; Shunsuke Kanno; Noriyuki Kaku; Hirosuke Inoue; Yoshitomo Motomura; Masayuki Ochiai; Yasunari Sakai; Manabu Nakayama; Osamu Ohara; Shouichi Ohga
International journal of hematology, 111(1), 131-136, Jan. 2020, Refereed, Not invited
Lead - Omics analysis for diagnosis of protein deficiencies
Yusuke Kawashima; Osamu Ohara
Japanese Journal of Clinical Chemistry, 49(3), 192-198, 2020
Lead - Generation and Profiling of 2,135 Human ESC Lines for the Systematic Analyses of Cell States Perturbed by Inducing Single Transcription Factors
Osamu Ohara
Cell Reports, 2020
Lead - THE FEASIBILITY OF NEWBORN MASS SCREENING FOR PRIMARY HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS USING DRIED BLOOD SPOT (DBS) PROTEOMICS
Osamu Ohara
Pediatric Blood and Cancer, 2020
Lead - Genomic Analysis of Diffuse Large B Cell Lymphoma in a Japanese Cohort Using Targeted DNA Sequencing
Osamu Ohara
Blood, 2020
Lead - ISSAID and EMQN best practice guidelines for gene panel based diagnosis of autoinflammatory diseases
Osamu Ohara
European Journal of Human Genetics, 2020
Lead - Clinical, Immunological, and Molecular Features of Severe Combined Immune Deficiency: A Multi-Institutional Experience From India.
Pandiarajan Vignesh; Amit Rawat; Rajni Kumrah; Ankita Singh; Anjani Gummadi; Madhubala Sharma; Anit Kaur; Johnson Nameirakpam; Ankur Jindal; Deepti Suri; Anju Gupta; Alka Khadwal; Biman Saikia; Ranjana Walker Minz; Kaushal Sharma; Mukesh Desai; Prasad Taur; Vijaya Gowri; Ambreen Pandrowala; Aparna Dalvi; Neha Jodhawat; Priyanka Kambli; Manisha Rajan Madkaikar; Sagar Bhattad; Stalin Ramprakash; Raghuram Cp; Ananthvikas Jayaram; Meena Sivasankaran; Deenadayalan Munirathnam; Sarath Balaji; Aruna Rajendran; Amita Aggarwal; Komal Singh; Fouzia Na; Biju George; Ankit Mehta; Harsha Prasada Lashkari; Ramya Uppuluri; Revathi Raj; Sandip Bartakke; Kirti Gupta; Sreejesh Sreedharanunni; Yumi Ogura; Tamaki Kato; Kohsuke Imai; Koon Wing Chan; Daniel Leung; Osamu Ohara; Shigeaki Nonoyama; Michael Hershfield; Yu-Lung Lau; Surjit Singh
Frontiers in immunology, 11, 619146-619146, 2020
Lead - Clinical and Genetic Profile of X-Linked Agammaglobulinemia: A Multicenter Experience From India.
Amit Rawat; Ankur Kumar Jindal; Deepti Suri; Pandiarajan Vignesh; Anju Gupta; Biman Saikia; Ranjana W Minz; Aaqib Zaffar Banday; Rahul Tyagi; Kanika Arora; Vibhu Joshi; Sanjib Mondal; Jitendra Kumar Shandilya; Madhubala Sharma; Mukesh Desai; Prasad Taur; Ambreen Pandrowala; Vijaya Gowri; Sneha Sawant-Desai; Maya Gupta; Aparna Dhondi Dalvi; Manisha Madkaikar; Amita Aggarwal; Revathi Raj; Ramya Uppuluri; Sagar Bhattad; Ananthvikas Jayaram; Harsha Prasad Lashkari; Liza Rajasekhar; Deenadayalan Munirathnam; Manas Kalra; Anuj Shukla; Ruchi Saka; Rajni Sharma; Ravinder Garg; Kohsuke Imai; Shigeaki Nonoyama; Osamu Ohara; Pamela P Lee; Koon Wing Chan; Yu-Lung Lau; Surjit Singh
Frontiers in immunology, 11, 612323-612323, 2020
Lead - Novel HADHB mutations in a patient with mitochondrial trifunctional protein deficiency.
Mina Nakama; Hideo Sasai; Mitsuru Kubota; Yuki Hasegawa; Ryoji Fujiki; Torayuki Okuyama; Osamu Ohara; Toshiyuki Fukao
Human genome variation, 7, 10-10, 2020, Refereed, Not invited
Lead - Generation and Profiling of 2,135 Human ESC Lines for the Systematic Analyses of Cell States Perturbed by Inducing Single Transcription Factors
Nakatake, Yuhki; Ko, Shigeru B. H.; Sharov, Alexei A.; Wakabayashi, Shunichi; Murakami, Miyako; Sakota, Miki; Chikazawa, Nana; Ookura, Chiaki; Sato, Saeko; Ito, Noriko; Ishikawa-Hirayama, Madoka; Mak, Siu Shan; Jakt, Lars Martin; Ueno, Tomoo; Hiratsuka, Ken; Matsushita, Misako; Goparaju, Sravan Kumar; Akiyama, Tomohiko; Ishiguro, Kei-ichiro; Oda, Mayumi; Gouda, Norio; Umezawa, Akihiro; Akutsu, Hidenori; Nishimura, Kunihiro; Matoba, Ryo; Ohara, Osamu; Ko, Minoru S. H.;
CELL REPORTS, 31(7), 2020 - Optimization of Data-Independent Acquisition Mass Spectrometry for Deep and Highly Sensitive Proteomic Analysis.
Yusuke Kawashima; Eiichiro Watanabe; Taichi Umeyama; Daisuke Nakajima; Masahira Hattori; Kenya Honda; Osamu Ohara
International journal of molecular sciences, 20(23), Nov. 2019, Refereed, Not invited
Lead - Short DNA Probes Developed for Sample Tracking and Quality Assurance in Gene Panel Testing.
Ryoji Fujiki; Makoto Ikeda; Osamu Ohara
The Journal of molecular diagnostics : JMD, 21(6), 1079-1094, Nov. 2019, Refereed, Not invited
Lead - A deep intronic mutation of c.1166-285 T > G in SLC46A1 is shared by four unrelated Japanese patients with hereditary folate malabsorption (HFM).
Yusuke Tozawa; Shimaa Said Mohamed Ali Abdrabou; Natsuko Nogawa-Chida; Ritsuo Nishiuchi; Toshiaki Ishida; Yuichi Suzuki; Hideki Sano; Ryoji Kobayashi; Kenji Kishimoto; Osamu Ohara; Kohsuke Imai; Takuya Naruto; Kunihiko Kobayashi; Tadashi Ariga; Masafumi Yamada
Clinical immunology (Orlando, Fla.), 208, 108256-108256, Nov. 2019, Refereed, Not invited
Lead - Low-frequency mosaicism in cryopyrin-associated periodic fever syndrome: mosaicism in systemic autoinflammatory diseases.
Ryuta Nishikomori; Kazushi Izawa; Naotomo Kambe; Osamu Ohara; Takahiro Yasumi
International immunology, 31(10), 649-655, Sep. 2019, Refereed, Not invited
Lead - 子宮上皮におけるシグナル伝達兼転写活性化因子3(Stat3)は、プロジェステロンシグナルを介して胚着床を制御する
白杉 豊; 工藤 大和; 並木 貴文; 影山 敦子; 寺川 純平; 大黒 多希子; 前澤 創; 長谷川 嘉則; 小原 収; 佐藤 政充; 伊藤 潤哉; 柏崎 直巳
The Journal of Reproduction and Development, 65(Suppl.), j80-j80, Sep. 2019
Lead - TGF-β signaling promotes tube-structure-forming growth in pancreatic duct adenocarcinoma.
Takashi Yamaguchi; Sanae Ikehara; Yoshihiro Akimoto; Hayao Nakanishi; Masahiko Kume; Kazuo Yamamoto; Osamu Ohara; Yuzuru Ikehara
Scientific reports, 9(1), 11247-11247, Aug. 2019, Refereed, Not invited
Lead - BTNL2 germline variants may be involved in the pathogenesis of renal granuloma.
Toyoki Nishimura; Ai Yamada; Mariko Kinoshita; Osamu Ohara; Hiroshi Moritake
Pediatrics international : official journal of the Japan Pediatric Society, 61(8), 834-836, Aug. 2019, Refereed, Not invited
Lead - Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis.
Keigo Nishida; Aiko Hasegawa; Satoru Yamasaki; Ryota Uchida; Wakana Ohashi; Yosuke Kurashima; Jun Kunisawa; Shunsuke Kimura; Toshihiko Iwanaga; Hiroshi Watarai; Koji Hase; Hideki Ogura; Manabu Nakayama; Jun-Ichi Kashiwakura; Yoshimichi Okayama; Masato Kubo; Osamu Ohara; Hiroshi Kiyono; Haruhiko Koseki; Masaaki Murakami; Toshio Hirano
Scientific reports, 9(1), 10842-10842, Jul. 2019, Refereed, Not invited
Lead - Genetic and transcriptional landscape of plasma cells in POEMS syndrome.
Yuhei Nagao; Naoya Mimura; June Takeda; Kenichi Yoshida; Yusuke Shiozawa; Motohiko Oshima; Kazumasa Aoyama; Atsunori Saraya; Shuhei Koide; Ola Rizq; Yoshinori Hasegawa; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Dai Nishijima; Yusuke Isshiki; Kensuke Kayamori; Chika Kawajiri-Manako; Nagisa Oshima-Hasegawa; Shokichi Tsukamoto; Shio Mitsukawa; Yusuke Takeda; Chikako Ohwada; Masahiro Takeuchi; Tohru Iseki; Sonoko Misawa; Satoru Miyano; Osamu Ohara; Koutaro Yokote; Emiko Sakaida; Satoshi Kuwabara; Masashi Sanada; Atsushi Iwama; Seishi Ogawa; Chiaki Nakaseko
Leukemia, 33(7), 1723-1735, Jul. 2019, Refereed, Not invited
Lead - Biallelic GALM pathogenic variants cause a novel type of galactosemia.
Yoichi Wada; Atsuo Kikuchi; Natsuko Arai-Ichinoi; Osamu Sakamoto; Yusuke Takezawa; Shinya Iwasawa; Tetsuya Niihori; Hiromi Nyuzuki; Yoko Nakajima; Erika Ogawa; Mika Ishige; Hiroki Hirai; Hideo Sasai; Ryoji Fujiki; Matsuyuki Shirota; Ryo Funayama; Masayuki Yamamoto; Tetsuya Ito; Osamu Ohara; Keiko Nakayama; Yoko Aoki; Seizo Koshiba; Toshiyuki Fukao; Shigeo Kure
Genetics in medicine : official journal of the American College of Medical Genetics, 21(6), 1286-1294, Jun. 2019, Refereed, Not invited
Lead - Antiviral activity of zinc sulfate against hepatitis A virus replication
Ogawa, Masahiro; Kanda, Tatsuo; Suganami, Akiko; Nakamoto, Shingo; Win, Nan Nwe; Tamura, Yutaka; Nakamura, Masato; Matsuoka, Shunichi; Yokosuka, Osamu; Kato, Naoya; Ohara, Osamu; Okamoto, Hiroaki; Moriyama, Mitsuhiko; Shirasawa, Hiroshi;
FUTURE VIROLOGY, 14(6), 399-406, Jun. 2019 - Eomes transcription factor is required for the development and differentiation of invariant NKT cells
Osamu Ohara
Communications Biology, 2(1), 150, Apr. 2019, Refereed, Not invited
Lead - Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice.
Masashi Matsuda; Rintaro Ono; Tomonori Iyoda; Takaho Endo; Makoto Iwasaki; Mariko Tomizawa-Murasawa; Yoriko Saito; Akiko Kaneko; Kanako Shimizu; Daisuke Yamada; Narumi Ogonuki; Takashi Watanabe; Manabu Nakayama; Yoko Koseki; Fuyuko Kezuka-Shiotani; Takanori Hasegawa; Hiromasa Yabe; Shunichi Kato; Atsuo Ogura; Leonard D Shultz; Osamu Ohara; Masaru Taniguchi; Haruhiko Koseki; Shin-Ichiro Fujii; Fumihiko Ishikawa
Life science alliance, 2(2), Apr. 2019, Refereed, Not invited
Lead - PLD4 is a genetic determinant to systemic lupus erythematosus and involved in murine autoimmune phenotypes.
Shuji Akizuki; Kazuyoshi Ishigaki; Yuta Kochi; Sze-Ming Law; Keitaro Matsuo; Koichiro Ohmura; Akari Suzuki; Manabu Nakayama; Yusuke Iizuka; Haruhiko Koseki; Osamu Ohara; Jun Hirata; Yoichiro Kamatani; Fumihiko Matsuda; Takayuki Sumida; Kazuhiko Yamamoto; Yukinori Okada; Tsuneyo Mimori; Chikashi Terao
Annals of the rheumatic diseases, 78(4), 509-518, Apr. 2019, Refereed, Not invited
Lead - Inhibition of T cell activation and function by the adaptor protein CIN85.
Kong MS; Hashimoto-Tane A; Kawashima Y; Sakuma M; Yokosuka T; Kometani K; Onishi R; Carpino N; Ohara O; Kurosaki T; Phua KK; Saito T
Science signaling, 12(567), Feb. 2019, Refereed, Not invited
Lead - Co-activation of macrophages and T cells contribute to chronic GVHD in human IL-6 transgenic humanised mouse model.
Ono R; Watanabe T; Kawakami E; Iwasaki M; Tomizawa-Murasawa M; Matsuda M; Najima Y; Takagi S; Fujiki S; Sato R; Mochizuki Y; Yoshida H; Sato K; Yabe H; Kato S; Saito Y; Taniguchi S; Shultz LD; Ohara O; Amagai M; Koseki H; Ishikawa F
EBioMedicine, 41, 584-596, Feb. 2019, Refereed, Not invited
Lead - Rescue of recurrent deep intronic mutation underlying cell type-dependent quantitative NEMO deficiency.
Bertrand Boisson; Yoshitaka Honda; Masahiko Ajiro; Jacinta Bustamante; Matthieu Bendavid; Andrew R Gennery; Yuri Kawasaki; Jose Ichishima; Mitsujiro Osawa; Hiroshi Nihira; Takeshi Shiba; Takayuki Tanaka; Maya Chrabieh; Benedetta Bigio; Hong Hur; Yuval Itan; Yupu Liang; Satoshi Okada; Kazushi Izawa; Ryuta Nishikomori; Osamu Ohara; Toshio Heike; Laurent Abel; Anne Puel; Megumu K Saito; Jean-Laurent Casanova; Masatoshi Hagiwara; Takahiro Yasumi
The Journal of clinical investigation, 129(2), 583-597, Feb. 2019, Refereed, Not invited
Lead - Hematopoietic stem cell transplantation for progressive combined immunodeficiency and lymphoproliferation in patients with activated phosphatidylinositol-3-OH kinase δ syndrome type 1.
Tsubasa Okano; Kohsuke Imai; Yuki Tsujita; Noriko Mitsuiki; Kenichi Yoshida; Chikako Kamae; Kenichi Honma; Kanako Mitsui-Sekinaka; Yujin Sekinaka; Tamaki Kato; Katsuyuki Hanabusa; Eri Endo; Takehiro Takashima; Haruka Hiroki; Tzu-Wen Yeh; Keisuke Tanaka; Masakazu Nagahori; Ikuya Tsuge; Yuki Bando; Fuminori Iwasaki; Yoshiaki Shikama; Masami Inoue; Tomiko Kimoto; Naohiko Moriguchi; Yuki Yuza; Takashi Kaneko; Kyoko Suzuki; Tomoyo Matsubara; Yoshihiro Maruo; Tomoaki Kunitsu; Tomoko Waragai; Hideki Sano; Yuko Hashimoto; Kazuhiro Tasaki; Osamu Suzuki; Toshihiko Shirakawa; Motohiro Kato; Toru Uchiyama; Masataka Ishimura; Tetsuzo Tauchi; Hiroshi Yagasaki; Shiann-Tarng Jou; Hsin-Hui Yu; Hirokazu Kanegane; Sven Kracker; Anne Durandy; Daiei Kojima; Hideki Muramatsu; Taizo Wada; Yuzaburo Inoue; Hidetoshi Takada; Seiji Kojima; Seishi Ogawa; Osamu Ohara; Shigeaki Nonoyama; Tomohiro Morio
The Journal of allergy and clinical immunology, 143(1), 266-275, Jan. 2019, Refereed, Not invited
Lead - Mosaicism of an ELANE Mutation in an Asymptomatic Mother
Osamu Ohara
Journal of Clinical Immunology, 39(1), 106-111, Jan. 2019, Refereed, Not invited
Lead - Dysregulated fatty acid metabolism in nasal polyp-derived eosinophils from patients with chronic rhinosinusitis.
Miyata J; Fukunaga K; Kawashima Y; Watanabe T; Saitoh A; Hirosaki T; Araki Y; Kikawada T; Betsuyaku T; Ohara O; Arita M
Allergy, 74(6), 1113-1124, Jan. 2019, Refereed, Not invited
Lead - Whole-exome sequencing in unresectable pancreatic cancer patients with long-term survival
Osamu Ohara
Journal of Clinical Oncology, 2019
Lead - Molecular Study in Children with Chronic Granulomatous Disease (CGD) at a Tertiary Care Center in North India
Osamu Ohara
Journal of Clinical Immunology, 2019
Lead - H. pylori epigenome micro-evolution associated with DNA methyltransferases' sequence-specificity changes
Osamu Ohara
Helicobacter, 2019
Lead - Antiviral activity of zinc sulfate against hepatitis A virus replication
Osamu Ohara
Future Virology, 2019
Lead - Eomes transcription factor is required for the development and differentiation of invariant NKT cells.
Kanako Shimizu; Yusuke Sato; Masami Kawamura; Hiroshi Nakazato; Takashi Watanabe; Osamu Ohara; Shin-Ichiro Fujii
Communications biology, 2, 150-150, 2019, Refereed, Not invited
Lead - Autosomal dominant Hashimoto's thyroiditis with a mutation in TNFAIP3.
Tomohiro Hori; Hidenori Ohnishi; Tomonori Kadowaki; Norio Kawamoto; Hideki Matsumoto; Osamu Ohara; Toshiyuki Fukao
Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology, 28(3), 91-96, 2019, Refereed, Not invited
Lead - Detection of MYD88 L265P mutation by next-generation deep sequencing in peripheral blood mononuclear cells of Waldenström's macroglobulinemia and IgM monoclonal gammopathy of undetermined significance.
Ayako Nakamura; Chikako Ohwada; Masahiro Takeuchi; Yusuke Takeda; Shokichi Tsukamoto; Naoya Mimura; Oshima-Hasegawa Nagisa; Yasumasa Sugita; Hiroaki Tanaka; Hisashi Wakita; Nobuyuki Aotsuka; Kosei Matsue; Koutaro Yokote; Osamu Ohara; Chiaki Nakaseko; Emiko Sakaida
PloS one, 14(9), e0221941, 2019, Refereed, Not invited
Lead - PCR-free whole exome sequencing: Cost-effective and efficient in detecting rare mutations.
Izumi Yamaguchi; Takashi Watanabe; Osamu Ohara; Yoshinori Hasegawa
PloS one, 14(9), e0222562, 2019, Refereed, Not invited
Lead - Recurrent Acute Abdomen as the Main Manifestation of Hereditary Angioedema
Osamu Ohara
Internal Medicine, 2019, Refereed, Not invited
Lead - [MULTIOMICS ANALYSIS OF HUMAN EOSINOPHILS REVEALED MOLECULAR MECHANISM OF EOSINOPHILIC RHINOSINUSITIS AND SEVERE ASTHMA].
Miyata J; Kawashima Y; Ohara O; Betsuyaku T; Fukunaga K; Arita M
Arerugi = [Allergy], 68(2), 86-91, 2019, Refereed, Not invited
Lead - 子宮上皮におけるシグナル伝達兼転写活性化因子3（Stat3）は，プロジェステロンシグナルを介して胚着床を制御する
白杉 豊;佐藤 政充;伊藤 潤哉;柏崎 直巳;工藤 大和;並木 貴文;影山 敦子;寺川 純平;大黒 多希子;前澤 創;長谷川 嘉則;小原 収
日本繁殖生物学会 講演要旨集, 112, OR2-5, 2019 - Generation of orthotopically functional salivary gland from embryonic stem cells
Junichi Tanaka; Miho Ogawa; Hironori Hojo; Yusuke Kawashima; Yo Mabuchi; Kenji Hata; Shiro Nakamura; Rika Yasuhara; Koki Takamatsu; Tarou Irié; Toshiyuki Fukada; Takayoshi Sakai; Tomio Inoue; Riko Nishimura; Osamu Ohara; Ichiro Saito; Shinsuke Ohba; Takashi Tsuji; Kenji Mishima
Nature Communications, 9(1), 4216, Dec. 2018, Refereed, Not invited
Lead - Development of a NanoLC-MS/MS System Using a Nonporous Reverse Phase Column for Ultrasensitive Proteome Analysis
Osamu Ohara
Analytical Chemistry, 90(21), 12334-12338, Nov. 2018, Refereed, Not invited
Lead - Clinical and Immunological Characterization of ICF Syndrome in Japan.
Chikako Kamae; Kohsuke Imai; Tamaki Kato; Tsubasa Okano; Kenichi Honma; Noriko Nakagawa; Tzu-Wen Yeh; Emiko Noguchi; Akira Ohara; Tomonari Shigemura; Hiroshi Takahashi; Shunichi Takakura; Masatoshi Hayashi; Aoi Honma; Seiichi Watanabe; Tomoko Shigemori; Osamu Ohara; Hiroyuki Sasaki; Takeo Kubota; Tomohiro Morio; Hirokazu Kanegane; Shigeaki Nonoyama
Journal of clinical immunology, 38(8), 927-937, Nov. 2018, Refereed, Not invited
Lead - Proteogenomic Analyses of Cellular Lysates Using a Phenol-Guanidinium Thiocyanate Reagent.
Kawashima Y; Miyata J; Watanabe T; Shioya J; Arita M; Ohara O
Journal of proteome research, 18(1), 301-308, Nov. 2018, Refereed, Not invited
Lead - Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC
Osamu Ohara
Cell, 175(5), 1289-1306.e20, Nov. 2018, Refereed, Not invited
Lead - Clinical and molecular features of X-linked hyper IgM syndrome - An experience from North India.
Amit Rawat; Babu Mathew; Vignesh Pandiarajan; Ankur Jindal; Madhubala Sharma; Deepti Suri; Anju Gupta; Shubham Goel; Adil Karim; Biman Saikia; Ranjana W Minz; Kohsuke Imai; Shigeaki Nonoyama; Osamu Ohara; Silvia Clara Giliani; Luigi D Notarangelo; Koon-Wing Chan; Yu-Lung Lau; Surjit Singh
Clinical immunology (Orlando, Fla.), 195, 59-66, Oct. 2018, Refereed, Not invited
Lead - ヒト化マウスモデルを用いた急性、ならびに慢性移植片対宿主病(GVHD)の病態生理の解明(Understanding pathophysiology of acute and chronic graft-versus-host disease using humanized mice)
小野 林太郎; 渡辺 貴志; 川上 英良; 村澤 麻利子; 松田 正史; 名島 悠峰; 望月 芳樹; 吉田 尚弘; 佐藤 薫; 矢部 普正; 加藤 俊一; 齊藤 頼子; Shultz Leonard D.; 小原 收; 天谷 雅行; 古関 明彦; 石川 文彦
臨床血液, 59(9), 1515-1515, Sep. 2018
Lead - Comprehensive molecular diagnosis of Epstein-Barr virus-associated lymphoproliferative diseases using next-generation sequencing.
Shintaro Ono; Manabu Nakayama; Hirokazu Kanegane; Akihiro Hoshino; Saeko Shimodera; Hirofumi Shibata; Hisanori Fujino; Takahiro Fujino; Yuta Yunomae; Tsubasa Okano; Motoi Yamashita; Takahiro Yasumi; Kazushi Izawa; Masatoshi Takagi; Kohsuke Imai; Kejian Zhang; Rebecca Marsh; Capucine Picard; Sylvain Latour; Osamu Ohara; Tomohiro Morio
International journal of hematology, 108(3), 319-328, Sep. 2018, Refereed, Not invited
Lead - Assessing the Accuracy of Variant Detection in Cost-Effective Gene Panel Testing by Next-Generation Sequencing.
Ryoji Fujiki; Makoto Ikeda; Akiko Yoshida; Maeda Akiko; Yue Yao; Motio Nishimura; Kazuyuki Matsushita; Tomohiko Ichikawa; Tomoaki Tanaka; Hiroko Morisaki; Takayuki Morisaki; Osamu Ohara
The Journal of molecular diagnostics : JMD, 20(5), 572-582, Sep. 2018, Refereed, Not invited
Lead - Variant PRC1 competes with retinoic acid-related signals to repress Meis2 in distal forelimb bud.
Yakushiji-Kaminatsui N; Kondo T; Hironaka KI; Sharif J; Endo TA; Nakayama M; Masui O; Koseki Y; Kondo K; Ohara O; Vidal M; Morishita Y; Koseki H
Development (Cambridge, England), 145(19), Sep. 2018, Refereed, Not invited
Lead - Sox12 promotes T reg differentiation in the periphery during colitis.
Tanaka S; Suto A; Iwamoto T; Kageyama T; Tamachi T; Takatori H; Suzuki K; Hirose K; Ohara O; Lefebvre V; Nakajima H
The Journal of experimental medicine, 215(10), 2509-2519, Sep. 2018, Refereed, Not invited
Lead - 次世代シーケンサーによる滑膜幹細胞の核型解析 核型異常が軟骨分化に影響するか
水野 満; 大関 信武; 片野 尚子; 小田邉 浩二; 馬渕 洋; 赤澤 智宏; 古賀 英之; 長谷川 嘉則; 小原 収; 大川 淳; 関矢 一郎
日本整形外科学会雑誌, 92(8), S1970-S1970, Aug. 2018
Lead - 新生児スクリーニングにおける千葉県の取り組み
松永 綾子[藤浪]; 鶴岡 智子; 秋山 奈々; 朽方 豊夢; 倉信 奈緒美; 伏見 拓矢; 小原 収; 大竹 明; 高柳 正樹; 村山 圭
日本マス・スクリーニング学会誌, 28(2), 238-238, Jul. 2018, Refereed, Not invited
Lead - Development of a molecular diagnostic test for Retinitis Pigmentosa in the Japanese population
Akiko Maeda; Akiko Yoshida; Kanako Kawai; Yuki Arai; Ryutaro Akiba; Akira Inaba; Seiji Takagi; Ryoji Fujiki; Yasuhiko Hirami; Yasuo Kurimoto; Osamu Ohara; Masayo Takahashi
Japanese Journal of Ophthalmology, 62(4), 451-457, Jul. 2018, Refereed, Not invited
Lead - A novel truncating mutation in FLNA causes periventricular nodular heterotopia, Ehlers-Danlos-like collagenopathy and macrothrombocytopenia
Daisuke Ieda; Ikumi Hori; Yuji Nakamura; Hironori Ohshita; Yutaka Negishi; Tsutomu Shinohara; Ayako Hattori; Takenori Kato; Sachiko Inukai; Katsumasa Kitamura; Tomoki Kawai; Osamu Ohara; Shinji Kunishima; Shinji Saitoh
Brain and Development, 40(6), 489-492, Jun. 2018, Refereed, Not invited
Lead - Characterization of a large UNC13D gene duplication in a patient with familial hemophagocytic lymphohistiocytosis type 3.
Eitaro Hiejima; Hirofumi Shibata; Takahiro Yasumi; Saeko Shimodera; Masayuki Hori; Kazushi Izawa; Tomoki Kawai; Masaki Matsuoka; Yasuko Kojima; Akira Ohara; Ryuta Nishikomori; Osamu Ohara; Toshio Heike
Clinical immunology (Orlando, Fla.), 191, 63-66, Jun. 2018, Refereed, Not invited
Lead - Human CTL-based functional analysis shows the reliability of a munc13-4 protein expression assay for FHL3 diagnosis.
Hirofumi Shibata; Takahiro Yasumi; Saeko Shimodera; Eitaro Hiejima; Kazushi Izawa; Tomoki Kawai; Ryutaro Shirakawa; Taizo Wada; Ryuta Nishikomori; Hisanori Horiuchi; Osamu Ohara; Eiichi Ishii; Toshio Heike
Blood, 131(18), 2016-2025, May 2018, Refereed, Not invited
Lead - 原発性マクログロブリン血症およびIgM MGUS患者の末梢血単核球を用いた次世代シーケンサーによるMYD88 L265P遺伝子変異解析
大和田 千桂子; 仲村 彩子; 武内 正博; 竹田 勇輔; 塚本 祥吉; 三村 尚也; 大島 渚; 杉田 泰雅; 田中 宏明; 脇田 久; 青墳 信之; 末永 孝生; 小原 收; 中世古 知昭; 堺田 惠美子
International Journal of Myeloma, 8(2), 102-102, May 2018, Not invited
Lead - Deregulated mucosal immune surveillance through gut-Associated regulatory t cells and PD-1+ t cells in human colorectal cancer
Hanae Fujimoto; Yoriko Saito; Kenoki Ohuchida; Eiryo Kawakami; Saera Fujiki; Takashi Watanabe; Rintaro Ono; Akiko Kaneko; Shinsuke Takagi; Yuho Najima; Atsushi Hijikata; Lin Cui; Takashi Ueki; Yoshinao Oda; Shohei Hori; Osamu Ohara; Masafumi Nakamura; Takashi Saito; Fumihiko Ishikawa
Journal of Immunology, 200(9), 3291-3303, May 2018, Refereed, Not invited
Lead - Identification of Protein Targets of 12/15-Lipoxygenase-Derived Lipid Electrophiles in Mouse Peritoneal Macrophages Using Omega-Alkynyl Fatty Acid
Yosuke Isobe; Yusuke Kawashima; Tomoaki Ishihara; Kenji Watanabe; Osamu Ohara; Makoto Arita
ACS Chemical Biology, 13(4), 887-893, Apr. 2018, Refereed, Not invited
Lead - Haploinsufficiency of A20 causes autoinflammatory and autoimmune disorders.
Tomonori Kadowaki; Hidenori Ohnishi; Norio Kawamoto; Tomohiro Hori; Kenichi Nishimura; Chie Kobayashi; Tomonari Shigemura; Shohei Ogata; Yuzaburo Inoue; Tomoki Kawai; Eitaro Hiejima; Masatoshi Takagi; Kohsuke Imai; Ryuta Nishikomori; Shuichi Ito; Toshio Heike; Osamu Ohara; Tomohiro Morio; Toshiyuki Fukao; Hirokazu Kanegane
The Journal of allergy and clinical immunology, 141(4), 1485-1488, Apr. 2018, Refereed, Not invited
Lead - Haploinsufficiency of A20 causes autoinflammatory and autoimmune disorders.
Tomonori Kadowaki; Hidenori Ohnishi; Norio Kawamoto; Tomohiro Hori; Kenichi Nishimura; Chie Kobayashi; Tomonari Shigemura; Shohei Ogata; Yuzaburo Inoue; Tomoki Kawai; Eitaro Hiejima; Masatoshi Takagi; Kohsuke Imai; Ryuta Nishikomori; Shuichi Ito; Toshio Heike; Osamu Ohara; Tomohiro Morio; Toshiyuki Fukao; Hirokazu Kanegane
The Journal of allergy and clinical immunology, 141(4), 1485-1488, Apr. 2018, Refereed, Not invited
Lead - National survey of Japanese patients with mevalonate kinase deficiency reveals distinctive genetic and clinical characteristics.
Tanaka T; Yoshioka K; Nishikomori R; Sakai H; Abe J; Yamashita Y; Hiramoto R; Morimoto A; Ishii E; Arakawa H; Kaneko U; Ohshima Y; Okamoto N; Ohara O; Hata I; Shigematsu Y; Kawai T; Yasumi T; Heike T
Modern rheumatology, 29(1), 1-7, Mar. 2018, Refereed, Not invited
Lead - Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection.
Shen-Ying Zhang; Nathaniel E Clark; Catherine A Freije; Elodie Pauwels; Allison J Taggart; Satoshi Okada; Hanna Mandel; Paula Garcia; Michael J Ciancanelli; Anat Biran; Fabien G Lafaille; Miyuki Tsumura; Aurélie Cobat; Jingchuan Luo; Stefano Volpi; Bastian Zimmer; Sonoko Sakata; Alexandra Dinis; Osamu Ohara; Eduardo J Garcia Reino; Kerry Dobbs; Mary Hasek; Stephen P Holloway; Karen McCammon; Stacy A Hussong; Nicholas DeRosa; Candice E Van Skike; Adam Katolik; Lazaro Lorenzo; Maki Hyodo; Emilia Faria; Rabih Halwani; Rie Fukuhara; Gregory A Smith; Veronica Galvan; Masad J Damha; Saleh Al-Muhsen; Yuval Itan; Jef D Boeke; Luigi D Notarangelo; Lorenz Studer; Masao Kobayashi; Luisa Diogo; William G Fairbrother; Laurent Abel; Brad R Rosenberg; P John Hart; Amos Etzioni; Jean-Laurent Casanova
Cell, 172(5), 952-965, Feb. 2018, Refereed, Not invited
Lead - NK cell and IFN signatures are positive prognostic biomarkers for resectable pancreatic cancer.
Hoshikawa M; Aoki T; Matsushita H; Karasaki T; Hosoi A; Odaira K; Fujieda N; Kobayashi Y; Kambara K; Ohara O; Arita J; Hasegawa K; Kakimi K; Kokudo N
Biochemical and biophysical research communications, 495(2), 2058-2065, Jan. 2018, Refereed, Not invited
Lead - Novel genetic variants in a cohort of severe combined immunodeficiency from India
Osamu Ohara
Journal of Clinical Immunology, 2018
Lead - Improving the efficiency of gene insertion in a human artificial chromosome vector and its transfer in human-induced pluripotent stem cells.
Yoshinori Hasegawa; Masashi Ikeno; Nobutaka Suzuki; Manabu Nakayama; Osamu Ohara
Biology methods & protocols, 3(1), bpy013, 2018
Lead - Enhanced AKT Phosphorylation of Circulating B Cells in Patients With Activated PI3Kδ Syndrome.
Takaki Asano; Satoshi Okada; Miyuki Tsumura; Tzu-Wen Yeh; Kanako Mitsui-Sekinaka; Yuki Tsujita; Youjiro Ichinose; Akira Shimada; Kunio Hashimoto; Taizo Wada; Kohsuke Imai; Osamu Ohara; Tomohiro Morio; Shigeaki Nonoyama; Masao Kobayashi
Frontiers in immunology, 9, 568-568, 2018, Refereed, Not invited
Lead - Challenges in Developing Protein Secretion Assays at a Single-Cell Level.
Shirasaki Y; Ohara O
Methods in molecular biology (Clifton, N.J.), 1808, 1-7, 2018, Refereed, Not invited
Lead - Late-onset ornithine transcarbamylase deficiency caused by a somatic mosaic mutation.
Lee T; Misaki M; Shimomura H; Tanaka Y; Yoshida S; Murayama K; Nakamura K; Fujiki R; Ohara O; Sasai H; Fukao T; Takeshima Y
Human genome variation, 5(1), 22, 2018, Refereed, Not invited
Lead - Live Cell Imaging of Secretion (LCI-S) to track the dynamics of cytokine production from individual immune cells
Yoshitaka Shirasaki; Kaede Miyata; Yumiko Tanaka; Mai Yamagishi; Nobutake Suzuki; Pie Baba; Hiroki Kabata; Koichi Fukunaga; Tomoko Betsuyaku; Osamu Ohara; Kazuyo Moro; Sotaro Uemura
CYTOKINE, 100, 60-61, Dec. 2017, Refereed, Not invited
Lead - Rbm10 regulates inflammation development via alternative splicing of Dnmt3b
Toru Atsumi; Hironao Suzuki; Jing-Jing Jiang; Yuko Okuyama; Ikuma Nakagawa; Mitsutoshi Ota; Yuki Tanaka; Takuto Ohki; Kokichi Katsunuma; Koichi Nakajima; Yoshinori Hasegawa; Osamu Ohara; Hideki Ogura; Yasunobu Arima; Daisuke Kamimura; Masaaki Murakami
International Immunology, 29(12), 581-591, Dec. 2017, Refereed, Not invited
Lead - Generation of safe and therapeutically effective human induced pluripotent stem cell-derived hepatocyte-like cells for regenerative medicine.
Kazuo Takayama; Naoki Akita; Natsumi Mimura; Rina Akahira; Yukimasa Taniguchi; Makoto Ikeda; Fuminori Sakurai; Osamu Ohara; Tomohiro Morio; Kiyotoshi Sekiguchi; Hiroyuki Mizuguchi
Hepatology communications, 1(10), 1058-1069, Dec. 2017, Refereed, Not invited
Lead - A Novel CTL-Based Functional Assay Reveals a Strong Correlation between the Pathogenic of an UNC13D Variant and the Instability of its Translated MUNC13-4 Protein: MUNC13-4 Protein Expression Assay is a Reliable Method for Identification of Patients
Hirofumi Shibata; Takahiro Yasumi; Saeko Shimodera; Eitaro Hiejima; Kazushi Izawa; Tomoki Kawai; Ryutaro Shirakawa; Taizo Wada; Ryuta Nishikomori; Hisanori Horiuchi; Osamu Ohara; Toshio Heike
PEDIATRIC BLOOD & CANCER, 64, S34-S35, Nov. 2017, Refereed, Not invited
Lead - Heterozygous carriers of succinyl-CoA:3-oxoacid CoA transferase deficiency can develop severe ketoacidosis
Hideo Sasai; Yuka Aoyama; Hiroki Otsuka; Elsayed Abdelkreem; Yasuhiro Naiki; Mitsuru Kubota; Yuji Sekine; Masatsune Itoh; Mina Nakama; Hidenori Ohnishi; Ryoji Fujiki; Osamu Ohara; Toshiyuki Fukao
JOURNAL OF INHERITED METABOLIC DISEASE, 40(6), 845-852, Nov. 2017, Refereed, Not invited
Lead - Newborn screening for carnitine palmitoyltransferase II deficiency using (C16+C18:1)/C2: Evaluation of additional indices for adequate sensitivity and lower false-positivity
Go Tajima; Keiichi Hara; Miyuki Tsumura; Reiko Kagawa; Satoshi Okada; Nobuo Sakura; Shinsuke Maruyama; Atsuko Noguchi; Tomonari Awaya; Mika Ishige; Nobuyuki Ishige; Ikuma Musha; Sayaka Ajihara; Akira Ohtake; Etsuo Naito; Yusuke Hamada; Tomotaka Kono; Tomoko Asada; Hideo Sasai; Toshiyuki Fukao; Ryoji Fujiki; Osamu Ohara; Ryosuke Bo; Kenji Yamada; Hironori Kobayashi; Yuki Hasegawa; Seiji Yamaguchi; Masaki Takayanagi; Ikue Hata; Yosuke Shigematsu; Masao Kobayashi
MOLECULAR GENETICS AND METABOLISM, 122(3), 67-75, Nov. 2017, Refereed, Not invited
Lead - Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10-p63 axis in epithelial homeostasis
Bum-Ho Bin; Jinhyuk Bhin; Mikiro Takaishi; Koh-ei Toyoshima; Saeko Kawamata; Kana Ito; Takafumi Hara; Takashi Watanabe; Tarou Irie; Teruhisa Takagishi; Su-Hyon Lee; Haeng-Sun Jung; Sangchul Rho; Juyeon Seo; Dong-Hwa Choi; Daehee Hwang; Haruhiko Koseki; Osamu Ohara; Shigetoshi Sano; Takashi Tsuji; Kenji Mishima; Toshiyuki Fukada
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114(46), 12243-12248, Nov. 2017, Refereed, Not invited
Lead - EPC1/TIP60-Mediated Histone Acetylation Facilitates Spermiogenesis in Mice
Yixin Dong; Kyo-ichi Isono; Kazuyuki Ohbo; Takaho A. Endo; Osamu Ohara; Mamiko Maekawa; Yoshiro Toyama; Chizuru Ito; Kiyotaka Toshimori; Kristian Helin; Narumi Ogonuki; Kimiko Inoue; Atsuo Ogura; Kazutsune Yamagata; Issay Kitabayashi; Haruhiko Koseki
MOLECULAR AND CELLULAR BIOLOGY, 37(19), Oct. 2017, Refereed, Not invited
Lead - Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways
Yoriko Saito; Yoshiki Mochizuki; Ikuko Ogahara; Takashi Watanabe; Leah Hogdal; Shinsuke Takagi; Kaori Sato; Akiko Kaneko; Hiroshi Kajita; Naoyuki Uchida; Takehiro Fukami; Leonard D. Shultz; Shuichi Taniguchi; Osamu Ohara; Anthony G. Letai; Fumihiko Ishikawa
SCIENCE TRANSLATIONAL MEDICINE, 9(413), Oct. 2017, Refereed, Not invited
Lead - AB017. Gene panel study for target metabolic diseases of newborn screening in Japan.
Sasai H; Fujiki R; Ohara O; Nakajima Y; Ito T; Kobayashi M; Tajima G; Sakamoto O; Matsumoto S; Nakamura K; Hamazaki T; Hasegawa Y; Kobayashi H; Fukao T
Annals of Translational Medicine, Sep. 2017
Lead - Immunodeficiency in Two Female Patients with Incontinentia Pigmenti with Heterozygous NEMO Mutation Diagnosed by LPS Unresponsiveness
Hidenori Ohnishi; Yuka Kishimoto; Tomohide Taguchi; Norio Kawamoto; Mina Nakama; Tomoki Kawai; Manabu Nakayama; Osamu Ohara; Kenji Orii; Toshiyuki Fukao
JOURNAL OF CLINICAL IMMUNOLOGY, 37(6), 529-538, Aug. 2017, Refereed, Not invited
Lead - Common Variable Immunodeficiency Caused by FANC Mutations
Yujin Sekinaka; Noriko Mitsuiki; Kohsuke Imai; Miharu Yabe; Hiromasa Yabe; Kanako Mitsui-Sekinaka; Kenichi Honma; Masatoshi Takagi; Ayako Arai; Kenichi Yoshida; Yusuke Okuno; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Hideki Muramatsu; Seiji Kojima; Asuka Hira; Minoru Takata; Osamu Ohara; Seishi Ogawa; Tomohiro Morio; Shigeaki Nonoyama
Journal of Clinical Immunology, 37(5), 434-444, Jul. 2017, Refereed, Not invited
Lead - Alanine-scanning mutagenesis of human signal transducer and activator of transcription 1 to estimate loss- or gain-of-function variants
Reiko Kagawa; Ryoji Fujiki; Miyuki Tsumura; Sonoko Sakata; Shiho Nishimura; Yuval Itan; Xiao-Fei Kong; Zenichiro Kato; Hidenori Ohnishi; Osamu Hirata; Satoshi Saito; Maiko Ikeda; Jamila El Baghdadi; Aziz Bousfiha; Kaori Fujiwara; Matias Oleastro; Judith Yancoski; Laura Perez; Silvia Danielian; Fatima Ailal; Hidetoshi Takada; Toshiro Hara; Anne Puel; Stephanie Boisson-Dupuis; Jacinta Bustamante; Jean-Laurent Casanova; Osamu Ohara; Satoshi Okada; Masao Kobayashi
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 140(1), 232-241, Jul. 2017, Refereed, Not invited
Lead - I kappa BNS enhances follicular helper T-cell differentiation and function downstream of ASCI2
Junichi Hosokawa; Kotaro Suzuki; Kazuyuki Meguro; Shigeru Tanaka; Yuko Maezawa; Akira Suto; Lisa Fujimura; Akemi Sakamoto; Hans Clevers; Osamu Ohara; Hiroshi Nakajima
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 140(1), 288-+, Jul. 2017, Refereed, Not invited
Lead - Common Variable Immunodeficiency Caused by FANC Mutations
Yujin Sekinaka; Noriko Mitsuiki; Kohsuke Imai; Miharu Yabe; Hiromasa Yabe; Kanako Mitsui-Sekinaka; Kenichi Honma; Masatoshi Takagi; Ayako Arai; Kenichi Yoshida; Yusuke Okuno; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Hideki Muramatsu; Seiji Kojima; Asuka Hira; Minoru Takata; Osamu Ohara; Seishi Ogawa; Tomohiro Morio; Shigeaki Nonoyama
JOURNAL OF CLINICAL IMMUNOLOGY, 37(5), 434-444, Jul. 2017, Refereed, Not invited
Lead - Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases
Tetsuro Matsuhashi; Takeya Sato; Shin-ichiro Kanno; Takehiro Suzuki; Akihiro Matsuo; Yuki Oba; Motoi Kikusato; Emi Ogasawara; Tai Kudo; Kosuke Suzuki; Osamu Ohara; Hiroko Shimbo; Fumika Nanto; Hiroaki Yamaguchi; Daisuke Saigusa; Yasuno Mukaiyama; Akiko Watabe; Koichi Kikuchi; Hisato Shima; Eikan Mishima; Yasutoshi Akiyama; Yoshitsugu Oikawa; Hsin-Jung Ho; Yukako Akiyama; Chitose Suzuki; Mitsugu Uematsu; Masaki Ogata; Naonori Kumagai; Masaaki Toyomizu; Atsushi Hozawa; Nariyasu Mano; Yuji Owada; Setsuya Aiba; Teruyuki Yanagisawa; Yoshihisa Tomioka; Shigeo Kure; Sadayoshi Ito; Kazuto Nakada; Ken-ichiro Hayashi; Hitoshi Osaka; Takaaki Abe
EBIOMEDICINE, 20, 27-38, Jun. 2017, Refereed, Not invited
Lead - A novel KCNQ1 nonsense variant in the isoform-specific first exon causes both jervell and Lange-Nielsen syndrome 1 and long QT syndrome 1: a case report.
Nishimura M; Ueda M; Ebata R; Utsuno E; Ishii T; Matsushita K; Ohara O; Shimojo N; Kobayashi Y; Nomura F
BMC medical genetics, 18(1), 66, Jun. 2017, Refereed, Not invited
Lead - An Immunogram for the Cancer-Immunity Cycle: Towards Personalized Immunotherapy of Lung Cancer.
Takahiro Karasaki; Kazuhiro Nagayama; Hideki Kuwano; Jun-Ichi Nitadori; Masaaki Sato; Masaki Anraku; Akihiro Hosoi; Hirokazu Matsushita; Yasuyuki Morishita; Kosuke Kashiwabara; Masaki Takazawa; Osamu Ohara; Kazuhiro Kakimi; Jun Nakajima
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 12(5), 791-803, May 2017, Refereed, Not invited
Lead - Nationwide survey of Baller-Gerold syndrome in Japanese population
Hideo Kaneko; Rie Izumi; Hirotsugu Oda; Osamu Ohara; Kiyoko Sameshima; Hidenori Ohnishi; Toshiyuki Fukao; Michinori Funato
MOLECULAR MEDICINE REPORTS, 15(5), 3222-3224, May 2017, Refereed, Not invited
Lead - Infection Profile in Chronic Granulomatous Disease: a 23-Year Experience from a Tertiary Care Center in North India
Amit Rawat; Pandiarajan Vignesh; Avinash Sharma; Jitendra K. Shandilya; Madhubala Sharma; Deepti Suri; Anju Gupta; Vikas Gautam; Pallab Ray; Shivaprakash M. Rudramurthy; Arunaloke Chakrabarti; Kohsuke Imai; Shigeaki Nonoyama; Osamu Ohara; Yu L. Lau; Surjit Singh
Journal of Clinical Immunology, 37(3), 319-328, Apr. 2017, Refereed, Not invited
Lead - Molecular mechanism and structural basis of gain-of-function of STAT1 caused by pathogenic R274Q mutation
Ryoji Fujiki; Atsushi Hijikata; Tsuyoshi Shirai; Satoshi Okada; Masao Kobayashi; Osamu Ohara
JOURNAL OF BIOLOGICAL CHEMISTRY, 292(15), 6240-6254, Apr. 2017, Refereed, Not invited
Lead - Infection Profile in Chronic Granulomatous Disease: a 23-Year Experience from a Tertiary Care Center in North India
Amit Rawat; Pandiarajan Vignesh; Avinash Sharma; Jitendra K. Shandilya; Madhubala Sharma; Deepti Suri; Anju Gupta; Vikas Gautam; Pallab Ray; Shivaprakash M. Rudramurthy; Arunaloke Chakrabarti; Kohsuke Imai; Shigeaki Nonoyama; Osamu Ohara; Yu L. Lau; Surjit Singh
JOURNAL OF CLINICAL IMMUNOLOGY, 37(3), 319-328, Apr. 2017, Refereed, Not invited
Lead - Critical involvement of ZEB2 in collagen fibrillogenesis: the molecular similarity between Mowat-Wilson syndrome and Ehlers-Danlos syndrome
Mika Teraishi; Mikiro Takaishi; Kimiko Nakajima; Mitsunori Ikeda; Yujiro Higashi; Shinji Shimoda; Yoshinobu Asada; Atsushi Hijikata; Osamu Ohara; Yoko Hiraki; Seiji Mizuno; Toshiyuki Fukada; Takahisa Furukawa; Nobuaki Wakamatsu; Shigetoshi Sano
SCIENTIFIC REPORTS, 7, 46565, Apr. 2017, Refereed, Not invited
Lead - Correction: PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes.
Endoh M; Endo TA; Shinga J; Hayashi K; Farcas A; Ma KW; Ito S; Sharif J; Endoh T; Onaga N; Nakayama M; Ishikura T; Masui O; Kessler BM; Suda T; Ohara O; Okuda A; Klose RJ; Koseki H
eLife, 6, Apr. 2017, Refereed, Not invited
Lead - Alternative pathway for the development of V(alpha)14(+) NKT cells directly from CD4(-)CD8(-) thymocytes that bypasses the CD4(+)CD8(+) stage
Nyambayar Dashtsoodol; Tomokuni Shigeura; Minako Aihara; Ritsuko Ozawa; Satoshi Kojo; Michishige Harada; Takaho A. Endo; Takashi Watanabe; Osamu Ohara; Masaru Taniguchi
NATURE IMMUNOLOGY, 18(3), 274-282, Mar. 2017, Refereed, Not invited
Lead - PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes
Mitsuhiro Endoh; Takaho A. Endo; Jun Shinga; Katsuhiko Hayashi; Anca Farcas; Kit-Wan Ma; Shinsuke Ito; Jafar Sharif; Tamie Endoh; Naoko Onaga; Manabu Nakayama; Tomoyuki Ishikura; Osamu Masui; Benedikt M. Kessler; Toshio Suda; Osamu Ohara; Akihiko Okuda; Robert Klose; Haruhiko Koseki
ELIFE, 6, Mar. 2017, Refereed, Not invited
Lead - A deletion in the intergenic region upstream of Ednrb causes head spot in the rat strain KFRS4/Kyo
Minako Yoshihara; Tetsuya Sato; Daisuke Saito; Osamu Ohara; Takashi Kuramoto; Mikita Suyama
BMC GENETICS, 18(1), 29, Mar. 2017, Refereed, Not invited
Lead - Accurate clinical genetic testing for autoinflammatory diseases using the next-generation sequencing platform MiSeq.
Manabu Nakayama; Hirotsugu Oda; Kenji Nakagawa; Takahiro Yasumi; Tomoki Kawai; Kazushi Izawa; Ryuta Nishikomori; Toshio Heike; Osamu Ohara
Biochemistry and biophysics reports, 9, 146-152, Mar. 2017, Refereed, Not invited
Lead - Pyoderma Gangrenosum, Acne and Suppurative Hidradenitis Syndrome Treated with Granulocyte and Monocyte Adsorption Apheresis
Yoko Mizutani; Tomomi Okano; Tomoko Takahashi; Hidenori Ohnishi; Osamu Ohara; Akiyo Sano; Mariko Seishima
ACTA DERMATO-VENEREOLOGICA, 97(2), 275-276, Feb. 2017, Refereed, Not invited
Lead - Widespread Molluscum Contagiosum with Atopic Dermatitis-like Skin Manifestations
Sakiko Chikazawa; Sayaka Takai; Aiko Furuya; Tamaki Kato; Osamu Ohara; Takashi Hashimoto; Shigeaki Nonoyama; Takahiro Satoh
ACTA DERMATO-VENEREOLOGICA, 97(2), 291-292, Feb. 2017, Refereed, Not invited
Lead - Identification of a High-Frequency Somatic NLRC4 Mutation as a Cause of Autoinflammation by Pluripotent Cell-Based Phenotype Dissection
Yuri Kawasaki; Hirotsugu Oda; Jun Ito; Akira Niwa; Takayuki Tanaka; Atsushi Hijikata; Ryosuke Seki; Ayako Nagahashi; Mitsujiro Osawa; Isao Asaka; Akira Watanabe; Shigeo Nishimata; Tsuyoshi Shirai; Hisashi Kawashima; Osamu Ohara; Tatsutoshi Nakahata; Ryuta Nishikomori; Toshio Heike; Megumu K. Saito
ARTHRITIS & RHEUMATOLOGY, 69(2), 447-459, Feb. 2017, Refereed, Not invited
Lead - Prediction and prioritization of neoantigens: integration of RNA sequencing data with whole-exome sequencing
Takahiro Karasaki; Kazuhiro Nagayama; Hideki Kuwano; Jun-ichi Nitadori; Masaaki Sato; Masaki Anraku; Akihiro Hosoi; Hirokazu Matsushita; Masaki Takazawa; Osamu Ohara; Jun Nakajima; Kazuhiro Kakimi
CANCER SCIENCE, 108(2), 170-177, Feb. 2017, Refereed, Not invited
Lead - A Japanese family case with juvenile onset Behçet's disease caused by TNFAIP3 mutation.
Ohnishi H; Kawamoto N; Seishima M; Ohara O; Fukao T
Allergology international : official journal of the Japanese Society of Allergology, 66(1), 146, Jan. 2017, Refereed, Not invited
Lead - A Japanese family case with juvenile onset Behcet's disease caused by TNFAIP3 mutation
Hidenori Ohnishi; Norio Kawamoto; Mariko Seishima; Osamu Ohara; Toshiyuki Fukao
ALLERGOLOGY INTERNATIONAL, 66(1), 146-148, Jan. 2017, Refereed, Not invited
Lead - A CD57(+) CTL Degranulation Assay Effectively Identifies Familial Hemophagocytic Lymphohistiocytosis Type 3 Patients
Masayuki Hori; Takahiro Yasumi; Saeko Shimodera; Hirofumi Shibata; Eitaro Hiejima; Hirotsugu Oda; Kazushi Izawa; Tomoki Kawai; Masataka Ishimura; Naoko Nakano; Ryutaro Shirakawa; Ryuta Nishikomori; Hidetoshi Takada; Satoshi Morita; Hisanori Horiuchi; Osamu Ohara; Eiichi Ishii; Toshio Heike
JOURNAL OF CLINICAL IMMUNOLOGY, 37(1), 92-99, Jan. 2017, Refereed, Not invited
Lead - Mapping the Interactome of a Major Mammalian Endoplasmic Reticulum Heat Shock Protein 90
Feng Hong; Saleh Mohammad Rachidi; Debbie Lundgren; David Han; Xiu Huang; Hongyu Zhao; Yayoi Kimura; Hisashi Hirano; Osamu Ohara; Heichiiro Udono; Songdong Meng; Bei Liu; Zihai Li
PLOS ONE, 12(1), e0169260, Jan. 2017, Refereed, Not invited
Lead - Time evolution of microenvironment around cells regulated by the secretion activity and culture density of the cells.
Array,Yutaka Hori; Sotaro Uemura; Osamu Ohara; Yoshitaka Shirasaki
International Symposium on Micro-NanoMechatronics and Human Science, MHS 2017, Nagoya, Japan, December 3-6, 2017, 1-5, 2017, Refereed, Not invited
Lead - Efficient Regeneration of Human V alpha 24(+) Invariant Natural Killer T Cells and Their Anti-Tumor Activity In Vivo
Daisuke Yamada; Tomonori Iyoda; Raul Vizcardo; Kanako Shimizu; Yusuke Sato; Takaho A. Endo; Genta Kitahara; Momoko Okoshi; Midori Kobayashi; Maki Sakurai; Osamu Ohara; Masaru Taniguchi; Haruhiko Koseki; Shin-Ichiro Fujii
STEM CELLS, 34(12), 2852-2860, Dec. 2016, Refereed, Not invited
Lead - Phosphatase and tensin homolog (PTEN) mutation can cause activated phosphatidylinositol 3-kinase delta syndrome-like immunodeficiency
Yuki Tsujita; Kanako Mitsui-Sekinaka; Kohsuke Imai; Tzu-Wen Yeh; Noriko Mitsuiki; Takaki Asano; Hidenori Ohnishi; Zenichiro Kato; Yujin Sekinaka; Kiyotaka Zaha; Tamaki Kato; Tsubasa Okano; Takehiro Takashima; Kaoru Kobayashi; Mitsuaki Kimura; Tomoaki Kunitsu; Yoshihiro Maruo; Hirokazu Kanegane; Masatoshi Takagi; Kenichi Yoshida; Yusuke Okuno; Hideki Muramatsu; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Seiji Kojima; Seishi Ogawa; Osamu Ohara; Satoshi Okada; Masao Kobayashi; Tomohiro Morio; Shigeaki Nonoyama
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 138(6), 1672-+, Dec. 2016, Refereed, Not invited
Lead - Protective neutralizing influenza antibody response in the absence of T follicular helper cells
Kosuke Miyauchi; Akiko Sugimoto-Ishige; Yasuyo Harada; Yu Adachi; Yoshiko Usami; Tomohiro Kaji; Kentaro Inoue; Hideki Hasegawa; Takashi Watanabe; Atsushi Hijikata; Satoshi Fukuyama; Tadashi Maemura; Mariko Okada-Hatakeyama; Osamu Ohara; Yoshihiro Kawaoka; Yoshimasa Takahashi; Toshitada Takemori; Masato Kubo
NATURE IMMUNOLOGY, 17(12), 1447-1458, Dec. 2016, Refereed, Not invited
Lead - Application of target capture sequencing of exons and conserved non-coding sequences to 20 inbred rat strains.
Yoshihara M; Sato T; Saito D; Ohara O; Kuramoto T; Suyama M
Genomics data, 10, 155-157, Dec. 2016, Refereed, Not invited
Lead - Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency
Romain Levy; Satoshi Okada; Vivien Beziat; Kunihiko Moriya; Caini Liu; Louis Yi Ann Chai; Melanie Migaud; Fabian Hauck; Amein Al Ali; Cyril Cyrus; Chittibabu Vatte; Turkan Patiroglu; Ekrem Unal; Marie Ferneiny; Nobuyuki Hyakuna; Serdar Nepesov; Matias Oleastro; Aydan Ikinciogullari; Figen Dogu; Takaki Asano; Osamu Ohara; Ling Yun; Erika Della Mina; Didier Bronnimann; Yuval Itan; Florian Gothe; Jacinta Bustamante; Stephanie Boisson-Dupuis; Natalia Tahuil; Caner Aytekin; Aicha Salhi; Saleh Al Muhsen; Masao Kobayashi; Julie Toubiana; Laurent Abel; Xiaoxia Li; Yildiz Camcioglu; Fatih Celmeli; Christoph Klein; Suzan A. AlKhater; Jean-Laurent Casanova; Anne Puel
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(51), E8277-E8285, Dec. 2016, Refereed, Not invited
Lead - Clinical and Genetic Features of Patients With TNFRSF1A Variants in Japan: Findings of a Nationwide Survey
Naoyasu Ueda; Hiroaki Ida; Masakazu Washio; Hisaaki Miyahara; Shoji Tokunaga; Fumiko Tanaka; Hiroki Takahashi; Koichi Kusuhara; Koichiro Ohmura; Manabu Nakayama; Osamu Ohara; Ryuta Nishikomori; Seiji Minota; Shuji Takei; Takao Fujii; Yoshiaki Ishigatsubo; Hiroshi Tsukamoto; Tomoko Tahira; Takahiko Horiuchi
ARTHRITIS & RHEUMATOLOGY, 68(11), 2760-2771, Nov. 2016, Refereed, Not invited
Lead - Establishment of a new three-dimensional human epidermal model reconstructed from plucked hair follicle-derived keratinocytes
Michiyo Nakano; Noriaki Kamada; Keisuke Suehiro; Ayako Oikawa; Chihori Shibata; Yuumi Nakamura; Hiroyuki Matsue; Yusuke Sasahara; Hiroyuki Hosokawa; Toshinori Nakayama; Ken Nonaka; Osamu Ohara
EXPERIMENTAL DERMATOLOGY, 25(11), 903-906, Nov. 2016, Refereed, Not invited
Lead - Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress
Wakana Ohashi; Shunsuke Kimura; Toshihiko Iwanaga; Yukihiro Furusawa; Tarou Irie; Hironori Izumi; Takashi Watanabe; Atsushi Hijikata; Takafumi Hara; Osamu Ohara; Haruhiko Koseki; Toshiro Sato; Sylvie Robine; Hisashi Mori; Yuichi Hattori; Hiroshi Watarai; Kenji Mishima; Hiroshi Ohno; Koji Hase; Toshiyuki Fukada
PLOS GENETICS, 12(10), Oct. 2016, Refereed, Not invited
Lead - A case of selective IgG subclass deficiency with STAT3 mutation
Hidenori Ohnishi; Norio Kawamoto; Hideo Kaneko; Kimiko Kasahara; Osamu Ohara; Zenichiro Kato; Toshiyuki Fukao
Allergology International, 65(4), 495-497, Oct. 2016, Refereed, Not invited
Lead - X-linked agammaglobulinemia: Twenty years of single-center experience from North West India
Surjit Singh; Amit Rawat; Deepti Suri; Anju Gupta; Ravinder Garg; Biman Saikia; Ranjana Walker Minz; Shobha Sehgal; Koon-Wing Chan; Yu Lung Lau; Chikako Kamae; Kenichi Honma; Noriko Nakagawa; Kohsuke Imai; Shigeaki Nonoyama; Koichi Oshima; Noriko Mitsuiki; Osamu Ohara
Annals of Allergy, Asthma and Immunology, 117(4), 405-411, Oct. 2016, Refereed, Not invited
Lead - Novel compound heterozygous mutations in a Japanese girl with Janus kinase 3 deficiency
Takeshi Sato; Tsubasa Okano; Mari Tanaka-Kubota; Shunsuke Kimura; Satoshi Miyamoto; Shintaro Ono; Motoi Yamashita; Noriko Mitsuiki; Masatoshi Takagi; Kohsuke Imai; Michiko Kajiwara; Takasuke Ebato; Shohei Ogata; Hirotsugu Oda; Osamu Ohara; Hirokazu Kanegane; Tomohiro Morio
Pediatrics International, 58(10), 1076-1080, Oct. 2016, Refereed, Not invited
Lead - A case of selective IgG subclass deficiency with STAT3 mutation
Osamu Ohara
Allergology International, 65(4), 495-497, Oct. 2016, Refereed, Not invited
Lead - X-linked agammaglobulinemia Twenty years of single-center experience from North West India
Surjit Singh; Amit Rawat; Deepti Suri; Anju Gupta; Ravinder Garg; Biman Saikia; Ranjana Walker Minz; Shobha Sehgal; Koon-Wing Chan; Yu Lung Lau; Chikako Kamae; Kenichi Honma; Noriko Nakagawa; Kohsuke Imai; Shigeaki Nonoyama; Koichi Oshima; Noriko Mitsuiki; Osamu Ohara
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 117(4), 405-411, Oct. 2016, Refereed, Not invited
Lead - Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress.
Wakana Ohashi; Shunsuke Kimura; Toshihiko Iwanaga; Yukihiro Furusawa; Tarou Irié; Hironori Izumi; Takashi Watanabe; Atsushi Hijikata; Takafumi Hara; Osamu Ohara; Haruhiko Koseki; Toshiro Sato; Sylvie Robine; Hisashi Mori; Yuichi Hattori; Hiroshi Watarai; Kenji Mishima; Hiroshi Ohno; Koji Hase; Toshiyuki Fukada
PLoS genetics, 12(10), e1006349, Oct. 2016, Refereed, Not invited
Lead - Novel compound heterozygous mutations in a Japanese girl with Janus kinase 3 deficiency
Takeshi Sato; Tsubasa Okano; Mari Tanaka-Kubota; Shunsuke Kimura; Satoshi Miyamoto; Shintaro Ono; Motoi Yamashita; Noriko Mitsuiki; Masatoshi Takagi; Kohsuke Imai; Michiko Kajiwara; Takasuke Ebato; Shohei Ogata; Hirotsugu Oda; Osamu Ohara; Hirokazu Kanegane; Tomohiro Morio
PEDIATRICS INTERNATIONAL, 58(10), 1076-1080, Oct. 2016, Refereed, Not invited
Lead - Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop
Makoto Kuwahara; Wataru Ise; Mizuki Ochi; Junpei Suzuki; Kohei Kometani; Saho Maruyama; Maya Izumoto; Akira Matsumoto; Nobuaki Takemori; Ayako Takemori; Kenta Shinoda; Toshinori Nakayama; Osamu Ohara; Masaki Yasukawa; Tatsuya Sawasaki; Tomohiro Kurosaki; Masakatsu Yamashita
NATURE COMMUNICATIONS, 7, 12596, Sep. 2016, Refereed, Not invited
Lead - De Novo Assembly of the Transcriptome of Turritopsis, a Jellyfish That Repeatedly Rejuvenates
Yoshinori Hasegawa; Takashi Watanabe; Masaki Takazawa; Osamu Ohara; Shin Kubota
ZOOLOGICAL SCIENCE, 33(4), 366-371, Aug. 2016, Refereed, Not invited
Lead - Design and application of a target capture sequencing of exons and conserved non-coding sequences for the rat
Minako Yoshihara; Daisuke Saito; Tetsuya Sato; Osamu Ohara; Takashi Kuramoto; Mikita Suyama
BMC GENOMICS, 17, 593, Aug. 2016, Refereed, Not invited
Lead - Activation of Endogenous Retroviruses in Dnmt1(-/-) ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA
Jafar Sharif; Takaho A. Endo; Manabu Nakayama; Mohammad M. Karimi; Midori Shimada; Kayoko Katsuyama; Preeti Goyal; Julie Brind'Amour; Ming-An Sun; Zhixiong Sun; Tomoyuki Ishikura; Yoko Mizutani-Koseki; Osamu Ohara; Yoichi Shinkai; Makoto Nakanishi; Hehuang Xie; Matthew C. Lorincz; Haruhiko Koseki
CELL STEM CELL, 19(1), 81-94, Jul. 2016, Refereed, Not invited
Lead - Micro-adhesion rings surrounding TCR microclusters are essential for T cell activation
Akiko Hashimoto-Tane; Machie Sakuma; Hiroshi Ike; Tadashi Yokosuka; Yayoi Kimura; Osamu Ohara; Takashi Saito
JOURNAL OF EXPERIMENTAL MEDICINE, 213(8), 1609-1625, Jul. 2016, Refereed, Not invited
Lead - Systemic DC Activation Modulates the Tumor Microenvironment and Shapes the Long-Lived Tumor-Specific Memory Mediated by CD8(+) T Cells
Kanako Shimizu; Satoru Yamasaki; Jun Shinga; Yusuke Sato; Takashi Watanabe; Osamu Ohara; Kiyotaka Kuzushima; Hideo Yagita; Yoshiko Komuro; Miki Asakura; Shin-ichiro Fujii
CANCER RESEARCH, 76(13), 3756-3766, Jul. 2016, Refereed, Not invited
Lead - CD4 memory T cells develop and acquire functional competence by sequential cognate interactions and stepwise gene regulation
Tomohiro Kaji; Atsushi Hijikata; Akiko Ishige; Toshimori Kitami; Takashi Watanabe; Osamu Ohara; Noriyuki Yanaka; Mariko Okada; Michiko Shimoda; Masaru Taniguchi; Toshitada Takemori
INTERNATIONAL IMMUNOLOGY, 28(6), 267-282, Jun. 2016, Refereed, Not invited
Lead - Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis
Takuwa Yasuda; Toshiyuki Fukada; Keigo Nishida; Manabu Nakayama; Masashi Matsuda; Ikuo Miura; Teruki Dainichi; Shinji Fukuda; Kenji Kabashima; Shinji Nakaoka; Bum-Ho Bin; Masato Kubo; Hiroshi Ohno; Takanori Hasegawa; Osamu Ohara; Haruhiko Koseki; Shigeharu Wakana; Hisahiro Yoshida
JOURNAL OF CLINICAL INVESTIGATION, 126(6), 2064-2076, Jun. 2016, Refereed, Not invited
Lead - Familial lamin A/C mutation cardiomyopathy with arrhythmia substrate detected by cardiac magnetic resonance imaging and electroanatomical mapping
Takeshi Nishi; Hiroyuki Takaoka; Nobusada Funabashi; Motoi Nishimura; Osamu Ohara; Takeru Makiyama; Marehiko Ueda; Takatsugu Kajiyama; Yoshio Kobayashi
INTERNATIONAL JOURNAL OF CARDIOLOGY, 209, 248-252, Apr. 2016, Refereed, Not invited
Lead - Generation of Novel Traj18-Deficient Mice Lacking V alpha 14 Natural Killer T Cells with an Undisturbed T Cell Receptor alpha-Chain Repertoire
Nyambayar Dashtsoodol; Tomokuni Shigeura; Ritsuko Ozawa; Michishige Harada; Satoshi Kojo; Takashi Watanabe; Haruhiko Koseki; Manabu Nakayama; Osamu Ohara; Masaru Taniguchi
PLOS ONE, 11(4), e0153347, Apr. 2016, Refereed, Not invited
Lead - Exon skipping causes atypical phenotypes associated with a loss-of-function mutation in FLNA by restoring its protein function
Hirotsugu Oda; Tatsuhiro Sato; Shinji Kunishima; Kenji Nakagawa; Kazushi Izawa; Eitaro Hiejima; Tomoki Kawai; Takahiro Yasumi; Hiraku Doi; Kenji Katamura; Hironao Numabe; Shinya Okamoto; Hiroshi Nakase; Atsushi Hijikata; Osamu Ohara; Hidenori Suzuki; Hiroko Morisaki; Takayuki Morisaki; Hiroyuki Nunoi; Seisuke Hattori; Ryuta Nishikomori; Toshio Heike
EUROPEAN JOURNAL OF HUMAN GENETICS, 24(3), 408-414, Mar. 2016, Refereed, Not invited
Lead - Successful reduced-intensity stem cell transplantation for GATA2 deficiency before progression of advanced MDS
Satoshi Saida; Katsutsugu Umeda; Takahiro Yasumi; Akane Matsumoto; Itaru Kato; Hidefumi Hiramatsu; Osamu Ohara; Toshio Heike; Souichi Adachi
PEDIATRIC TRANSPLANTATION, 20(2), 333-336, Mar. 2016, Refereed, Not invited
Lead - Identification of Individual Cancer-Specific Somatic Mutations for Neoantigen-Based Immunotherapy of Lung Cancer
Takahiro Karasaki; Kazuhiro Nagayama; Mitsuaki Kawashima; Noriko Hiyama; Tomonori Murayama; Hideki Kuwano; Jun-ichi Nitadori; Masaki Anraku; Masaaki Sato; Manami Miyai; Akihiro Hosoi; Hirokazu Matsushita; Shingo Kikugawa; Ryo Matoba; Osamu Ohara; Kazuhiro Kakimi; Jun Nakajima
JOURNAL OF THORACIC ONCOLOGY, 11(3), 324-333, Mar. 2016, Refereed, Not invited
Lead - Autoimmunity including intestinal Behçet disease bearing the KRAS mutation in lymphocytes: A case report
Hiroshi Moritake; Masatoshi Takagi; Mariko Kinoshita; Osamu Ohara; Shojiro Yamamoto; Sayaka Moriguchi; Hiroyuki Nunoi
Pediatrics, 137(3), e20152891, Mar. 2016, Refereed, Not invited
Lead - Induction of WT1-specific human CD8(+) T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice
Yuho Najima; Mariko Tomizawa-Murasawa; Yoriko Saito; Takashi Watanabe; Rintaro Ono; Toshiki Ochi; Nahoko Suzuki; Hiroshi Fujiwara; Osamu Ohara; Leonard D. Shultz; Masaki Yasukawa; Fumihiko Ishikawa
BLOOD, 127(6), 722-734, Feb. 2016, Refereed, Not invited
Lead - A Patient with CTLA-4 Haploinsufficiency Presenting Gastric Cancer
Seiichi Hayakawa; Satoshi Okada; Miyuki Tsumura; Sonoko Sakata; Yoshitaka Ueno; Kohsuke Imai; Tomohiro Morio; Osamu Ohara; Kazuaki Chayama; Masao Kobayashi
Journal of Clinical Immunology, 36(1), 28-32, Jan. 2016, Not invited
Lead - A Patient with CTLA-4 Haploinsufficiency Presenting Gastric Cancer
Seiichi Hayakawa; Satoshi Okada; Miyuki Tsumura; Sonoko Sakata; Yoshitaka Ueno; Kohsuke Imai; Tomohiro Morio; Osamu Ohara; Kazuaki Chayama; Masao Kobayashi
JOURNAL OF CLINICAL IMMUNOLOGY, 36(1), 28-32, Jan. 2016, Refereed, Not invited
Lead - RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restricting Meis2 expression
Nayuta Yakushiji-Kaminatsui; Takashi Kondo; Takaho A. Endo; Yoko Koseki; Kaori Kondo; Osamu Ohara; Miguel Vidal; Haruhiko Koseki
DEVELOPMENT, 143(2), 276-285, Jan. 2016, Refereed, Not invited
Lead - Invasive Bacterial Infection in Patients with Interleukin-1 Receptor-associated Kinase 4 Deficiency Case Report
Hidetoshi Takada; Masataka Ishimura; Tomohito Takimoto; Toaki Kohagura; Hideto Yoshikawa; Masue Imaizumi; Koichi Shichijyou; Yoko Shimabukuro; Tomoo Kise; Nobuyuki Hyakuna; Osamu Ohara; Shigeaki Nonoyama; Toshiro Hara
MEDICINE, 95(4), e2437, Jan. 2016, Refereed, Not invited
Lead - XXIV World Allergy Congress 2015: Seoul, Korea. 14-17 October 2015.
Lee H; Park I; Shin J; Yoon H; Park GY; Zeher M; Matsui K; Tamai S; Ikeda R; Suri D; Suri D; Arani MH; Lubis A; Endaryanto A; Koga S; Suk LJ; Tsuzuki Y; Kim SH; Shin JU; Noh JY
2016
Lead - Understanding the role of Interleukin-6 in human immune system
Osamu Ohara
European Journal of Immunology, 2016
Lead - Successful Myeloablative Bone Marrow Transplantation in an Infant With Wiskott-Aldrich Syndrome and Bacillus Calmette-Guerin Infection.
Yasutomi M; Yoshioka K; Mibayashi A; Tanizawa A; Imai K; Ohara O; Ohshima Y
Pediatr Blood Cancer, 62(11), 2052-2053, Nov. 2015, Refereed, Not invited
Lead - Successful Myeloablative Bone Marrow Transplantation in an Infant With Wiskott-Aldrich Syndrome and Bacillus Calmette-Guerin Infection
Motoko Yasutomi; Kikuko Yoshioka; Akihiko Tanizawa; Yusei Ohshima; Akiko Mibayashi; Kohsuke Imai; Osamu Ohara
PEDIATRIC BLOOD & CANCER, 62(11), 2052-2053, Nov. 2015, Refereed, Not invited
Lead - Novel compound heterozygous DNA ligase IV mutations in an adolescent with a slowly-progressing radiosensitive-severe combined immunodeficiency
Shinobu Tamura; Kohei Higuchi; Masaharu Tamaki; Chizuko Inoue; Ryoko Awazawa; Noriko Mitsuki; Yuka Nakazawa; Hiroyuki Mishima; Kenzo Takahashi; Osamu Kondo; Kohsuke Imai; Tomohiro Morio; Osamu Ohara; Tomoo Ogi; Fukumi Furukawa; Masami Inoue; Koh-Ichiro Yoshiura; Nobuo Kanazawa
Clinical Immunology, 160(2), 255-260, Oct. 2015, Not invited
Lead - Role of Bcl-3 in the Development of Follicular Helper T Cells and in the Pathogenesis of Rheumatoid Arthritis
Kazuyuki Meguro; Kotaro Suzuki; Junichi Hosokawa; Yoshie Sanayama; Shigeru Tanaka; Shunsuke Furuta; Kei Ikeda; Hiroaki Takatori; Akira Suto; Akemi Sakamoto; Osamu Ohara; Hiroshi Nakajima
ARTHRITIS & RHEUMATOLOGY, 67(10), 2651-2660, Oct. 2015, Refereed, Not invited
Lead - Novel compound heterozygous DNA ligase IV mutations in an adolescent with a slowly-progressing radiosensitive-severe combined immunodeficiency
Shinobu Tamura; Kohei Higuchi; Masaharu Tamaki; Chizuko Inoue; Ryoko Awazawa; Noriko Mitsuki; Yuka Nakazawa; Hiroyuki Mishima; Kenzo Takahashi; Osamu Kondo; Kohsuke Imai; Tomohiro Mono; Osamu Ohara; Tomoo Ogi; Fukumi Furukawa; Masami Inoue; Koh-Ichiro Yoshiura; Nobuo Kanazawa
CLINICAL IMMUNOLOGY, 160(2), 255-260, Oct. 2015, Refereed, Not invited
Lead - Remarkable improvement of articular pain by biologics in a Multicentric carpotarsal osteolysis patient with a mutation of MAFB gene
Nishikomori R.; Kawai T.; Toshiyuki K.; Oda H.; Yasumi T.; Izawa K.; Ohara O.; Heike T.
Pediatric Rheumatology, 13(1), Sep. 2015
Lead - Laboratory parameters identify familial haemophagocytic lymphohistiocytosis from other forms of paediatric haemophagocytosis
Takahiro Yasumi; Masayuki Hori; Eitaro Hiejima; Hirofumi Shibata; Kazushi Izawa; Hirotsugu Oda; Kouhei Yoshioka; Kenji Nakagawa; Tomoki Kawai; Ryuta Nishikomori; Osamu Ohara; Toshio Heike
BRITISH JOURNAL OF HAEMATOLOGY, 170(4), 532-538, Aug. 2015, Refereed, Not invited
Lead - Idiopathic disseminated bacillus Calmette-Guerin infection in three infants
Jun Kido; Tomoyuki Mizukami; Osamu Ohara; Hidetoshi Takada; Masaaki Yanai
PEDIATRICS INTERNATIONAL, 57(4), 750-753, Aug. 2015, Refereed, Not invited
Lead - CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability
Takeshi Inoue; Masahiro Morita; Atsushi Hijikata; Yoko Fukuda-Yuzawa; Shungo Adachi; Kyoichi Isono; Tomokatsu Ikawa; Hiroshi Kawamoto; Haruhiko Koseki; Tohru Natsume; Taro Fukao; Osamu Ohara; Tadashi Yamamoto; Tomohiro Kurosaki
JOURNAL OF EXPERIMENTAL MEDICINE, 212(9), 1465-1479, Aug. 2015, Refereed, Not invited
Lead - Mosaicism of an ELANE Mutation in an Asymptomatic Mother in a Familial Case of Cyclic Neutropenia
Osamu Hirata; Satoshi Okada; Miyuki Tsumura; Shuhei Karakawa; Itaru Matsumura; Yujiro Kimura; Toshiro Maihara; Shin'ichiro Yasunaga; Yoshihiro Takihara; Osamu Ohara; Masao Kobayashi
JOURNAL OF CLINICAL IMMUNOLOGY, 35(5), 512-516, Jul. 2015, Refereed, Not invited
Lead - Structural and functional analyses of Barth syndrome-causing mutations and alternative splicing in the tafazzin acyltransferase domain
Atsushi Hijikata; Kei Yura; Osamu Ohara; Mitiko Go
Meta Gene, 4, 92-106, Jun. 2015, Refereed, Not invited
Lead - Matrix metalloproteinase 12 is produced by M2 macrophages and plays important roles in the development of contact hypersensitivity
Daiki Nakagomi; Kotaro Suzuki; Kazuyuki Meguro; Junichi Hosokawa; Tomohiro Tamachi; Hiroaki Takatori; Akira Suto; Hiroyuki Matsue; Osamu Ohara; Toshinori Nakayama; Shinji Shimada; Hiroshi Nakajima
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 135(5), 1397-+, May 2015, Refereed, Not invited
Lead - Wiskott-aldrich syndrome in a girl caused by heterozygous WASP mutation and extremely skewed X-chromosome inactivation: A novel association with maternal uniparental isodisomy 6
Tomohito Takimoto; Hidetoshi Takada; Masataka Ishimura; Makiko Kirino; Kenichiro Hata; Osamu Ohara; Tomohiro Morio; Toshiro Hara
Neonatology, 107(3), 185-190, Apr. 2015, Not invited
Lead - RAG1 Deficiency May Present Clinically as Selective IgA Deficiency
Osamu Ohara
Journal of Clinical Immunology, 35(3), 280-288, Apr. 2015, Refereed, Not invited
Lead - RAG1 Deficiency May Present Clinically as Selective IgA Deficiency
Tamaki Kato; Elena Crestani; Chikako Kamae; Kenichi Honma; Tomoko Yokosuka; Takeshi Ikegawa; Naonori Nishida; Hirokazu Kanegane; Taizo Wada; Akihiro Yachie; Osamu Ohara; Tomohiro Morio; Luigi D. Notarangelo; Kohsuke Imai; Shigeaki Nonoyama
Journal of Clinical Immunology, 35(3), 280-288, Mar. 2015, Refereed, Not invited
Lead - X-Linked Agammaglobulinemia Associated with B-Precursor Acute Lymphoblastic Leukemia
Akihiro Hoshino; Yusuke Okuno; Masahiro Migita; Hideki Ban; Xi Yang; Nobutaka Kiyokawa; Yuichi Adachi; Seiji Kojima; Osamu Ohara; Hirokazu Kanegane
Journal of Clinical Immunology, 35(2), 108-111, Mar. 2015, Refereed, Not invited
Lead - Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes.
Kenji Nakagawa; Eva Gonzalez-Roca; Alejandro Souto; Toshinao Kawai; Hiroaki Umebayashi; Josep María Campistol; Jeronima Cañellas; Syuji Takei; Norimoto Kobayashi; Jose Luis Callejas-Rubio; Norberto Ortego-Centeno; Estíbaliz Ruiz-Ortiz; Fina Rius; Jordi Anton; Estibaliz Iglesias; Santiago Jimenez-Treviño; Carmen Vargas; Julian Fernandez-Martin; Inmaculada Calvo; José Hernández-Rodríguez; María Mendez; María Teresa Dordal; Maria Basagaña; Segundo Bujan; Masato Yashiro; Tetsuo Kubota; Ryuji Koike; Naoko Akuta; Kumiko Shimoyama; Naomi Iwata; Megumu K Saito; Osamu Ohara; Naotomo Kambe; Takahiro Yasumi; Kazushi Izawa; Tomoki Kawai; Toshio Heike; Jordi Yagüe; Ryuta Nishikomori; Juan I Aróstegui
Annals of the rheumatic diseases, 74(3), 603-10, Mar. 2015, Not invited
Lead - Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes
Kenji Nakagawa; Eva Gonzalez-Roca; Alejandro Souto; Toshinao Kawai; Hiroaki Umebayashi; Josep Maria Campistol; Jeronima Canellas; Syuji Takei; Norimoto Kobayashi; Jose Luis Callejas-Rubio; Norberto Ortego-Centeno; Estibaliz Ruiz-Ortiz; Fina Rius; Jordi Anton; Estibaliz Iglesias; Santiago Jimenez-Trevino; Carmen Vargas; Julian Fernandez-Martin; Inmaculada Calvo; Jose Hernandez-Rodriguez; Maria Mendez; Maria Teresa Dordal; Maria Basagana; Segundo Bujan; Masato Yashiro; Tetsuo Kubota; Ryuji Koike; Naoko Akuta; Kumiko Shimoyama; Naomi Iwata; Megumu K. Saito; Osamu Ohara; Naotomo Kambe; Takahiro Yasumi; Kazushi Izawa; Tomoki Kawai; Toshio Heike; Jordi Yaguee; Ryuta Nishikomori; Juan I. Arostegui
ANNALS OF THE RHEUMATIC DISEASES, 74(3), 603-610, Mar. 2015, Refereed, Not invited
Lead - Generating a transgenic mouse line stably expressing human MHC surface antigen from a HAC carrying multiple genomic BACs
Yoshinori Hasegawa; Tomoyuki Ishikura; Takanori Hasegawa; Takashi Watanabe; Junpei Suzuki; Manabu Nakayama; Yoshiaki Okamura; Tuneko Okazaki; Haruhiko Koseki; Osamu Ohara; Masashi Ikeno; Hiroshi Masumoto
CHROMOSOMA, 124(1), 107-118, Mar. 2015, Refereed, Not invited
Lead - Mutations in Bruton's tyrosine kinase impair IgA responses
Noriko Mitsuiki; Xi Yang; Sophinus J. W. Bartol; Christina Grosserichter-Wagener; Yoshiyuki Kosaka; Hidetoshi Takada; Kohsuke Imai; Hirokazu Kanegane; Shuki Mizutani; Mirjam van der Burg; Menno C. van Zelm; Osamu Ohara; Tomohiro Morio
INTERNATIONAL JOURNAL OF HEMATOLOGY, 101(3), 305-313, Mar. 2015, Refereed, Not invited
Lead - Identification of CD34+ and CD34- Leukemia-initiating cells in MLL-rearranged human acute lymphoblastic Leukemia
Yuki Aoki; Takashi Watanabe; Yoriko Saito; Yoko Kuroki; Atsushi Hijikata; Masatoshi Takagi; Daisuke Tomizawa; Mariko Eguchi; Minenori Eguchi-Ishimae; Akiko Kaneko; Rintaro Ono; Kaori Sato; Nahoko Suzuki; Saera Fujiki; Katsuyoshi Koh; Eiichi Ishii; Leonard D. Shultz; Osamu Ohara; Shuki Mizutani; Fumihiko Ishikawa
Blood, 125(6), 967-980, Feb. 2015, Not invited
Lead - Identification of CD34(+) and CD34(-) leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia
Yuki Aoki; Takashi Watanabe; Yoriko Saito; Yoko Kuroki; Atsushi Hijikata; Masatoshi Takagi; Daisuke Tomizawa; Mariko Eguchi; Minenori Eguchi-Ishimae; Akiko Kaneko; Rintaro Ono; Kaori Sato; Nahoko Suzuki; Saera Fujiki; Katsuyoshi Koh; Eiichi Ishii; Leonard D. Shultz; Osamu Ohara; Shuki Mizutani; Fumihiko Ishikawa
BLOOD, 125(6), 967-980, Feb. 2015, Refereed, Not invited
Lead - X-Linked Agammaglobulinemia Associated with B-Precursor Acute Lymphoblastic Leukemia
Akihiro Hoshino; Yusuke Okuno; Masahiro Migita; Hideki Ban; Xi Yang; Nobutaka Kiyokawa; Yuichi Adachi; Seiji Kojima; Osamu Ohara; Hirokazu Kanegane
JOURNAL OF CLINICAL IMMUNOLOGY, 35(2), 108-111, Feb. 2015, Refereed, Not invited
Lead - Cytotoxic T Lymphocytes Block Tumor Growth Both by Lytic Activity and IFN gamma-Dependent Cell-Cycle Arrest
Hirokazu Matsushita; Akihiro Hosoi; Satoshi Ueha; Jun Abe; Nao Fujieda; Michio Tomura; Ryuji Maekawa; Kouji Matsushima; Osamu Ohara; Kazuhiro Kakimi
CANCER IMMUNOLOGY RESEARCH, 3(1), 26-36, Jan. 2015, Refereed, Not invited
Lead - Enhanced Chondrogenesis of Induced Pluripotent Stem Cells From Patients With Neonatal-Onset Multisystem Inflammatory Disease Occurs via the Caspase 1-Independent cAMP/Protein Kinase A/CREB Pathway
Koji Yokoyama; Makoto Ikeya; Katsutsugu Umeda; Hirotsugu Oda; Seishiro Nodomi; Akira Nasu; Yoshihisa Matsumoto; Kazushi Izawa; Kazuhiko Horigome; Toshimasa Kusaka; Takayuki Tanaka; Megumu K. Saito; Takahiro Yasumi; Ryuta Nishikomori; Osamu Ohara; Naoki Nakayama; Tatsutoshi Nakahata; Toshio Heike; Junya Toguchida
ARTHRITIS & RHEUMATOLOGY, 67(1), 302-314, Jan. 2015, Refereed, Not invited
Lead - Atypical giant axonal neuropathy arising from a homozygous mutation by uniparental isodisomy
S. Miyatake; H. Tada; S. Moriya; J. Takanashi; Y. Hirano; M. Hayashi; Y. Oya; M. Nakashima; Y. Tsurusaki; N. Miyake; N. Matsumoto; H. Saitsu
Clinical Genetics, 87(4), 395-397, 2015
Lead - Qualitative change monitoring of heterogeneous nuclear ribonucleoprotein K
木村弥生; 井野洋子; 戸田年総; 平野久; 小原收
電気泳動(Web), 59(2), 79-81 (J-STAGE)-81, 2015, Refereed, Not invited
Lead - Merkel Cell Polyomavirus-positive Merkel Cell Carcinoma in a Patient with Epidermodysplasia Verruciformis
Yuki Mizuno; Genichi Kato; En Shu; Hidenori Ohnishi; Toshiyuki Fukao; Osamu Ohara; Hitomi Fukumoto; Harutaka Katano; Mariko Seishima
ACTA DERMATO-VENEREOLOGICA, 95(1), 98-99, 2015, Refereed, Not invited
Lead - Wiskott-Aldrich Syndrome in a Girl Caused by Heterozygous WASP Mutation and Extremely Skewed X-Chromosome Inactivation: A Novel Association with Maternal Uniparental Isodisomy 6
Tonnohito Takinnoto; Hidetoshi Takada; Masataka Ishimura; Makiko Kirino; Kenichiro Hata; Osamu Ohara; Tomohiro Morio; Toshiro Hara
NEONATOLOGY, 107(3), 185-190, 2015, Refereed, Not invited
Lead - CTLs regulate tumor growth via cytostatic effects rather than cytotoxicity: A few T cells can influence the growth of many times more tumor cells
Kazuhiro Kakimi; Hirokazu Matsushita; Akihiro Hosoi; Manami Miyai; Osamu Ohara
OncoImmunology, 4(3), 1-3, 2015, Refereed, Not invited
Lead - Analysis of Mutations in the IL2RG Gene in 2 Asian Infants With X-linked Severe Combined Immunodeficiency
Y. Hara; N. Kobayashi; Y. Maruyama; M. Motobayashi; Shigemura Tl; O. Ohara; K. Agematsu; K. Koike
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY, 25(4), 313-315, 2015, Refereed, Not invited
Lead - Reply: To PMID 24591094.
Yoshie Sanayama; Kei Ikeda; Mieko Yamagata; Shunsuke Furuta; Osamu Ohara; Hiroshi Nakajima
Arthritis & rheumatology (Hoboken, N.J.), 66(12), 3524-5, Dec. 2014
Lead - Hyper-IgE syndrome with a novel STAT3 mutation-a single center study from India
Biman Saikia; Deepti Suri; Shubham Goel; Amit Rawat; Ranjana W. Minz; Anju Gupta; Sudha Sharma; Osamu Ohara; Kohsuke Imai; Shigeaki Nonoyama; Shobha Sehgal; Surjit Singh
ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, 32(4), 321-327, Dec. 2014, Refereed, Not invited
Lead - A novel mucosal vaccine targeting Peyer's patch M cells induces protective antigen-specific IgA responses
Hideaki Shima; Takashi Watanabe; Shinji Fukuda; Shin-Ichi Fukuoka; Osamu Ohara; Hiroshi Ohno
INTERNATIONAL IMMUNOLOGY, 26(11), 619-625, Nov. 2014, Refereed, Not invited
Lead - 間質性肺野病変で発症しDermatopathic Lymphadenitisと診断された慢性肉芽腫症の男児例(Chronic granulomatous disease diagnosed as Dermatopathic lymphadenitis initially presented with diffuse pulmonary infiltration)
鬼頭 敏幸; 山口 悦郎; 藤井 公人; 高橋 恵美子; 小田 紘嗣; 小原 収; 金兼 弘和
日本小児血液・がん学会雑誌, 51(4), 290-290, Oct. 2014, Refereed, Not invited
Lead - IL-17RA Deficiency Underlying Chronic Mucocutaneous Disease (CMCD): Genetic and Clinical Features in 7 Patients from Turkey and Japan
R. Levy; S. Okada; Y. Camcioglu; J. Toubiana; N. Hyakuna; M. Migaud; A. Takaki; O. Ohara; M. Kobayashi; J. L. Casanova; A. Puel
JOURNAL OF CLINICAL IMMUNOLOGY, 34, S174-S175, Oct. 2014, Refereed, Not invited
Lead - Circulating AIM Prevents Hepatocellular Carcinoma through Complement Activation
Natsumi Maehara; Satoko Arai; Mayumi Mori; Yoshihiro Iwamura; Jun Kurokawa; Toshihiro Kai; Shunsuke Kusunoki; Kaori Taniguchi; Kazutaka Ikeda; Osamu Ohara; Ken-ichi Yamamura; Toru Miyazaki
CELL REPORTS, 9(1), 61-74, Oct. 2014, Refereed, Not invited
Lead - A Complement Factor B Mutation in a Large Kindred with Atypical Hemolytic Uremic Syndrome
Michinori Funato; Osamu Uemura; Katsumi Ushijima; Hidenori Ohnishi; Kenji Orii; Zenichiro Kato; Satoshi Yamakawa; Takuhito Nagai; Osamu Ohara; Hideo Kaneko; Naomi Kondo
JOURNAL OF CLINICAL IMMUNOLOGY, 34(6), 691-695, Aug. 2014, Refereed, Not invited
Lead - Sox5 and c-Maf cooperatively induce Th17 cell differentiation via ROR gamma t induction as downstream targets of Stat3
Shigeru Tanaka; Akira Suto; Taro Iwamoto; Daisuke Kashiwakuma; Shin-ichiro Kagami; Kotaro Suzuki; Hiroaki Takatori; Tomohiro Tamachi; Koichi Hirose; Atsushi Onodera; Junpei Suzuki; Osamu Ohara; Masakatsu Yamashita; Toshinori Nakayama; Hiroshi Nakajima
JOURNAL OF EXPERIMENTAL MEDICINE, 211(9), 1857-1874, Aug. 2014, Refereed, Not invited
Lead - Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development
Tomohiro Miyai; Shintaro Hojyo; Tomokatsu Ikawa; Masami Kawamura; Tarou Irie; Hideki Ogura; Atsushi Hijikata; Bum-Ho Bin; Takuwa Yasuda; Hiroshi Kitamura; Manabu Nakayama; Osamu Ohara; Hisahiro Yoshida; Haruhiko Koseki; Kenji Mishima; Toshiyuki Fukada
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(32), 11780-11785, Aug. 2014, Refereed, Not invited
Lead - Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength
Shintaro Hojyo; Tomohiro Miyai; Hitomi Fujishiro; Masami Kawamura; Takuwa Yasuda; Atsushi Hijikata; Bum-Ho Bin; Tarou Irie; Junichi Tanaka; Toru Atsumi; Masaaki Murakami; Manabu Nakayama; Osamu Ohara; Seiichiro Himeno; Hisahiro Yoshida; Haruhiko Koseki; Tomokatsu Ikawa; Kenji Mishima; Toshiyuki Fukada
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(32), 11786-11791, Aug. 2014, Refereed, Not invited
Lead - KLRG(+) invariant natural killer T cells are long-lived effectors
Kanako Shimizu; Yusuke Sato; Jun Shinga; Takashi Watanabe; Takaho Endo; Miki Asakura; Satoru Yamasaki; Kazuyoshi Kawahara; Yuki Kinjo; Hiroshi Kitamura; Hiroshi Watarai; Yasuyuki Ishii; Moriya Tsuji; Masaru Taniguchi; Osamu Ohara; Shin-Ichiro Fujii
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(34), 12474-12479, Aug. 2014, Refereed, Not invited
Lead - Single-Cell Imaging of Caspase-1 Dynamics Reveals an All-or-None Inflammasome Signaling Response
Ting Liu; Yoshifumi Yamaguchi; Yoshitaka Shirasaki; Koichi Shikada; Mai Yamagishi; Katsuaki Hoshino; Tsuneyasu Kaisho; Kiwamu Takemoto; Toshihiko Suzuki; Erina Kuranaga; Osamu Ohara; Masayuki Miura
CELL REPORTS, 8(4), 974-982, Aug. 2014, Refereed, Not invited
Lead - Mammalian Polycomb-Like Pcl2/Mtf2 Is a Novel Regulatory Component of PRC2 That Can Differentially Modulate Polycomb Activity both at the Hox Gene Cluster and at Cdkn2a Genes (vol 31, pg 351, 2011)
Xiangzhi Li; Kyo-ichi Isono; Daisuke Yamada; Takaho A. Endo; Mitsuhiro Endoh; Jun Shinga; Yoko Mizutani-Koseki; Arie P. Otte; Miguel Casanova; Hiroshi Kitamura; Takehiko Kamijo; Jafar Sharif; Osamu Ohara; Tetsuro Toyada; Bradley E. Bernstein; Neil Brockdorff; Haruhiko Koseki
MOLECULAR AND CELLULAR BIOLOGY, 34(14), 2773-2773, Jul. 2014, Refereed, Not invited
Lead - Clinical and Genetic Characterization of Japanese Sporadic Cases of Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis Syndrome from a Single Medical Center in Japan
Kazuo Kubota; Hidenori Ohnishi; Takahide Teramoto; Norio Kawamoto; Kimiko Kasahara; Osamu Ohara; Naomi Kondo
JOURNAL OF CLINICAL IMMUNOLOGY, 34(5), 584-593, Jul. 2014, Refereed, Not invited
Lead - Clinical characteristics and genetic analysis of childhood acute lymphoblastic leukemia with hemophagocytic lymphohistiocytosis: a Japanese retrospective study by the Kyushu-Yamaguchi Children's Cancer Study Group
Hiroshi Moritake; Sachiyo Kamimura; Hiroyuki Nunoi; Hideki Nakayama; Aiko Suminoe; Hiroko Inada; Jiro Inagaki; Fumio Yanai; Yasuhiro Okamoto; Yuichi Shinkoda; Maiko Shimomura; Nobuyoshi Itonaga; Noriko Hotta; Yasufumi Hidaka; Osamu Ohara; Masakatsu Yanagimachi; Noriko Nakajima; Jun Okamura; Yoshifumi Kawano
INTERNATIONAL JOURNAL OF HEMATOLOGY, 100(1), 70-78, Jul. 2014, Refereed, Not invited
Lead - Aicardi-Goutieres Syndrome Is Caused by IFIH1 Mutations
Hirotsugu Oda; Kenji Nakagawa; Junya Abe; Tomonari Awaya; Masahide Funabiki; Atsushi Hijikata; Ryuta Nishikomori; Makoto Funatsuka; Yusei Ohshima; Yuji Sugawara; Takahiro Yasumi; Hiroki Kato; Tsuyoshi Shirai; Osamu Ohara; Takashi Fujita; Toshio Heike
AMERICAN JOURNAL OF HUMAN GENETICS, 95(1), 121-125, Jul. 2014, Refereed, Not invited
Lead - Two novel HSD3B2 missense mutations with diverse residual enzymatic activities for Delta 5-steroids
Kei Takasawa; Makoto Ono; Atsushi Hijikata; Yohei Matsubara; Noriyuki Katsumata; Masatoshi Takagi; Tomohiro Morio; Osamu Ohara; Kenichi Kashimada; Shuki Mizutani
CLINICAL ENDOCRINOLOGY, 80(6), 782-789, Jun. 2014, Refereed, Not invited
Lead - Prediction of Therapeutic Responses to Tocilizumab in Patients With Rheumatoid Arthritis Biomarkers Identified by Analysis of Gene Expression in Peripheral Blood Mononuclear Cells Using Genome-Wide DNA Microarray
Yoshie Sanayama; Kei Ikeda; Yukari Saito; Shin-ichiro Kagami; Mieko Yamagata; Shunsuke Furuta; Daisuke Kashiwakuma; Itsuo Iwamoto; Takeshi Umibe; Yasushi Nawata; Ryutaro Matsumura; Takao Sugiyama; Makoto Sueishi; Masaki Hiraguri; Ken Nonaka; Osamu Ohara; Hiroshi Nakajima
ARTHRITIS & RHEUMATOLOGY, 66(6), 1421-1431, Jun. 2014, Refereed, Not invited
Lead - The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells
Yuuki Obata; Yukihiro Furusawa; Takaho A. Endo; Jafar Sharif; Daisuke Takahashi; Koji Atarashi; Manabu Nakayama; Satoshi Onawa; Yumiko Fujimura; Masumi Takahashi; Tomokatsu Ikawa; Takeshi Otsubo; Yuki I. Kawamura; Taeko Dohi; Shoji Tajima; Hiroshi Masumoto; Osamu Ohara; Kenya Honda; Shohei Hori; Hiroshi Ohno; Haruhiko Koseki; Koji Hase
NATURE IMMUNOLOGY, 15(6), 571-579, Jun. 2014, Refereed, Not invited
Lead - Clinical and mutational features of Vietnamese children with X-linked agammaglobulinemia
Quang Van Vu; Taizo Wada; Huong Thi Minh Le; Hai Thanh Le; Anh Thi Van Nguyen; Ohara Osamu; Akihiro Yachie; Sang Ngoc Nguyen
BMC PEDIATRICS, 14, May 2014, Refereed, Not invited
Lead - AT-Rich-Interactive Domain-Containing Protein 5A Functions as a Negative Regulator of Retinoic Acid Receptor-Related Orphan Nuclear Receptor gamma t-Induced Th17 Cell Differentiation
Yukari Saito; Shin-ichiro Kagami; Yoshie Sanayama; Kei Ikeda; Akira Suto; Daisuke Kashiwakuma; Shunsuke Furuta; Itsuo Iwamoto; Ken Nonaka; Osamu Ohara; Hiroshi Nakajima
ARTHRITIS & RHEUMATOLOGY, 66(5), 1185-1194, May 2014, Refereed, Not invited
Lead - Basophil-Derived Interleukin-4 Controls the Function of Natural Helper Cells, a Member of ILC2s, in Lung Inflammation
Yasutaka Motomura; Hideaki Morita; Kazuyo Moro; Susumu Nakae; David Artis; Takaho A. Endo; Yoko Kuroki; Osamu Ohara; Shigeo Koyasu; Masato Kubo
IMMUNITY, 40(5), 758-771, May 2014, Refereed, Not invited
Lead - The Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis
Makoto Kuwahara; Junpei Suzuki; Soichi Tofukuji; Takeshi Yamada; Makoto Kanoh; Akira Matsumoto; Saho Maruyama; Kohei Kometani; Tomohiro Kurosaki; Osamu Ohara; Toshinori Nakayama; Masakatsu Yamashita
NATURE COMMUNICATIONS, 5, 3555, Apr. 2014, Refereed, Not invited
Lead - Real-time single-cell imaging of protein secretion
Yoshitaka Shirasaki; Mai Yamagishi; Nobutake Suzuki; Kazushi Izawa; Asahi Nakahara; Jun Mizuno; Shuichi Shoji; Toshio Heike; Yoshie Harada; Ryuta Nishikomori; Osamu Ohara
SCIENTIFIC REPORTS, 4, 4736, Apr. 2014, Refereed, Not invited
Lead - A nationwide survey of Aicardi-Goutieres syndrome patients identifies a strong association between dominant TREX1 mutations and chilblain lesions: Japanese cohort study
Junya Abe; Kazuyuki Nakamura; Ryuta Nishikomori; Mitsuhiro Kato; Noriko Mitsuiki; Kazushi Izawa; Tomonari Awaya; Tomoki Kawai; Takahiro Yasumi; Itaru Toyoshima; Kazuko Hasegawa; Yusei Ohshima; Toru Hiragi; Yoji Sasahara; Yasuhiro Suzuki; Masahiro Kikuchi; Hitoshi Osaka; Takashi Ohya; Shinya Ninomiya; Satoshi Fujikawa; Manami Akasaka; Naomi Iwata; Akiko Kawakita; Makoto Funatsuka; Haruo Shintaku; Osamu Ohara; Hiroshi Ichinose; Toshio Heike
RHEUMATOLOGY, 53(3), 448-458, Mar. 2014, Refereed, Not invited
Lead - Erratum: Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells (Nature (2013) 504 (446-450) DOI: 10.1038/nature12721)
Furusawa, Y.; Obata, Y.; Fukuda, S.; Endo, T.A.; Nakato, G.; Takahashi, D.; Nakanishi, Y.; Uetake, C.; Kato, K.; Kato, T.; Takahashi, M.; Fukuda, N.N.; Murakami, S.; Miyauchi, E.; Hino, S.; Atarashi, K.; Onawa, S.; Fujimura, Y.; Lockett, T.; Clarke, J.M.; Topping, D.L.; Tomita, M.; Hori, S.; Ohara, O.; Morita, T.; Koseki, H.; Kikuchi, J.; Honda, K.; Hase, K.; Ohno, H.
Nature, 506(7487), Feb. 2014, Not invited
Lead - Prebiotic consumption in pregnant and lactating women increases IL-27 expression in human milk
Takayuki Kubota; Naoki Shimojo; Ken Nonaka; Masakatsu Yamashita; Osamu Ohara; Yuka Igoshi; Naoko Ozawa; Taiji Nakano; Yoshinori Morita; Yuzaburo Inoue; Takayasu Arima; Kohki Chiba; Yoshitaka Nakamura; Shuji Ikegami; Kentaro Masuda; Shuichi Suzuki; Yoichi Kohno
BRITISH JOURNAL OF NUTRITION, 111(4), 625-632, Feb. 2014, Refereed, Not invited
Lead - Chronic Granulomatous Disease: Two Decades of Experience From a Tertiary Care Centre in North West India
Amit Rawat; Surjit Singh; Deepti Suri; Anju Gupta; Biman Saikia; Ranjana Walker Minz; Shobha Sehgal; Kim Vaiphei; C. Kamae; K. Honma; N. Nakagawa; K. Imai; S. Nonoyama; K. Oshima; N. Mitsuiki; O. Ohara; Koon-Wing Chan; Yu Lung Lau
JOURNAL OF CLINICAL IMMUNOLOGY, 34(1), 58-67, Jan. 2014, Refereed, Not invited
Lead - High-throughput single-cell secretion measurement on an optical wavegude chip
Y. Shirasaki; N. Suzuki; M. Yamagishi; A. Nakahara; S. Shoji; O. Ohara
18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, 831-833, 2014
Lead - Identifying biomarkers: where is the scientific methodology? Comment on the article by Sanayama et al Reply
Osamu Ohara
Arthritis & Rheumatology, 2014
Lead - 1P306 Analysis of non-classical secretion of IL-1β using real-time single-cell secretion imaging(27. Bioimaging,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014))
Shirasaki Yoshitaka; Liu Ting; Yamaguchi Yoshifumi; Yamaguchi Mai; Suzuki Nobutake; Izawa Kazushi; Mizuno Jun; Shoji Shuichi; Harada Yoshie; Nishikomori Ryuta; Heike Toshio; Miura Masayuki; Ohara Osamu
Seibutsu Butsuri, 54(1), S191, 2014
Lead - Two novel HSD3B2 missense mutations with diverse residual enzymatic activities for Δ5-steroids
Kei Takasawa; Makoto Ono; Atsushi Hijikata; Yohei Matsubara; Noriyuki Katsumata; Masatoshi Takagi; Tomohiro Morio; Osamu Ohara; Kenichi Kashimada; Shuki Mizutani
Clinical Endocrinology, 80(6), 782-789, 2014, Refereed, Not invited
Lead - Multiple omics uncovers host-gut microbial mutualism during prebiotic fructooligosaccharide supplementation
Kato Tamotsu; Fukuda Shinji; Fujiwara Akemi; Suda Wataru; Hattori Masahira; Kikuchi Jun; Ohno Hiroshi; Osamu Ohara
DNA Research, 21(5), 469-480, 2014, Refereed, Not invited
Lead - Mutations in Bruton's Tyrosine Kinase Impair IgA Responses
Osamu Ohara
Journal of Clinical Immunology, 101(3), 305-313, 2014, Refereed, Not invited
Lead - Clinical characteristics and genetic analysis of childhood acute lymphoblastic leukemia with hemophagocytic lymphohistiocytosis: A Japanese retrospective study by the Kyushu-Yamaguchi Children's Cancer Study Group
Hiroshi Moritake; Sachiyo Kamimura; Hiroyuki Nunoi; Hideki Nakayama; Aiko Suminoe; Hiroko Inada; Jiro Inagaki; Fumio Yanai; Yasuhiro Okamoto; Yuichi Shinkoda; Maiko Shimomura; Nobuyoshi Itonaga; Noriko Hotta; Yasufumi Hidaka; Osamu Ohara; Masakatsu Yanagimachi; Noriko Nakajima; Jun Okamura; Yoshifumi Kawano
International Journal of Hematology, 100(1), 70-78, 2014, Refereed, Not invited
Lead - Clinical and genetic characterization of Japanese sporadic cases of periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome from a single medical center in Japan
Kazuo Kubota; Hidenori Ohnishi; Takahide Teramoto; Norio Kawamoto; Kimiko Kasahara; Osamu Ohara; Naomi Kondo
Journal of Clinical Immunology, 34(5), 584-593, 2014, Refereed, Not invited
Lead - Successful Treatment of Systemic Cytomegalovirus Infection in Severe Combined Immunodeficiency Using Allogeneic Bone Marrow Transplantation Followed by Adoptive Immunotherapy
U. Koura; H. Sakaki-Nakatsubo; K. Otsubo; K. Nomura; K. Oshima; O. Ohara; T. Wada; A. Yachie; K. Imai; T. Morio; T. Miyawaki; H. Kanegane
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY, 24(3), 200-202, 2014, Refereed, Not invited
Lead - Pitfalls in global normalization of ChIP-seq data in CD4+ T cells treated with butyrate: A possible solution strategy
Yukihiro Furusawa; Takaho A. Endo; Yuuki Obata; Osamu Ohara; Hiroshi Ohno; Koji Hase
Genomics Data, 2, 176-180, 2014, Refereed, Not invited
Lead - Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells.
Yukihiro Furusawa; Yuuki Obata; Shinji Fukuda; Takaho A Endo; Gaku Nakato; Daisuke Takahashi; Yumiko Nakanishi; Chikako Uetake; Keiko Kato; Tamotsu Kato; Masumi Takahashi; Noriko N Fukuda; Shinnosuke Murakami; Eiji Miyauchi; Shingo Hino; Koji Atarashi; Satoshi Onawa; Yumiko Fujimura; Trevor Lockett; Julie M Clarke; David L Topping; Masaru Tomita; Shohei Hori; Osamu Ohara; Tatsuya Morita; Haruhiko Koseki; Jun Kikuchi; Kenya Honda; Koji Hase; Hiroshi Ohno
Nature, 504(7480), 446-50, Dec. 2013, Refereed, Not invited
Lead - Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation
Hiroshi Kitamura; Shunsuke Kimura; Yoshinori Shimamoto; Jun Okabe; Masatoshi Ito; Tomomi Miyamoto; Yoshinori Naoe; Chisato Kikuguchi; Bob Meek; Chitoku Toda; Shiki Okamoto; Katsushi Kanehira; Koji Hase; Hiroshi Watarai; Mayumi Ishizuka; Assam El-Osta; Osamu Ohara; Ichiro Miyoshi
FASEB Journal, 27(12), 4940-4953, Dec. 2013, Refereed, Not invited
Lead - Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation
Hiroshi Kitamura; Shunsuke Kimura; Yoshinori Shimamoto; Jun Okabe; Masatoshi Ito; Tomomi Miyamoto; Yoshinori Naoe; Chisato Kikuguchi; Bob Meek; Chitoku Toda; Shiki Okamoto; Katsushi Kanehira; Koji Hase; Hiroshi Watarai; Mayumi Ishizuka; Assam El-Osta; Osamu Ohara; Ichiro Miyoshi
FASEB JOURNAL, 27(12), 4940-4953, Dec. 2013, Refereed, Not invited
Lead - BTK異変をみとめたIgA単独欠損の解析
満生 紀子; 今井 耕輔; Yang Xi; 金兼 弘和; 小阪 嘉之; 高田 英俊; 水谷 修紀; 小原 収; 森尾 友宏
日本臨床免疫学会会誌, 36(5), 389-389, Oct. 2013, Refereed, Not invited
Lead - The identification of a novel splicing mutation in C1qB in a Japanese family with C1q deficiency: a case report
Yousuke Higuchi; Junya Shimizu; Michiyo Hatanaka; Etsuko Kitano; Hajime Kitamura; Hidetoshi Takada; Masataka Ishimura; Toshiro Hara; Osamu Ohara; Kenji Asagoe; Toshihide Kubo
PEDIATRIC RHEUMATOLOGY, 11(1), 41, Oct. 2013, Refereed, Not invited
Lead - Mouse cloning using a drop of peripheral blood.
Satoshi Kamimura; Kimiko Inoue; Narumi Ogonuki; Michiko Hirose; Mami Oikawa; Masahiro Yo; Osamu Ohara; Hiroyuki Miyoshi; Atsuo Ogura
Biology of reproduction, 89(2), 24-24, Aug. 2013, Refereed, Not invited
Lead - The FLS (Fatty liver Shionogi) mouse reveals local expressions of lipocalin-2, CXCL1 and CXCL9 in the liver with non-alcoholic steatohepatitis
Toshihisa Semba; Motoi Nishimura; Satomi Nishimura; Osamu Ohara; Takayuki Ishige; Sayaka Ohno; Ken Nonaka; Kazuyuki Sogawa; Mamoru Satoh; Setsu Sawai; Kazuyuki Matsushita; Fumio Imazeki; Osamu Yokosuka; Fumio Nomura
BMC Gastroenterology, 13(1), 120, Jul. 2013, Refereed, Not invited
Lead - Embracing change to remain the same: conservation of polycomb functions despite divergence of binding motifs among species
Jafar Sharif; Takaho A. Endo; Shinsuke Ito; Osamu Ohara; Haruhiko Koseki
CURRENT OPINION IN CELL BIOLOGY, 25(3), 305-313, Jun. 2013, Refereed, Not invited
Lead - Rapid detection of intracellular p47phox and p67phox by flow cytometry; Useful screening tests for chronic granulomatous disease
Taizo Wada; Masahiro Muraoka; Tomoko Toma; Tsuyoshi Imai; Tomonari Shigemura; Kazunaga Agematsu; Kohei Haraguchi; Hiroyuki Moriuchi; Tsutomu Oh-Ishi; Toshiyuki Kitoh; Osamu Ohara; Tomohiro Morio; Akihiro Yachie
Journal of Clinical Immunology, 33(4), 857-864, May 2013, Refereed, Not invited
Lead - Common variable immunodeficiency classification by quantifying T-cell receptor and immunoglobulin κ-deleting recombination excision circles
Chikako Kamae; Noriko Nakagawa; Hiroki Sato; Kenichi Honma; Noriko Mitsuiki; Osamu Ohara; Hirokazu Kanegane; Srdjan Pasic; Qiang Pan-Hammarström; Menno C. Van Zelm; Tomohiro Morio; Kohsuke Imai; Shigeaki Nonoyama
Journal of Allergy and Clinical Immunology, 131(5), 1437-1440, May 2013, Refereed, Not invited
Lead - Common variable immunodeficiency classification by quantifying T-cell receptor and immunoglobulin kappa-deleting recombination excision circles
Chikako Kamae; Noriko Nakagawa; Hiroki Sato; Kenichi Honma; Noriko Mitsuiki; Osamu Ohara; Hirokazu Kanegane; Srdjan Pasic; Qiang Pan-Hammarstrom; Menno C. van Zelm; Tomohiro Morio; Kohsuke Imai; Shigeaki Nonoyama
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 131(5), 1437-+, May 2013, Refereed, Not invited
Lead - Rapid Detection of Intracellular p47phox and p67phox by Flow Cytometry; Useful Screening Tests for Chronic Granulomatous Disease
Taizo Wada; Masahiro Muraoka; Tomoko Toma; Tsuyoshi Imai; Tomonari Shigemura; Kazunaga Agematsu; Kohei Haraguchi; Hiroyuki Moriuchi; Tsutomu Oh-ishi; Toshiyuki Kitoh; Osamu Ohara; Tomohiro Morio; Akihiro Yachie
JOURNAL OF CLINICAL IMMUNOLOGY, 33(4), 857-864, May 2013, Refereed, Not invited
Lead - PAD4 regulates proliferation of multipotent haematopoietic cells by controlling c-myc expression
Katsuhiko Nakashima; Satoko Arai; Akari Suzuki; Yuko Nariai; Takeshi Urano; Manabu Nakayama; Osamu Ohara; Ken-ichi Yamamura; Kazuhiko Yamamoto; Toru Miyazaki
NATURE COMMUNICATIONS, 4, 1836, May 2013, Refereed, Not invited
Lead - A Novel Small Compound SH-2251 Suppresses Th2 Cell-Dependent Airway Inflammation through Selective Modulation of Chromatin Status at the Il5 Gene Locus
Junpei Suzuki; Makoto Kuwahara; Soichi Tofukuji; Masashi Imamura; Fuminori Kato; Toshinori Nakayama; Osamu Ohara; Masakatsu Yamashita
PLoS ONE, 8(4), e61785, Apr. 2013, Refereed, Not invited
Lead - Obesity-Associated Autoantibody Production Requires AIM to Retain the Immunoglobulin M Immune Complex on Follicular Dendritic Cells
Satoko Arai; Natsumi Maehara; Yoshihiro Iwamura; Shin-ichiro Honda; Katsuhiko Nakashima; Toshihiro Kai; Masato Ogishi; Kumiko Morita; Jun Kurokawa; Mayumi Mori; Yuji Motoi; Kensuke Miyake; Nobuyuki Matsuhashi; Ken-ichi Yamamura; Osamu Ohara; Akira Shibuya; Edward K. Wakeland; Quan-Zhen Li; Toru Miyazaki
CELL REPORTS, 3(4), 1187-1198, Apr. 2013, Refereed, Not invited
Lead - A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo
Yoriko Saito; Hitomi Yuki; Mitsuo Kuratani; Yoshinobu Hashizume; Shinsuke Takagi; Teruki Honma; Akiko Tanaka; Mikako Shirouzu; Junko Mikuni; Noriko Handa; Ikuko Ogahara; Akiko Sone; Yuho Najima; Yuri Tomabechi; Motoaki Wakiyama; Naoyuki Uchida; Mariko Tomizawa-Murasawa; Akiko Kaneko; Satoshi Tanaka; Nahoko Suzuki; Hiroshi Kajita; Yuki Aoki; Osamu Ohara; Leonard D. Shultz; Takehiro Fukami; Toshio Goto; Shuichi Taniguchi; Shigeyuki Yokoyama; Fumihiko Ishikawa
SCIENCE TRANSLATIONAL MEDICINE, 5(181), 181ra52, Apr. 2013, Refereed, Not invited
Lead - A novel Wiskott-Aldrich syndrome protein mutation in an infant with thrombotic thrombocytopenic purpura
Yukako Kawasaki; Hidemi Toyoda; Shoichiro Otsuki; Tadashi Iwasa; Shotaro Iwamoto; Eiichi Azuma; Naomi Itoh-Habe; Hideo Wada; Yoshihiro Fujimura; Tomohiro Morio; Kohsuke Imai; Noriko Mitsuiki; Osamu Ohara; Yoshihiro Komada
European Journal of Haematology, 90(2), 164-168, Feb. 2013, Refereed, Not invited
Lead - A novel Wiskott-Aldrich syndrome protein mutation in an infant with thrombotic thrombocytopenic purpura
Yukako Kawasaki; Hidemi Toyoda; Shoichiro Otsuki; Tadashi Iwasa; Shotaro Iwamoto; Eiichi Azuma; Naomi Itoh-Habe; Hideo Wada; Yoshihiro Fujimura; Tomohiro Morio; Kohsuke Imai; Noriko Mitsuiki; Osamu Ohara; Yoshihiro Komada
EUROPEAN JOURNAL OF HAEMATOLOGY, 90(2), 164-168, Feb. 2013, Refereed, Not invited
Lead - Toward an understanding of immune cell sociology: real-time monitoring of cytokine secretion at the single-cell level
Yoshitaka Shirasaki; Mai Yamagishi; Nanako Shimura; Atsushi Hijikata; Osamu Ohara
IUBMB LIFE, 65(1), 28-34, Jan. 2013, Refereed, Not invited
Lead - PW02-029 - Single cell fluorescent immunoassay of CINCA/NOMID.
Nakagawa K; Shimura N; Shirasaki Y; Yamagishi M; Izawa K; Nishikomori R; Kawai T; Yasumi T; Heike T; Ohara O
2013
Lead - P03-023 – Autoinflammatory diseases database in Japan.
Kawai T; Nishikomori R; Awaya M; Nakagawa K; Izawa K; Yasumi T; Ohara O; Heike T
2013
Lead - Real-time secretion analysis revealed correlation of IL-1β release and loss of cell membrane integrity
Y. Shirasaki; M. Yamagishi; K. Izawa; K. Nakagawa; A. Nakahara; N. Suzuki; J. Mizuno; T. Sekiguchi; T. Heike; R. Nishikomori; S. Shoji; O. Ohara
17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, 3, 1686-1688, 2013
Lead - P4-07 BTK変異をみとめたIgA単独欠損の解析
満生 紀子; 今井 耕輔; Xi YANG; 金兼 弘和; 小阪 嘉之; 高田 英俊; 水谷 修紀; 小原 収; 森尾 友宏
日本臨床免疫学会会誌, 36(5), 389a-389a, 2013, Refereed, Not invited
Lead - PDMS-CYTOP hybrid structure microwell array chip for total internal reflection fluorescence microscopy
A. Nakahara; Y. Shirasaki; J. Mizuno; T. Sekiguchi; O. Ohara; S. Shoji
8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013, 743-746, 2013, Refereed, Not invited
Lead - Novel mutation of IL2RG gene in a Korean boy with x-linked severe combined immunodeaficiency
Y. W. Lee; E. A. Yang; H. J. Kang; X. Yang; N. Mitsuiki; O. Ohara; T. Miyawaki; H. Kanegane; J. H. Lee
Journal of Investigational Allergology and Clinical Immunology, 23(1), 65-67, 2013, Refereed, Not invited
Lead - Down-regulation of CD5 expression on activated CD8+ T cells in familial hemophagocytic lymphohistiocytosis with perforin gene mutations
Taizo Wada; Yasuhisa Sakakibara; Ryosei Nishimura; Tomoko Toma; Yasuhisa Ueno; Seiki Horita; Taihei Tanaka; Masanori Nishi; Keisuke Kato; Takahiro Yasumi; Osamu Ohara; Akihiro Yachie
Human Immunology, 74(12), 1579-1585, 2013, Refereed, Not invited
Lead - Autosomal-dominant chronic mucocutaneous candidiasis with stat1-mutation can be complicated with chronic active hepatitis and hypothyroidism
Tomohiro Hori; Hidenori Ohnishi; Takahide Teramoto; Kohji Tsubouchi; Takafumi Naiki; Yoshinobu Hirose; Osamu Ohara; Mariko Seishima; Hideo Kaneko; Toshiyuki Fukao; Naomi Kondo
Journal of Clinical Immunology, 32(6), 1213-1220, Dec. 2012, Refereed, Not invited
Lead - Novel mutations of MVK gene in Japanese family members affected with hyperimmunoglobulinemia D and periodic fever syndrome
Takahisa Mizuno; Hidemasa Sakai; Ryuta Nishikomori; Koichi Oshima; Osamu Ohara; Ikue Hata; Yosuke Shigematsu; Takashi Ishige; Kazushi Tamura; Hirokazu Arakawa
RHEUMATOLOGY INTERNATIONAL, 32(12), 3761-3764, Dec. 2012, Refereed, Not invited
Lead - Autosomal-Dominant Chronic Mucocutaneous Candidiasis with STAT1-Mutation can be Complicated with Chronic Active Hepatitis and Hypothyroidism
Tomohiro Hori; Hidenori Ohnishi; Takahide Teramoto; Kohji Tsubouchi; Takafumi Naiki; Yoshinobu Hirose; Osamu Ohara; Mariko Seishima; Hideo Kaneko; Toshiyuki Fukao; Naomi Kondo
JOURNAL OF CLINICAL IMMUNOLOGY, 32(6), 1213-1220, Dec. 2012, Refereed, Not invited
Lead - Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory
Tomohiro Kaji; Akiko Ishige; Masaki Hikida; Junko Taka; Atsushi Hijikata; Masato Kubo; Takeshi Nagashima; Yoshimasa Takahashi; Tomohiro Kurosaki; Mariko Okada; Osamu Ohara; Klaus Rajewsky; Toshitada Takemori
JOURNAL OF EXPERIMENTAL MEDICINE, 209(11), 2079-2097, Oct. 2012, Refereed, Not invited
Lead - Chronic Mucocutaneous Candidiasis Caused by a Gain-of-Function Mutation in the STAT1 DNA-Binding Domain
Shunichiro Takezaki; Masafumi Yamada; Masahiko Kato; Myoung-ja Park; Kenichi Maruyama; Yasuhiro Yamazaki; Natsuko Chida; Osamu Ohara; Ichiro Kobayashi; Tadashi Ariga
JOURNAL OF IMMUNOLOGY, 189(3), 1521-1526, Aug. 2012, Refereed, Not invited
Lead - Histone H2A Mono-Ubiquitination Is a Crucial Step to Mediate PRC1-Dependent Repression of Developmental Genes to Maintain ES Cell Identity
Mitsuhiro Endoh; Takaho A. Endo; Tamie Endoh; Kyo-ichi Isono; Jafar Sharif; Osamu Ohara; Tetsuro Toyoda; Takashi Ito; Ragnhild Eskeland; Wendy A. Bickmore; Miguel Vidal; Bradley E. Bernstein; Haruhiko Koseki
PLOS GENETICS, 8(7), Jul. 2012, Refereed, Not invited
Lead - Conditional ablation of CD205(+) conventional dendritic cells impacts the regulation of T-cell immunity and homeostasis in vivo
Tomohiro Fukaya; Ryuichi Murakami; Hideaki Takagi; Kaori Sato; Yumiko Sato; Haruna Otsuka; Michiko Ohno; Atsushi Hijikata; Osamu Ohara; Masaki Hikida; Bernard Malissen; Katsuaki Sato
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(28), 11288-11293, Jul. 2012, Refereed, Not invited
Lead - Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity
Mitsuhiro Endoh; Takaho A. Endo; Tamie Endoh; Kyo-ichi Isono; Jafar Sharif; Osamu Ohara; Tetsuro Toyoda; Takashi Ito; Ragnhild Eskeland; Wendy A. Bickmore; Miguel Vidal; Bradley E. Bernstein; Haruhiko Koseki
PLoS Genetics, 8(7), e1002774, Jul. 2012, Refereed, Not invited
Lead - Delayed onset adenosine deaminase deficiency associated with acute disseminated encephalomyelitis.
Hideyuki Nakaoka; Hirokazu Kanegane; Hiromichi Taneichi; Kazushi Miya; Xi Yang; Keiko Nomura; Shunichiro Takezaki; Masafumi Yamada; Osamu Ohara; Chikako Kamae; Kohsuke Imai; Shigeaki Nonoyama; Taizo Wada; Akihiro Yachie; Michael S Hershfield; Tadashi Ariga; Toshio Miyawaki
International journal of hematology, 95(6), 692-6, Jun. 2012, Refereed, Not invited
Lead - PREDICTION OF TREATMENT RESPONSE OF TOCILIZUMAB FOR RHEUMATOID ARTHRITIS WITH COMPREHENSIVE GENE EXPRESSION ANALYSIS IN PERIPHERAL BLOOD MONONUCLEAR CELLS
Y. Sanayama; K. Ikeda; S. Kagami; S. Furuta; D. Kashiwakuma; I. Matsuura; M. Yamagata; I. Iwamoto; T. Umibe; R. Matsumura; T. Sugiyama; M. Sueishi; Y. Nawata; M. Hiraguri; K. Nonaka; O. Ohara; H. Nakajima
ANNALS OF THE RHEUMATIC DISEASES, 71, 384-384, Jun. 2012, Not invited
Lead - Delayed onset adenosine deaminase deficiency associated with acute disseminated encephalomyelitis
Hideyuki Nakaoka; Hirokazu Kanegane; Hiromichi Taneichi; Kazushi Miya; Xi Yang; Keiko Nomura; Shunichiro Takezaki; Masafumi Yamada; Osamu Ohara; Chikako Kamae; Kohsuke Imai; Shigeaki Nonoyama; Taizo Wada; Akihiro Yachie; Michael S. Hershfield; Tadashi Ariga; Toshio Miyawaki
INTERNATIONAL JOURNAL OF HEMATOLOGY, 95(6), 692-696, Jun. 2012, Refereed, Not invited
Lead - Identification of a New Pathway for Th1 Cell Development Induced by Cooperative Stimulation with IL-4 and TGF-beta
Soichi Tofukuji; Makoto Kuwahara; Junpei Suzuki; Osamu Ohara; Toshinori Nakayama; Masakatsu Yamashita
JOURNAL OF IMMUNOLOGY, 188(10), 4846-4857, May 2012, Refereed, Not invited
Lead - Roles of a macrophage molecule M-mod in type 2 diabetes
Hiroshi Kitamura; Masatoshi Ito; Shunsuke Kimura; Yoshinori Shimamoto; Tomomi Miyamoto; Hiroshi Watarai; Jun Okabe; Toshihiko Iwanaga; Osamu Ohara; Ichiro Miyoshi
FASEB JOURNAL, 26, Apr. 2012, Refereed, Not invited
Lead - Detection of Base Substitution-Type Somatic Mosaicism of the NLRP3 Gene with > 99.9% Statistical Confidence by Massively Parallel Sequencing
Kazushi Izawa; Atsushi Hijikata; Naoko Tanaka; Tomoki Kawai; Megumu K. Saito; Raphaela Goldbach-Mansky; Ivona Aksentijevich; Takahiro Yasumi; Tatsutoshi Nakahata; Toshio Heike; Ryuta Nishikomori; Osamu Ohara
DNA RESEARCH, 19(2), 143-152, Apr. 2012, Refereed, Not invited
Lead - Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation
Shinsuke Takagi; Yoriko Saito; Atsushi Hijikata; Satoshi Tanaka; Takashi Watanabe; Takanori Hasegawa; Shinobu Mochizuki; Jun Kunisawa; Hiroshi Kiyono; Haruhiko Koseki; Osamu Ohara; Takashi Saito; Shuichi Taniguchi; Leonard D. Shultz; Fumihiko Ishikawa
BLOOD, 119(12), 2768-2777, Mar. 2012, Refereed, Not invited
Lead - Clinical profile and genetic basis of Wiskott-Aldrich syndrome at Chandigarh, north India
Deepti Suri; Surjit Singh; Amit Rawat; Anju Gupta; Chikako Kamae; Kenichi Honma; Noriko Nakagawa; Kohsuke Imai; Shigeaki Nonoyama; Koichi Oshima; Noriko Mitsuiki; Osamu Ohara; Chrystele Bilhou-Nabera; Alexis Proust; Jasmina Ahluwalia; Sunil Dogra; Biman Saikia; Ranjana Walker Minz; Shobha Sehgal
ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, 30(1), 71-78, Mar. 2012, Refereed, Not invited
Lead - 3PS031 Live-cell secretion imaging assay of the inflammatory cytokine from human monocytes(The 50th Annual Meeting of the Biophysical Society of Japan)
Shirasaki Yoshitaka; Shimura Nanako; Suzuki Nobutake; Izawa Kazushi; Nakahara Asahi; Yamagishi Mai; Harada Yoshie; Shouji Shuichi; Nishikomori Ryuta; Ohara Osamu
Seibutsu Butsuri, 52, S151, 2012
Lead - Measurement of inflammatory cytokine secretion from human monocytes after inflammasome activation
Yoshitaka Shirasaki; Asahi Nakahara; Nanako Shimura; Kazushi Izawa; Nobutake Suzuki; Mai Yamagishi; Jun Mizuno; Tetsushi Sekiguchi; Ryuta Nishikomori; Shuichi Shoji; Osamu Ohara
Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, 1012-1014, 2012
Lead - Phosphopeptide shotgun analysis using mass spectrometry and Phos-tag agarose beads
木村弥生; 野村文子; 井野洋子; 小原收; 平野久
生物物理化学(Web), 56(Suppl_1), S25-S28 (J-STAGE)-S28, 2012, Refereed, Not invited
Lead - Two-dimensional Phos-tag affinity electrophoresis
木村弥生; 永田佳代子; 平野久; 小原收
生物物理化学(Web), 56(Suppl_1), S21-S24 (J-STAGE)-S24, 2012, Refereed, Not invited
Lead - Severe Primary Antibody Deficiency Due to a Novel Mutation of mu Heavy Chain
I. Mohammadzadeh; M. Yeganeh; A. Aghamohammadi; N. Parvaneh; N. Behniafard; H. Abolhassani; F. Tabassomi; M. Hemmat; H. Kanegane; T. Miyawaki; O. Ohara; N. Rezaei
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY, 22(1), 78-79, 2012, Refereed, Not invited
Lead - A Dual Reporter Splicing Assay Using HaloTag-containing Proteins.
Oshima K; Nagase T; Imai K; Nonoyama S; Obara M; Mizukami T; Nunoi H; Kanegane H; Kuribayashi F; Amemiya S; Ohara O
Current chemical genomics, 6, 27-37, 2012, Refereed, Not invited
Lead - XPS and NEXAFS studies of VUV/O-3-treated aromatic polyurea and its application to microchip electrophoresis
H. Shinohara; A. Nakahara; F. Kitagawa; Y. Takahashi; K. Otsuka; S. Shoji; O. Ohara; J. Mizuno
IET NANOBIOTECHNOLOGY, 5(4), 136-142, Dec. 2011, Refereed, Not invited
Lead - Plasmacytoid Dendritic Cells Are Crucial for the Initiation of Inflammation and T Cell Immunity In Vivo
Hideaki Takagi; Tomohiro Fukaya; Kawori Eizumi; Yumiko Sato; Kaori Sato; Azusa Shibazaki; Haruna Otsuka; Atsushi Hijikata; Takashi Watanabe; Osamu Ohara; Tsuneyasu Kaisho; Bernard Malissen; Katsuaki Sato
IMMUNITY, 35(6), 958-971, Dec. 2011, Refereed, Not invited
Lead - High Incidence of NLRP3 Somatic Mosaicism in Patients With Chronic Infantile Neurologic, Cutaneous, Articular Syndrome Results of an International Multicenter Collaborative Study
Naoko Tanaka; Kazushi Izawa; Megumu K. Saito; Mio Sakuma; Koichi Oshima; Osamu Ohara; Ryuta Nishikomori; Takeshi Morimoto; Naotomo Kambe; Raphaela Goldbach-Mansky; Ivona Aksentijevich; Genevieve de Saint Basile; Benedicte Neven; Marielle van Gijn; Joost Frenkel; Juan I. Arostegui; Jordi Yaguee; Rosa Merino; Mercedes Ibanez; Alessandra Pontillo; Hidetoshi Takada; Tomoyuki Imagawa; Tomoki Kawai; Takahiro Yasumi; Tatsutoshi Nakahata; Toshio Heike
ARTHRITIS AND RHEUMATISM, 63(11), 3625-3632, Nov. 2011, Refereed, Not invited
Lead - Hematopoietic stem cell transplantation with reduced intensity conditioning from a family haploidentical donor in an infant with familial hemophagocytic lymphohistocytosis
Hideaki Ohta; Emiko Miyashita; Ikuko Hirata; Risa Matsumura; Hisao Yoshida; Yoshiko Hashii; Takeshi Higashiura; Takahiro Yasumi; Yuuki Murata; Toshio Heike; Xi Yang; Hirokazu Kanegane; Osamu Ohara; Keiichi Ozono
INTERNATIONAL JOURNAL OF HEMATOLOGY, 94(3), 285-290, Sep. 2011, Refereed, Not invited
Lead - Integrated hydrophilic surface treatment system of vapor deposition polymerization and vacuum ultraviolet irradiation for chemical/biochemical microchips
H. Shinohara; T. Hori; S. Umeda; Y. Takahashi; S. Shoji; O. Ohara; J. Mizuno
MICROELECTRONIC ENGINEERING, 88(8), 2751-2754, Aug. 2011, Refereed, Not invited
Lead - Fabrication of high-aspect-ratio amorphous perfluorinated polymer structure for total internal reflection fluorescence microscopy
Asahi Nakahara; Yoshitaka Shirasaki; Kentaro Kawai; Osamu Ohara; Jun Mizuno; Shuichi Shoji
Microelectronic Engineering, 88(8), 1817-1820, Aug. 2011, Refereed, Not invited
Lead - Rapid diagnosis of FHL3 by flow cytometric detection of intraplatelet Munc13-4 protein
Yuuki Murata; Takahiro Yasumi; Ryutaro Shirakawa; Kazushi Izawa; Hidemasa Sakai; Junya Abe; Naoko Tanaka; Tomoki Kawai; Koichi Oshima; Megumu Saito; Ryuta Nishikomori; Osamu Ohara; Eiichi Ishii; Tatsutoshi Nakahata; Hisanori Horiuchi; Toshio Heike
BLOOD, 118(5), 1225-1230, Aug. 2011, Refereed, Not invited
Lead - Quantification of kappa-deleting recombination excision circles in Guthrie cards for the identification of early B-cell maturation defects
Noriko Nakagawa; Kohsuke Imai; Hirokazu Kanegane; Hiroki Sato; Masafumi Yamada; Kensuke Kondoh; Satoshi Okada; Masao Kobayashi; Kazunaga Agematsu; Hidetoshi Takada; Noriko Mitsuiki; Koichi Oshima; Osamu Ohara; Deepti Suri; Amit Rawat; Surjit Singh; Qiang Pan-Hammarstroem; Lennart Hammarstroem; Janine Reichenbach; Reinhard Seger; Tadashi Ariga; Toshiro Hara; Toshio Miyawaki; Shigeaki Nonoyama
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 128(1), 223-U352, Jul. 2011, Refereed, Not invited
Lead - Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue
Jun Kurokawa; Hiromichi Nagano; Osamu Ohara; Naoto Kubota; Takashi Kadowaki; Satoko Arai; Toru Miyazaki
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108(29), 12072-12077, Jul. 2011, Refereed, Not invited
Lead - ADA-SCID with 'WAZA-ARI' mutations that synergistically abolished ADA protein stability.
Yuka Okura; Masafumi Yamada; Ichiro Kobayashi; Ines Santisteban; Gabriella Arredondo-Santisteban; Zenichiro Kato; Akihiro Iguchi; Makoto Yoshida; Osamu Ohara; Noriko Nakagawa; Kohsuke Imai; Michael S Hershfield; Tadashi Ariga
British journal of haematology, 153(5), 675-6, Jun. 2011, Refereed, Not invited
Lead - Clinical and Host Genetic Characteristics of Mendelian Susceptibility to Mycobacterial Diseases in Japan
Takayuki Hoshina; Hidetoshi Takada; Yuka Sasaki-Mihara; Koichi Kusuhara; Koichi Ohshima; Satoshi Okada; Masao Kobayashi; Osamu Ohara; Toshiro Hara
JOURNAL OF CLINICAL IMMUNOLOGY, 31(3), 309-314, Jun. 2011, Refereed, Not invited
Lead - ADA-SCID with 'WAZA-ARI' mutations that synergistically abolished ADA protein stability
Yuka Okura; Masafumi Yamada; Ichiro Kobayashi; Ines Santisteban; Gabriella Arredondo-Santisteban; Zenichiro Kato; Akihiro Iguchi; Makoto Yoshida; Osamu Ohara; Noriko Nakagawa; Kohsuke Imai; Michael S. Hershfield; Tadashi Ariga
BRITISH JOURNAL OF HAEMATOLOGY, 153(5), 675-678, Jun. 2011, Refereed, Not invited
Lead - Wiskott-Aldrich syndrome mutation in two Turkish siblings with X-linked thrombocytopenia
Goksel Leblebisatan; Ali Bay; Noriko Mitsuiki; Osamu Ohara; Kenichi Honma; Kohsuke Imai; Shigeaki Nonoyama
TURKISH JOURNAL OF HEMATOLOGY, 28(2), 139-141, Jun. 2011, Refereed, Not invited
Lead - Analysis of mutations and recombination activity in RAG-deficient patients.
Asai E; Wada T; Sakakibara Y; Toga A; Toma T; Shimizu T; Nampoothiri S; Imai K; Nonoyama S; Morio T; Muramatsu H; Kamachi Y; Ohara O; Yachie A
Clin. Immunol., 138(2), 172-177, Feb. 2011, Refereed, Not invited
Lead - Analysis of mutations and recombination activity in RAG-deficient patients
Erika Asai; Taizo Wada; Yasuhisa Sakakibara; Akiko Toga; Tomoko Toma; Takashi Shimizu; Sheela Nampoothiri; Kohsuke Imai; Shigeaki Nonoyama; Tomohiro Morio; Hideki Muramatsu; Yoshiro Kamachi; Osamu Ohara; Akihiro Yachie
CLINICAL IMMUNOLOGY, 138(2), 172-177, Feb. 2011, Refereed, Not invited
Lead - Mammalian Polycomb-Like Pcl2/Mtf2 Is a Novel Regulatory Component of PRC2 That Can Differentially Modulate Polycomb Activity both at the Hox Gene Cluster and at Cdkn2a Genes
Xiangzhi Li; Kyo-ichi Isono; Daisuke Yamada; Takaho A. Endo; Mitsuhiro Endoh; Jun Shinga; Yoko Mizutani-Koseki; Arie P. Otte; Miguel Casanova; Hiroshi Kitamura; Takehiko Kamijo; Jafar Sharif; Osamu Ohara; Tetsuro Toyada; Bradley E. Bernstein; Neil Brockdorff; Haruhiko Koseki
MOLECULAR AND CELLULAR BIOLOGY, 31(2), 351-364, Jan. 2011, Refereed, Not invited
Lead - The RIKEN integrated database of mammals
Hiroshi Masuya; Yuko Makita; Norio Kobayashi; Koro Nishikata; Yuko Yoshida; Yoshiki Mochizuki; Koji Doi; Terue Takatsuki; Kazunori Waki; Nobuhiko Tanaka; Manabu Ishii; Akihiro Matsushima; Satoshi Takahashi; Atsushi Hijikata; Kouji Kozaki; Teiichi Furuichi; Hideya Kawaji; Shigeharu Wakana; Yukio Nakamura; Atsushi Yoshiki; Takehide Murata; Kaoru Fukami-Kobayashi; Sujatha Mohan; Osamu Ohara; Yoshihide Hayashizaki; Riichiro Mizoguchi; Yuichi Obata; Tetsuro Toyoda
NUCLEIC ACIDS RESEARCH, 39(Database issue), D861-D870, Jan. 2011, Refereed, Not invited
Lead - Single cell analysis of the proinflammatory responses of mast cell by a real time secretion assay
Y. Shirasaki; A. Nakahara; N. Shimura; N. Suzuki; M. Yamagishi; J. Mizuno; S. Shoji; O. Ohara
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, 2, 843-845, 2011
Lead - Diagnosis of NLRP3 somatic mosaicism in CINCA/NOMID patients using next-generation sequencing.
Izawa K; Nishikomori R; Tanikaze N; Saito M; Goldbach-Mansky R; Aksentijevich I; Yasumi T; Kawai T; Nakahata T; Heike T; Ohara O
2011
Lead - Single cell real time secretion assay using amorphous fluoropolymer microwell array
Y. Shirasaki; A. Nakahara; N. Shimura; M. Yamagishi; J. Mizuno; O. Ohara; S. Shoji
2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11, 755-758, 2011, Refereed, Not invited
Lead - An Integrated in Silico Approach to Deduce Interacting Domains of Primary Immunodeficiency Disease Causing Genes
Suresh Kumar Ramadoss; Akhilesh Pandey; Osamu Ohara; Sujatha Mohan
BIOSCIENCE, BIOCHEMISTRY AND BIOINFORMATICS, 5, 462-466, 2011, Refereed, Not invited
Lead - SP600125 Inhibits Cap-dependent Translation Independently of the c-Jun N-terminal Kinase Pathway
Masatoshi Ito; Hiroshi Kitamura; Chisato Kikuguchi; Koji Hase; Hiroshi Ohno; Osamu Ohara
CELL STRUCTURE AND FUNCTION, 36(1), 27-33, 2011, Refereed, Not invited
Lead - NetSlim: high-confidence curated signaling maps
Rajesh Raju; Vishalakshi Nanjappa; Lavanya Balakrishnan; Aneesha Radhakrishnan; Joji Kurian Thomas; Jyoti Sharma; Maozhen Tian; Shyam Mohan Palapetta; Tejaswini Subbannayya; Nirujogi Raja Sekhar; Babylakshmi Muthusamy; Renu Goel; Yashwanth Subbannayya; Deepthi Telikicherla; Mitali Bhattacharjee; Sneha M. Pinto; Nazia Syed; Manda Srinivas Srikanth; Gajanan J. Sathe; Sartaj Ahmad; Sandip N. Chavan; Ghantasala S. Sameer Kumar; Arivusudar Marimuthu; T. S. K. Prasad; H. C. Harsha; B. Abdul Rahiman; Osamu Ohara; Gary D. Bader; S. Sujatha Mohan; William P. Schiemann; Akhilesh Pandey
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION, 2011, bar032, 2011, Refereed, Not invited
Lead - Hemophagocytosis after bone marrow transplantation for JAK3-deficient severe combined immunodeficiency
Yoshiko Hashii; Hisao Yoshida; Sato Kuroda; Shigenori Kusuki; Emiko Sato; Sadao Tokimasa; Hideaki Ohta; Yasutaka Matsubara; Seiji Kinoshita; Noriko Nakagawa; Kohsuke Imai; Shigeaki Nonoyama; Koichi Oshima; Osamu Ohara; Keiichi Ozono
Pediatric Transplantation, 14(8), E105-E109, Dec. 2010, Refereed, Not invited
Lead - A network of conserved co-occurring motifs for the regulation of alternative splicing
Mikita Suyama; Eoghan D. Harrington; Svetlana Vinokourova; Magnus von Knebel Doeberitz; Osamu Ohara; Peer Bork
NUCLEIC ACIDS RESEARCH, 38(22), 7916-7926, Dec. 2010, Refereed, Not invited
Lead - A set of genes associated with the interferon-gamma response of lung cancer patients undergoing alpha-galactosylceramide-pulsed dendritic cell therapy
Kohsuke Okita; Shinichiro Motohashi; Ryo Shinnakasu; Kaoru Nagato; Kazuki Yamasaki; Yasunori Sato; Hiroshi Kitamura; Atsushi Hijikata; Masakatsu Yamashita; Kanako Shimizu; Shin-ichiro Fujii; Osamu Ohara; Masaru Taniguchi; Isao Sakaida; Toshinori Nakayama
CANCER SCIENCE, 101(11), 2333-2340, Nov. 2010, Refereed, Not invited
Lead - Characterization of multiple alternative forms of heterogeneous nuclear ribonucleoprotein K by phosphate-affinity electrophoresis
Yayoi Kimura; Kayoko Nagata; Nobutake Suzuki; Ryo Yokoyama; Yuko Yamanaka; Hiroshi Kitamura; Hisashi Hirano; Osamu Ohara
PROTEOMICS, 10(21), 3884-3895, Nov. 2010, Refereed, Not invited
Lead - A set of genes associated with the interferon-γ response of lung cancer patients undergoing α-galactosylceramide-pulsed dendritic cell therapy
Kohsuke Okita; Shinichiro Motohashi; Ryo Shinnakasu; Kaoru Nagato; Kazuki Yamasaki; Yasunori Sato; Hiroshi Kitamura; Atsushi Hijikata; Masakatsu Yamashita; Kanako Shimizu; Shin-Ichiro Fujii; Osamu Ohara; Masaru Taniguchi; Isao Sakaida; Toshinori Nakayama
International Journal of Psychoanalysis, 91(5), 2333-2340, Oct. 2010, Refereed, Not invited
Lead - Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells
Hiroshi Watarai; Shin-ichiro Fujii; Daisuke Yamada; Andrei Rybouchkin; Sakura Sakata; Yuko Nagata; Midori Iida-Kobayashi; Etsuko Sekine-Kondo; Kanako Shimizu; Yohei Shozaki; Jafar Sharif; Masashi Matsuda; Shinobu Mochiduki; Takanori Hasegawa; Genta Kitahara; Takaho A. Endo; Tetsuro Toyoda; Osamu Ohara; Ken-ichi Harigaya; Haruhiko Koseki; Masaru Taniguchi
JOURNAL OF CLINICAL INVESTIGATION, 120(7), 2610-2618, Jul. 2010, Refereed, Not invited
Lead - Hyper IgM syndrome and complement Clq deficiency in an individual with systemic lupus erythematosus-like disease
I. Tsuge; Y. Kondo; Y. Nakajima; N. Nakagawa; K. Imai; S. Nonoyama; K. Oshima; O. Ohara; M. Hatanaka; E. Kitano; H. Kitamura; A. Urisu
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 28(4), 558-560, Jul. 2010, Refereed, Not invited
Lead - Erratum: The NMR solution structures of the five constituent old-shock domains (CSD) of the human UNR (upstream of N-ras) protein (Journal of Structural and Functional Genomics (2010) DOI: 10.1007/s10969-010-9081-z)
Alexander K. Goroncy; Seizo Koshiba; Naoya Tochio; Tadashi Tomizawa; Makoto Inoue; Satoru Watanabe; Takushi Harada; Akiko Tanaka; Osamu Ohara; Takanori Kigawa; Shigeyuki Yokoyama
Journal of Structural and Functional Genomics, 11(2), 189, Jun. 2010, Refereed, Not invited
Lead - The NMR solution structures of the five constituent cold-shock domains (CSD) of the human UNR (upstream of N-ras) protein
Alexander K. Goroncy; Seizo Koshiba; Naoya Tochio; Tadashi Tomizawa; Makato Inoue; Satoru Watanabe; Takushi Harada; Akiko Tanaka; Osamu Ohara; Takanori Kigawa; Shigeyuki Yokoyama
Journal of Structural and Functional Genomics, 11(2), 181-188, Jun. 2010, Refereed, Not invited
Lead - Mutation@A Glance: An Integrative Web Application for Analysing Mutations from Human Genetic Diseases
Atsushi Hijikata; Ajesh Raju; Shivakumar Keerthikumar; Subhashri Ramabadran; Lavanya Balakrishnan; Suresh Kumar Ramadoss; Akhilesh Pandey; Sujatha Mohan; Osamu Ohara
DNA RESEARCH, 17(3), 197-208, Jun. 2010, Refereed, Not invited
Lead - Unique activation status of peripheral blood mononuclear cells at acute phase of Kawasaki disease
K. Ikeda; K. Yamaguchi; T. Tanaka; Y. Mizuno; A. Hijikata; O. Ohara; H. Takada; K. Kusuhara; T. Hara
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 160(2), 246-255, May 2010, Refereed, Not invited
Lead - A case of familial Mediterranean fever associated with compound heterozygosity for the pyrin variant L110P-E148Q/M680I in Japan
Koichi Oshima; Kazuko Yamazaki; Yoichi Nakajima; Akari Kobayashi; Tomochika Kato; Osamu Ohara; Kazunaga Agematsu
MODERN RHEUMATOLOGY, 20(2), 193-195, Apr. 2010, Refereed, Not invited
Lead - Identification of Therapeutic Targets for Quiescent, Chemotherapy-Resistant Human Leukemia Stem Cells
Yoriko Saito; Hiroshi Kitamura; Atsushi Hijikata; Mariko Tomizawa-Murasawa; Satoshi Tanaka; Shinsuke Takagi; Naoyuki Uchida; Nahoko Suzuki; Akiko Sone; Yuho Najima; Hidetoshi Ozawa; Atsushi Wake; Shuichi Taniguchi; Leonard D. Shultz; Osamu Ohara; Fumihiko Ishikawa
SCIENCE TRANSLATIONAL MEDICINE, 2(17), 17ra9, Feb. 2010, Refereed, Not invited
Lead - NetPath: A public resource of curated signal transduction pathways
Kumaran Kandasamy; S. Sujatha Mohan; Rajesh Raju; Shivakumar Keerthikumar; Ghantasala S. Sameer Kumar; Abhilash K. Venugopal; Deepthi Telikicherla; Daniel J. Navarro; Suresh Mathivanan; Christian Pecquet; Sashi Kanth Gollapudi; Sudhir Gopal Tattikota; Shyam Mohan; Hariprasad Padhukasahasram; Yashwanth Subbannayya; Renu Goel; Harrys K.C. Jacob; Jun Zhong; Raja Sekhar; Vishalakshi Nanjappa; Lavanya Balakrishnan; Roopashree Subbaiah; Y. L. Ramachandra; B. Abdul Rahiman; T. S. Keshava Prasad; Jian-Xin Lin; Jon C.D. Houtman; Stephen Desiderio; Jean-Christophe Renauld; Stefan Constantinescu; Osamu Ohara; Toshio Hirano; Masato Kubo; Sujay Singh; Purvesh Khatri; Sorin Draghici; Gary D. Bader; Chris Sander; Warren J. Leonard; Akhilesh Pandey
Genome Biology, 11(1), R3, Jan. 2010, Refereed, Not invited
Lead - ヘテロ核リボヌクレオタンパク質のモディフィコミクス
木村 弥生; 永田 佳代子; 北村 浩; 平野 久; 小原 收
日本プロテオーム学会大会要旨集, 2010, 54-54, 2010
Lead - 1P324 Kinetic analysis of LPS-activation in macrophage-like cells based on a quantification system for gene expression level in a single cell(Measurements,The 48th Annual Meeting of the Biophysical Society of Japan)
Yamagishi Mai; Shirasaki Yoshitaka; Shimura Nanako; Ohara Osamu
Seibutsu Butsuri, 50(2), S77, 2010
Lead - 3P300 Structural basis for impairment of genes in human inherited disorders(Bioinformatics: Functional genomics,The 48th Annual Meeting of the Biophysical Society of Japan)
Hijikata Atsushi; Ohara Osamu
Seibutsu Butsuri, 50(2), S198, 2010
Lead - 2P332 Quantitative measurement of protein secretion from a single cell in real time(The 48th Annual Meeting of the Biophysical Society of Japan)
Shirasaki Yoshitaka; Yamagishi Mai; Nakamura Asahi; Sasuga Yasuhiro; Suzuki Nobutake; Shimura Nanako; Kawai Kentaro; Mizuno Jun; Shoji Shuichi; Harada Yoshie; Ohara Osamu
Seibutsu Butsuri, 50(2), S141, 2010
Lead - NetPath: a public resource of curated signal transduction pathways
Kumaran Kandasamy; S. Sujatha Mohan; Rajesh Raju; Shivakumar Keerthikumar; Ghantasala S. Sameer Kumar; Abhilash K. Venugopal; Deepthi Telikicherla; J. Daniel Navarro; Suresh Mathivanan; Christian Pecquet; Sashi Kanth Gollapudi; Sudhir Gopal Tattikota; Shyam Mohan; Hariprasad Padhukasahasram; Yashwanth Subbannayya; Renu Goel; Harrys K. C. Jacob; Jun Zhong; Raja Sekhar; Vishalakshi Nanjappa; Lavanya Balakrishnan; Roopashree Subbaiah; Y. L. Ramachandra; B. Abdul Rahiman; T. S. Keshava Prasad; Jian-Xin Lin; Jon C. D. Houtman; Stephen Desiderio; Jean-Christophe Renauld; Stefan N. Constantinescu; Osamu Ohara; Toshio Hirano; Masato Kubo; Sujay Singh; Purvesh Khatri; Sorin Draghici; Gary D. Bader; Chris Sander; Warren J. Leonard; Akhilesh Pandey
GENOME BIOLOGY, 11(1), 2010, Refereed, Not invited
Lead - A microfluidic mammalian cell sorter with thermal gelation polymer solution
Shirasaki Y; Goto M; Sugino H; Arakawa T; Yoon D; Mizuno J; Shoji S; Funatsu T; Ohara O
14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010, 3, 1571-1573, 2010, Refereed, Not invited
Lead - Defining the immunological phenotype of Fc receptor-like B (FCRLB) deficient mice: Confounding role of the inhibitory Fc gamma RIIb
Keiji Masuda; Hiromi Mori; Osamu Ohara; Manabu Nakayama; Ji-Yang Wang; Peter D. Burrows
CELLULAR IMMUNOLOGY, 266(1), 24-31, 2010, Refereed, Not invited
Lead - Ataxia-Telangiectasia in a Patient Presenting With Hyper-immunoglobulin M Syndrome
A. Aghamohammadi; K. Imai; K. Moazzami; H. Abolhassani; M. Tabatabaeiyan; N. Parvaneh; R. Nasiri Kalmarzi; N. Nakagawa; K. Oshima; O. Ohara; S. Nonoyama; N. Rezaei
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY, 20(5), 442-445, 2010, Refereed, Not invited
Lead - The completion of the Mammalian Gene Collection (MGC)
Gary Temple; Daniela S. Gerhard; Rebekah Rasooly; Elise A. Feingold; Peter J. Good; Cristen Robinson; Allison Mandich; Jeffrey G. Derge; Jeanne Lewis; Debonny Shoaf; Francis S. Collins; Wonhee Jang; Lukas Wagner; Carolyn M. Shenmen; Leonie Misquitta; Carl F. Schaefer; Kenneth H. Buetow; Tom I. Bonner; Linda Yankie; Ming Ward; Lon Phan; Alex Astashyn; Garth Brown; Catherine Farrell; Jennifer Hart; Melissa Landrum; Bonnie L. Maidak; Michael Murphy; Terence Murphy; Bhanu Rajput; Lillian Riddick; David Webb; Janet Weber; Wendy Wu; Kim D. Pruitt; Donna Maglott; Adam Siepel; Brona Brejova; Mark Diekhans; Rachel Harte; Robert Baertsch; Jim Kent; David Haussler; Michael Brent; Laura Langton; Charles L. G. Comstock; Michael Stevens; Chaochun Wei; Marijke J. van Baren; Kourosh Salehi-Ashtiani; Ryan R. Murray; Lila Ghamsari; Elizabeth Mello; Chenwei Lin; Christa Pennacchio; Kirsten Schreiber; Nicole Shapiro; Amber Marsh; Elizabeth Pardes; Troy Moore; Anita Lebeau; Mike Muratet; Blake Simmons; David Kloske; Stephanie Sieja; James Hudson; Praveen Sethupathy; Michael Brownstein; Narayan Bhat; Joseph Lazar; Howard Jacob; Chris E. Gruber; Mark R. Smith; John McPherson; Angela M. Garcia; Preethi H. Gunaratne; Jiaqian Wu; Donna Muzny; Richard A. Gibbs; Alice C. Young; Gerard G. Bouffard; Robert W. Blakesley; Jim Mullikin; Eric D. Green; Mark C. Dickson; Alex C. Rodriguez; Jane Grimwood; Jeremy Schmutz; Richard M. Myers; Martin Hirst; Thomas Zeng; Kane Tse; Michelle Moksa; Merinda Deng; Kevin Ma; Diana Mah; Johnson Pang; Greg Taylor; Eric Chuah; Athena Deng; Keith Fichter; Anne Go; Stephanie Lee; Jing Wang; Malachi Griffith; Ryan Morin; Richard A. Moore; Michael Mayo; Sarah Munro; Susan Wagner; Steven J. M. Jones; Robert A. Holt; Marco A. Marra; Sun Lu; Shuwei Yang; James Hartigan; Marcus Graf; Ralf Wagner; Stanley Letovksy; Jacqueline C. Pulido; Keith Robison; Dominic Esposito; James Hartley; Vanessa E. Wall; Ralph F. Hopkins; Osamu Ohara; Stefan Wiemann
GENOME RESEARCH, 19(12), 2324-2333, Dec. 2009, Refereed, Not invited
Lead - Prediction of Candidate Primary Immunodeficiency Disease Genes Using a Support Vector Machine Learning Approach
Shivakumar Keerthikumar; Sahely Bhadra; Kumaran Kandasamy; Rajesh Raju; Y. L. Ramachandra; Chiranjib Bhattacharyya; Kohsuke Imai; Osamu Ohara; Sujatha Mohan; Akhilesh Pandey
DNA RESEARCH, 16(6), 345-351, Dec. 2009, Refereed, Not invited
Lead - Cutting Edge: Requirement of MARCH-I-Mediated MHC II Ubiquitination for the Maintenance of Conventional Dendritic Cells
Mari Ohmura-Hoshino; Yohei Matsuki; Mari Mito-Yoshida; Eiji Goto; Masami Aoki-Kawasumi; Manabu Nakayama; Osamu Ohara; Satoshi Ishido
JOURNAL OF IMMUNOLOGY, 183(11), 6893-6897, Dec. 2009, Refereed, Not invited
Lead - Deficiency of the oxidative damage-specific DNA glycosylase NEIL1 leads to reduced germinal center B cell expansion
Hiromi Mori; Rika Ouchidaa; Atsushi Hijikata; Hiroshi Kitamura; Osamu Oharab; Yingqian Li; Xiang Gao; Akira Yasui; R. Stephen Lloyd; Ji-Yang Wang
DNA REPAIR, 8(11), 1328-1332, Nov. 2009, Refereed, Not invited
Lead - Structural and Functional Characterization of the NHR1 Domain of the Drosophila Neuralized E3 Ligase in the Notch Signaling Pathway
Fahu He; Kohei Salto; Naohiro Kobayashi; Takushi Harada; Satoru Watanabe; Takanori Kigawa; Peter Guentert; Osamu Ohara; Akiko Tanaka; Satoru Unzai; Yutaka Muto; Shigeyuki Yokoyama
JOURNAL OF MOLECULAR BIOLOGY, 393(2), 478-495, Oct. 2009, Refereed, Not invited
Lead - Two brothers with ataxia-telangiectasia-like disorder with lung adenocarcinoma.
Uchisaka N; Takahashi N; Sato M; Kikuchi A; Mochizuki S; Imai K; Nonoyama S; Ohara O; Watanabe F; Mizutani S; Hanada R; Morio T
J. Pediatr., 155(3), 435-438, Sep. 2009, Refereed, Not invited
Lead - Two Brothers with Ataxia-Telangiectasia-like Disorder with Lung Adenocarcinoma
Naoki Uchisaka; Naomi Takahashi; Masaki Sato; Akira Kikuchi; Shinji Mochizuki; Kohsuke Imai; Shigeaki Nonoyama; Osamu Ohara; Fumiaki Watanabe; Shuki Mizutani; Ryoji Hanada; Tomohiro Morio
JOURNAL OF PEDIATRICS, 155(3), 435-438, Sep. 2009, Refereed, Not invited
Lead - Mina, an Il4 repressor, controls T helper type 2 bias
Mariko Okamoto; Melanie Van Stry; Linda Chung; Madoka Koyanagi; Xizhang Sun; Yoshie Suzuki; Osamu Ohara; Hiroshi Kitamura; Atsushi Hijikata; Masato Kubo; Mark Bix
NATURE IMMUNOLOGY, 10(8), 872-U98, Aug. 2009, Refereed, Not invited
Lead - From transcriptome analysis to immunogenomics: Current status and future direction
Osamu Ohara
FEBS LETTERS, 583(11), 1662-1667, Jun. 2009, Refereed, Not invited
Lead - Naturally occurring regulatory dendritic cells regulate murine cutaneous chronic graft-versus-host disease
Kaori Sato; Kawori Eizumi; Tomohiro Fukaya; Shigeharu Fujita; Yumiko Sato; Hideaki Takagi; Mai Yamamoto; Naohide Yamashita; Atsushi Hijikata; Hiroshi Kitamura; Osamu Ohara; Sho Yamasaki; Takashi Saito; Katsuaki Sato
BLOOD, 113(19), 4780-4789, May 2009, Refereed, Not invited
Lead - Novel Subset of CD8 alpha(+) Dendritic Cells Localized in the Marginal Zone Is Responsible for Tolerance to Cell-Associated Antigens
Chun-Hong Qiu; Yasunobu Miyake; Hitomi Kaise; Hiroshi Kitamura; Osamu Ohara; Masato Tanaka
JOURNAL OF IMMUNOLOGY, 182(7), 4127-4136, Apr. 2009, Refereed, Not invited
Lead - Dispensable role of protein 4.1B/DAL-1 in rodent adrenal medulla regarding generation of pheochromocytoma and plasmalemmal localization of TSLC1
Nobuhiko Ohno; Nobuo Terada; Masayuki Komada; Sei Saitoh; Frank Costantini; Virgilio Pace; Paul-Georg Germann; Klaus Weber; Hisashi Yamakawa; Osamu Ohara; Shinichi Ohno
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1793(3), 506-515, Mar. 2009, Refereed, Not invited
Lead - Dispensable role of protein 4.1B/DAL-1 in rodent adrenal medulla regarding generation of pheochromocytoma and plasmalemmal localization of TSLC1.
Ohno N; Terada N; Komada M; Saitoh S; Costantini F; Pace V; Germann PG; Weber K; Yamakawa H; Ohara O; Ohno S
Biochimica et biophysica acta, 1793(3), 506-515, Mar. 2009, Refereed, Not invited
Lead - PCDH24-induced contact inhibition involves downregulation of beta-catenin signaling
Rui Ose; Toshihide Yanagawa; Shun Ikeda; Osamu Ohara; Hisashi Koga
MOLECULAR ONCOLOGY, 3(1), 54-66, Feb. 2009, Refereed, Not invited
Lead - RAPID: Resource of Asian Primary Immunodeficiency Diseases
Shivakumar Keerthikumar; Rajesh Raju; Kumaran Kandasamy; Atsushi Hijikata; Subhashri Ramabadran; Lavanya Balakrishnan; Mukhtar Ahmed; Sandhya Rani; Lakshmi Dhevi N. Selvan; Devi S. Somanathan; Somak Ray; Mitali Bhattacharjee; Sashikanth Gollapudi; Y. L. Ramachandra; Sahely Bhadra; Chiranjib Bhattacharyya; Kohsuke Imai; Shigeaki Nonoyama; Hirokazu Kanegane; Toshio Miyawaki; Akhilesh Pandey; Osamu Ohara; Sujatha Mohan
NUCLEIC ACIDS RESEARCH, 37(Database issue), D863-D867, Jan. 2009, Refereed, Not invited
Lead - A Novel Protein Array Using Microbeads Aligned In A Microfluidic Chip
Osamu Ohara
Biophysical Journal, 2009
Lead - ORFeome cloning.
Ohara O
Methods in Molecular Biology, 577, 3-9, 2009, Refereed, Not invited
Lead - Pulse-chase experiment for the analysis of protein stability in cultured mammalian cells by covalent fluorescent labeling of fusion proteins.
Yamaguchi K; Inoue S; Ohara O; Nagase T
Methods in molecular biology (Clifton, N.J.), 577, 121-131, 2009, Refereed, Not invited
Lead - Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice
Kitajima, M.; Iwamura, C.; Miki-Hosokawa, T.; Shinoda, K.; Endo, Y.; Watanabe, Y.; Shinnakasu, R.; Hosokawa, H.; Hashimoto, K.; Motohashi, S.; Koseki, H.; Ohara, O.; Yamashita, M.; Nakayama, T.
Journal of Immunology, 183(8), 5388-5396, 2009, Refereed, Not invited
Lead - Single-Cell Chemical Lysis Method for Analyses of Intracellular Molecules Using an Array of Picoliter-Scale Microwells
Yasuhiro Sasuga; Tomoyuki Iwasawa; Kayoko Terada; Yoshihiro Oe; Hiroyuki Sorimachi; Osamu Ohara; Yoshie Harada
ANALYTICAL CHEMISTRY, 80(23), 9141-9149, Dec. 2008, Refereed, Not invited
Lead - The Zinc Transporter SLC39A13/ZIP13 Is Required for Connective Tissue Development; Its Involvement in BMP/TGF-beta Signaling Pathways
Toshiyuki Fukada; Natacha Civic; Tatsuya Furuichi; Shinji Shimoda; Kenji Mishima; Hiroyuki Higashiyama; Yayoi Idaira; Yoshinobu Asada; Hiroshi Kitamura; Satoru Yamasaki; Shintaro Hojyo; Manabu Nakayama; Osamu Ohara; Haruhiko Koseki; Heloisa G. dos Santos; Luisa Bonafe; Russia Ha-Vinh; Andreas Zankl; Sheila Unger; Marius E. Kraenzlin; Jacques S. Beckmann; Ichiro Saito; Carlo Rivolta; Shiro Ikegawa; Andrea Superti-Furga; Toshio Hirano
PLOS ONE, 3(11), e3642, Nov. 2008, Refereed, Not invited
Lead - The novel protein complex with SMARCAD1/KIAA1122 binds to the vicinity of TSS
Noriko Okazaki; Shun Ikeda; Reiko Ohara; Kiyo Shimada; Toshihide Yanagawa; Takahiro Nagase; Osamu Ohara; Hisashi Koga
JOURNAL OF MOLECULAR BIOLOGY, 382(2), 257-265, Oct. 2008, Refereed, Not invited
Lead - Discriminating gene expression profiles of memory B cell subpopulations
Goetz R. A. Ehrhardt; Atsushi Hijikata; Hiroshi Kitamura; Osamu Ohara; Ji-Yang Wang; Max D. Cooper
JOURNAL OF EXPERIMENTAL MEDICINE, 205(8), 1807-1817, Aug. 2008, Refereed, Not invited
Lead - Exploration of human ORFeome: High-throughput preparation of ORF clones and efficient characterization of their protein products
Takahiro Nagase; Hisashi Yamakawa; Shinichi Tadokoro; Daisuke Nakajima; Shinichi Inoue; Kei Yamaguchi; Yasuhide Itokawa; Reiko F. Kikuno; Hisashi Koga; Osamu Ohara
DNA RESEARCH, 15(3), 137-149, Jun. 2008, Refereed, Not invited
Lead - BREK/LMTK2 is a myosin VI-binding protein involved in endosomal membrane trafficking
Takeshi Inoue; Takahide Kon; Reiko Ohkura; Hisashi Yamakawa; Osamu Ohara; Jun Yokota; Kazuo Sutoh
GENES TO CELLS, 13(5), 483-495, May 2008, Refereed, Not invited
Lead - Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway
Kei Yamaguchi; Osamu Ohara; Alkilkazu Ando; Takahiro Nagase
BIOLOGICAL CHEMISTRY, 389(4), 405-413, Apr. 2008, Refereed, Not invited
Lead - Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity
Mitsuhiro Endoh; Takaho A. Endo; Tamie Endoh; Yu-ichi Fujimura; Osamu Ohara; Tetsuro Toyoda; Arie P. Otte; Masaki Okano; Neil Brockdorff; Miguel Vidal; Haruhiko Koseki
DEVELOPMENT, 135(8), 1513-1524, Apr. 2008, Refereed, Not invited
Lead - Genome-wide identification and characterization of transcripts translationally regulated by bacterial lipopolysaccharide in macrophage-like J774.1 cells
Hiroshi Kitamura; Masatoshi Ito; Tomoko Yuasa; Chisato Kikuguchi; Atsushi Hijikata; Michiyo Takayama; Yayoi Kimura; Ryo Yokoyama; Tomohiro Kaji; Osamu Ohara
PHYSIOLOGICAL GENOMICS, 33(1), 121-132, Mar. 2008, Refereed, Not invited
Lead - Germline mutations of MEK in cardio-facio-cutaneous syndrome are sensitive to MEK and RAF inhibition: implications for therapeutic options
Thanaset Senawong; Janyaporn Phuchareon; Osamu Ohara; Frank McCormick; Katherine A. Rauen; Osamu Tetsu
HUMAN MOLECULAR GENETICS, 17(3), 419-430, Feb. 2008, Refereed, Not invited
Lead - Human Proteinpedia enables sharing of human protein data
Suresh Mathivanan; Mukhtar Ahmed; Natalie G. Ahn; Alexandre Hainard; Ramars Amanchy; Philip C. Andrews; Joel S. Bader; Brian M. Balgley; Marcus Bantscheff; Keiryn L. Bennett; Erik Bjoerling; Blagoy Blagoev; Ron Bose; Samir K. Brahmachari; Alma S. Burlingame; Xose R. Bustelo; Gerard Cagney; Greg T. Cantin; Helene L. Cardasis; Julio E. Celis; Raghothama Chaerkady; Feixia Chu; Philip A. Cole; Catherine E. Costello; Robert J. Cotter; David Crockett; James P. DeLany; Angelo M. De Marzo; Leroi V. DeSouza; Eric W. Deutsch; Eric Dransfield; Gerard Drewes; Arnaud Droit; Michael J. Dunn; Kojo Elenitoba-Johnson; Rob M. Ewing; Jennifer Van Eyk; Vitor Faca; Jayson Falkner; Xiangming Fang; Catherine Fenselau; Daniel Figeys; Pierre Gagne; Cecilia Gelfi; Kris Gevaert; Jeffrey M. Gimble; Florian Gnad; Renu Goel; Pavel Gromov; Samir M. Hanash; William S. Hancock; H. C. Harsha; Gerald Hart; Faith Hays; Fuchu He; Prashantha Hebbar; Kenny Helsens; Heiko Hermeking; Winston Hide; Karin Hjerno; Denis F. Hochstrasser; Oliver Hofmann; David M. Horn; Ralph H. Hruban; Nieves Ibarrola; Peter James; Ole N. Jensen; Pia Honnerup Jensen; Peter Jung; Kumaran Kandasamy; Indu Kheterpal; Reiko F. Kikuno; Ulrike Korf; Roman Koerner; Bernhard Kuster; Min-Seok Kwon; Hyoung-Joo Lee; Young-Jin Lee; Michael Lefevre; Minna Lehvaslaiho; Pierre Lescuyer; Fredrik Levander; Megan S. Lim; Christian Loebke; Joseph A. Loo; Matthias Mann; Lennart Martens; Juan Martinez-Heredia; Mark McComb; James McRedmond; Alexander Mehrle; Rajasree Menon; Christine A. Miller; Harald Mischak; S. Sujatha Mohan; Riaz Mohmood; Henrik Molina; Michael F. Moran; James D. Morgan; Robert Moritz; Martine Morzel; David C. Muddiman; Anuradha Nalli; J. Daniel Navarro; Thomas A. Neubert; Osamu Ohara; Rafael Oliva; Gilbert S. Omenn; Masaaki Oyama; Young-Ki Paik; Kyla Pennington; Rainer Pepperkok; Balamurugan Periaswamy; Emanuel F. Petricoin; Guy G. Poirier; T. S. Keshava Prasad; Samuel O. Purvine; B. Abdul Rahiman; Prasanna Ramachandran; Y. L. Ramachandra; Robert H. Rice; Jens Rick; Ragna H. Ronnholm; Johanna Salonen; Jean-Charles Sanchez; Thierry Sayd; Beerelli Seshi; Kripa Shankari; Shi Jun Sheng; Vivekananda Shetty; K. Shivakumar; Richard J. Simpson; Ravi Sirdeshmukh; K. W. Michael Siu; Jeffrey C. Smith; Richard D. Smith; David J. States; Sumio Sugano; Matthew Sullivan; Giulio Superti-Furga; Maarit Takatalo; Visith Thongboonkerd; Jonathan C. Trinidad; Mathias Uhlen; Joel Vandekerckhove; Julian Vasilescu; Timothy D. Veenstra; Jose-Manuel Vidal-Taboada; Mauno Vihinen; Robin Wait; Xiaoyue Wang; Stefan Wiemann; Billy Wu; Tao Xu; John R. Yates; Jun Zhong; Ming Zhou; Yunping Zhu; Petra Zurbig; Akhilesh Pandey
NATURE BIOTECHNOLOGY, 26(2), 164-167, Feb. 2008, Refereed, Not invited
Lead - Heterotrimeric G protein beta gamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42
Hiroshi Ueda; Rika Nagae; Mika Kozawa; Rika Morishita; Shinji Kimura; Takahiro Nagase; Osamu Ohara; Satoshi Yoshida; Tomiko Asano
JOURNAL OF BIOLOGICAL CHEMISTRY, 283(4), 1946-1953, Jan. 2008, Refereed, Not invited
Lead - Heterotrimeric G protein beta gamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42
Hiroshi Ueda; Rika Nagae; Mika Kozawa; Rika Morishita; Shinji Kimura; Takahiro Nagase; Osamu Ohara; Satoshi Yoshida; Tomiko Asano
JOURNAL OF BIOLOGICAL CHEMISTRY, 283(4), 1946-1953, Jan. 2008, Refereed, Not invited
Lead - The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts
Chisato Yamasaki; Katsuhiko Murakami; Yasuyuki Fujii; Yoshiharu Sato; Erimi Harada; Jun-Ichi Takeda; Takayuki Taniya; Ryuichi Sakate; Shingo Kikugawa; Makoto Shimada; Motohiko Tanino; Kanako O. Koyanagi; Roberto A. Barrero; Craig Gough; Hong-Woo Chun; Takuya Habara; Hideki Hanaoka; Yosuke Hayakawa; Phillip B. Hilton; Yayoi Kaneko; Masako Kanno; Yoshihiro Kawahara; Toshiyuki Kawamura; Akihiro Matsuya; Naoki Nagata; Kensaku Nishikata; Akiko Ogura Noda; Shin Nurimoto; Naomi Saichi; Hiroaki Sakai; Ryoko Sanbonmatsu; Rie Shiba; Mami Suzuki; Kazuhiko Takabayashi; Aiko Takahashi; Takuro Tamura; Masayuki Tanaka; Susumu Tanaka; Fusano Todokoro; Kaori Yamaguchi; Naoyuki Yamamoto; Toshihisa Okido; Jun Mashima; Aki Hashizume; Lihua Jin; Kyung-Bum Lee; Yi-Chueh Lin; Asami Nozaki; Katsunaga Sakai; Masahito Tada; Satoru Miyazaki; Takashi Makino; Hajime Ohyanagi; Naoki Osato; Nobuhiko Tanaka; Yoshiyuki Suzuki; Kazuho Ikeo; Naruya Saitou; Hideaki Sugawara; Claire O'Donovan; Tamara Kulikova; Eleanor Whitfield; Brian Halligan; Mary Shimoyama; Simon Twigger; Kei Yura; Kouichi Kimura; Tomohiro Yasuda; Tetsuo Nishikawa; Yutaka Akiyama; Chie Motono; Yuri Mukai; Hideki Nagasaki; Makiko Suwa; Paul Horton; Reiko Kikuno; Osamu Ohara; Doron Lancet; Eric Eveno; Esther Graudens; Sandrine Imbeaud; Marie Anne Debily; Yoshihide Hayashizaki; Clara Amid; Michael Han; Andreas Osanger; Toshinori Endo; Michael A. Thomas; Mika Hirakawa; Wojciech Makalowski; Mitsuteru Nakao; Nam-Soon Kim; Hyang-Sook Yoo; Sandro J. De Souza; Maria de Fatima Bonaldo; Yoshihito Niimura; Vladimir Kuryshev; Ingo Schupp; Stefan Wiemann; Matthew Bellgard; Masafumi Shionyu; Libin Jia; Danielle Thierry-Mieg; Jean Thierry-Mieg; Lukas Wagner; Qinghua Zhang; Mitiko Go; Shinsei Minoshima; Masafumi Ohtsubo; Kousuke Hanada; Peter Tonellato; Takao Isogai; Ji Zhang; Boris Lenhard; Sangsoo Kim; Zhu Chen; Ursula Hinz; Anne Estreicher; Kenta Nakai; Izabela Makalowska; Winston Hide; Nicola Tiffin; Laurens Wilming; Ranajit Chakraborty; Marcelo Bento Soares; Maria Luisa Chiusano; Yutaka Suzuki; Charles Auffray; Yumi Yamaguchi-Kabata; Takeshi Itoh; Teruyoshi Hishiki; Satoshi Fukuchi; Ken Nishikawa; Sumio Sugano; Nobuo Nomura; Yoshio Tateno; Tadashi Imanishi; Takashi Gojobori
NUCLEIC ACIDS RESEARCH, 36(Database issue), D793-D799, Jan. 2008, Refereed, Not invited
Lead - 3P-054 A novel protein array using microbeads aligned in a microfluidic chip(The 46th Annual Meeting of the Biophysical Society of Japan)
Ooe Yoshihiro; Sasuga Yasuhiro; Ohara Osamu; Harada Yoshie
Seibutsu Butsuri, 48, S135-S136, 2008
Lead - 1P-325 Mammalian cells sorting with thermal gelation polymer solution on a PDMS chip fabricated using one step 3D casting technique(The 46th Annual Meeting of the Biophysical Society of Japan)
Shirasaki Yoshitaka; Arakawa Takahiro; Sugino Hirokazu; Mizuno Jun; Shoji Shuichi; Funatsu Takashi; Ohara Osamu
Seibutsu Butsuri, 48, S72, 2008
Lead - Severe developmental delay and epilepsy in a Japanese patient with severe congenital neutropenia due to HAX1 deficiency.
Matsubara K; Imai K; Okada S; Miki M; Ishikawa N; Tsumura M; Kato T; Ohara O; Nonoyama S; Kobayashi M
Haematologica, 92(12), e123-5, Dec. 2007, Refereed, Not invited
Lead - Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells
Atsushi Hijikata; Hiroshi Kitamura; Yayoi Kimura; Ryo Yokoyama; Yuichi Aiba; Yanyuan Bao; Shigeharu Fujita; Koji Hase; Shohei Hori; Yasuyuki Ishii; Osami Kanagawa; Hiroshi Kawamoto; Kazuya Kawano; Haruhiko Koseki; Masato Kubo; Ai Kurita-Miki; Tomohiro Kurosaki; Kyoko Masuda; Mitsumasa Nakata; Keisuke Oboki; Hiroshi Ohno; Mariko Okamoto; Yoshimichi Okayama; Jiyang O-Wang; Hirohisa Saito; Takashi Saito; Machie Sakuma; Katsuaki Sato; Kaori Sato; Ken-Ichiro Seino; Ruka Setoguchi; Yuki Tamura; Masato Tanaka; Masaru Taniguchi; Ichiro Taniuchi; Annabelle Teng; Takeshi Watanabe; Hiroshi Watarai; Sho Yamasaki; Osamu Ohara
BIOINFORMATICS, 23(21), 2934-2941, Nov. 2007, Refereed, Not invited
Lead - Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region
Fumihiko Ishikawa; Shuro Yoshida; Yoriko Saito; Atsushi Hijikata; Hiroshi Kitamura; Satoshi Tanaka; Ryu Nakamura; Toru Tanaka; Hiroko Tomiyama; Noriyuki Saito; Mitsuhiro Fukata; Toshihiro Miyamoto; Bonnie Lyons; Koichi Ohshima; Naoyuki Uchida; Shuichi Taniguchi; Osamu Ohara; Koichi Akashi; Mine Harada; Leonard D. Shultz
NATURE BIOTECHNOLOGY, 25(11), 1315-1321, Nov. 2007, Refereed, Not invited
Lead - Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system
Motoaki Wakiyama; Koji Takimoto; Osamu Ohara; Shigeyuki Yokoyama
GENES & DEVELOPMENT, 21(15), 1857-1862, Aug. 2007, Refereed, Not invited
Lead - 5 : Topics III on Cell Control Problem Regulation of the Immune System and Its Analysis
OHARA Osamu
Journal of The Society of Instrument and Control Engineers, 46(6), 493-499, Jun. 2007
Lead - Structural and functional differences of SWIRM domain subtypes
Misao Yoneyama; Naoya Tochio; Takashi Umehara; Seizo Koshiba; Makoto Inoue; Takashi Yabuki; Masaaki Aoki; Eiko Seki; Takayoshi Matsuda; Satoru Watanabe; Yasuko Tomo; Yuji Nishimura; Takushi Harada; Takaho Terada; Mikako Shirouzu; Yoshihide Hayashizaki; Osamu Ohara; Akiko Tanaka; Takanori Kigawa; Shigeyuki Yokoyama
JOURNAL OF MOLECULAR BIOLOGY, 369(1), 222-238, May 2007, Refereed, Not invited
Lead - Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes
Yuki Takada; Kyo-ichi Isono; Jun Shinga; James M. A. Turner; Hiroshi Kitamura; Osamu Ohara; Gen Watanabe; Prim B. Singh; Takehiko Kamijo; Thomas Jenuwein; Paul S. Burgoyne; Haruhiko Koseki
DEVELOPMENT, 134(3), 579-590, Feb. 2007, Refereed, Not invited
Lead - Novel regulation of MHC class II function in B cells
Yohei Matsuki; Mari Ohmura-Hoshino; Eiji Goto; Masami Aoki; Mari Mito-Yoshida; Mika Uematsu; Takanori Hasegawa; Haruhiko Koseki; Osamu Ohara; Manabu Nakayama; Kiminori Toyooka; Ken Matsuoka; Hak Hotta; Akitsugu Yamamoto; Satoshi Ishido
EMBO JOURNAL, 26(3), 846-854, Feb. 2007, Refereed, Not invited
Lead - IL-21-induced B epsilon cell apoptosis mediated by natural killer T cells suppresses IgE responses
Michishige Harada; Kumiko Magara-Koyanagi; Hiroshi Watarai; Yuko Nagata; Yasuyuki Ishii; Satoshi Kojo; Shigetoshi Horiguchi; Yoshitaka Okamoto; Toshinori Nakayama; Nobutaka Suzuki; Wen-Chen Yeh; Shizuo Akira; Hiroshi Kitamura; Osamu Ohara; Ken-ichiro Seino; Masaru Taniguchi
JOURNAL OF EXPERIMENTAL MEDICINE, 203(13), 2929-2937, Dec. 2006, Refereed, Not invited
Lead - Absence of DNA polymerase theta results in decreased somatic hypermutation frequency and altered mutation patterns in Ig
Keiji Masuda; Rika Ouchida; Masaki Hikida; Manabu Nakayama; Osamu Ohara; Tomohiro Kurosaki; Jiyanq O-Wang
DNA REPAIR, 5(11), 1384-1391, Nov. 2006, Refereed, Not invited
Lead - Expression of protein 4.1G in Schwann cells of the peripheral nervous system
Nobuhiko Ohno; Nobuo Terada; Hisashi Yamakawa; Masayuki Komada; Osamu Ohara; Bruce D. Trapp; Shinichi Ohno
JOURNAL OF NEUROSCIENCE RESEARCH, 84(3), 568-577, Aug. 2006, Refereed, Not invited
Lead - A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins
Manabu Nakayama; Midori Iida; Haruhiko Koseki; Osamu Ohara
FASEB JOURNAL, 20(10), 1718-+, Aug. 2006, Refereed, Not invited
Lead - Construction of quantitative proteome reference maps of mouse spleen and lymph node based on two-dimensional gel electrophoresis
Yayoi Kimura; Ryo Yokoyama; Yuri Ishizu; Toshio Nishigaki; Yasuaki Murahashi; Atsushi Hijikata; Hiroshi Kitamura; Osamu Ohara
PROTEOMICS, 6(13), 3833-3844, Jul. 2006, Refereed, Not invited
Lead - I kappa B kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9
K Hoshino; T Sugiyama; M Matsumoto; T Tanaka; M Saito; H Hemmi; O Ohara; S Akira; T Kaisho
NATURE, 440(7086), 949-953, Apr. 2006, Refereed, Not invited
Lead - Solution structure of the SWIRM domain of human histone demethylase LSD1
N Tochio; T Umehara; S Koshiba; M Inoue; T Yabuki; M Aoki; E Seki; S Watanabe; Y Tomo; M Hanada; M Ikari; M Sato; T Terada; T Nagase; O Ohara; M Shirouzu; A Tanaka; T Kigawa; S Yokoyama
STRUCTURE, 14(3), 457-468, Mar. 2006, Refereed, Not invited
Lead - Kazusa mammalian cDNA resources: Towards functional characterization of KIAA gene products
Takahiro Nagase; Hisashi Koga; Osamu Ohara
Briefings in Functional Genomics and Proteomics, 5(1), 4-7, Mar. 2006, Refereed, Not invited
Lead - Development of a microscopic platform for real-time monitoring of biomolecular interactions
Y Sasuga; T Tani; M Hayashi; H Yamakawa; O Ohara; Y Harada
GENOME RESEARCH, 16(1), 132-139, Jan. 2006, Refereed, Not invited
Lead - Chromatographic Analysis of Suberimidate-Crosslinked Lysine
Osamu Ohara
Journal of Liquid Chromatography, 2006
Lead - 2P525 Development of a microscopic platform for single-cell analyses using picoliter microwell array(52. Bio-imaging,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
Sasuga Yasuhiro; Iwasawa Tomoyuki; Terada Kayoko; Sorimachi Hiroyuki; Ohara Osamu; Harada Yoshie
Seibutsu Butsuri, 46(2), S427, 2006
Lead - 2P442 RefDIC : Construction of an open-access database of the quantitative transcriptome and proteome data of immune cells(48. Bioinformatics, genomics and proteomics (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
Hijikata Atsushi; Kitamura Hiroshi; Kimura Yayoi; Yokoyama Ryo; RCAI RefDIC supporting group; Ohara Osamu
Seibutsu Butsuri, 46(2), S406, 2006
Lead - Gene: Preface
Osamu Ohara; Katheleen Gardiner
Gene, 364(1-2), 1, Dec. 2005, Refereed, Not invited
Lead - Temporal change in mKIAA gene expression during the early stage of retinoic acid-induced neurite outgrowth
K Imai; M Kawai; M Tada; T Nagase; O Ohara; H Koga
GENE, 364, 114-122, Dec. 2005, Refereed, Not invited
Lead - Protein 4.1 G localizes in rodent microglia
N Ohno; N Terada; J Tanaka; A Yokoyama; H Yamakawa; Y Fujii; T Baba; O Ohara; S Ohno
HISTOCHEMISTRY AND CELL BIOLOGY, 124(6), 477-486, Dec. 2005, Refereed, Not invited
Lead - High incidence of NLRP3 somatic mosaicism in patients with chronic infantile neurologic, cutaneous, articular syndrome: Results of an international multicenter collaborative study
Tanaka N; Izawa K; Saito MK; Sakuma M; Oshima K; Ohara O; Nishikomori R; Morimoto T; Kambe N; Goldbach-Mansky R; Aksentijevich I; de Saint; Basile G; Neven B; van Gijn M; Frenkel J; Aróstegui JI; Yagüe J; Merino R; Ibañez M; Pontillo A; Takada H; Imagawa T; Kawai T; Yasumi T; Nakahata T; Heike T
Arthritis Rheum 63(3625-3632), Nov. 2005, Refereed, Not invited
Lead - Utilization of mammalian cells for efficient and reliable evaluation of specificity of antibodies to unravel the cellular function of mKIAA proteins
A Ozaki; T Nagase; A Watanabe; D Nakajima; K Shimada; M Nagano; O Ohara; H Koga; S Inamoto
GENE, 360(1), 35-44, Oct. 2005, Refereed, Not invited
Lead - V alpha 14 NKT cell-triggered IFN-gamma production by Gr-1(+)CD11b(+) cells mediates early graft loss of syngeneic transplanted islets
Y Yasunami; S Kojo; H Kitamura; A Toyofuku; M Satoh; M Nakano; K Nabeyama; Y Nakamura; N Matsuoka; S Ikeda; M Tanaka; J Ono; N Nagata; O Ohara; M Taniguchi
JOURNAL OF EXPERIMENTAL MEDICINE, 202(7), 913-918, Oct. 2005, Refereed, Not invited
Lead - Immunohistochemical study of a membrane skeletal molecule, protein 4.1G, in mouse seminiferous tubules
N Terada; N Ohno; H Yamakawa; O Ohara; XG Liao; T Baba; S Ohno
HISTOCHEMISTRY AND CELL BIOLOGY, 124(3-4), 303-311, Sep. 2005, Refereed, Not invited
Lead - The transcriptional landscape of the mammalian genome
P Carninci; T Kasukawa; S Katayama; J Gough; MC Frith; N Maeda; R Oyama; T Ravasi; B Lenhard; C Wells; R Kodzius; K Shimokawa; VB Bajic; SE Brenner; S Batalov; ARR Forrest; M Zavolan; MJ Davis; LG Wilming; Aidinis, V; JE Allen; Ambesi-Impiombato, X; R Apweiler; RN Aturaliya; TL Bailey; M Bansal; L Baxter; KW Beisel; T Bersano; H Bono; AM Chalk; KP Chiu; Choudhary, V; A Christoffels; DR Clutterbuck; ML Crowe; E Dalla; BP Dalrymple; B de Bono; G Della Gatta; D di Bernardo; T Down; P Engstrom; M Fagiolini; G Faulkner; CF Fletcher; T Fukushima; M Furuno; S Futaki; M Gariboldi; P Georgii-Hemming; TR Gingeras; T Gojobori; RE Green; S Gustincich; M Harbers; Y Hayashi; TK Hensch; N Hirokawa; D Hill; L Huminiecki; M Iacono; K Ikeo; A Iwama; T Ishikawa; M Jakt; A Kanapin; M Katoh; Y Kawasawa; J Kelso; H Kitamura; H Kitano; G Kollias; SPT Krishnan; A Kruger; SK Kummerfeld; Kurochkin, IV; LF Lareau; D Lazarevic; L Lipovich; J Liu; S Liuni; S McWilliam; MM Babu; M Madera; L Marchionni; H Matsuda; S Matsuzawa; H Miki; F Mignone; S Miyake; K Morris; S Mottagui-Tabar; N Mulder; N Nakano; H Nakauchi; P Ng; R Nilsson; S Nishiguchi; S Nishikawa; F Nori; O Ohara; Y Okazaki; Orlando, V; KC Pang; WJ Pavan; G Pavesi; G Pesole; N Petrovsky; S Piazza; J Reed; JF Reid; BZ Ring; M Ringwald; B Rost; Y Ruan; SL Salzberg; A Sandelin; C Schneider; C Schonbach; K Sekiguchi; CAM Semple; S Seno; L Sessa; Y Sheng; Y Shibata; H Shimada; K Shimada; D Silva; B Sinclair; S Sperling; E Stupka; K Sugiura; R Sultana; Y Takenaka; K Taki; K Tammoja; SL Tan; S Tang; MS Taylor; J Tegner; SA Teichmann; HR Ueda; E van Nimwegen; R Verardo; CL Wei; K Yagi; H Yamanishi; E Zabarovsky; S Zhu; A Zimmer; W Hide; C Bult; SM Grimmond; RD Teasdale; ET Liu; Brusic, V; J Quackenbush; C Wahlestedt; JS Mattick; DA Hume; C Kai; D Sasaki; Y Tomaru; S Fukuda; M Kanamori-Katayama; M Suzuki; J Aoki; T Arakawa; J Iida; K Imamura; M Itoh; T Kato; H Kawaji; N Kawagashira; T Kawashima; M Kojima; S Kondo; H Konno; K Nakano; N Ninomiya; T Nishio; M Okada; C Plessy; K Shibata; T Shiraki; S Suzuki; M Tagami; K Waki; A Watahiki; Y Okamura-Oho; H Suzuki; J Kawai; Y Hayashizaki
SCIENCE, 309(5740), 1559-1563, Sep. 2005, Refereed, Not invited
Lead - Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method
Daisuke Nakajima; Kenji Saito; Hisashi Yamakawa; Reiko F. Kikuno; Manabu Nakayama; Reiko Ohara; Noriko Okazaki; Hisashi Koga; Takahiro Nagase; Osamu Ohara
DNA RESEARCH, 12(4), 257-267, Aug. 2005, Refereed, Not invited
Lead - Interaction of myosin VI with a transmembrane Ser/Thr kinase KPI-2
O. Takeshi Inoue; Takahide Kon; Reiko Ohkura; Hisashi Yamakawa; Osamu Ohara; Jun Yokota; Kazuo Sutoh
CELL STRUCTURE AND FUNCTION, 30, 72-72, Jun. 2005, Refereed, Not invited
Lead - Topographical significance of membrane skeletal component protein 4.1B in mammalian organs
Nobuo Terada; Nobuhiko Ohno; Hisashi Yamakawa; Osamu Ohara; Shinichi Ohno
Anatomical Science International, 80(2), 61-70, Jun. 2005, Refereed, Not invited
Lead - Improvement of recombination efficiency by mutation of Red proteins
M Nakayama; O Ohara
BIOTECHNIQUES, 38(6), 917-924, Jun. 2005, Refereed, Not invited
Lead - The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site
Y Isogawa; T Kon; T Inoue; R Ohkura; H Yamakawa; O Ohara; K Sutoh
BIOCHEMISTRY, 44(16), 6190-6196, Apr. 2005, Refereed, Not invited
Lead - cDNA library construction from a small amount of RNA: adaptor-ligation approach for two-round cRNA amplification using T7 and SP6 RNA polymerases
R Ohara; RF Kikuno; H Kitamura; O Ohara
BIOTECHNIQUES, 38(3), 451-458, Mar. 2005, Refereed, Not invited
Lead - Electrophoretic deposition of a high performance La(Sr)Ga(Mg)O3 electrolyte film for a low temperature solid oxide fuel cell
Osamu Ohara
Ceramic Transactions, 2005
Lead - 2P194 Single molecule observation of ATP hydrolysis of Myosin V
Komori T.; Nishikawa S.; Ariga T.; Iwane A.H.; Yamakawa H.; Ohara O.; Yanagida T.
Seibutsu Butsuri, 45, S168, 2005
Lead - 1P333 Protein expression profiling for single-cell using microbead array technology
Sasuga Y.; Terada K.; Tani T.; Ohara O.; Harada Y.
Seibutsu Butsuri, 45, S115, 2005
Lead - Influence of the 3′-UTR-length of mKIAA cDNAs and their sequence features to the mRNA expression level in the brain
Okazaki, N.; Imai, K.; Kikuno, R.F.; Misawa, K.; Kawai, M.; Inamoto, S.; Ohara, R.; Nagase, T.; Ohara, O.; Koga, H.
DNA Research, 12(3), 181-189, 2005, Refereed, Not invited
Lead - Immunolocalization of protein 4.1B/DAL-1 during neoplastic transformation of mouse and human intestinal epithelium
N Ohno; N Terada; S Murata; H Yamakawa; IF Newsham; R Katoh; O Ohara; S Ohno
HISTOCHEMISTRY AND CELL BIOLOGY, 122(6), 579-586, Dec. 2004, Refereed, Not invited
Lead - Post-transcriptional effects of phorbol 12-myristate 13-acetate on transcriptome of U937 cells
H Kitamura; T Nakagawa; M Takayama; Y Kimura; A Hijika; O Ohara
FEBS LETTERS, 578(1-2), 180-184, Dec. 2004, Refereed, Not invited
Lead - Alternative splice variants encoding unstable protein domains exist in the human brain
K Homma; RF Kikuno; T Nagase; O Ohara; K Nishikawa
JOURNAL OF MOLECULAR BIOLOGY, 343(5), 1207-1220, Nov. 2004, Refereed, Not invited
Lead - Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray
M Nishimura; N Yokoi; T Miki; Y Horikawa; H Yoshioka; J Takeda; O Ohara; S Seino
DNA RESEARCH, 11(5), 315-323, Oct. 2004, Refereed, Not invited
Lead - A simple and robust method for preparation of cDNA nylon microarrays
H Yamakawa; S Yokoyama; T Hirano; H Kitamura; O Ohara
DNA RESEARCH, 11(5), 353-360, Oct. 2004, Refereed, Not invited
Lead - The CAP-Gly domain with the proline-rich of CYLD associates sequence in NEMO/IKK gamma
K Saito; T Kigawa; S Koshiba; K Sato; Y Matsuo; A Sakamoto; T Takagi; M Shirouzu; T Yabuki; E Nunokawa; E Seki; T Matsuda; M Aoki; Y Miyata; N Hirakawa; M Inoue; T Terada; T Nagase; R Kikuno; M Nakayama; O Ohara; A Tanaka; S Yokoyama
STRUCTURE, 12(9), 1719-1728, Sep. 2004, Refereed, Not invited
Lead - Protein 4.1B localizes on unmyelinated axonal membranes in the mouse enteric nervous system
N Terada; N Ohno; H Yamakawa; T Baba; Y Fujii; O Ohara; S Ohno
NEUROSCIENCE LETTERS, 366(1), 15-17, Aug. 2004, Refereed, Not invited
Lead - [Preparation of DNA and RNA].
Kitamura H; Nagase T; Ohara O
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 49(11 Suppl), 1469-1475, Aug. 2004, Refereed, Not invited
Lead - A comprehensive approach for establishment of the platform to analyze functions of KIAA proteins II: Public release of inaugural version of InGaP database containing gene/protein expression profiles for 127 mouse KIAA genes/proteins
H Koga; S Yuasa; T Nagase; K Shimada; M Nagano; K Imai; R Ohara; D Nakajima; M Murakami; M Kawai; F Miki; J Magae; S Inamoto; N Okazaki; O Ohara
DNA RESEARCH, 11(4), 293-304, Aug. 2004, Refereed, Not invited
Lead - Mutations affecting thymus organogenesis in Medaka, Oryzias latipes
N Iwanami; Y Takahama; S Kunimatsu; H Li; R Takei; Y Ishikura; H Suwa; K Niwa; T Sasado; C Morinaga; A Yasuoka; T Deguchi; Y Hirose; H Yoda; T Henrich; O Ohara; H Kondoh; M Furutani-Seiki
MECHANISMS OF DEVELOPMENT, 121(7-8), 779-789, Jul. 2004, Refereed, Not invited
Lead - Immunohistochemical study of protein 4.1B in the normal and W/W(v) mouse seminiferous epithelium.
Terada N; Ohno N; Yamakawa H; Baba T; Fujii Y; Zea Z; Ohara O; Ohno S
Journal of Histochemistry & Cytochemistry, Jun. 2004
Lead - Immunohistochemical study of protein 4.1 beta in the normal and W/W-v mouse seminiferous epithelium
N Terada; N Ohno; H Yamakawa; T Baba; Y Fujii; Z Zea; O Ohara; S Ohno
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 52(6), 769-777, Jun. 2004, Refereed, Not invited
Lead - Isolation from cochlea of a novel human intronless gene with predominant fetal expression
BL Resendes; SF Kuo; NG Robertson; ABS Giersch; D Honrubia; O Ohara; JC Adams; CC Morton
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY, 5(2), 185-202, Jun. 2004, Refereed, Not invited
Lead - Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries
N Okazaki; R F-Kikuno; R Ohara; S Inamoto; H Koseki; S Hiraoka; Y Saga; S Seino; M Nishimura; T Kaisho; K Hoshino; H Kitamura; T Nagase; O Ohara; H Koga
DNA RESEARCH, 11(3), 205-218, Jun. 2004, Refereed, Not invited
Lead - The PDZ domain of Myo18A has actin-binding activity
Yasushi Isogawa; Takahide Kon; Takeshi Inoue; Kenji Imamura; Reiko Ohkura; Hisashi Yamakawa; Osamu Ohara; Kazuo Sutoh
CELL STRUCTURE AND FUNCTION, 29, 19-19, May 2004, Refereed, Not invited
Lead - Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts
K Miyazaki; T Nagase; M Mesaki; J Narukawa; O Ohara; N Ishida
BIOCHEMICAL JOURNAL, 380(Pt 1), 95-103, May 2004, Refereed, Not invited
Lead - Method for systematic targeted isolation of homologous cDNA fragments in a multiplex format
R Ohara; H Koga; R Kikuno; O Ohara
BIOTECHNIQUES, 36(5), 798-+, May 2004, Refereed, Not invited
Lead - A comprehensive approach for establishment of the platform to analyze functions of KIAA proteins: Generation and evaluation of anti-mKIAA antibodies
H Koga; K Shimada; Y Hara; M Nagan; H Kohga; R Yokoyama; Y Kimura; S Yuasa; J Magae; S Inamoto; N Okazaki; O Ohara
PROTEOMICS, 4(5), 1412-1416, May 2004, Refereed, Not invited
Lead - Immunolocalization of protein 4.1B in the rat digestive system
N Terada; N Ohno; H Yamakawa; T Baba; Y Fujii; O Ohara; S Ohno
JOURNAL OF MOLECULAR HISTOLOGY, 35(4), 347-353, May 2004, Refereed, Not invited
Lead - Prediction of the coding sequences of mouse homologues of FLJ genes: The complete nucleotide sequences of 110 mouse FLJ-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries
N Okazaki; R Kikuno; R Ohara; S Inamoto; H Koseki; S Hiraoka; Y Saga; H Kitamura; T Nakagawa; T Nagase; O Ohara; H Koga
DNA RESEARCH, 11(2), 127-135, Apr. 2004, Refereed, Not invited
Lead - SigC, the group 2 sigma factor of RNA polymerase, contributes to the late-stage gene expression and nitrogen promoter recognition in the cyanobacterium Synechocystis sp strain PCC 6803
M Asayama; S Imamura; S Yoshihara; A Miyazaki; N Yoshida; T Sazuka; T Kaneko; O Ohara; S Tabata; T Osanai; K Tanaka; H Takahashi; M Shirai
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 68(3), 477-487, Mar. 2004, Refereed, Not invited
Lead - Immunoelectron microscopic localization of protein 4.1B in proximal S1 and S2 tubules of rodent kidneys
Nobuo Terada; Nobuhiko Ohno; Hisashi Yamakawa; George Seki; Yasuhisa Fujii; Takeshi Baba; Osamu Ohara; Shinichi Ohno
Medical Electron Microscopy, 37(1), 45-51, Mar. 2004, Refereed, Not invited
Lead - HUGE: a database for human KIAA proteins, a 2004 update integrating HUGEppi and ROUGE
R Kikuno; T Nagase; M Nakayama; H Koga; N Okazaki; D Nakajima; O Ohara
NUCLEIC ACIDS RESEARCH, 32(Database issue), D502-D504, Jan. 2004, Refereed, Not invited
Lead - Complete sequencing and characterization of 21,243 full-length human cDNAs
T Ota; Y Suzuki; T Nishikawa; T Otsuki; T Sugiyama; R Irie; A Wakamatsu; K Hayashi; H Sato; K Nagai; K Kimura; H Makita; M Sekine; M Obayashi; T Nishi; T Shibahara; T Tanaka; S Ishii; J Yamamoto; K Saito; Y Kawai; Y Isono; Y Nakamura; K Nagahari; K Murakami; T Yasuda; T Iwayanagi; M Wagatsuma; A Shiratori; H Sudo; T Hosoiri; Y Kaku; H Kodaira; H Kondo; M Sugawara; M Takahashi; K Kanda; T Yokoi; T Furuya; E Kikkawa; Y Omura; K Abe; K Kamihara; N Katsuta; K Sato; M Tanikawa; M Yamazaki; K Ninomiya; T Ishibashi; H Yamashita; K Murakawa; K Fujimori; H Tanai; M Kimata; M Watanabe; S Hiraoka; Y Chiba; S Ishida; Y Ono; S Takiguchi; S Watanabe; M Yosida; T Hotuta; J Kusano; K Kanehori; A Takahashi-Fujii; H Hara; T Tanase; Y Nomura; S Togiya; F Komai; R Hara; K Takeuchi; M Arita; N Imose; K Musashino; H Yuuki; A Oshima; N Sasaki; S Aotsuka; Y Yoshikawa; H Matsunawa; T Ichihara; N Shiohata; S Sano; S Moriya; H Momiyama; N Satoh; S Takami; Y Terashima; O Suzuki; S Nakagawa; A Senoh; H Mizoguchi; Y Goto; F Shimizu; H Wakebe; H Hishigaki; T Watanabe; A Sugiyama; M Takemoto; B Kawakami; M Yamazaki; K Watanabe; A Kumagai; S Itakura; Y Fukuzumi; Y Fujimori; M Komiyama; H Tashiro; A Tanigami; T Fujiwara; T Ono; K Yamada; Y Fujii; K Ozaki; M Hirao; Y Ohmori; A Kawabata; T Hikiji; N Kobatake; H Inagaki; Y Ikema; S Okamoto; R Okitani; T Kawakami; S Noguchi; T Itoh; K Shigeta; T Senba; K Matsumura; Y Nakajima; T Mizuno; M Morinaga; M Sasaki; T Togashi; M Oyama; H Hata; M Watanabe; T Komatsu; J Mizushima-Sugano; T Satoh; Y Shirai; Y Takahashi; K Nakagawa; K Okumura; T Nagase; N Nomura; H Kikuchi; Y Masuho; R Yamashita; K Nakai; T Yada; Y Nakamura; O Ohara; T Isogai; S Sugano
NATURE GENETICS, 36(1), 40-45, Jan. 2004, Refereed, Not invited
Lead - Effect of a topical steroid on gene expressions for chemokines in mice with contact hypersensitivity
G Mitsui; T Hirano; Y Niwano; K Mitsui; O Ohara; S Yanagihara; M Kato
INTERNATIONAL IMMUNOPHARMACOLOGY, 4(1), 57-69, Jan. 2004, Refereed, Not invited
Lead - The effects of outgrowth of neurites and adhesive repulsion by cultured vascular sooth muscle cells
Osamu Ohara
Zoological Science, 2004
Lead - 2P278 Development of the molecular interaction analysis system using microbeads array
Sasuga Y.; Ohara O.; Tani T.; Harada Y.
Seibutsu Butsuri, 44, S179, 2004
Lead - Integrative annotation of 21,037 human genes validated by full-length cDNA clones
Tadashi Imanishi; Takeshi Itoh; Yutaka Suzuki; Claire O'Donovan; Satoshi Fukuchi; Kanako O. Koyanagi; Roberto A. Barrero; Takuro Tamura; Yumi Yamaguchi-Kabata; Motohiko Tanino; Kei Yura; Satoru Miyazaki; Kazuho Ikeo; Keiichi Homma; Arek Kasprzyk; Tetsuo Nishikawa; Mika Hirakawa; Jean Thierry-Mieg; Danielle Thierry-Mieg; Jennifer Ashurst; Libin Jia; Mitsuteru Nakao; Michael A. Thomas; Nicola Mulder; Youla Karavidopoulou; Lihua Jin; Sangsoo Kim; Tomohiro Yasuda; Boris Lenhard; Eric Eveno; Yoshiyuki Suzuki; Chisato Yamasaki; Jun-Ichi Takeda; Craig Gough; Phillip Hilton; Yasuyuki Fujii; Hiroaki Sakai; Susumu Tanaka; Clara Amid; Matthew Bellgard; Maria de Fatima Bonaldo; Hidemasa Bono; Susan K. Bromberg; Anthony J. Brookes; Elspeth Bruford; Piero Carninci; Claude Chelala; Christine Couillault; Sandro J. de Souza; Marie-Anne Debily; Marie-Dominique Devignes; Inna Dubchak; Toshinori Endo; Anne Estreicher; Eduardo Eyras; Kaoru Fukami-Kobayashi; Gopal R. Gopinath; Esther Graudens; Yoonsoo Hahn; Michael Han; Ze-Guang Han; Kousuke Hanada; Hideki Hanaoka; Erimi Harada; Katsuyuki Hashimoto; Ursula Hinz; Momoki Hirai; Teruyoshi Hishiki; Ian Hopkinson; Sandrine Imbeaud; Hidetoshi Inoko; Alexander Kanapin; Yayoi Kaneko; Takeya Kasukawa; Janet Kelso; Paul Kersey; Reiko Kikuno; Kouichi Kimura; Bernhard Korn; Vladimir Kuryshev; Izabela Makalowska; Takashi Makino; Shuhei Mano; Regine Mariage-Samson; Jun Mashima; Hideo Matsuda; Hans-Werner Mewes; Shinsei Minoshima; Keiichi Nagai; Hideki Nagasaki; Naoki Nagata; Rajni Nigam; Osamu Ogasawara; Osamu Ohara; Masafumi Ohtsubo; Norihiro Okada; Toshihisa Okido; Satoshi Oota; Motonori Ota; Toshio Ota; Tetsuji Otsuki; Dominique Piatier-Tonneau; Annemarie Poustka; Shuang-Xi Ren; Naruya Saitou; Katsunaga Sakai; Shigetaka Sakamoto; Ryuichi Sakate; Ingo Schupp; Florence Servant; Stephen Sherry; Rie Shiba; Nobuyoshi Shimizu; Mary Shimoyama; Andrew J. Simpson; Bento Soares; Charles Steward; Makiko Suwa; Mami Suzuki; Aiko Takahashi; Gen Tamiya; Hiroshi Tanaka; Todd Taylor; Joseph D. Terwilliger; Per Unneberg; Vamsi Veeramachaneni; Shinya Watanabe; Laurens Wilming; Norikazu Yasuda; Sook Hyang-Yoo; Marvin Stodolsky; Wojciech Makalowski; Mitiko Go; Kenta Nakai; Toshihisa Takagi; Minoru Kanehisa; Yoshiyuki Sakaki; John Quackenbush; Yasushi Okazaki; Yoshihide Hayashizaki; Winston Hide; Ranajit Chakraborty; Ken Nishikawa; Hideaki Sugawara; Yoshio Tateno; Zhu Chen; Michio Oishi; Peter Tonellato; Rolf Apweiler; Kousaku Okubo; Lukas Wagner; Stefan Wiemann; Robert L. Strausberg; Takao Isogai; Charles Auffray; Nobuo Nomura; Takashi Gojobori; Sumio Sugano
PLoS Biology, 2(6), e162, 2004, Refereed, Not invited
Lead - Human ATP-binding cassette transporter ABCC10: Expression profile and p53-dependent upregulation
Shin-Ichiro Takayanagi; Takao Kataoka; Osamu Ohara; Michio Oishi; M. Tien Kuo; Toshihisa Ishikawa
Journal of Experimental Therapeutics and Oncology, 4(3), 239-246, 2004, Refereed, Not invited
Lead - Expression profile of mRNAs from human pancreatic islet tumors
L Jin; H Wang; T Narita; R Kikuno; O Ohara; N Shihara; T Nishigori; Y Horikawa; J Takeda
JOURNAL OF MOLECULAR ENDOCRINOLOGY, 31(3), 519-528, Dec. 2003, Refereed, Not invited
Lead - A system using convertible vectors for screening soluble recombinant proteins produced in Escherichia coli from randomly fragmented cDNAs
M Nakayama; O Ohara
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 312(3), 825-830, Dec. 2003, Refereed, Not invited
Lead - Protein 4.1B in mouse islets of Langerhans and beta-cell tumorigenesis
N Terada; N Ohno; H Yamakawa; T Baba; Y Fujii; G Christofori; O Ohara; S Ohno
HISTOCHEMISTRY AND CELL BIOLOGY, 120(4), 277-283, Oct. 2003, Refereed, Not invited
Lead - The Kazusa cDNA project for identification of unknown human transcripts
T Nagase; R Kikuno; O Ohara
COMPTES RENDUS BIOLOGIES, 326(10-11), 959-966, Oct. 2003, Refereed, Not invited
Lead - Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries
N Okazaki; R Kikuno; R Ohara; S Inamoto; H Koseki; S Hiraoka; Y Saga; T Nagase; O Ohara; H Koga
DNA RESEARCH, 10(4), 167-180, Aug. 2003, Refereed, Not invited
Lead - Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain
M Yoshizawa; M Sone; N Matsuo; T Nagase; O Ohara; Y Nabeshima; M Hoshino
GENE EXPRESSION PATTERNS, 3(3), 375-381, Jun. 2003, Refereed, Not invited
Lead - High-throughput production of recombinant antigens for mouse KIAA proteins in Escherichia coli: Computational allocation of possible antigenic regions, and construction of expression plasmids of glutathione-S-transferase-fused antigens by an in vitro recombination-assisted method
Y Hara; Shimada, I; H Kohga; O Ohara; H Koga
DNA RESEARCH, 10(3), 129-136, Jun. 2003, Refereed, Not invited
Lead - Kinetic profiles of sequential gene expressions for chemokines in mice with contact hypersensitivity
G Mitsui; K Mitsui; T Hirano; O Ohara; M Kato; Y Niwano
IMMUNOLOGY LETTERS, 86(2), 191-197, Apr. 2003, Refereed, Not invited
Lead - DomCut: prediction of inter-domain linker regions in amino acid sequences
M Suyama; O Ohara
BIOINFORMATICS, 19(5), 673-674, Mar. 2003, Refereed, Not invited
Lead - Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries
N Okazaki; R Kikuno; R Ohara; S Inamoto; H Aizawa; S Yuasa; D Nakajima; T Nagase; O Ohara; H Koga
DNA RESEARCH, 10(1), 35-48, Feb. 2003, Refereed, Not invited
Lead - Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones
H Jikuya; J Takano; R Kikuno; M Hirosawa; T Nagase; N Nomura; O Ohara
DNA RESEARCH, 10(1), 49-57, Feb. 2003, Refereed, Not invited
Lead - Protein 4.1B associates with both Caspr/paranodin and Caspr2 at paranodes and juxtaparanodes of myelinated fibres
N Denisenko-Nehrbass; K Oguievetskaia; L Goutebroze; T Galvez; H Yamakawa; O Ohara; M Carnaud; JA Girault
EUROPEAN JOURNAL OF NEUROSCIENCE, 17(2), 411-416, Jan. 2003, Refereed, Not invited
Lead - Characterization of human Smg5/7a: A protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1
SY Chiu; G Serin; O Ohara; LE Maquat
RNA-A PUBLICATION OF THE RNA SOCIETY, 9(1), 77-87, Jan. 2003, Refereed, Not invited
Lead - Electrophoretic fabrication and cell performance of dense Sr- and Mg-doped LaGaO3-based electrolyte films
Osamu Ohara
Electrochemical and Solid-State Letters, 2003
Lead - Fanctional analysis of Myo18A
Isogawa Y.; Kon T.; Inoue T.; Ohkura R.; Yamakawa O.; Ohara O.; Sutoh K.
Seibutsu Butsuri, 43, S145, 2003
Lead - Construction of size-fractionated cDNA library assisted by an in vitro recombination reaction.
Ohara O
Methods in molecular biology (Clifton, N.J.), 221, 59-71, 2003, Refereed, Not invited
Lead - Characterization of mammalian synemin, an intermediate filament protein present in all four classes of muscle cells and some neuroglial cells: co-localization and interaction with type III intermediate filament proteins and keratins
Y Hirako; H Yamakawa; Y Tsujimura; Y Nishizawa; M Okumura; J Usukura; H Matsumoto; KW Jackson; K Owaribe; O Ohara
CELL AND TISSUE RESEARCH, 313(2), 195-207, 2003, Refereed, Not invited
Lead - Protein-protein interactions between large proteins: Two-hybrid screening using a functionally classified library composed of long cDNAs
M Nakayama; R Kikuno; O Ohara
GENOME RESEARCH, 12(11), 1773-1784, Nov. 2002, Refereed, Not invited
Lead - Cloning of a novel phosphotyrosine binding domain containing molecule, Odin, involved in signaling by receptor tyrosine kinases
A Pandey; B Blagoev; Kratchmarova, I; M Fernandez; M Nielsen; TZ Kristiansen; O Ohara; AV Podtelejnikov; S Roche; HF Lodish; M Mann
ONCOGENE, 21(52), 8029-8036, Nov. 2002, Refereed, Not invited
Lead - Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries
N Okazaki; R Kikuno; R Ohara; S Inamoto; Y Hara; T Nagase; O Ohara; H Koga
DNA RESEARCH, 9(5), 179-188, Oct. 2002, Refereed, Not invited
Lead - MEGF1/fat2 proteins containing extraordinarily large extracellular domains are localized to thin parallel fibers of cerebellar granule cells
M Nakayama; D Nakajima; R Yoshimura; Y Endo; O Ohara
MOLECULAR AND CELLULAR NEUROSCIENCE, 20(4), 563-578, Aug. 2002, Refereed, Not invited
Lead - A mass spectrometry-based proteomic approach for identification of serine/threonine-phosphorylated proteins by enrichment with phospho-specific antibodies - Identification of a novel protein, Frigg, as a protein kinase A substrate
M Gronborg; TZ Kristiansen; A Stensballe; JS Andersen; O Ohara; M Mann; ON Jensen; A Pandey
MOLECULAR & CELLULAR PROTEOMICS, 1(7), 517-527, Jul. 2002, Refereed, Not invited
Lead - [Comprehensive analysis of human large cDNAs which directs the synthesis of large proteins].
Ohara O; Nagase T; Kikuno R; Oishi M
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 47(8 Suppl), 991-996, Jun. 2002, Refereed, Not invited
Lead - Construction of expression-ready cDNA clones for KIAA genes: Manual curation of 330 KIAA cDNA clones (supplement)
D Nakajima; N Okazaki; H Yamakawa; R Kikuno; O Ohara; T Nagase
DNA RESEARCH, 9(3), 107-115, Jun. 2002, Refereed, Not invited
Lead - Construction of expression-ready cDNA clones for KIAA genes: Manual curation of 330 KIAA cDNA clones
D Nakajima; N Okazaki; H Yamakawa; R Kikuno; O Ohara; T Nagase
DNA RESEARCH, 9(3), 99-106, Jun. 2002, Refereed, Not invited
Lead - A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling
A Pandey; N Ibarrola; Kratchmarova, I; MM Fernandez; SN Constantinescu; O Ohara; S Sawasdikosol; HF Lodish; M Mann
JOURNAL OF BIOLOGICAL CHEMISTRY, 277(21), 19131-19138, May 2002, Refereed, Not invited
Lead - Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method
O Ohara; T Nagase; G Mitsui; H Kohga; R Kikuno; S Hiraoka; Y Takahashi; S Kitajima; Y Saga; H Koseki
DNA RESEARCH, 9(2), 47-57, Apr. 2002, Refereed, Not invited
Lead - Novel alternative splicings of BPAG1 (bullous pemphigoid antigen 1) including the domain structure closely related to MACF (microtubule actin cross-linking factor)
M Okumura; H Yamakawa; O Ohara; K Owaribe
JOURNAL OF BIOLOGICAL CHEMISTRY, 277(8), 6682-6687, Feb. 2002, Refereed, Not invited
Lead - Mammalian fat3: A large protein that contains multiple cadherin and EGF-like motifs
K Mitsui; D Nakajima; O Ohara; M Nakayama
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 290(4), 1260-1266, Feb. 2002, Refereed, Not invited
Lead - HUGE: a database for human large proteins identified in the Kazusa cDNA sequencing project
R Kikuno; T Nagase; M Waki; O Ohara
NUCLEIC ACIDS RESEARCH, 30(1), 166-168, Jan. 2002, Refereed, Not invited
Lead - Intracellular cell-autonomous association of Notch and its ligands: A novel mechanism of Notch signal modification
K Sakamoto; O Ohara; M Takagi; S Takeda; K Katsube
DEVELOPMENTAL BIOLOGY, 241(2), 313-326, Jan. 2002, Refereed, Not invited
Lead - Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins
T Nagase; R Kikuno; O Ohara
DNA RESEARCH, 8(6), 319-327, Dec. 2001, Refereed, Not invited
Lead - Direct DNA sequencing of PCR products.
Dorit RL; Ohara O; Hwang CB; Kim JB; Blackshaw S
Current protocols in molecular biology, Chapter 15, Unit 15.2, Nov. 2001, Refereed, Not invited
Lead - Identification of three novel non-classical cadherin genes through comprehensive analysis of large cDNAs
D Nakajima; M Nakayama; R Kikuno; M Hirosawa; T Nagase; O Ohara
MOLECULAR BRAIN RESEARCH, 94(1-2), 85-95, Oct. 2001, Refereed, Not invited
Lead - モチーフ・ドメインリスト 細胞骨格 FERMドメイン
山川央; 小原令子; 小原収
生体の科学, 52(5), 482-483, Sep. 2001, Not invited
Lead - Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins
T Nagase; R Kikuno; O Ohara
DNA RESEARCH, 8(4), 179-187, Aug. 2001, Refereed, Not invited
Lead - cDNA amplification using one-sided (anchored) PCR.
Dorit RL; Ohara O
Current protocols in molecular biology, Chapter 15, Unit 15.6, May 2001, Refereed, Not invited
Lead - cDNA amplification using one-sided (anchored) PCR.
Dorit RL; Ohara O
Current protocols in immunology, Chapter 10, Unit 10.24, May 2001, Refereed, Not invited
Lead - Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome
T Ebisawa; M Uchiyama; N Kajimura; K Mishima; Y Kamei; M Katoh; T Watanabe; M Sekimoto; K Shibui; K Kim; Y Kudo; Y Ozeki; M Sugishita; R Toyoshima; Y Inoue; N Yamada; T Nagase; N Ozaki; O Ohara; N Ishida; M Okawa; K Takahashi; T Yamauchi
EMBO REPORTS, 2(4), 342-346, Apr. 2001, Refereed, Not invited
Lead - Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
T Nagase; M Nakayama; D Nakajima; R Kikuno; O Ohara
DNA RESEARCH, 8(2), 85-95, Apr. 2001, Refereed, Not invited
Lead - Directional cDNA library construction assisted by the in vitro recombination reaction
Osamu Ohara; Gary Temple
Nucleic acids research, 29(4), 22, Feb. 2001, Refereed, Not invited
Lead - Directional cDNA library construction assisted by the in vitro recombination reaction
Osamu Ohara; Gary Temple
NUCLEIC ACIDS RESEARCH, 29(4), E22, Feb. 2001, Refereed, Not invited
Lead - Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping
M Hirosawa; T Nagase; Y Murahashi; R Kikuno; O Ohara
DNA RESEARCH, 8(1), 1-9, Feb. 2001, Refereed, Not invited
Lead - Direct observation of DNA rotation during transcription by Escherichia coli RNA polymerase
Y Harada; O Ohara; A Takatsuki; H Itoh; N Shimamoto; K Kinosita
NATURE, 409(6816), 113-115, Jan. 2001, Refereed, Not invited
Lead - A new simplified method for preparation of a synthetic phage antibody with practically acceptable detection sensitivity on immunoblots
Manabu Nakayama; Dario Neri; Osamu Ohara
Human Antibodies, 10(2), 55-65, 2001, Refereed, Not invited
Lead - Type II brain 4.1 (4.1B/KIAA0987), a member of the protein 4.1 family, is localized to neuronal paranodes
R Ohara; H Yamakawa; M Nakayama; O Ohara
MOLECULAR BRAIN RESEARCH, 85(1-2), 41-52, Dec. 2000, Refereed, Not invited
Lead - Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
T Nagase; R Kikuno; A Hattori; Y Kondo; K Okumura; O Ohara
DNA RESEARCH, 7(6), 347-355, Dec. 2000, Refereed, Not invited
Lead - Characterization of long cDNA clones from human adult spleen
A Hattori; K Okumura; T Nagase; R Kikuno; M Hirosawa; O Ohara
DNA RESEARCH, 7(6), 357-366, Dec. 2000, Refereed, Not invited
Lead - Detection of spurious interruptions of protein-coding regions in cloned cDNA sequences by GeneMark analysis
M Hirosawa; K Ishikawa; T Nagase; O Ohara
GENOME RESEARCH, 10(9), 1333-1341, Sep. 2000, Refereed, Not invited
Lead - The yeast exchange assay, a new complementary method to screen for Db1-like protein specificity: identification of a novel RhoA exchange factor
M De Toledo; K Colombo; T Nagase; O Ohara; P Fort; A Blangy
FEBS LETTERS, 480(2-3), 287-292, Sep. 2000, Refereed, Not invited
Lead - What does Genome Analysys Offer Biophysics?
OHARA Osamu
Butsuri, 55(8), 587-593, Aug. 2000
Lead - Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
T Nagase; R Kikuno; M Nakayama; M Hirosawa; O Ohara
DNA RESEARCH, 7(4), 273-281, Aug. 2000, Refereed, Not invited
Lead - Comparison of mRNA and protein levels of four members of the protein 4.1 family: The type II brain 4.1/4.1B/KIAA0987 is the most predominant member of the protein 4.1 family in rat brain
H Yamakawa; O Ohara
GENE, 248(1-2), 137-145, May 2000, Refereed, Not invited
Lead - Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
T Nagase; R Kikuno; K Ishikawa; M Hirosawa; O Ohara
DNA RESEARCH, 7(2), 143-150, Apr. 2000, Refereed, Not invited
Lead - Prediction of the codling sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro
T Nagase; R Kikuno; KI Ishikawa; M Hirosawa; O Ohara
DNA RESEARCH, 7(1), 65-73, Feb. 2000, Refereed, Not invited
Lead - HUGE: a database for human large proteins identified in the Kazusa cDNA sequencing project
R Kikuno; T Nagase; M Suyama; M Waki; M Hirosawa; O Ohara
NUCLEIC ACIDS RESEARCH, 28(1), 331-332, Jan. 2000, Refereed, Not invited
Lead - Cellular and subcellular localization of a newly identified member of the protein 4.1 family, brain 4.1, in the cerebellum of adult and postnatally developing rats
R Ohara; H Yamakawa; M Nakayama; S Yuasa; O Ohara
DEVELOPMENTAL BRAIN RESEARCH, 117(2), 127-138, Nov. 1999, Refereed, Not invited
Lead - Cyano2Dbase updated: Linkage of 234 protein spots to corresponding genes through N-terminal microsequencing
T Sazuka; M Yamaguchi; O Ohara
ELECTROPHORESIS, 20(11), 2160-2171, Aug. 1999, Refereed, Not invited
Lead - Molecular characterization of a new member of the protein 4.1 family (brain 4.1) in rat brain
H Yamakawa; R Ohara; D Nakajima; M Nakayama; O Ohara
MOLECULAR BRAIN RESEARCH, 70(2), 197-209, Jul. 1999, Refereed, Not invited
Lead - Analysis of brain proteins in Alzheimer's disease using high-resolution two-dimensional gel electrophoresis
T Tsuji; S Shimohama; S Kamiya; T Sazuka; O Ohara
JOURNAL OF THE NEUROLOGICAL SCIENCES, 166(2), 100-106, Jul. 1999, Refereed, Not invited
Lead - HUGE: a database for human large proteins identified by Kazusa cDNA sequencing project
M Suyama; T Nagase; O Ohara
NUCLEIC ACIDS RESEARCH, 27(1), 338-339, Jan. 1999, Refereed, Not invited
Lead - Erratum: Molecular characterization of a new member of the protein 4.1 family (brain 4.1) in rat brain (Molecular Brain Research 70 (1999) (197-209) PII: S0169328X99001394)
H. Yamakawa; R. Ohara; D. Nakajima; M. Nakayama; O. Ohara
Molecular Brain Research, 74(1-2), 247, 1999, Not invited
Lead - Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
Takahiro Nagase; Ken-Ichi Ishikawa; Mikita Suyama; Reiko Kikuno; Makoto Hirosawa; Nobuyuki Miyajima; Ayako Tanaka; Hirokazu Kotani; Nobuo Nomura; Osamu Ohara
DNA Research, 6(1), 63-70, 1999, Refereed, Not invited
Lead - Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
Reiko Kikuno; Takahiro Nagase; Ken-Ichi Ishikawa; Makoto Hirosawa; Nobuyuki Miyajima; Ayako Tanaka; Hirokazu Kotani; Nobuo Nomura; Osamu Ohara
DNA Research, 6(3), 197-205, 1999, Refereed, Not invited
Lead - Characterization of cDNA clones selected by the genemark analysis from size-fractionated cDNA libraries from human brain
Makoto Hirosawa; Takahiro Nagase; Ken-Ichi Ishikawa; Reiko Kikuno; Nobuo Nomura; Osamu Ohara
DNA Research, 6(5), 329-336, 1999, Refereed, Not invited
Lead - Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
Takahiro Nagase; Ken-Ichi Ishikawa; Reiko Kikuno; Makoto Hirosawa; Nobuo Nomura; Osamu Ohara
DNA Research, 6(5), 337-345, 1999, Refereed, Not invited
Lead - Multitissue circadian expression of rat period homolog (rPer2) mRNA is governed by the mammalian circadian clock, the suprachiasmatic nucleus in the brain
K Sakamoto; T Nagase; H Fukui; K Horikawa; T Okada; H Tanaka; K Sato; Y Miyake; O Ohara; K Kako; N Ishida
JOURNAL OF BIOLOGICAL CHEMISTRY, 273(42), 27039-27042, Oct. 1998, Refereed, Not invited
Lead - Proteome analysis of cyanobacterium : Synechocystis sp. strain PCC6803
SAZUKA Takashi; OHARA Osamu
Seibutsu Butsuri, 38(5), 214-216, Sep. 1998
Lead - Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening
M Nakayama; D Nakajima; T Nagase; N Nomura; N Seki; O Ohara
GENOMICS, 51(1), 27-34, Jul. 1998, Refereed, Not invited
Lead - Characterization of a new beta-spectrin gene which is predominantly expressed in brain
O Ohara; R Ohara; H Yamakawa; D Nakajima; M Nakayama
MOLECULAR BRAIN RESEARCH, 57(2), 181-192, Jun. 1998, Refereed, Not invited
Lead - The origin and minimization of band compression atrifacts on DNA sequencing.
山川央; 小原収
生物物理, 38(1), 24-26, Feb. 1998, Not invited
Lead - Multitissue circadian expression of the rat period homologue gene is governed by a mammalian circadian clock pacemaker, the suprachiasmatic nucleus
Sakamoto;K; Nagase;T; Fukui;H; Horikawa;K; Okada;T; Tanaka;H; Sato;K; Miyake;Y; Ohara;O; Kako;K; and, Ishida;N; 加香, 孝一郎
Journal Biological Chemistry, 273, 27039-27042, Jan. 1998, Refereed, Not invited
Lead - Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB basic leucine zipper transcription factor and its mapping to chromosome 21q22.1
M Ohira; N Seki; T Nagase; K Ishikawa; N Nomura; O Ohara
GENOMICS, 47(2), 300-306, Jan. 1998, Refereed, Not invited
Lead - Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro
Takahiro Nagase; Ken-Ichi Ishikawa; Nobuyuki Miyajima; Ayako Tanaka; Hirokazu Kotani; Nobuo Nomura; Osamu Ohara
DNA Research, 5(1), 31-39, 1998, Refereed, Not invited
Lead - Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro
Ken-Ichi Ishikawa; Takahiro Nagase; Mikita Suyama; Nobuyuki Miyajima; Ayako Tanaka; Hirokazu Kotani; Nobuo Nomura; Osamu Ohara
DNA Research, 5(3), 169-176, 1998, Refereed, Not invited
Lead - Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
Takahiro Nagase; Ken-Ichi Ishikawa; Mikita Suyama; Reiko Kikuno; Nobuyuki Miyajima; Ayako Tanaka; Hirokazu Kotani; Nobuo Nomura; Osamu Ohara
DNA Research, 5(5), 277-286, 1998, Refereed, Not invited
Lead - Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
Takahiro Nagase; Ken-Ichi Ishikawa; Mikita Suyama; Reiko Kikuno; Makoto Hirosawa; Nobuyuki Miyajima; Ayako Tanaka; Hirokazu Kotani; Nobuo Nomura; Osamu Ohara
DNA Research, 5(6), 355-364, 1998, Refereed, Not invited
Lead - [A new direction of comprehensive analysis of human cDNAs: complete sequencing of relatively long human cDNA clones which encode large proteins]
Ohara O; Nagase T; Nomura N
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 42(17 Suppl), 2851-2857, Dec. 1997, Refereed, Not invited
Lead - Towards a proteome project of cyanobacterium Synechocystis sp. strain PCC6803: Linking 130 protein spots with their respective genes
T Sazuka; O Ohara
ELECTROPHORESIS, 18(8), 1252-1258, Aug. 1997, Refereed, Not invited
Lead - Sequence-dependent separation of DNA fragments by capillary electrophoresis in the presence of SYBR(R) Green I
H Takai; H Yamakawa; O Ohara; J SakaguchiInoue
BIOTECHNIQUES, 23(1), 58-&, Jul. 1997, Refereed, Not invited
Lead - Automated fluorescent DNA sequencing by a simplified solid-phase chemical sequencing method
R Ohara; A Tanaka; O Ohara
BIOTECHNIQUES, 22(4), 653-656, Apr. 1997, Refereed, Not invited
Lead - Single molecular assay of individual ATP turnover by a myosin-GFP fusion protein expressed in vitro
AH Iwane; T Funatsu; Y Harada; M Tokunaga; O Ohara; S Morimoto; T Yanagida
FEBS LETTERS, 407(2), 235-238, Apr. 1997, Refereed, Not invited
Lead - A DNA cycle sequencing reaction that minimizes compressions on automated fluorescent sequencers
H Yamakawa; O Ohara
NUCLEIC ACIDS RESEARCH, 25(6), 1311-1312, Mar. 1997, Refereed, Not invited
Lead - Gene identification in 1.6-Mb region of the down syndrome region on chromosome 21
M Ohira; N Seki; T Nagase; E Suzuki; N Nomura; O Ohara; M Hattori; Y Sakaki; T Eki; Y Murakami; T Saito; H Ichikawa; M Ohki
GENOME RESEARCH, 7(1), 47-58, Jan. 1997, Refereed, Not invited
Lead - Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21.
Ohira M; Seki N; Nagase T; Suzuki E; Nomura N; Ohara O; Hattori M; Sakaki Y; Eki T; Murakami Y; Saito T; Ichikawa H; Ohki M
Genome research, 7(1), 47-58, Jan. 1997, Refereed, Not invited
Lead - Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins
Osamu Ohara; Takahiro Nagase; Ken-Ichi Ishikawa; Daisuke Nakajima; Miki Ohira; Naohiko Seki; Nobuo Nomura
DNA Research, 4(1), 53-59, 1997, Refereed, Not invited
Lead - Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro
Takahiro Nagase; Ken-Ichi Ishikawa; Daisuke Nakajima; Miki Ohira; Naohiko Seki; Nobuyuki Miyajima; Ayako Tanaka; Hirokazu Kotani; Nobuo Nomura; Osamu Ohara
DNA Research, 4(2), 141-150, 1997, Refereed, Not invited
Lead - Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro
Ken-Ichi Ishikawa; Takahiro Nagase; Daisuke Nakajima; Naohiko Seki; Miki Ohira; Nobuyuki Miyajima; Ayako Tanaka; Hirokazu Kotani; Nobuo Nomura; Osamu Ohara
DNA Research, 4(5), 307-313, 1997, Refereed, Not invited
Lead - Characterization of cDNA clones in size-fractionated cDNA libraries from human brain
Naohiko Seki; Miki Ohira; Takahiro Nagase; Ken-Ichi Ishikawa; Nobuyuki Miyajima; Daisuke Nakajima; Nobuo Nomura; Osamu Ohara
DNA Research, 4(5), 345-349, 1997, Refereed, Not invited
Lead - Sequence-dependent DNA separation by anion-exchange high-performance liquid chromatography
H Yamakawa; KI Higashino; O Ohara
ANALYTICAL BIOCHEMISTRY, 240(2), 242-250, Sep. 1996, Refereed, Not invited
Lead - Sequence features surrounding the translation initiation sites assigned on the genome sequence of Synechocystis sp. strain PCC6803 by amino-terminal protein sequencing.
Sazuka T; Ohara O
DNA research : an international journal for rapid publication of reports on genes and genomes, 3(4), 225-232, Aug. 1996, Refereed, Not invited
Lead - Discovery of the phospholipase A(2) receptor
K Higashino; H Arita; O Ohara
DRUG NEWS & PERSPECTIVES, 9(2), 87-92, Mar. 1996, Refereed, Not invited
Lead - An improved cosmid vector for the nested deletion method using the bacteriophage T3 DNA packaging system
Yutaka Kawarabayasi; Daisuke Nakajima; Hisao Fujisawa; Osamu Ohara
DNA Research, 3(1), 37-42, 1996, Refereed, Not invited
Lead - Identification of sequence motifs causing band compressions on human cDNA sequencing
Hisashi Yamakawa; Daisuke Nakajima; Osamu Ohara
DNA Research, 3(2), 81-86, 1996, Refereed, Not invited
Lead - Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain
Takahiro Nagase; Naohiko Seki; Ken-Ichi Ishikawa; Miki Ohira; Yutaka Kawarabayasi; Osamu Ohara; Ayako Tanaka; Hirokazu Kotani; Nobuyuki Miyajima; Nobuo Nomura
DNA Research, 3(5), 321-329, 1996, Refereed, Not invited
Lead - EFFECTS OF BRAIN-DERIVED NEUROTROPHIC FACTOR ON 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-INDUCED PARKINSONISM IN MONKEYS
T TSUKAHARA; M TAKEDA; S SHIMOHAMA; O OHARA; N HASHIMOTO
NEUROSURGERY, 37(4), 733-739, Oct. 1995, Refereed, Not invited
Lead - A NOVEL RING-H2 MOTIF PROTEIN DOWN-REGULATED BY AXOTOMY - ITS CHARACTERISTIC LOCALIZATION AT THE POSTSYNAPTIC DENSITY OF AXOSOMATIC SYNAPSE
M NAKAYAMA; T MIYAKE; Y GAHARA; O OHARA; T KITAMURA
JOURNAL OF NEUROSCIENCE, 15(7), 5238-5248, Jul. 1995, Refereed, Not invited
Lead - VASCULAR SMOOTH-MUSCLE CELL-DERIVED, GLA-CONTAINING GROWTH-POTENTIATING FACTOR FOR CA2+-MOBILIZING GROWTH-FACTORS
T NAKANO; K HIGASHINO; N KIKUCHI; J KISHINO; K NOMURA; H FUJITA; O OHARA; H ARITA
JOURNAL OF BIOLOGICAL CHEMISTRY, 270(11), 5702-5705, Mar. 1995, Refereed, Not invited
Lead - PANCREATIC-TYPE PHOSPHOLIPASE A(2), ACTIVATES PROSTAGLANDIN E(2) PRODUCTION IN RAT MESANGIAL CELLS BY RECEPTOR-BINDING REACTION
J KISHINO; K KAWAMOTO; J ISHIZAKI; HM VERHEIJ; O OHARA; H ARITA
JOURNAL OF BIOCHEMISTRY, 117(2), 420-424, Feb. 1995, Refereed, Not invited
Lead - STRUCTURAL CHARACTERIZATION OF PANCREATIC GROUP-I PHOSPHOLIPASE A(2) RECEPTOR
J ISHIZAKI; KI HIGASHINO; O OHARA; H ARITA
PROSTAGLANDINS AND RELATED COMPOUNDS, 23, 85-87, 1995, Refereed, Not invited
Lead - STRUCTURE AND FUNCTION OF PHOSPHOLIPASE A(2) RECEPTOR
O OHARA; J ISHIZAKI; H ARITA
PROGRESS IN LIPID RESEARCH, 34(2), 117-138, 1995, Refereed, Not invited
Lead - Structural characterization of pancreatic group I phospholipase A2 receptor.
Ishizaki J; Higashino K; Ohara O; Arita H
Advances in prostaglandin, thromboxane, and leukotriene research, 23, 85-87, 1995, Refereed, Not invited
Lead - A new solid-phase chemical DNA sequencing method which uses streptavidin-coated magnetic beads
Reiko Ohara; Osamu Ohara
DNA Research, 2(3), 123-128, 1995, Refereed, Not invited
Lead - [Structure and function of pancreatic group I phospholipase A2 receptor].
Ohara O; Arita H
Seikagaku. The Journal of Japanese Biochemical Society, 66(11), 1371-1386, Nov. 1994, Refereed, Not invited
Lead - STRUCTURAL COMPARISON OF PHOSPHOLIPASE-A(2)-BINDING REGIONS IN PHOSPHOLIPASE-A(2) RECEPTORS FROM VARIOUS MAMMALS
K HIGASHINO; J ISHIZAKI; J KISHINO; O OHARA; H ARITA
EUROPEAN JOURNAL OF BIOCHEMISTRY, 225(1), 375-382, Oct. 1994, Refereed, Not invited
Lead - The Role of Brain-derived Neurotrophic Factor in Transient Forebrain Ischemia in the Rat Brain.
Tsukahara T; Yonekawa Y; Tanaka K; Ohara O; Watanabe S; Kimura T; Nishijima T; Taniguchi T
Feb. 1994
Lead - DISTINCTIVE 4 PROMOTERS COLLECTIVELY DIRECT EXPRESSION OF BRAIN-DERIVED NEUROTROPHIC FACTOR GENE
M NAKAYAMA; Y GAHARA; T KITAMURA; O OHARA
MOLECULAR BRAIN RESEARCH, 21(3-4), 206-218, Feb. 1994, Refereed, Not invited
Lead - PANCREATIC-TYPE PHOSPHOLIPASE A(2) INDUCES GROUP-II PHOSPHOLIPASE A(2) EXPRESSION AND PROSTAGLANDIN BIOSYNTHESIS IN RAT MESANGIAL CELLS
J KISHINO; O OHARA; K NOMURA; RM KRAMER; H ARITA
JOURNAL OF BIOLOGICAL CHEMISTRY, 269(7), 5092-5098, Feb. 1994, Refereed, Not invited
Lead - MOLECULAR-CLONING OF PANCREATIC GROUP-I PHOSPHOLIPASE A(2) RECEPTOR
J ISHIZAKI; K HANASAKI; K HIGASHINO; J KISHINO; N KIKUCHI; O OHARA; H ARITA
JOURNAL OF BIOLOGICAL CHEMISTRY, 269(8), 5897-5904, Feb. 1994, Refereed, Not invited
Lead - GASTROCOLIC FISTULA ORIGINATING FROM TRANSVERSE COLON-CANCER - REPORT OF A CASE AND REVIEW OF THE JAPANESE LITERATURE
Osamu Ohara
Surgery Today, 1994
Lead - A NEW ASPECT OF PLA2 FUNCTION VIA SPECIFIC RECEPTOR
H ARITA; O OHARA
LIPID MEDIATORS IN HEALTH AND DISEASE (LMHD), 51-55, 1994, Refereed, Not invited
Lead - A novel method for generating nested deletions using the in vitro bacteriophage T3 DNA packaging system
Yutaka Kawarabayasi; Ayako Tanaka; Osamu Ohara; Taku Arakawa; Masanori Oka; Hisako Kato; Miyo Morita; Hisao Fujisawa
DNA Research, 1(6), 289-296, 1994, Refereed, Not invited
Lead - The role of brain-derived neurotrophic factor in transient forebrain ischemia in the rat brain
Tetsuya Tsukahara; Yasuhiro Yonekawa; Kimito Tanaka; Osamu Ohara; Sachihiko Watanabe; Tetsuya Kimura; Tetsuji Nishijima; Takashi Taniguchi
Neurosurgery, 34(2), 323-331, 1994, Refereed, Not invited
Lead - BRAIN-DERIVED NEUROTROPHIC FACTOR PRETREATMENT EXERTS A PARTIALLY PROTECTIVE EFFECT AGAINST GLUTAMATE-INDUCED NEUROTOXICITY IN CULTURED RAT CORTICAL-NEURONS
S SHIMOHAMA; Y TAMURA; A AKAIKE; T TSUKAHARA; O OHARA; S WATANABE; J KIMURA
NEUROSCIENCE LETTERS, 164(1-2), 55-58, Dec. 1993, Refereed, Not invited
Lead - RECEPTOR-BINDING CAPABILITY OF PANCREATIC PHOSPHOLIPASE-A2 IS SEPARABLE FROM ITS ENZYMATIC-ACTIVITY
J ISHIZAKI; J KISHINO; H TERAOKA; O OHARA; H ARITA
FEBS LETTERS, 324(3), 349-352, Jun. 1993, Refereed, Not invited
Lead - NEUROFILAMENT DEFICIENCY IN QUAIL CAUSED BY NONSENSE MUTATION IN NEUROFILAMENT-L GENE
O OHARA; Y GAHARA; T MIYAKE; H TERAOKA; T KITAMURA
JOURNAL OF CELL BIOLOGY, 121(2), 387-395, Apr. 1993, Refereed, Not invited
Lead - A CASE OF INTRACYSTIC CARCINOMA OF THE BREAST - THE IMPORTANCE OF MEASURING CARCINOEMBRYONIC ANTIGEN IN ASPIRATED CYSTIC FLUID
Osamu Ohara
Breast Cancer Research and Treatment, 1993
Lead - ONE-SIDED ANCHORED POLYMERASE CHAIN-REACTION FOR AMPLIFICATION AND SEQUENCING OF COMPLEMENTARY-DNA
RL DORIT; O OHARA; W GILBERT
METHODS IN ENZYMOLOGY, 218, 36-47, 1993, Refereed, Not invited
Lead - A RAT BRAIN-DERIVED NEUROTROPHIC FACTOR-ENCODING GENE GENERATES MULTIPLE TRANSCRIPTS THROUGH ALTERNATIVE USE OF 5' EXONS AND POLYADENYLATION SITES
O OHARA; Y GAHARA; H TERAOKA; T KITAMURA
GENE, 121(2), 383-386, Nov. 1992, Refereed, Not invited
Lead - DISORGANIZATION OF MICROFILAMENTS IS ACCOMPANIED BY DOWN-REGULATION OF ALPHA-SMOOTH MUSCLE ACTIN ISOFORM MESSENGER-RNA LEVEL IN CULTURED VASCULAR SMOOTH-MUSCLE CELLS
K NOMURA; H TERAOKA; H ARITA; O OHARA
JOURNAL OF BIOCHEMISTRY, 112(1), 102-106, Jul. 1992, Refereed, Not invited
Lead - [Molecular aspects of mammalian phospholipases A2 from the standpoint of arachidonic acid release].
Ohara O; Arita H
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 37(6), 898-905, May 1992, Refereed, Not invited
Lead - CAMP NEGATIVELY REGULATES MESSENGER-RNA LEVELS OF ACTIN AND TROPOMYOSIN IN RAT CULTURED VASCULAR SMOOTH-MUSCLE CELLS
O OHARA; T NAKANO; H TERAOKA; H ARITA
JOURNAL OF BIOCHEMISTRY, 109(6), 834-839, Jun. 1991, Refereed, Not invited
Lead - ACTIVATION OF GROUP-II PHOSPHOLIPASE-A2 GENE VIA 2 DISTINCT MECHANISMS IN RAT VASCULAR SMOOTH-MUSCLE CELLS
H ARITA; T NAKANO; O OHARA; H TERAOKA
PROSTAGLANDINS AND RELATED COMPOUNDS, VOLS A AND B, 21, 277-280, 1991, Refereed, Not invited
Lead - A SIMPLE AND SENSITIVE METHOD FOR DETERMINING TRANSCRIPTION INITIATION SITE - IDENTIFICATION OF 2 TRANSCRIPTION INITIATION SITES IN RAT GROUP-II PHOSPHOLIPASE-A2 GENE
O OHARA; J ISHIZAKI; T NAKANO; H ARITA; H TERAOKA
NUCLEIC ACIDS RESEARCH, 18(23), 6997-7002, Dec. 1990, Refereed, Not invited
Lead - [Rapid cDNA sequencing method using the polymerase chain reaction]
Ohara O
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 35(14), 2319-2328, Oct. 1990, Refereed, Not invited
Lead - GLUCOCORTICOIDS SUPPRESS GROUP-II PHOSPHOLIPASE-A2 PRODUCTION BY BLOCKING MESSENGER-RNA SYNTHESIS AND POSTTRANSCRIPTIONAL EXPRESSION
T NAKANO; O OHARA; H TERAOKA; H ARITA
JOURNAL OF BIOLOGICAL CHEMISTRY, 265(21), 12745-12748, Jul. 1990, Refereed, Not invited
Lead - GROUP-II PHOSPHOLIPASE-A2 MESSENGER-RNA SYNTHESIS IS STIMULATED BY 2 DISTINCT MECHANISMS IN RAT VASCULAR SMOOTH-MUSCLE CELLS
T NAKANO; O OHARA; H TERAOKA; H ARITA
FEBS LETTERS, 261(1), 171-174, Feb. 1990, Refereed, Not invited
Lead - DIRECT GENOMIC SEQUENCING OF BACTERIAL-DNA - THE PYRUVATE KINASE-I GENE OF ESCHERICHIA-COLI
O OHARA; RL DORIT; W GILBERT
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 86(18), 6883-6887, Sep. 1989, Refereed, Not invited
Lead - ONE-SIDED POLYMERASE CHAIN-REACTION - THE AMPLIFICATION OF CDNA
O OHARA; RL DORIT; W GILBERT
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 86(15), 5673-5677, Aug. 1989, Refereed, Not invited
Lead - CDNA CLONING AND SEQUENCE DETERMINATION OF RAT MEMBRANE-ASSOCIATED PHOSPHOLIPASE-A2
J ISHIZAKI; O OHARA; E NAKAMURA; M TAMAKI; T ONO; A KANDA; N YOSHIDA; H TERAOKA; H TOJO; M OKAMOTO
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 162(3), 1030-1036, Aug. 1989, Refereed, Not invited
Lead - ANOMALOUS BEHAVIOR OF HUMAN-LEUKOCYTE INTERFERON SUBTYPES ON POLYACRYLAMIDE-GEL ELECTROPHORESIS IN THE PRESENCE OF DODECYL-SULFATE
O OHARA; H TERAOKA
FEBS LETTERS, 211(1), 78-82, Jan. 1987, Refereed, Not invited
Lead - PURIFICATION AND CHARACTERIZATION OF RECOMBINANT MURINE IMMUNE INTERFERON
K NAGATA; N KIKUCHI; O OHARA; H TERAOKA; N YOSHIDA; Y KAWADE
FEBS LETTERS, 205(2), 200-204, Sep. 1986, Refereed, Not invited
Lead - DOG AND RAT PANCREATIC PHOSPHOLIPASES-A2 - COMPLETE AMINO-ACID-SEQUENCES DEDUCED FROM COMPLEMENTARY DNAS
O OHARA; M TAMAKI; E NAKAMURA; Y TSURUTA; Y FUJII; M SHIN; H TERAOKA; M OKAMOTO
JOURNAL OF BIOCHEMISTRY, 99(3), 733-739, Mar. 1986, Refereed, Not invited
Lead - CHROMATOGRAPHIC ANALYSIS OF SUBERIMIDATE-CROSSLINKED LYSINE
O OHARA; S TAKAHASHI
JOURNAL OF LIQUID CHROMATOGRAPHY, 7(8), 1665-1672, 1984, Refereed, Not invited
Lead - CROSS-LINKING STUDY ON SKELETAL-MUSCLE ACTIN - INTERACTION OF SUBERIMIDATE-TREATED ACTIN WITH DEOXYRIBONUCLEASE-I
O OHARA; S TAKAHASHI; T OOI
JOURNAL OF BIOCHEMISTRY, 93(6), 1547-1556, 1983, Refereed, Not invited
Lead - CROSS-LINKING STUDY ON SKELETAL-MUSCLE ACTIN - PROPERTIES OF SUBERIMIDATE-TREATED ACTIN
O OHARA; S TAKAHASHI; T OOI; Y FUJIYOSHI
JOURNAL OF BIOCHEMISTRY, 91(6), 1999-2012, 1982, Refereed, Not invited
Lead - FIXATION OF SKELETAL-MUSCLE ACTIN IN F-STATE BY CHEMICAL CROSS-LINKING WITH BIS-IMIDOESTERS
O OHARA; S TAKAHASHI; T OOI; Y FUJIYOSHI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 100(3), 988-994, 1981, Refereed, Not invited
Lead - CROSS-LINKING STUDY ON TROPOMYOSIN
O OHARA; S TAKAHASHI; T OOI
JOURNAL OF BIOCHEMISTRY, 87(6), 1795-1803, 1980, Refereed, Not invited
Lead - ANALYSIS OF ADIPIMIDATE-CROSSLINKED LYSINE
O OHARA; S TAKAHASHI
ANALYTICAL BIOCHEMISTRY, 107(2), 314-317, 1980, Refereed, Not invited
Lead - STUDIES ON REGULATION OF ONE-CARBON METABOLISM - EFFECTS OF FOLATE CONCENTRATION IN GROWTH MEDIUM ON ACTIVITY OF 3 FOLATE-DEPENDENT ENZYMES IN LACTOBACILLUS CASEI
Osamu Ohara
Journal of Biological Chemistry, 1969
Lead - Two novel HSD3B2 missense mutations with diverse residual enzymatic activities for Δ5-steroids
Kei Takasawa; Makoto Ono; Atsushi Hijikata; Yohei Matsubara; Noriyuki Katsumata; Masatoshi Takagi; Tomohiro Morio; Osamu Ohara; Kenichi Kashimada; Shuki Mizutani - Identification of Differentially Expressed Proteins in the Serum for Systemic Juvenile Idiopathic Arthritis Using Next-generation Proteomics
Hironori Sato; Yuzaburo Inoue; Yusuke Kawashima; Daisuke Nakajima; Ren Nakamura; Daigo Kato; Kanako Mitsunaga; Takeshi Yamamoto; Akiko Yamaide; Minako Tomiita; Akira Hoshioka; Osamu Ohara; Naoki Shimojo - CXCR4-Expressing Anti-CD25 CAR T-Cells Effectively Eliminate Human AML Cells In Vivo
Ari Itoh-Nakadai; Yoriko Saito; Mariko Murasawa-Tomizawa; Hiroshi Kajita; Takehisa Matsumoto; Masashi Matsuda; Takashi Watanabe; Mikako Shirouzu; Osamu Ohara; Haruhiko Koseki; Leonard Shultz; Fumihiko Ishikawa - A novel truncating mutation in FLNA causes periventricular nodular heterotopia, Ehlers-Danlos-like collagenopathy and macrothrombocytopenia
Daisuke Ieda; Ikumi Hori; Yuji Nakamura; Hironori Ohshita; Yutaka Negishi; Tsutomu Shinohara; Ayako Hattori; Takenori Kato; Sachiko Inukai; Katsumasa Kitamura; Tomoki Kawai; Osamu Ohara; Shinji Kunishima; Shinji Saitoh - Newborn screening for carnitine palmitoyltransferase II deficiency using (C16+C18:1)/C2: Evaluation of additional indices for adequate sensitivity and lower false-positivity
Go Tajima; Keiichi Hara; Miyuki Tsumura; Reiko Kagawa; Satoshi Okada; Nobuo Sakura; Shinsuke Maruyama; Atsuko Noguchi; Tomonari Awaya; Mika Ishige; Nobuyuki Ishige; Ikuma Musha; Sayaka Ajihara; Akira Ohtake; Etsuo Naito; Yusuke Hamada; Tomotaka Kono; Tomoko Asada; Hideo Sasai; Toshiyuki Fukao; Ryoji Fujiki; Osamu Ohara; Ryosuke Bo; Kenji Yamada; Hironori Kobayashi; Yuki Hasegawa; Seiji Yamaguchi; Masaki Takayanagi; Ikue Hata; Yosuke Shigematsu; Masao Kobayashi - Immunodeficiency in Two Female Patients with Incontinentia Pigmenti with Heterozygous NEMO Mutation Diagnosed by LPS Unresponsiveness
Hidenori Ohnishi; Yuka Kishimoto; Tomohide Taguchi; Norio Kawamoto; Mina Nakama; Tomoki Kawai; Manabu Nakayama; Osamu Ohara; Kenji Orii; Toshiyuki Fukao - Alanine-scanning mutagenesis of human signal transducer and activator of transcription 1 to estimate loss- or gain-of-function variants
Reiko Kagawa; Ryoji Fujiki; Miyuki Tsumura; Sonoko Sakata; Shiho Nishimura; Yuval Itan; Xiao-Fei Kong; Zenichiro Kato; Hidenori Ohnishi; Osamu Hirata; Satoshi Saito; Maiko Ikeda; Jamila El Baghdadi; Aziz Bousfiha; Kaori Fujiwara; Matias Oleastro; Judith Yancoski; Laura Perez; Silvia Danielian; Fatima Ailal; Hidetoshi Takada; Toshiro Hara; Anne Puel; Stephanie Boisson-Dupuis; Jacinta Bustamante; Jean-Laurent Casanova; Osamu Ohara; Satoshi Okada; Masao Kobayashi - Infection Profile in Chronic Granulomatous Disease: a 23-Year Experience from a Tertiary Care Center in North India
Amit Rawat; Pandiarajan Vignesh; Avinash Sharma; Jitendra K. Shandilya; Madhubala Sharma; Deepti Suri; Anju Gupta; Vikas Gautam; Pallab Ray; Shivaprakash M. Rudramurthy; Arunaloke Chakrabarti; Kohsuke Imai; Shigeaki Nonoyama; Osamu Ohara; Yu L. Lau; Surjit Singh - A deletion in the intergenic region upstream of Ednrb causes head spot in the rat strain KFRS4/Kyo
Minako Yoshihara; Tetsuya Sato; Daisuke Saito; Osamu Ohara; Takashi Kuramoto; Mikita Suyama - Identification of a High-Frequency Somatic NLRC4 Mutation as a Cause of Autoinflammation by Pluripotent Cell-Based Phenotype Dissection
Yuri Kawasaki; Hirotsugu Oda; Jun Ito; Akira Niwa; Takayuki Tanaka; Atsushi Hijikata; Ryosuke Seki; Ayako Nagahashi; Mitsujiro Osawa; Isao Asaka; Akira Watanabe; Shigeo Nishimata; Tsuyoshi Shirai; Hisashi Kawashima; Osamu Ohara; Tatsutoshi Nakahata; Ryuta Nishikomori; Toshio Heike; Megumu K. Saito - A CD57(+) CTL Degranulation Assay Effectively Identifies Familial Hemophagocytic Lymphohistiocytosis Type 3 Patients
Masayuki Hori; Takahiro Yasumi; Saeko Shimodera; Hirofumi Shibata; Eitaro Hiejima; Hirotsugu Oda; Kazushi Izawa; Tomoki Kawai; Masataka Ishimura; Naoko Nakano; Ryutaro Shirakawa; Ryuta Nishikomori; Hidetoshi Takada; Satoshi Morita; Hisanori Horiuchi; Osamu Ohara; Eiichi Ishii; Toshio Heike - Phosphatase and tensin homolog (PTEN) mutation can cause activated phosphatidylinositol 3-kinase delta syndrome-like immunodeficiency
Yuki Tsujita; Kanako Mitsui-Sekinaka; Kohsuke Imai; Tzu-Wen Yeh; Noriko Mitsuiki; Takaki Asano; Hidenori Ohnishi; Zenichiro Kato; Yujin Sekinaka; Kiyotaka Zaha; Tamaki Kato; Tsubasa Okano; Takehiro Takashima; Kaoru Kobayashi; Mitsuaki Kimura; Tomoaki Kunitsu; Yoshihiro Maruo; Hirokazu Kanegane; Masatoshi Takagi; Kenichi Yoshida; Yusuke Okuno; Hideki Muramatsu; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Seiji Kojima; Seishi Ogawa; Osamu Ohara; Satoshi Okada; Masao Kobayashi; Tomohiro Morio; Shigeaki Nonoyama - Clinical and Genetic Features of Patients With TNFRSF1A Variants in Japan: Findings of a Nationwide Survey
Naoyasu Ueda; Hiroaki Ida; Masakazu Washio; Hisaaki Miyahara; Shoji Tokunaga; Fumiko Tanaka; Hiroki Takahashi; Koichi Kusuhara; Koichiro Ohmura; Manabu Nakayama; Osamu Ohara; Ryuta Nishikomori; Seiji Minota; Shuji Takei; Takao Fujii; Yoshiaki Ishigatsubo; Hiroshi Tsukamoto; Tomoko Tahira; Takahiko Horiuchi - Novel compound heterozygous mutations in a Japanese girl with Janus kinase 3 deficiency
Takeshi Sato; Tsubasa Okano; Mari Tanaka-Kubota; Shunsuke Kimura; Satoshi Miyamoto; Shintaro Ono; Motoi Yamashita; Noriko Mitsuiki; Masatoshi Takagi; Kohsuke Imai; Michiko Kajiwara; Takasuke Ebato; Shohei Ogata; Hirotsugu Oda; Osamu Ohara; Hirokazu Kanegane; Tomohiro Morio - X-linked agammaglobulinemia Twenty years of single-center experience from North West India
Surjit Singh; Amit Rawat; Deepti Suri; Anju Gupta; Ravinder Garg; Biman Saikia; Ranjana Walker Minz; Shobha Sehgal; Koon-Wing Chan; Yu Lung Lau; Chikako Kamae; Kenichi Honma; Noriko Nakagawa; Kohsuke Imai; Shigeaki Nonoyama; Koichi Oshima; Noriko Mitsuiki; Osamu Ohara - Design and application of a target capture sequencing of exons and conserved non-coding sequences for the rat
Minako Yoshihara; Daisuke Saito; Tetsuya Sato; Osamu Ohara; Takashi Kuramoto; Mikita Suyama - Identification of Individual Cancer-Specific Somatic Mutations for Neoantigen-Based Immunotherapy of Lung Cancer
Takahiro Karasaki; Kazuhiro Nagayama; Mitsuaki Kawashima; Noriko Hiyama; Tomonori Murayama; Hideki Kuwano; Jun-ichi Nitadori; Masaki Anraku; Masaaki Sato; Manami Miyai; Akihiro Hosoi; Hirokazu Matsushita; Shingo Kikugawa; Ryo Matoba; Osamu Ohara; Kazuhiro Kakimi; Jun Nakajima - Invasive Bacterial Infection in Patients with Interleukin-1 Receptor-associated Kinase 4 Deficiency Case Report
Hidetoshi Takada; Masataka Ishimura; Tomohito Takimoto; Toaki Kohagura; Hideto Yoshikawa; Masue Imaizumi; Koichi Shichijyou; Yoko Shimabukuro; Tomoo Kise; Nobuyuki Hyakuna; Osamu Ohara; Shigeaki Nonoyama; Toshiro Hara - Role of Bcl-3 in the Development of Follicular Helper T Cells and in the Pathogenesis of Rheumatoid Arthritis
Kazuyuki Meguro; Kotaro Suzuki; Junichi Hosokawa; Yoshie Sanayama; Shigeru Tanaka; Shunsuke Furuta; Kei Ikeda; Hiroaki Takatori; Akira Suto; Akemi Sakamoto; Osamu Ohara; Hiroshi Nakajima - Mosaicism of an ELANE Mutation in an Asymptomatic Mother in a Familial Case of Cyclic Neutropenia
Osamu Hirata; Satoshi Okada; Miyuki Tsumura; Shuhei Karakawa; Itaru Matsumura; Yujiro Kimura; Toshiro Maihara; Shin'ichiro Yasunaga; Yoshihiro Takihara; Osamu Ohara; Masao Kobayashi - RAG1 Deficiency May Present Clinically as Selective IgA Deficiency
Osamu Ohara - RAG1 Deficiency May Present Clinically as Selective IgA Deficiency
Tamaki Kato; Elena Crestani; Chikako Kamae; Kenichi Honma; Tomoko Yokosuka; Takeshi Ikegawa; Naonori Nishida; Hirokazu Kanegane; Taizo Wada; Akihiro Yachie; Osamu Ohara; Tomohiro Morio; Luigi D. Notarangelo; Kohsuke Imai; Shigeaki Nonoyama - Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes
Kenji Nakagawa; Eva Gonzalez-Roca; Alejandro Souto; Toshinao Kawai; Hiroaki Umebayashi; Josep Maria Campistol; Jeronima Canellas; Syuji Takei; Norimoto Kobayashi; Jose Luis Callejas-Rubio; Norberto Ortego-Centeno; Estibaliz Ruiz-Ortiz; Fina Rius; Jordi Anton; Estibaliz Iglesias; Santiago Jimenez-Trevino; Carmen Vargas; Julian Fernandez-Martin; Inmaculada Calvo; Jose Hernandez-Rodriguez; Maria Mendez; Maria Teresa Dordal; Maria Basagana; Segundo Bujan; Masato Yashiro; Tetsuo Kubota; Ryuji Koike; Naoko Akuta; Kumiko Shimoyama; Naomi Iwata; Megumu K. Saito; Osamu Ohara; Naotomo Kambe; Takahiro Yasumi; Kazushi Izawa; Tomoki Kawai; Toshio Heike; Jordi Yaguee; Ryuta Nishikomori; Juan I. Arostegui - Enhanced Chondrogenesis of Induced Pluripotent Stem Cells From Patients With Neonatal-Onset Multisystem Inflammatory Disease Occurs via the Caspase 1-Independent cAMP/Protein Kinase A/CREB Pathway
Koji Yokoyama; Makoto Ikeya; Katsutsugu Umeda; Hirotsugu Oda; Seishiro Nodomi; Akira Nasu; Yoshihisa Matsumoto; Kazushi Izawa; Kazuhiko Horigome; Toshimasa Kusaka; Takayuki Tanaka; Megumu K. Saito; Takahiro Yasumi; Ryuta Nishikomori; Osamu Ohara; Naoki Nakayama; Tatsutoshi Nakahata; Toshio Heike; Junya Toguchida - Hyper-IgE syndrome with a novel STAT3 mutation-a single center study from India
Biman Saikia; Deepti Suri; Shubham Goel; Amit Rawat; Ranjana W. Minz; Anju Gupta; Sudha Sharma; Osamu Ohara; Kohsuke Imai; Shigeaki Nonoyama; Shobha Sehgal; Surjit Singh - A Complement Factor B Mutation in a Large Kindred with Atypical Hemolytic Uremic Syndrome
Michinori Funato; Osamu Uemura; Katsumi Ushijima; Hidenori Ohnishi; Kenji Orii; Zenichiro Kato; Satoshi Yamakawa; Takuhito Nagai; Osamu Ohara; Hideo Kaneko; Naomi Kondo - Clinical and Genetic Characterization of Japanese Sporadic Cases of Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis Syndrome from a Single Medical Center in Japan
Kazuo Kubota; Hidenori Ohnishi; Takahide Teramoto; Norio Kawamoto; Kimiko Kasahara; Osamu Ohara; Naomi Kondo - Two novel HSD3B2 missense mutations with diverse residual enzymatic activities for Delta 5-steroids
Kei Takasawa; Makoto Ono; Atsushi Hijikata; Yohei Matsubara; Noriyuki Katsumata; Masatoshi Takagi; Tomohiro Morio; Osamu Ohara; Kenichi Kashimada; Shuki Mizutani - Prediction of Therapeutic Responses to Tocilizumab in Patients With Rheumatoid Arthritis Biomarkers Identified by Analysis of Gene Expression in Peripheral Blood Mononuclear Cells Using Genome-Wide DNA Microarray
Yoshie Sanayama; Kei Ikeda; Yukari Saito; Shin-ichiro Kagami; Mieko Yamagata; Shunsuke Furuta; Daisuke Kashiwakuma; Itsuo Iwamoto; Takeshi Umibe; Yasushi Nawata; Ryutaro Matsumura; Takao Sugiyama; Makoto Sueishi; Masaki Hiraguri; Ken Nonaka; Osamu Ohara; Hiroshi Nakajima - Clinical and mutational features of Vietnamese children with X-linked agammaglobulinemia
Quang Van Vu; Taizo Wada; Huong Thi Minh Le; Hai Thanh Le; Anh Thi Van Nguyen; Ohara Osamu; Akihiro Yachie; Sang Ngoc Nguyen - AT-Rich-Interactive Domain-Containing Protein 5A Functions as a Negative Regulator of Retinoic Acid Receptor-Related Orphan Nuclear Receptor gamma t-Induced Th17 Cell Differentiation
Yukari Saito; Shin-ichiro Kagami; Yoshie Sanayama; Kei Ikeda; Akira Suto; Daisuke Kashiwakuma; Shunsuke Furuta; Itsuo Iwamoto; Ken Nonaka; Osamu Ohara; Hiroshi Nakajima - Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation
Hiroshi Kitamura; Shunsuke Kimura; Yoshinori Shimamoto; Jun Okabe; Masatoshi Ito; Tomomi Miyamoto; Yoshinori Naoe; Chisato Kikuguchi; Bob Meek; Chitoku Toda; Shiki Okamoto; Katsushi Kanehira; Koji Hase; Hiroshi Watarai; Mayumi Ishizuka; Assam El-Osta; Osamu Ohara; Ichiro Miyoshi - A novel Wiskott-Aldrich syndrome protein mutation in an infant with thrombotic thrombocytopenic purpura
Yukako Kawasaki; Hidemi Toyoda; Shoichiro Otsuki; Tadashi Iwasa; Shotaro Iwamoto; Eiichi Azuma; Naomi Itoh-Habe; Hideo Wada; Yoshihiro Fujimura; Tomohiro Morio; Kohsuke Imai; Noriko Mitsuiki; Osamu Ohara; Yoshihiro Komada - Autosomal-dominant chronic mucocutaneous candidiasis with stat1-mutation can be complicated with chronic active hepatitis and hypothyroidism
Tomohiro Hori; Hidenori Ohnishi; Takahide Teramoto; Kohji Tsubouchi; Takafumi Naiki; Yoshinobu Hirose; Osamu Ohara; Mariko Seishima; Hideo Kaneko; Toshiyuki Fukao; Naomi Kondo - Autosomal-dominant chronic mucocutaneous candidiasis with stat1-mutation can be complicated with chronic active hepatitis and hypothyroidism
Tomohiro Hori; Hidenori Ohnishi; Takahide Teramoto; Kohji Tsubouchi; Takafumi Naiki; Yoshinobu Hirose; Osamu Ohara; Mariko Seishima; Hideo Kaneko; Toshiyuki Fukao; Naomi Kondo - Clinical profile and genetic basis of Wiskott-Aldrich syndrome at Chandigarh, north India
Deepti Suri; Surjit Singh; Amit Rawat; Anju Gupta; Chikako Kamae; Kenichi Honma; Noriko Nakagawa; Kohsuke Imai; Shigeaki Nonoyama; Koichi Oshima; Noriko Mitsuiki; Osamu Ohara; Chrystele Bilhou-Nabera; Alexis Proust; Jasmina Ahluwalia; Sunil Dogra; Biman Saikia; Ranjana Walker Minz; Shobha Sehgal - High Incidence of NLRP3 Somatic Mosaicism in Patients With Chronic Infantile Neurologic, Cutaneous, Articular Syndrome Results of an International Multicenter Collaborative Study
Naoko Tanaka; Kazushi Izawa; Megumu K. Saito; Mio Sakuma; Koichi Oshima; Osamu Ohara; Ryuta Nishikomori; Takeshi Morimoto; Naotomo Kambe; Raphaela Goldbach-Mansky; Ivona Aksentijevich; Genevieve de Saint Basile; Benedicte Neven; Marielle van Gijn; Joost Frenkel; Juan I. Arostegui; Jordi Yaguee; Rosa Merino; Mercedes Ibanez; Alessandra Pontillo; Hidetoshi Takada; Tomoyuki Imagawa; Tomoki Kawai; Takahiro Yasumi; Tatsutoshi Nakahata; Toshio Heike - Clinical and Host Genetic Characteristics of Mendelian Susceptibility to Mycobacterial Diseases in Japan
Takayuki Hoshina; Hidetoshi Takada; Yuka Sasaki-Mihara; Koichi Kusuhara; Koichi Ohshima; Satoshi Okada; Masao Kobayashi; Osamu Ohara; Toshiro Hara - Hemophagocytosis after bone marrow transplantation for JAK3-deficient severe combined immunodeficiency
Yoshiko Hashii; Hisao Yoshida; Sato Kuroda; Shigenori Kusuki; Emiko Sato; Sadao Tokimasa; Hideaki Ohta; Yasutaka Matsubara; Seiji Kinoshita; Noriko Nakagawa; Kohsuke Imai; Shigeaki Nonoyama; Koichi Oshima; Osamu Ohara; Keiichi Ozono - A set of genes associated with the interferon-γ response of lung cancer patients undergoing α-galactosylceramide-pulsed dendritic cell therapy
Kohsuke Okita; Shinichiro Motohashi; Ryo Shinnakasu; Kaoru Nagato; Kazuki Yamasaki; Yasunori Sato; Hiroshi Kitamura; Atsushi Hijikata; Masakatsu Yamashita; Kanako Shimizu; Shin-ichiro Fujii; Osamu Ohara; Masaru Taniguchi; Isao Sakaida; Toshinori Nakayama - The NMR solution structures of the five constituent cold-shock domains (CSD) of the human UNR (upstream of N-ras) protein
Alexander K. Goroncy; Seizo Koshiba; Naoya Tochio; Tadashi Tomizawa; Makato Inoue; Satoru Watanabe; Takushi Harada; Akiko Tanaka; Osamu Ohara; Takanori Kigawa; Shigeyuki Yokoyama - Ataxia-Telangiectasia in a Patient Presenting With Hyper-immunoglobulin M Syndrome
A. Aghamohammadi; K. Imai; K. Moazzami; H. Abolhassani; M. Tabatabaeiyan; N. Parvaneh; R. Nasiri Kalmarzi; N. Nakagawa; K. Oshima; O. Ohara; S. Nonoyama; N. Rezaei - The Zinc Transporter SLC39A13/ZIP13 Is Required for Connective Tissue Development; Its Involvement in BMP/TGF-beta Signaling Pathways
Toshiyuki Fukada; Natacha Civic; Tatsuya Furuichi; Shinji Shimoda; Kenji Mishima; Hiroyuki Higashiyama; Yayoi Idaira; Yoshinobu Asada; Hiroshi Kitamura; Satoru Yamasaki; Shintaro Hojyo; Manabu Nakayama; Osamu Ohara; Haruhiko Koseki; Heloisa G. dos Santos; Luisa Bonafe; Russia Ha-Vinh; Andreas Zankl; Sheila Unger; Marius E. Kraenzlin; Jacques S. Beckmann; Ichiro Saito; Carlo Rivolta; Shiro Ikegawa; Andrea Superti-Furga; Toshio Hirano - Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells
Atsushi Hijikata; Hiroshi Kitamura; Yayoi Kimura; Ryo Yokoyama; Yuichi Aiba; Yanyuan Bao; Shigeharu Fujita; Koji Hase; Shohei Hori; Yasuyuki Ishii; Osami Kanagawa; Hiroshi Kawamoto; Kazuya Kawano; Haruhiko Koseki; Masato Kubo; Ai Kurita-Miki; Tomohiro Kurosaki; Kyoko Masuda; Mitsumasa Nakata; Keisuke Oboki; Hiroshi Ohno; Mariko Okamoto; Yoshimichi Okayama; Jiyang O-Wang; Hirohisa Saito; Takashi Saito; Machie Sakuma; Katsuaki Sato; Kaori Sato; Ken-Ichiro Seino; Ruka Setoguchi; Yuki Tamura; Masato Tanaka; Masaru Taniguchi; Ichiro Taniuchi; Annabelle Teng; Takeshi Watanabe; Hiroshi Watarai; Sho Yamasaki; Osamu Ohara - Integrative annotation of 21,037 human genes validated by full-length cDNA clones
Tadashi Imanishi; Takeshi Itoh; Yutaka Suzuki; Claire O'Donovan; Satoshi Fukuchi; Kanako O. Koyanagi; Roberto A. Barrero; Takuro Tamura; Yumi Yamaguchi-Kabata; Motohiko Tanino; Kei Yura; Satoru Miyazaki; Kazuho Ikeo; Keiichi Homma; Arek Kasprzyk; Tetsuo Nishikawa; Mika Hirakawa; Jean Thierry-Mieg; Danielle Thierry-Mieg; Jennifer Ashurst; Libin Jia; Mitsuteru Nakao; Michael A. Thomas; Nicola Mulder; Youla Karavidopoulou; Lihua Jin; Sangsoo Kim; Tomohiro Yasuda; Boris Lenhard; Eric Eveno; Yoshiyuki Suzuki; Chisato Yamasaki; Jun-Ichi Takeda; Craig Gough; Phillip Hilton; Yasuyuki Fujii; Hiroaki Sakai; Susumu Tanaka; Clara Amid; Matthew Bellgard; Maria de Fatima Bonaldo; Hidemasa Bono; Susan K. Bromberg; Anthony J. Brookes; Elspeth Bruford; Piero Carninci; Claude Chelala; Christine Couillault; Sandro J. de Souza; Marie-Anne Debily; Marie-Dominique Devignes; Inna Dubchak; Toshinori Endo; Anne Estreicher; Eduardo Eyras; Kaoru Fukami-Kobayashi; Gopal R. Gopinath; Esther Graudens; Yoonsoo Hahn; Michael Han; Ze-Guang Han; Kousuke Hanada; Hideki Hanaoka; Erimi Harada; Katsuyuki Hashimoto; Ursula Hinz; Momoki Hirai; Teruyoshi Hishiki; Ian Hopkinson; Sandrine Imbeaud; Hidetoshi Inoko; Alexander Kanapin; Yayoi Kaneko; Takeya Kasukawa; Janet Kelso; Paul Kersey; Reiko Kikuno; Kouichi Kimura; Bernhard Korn; Vladimir Kuryshev; Izabela Makalowska; Takashi Makino; Shuhei Mano; Regine Mariage-Samson; Jun Mashima; Hideo Matsuda; Hans-Werner Mewes; Shinsei Minoshima; Keiichi Nagai; Hideki Nagasaki; Naoki Nagata; Rajni Nigam; Osamu Ogasawara; Osamu Ohara; Masafumi Ohtsubo; Norihiro Okada; Toshihisa Okido; Satoshi Oota; Motonori Ota; Toshio Ota; Tetsuji Otsuki; Dominique Piatier-Tonneau; Annemarie Poustka; Shuang-Xi Ren; Naruya Saitou; Katsunaga Sakai; Shigetaka Sakamoto; Ryuichi Sakate; Ingo Schupp; Florence Servant; Stephen Sherry; Rie Shiba; Nobuyoshi Shimizu; Mary Shimoyama; Andrew J. Simpson; Bento Soares; Charles Steward; Makiko Suwa; Mami Suzuki; Aiko Takahashi; Gen Tamiya; Hiroshi Tanaka; Todd Taylor; Joseph D. Terwilliger; Per Unneberg; Vamsi Veeramachaneni; Shinya Watanabe; Laurens Wilming; Norikazu Yasuda; Sook Hyang-Yoo; Marvin Stodolsky; Wojciech Makalowski; Mitiko Go; Kenta Nakai; Toshihisa Takagi; Minoru Kanehisa; Yoshiyuki Sakaki; John Quackenbush; Yasushi Okazaki; Yoshihide Hayashizaki; Winston Hide; Ranajit Chakraborty; Ken Nishikawa; Hideaki Sugawara; Yoshio Tateno; Zhu Chen; Michio Oishi; Peter Tonellato; Rolf Apweiler; Kousaku Okubo; Lukas Wagner; Stefan Wiemann; Robert L. Strausberg; Takao Isogai; Charles Auffray; Nobuo Nomura; Takashi Gojobori; Sumio Sugano - Directional cDNA library construction assisted by the in vitro recombination reaction
Osamu Ohara; Gary Temple - Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro
Takahiro Nagase; Ken-Ichi Ishikawa; Nobuyuki Miyajima; Ayako Tanaka; Hirokazu Kotani; Nobuo Nomura; Osamu Ohara - Identification of sequence motifs causing band compressions on human cDNA sequencing
Hisashi Yamakawa; Daisuke Nakajima; Osamu Ohara - The role of brain-derived neurotrophic factor in transient forebrain ischemia in the rat brain
Tetsuya Tsukahara; Yasuhiro Yonekawa; Kimito Tanaka; Osamu Ohara; Sachihiko Watanabe; Tetsuya Kimura; Tetsuji Nishijima; Takashi Taniguchi - PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment
Junichiro Takano; Shinsuke Ito; Yixing Dong; Jafar Sharif; Yaeko Nakajima-Takagi; Taichi Umeyama; Yong-Woon Han; Kyoichi Isono; Takashi Kondo; Yusuke Iizuka; Tomohiro Miyai; Yoko Koseki; Mika Ikegaya; Mizuki Sakihara; Manabu Nakayama; Osamu Ohara; Yoshinori Hasegawa; Kosuke Hashimoto; Erik Arner; Robert J. Klose; Atsushi Iwama; Haruhiko Koseki; Tomokatsu Ikawa - Multifaceted analysis of cross-tissue transcriptomes reveals phenotype–endotype associations in atopic dermatitis
Aiko Sekita; Hiroshi Kawasaki; Ayano Fukushima-Nomura; Kiyoshi Yashiro; Keiji Tanese; Susumu Toshima; Koichi Ashizaki; Tomohiro Miyai; Junshi Yazaki; Atsuo Kobayashi; Shinichi Namba; Tatsuhiko Naito; Qingbo S. Wang; Eiryo Kawakami; Jun Seita; Osamu Ohara; Kazuhiro Sakurada; Yukinori Okada; Masayuki Amagai; Haruhiko Koseki - Janus kinase inhibitors ameliorate clinical symptoms in patients with STAT3 gain-of-function
Shuya Kaneko; Fumiaki Sakura; Kay Tanita; Asami Shimbo; Ryusuke Nambu; Masashi Yoshida; Shuichiro Umetsu; Ayano Inui; Chizuru Okada; Miyuki Tsumura; Mamiko Yamada; Hisato Suzuki; Kenjiro Kosaki; Osamu Ohara; Masaki Shimizu; Tomohiro Morio; Satoshi Okada; Hirokazu Kanegane
MISC
- Glycosphingolipid-Binding Proteome Analysis by Affinity Purification-Mass Spectrometry
石川将己; 中島大輔; 紺野亮; 菅野敏生; 遠藤裕介; 小原收; 川島裕介
日本プロテオーム学会大会プログラム・抄録集, 2024 (Web), 2024
Lead - Development of low-input sample preparation method using lauryl maltose neopentyl glycol
紺野亮; 石川将己; 中島大輔; 遠藤裕介; 小原收; 川島祐介
日本プロテオーム学会大会プログラム・抄録集, 2024 (Web), 2024
Lead - Development of an ultra-deep serum/plasma proteome analysis system using lectins
中島大輔; 紺野亮; 石川将己; 宮下靖臣; 宮下靖臣; 小原收; 川島祐介
日本プロテオーム学会大会プログラム・抄録集, 2024 (Web), 2024
Lead - 統合プロテオミクスを用いた小児期シェーグレン症候群の疾患モニタリングとバイオマーカー探索
佐藤 裕範; 伊藤 ありさ; 早田 衣里; 山本 健; 中野 泰至; 山出 史也; 井上 祐三朗; 冨板 美奈子; 川島 祐介; 小原 收; 濱田 洋通
日本小児リウマチ学会総会・学術集会プログラム・抄録集, 32回, 118 - 118, Oct. 2023
Lead - プロテオゲノミクス解析を用いた先天性免疫異常症の遺伝子診断
佐倉 文祥; 野々山 恵章; 今井 耕輔; 大西 秀典; 八角 高裕; 金兼 弘和; 小原 收; 岡田 賢
日本臨床免疫学会総会プログラム・抄録集, 51回, 81 - 81, Oct. 2023
Lead - 次世代新生児スクリーニングに向けた胎動 次世代シーケンシングを越えて
小原 收
日本マス・スクリーニング学会誌, 33(2), 188 - 188, Aug. 2023
Lead - 遺伝学的検査の受託機関から見た今後の課題
小原 收
脳と発達, 55(Suppl.), S233 - S233, May 2023
Lead - 肺血管内皮細胞の炎症応答におけるCD26/DPP4の役割(アンコール演題)
高橋 由希子; 川崎 剛; 佐藤 裕範; 長谷川 嘉則; Dudek Steven M.; 小原 收; 巽 浩一郎; 鈴木 拓児
日本呼吸器学会誌, 12(増刊), 358 - 358, Mar. 2023
Lead - 【腸内細菌を学ぶ】便プロテオーム解析
渡辺 栄一郎; 川島 祐介; 柿原 知; 設樂 佳彦; 斎藤 傑; 香川 礼子; 紺野 亮; 石川 将己; 高見 尚平; 清水 泰岳; 松本 恭明; 福家 辰樹; 高澤 慎也; 西 明; 新井 勝大; 野村 伊知郎; 岡田 賢; 高橋 尚人; 小原 收; 藤代 準
小児外科, 55(2), 150 - 157, Feb. 2023
Lead - 難病領域の遺伝学的検査の実際
細川淳一; 小原收
遺伝子医学, 13(44), 33 - 38, Jan. 2023, Invited
Last - ろ紙血プロテオーム解析を用いたWilson病新規スクリーニング法の可能性
日衛嶋栄太郎; 川島祐介; 仁平寛士; 井澤和司; 児玉浩子; 乾あやの; 東口素子; 滝田順子; 小原収; 八角高裕
日本先天代謝異常学会雑誌, 39, 2023
Lead - Glycosphingolipid-Binding Proteome Analysis by Affinity Purification-Mass Spectrometry
石川将己; 中島大輔; 紺野亮; 小原収; 川島祐介
日本プロテオーム学会大会プログラム・抄録集, 2023 (CD-ROM), 2023
Lead - Development of high-throughput GeLC-MS/MS analysis system for protein complexes
紺野亮; 石川将己; 中島大輔; 小原收; 川島祐介
日本プロテオーム学会大会プログラム・抄録集, 2023 (CD-ROM), 2023
Lead - プロテオーム解析による腸液再注入法の効果の検討
柿原知; 渡辺栄一郎; 高澤慎也; 吉田真理子; 紺野亮; 石川将己; 川島祐介; 小原收; 藤代準
日本小児ストーマ・排泄・創傷管理研究会プログラム・抄録集, 37th, 2023
Lead - Investigation of human-derived proteins specific to children with short bowel syndrome using stool proteome analysis
高澤慎也; 高澤慎也; 渡辺栄一郎; 渡辺栄一郎; 川島祐介; 紺野亮; 石川将己; 柿原知; 柿原知; 吉田真理子; 森田香織; 一瀬諒紀; 泊卓志; 松田理奈; 西明; 小原收; 藤代準
日本プロテオーム学会大会プログラム・抄録集, 2023 (CD-ROM), 2023
Lead - クリオピリン関連周期熱症候群における体細胞モザイク変異率の推移とシングルセル解析による病態解明
加藤 健太郎; 井澤 和司; 本田 吉孝; 宮本 尚幸; 田中 孝之; 山岸 舞; 白崎 善隆; 日衛嶋 栄太郎; 滝田 順子; 小原 收; 八角 高裕; 西小森 隆太
日本小児リウマチ学会総会・学術集会プログラム・抄録集, 31回, 137 - 137, Oct. 2022
Lead - 本邦におけるI型インターフェロンに対する自己抗体とCOVID-19重症化の関連性の検討
江藤 昌平; 津村 弥来; 永島 慎太郎; Bastard Paul; 岡本 圭祐; 鹿島田 健一; 遠藤 明史; 溝口 洋子; 田中 純子; 中釜 悠; 城戸 康年; 貫井 陽子; 今井 耕輔; 金兼 弘和; 小原 收; 森尾 友宏; Casanova Jean-Laurent; 岡田 賢
日本臨床免疫学会総会プログラム・抄録集, 50回, 112 - 112, Oct. 2022
Lead - Pyrinインフラマソームの過剰活性化を原因とする新たな自己炎症性疾患 CDC42 C-term病の病態解析
伊佐 真彦[西谷]; 向井 康治朗; 本田 吉孝; 仁平 寛士; 田中 孝之; 柴田 洋史; 日衛嶋 栄太郎; 井澤 和司; 川崎 ゆり; 大澤 光次郎; 堅田 有宇; 小野寺 幸子; 渡邉 達也; 呉 繁夫; 滝田 順子; 小原 收; 齋藤 潤; 西小森 隆太; 田口 友彦; 笹原 洋二; 八角 高裕
日本免疫不全・自己炎症学会雑誌, 1(2), 70 - 70, Sep. 2022
Lead - 遺伝子構造解析とオミックス解析 臨床応用のための統合化に向けた取り組みの現状と展望
小原 收
日本骨代謝学会学術集会プログラム抄録集, 40回, 76 - 76, Jul. 2022
Lead - ターゲットリシーケンスによる先天性血小板減少症・異常症の原因遺伝子の同定
内山 徹; 小原 收; 要 匡; 笹原 洋二; 國島 伸治; 石黒 精
日本血栓止血学会誌, 33(2), 262 - 262, May 2022
Lead - 遺伝子検査と保険診療 希少難病の遺伝医療と検体検査 現状と課題
小原 收
日本遺伝カウンセリング学会誌, 42(4), 403 - 408, Mar. 2022
Lead - 自己炎症性疾患とその類縁疾患の全国診療体制整備,移行医療体制の構築,診療ガイドライン確立に関する研究 診療ガイドライン/フローチャート作成,遺伝子検査の臨床的妥当性,有用性の評価と遺伝子診断に関する研究
西小森隆太; 井澤和司; 石村匡崇; 石村匡崇; 井田弘明; 伊藤秀一; 今井耕輔; 大西秀典; 岡田賢; 小原收; 金澤伸雄; 金兼弘和; 河合利尚; 川上純; 神戸直智; 岸田大; 笹原洋二; 杉浦一充; 高田英俊; 武井修治; 野々山恵章; 日衛嶋栄太郎; 平家俊男; 右田清志; 宮前多佳子; 向井知之; 盛一享徳; 森尾友宏; 八角高裕; 山田雅文; 和田泰三; 森雅亮; 桐野洋平; 村上良子; 井上徳光; 田中征治; 後藤憲志; 田中悠平; 荒木潤一郎; 日吉祐介; 北城恵史郎; 井出水紀; 山崎聡士; 東口素子; 加藤健太郎; 本田吉孝; 仁平寛士; 伊佐真彦; 前田由可子; 宮本尚幸; 江口克秀; 園田素史; 木下恵志郎; 矢田裕太郎; 足立俊一; 白木真由香; 門脇紗織; 三輪友紀; 土居岳彦; 溝口洋子; 津村弥来; 佐倉文祥; 江藤昌平; 野間康輔; 金城紀子; 石川智朗; 葉山惟大; 国本佳代; 村田顕也; 小野寺雅史; 内山徹; 石川尊士; 岡井真史; 古賀智裕; 伊藤莉子; 村岡勇貴; 松田智子; 北浦次郎; 市川貴規; 福島紘子; 今川和生; 山崎雄一; 関中悠仁; 関中佳奈子; 佐藤秀三; 川邉紀章; 守田吉孝; 清水正樹; 尾崎富美子; 谷田けい; 井上健斗; 友政弾; 竹崎俊一郎; 植木将弘; 信田大喜子; 大畑央樹; シェイマ アブドラブ; 松田裕介
自己炎症性疾患とその類縁疾患の全国診療体制整備、移行医療体制の構築、診療ガイドライン確立に関する研究 令和3年度 総括・分担研究報告書(Web), 2022
Lead - 自己炎症性疾患とその類縁疾患の全国診療体制整備,移行医療体制の構築,診療ガイドライン確立に関する研究 自己炎症性疾患の診療体制の整備,移行期医療に関する研究,関連研究班との連携
西小森隆太; 井澤和司; 石村匡崇; 石村匡崇; 井田弘明; 伊藤秀一; 今井耕輔; 大西秀典; 岡田賢; 小原收; 金澤伸雄; 金兼弘和; 河合利尚; 川上純; 神戸直智; 岸田大; 笹原洋二; 杉浦一充; 高田英俊; 武井修治; 野々山恵章; 日衛嶋栄太郎; 平家俊男; 右田清志; 宮前多佳子; 向井知之; 盛一享徳; 森尾友宏; 八角高裕; 山田雅文; 和田泰三; 森雅亮; 桐野洋平; 村上良子; 井上徳光; 田中征治; 後藤憲志; 田中悠平; 荒木潤一郎; 日吉祐介; 北城恵史郎; 井出水紀; 山崎聡士; 東口素子; 加藤健太郎; 本田吉孝; 仁平寛士; 伊佐真彦; 前田由可子; 宮本尚幸; 江口克秀; 園田素史; 木下恵志郎; 矢田裕太郎; 足立俊一; 白木真由香; 門脇紗織; 三輪友紀; 土居岳彦; 溝口洋子; 津村弥来; 佐倉文祥; 江藤昌平; 野間康輔; 金城紀子; 石川智朗; 葉山惟大; 国本佳代; 村田顕也; 小野寺雅史; 内山徹; 石川尊士; 岡井真史; 古賀智裕; 伊藤莉子; 村岡勇貴; 松田智子; 北浦次郎; 市川貴規; 福島紘子; 今川和生; 山崎雄一; 関中悠仁; 関中佳奈子; 佐藤秀三; 川邉紀章; 守田吉孝; 清水正樹; 尾崎富美子; 谷田けい; 井上健斗; 友政弾; 竹崎俊一郎; 植木将弘; 信田大喜子; 大畑央樹; シェイマ アブドラブ; 松田裕介
自己炎症性疾患とその類縁疾患の全国診療体制整備、移行医療体制の構築、診療ガイドライン確立に関する研究 令和3年度 総括・分担研究報告書(Web), 2022
Lead - 自己炎症性疾患とその類縁疾患の全国診療体制整備,移行医療体制の構築,診療ガイドライン確立に関する研究 自己炎症性疾患の患者登録システムの推進,全国調査に関する研究
西小森隆太; 井澤和司; 石村匡崇; 石村匡崇; 井田弘明; 伊藤秀一; 今井耕輔; 大西秀典; 岡田賢; 小原收; 金澤伸雄; 金兼弘和; 河合利尚; 川上純; 神戸直智; 岸田大; 笹原洋二; 杉浦一充; 高田英俊; 武井修治; 野々山恵章; 日衛嶋栄太郎; 平家俊男; 右田清志; 宮前多佳子; 向井知之; 盛一享徳; 森尾友宏; 八角高裕; 山田雅文; 和田泰三; 森雅亮; 桐野洋平; 村上良子; 井上徳光; 田中征治; 後藤憲志; 田中悠平; 荒木潤一郎; 日吉祐介; 北城恵史郎; 井出水紀; 山崎聡士; 東口素子; 加藤健太郎; 本田吉孝; 仁平寛士; 伊佐真彦; 前田由可子; 宮本尚幸; 江口克秀; 園田素史; 木下恵志郎; 矢田裕太郎; 足立俊一; 白木真由香; 門脇紗織; 三輪友紀; 土居岳彦; 溝口洋子; 津村弥来; 佐倉文祥; 江藤昌平; 野間康輔; 金城紀子; 石川智朗; 葉山惟大; 国本佳代; 村田顕也; 小野寺雅史; 内山徹; 石川尊士; 岡井真史; 古賀智裕; 伊藤莉子; 村岡勇貴; 松田智子; 北浦次郎; 市川貴規; 福島紘子; 今川和生; 山崎雄一; 関中悠仁; 関中佳奈子; 佐藤秀三; 川邉紀章; 守田吉孝; 清水正樹; 尾崎富美子; 谷田けい; 井上健斗; 友政弾; 竹崎俊一郎; 植木将弘; 信田大喜子; 大畑央樹; シェイマ アブドラブ; 松田裕介
自己炎症性疾患とその類縁疾患の全国診療体制整備、移行医療体制の構築、診療ガイドライン確立に関する研究 令和3年度 総括・分担研究報告書(Web), 2022
Lead - Lynch症候群,HBOCに対する千葉県内の診療施設間ネットワーク形成について
松下一之; 松下一之; 松下一之; 松下一之; 栃木透; 宮内英聡; 宮内英聡; 石毛崇之; 糸賀栄; 糸賀栄; 北村浩一; 北村浩一; 西村基; 西村基; 西村基; 西村基; 市川智彦; 市川智彦; 川崎健治; 宇津野恵美; 滝口裕一; 滝口裕一; 野村文夫; 野村文夫; 稲田麻里; 稲田麻里; 横井左奈; 横井左奈; 楯真一; 小原收; 藤木亮次; 藤澤陽子
日本遺伝性腫瘍学会学術集会プログラム・抄録集, 28th, 2022
Lead - Investigation of the usefulness of bile proteome analysis using high-precision mass spectrometry in the search for novel biomarkers of biliary tract cancer.
菅元泰; 千葉哲博; 紺野亮; 中川良; 大山広; 大野泉; 日下部裕子; 高橋幸治; 永嶌裕樹; 三浦義史; 大内麻愉; 川島祐介; 小原収; 加藤直也
日本分子腫瘍マーカー研究会プログラム・講演抄録, 42nd, 2022
Lead - 【理研バイオリソース研究センター20年の歩み】遺伝子リソースの利用者から 遺伝子リソースの利用から細胞の寄託へ ヒト転写因子の網羅的解析を可能にするバイオリソース
秋山 智彦; 中武 悠樹; 洪 繁; 小原 收; 的場 亮; 阿久津 英憲; 西村 邦裕; 洪 実
遺伝: 生物の科学, 75(6), 552 - 559, Nov. 2021
Lead - 【肝胆膵疾患におけるバイオマーカーの意義を探る】胆道疾患のバイオマーカー 胆道閉鎖症の便蛋白/MS解析とバイオマーカーとしての意義
渡辺 栄一郎; 川島 祐介; 柿原 知; 高見 尚平; 高澤 慎也; 小原 收; 藤代 準
肝胆膵, 83(4), 577 - 586, Oct. 2021
Lead - 次世代プロテオミクスを用いた全身型若年性特発性関節炎(sJIA)患者血清における低発現タンパク群の解析
佐藤 裕範; 井上 祐三朗; 川島 祐介; 小原 收; 下条 直樹
日本小児リウマチ学会総会・学術集会プログラム・抄録集, 30回, 137 - 137, Oct. 2021
Lead - オミックス時代の新生児スクリーニングへの展望
小原 收
日本マス・スクリーニング学会誌, 31(2), 193 - 193, Sep. 2021
Lead - 便を用いた網羅的タンパク解析技術・プロテオーム解析を利用した胆道閉鎖症研究
渡辺 栄一郎; 川島 祐介; 須田 亙; 柿原 知; 朝長 高太郎; 星野 論子; 則内 友博; 一城 千都絵; 鈴木 完; 服部 正平; 小原 收; 藤代 準
日本小児外科学会雑誌, 57(4), 787 - 787, Jun. 2021
Lead - 遺伝子検査と保険診療 希少難病の遺伝医療と検体検査 現状と課題
小原 收
日本遺伝カウンセリング学会誌, 42(2), 42 - 42, Jun. 2021
Lead - 先天性血小板減少症・異常症の新しい診断体制とレジストリの確立
石黒 精; 内山 徹; 要 匡; 武部 淳子; 秦 健一郎; 小原 收; 笹原 洋二; 國島 伸治
日本血栓止血学会誌, 32(2), 209 - 209, May 2021
Lead - 基礎研究者と共同して構築した便を対象としたData-independent acquisition mass spectrometry(DIA-MS)ベースプロテオーム解析による胆道閉鎖症の早期診断マーカー探索
渡辺 栄一郎; 川島 祐介; 須田 亙; 柿原 知; 高澤 慎也; 中島 大輔; 中村 蓮; 西 明; 鈴木 完; 小原 収; 藤代 準
日本外科学会定期学術集会抄録集, 121回, SF - 6, Apr. 2021
Lead - 新しい新生児スクリーニングの現状報告
村山 圭; 井上 祐三朗; 糸賀 栄; 小原 收; 羽田 明; 高柳 正樹
日本小児科学会雑誌, 125(4), 670 - 670, Apr. 2021
Lead - オミックス時代の新生児スクリーニングへの技術的展望
小原 收
日本マス・スクリーニング学会誌, 31(3), 277 - 283, Feb. 2021
Lead - MRI検査により早期の拡張型心筋症と考えられた遅発型極長鎖アシルーCoA脱水素酵素欠損症の兄妹例
小野田 幸男; 稲岡 一考; 竹内 真; 笹井 英雄; 深尾 敏幸; 藤木 亮次; 小原 収; 吉長 正博; 谷本 貴志
心臓, 53(2), 209 - 215, Feb. 2021
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J00679&link_issn=&doc_id=20210212180019&doc_link_id=20210212180020&url=http%3A%2F%2Fsearch.jamas.or.jp%2Flink%2Fbc%2F20210212180020&type=jamaslink&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F99999_1.gif
Lead - 変動する医療分野で必要な検査部の多様な役割と課題 ゲノミクス計測の臨床検査への応用可能性と課題
川島 祐介; 小原 收
日本臨床検査医学会誌, 69(1), 19 - 24, Jan. 2021
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J07482&link_issn=&doc_id=20210330460002&doc_link_id=%2Fco3rinsy%2F2021%2F006901%2F002%2F0019-0024%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fco3rinsy%2F2021%2F006901%2F002%2F0019-0024%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
Lead - A study of adenosine deaminase 2 deficiency by multi-omics analysis
仁平寛士; 井澤和司; 加藤健太郎; 宮本尚幸; 前田由可子; 伊佐真彦; 本田吉孝; 日衛嶋栄太郎; 長谷川嘉則; 川島祐介; 金兼弘和; 森尾友宏; 小原收; 西小森隆太; 滝田順子; 八角高裕
日本免疫不全・自己炎症学会総会・学術集会プログラム・抄録集, 4th, 2021
Lead - 子宮上皮Gp130は転写抑制因子Snail1の発現およびエストロゲン応答性の減弱を介してマウス胚着床を誘起する
並木貴文; 唐釜春実; 寺川純平; 大黒多希子; 影山敦子; 長谷川嘉則; 小原収; 伊藤潤哉; 柏崎直巳
日本絨毛性疾患研究会・日本胎盤学会学術集会プログラム・抄録集, 39th-29th, 2021
Lead - 自己炎症性疾患とその類縁疾患の全国診療体制整備,移行医療体制の構築,診療ガイドライン確立に関する研究 自己炎症性疾患の診療ガイドライン/フローチャートの作成に関する研究
西小森隆太; 井澤和司; 石村匡崇; 井田弘明; 伊藤秀一; 今井耕輔; 大西秀典; 岡田賢; 小原收; 金澤伸雄; 金兼弘和; 河合利尚; 川上純; 神戸直智; 岸田大; 笹原洋二; 杉浦一充; 高田英俊; 武井修治; 野々山恵章; 平家俊男; 右田清志; 宮前多佳子; 向井知之; 盛一享徳; 森尾友宏; 八角高裕; 山田雅文; 和田泰三; 田中征治; 後藤憲志; 江口克秀; 幸伏寛和; 薗田素史; 木下恵志郎; 土居岳彦; 溝口洋子; 津村弥来; 佐倉文祥; 江藤昌平; 野間康輔; 市川貴規; 川邉紀章; 守田吉孝; 福島紘子; 今川和生; 古賀智裕; 白木真由香; 門脇紗織; 小野寺雅史; 内山徹; 石川尊士; 岡井真史; 日衛嶋栄太郎; 本田吉孝; 粟屋智就; 阿部純也; 仁平寛士; 伊佐真彦; 前田浩一; 宮本由可子; 金城紀子; 石川智朗; 葉山惟大; 国本佳代; 関中悠仁; 関中佳奈子; 竹崎俊一郎; 植木将弘; 信田大喜子; 大畑央樹; シェイマ アブドラブ; 伊藤莉子; 松田智子; 佐藤秀三; 山崎雄一
自己炎症性疾患とその類縁疾患の全国診療体制整備、移行医療体制の構築、診療ガイドライン確立に関する研究 令和2年度 総括・分担研究報告書(Web), 2021
Lead - 去勢抵抗性前立腺癌を早期に発見するための新規バイオマーカーの開発
若井 健; 米田 慧; 竹内 信善; メイフーラン・マイマイティ; シャムシヤ・アスカル; 東 和彦; 池原 早苗; 山口 高志; 坂本 信一; 小原 收; 山本 一夫; 市川 智彦; 池原 譲
日本分子腫瘍マーカー研究会誌, 36, 15 - 17, 2021
Lead - 最新のマルチオミクス研究と今後の展望 マルチオミックス解析の現状と臨床応用への課題
川島 祐介; 小原 收
電気泳動, 64(Suppl.), s31 - s31, Nov. 2020
Lead - 最新のマルチオミクス研究と今後の展望 マルチオミックス解析の現状と臨床応用への課題
川島 祐介; 小原 收
電気泳動, 64(Suppl.), s31 - s31, Nov. 2020
Lead - 脊髄性筋萎縮症の公的なスクリーニング組み入れを目指して
羽田 明; 稲田 佳美; 安片 恭子; 村山 圭; 高柳 正樹; 糸賀 栄; 細川 淳一; 小原 収; 中村 公俊; 遠藤 文雄
日本マス・スクリーニング学会誌, 30(2), 165 - 165, Sep. 2020
Lead - 便プロテオーム解析を用いた葛西術後の消化管機能に関する研究
三宅 和恵; 渡辺 栄一郎; 川島 祐介; 柿原 知; 高澤 慎也; 西 明; 鈴木 完; 小原 收; 藤代 準
日本小児栄養消化器肝臓学会雑誌, 34(Suppl.), 65 - 65, Sep. 2020
Lead - 去勢抵抗性前立腺癌を早期に発見するための新規バイオマーカーの開発
若井 健; 米田 慧; 竹内 信善; メイフーラン・マイマイティ; シャムシヤ・アスカル; 東 和彦; 池原 早苗; 山口 高志; 坂本 信一; 小原 收; 山本 一夫; 市川 智彦; 池原 譲
日本分子腫瘍マーカー研究会プログラム・講演抄録, 40回, 52 - 54, Sep. 2020
Lead - てんかんにおける遺伝子解析の現状と今後 研究から保険診療への課題 DNAシーケンシングによる希少難病の遺伝学的検査の現状
小原 收
脳と発達, 52(Suppl.), S100 - S100, Aug. 2020
Lead - 【遺伝情報と遺伝カウンセリング】遺伝学的検査の保険制度下での実施にかかわる取り組み
小原 收
小児内科, 52(8), 1128 - 1130, Aug. 2020
Lead - てんかんにおける遺伝子解析の現状と今後 研究から保険診療への課題 DNAシーケンシングによる希少難病の遺伝学的検査の現状
小原 收
脳と発達, 52(Suppl.), S100 - S100, Aug. 2020
Lead - オミックス検査学における質量分析の役割-現状と展望-(4) オミックス検査学の潮流 ゲノムファーストからオミックスファーストへ
川島 祐介; 小原 收
臨床病理, 68(7), 621 - 627, Jul. 2020
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J01563&link_issn=&doc_id=20200821160005&doc_link_id=%2Fco3labor%2F2020%2F006807%2F006%2F0621-0627%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fco3labor%2F2020%2F006807%2F006%2F0621-0627%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
Lead - 【臨床検査からみたタンパク欠損症】タンパク欠損症とオミックス解析
川島 祐介; 小原 收
臨床化学, 49(3), 192 - 198, Jul. 2020
Lead - オミックス検査学における質量分析の役割-現状と展望-(4) オミックス検査学の潮流 ゲノムファーストからオミックスファーストへ
川島 祐介; 小原 收
臨床病理, 68(7), 621 - 627, Jul. 2020
Lead - 次世代シークエンサーを使用する遺伝学的検査の品質課題への対応策
原田 直樹; 小原 収; 要 匡; 堤 正好; 足立 香織; 難波 栄二
日本遺伝カウンセリング学会誌, 41(2), 137 - 137, Jun. 2020
Lead - 指定難病の検査体制に関するアンケート調査
難波 栄二; 足立 香織; 佐藤 万仁; 小原 收; 宮地 勇人; 中山 智祥; 古庄 知己; 原田 直樹; 奥山 虎之; 後藤 雄一
日本遺伝カウンセリング学会誌, 41(2), 137 - 137, Jun. 2020
Lead - 先天性血小板減少症・異常症の新しい診断体制とレジストリの確立
石黒 精; 内山 徹; 要 匡; 川野 布由子; 武部 淳子; 今留 謙一; 秦 健一郎; 松原 洋一; 小原 收; 笹原 洋二; 國島 伸治
日本血栓止血学会誌, 31(2), 243 - 243, May 2020
Lead - 【ビッグデータ時代のゲノム医学】ゲノム医学の進歩 ゲノム医学におけるオミックス解析
小原 收
生体の科学, 71(2), 114 - 118, Apr. 2020, Not invited
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J00731&link_issn=&doc_id=20200423260009&doc_link_id=10.11477%2Fmf.2425201137&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.2425201137&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif
Lead - 遺伝性網膜変性疾患におけるクリニカルシーケンスとその課題
前田 亜希子; 吉田 晶子; 稲葉 慧; 河合 加奈子; 藤木 亮次; 平見 恭彦; 栗本 康夫; 小原 收; 高橋 政代
日本眼科学会雑誌, 124(臨増), 231 - 231, Mar. 2020
Lead - 細胞社会の秩序とアレルギー オミックス計測からのアプローチ
小原 收
日本小児アレルギー学会誌, 34(1), 32 - 36, Mar. 2020
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J02137&link_issn=&doc_id=20200909390003&doc_link_id=%2Fev2areru%2F2020%2F003401%2F003%2F0032-0036%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fev2areru%2F2020%2F003401%2F003%2F0032-0036%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
Lead - 【変わりつつある免疫不全症】免疫不全症の診断 免疫不全症の遺伝子解析の現状と今後
小原 收
小児科診療, 83(3), 315 - 320, Mar. 2020, Not invited
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J00642&link_issn=&doc_id=20200218150004&doc_link_id=%2Fae4shond%2F2020%2F008303%2F005%2F0315b0320%26dl%3D3&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fae4shond%2F2020%2F008303%2F005%2F0315b0320%26dl%3D3&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_4.gif
Lead - 遺伝性網膜変性疾患におけるクリニカルシーケンスとその課題
前田 亜希子; 吉田 晶子; 稲葉 慧; 河合 加奈子; 藤木 亮次; 平見 恭彦; 栗本 康夫; 小原 收; 高橋 政代
日本眼科学会雑誌, 124(臨増), 231 - 231, Mar. 2020, Not invited
Lead - 【変わりつつある免疫不全症】免疫不全症の診断 免疫不全症の遺伝子解析の現状と今後
小原 收
小児科診療, 83(3), 315 - 320, Mar. 2020, Not invited
Lead - ゲノム解析時代のprenatal, newborn screening 新生児スクリーニングのためのオミックス計測技術の最近の進歩
小原 收; 中島 大輔; 川島 祐介
日本小児科学会雑誌, 124(2), 170 - 170, Feb. 2020
Lead - ろ紙血プロテオームを用いた原発性免疫不全症における新生児スクリーニングの可能性
柴田 洋史; 八角 高裕; 前田 由可子; 宮本 尚幸; 伊佐 真彦; 本田 吉孝; 田中 孝之; 井澤 和司; 川島 祐介; 大西 秀典; 石村 匡崇; 今井 耕輔; 小野寺 雅史; 小原 收; 滝田 順子
日本小児科学会雑誌, 124(2), 300 - 300, Feb. 2020
Lead - Cysteinyl leukotriene metabolism of human eosinophils in allergic disease.
Jun Miyata; Koichi Fukunaga; Yusuke Kawashima; Osamu Ohara; Makoto Arita
Allergology international : official journal of the Japanese Society of Allergology, 69(1), 28 - 34, Jan. 2020, Refereed, Not invited
Lead - マルチオミックス解析の現状と臨床応用への課題
川島祐介; 小原收
電気泳動(Web), 64(Suppl), 2020
Lead - DNAメチル化酵素配列特異性変換を伴うピロリ菌エピゲノム・ミクロ進化
福世真樹; 福世真樹; 米澤英雄; 矢野大和; 矢野大和; 桂有加子; 矢原耕史; 今野武津子; 柴田朋子; 重信秀治; BAHITYAR Rahmutulla; 内山郁夫; 長谷川嘉則; 小原收; 金田篤志; 小林一三; 小林一三; 小林一三; 小林一三
日本分子生物学会年会プログラム・要旨集(Web), 43rd, 2020
Lead - DLBCLにおけるFFPE検体を用いたクリニカルシーケンスの実用化についての検討
三科達三; 三科達三; 大島渚; 塚本祥吉; 福世真樹; 影山肇; バハテヤリ ラヒムトラ; 長井友莉恵; 栢森健介; 日野裕太郎; 武藤朋也; 三川紫緒; 三川紫緒; 竹田勇輔; 三村尚也; 三村尚也; 大和田千桂子; 大和田千桂子; 武内正博; 井関徹; 井関徹; 中世古知昭; 中世古知昭; 池田純一郎; 伊丹真紀子; 小原收; 金田篤志; 堺田惠美子; 堺田惠美子
日本血液学会学術集会抄録(Web), 82nd, 2020
Lead - Congenital Neutropenia Caused by SRP54 Mutations
Ayaka Suzawa; Shuhei Krakawa; Satoshi Okada; Satoshi Saito; Shiho Nishimura; Yoshiyuki Kobayashi; Yoko Mizoguchi; Takehiko Doi; Hiroshi Kawaguchi; Chihaya Imai; Osamu Ohara; Masao Kobayashi
PEDIATRIC BLOOD & CANCER, 66, S48 - S48, Dec. 2019
Lead - 多彩な自己炎症性疾患を紐解く インフラマソームを介した自己炎症性疾患の診断・治療にiPS細胞がどのように役立つか?
田中 孝之; 芝 剛; 西小森 隆太; 柴田 洋史; 井澤 和司; 柳町 昌克; 齋藤 潤; 中畑 龍俊; 小原 收; 平家 俊男; 滝田 順子; 八角 高裕
日本小児リウマチ学会総会・学術集会プログラム・抄録集, 29回, 49 - 49, Oct. 2019, Not invited
Lead - プロテオーム解析技術を応用した新たなプロバイオティクスの探索
渡辺 栄一郎; 李 優先; 川島 祐介; 成島 聖子; Sean Kearney; 須田 亙; 服部 正平; 小原 收; 本田 賢也
日本小児栄養消化器肝臓学会雑誌, 33(Suppl.), 108 - 108, Oct. 2019, Not invited
Lead - 新生児マススクリーニング対象先天代謝異常症の遺伝子パネル解析5年間のまとめ
笹井 英雄; 伊藤 哲哉; 但馬 剛; 中村 公俊; 濱崎 考史; 深尾 敏幸; 松本 英樹; 吾郷 耕彦; 細川 淳一; 藤木 亮次; 小原 收; 原 圭一; 中島 葉子; 小林 正久; 市野井 那津子; 坂本 修; 城戸 淳; 松本 志郎; 小林 弘典; 長谷川 有紀
日本マス・スクリーニング学会誌, 29(2), 198 - 198, Oct. 2019, Not invited
Lead - 免疫不全 原発性免疫不全症の遺伝子診断におけるExome解析のpitfallと診断困難例に対する解析戦略 患者由来iPS細胞を用いて診断したDeep intron変異による細胞種依存的なNEMO異常症の経験から
本田 吉孝; 八角 高裕; 伊佐 真彦; 仁平 寛士; 芝 剛; 柴田 洋史; 田中 孝之; 井澤 和司; 川崎 ゆり; 齋藤 潤; 網代 将彦; 萩原 正敏; 岡田 賢; 小原 收; 平家 俊男; 滝田 順子; 西小森 隆太
日本臨床免疫学会総会プログラム・抄録集, 47回, 81 - 81, Oct. 2019, Not invited
Lead - プロテオーム解析技術を応用した新たなプロバイオティクスの探索
渡辺栄一郎; 渡辺栄一郎; 渡辺栄一郎; 李優先; 川島祐介; 川島祐介; 成島聖子; 成島聖子; KEARNEY Sean; KEARNEY Sean; 須田亙; 服部正平; 小原收; 小原收; 本田賢也; 本田賢也
日本小児栄養消化器肝臓学会雑誌, 33(Suppl.), 108 - 108, Oct. 2019, Not invited
Lead - オミックス検査学の潮流:ゲノムファーストからオミックスファーストへ
小原收; 小原收; 小原收
臨床病理, 67(補冊), 033 - 033, Oct. 2019, Not invited
Lead - 細胞社会の秩序とアレルギー:オミックス計測からのアプローチ
小原收; 小原收; 小原收
日本小児アレルギー学会誌, 33(4), 449 - 449, Oct. 2019, Not invited
Lead - GALMの両アレル性変異はガラクトース血症IV型を呈する
和田 陽一; 菊池 敦生; 市野井 那津子; 坂本 修; 岩澤 伸哉; 竹澤 祐介; 新堀 哲也; 入月 浩美; 中島 葉子; 小川 えりか; 石毛 美夏; 平井 洋生; 笹井 英雄; 藤木 亮次; 伊藤 哲哉; 小原 收; 青木 洋子; 深尾 敏幸; 呉 繁夫
日本先天代謝異常学会雑誌, 35, 114 - 114, Sep. 2019
Lead - GALMの両アレル性変異はガラクトース血症IV型を呈する
和田 陽一; 菊池 敦生; 市野井 那津子; 坂本 修; 岩澤 伸哉; 竹澤 祐介; 新堀 哲也; 入月 浩美; 中島 葉子; 小川 えりか; 石毛 美夏; 平井 洋生; 笹井 英雄; 藤木 亮次; 伊藤 哲哉; 小原 收; 青木 洋子; 深尾 敏幸; 呉 繁夫
日本先天代謝異常学会雑誌, 35, 114 - 114, Sep. 2019, Not invited
Lead - 〈Clinical Science〉システム臨床免疫学 遺伝性免疫疾患研究における細胞社会のオミックス解析
小原收; 小原收; 川島祐介; 山岸舞; 白崎善隆; 白崎善隆
炎症と免疫, 27(5), 412 - 416, Aug. 2019, Not invited
Lead - 遺伝性腎疾患:シスチン尿症
市川智彦; 坂本信一; 今村有佑; 梨井隼菱; 小原收
日本腎臓学会誌, 61(6), 697 - 697, Aug. 2019, Not invited
Lead - 【ゲノム医療の社会実装2019-2020】希少疾患のゲノム医療の社会実装 次世代シークエンサー(NGS)による難病等の遺伝学的検査の提供体制
小原 收
臨床病理レビュー, (162), 8 - 14, Jul. 2019, Not invited
Lead - 膜タンパク質に着目した乾燥ろ紙血プロテオーム解析法の開発
中島 大輔; 川島 祐介; 柴田 洋史; 八角 高裕; 伊佐 真彦; 井澤 和司; 西小森 隆太; 平家 俊男; 小原 收
電気泳動, 63(Suppl.), 220 - 220, Jul. 2019, Not invited
Lead - 大規模タンパク解析技術を応用したヒト腸内細菌研究(Proteomic analysis reveals the gut microbiota as a novel regulator of host trypsin protease)
渡辺 栄一郎; 李 優先; 川島 祐介; 成島 聖子; Kearney Sean; 須田 亙; 服部 正平; 小原 收; 本田 賢也
電気泳動, 63(Suppl.), 226 - 226, Jul. 2019, Not invited
Lead - 希少遺伝性疾患の遺伝学的検査の現状
原田 直樹; 小原 收; 要 匡; 古庄 知己; 涌井 敬子; 足立 香織; 難波 栄二
日本遺伝カウンセリング学会誌, 40(2), 176 - 176, Jul. 2019, Not invited
Lead - 膜タンパク質に着目した乾燥ろ紙血プロテオーム解析法の開発
中島 大輔; 川島 祐介; 柴田 洋史; 八角 高裕; 伊佐 真彦; 井澤 和司; 西小森 隆太; 平家 俊男; 小原 收
電気泳動, 63(Suppl.), 220 - 220, Jul. 2019, Not invited
Lead - 大規模タンパク解析技術を応用したヒト腸内細菌研究(Proteomic analysis reveals the gut microbiota as a novel regulator of host trypsin protease)
渡辺 栄一郎; 李 優先; 川島 祐介; 成島 聖子; Kearney Sean; 須田 亙; 服部 正平; 小原 收; 本田 賢也
電気泳動, 63(Suppl.), 226 - 226, Jul. 2019, Not invited
Lead - 家族性腫瘍に対する千葉県内の診療施設間ネットワーク形成について
松下 一之; 石毛 崇之; 宮内 英聡; 糸賀 栄; 宇津野 恵美; 西村 基; 澤井 摂; 稲田 麻里; 横井 左奈; 中津川 智子; 三橋 暁; 小原 收; 野村 文夫; 市川 智彦
日本遺伝カウンセリング学会誌, 40(2), 95 - 95, Jul. 2019, Not invited
Lead - 家族性腫瘍に対する千葉県内の診療施設間ネットワーク形成について
松下 一之; 石毛 崇之; 宮内 英聡; 糸賀 栄; 宇津野 恵美; 西村 基; 澤井 摂; 稲田 麻里; 横井 左奈; 中津川 智子; 三橋 暁; 小原 收; 野村 文夫; 市川 智彦
日本遺伝カウンセリング学会誌, 40(2), 95 - 95, Jul. 2019, Not invited
Lead - 希少疾患のゲノム医療の社会実装 2.次世代シークエンサー(NGS)による難病等の遺伝学的検査の提供体制
小原收
臨床病理レビュー特集, (162), 8 - 14, Jul. 2019, Not invited
Lead - 免疫担当細胞 重症喘息患者の末梢血由来好酸球の炎症フェノタイプの特徴
宮田 純; 持丸 貴生; 奥隅 真一; 川島 祐介; 渡辺 貴志; 小原 収; 有田 誠; 福永 興壱
アレルギー, 68(4-5), 517 - 517, May 2019, Not invited
Lead - DIA分析法を基盤とした高深度プロテオーム解析
川島祐介; 中島大輔; 小原收
質量分析総合討論会講演要旨集, 67th, 158, 26 Apr. 2019, Not invited
Lead - ヒト好酸球のマルチオミクス解析で紐解く、好酸球性副鼻腔炎・重症喘息の分子機序
宮田 純; 川島 祐介; 小原 收; 別役 智子; 福永 興壱; 有田 誠
アレルギー, 68(2), 86 - 91, Mar. 2019, Not invited
Lead - 気管支喘息 病態生理 重症喘息患者の末梢血由来の好酸球の網羅的解析
宮田 純; 持丸 貴生; 奥隅 真一; 川島 祐介; 渡辺 貴志; 小原 収; 有田 誠; 福永 興壱
日本呼吸器学会誌, 8(増刊), 152 - 152, Mar. 2019, Not invited
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J05953&link_issn=&doc_id=20190425110342&doc_link_id=%2Fci6respo%2F2019%2Ft008s1%2F052%2F0152-0152%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fci6respo%2F2019%2Ft008s1%2F052%2F0152-0152%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
Lead - 希少難病の遺伝学的検査を活用していただくために:DNAシーケンシングによる遺伝学的検査の現状と今後の可能性
小原收
臨床小児医学, 66(1-6), 3 - 10, Mar. 2019, Not invited
Lead - 遺伝子変異が同定できない免疫不全症例における、患者iPS細胞を用いた解析例の報告
本田 吉孝; 八角 高裕; 伊佐 真彦; 仁平 寛士; 芝 剛; 下寺 佐栄子; 柴田 洋史; 田中 孝之; 井澤 和司; 川崎 ゆり; 齋藤 潤; 小原 收; 西小森 隆太; 平家 俊男; 滝田 順子
日本小児科学会雑誌, 123(2), 279 - 279, Feb. 2019, Not invited
Lead - p67phox欠損型慢性肉芽腫症におけるp67phox発現と活性酸素産生能
村岡 正裕; 和田 泰三; 白橋 徹志郎; 松田 裕介; 岡本 浩之; 東馬 智子; 小原 收; 谷内江 昭宏
日本小児科学会雑誌, 123(2), 280 - 280, Feb. 2019, Not invited
Lead - GALMの両アレル性変異はガラクトース血症IV型を呈する(Blallelic GALM pathogenic variants cause a novel type of galactosemia)
和田 陽一; 菊池 敦生; 市野井 那津子; 坂本 修; 竹澤 祐介; 岩澤 伸哉; 新堀 哲也; 入月 浩美; 中島 葉子; 小川 えりか; 石毛 美夏; 平井 洋生; 笹井 英雄; 藤木 亮次; 伊藤 哲也; 小原 収; 青木 洋子; 小柴 生造; 深尾 敏幸; 呉 繁夫
日本小児科学会雑誌, 123(2), 280 - 280, Feb. 2019, Not invited
Lead - 遺伝子変異が同定できない免疫不全症例における、患者iPS細胞を用いた解析例の報告
本田 吉孝; 八角 高裕; 伊佐 真彦; 仁平 寛士; 芝 剛; 下寺 佐栄子; 柴田 洋史; 田中 孝之; 井澤 和司; 川崎 ゆり; 齋藤 潤; 小原 收; 西小森 隆太; 平家 俊男; 滝田 順子
日本小児科学会雑誌, 123(2), 279 - 279, Feb. 2019, Not invited
Lead - GALMの両アレル性変異はガラクトース血症IV型を呈する(Blallelic GALM pathogenic variants cause a novel type of galactosemia)
和田 陽一; 菊池 敦生; 市野井 那津子; 坂本 修; 竹澤 祐介; 岩澤 伸哉; 新堀 哲也; 入月 浩美; 中島 葉子; 小川 えりか; 石毛 美夏; 平井 洋生; 笹井 英雄; 藤木 亮次; 伊藤 哲也; 小原 収; 青木 洋子; 小柴 生造; 深尾 敏幸; 呉 繁夫
日本小児科学会雑誌, 123(2), 280 - 280, Feb. 2019, Not invited
Lead - ELANE変異アレル破壊による遺伝子治療の検討
岡田賢; 今中雄介; 津村弥来; 落合博; 中田慎一郎; 小原收; 山本卓; 小林正夫
日本小児科学会雑誌, 123(2), 212 - 212, Feb. 2019, Not invited
Lead - Lynch症候群に対する遺伝子関連検査と診療体制のための診療施設間ネットワーク形成について
松下一之; 松下一之; 石毛崇之; 糸賀栄; 糸賀栄; 澤井摂; 澤井摂; 西村基; 西村基; 中津川智子; 中津川智子; 稲田麻里; 野村文夫; 野村文夫; 内垣洋祐; 宇津野恵美; 小原收; 市川智彦
日本人類遺伝学会大会プログラム・抄録集, 64th, 2019
Lead - 三頭酵素欠損症患者における欠失及びスプライシング異常を誘導する深部イントロン変異の同定
仲間美奈; 仲間美奈; 笹井英雄; 笹井英雄; 窪田満; 長谷川有紀; 藤木亮次; 奥山虎之; 小原收; 深尾敏幸; 深尾敏幸
日本人類遺伝学会大会プログラム・抄録集, 64th, 2019
Lead - 膜タンパク質に着目した乾燥ろ紙血プロテオーム解析法の開発
中島大輔; 川島祐介; 柴田洋史; 八角高裕; 伊佐真彦; 井澤和司; 西小森隆太; 平家俊男; 小原收
日本プロテオーム学会大会プログラム・抄録集, 2019, 2019
Lead - 重症喘息患者の末梢血由来の好酸球の網羅的解析
宮田純; 宮田純; 宮田純; 持丸貴生; 奥隅真一; 川島祐介; 渡辺貴志; 小原収; 有田誠; 有田誠; 福永興壱
日本呼吸器学会誌(Web), 8, 2019
Lead - 保険診療による原発性免疫不全症(PID)の遺伝学的検査の現状
井上 祐三朗; 宇津野 恵美; 西村 基; 内垣 洋祐; 別府 美奈子; 松下 一之; 市川 智彦; 小原 收
日本小児科学会雑誌, 122(12), 1876 - 1876, Dec. 2018, Not invited
Lead - システム臨床免疫学アプローチ 遺伝性免疫疾患研究における細胞社会のオミックス解析
小原 收; 川島 祐介; 山岸 舞; 白崎 善隆
日本臨床免疫学会総会プログラム・抄録集, 46回, 57 - 57, Nov. 2018, Not invited
Lead - Establishment of Diagnostic System, Registry, and Sample Bank for Congenital Thrombocytopenia
Osamu Ohara
Pediatric Blood and Cancer, 55(4), 250 - 250, Oct. 2018, Not invited
https://publons.com/wos-op/publon/19856364/
Lead - 反復性高サイトカイン血症、慢性炎症を呈したKARS遺伝子異常症の1例
仁平 寛士; 井澤 和司; 伊佐 真彦; 芝 剛; 本田 吉孝; 下寺 佐栄子; 柴田 洋史; 田中 孝之; 八角 高裕; 矢野 直子; 舞鶴 賀奈子; 吉田 健司; 横山 淳史; 村山 圭; 小原 収; 西小森 隆太
日本小児リウマチ学会総会・学術集会プログラム・抄録集, 28回, 73 - 73, Oct. 2018, Not invited
Lead - 反復性高サイトカイン血症、慢性炎症を呈したKARS遺伝子異常症の1例
仁平 寛士; 井澤 和司; 伊佐 真彦; 芝 剛; 本田 吉孝; 下寺 佐栄子; 柴田 洋史; 田中 孝之; 八角 高裕; 矢野 直子; 舞鶴 賀奈子; 吉田 健司; 横山 淳史; 村山 圭; 小原 収; 西小森 隆太
日本小児リウマチ学会総会・学術集会プログラム・抄録集, 28回, 111 - 111, Oct. 2018, Not invited
Lead - 学校心臓検診におけるQT延長の指摘から診断に至ったプロピオン酸血症の10歳女児例
笹井 英雄; 後藤 浩子; 川尻 美和; 松本 英樹; 大塚 博樹; 吾郷 耕彦; 藤木 亮次; 小原 收; 深尾 敏幸
日本先天代謝異常学会雑誌, 34, 186 - 186, Sep. 2018, Not invited
Lead - 新生児マススクリーニング検査後のカラム分離による精査から診断に繋がったイソ吉草酸血症保因者の1例
杉山 洋平; 菅原 大輔; 但馬 剛; 藤木 亮次; 小原 收; 笹井 英雄; 深尾 敏幸; 市橋 光
日本先天代謝異常学会雑誌, 34, 230 - 230, Sep. 2018, Not invited
Lead - ヒト化マウスモデルを用いた急性、ならびに慢性移植片対宿主病(GVHD)の病態生理の解明(Understanding pathophysiology of acute and chronic graft-versus-host disease using humanized mice)
小野 林太郎; 渡辺 貴志; 川上 英良; 村澤 麻利子; 松田 正史; 名島 悠峰; 望月 芳樹; 吉田 尚弘; 佐藤 薫; 矢部 普正; 加藤 俊一; 齊藤 頼子; D. Shultz Leonard; 小原 收; 天谷 雅行; 古関 明彦; 石川 文彦
臨床血液, 59(9), 1515 - 1515, Sep. 2018, Not invited
Lead - ケトン性低血糖症を反復し、遺伝子検査でシトリン欠損症と診断された4歳男児
前田 美和子; 清田 今日子; 久我 修二; 笹井 英雄; 深尾 敏幸; 藤木 亮次; 小原 收; 井原 健二
日本小児科学会雑誌, 122(8), 1371 - 1371, Aug. 2018, Not invited
Lead - PKD医学の最先端 次世代シーケンシングを基礎とした遺伝子解析の臨床への利用
小原 收
日本腎臓学会誌, 60(6), 860 - 860, Aug. 2018, Not invited
Lead - 新生児スクリーニングにおける千葉県の取り組み
松永 綾子; 藤浪; 鶴岡 智子; 秋山 奈々; 朽方 豊夢; 倉信 奈緒美; 伏見 拓矢; 小原 収; 大竹 明; 高柳 正樹; 村山 圭
日本マス・スクリーニング学会誌, 28(2), 238 - 238, Jul. 2018, Not invited
Lead - 好酸球性気道疾患 -another "One airway, one disease" Eosinophilic inflammation in respiratory tract -another "One airway, one disease" ヒト好酸球のマルチオミクス解析で紐解く,好酸球性副鼻腔炎・重症喘息の分子機序
宮田 純; 福永 興壱; 川島 祐介; 小原 收; 別役 智子; 有田 誠
アレルギー, 67(4-5), 372 - 372, May 2018, Not invited
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J00009&link_issn=&doc_id=20180601400047&doc_link_id=%2Fcw4aller%2F2018%2F006704%2F050%2F0372-0372%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcw4aller%2F2018%2F006704%2F050%2F0372-0372%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
Lead - 臨床と基礎のteam-up 千葉大学の取り組み
櫻井 大樹; 米田 理葉; 新井 智之; 伊原 史英; 櫻井 利興; 飯沼 智久; 米倉 修二; 花澤 豊行; 小原 收; 中山 俊憲; 岡本 美孝
アレルギー, 67(4-5), 398 - 398, May 2018, Not invited
Lead - 好酸球性気道疾患 -another "One airway, one disease" Eosinophilic inflammation in respiratory tract -another "One airway, one disease" ヒト好酸球のマルチオミクス解析で紐解く,好酸球性副鼻腔炎・重症喘息の分子機序
宮田 純; 福永 興壱; 川島 祐介; 小原 收; 別役 智子; 有田 誠
アレルギー, 67(4-5), 372 - 372, May 2018, Not invited
Lead - 産学連携でのteam-up Team-up by collaboration of universities with industries to develop new treatments for allergic diseases 血液RNAチェックによる健康モニタリングシステムの構築
的場 亮; 野中 謙; 櫻井 大樹; 岡本 美孝; 小原 收
アレルギー, 67(4-5), 386 - 386, May 2018, Not invited
Lead - 臨床と基礎のteam-up 千葉大学の取り組み
櫻井 大樹; 米田 理葉; 新井 智之; 伊原 史英; 櫻井 利興; 飯沼 智久; 米倉 修二; 花澤 豊行; 小原 收; 中山 俊憲; 岡本 美孝
アレルギー, 67(4-5), 398 - 398, May 2018, Not invited
Lead - 膵腫瘍におけるゲノム解析-病態解明と臨床的意義 EUS-FNA検体を用いた切除不能膵癌全エクソンシーケンスおよび全ゲノムコピー数解析
須藤 研太郎; 横井 左奈; 小原 收; 喜多 絵美里; 辻本 彰子; 中村 和貴; 中山 学; 山口 武人
膵臓, 33(3), 359 - 359, May 2018, Not invited
Lead - 原発性マクログロブリン血症およびIgM MGUS患者の末梢血単核球を用いた次世代シーケンサーによるMYD88 L265P遺伝子変異解析
大和田 千桂子; 仲村 彩子; 武内 正博; 竹田 勇輔; 塚本 祥吉; 三村 尚也; 大島 渚; 杉田 泰雅; 田中 宏明; 脇田 久; 青墳 信之; 末永 孝生; 小原 收; 中世古 知昭; 堺田 惠美子
International Journal of Myeloma, 8(2), 102 - 102, May 2018, Not invited
Lead - 原発性マクログロブリン血症およびIgM MGUS患者の末梢血単核球を用いた次世代シークエンサーによるMYD88 L265P遺伝子変異解析
竹田 勇輔; 仲村 彩子; 大和田 千桂子; 武内 正博; 杉田 泰雅; 田中 宏明; 青墳 信之; 末永 孝生; 小原 收; 横手 幸太郎; 堺田 惠美子
日本臨床分子医学会学術総会プログラム・抄録集, 55回, 56 - 56, Apr. 2018, Not invited
Lead - 常染色体優性遺伝形式で3世代にわたり橋本病を発症したA20ハプロ不全症の1家系
堀 友博; 大西 秀典; 門脇 朋範; 川本 典生; 松本 英樹; 小原 收; 深尾 敏幸
日本内分泌学会雑誌, 94(1), 333 - 333, Apr. 2018, Not invited
Lead - オミックス解析からの呼吸器領域へのレッスン 好酸球性炎症性疾患におけるヒト好酸球のマルチオミクス解析
宮田 純; 川島 祐介; 小原 收; 福永 興壱; 有田 誠
日本呼吸器学会誌, 7(増刊), 14 - 14, Mar. 2018, Not invited
Lead - 好酸球性副鼻腔炎患者の鼻茸由来の好酸球の網羅的解析
宮田 純; 福永 興壱; 川島 祐介; 渡辺 貴志; 小原 收; 別役 智子; 有田 誠
日本呼吸器学会誌, 7(増刊), 127 - 127, Mar. 2018, Not invited
Lead - オミックス解析からの呼吸器領域へのレッスン 好酸球性炎症性疾患におけるヒト好酸球のマルチオミクス解析
宮田 純; 川島 祐介; 小原 收; 福永 興壱; 有田 誠
日本呼吸器学会誌, 7(増刊), 14 - 14, Mar. 2018, Not invited
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J05953&link_issn=&doc_id=20180327280017&doc_link_id=%2Fci6respo%2F2018%2F0007s1%2F018%2F0014-0014%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fci6respo%2F2018%2F0007s1%2F018%2F0014-0014%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
Lead - 好酸球性副鼻腔炎患者の鼻茸由来の好酸球の網羅的解析
宮田 純; 福永 興壱; 川島 祐介; 渡辺 貴志; 小原 收; 別役 智子; 有田 誠
日本呼吸器学会誌, 7(増刊), 127 - 127, Mar. 2018, Not invited
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J05953&link_issn=&doc_id=20180327280260&doc_link_id=%2Fci6respo%2F2018%2Fs007s1%2F001%2F0127-0127%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fci6respo%2F2018%2Fs007s1%2F001%2F0127-0127%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
Lead - 絶食負荷による3ヒドロキシ酪酸脱水素酵素(Bdh1)KOマウスの病態解析
大塚 博樹; 木村 豪; 吾郷 耕彦; 仲間 美奈; Abdelkreem Elsayed; 青山 友佳; 笹井 英雄; 大西 秀典; 大沢 匡毅; 川島 祐介; 小原 収; 山口 清次; 深尾 敏幸
日本小児科学会雑誌, 122(2), 240 - 240, Feb. 2018, Not invited
Lead - 15歳時、口腔外科受診を機に診断に至ったChediak-Higashi syndromeの1例
中村 康子; 小倉 友美; 上村 泰弘; 辻 忠孝; 佐藤 泰司; 山内 明; 小原 收; 野々山 恵章
日本小児科学会雑誌, 122(2), 536 - 536, Feb. 2018, Not invited
Lead - 新しい新生児マススクリーニング 新生児マススクリーニングの実現に向けた技術的課題
小原 收
日本小児科学会雑誌, 122(2), 194 - 194, Feb. 2018, Not invited
Lead - 15歳時、口腔外科受診を機に診断に至ったChediak-Higashi syndromeの1例
中村 康子; 小倉 友美; 上村 泰弘; 辻 忠孝; 佐藤 泰司; 山内 明; 小原 收; 野々山 恵章
日本小児科学会雑誌, 122(2), 536 - 536, Feb. 2018, Not invited
Lead - 好酸球性炎症性疾患におけるヒト好酸球のマルチオミクス解析
宮田純; 宮田純; 宮田純; 川島祐介; 小原收; 福永興壱; 有田誠; 有田誠
日本呼吸器学会誌(Web), 7, 2018
Lead - 好酸球性副鼻腔炎患者の鼻茸由来の好酸球の網羅的解析
宮田純; 宮田純; 福永興壱; 川島祐介; 渡辺貴志; 小原收; 別役智子; 有田誠; 有田誠
日本呼吸器学会誌(Web), 7, 2018
Lead - IKZF3ヘテロ接合型ミスセンス変異によるB細胞欠損症
山下基; 満生紀子; 岡田賢; 井上祐三朗; 井上祐三朗; 中世古知昭; 中世古知昭; PADHI Aditya K; ZHANG Kam Y; 小原收; 小原收; 今井耕輔; 今井耕輔; 高木正稔; 高木正稔; 金兼弘和; 谷内一郎; 森尾友宏
日本免疫不全・自己炎症学会総会・学術集会プログラム・抄録集, 1st, 45, 2018, Not invited
http://jglobal.jst.go.jp/public/201802250913081674
Lead - 千葉県における免疫不全・自己炎症診療ネットワーク構築の試み
井上祐三朗; 小原收; 五十嵐俊次; 石和田稔彦; 市川智彦; 角田治美; 朽方豊夢; 下条直樹; 冨板美奈子; 中島裕史; 菱木はるか; 日野もえ子; 星岡明; 星野直; 村山圭; 山出史也
日本免疫不全・自己炎症学会総会・学術集会プログラム・抄録集, 1st, 76, 2018, Not invited
http://jglobal.jst.go.jp/public/201802261471562499
Lead - 液性診断の求める次世代分子計測テクノロジーとは 1細胞分泌実時間イメージングの液性診断への応用
白崎 善隆; 山岸 舞; 鈴木 信勇; 宮田 楓; 田中 優実子; 小原 收; 上村 想太郎
生命科学系学会合同年次大会, 2017年度, [2AW06 - 4], Dec. 2017, Not invited
Lead - 常染色体優性遺伝形式で橋本病を発症したA20ハプロ不全症の1家系
堀 友博; 大西 秀典; 門脇 朋範; 川本 典生; 松本 英樹; 小原 收; 深尾 敏幸
日本内分泌学会雑誌, 93(4), 1131 - 1131, Dec. 2017, Not invited
Lead - Characterization of a Large UNC13D Gene Duplication in a Patient with Familial Hemophagocytic Lymphohistiocytosis Type 3
Hirofumi Shibata; Eitaro Hiejima; Takahiro Yasumi; Saeko Shimodera; Masayuki Hori; Kazushi Izawa; Masaki Matsuoka; Yasuko Kojima; Akira Ohara; Ryuta Nishikomori; Osamu Ohara; Toshio Heike
PEDIATRIC BLOOD & CANCER, 64, S35 - S35, Nov. 2017, Not invited
Lead - 不明熱診療up-to-date 診断応用に向けた先端ゲノミクス技術の活用と今後の展望
小原 收
日本小児リウマチ学会総会・学術集会プログラム・抄録集, 27回, 49 - 49, Oct. 2017, Not invited
Lead - 絶食負荷試験において3ヒドロキシ酪酸脱水素酵素(Bdh1)KOマウスではケトン体産生が障害される
大塚 博樹; 木村 豪; 吾郷 邦彦; 仲間 美奈; Elsayed Abdelkreem; 青山 友佳; 笹井 英雄; 大西 秀典; 大沢 匡毅; 川島 祐介; 小原 収; 山口 清次; 深尾 敏幸
日本先天代謝異常学会雑誌, 33, 164 - 164, Sep. 2017, Not invited
Lead - 本邦での新生児マススクリーニング対象先天代謝異常症の遺伝子パネル解析
笹井 英雄; 藤木 亮次; 小原 收; 中島 葉子; 伊藤 哲哉; 小林 正久; 但馬 剛; 坂本 修; 松本 志郎; 中村 公俊; 濱崎 考史; 小林 弘典; 長谷川 有紀; 深尾 敏幸
日本先天代謝異常学会雑誌, 33, 197 - 197, Sep. 2017, Not invited
Lead - C5-OH高値例の遺伝学的背景に関する検討
長谷川 有紀; 笹井 英雄; 坂本 修; 小林 弘典; 大塚 博樹; 藤木 亮次; 小原 收; 深尾 敏幸
日本先天代謝異常学会雑誌, 33, 199 - 199, Sep. 2017, Not invited
Lead - UNC13D遺伝子のexon duplicationによる家族性血球貪食性リンパ組織球症3型の1例
柴田 洋史; 日衛嶋 栄太郎; 下寺 佐栄子; 井澤 和司; 河合 朋樹; 八角 高裕; 西小森 隆太; 小原 收; 平家 俊男
日本臨床免疫学会会誌, 40(4), 304 - 304, Aug. 2017, Not invited
Lead - 抗IgE抗体CRE-DRを用いたアレルギー様症例ネコ血清中の総IgEの定量測定
熊谷 安希子; 奈良 拓也; 津久井 利広; 山口 佳洋; 長瀬 隆弘; 小原 令子; 小原 收; 前田 貞俊; 増田 健一
日本獣医学会学術集会講演要旨集, 160回, 478 - 478, Aug. 2017, Not invited
Lead - C5-OH値高値症例における遺伝子解析 軽度上昇持続例の遺伝学的背景
長谷川 有紀; 笹井 英雄; 坂本 修; 小林 弘典; 大塚 博樹; 藤木 亮次; 小原 收; 深尾 敏幸
日本マス・スクリーニング学会誌, 27(2), 194 - 194, Jul. 2017, Not invited
Lead - 新生児マススクリーニングでシトルリン高値を示したリポアミド脱水素酵素欠損症の1例
小野 浩明; 川北 理恵; 中村 公俊; 小原 收; 藤木 亮次; 笹井 英雄; 深尾 敏幸; 湯浅 光織; 重松 陽介
脳と発達, 49(Suppl.), S334 - S334, May 2017, Not invited
Lead - 脳室周囲異所性灰白質と結合組織症状を示したFLNA遺伝子変異の女児例
家田 大輔; 堀 いくみ; 中村 勇治; 大下 裕法; 根岸 豊; 篠原 務; 服部 文子; 加藤 丈典; 犬飼 幸子; 北村 勝誠; 國島 伸治; 河合 朋樹; 小原 收; 齋藤 伸治
脳と発達, 49(Suppl.), S423 - S423, May 2017, Not invited
Lead - 微量サンプルを用いたオミックス解析 1細胞実時間回収法によってILC2活性化初期の遺伝子発現動態を網羅的に捉える
白崎 善隆; 田中 優実子; 宮田 楓; 山岸 舞; 鈴木 信勇; 福永 興壱; 別役 智子; 茂呂 和世; 小原 收; 上村 想太郎
日本細胞生物学会大会講演要旨集, 69回, 24 - 24, May 2017, Not invited
Lead - 本邦での新生児マススクリーニング対象先天代謝異常症の遺伝子パネル解析
笹井 英雄; 伊藤 哲哉; 小林 正久; 但馬 剛; 坂本 修; 中村 公俊; 濱崎 考史; 小林 弘典; 長谷川 有紀; 深尾 敏幸; 藤木 亮次; 小原 收; 中島 葉子; 松本 志郎; AMED「新生児タンデムマス; 研究」班
日本小児科学会雑誌, 121(2), 268 - 268, Feb. 2017, Not invited
Lead - 網羅的アラニンスキャニングを用いたSTAT1変異データベースの確立
香川 礼子; 岡田 賢; 藤木 亮次; 津村 弥来; 坂田 園子; 西村 志帆; 加藤 善一郎; 大西 秀典; 小原 收; 小林 正夫
日本小児科学会雑誌, 121(2), 497 - 497, Feb. 2017, Not invited
Lead - 家族性血球貪食症候群3型における新規機能解析法の確立
柴田 洋史; 八角 高裕; 日衛嶋 栄太郎; 下寺 佐栄子; 井澤 和司; 河合 朋樹; 西小森 隆太; 小原 收; 平家 俊男
日本小児科学会雑誌, 121(2), 498 - 498, Feb. 2017, Not invited
Lead - LQT5(KCNE1)D85Nの合併による重症化が推定されたLQT2の1家系
西村基; 西村基; 齋藤直樹; 江畑亮太; 奥主健太郎; 上田希彦; 宇津野恵美; 別府美奈子; 松下一之; 松下一之; 小原收; 田中知明; 田中知明; 小林欣夫; 下条直樹; 市川智彦; 市川智彦
日本遺伝子診療学会大会プログラム・抄録集, 24th, 2017
Lead - 無孔性逆相カラムを用いた高感度プロテオーム解析システムの構築
川島祐介; 小原收; 小原收
日本プロテオーム学会大会プログラム・抄録集, 2017, 2017
Lead - 多施設共同研究によるA20ハプロ不全症の国内症例の病態解析
大西 秀典; 門脇 朋範; 川本 典生; 堀 友博; 西村 謙一; 小林 千恵; 重村 倫成; 緒方 昌平; 井上 祐三朗; 河合 朋樹; 日衛嶋 栄太郎; 高木 正稔; 今井 耕輔; 西小森 隆太; 伊藤 秀一; 平家 俊男; 小原 收; 森尾 友宏; 深尾 敏幸; 金兼 弘和
日本臨床免疫学会会誌, 40(4), 304c - 304c, 2017, Not invited
Lead - Distinctive Genetic Features of Plasma Cells in POEMS Syndrome
Yuhei Nagao; Naoya Mimura; June Takeda; Motohiko Oshima; Kenichi Yoshida; Yusuke Shiozawa; Kazumasa Aoyama; Atsunori Saraya; Shuhei Koide; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Chika Kawajiri-Manako; Nagisa Hasegawa; Shio Sakai; Yusuke Takeda; Chikako Ohwada; Masahiro Takeuchi; Emiko Sakaida; Tohru Iseki; Sonoko Misawa; Koutaro Yokote; Satoru Miyano; Osamu Ohara; Satoshi Kuwabara; Masashi Sanada; Atsushi Iwama; Seishi Ogawa; Chiaki Nakaseko
BLOOD, 128(22), Dec. 2016
Lead - IPEX症候群に骨髄異形成症候群を合併した15歳男児例(IPEX syndrome complicated by myelodysplastic syndrome in a 15-year-old boy)
外山 大輔; 山本 将平; 藤田 祥央; 小金澤 征也; 秋山 康介; 星野 顕宏; 吉田 健一; 満生 紀子; 白石 友一; 千葉 健一; 田中 洋子; 宮野 悟; 小原 収; 高木 正稔; 今井 耕輔; 金兼 弘和; 小川 誠司; 野々山 恵章; 森尾 友宏; 磯山 恵一
日本小児血液・がん学会雑誌, 53(4), 232 - 232, Nov. 2016, Not invited
Lead - 風疹ウイルスワクチン株の持続感染を契機に診断したLIG4欠損症に対し、非血縁者間骨髄移植を施行した一例
松本 和明; 西村 聡; 星野 顕宏; 田中 真理; 山下 基; 下村 真毅; 北澤 宏展; 渡邉 健一郎; 森 嘉生; 加藤 環; 野々山 恵章; 小田 紘嗣; 小原 收; 満生 紀子; 柳町 昌克; 梶原 道子; 今井 耕輔; 高木 正稔; 金兼 弘和; 森尾 友宏
日本小児血液・がん学会雑誌, 53(4), 249 - 249, Nov. 2016, Not invited
Lead - PFAPAの臨床像で発症し、長期経過後に腸管炎症、陰部潰瘍を合併したため診断に至った孤発性のTNFA1P3異常症の1例
本田 吉孝; 河合 朋樹; 西小森 隆太; 八角 高裕; 井澤 和司; 日衛嶋 栄太郎; 中川 権史; 柴田 洋史; 下寺 佐栄子; 大音 泰介; 芝 剛; 仁平 寛士; 小田 紘嗣; 小原 收; 平家 俊男
日本小児リウマチ学会総会・学術集会プログラム・抄録集, 26回, 79 - 79, Oct. 2016, Not invited
Lead - iPS細胞由来Vα24陽性ヒトNKT細胞の抗腫瘍活性の検討
伊豫田 智典; 山田 大輔; 清水 佳奈子; 佐藤 悠輔; 小原 收; 谷口 克; 古関 明彦; 藤井 眞一郎
日本癌学会総会記事, 75回, E - 1064, Oct. 2016, Not invited
Lead - Development of a novel three-dimensional human epidermal model from plucked hair follicle-derived keratinocytes
M. Nakano; N. Kamada; A. Oikawa; C. Shibata; Y. Sasahara; H. Hosokawa; T. Nakayama; K. Nonaka; O. Ohara; Y. Nakamura; H. Matsue
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 136(8), B7 - B7, Aug. 2016, Not invited
Lead - A novel mucosal vaccine targeting Peyer's patch M cells induces protective antigen-specific IgA responses
H. Shima; T. Watanabe; S. Fukuda; S- Fukuoka; O. Ohara; H. Ohno
EUROPEAN JOURNAL OF IMMUNOLOGY, 46, 1225 - 1226, Aug. 2016, Not invited
Lead - 家族性血球貪食症候群(FHL)3型における迅速診断系・機能解析系の確立
柴田 洋史; 八角 高裕; 日衛嶋 栄太郎; 中川 権二; 井澤 和司; 河合 朋樹; 小原 收; 平家 俊男
日本臨床免疫学会会誌, 39(4), 420 - 420, Aug. 2016, Not invited
Lead - 新規抗IgE抗体CRE-DRを用いたイヌ、ネコ、ヒトのアレルゲン特異的IgEの定量測定
熊谷 安希子; 奈良 拓也; 津久井 利広; 鈴木 理恵子; 山口 佳洋; 長瀬 隆弘; 小原 令子; 小原 收; 増田 健一
日本獣医学会学術集会講演要旨集, 159回, 463 - 463, Aug. 2016, Not invited
Lead - 選択的1細胞回収によるNH細胞の2型サイトカイン応答における遺伝子発現解析
田中 優実子; 白崎 善隆; 宮田 楓; 白崎 舞; 鈴木 信勇; 小原 收; 茂呂 和世; 上村 想太郎
日本細胞生物学会大会講演要旨集, 68回, 56 - 56, May 2016, Not invited
Lead - ELISpot/RNA-FISHハイブリット法を用いた細胞密度依存的遺伝子発現誘導機序の解明
山岸 舞; 白崎 善隆; 鈴木 信勇; 小原 收; 上村 想太郎
日本細胞生物学会大会講演要旨集, 68回, 63 - 63, May 2016, Not invited
Lead - NH細胞による2型サイトカイン応答の1細胞分泌動態解析
宮田 楓; 白崎 善隆; 鈴木 信勇; 山岸 舞; 小原 收; 茂呂 和世; 上村 想太郎
日本細胞生物学会大会講演要旨集, 68回, 65 - 65, May 2016, Not invited
Lead - The ORFeome Collaboration: a genome-scale human ORF-clone resource
Stefan Wiemann; Christa Pennacchio; Yanhui Hu; Preston Hunter; Matthias Harbers; Alexandra Amiet; Graeme Bethel; Melanie Busse; Piero Carninci; Mark Diekhans; Ian Dunham; Tong Hao; J. Wade Harper; Yoshihide Hayashizaki; Oliver Heil; Steffen Hennig; Agnes Hotz-Wagenblatt; Wonhee Jang; Anika Joecker; Jun Kawai; Christoph Koenig; Bernhard Korn; Cristen Lambert; Anita LeBeau; Sun Lu; Johannes Maurer; Troy Moore; Osamu Ohara; Jin Park; Andreas Rolfs; Kourosh Salehi-Ashtiani; Catherine Seiler; Blake Simmons; Anja van Brabant Smith; Jason Steel; Lukas Wagner; Tom Weaver; Ruth Wellenreuther; Shuwei Yang; Marc Vidal; Daniela S. Gerhard; Joshua LaBaer; Gary Temple; David E. Hill
NATURE METHODS, 13(3), 191 - 192, Mar. 2016, Not invited
Lead - 重症RSV肺炎を契機に診断された色素失調症を伴う外胚葉形成不全免疫症の男児
山下 文也; 石村 匡崇; 松岡 若利; 園田 素史; 江口 克秀; 小田 紘嗣; 小原 收; 高田 英俊
日本小児科学会雑誌, 120(2), 292 - 292, Feb. 2016, Not invited
Lead - 次世代シーケンシング技術の臨床応用 デジタルカウンティングとシーケンシング
小原 收
アニムス, 21(1), 43 - 50, Jan. 2016, Not invited
Lead - IPEX syndrome complicated by myelodysplastic syndrome in a 15-year-old boy
外山大輔; 山本将平; 藤田祥央; 小金澤征也; 秋山康介; 星野顕宏; 吉田健一; 満生紀子; 白石友一; 千葉健一; 田中洋子; 宮野悟; 宮野悟; 小原収; 高木正稔; 今井耕輔; 金兼弘和; 小川誠司; 野々山恵章; 森尾友宏; 磯山恵一
日本小児血液・がん学会雑誌(Web), 53(4), 2016
Lead - 風疹ウイルスワクチン株の持続感染を契機に診断したLIG4欠損症に対し,非血縁者間骨髄移植を施行した一例
松本和明; 西村聡; 星野顕宏; 田中真理; 山下基; 下村真毅; 北澤宏展; 渡邉健一郎; 森嘉生; 加藤環; 野々山恵章; 小田紘嗣; 小原收; 満生紀子; 柳町昌克; 梶原道子; 今井耕輔; 高木正稔; 金兼弘和; 森尾友宏
日本小児血液・がん学会雑誌(Web), 53(4), 2016
Lead - TRIzol試薬を用いた同一試料からのプロテオーム解析・トランスクリプトーム解析
川島祐介; 宮田純; 有田誠; 有田誠; 小原收; 小原收
質量分析総合討論会講演要旨集, 64th, 2016
Lead - TRIzol試薬による同一試料からのRNA・タンパク質連続抽出法を用いたトランスオミクス解析
川島祐介; 宮田純; 渡辺貴志; 有田誠; 有田誠; 小原收; 小原收
日本プロテオーム学会大会プログラム・抄録集, 2016, 2016
Lead - 軽度T細胞機能不全とNK細胞数減少を呈し,エクソーム解析にてIL2RG新規変異を同定した兄弟例
關中佳奈子; 加藤環; 關中悠仁; 野々山恵章; 今井耕輔; 高島健浩; 大西秀典; 加藤善一郎; 岡本典子; 小原收
日本免疫不全症研究会プログラム・抄録, 9th, 17, 2016, Not invited
http://jglobal.jst.go.jp/public/201602220593518482
Lead - 新規部位特異的組み換え酵素システムVCre/VloxPとSCre/SloxPを利用した哺乳類細胞における高効率遺伝子カセット挿入法
長谷川 嘉則; 渡辺 貴志; 池野 正史; 小原 収; 中山 学
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [3LBA070] - [3LBA070], Dec. 2015, Not invited
Lead - 再生医療への応用を見据えた臨床グレートのヒトiPS細胞由来肝細胞の作製
高山 和雄; 萩原 康子; 関口 清俊; 森尾 友宏; 小原 收; 立花 雅史; 櫻井 文教; 水口 裕之
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [1P0999] - [1P0999], Dec. 2015, Not invited
Lead - iPS細胞技術を利用したNKT細胞再生とがん免疫療法
山田 大輔; 伊豫田 智典; ビスカルド・ラウル; 遠藤 高帆; 小原 收; 藤井 眞一郎; 古関 明彦
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [2P1053] - [2P1053], Dec. 2015, Not invited
Lead - TafazzinトランスアシラーゼドメインにおけるBarth症候群関連変異と選択的スプライシングの構造および機能に対する影響
土方 敦司; 由良 敬; 小原 收; 郷 通子
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [4T18p - 03(3P1259)], Dec. 2015, Not invited
Lead - ラット拡張エクソーム解析の為のプローブデザイン
吉原 美奈子; 小原 收; 庫本 高志; 須山 幹太
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回, [4T18p - 04(3P1260)], Dec. 2015, Not invited
Lead - 自己炎症性疾患の診療における問題点とその解決にむけて 自己炎症性疾患の遺伝子解析
小原 收
日本小児リウマチ学会総会・学術集会プログラム・抄録集, 25回, 68 - 68, Oct. 2015, Not invited
Lead - 本邦でのメバロン酸キナーゼ欠損症のまとめ
田中 孝之; 吉岡 耕平; 酒井 秀政; 西小森 隆太; 阿部 純也; 日衛嶋 栄太郎; 小原 收; 河合 朋樹; 八角 高裕; 平家 俊男
日本小児リウマチ学会総会・学術集会プログラム・抄録集, 25回, 114 - 114, Oct. 2015, Not invited
Lead - 尿細管間質性腎炎を呈しNOD2変異を認めた小児期サルコイドーシスの一例
田中 絵里子; 岡野 翼; 今井 耕輔; 小原 收; 小田 紘嗣; 森 雅亮; 金兼 弘和; 森尾 友宏
日本小児リウマチ学会総会・学術集会プログラム・抄録集, 25回, 149 - 149, Oct. 2015, Not invited
Lead - 妊婦のプレバイオティクス摂取は腸内ビフィズス菌および母乳中IL-27を増加させる
藤田 雄治; 中村 吉孝; 利光 孝之; 横尾 岳大; 久保田 隆之; 小澤 直子; 井上 祐三朗; 野中 謙; 小原 收; 増田 健太郎; 鈴木 修一; 河野 陽一; 下条 直樹
日本小児アレルギー学会誌, 29(4), 594 - 594, Oct. 2015, Not invited
Lead - OXCT1ヘテロキャリアーでもケトアシドーシス発作を起こしうる
笹井 英雄; 青山 友佳; 大塚 博樹; 堀 友博; 藤木 亮次; 小原 收; 深尾 敏幸
日本先天代謝異常学会雑誌, 31, 144 - 144, Oct. 2015, Not invited
Lead - ケトン体利用障害を疑い絶食試験、遺伝子解析により精査したが診断に至っていないケトン性低血糖症の男児例
小川 えりか; 石毛 美夏; 碓井 ひろみ; 米沢 龍太; 笹井 英雄; 深尾 敏幸; 藤木 亮次; 小原 收; 渕上 達夫; 高橋 昌里
日本先天代謝異常学会雑誌, 31, 168 - 168, Oct. 2015, Not invited
Lead - 【電気泳動のフロンティア2015】 ヘテロ核リボヌクレオタンパク質Kの質的変動モニタリング
木村 弥生; 井野 洋子; 戸田 年総; 平野 久; 小原 收
電気泳動, 59(2), 79 - 81, Oct. 2015, Not invited
Lead - ROLES OF B CELL LEUKEMIA/LYMPHOMA 3 IN THE DEVELOPMENT OF T FOLLICULAR HELPER CELLS AND THE PATHOGENESIS OF RHEUMATOID ARTHRITIS
K. Meguro; K. Suzuki; J. Hosokawa; Y. Sanayama; S. Tanaka; S. Furuta; K. Ikeda; H. Takatori; A. Suto; O. Ohara; H. Nakajima
ANNALS OF THE RHEUMATIC DISEASES, 74, 113 - 114, Jun. 2015, Not invited
Lead - アレルギー用語解説シリーズ 次世代シークエンサー
小原 收
アレルギー, 64(6), 822 - 823, Jun. 2015, Not invited
Lead - QT延長症候群遺伝子検査の次世代シーケンサーを用いた立ち上げとこれにより変異同定に至ったJervell and Lange-Nielsen Syndrome(JLNS)の一家系
西村 基; 宇津野 恵美; 上田 希彦; 江畑 亮太; 内海 紀子; 糸賀 栄; 小原 令子; 別府 美奈子; 松下 一之; 小原 收; 野村 文夫
日本遺伝カウンセリング学会誌, 36(2), 120 - 120, May 2015, Not invited
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2015&ichushi_jid=J03823&link_issn=&doc_id=20150609440161&doc_link_id=%2Fdg8genco%2F2015%2F003602%2F0a6%2F0120-0120%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdg8genco%2F2015%2F003602%2F0a6%2F0120-0120%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif
Lead - その他のアレルギー疾患・免疫疾患 IgGサブクラス欠損を示したI型高IgE症候群の1例
金子 英雄; 大西 秀典; 川本 典生; 加藤 善一郎; 小田 紘嗣; 小原 収; 深尾 敏幸
アレルギー, 64(3-4), 491 - 491, Apr. 2015, Not invited
Lead - 【ますます臨床利用が進む遺伝子検査-その現状と今後の展開そして課題-】 (第1章)実用化に向かう次世代シークエンサーとその周辺 遺伝子検査に向けたDNAシークエンス技術の現状と今後の展望
小原 收
遺伝子医学MOOK, (28), 18 - 23, Apr. 2015, Not invited
Lead - Filamin A異常症男性患者の血小板機能評価
小田 紘嗣; 國島 伸治; 鈴木 英紀; 河合 朋樹; 西小森 隆太; 小原 收; 平家 俊男
日本血栓止血学会誌, 26(2), 205 - 205, Apr. 2015, Not invited
Lead - CTLs regulate tumor growth via cytostatic effects rather than cytotoxicity: a few T cells can influence the growth of many times more tumor cells
Kazuhiro Kakimi; Hirokazu Matsushita; Akihiro Hosoi; Manami Miyai; Osamu Ohara
ONCOIMMUNOLOGY, 4(3), Mar. 2015, Not invited
Lead - 1細胞分泌実時間イメージング法
白崎 善隆; 山岸 舞; 小原 收; 上村 想太郎
細胞工学, 34(3), 304 - 309, Feb. 2015, Not invited
Lead - Reply
Yoshie Sanayama; Kei Ikeda; Mieko Yamagata; Shunsuke Furuta; Osamu Ohara; Hiroshi Nakajima
Arthritis and Rheumatology, 66(12), 3524 - 3525, 01 Dec. 2014, Not invited
Lead - Structural bioinformatics in human genetic diseases
Atsushi Hijikata; Osamu Ohara
GENES & GENETIC SYSTEMS, 89(6), 292 - 292, Dec. 2014, Not invited
Lead - Mutations in Bruton's Tyrosine Kinase Impair IgA Responses
N. Mitsuiki; X. Yang; S. Bartol; Y. Kosaka; H. Takada; K. Imai; H. Kanegane; S. Mizutani; M. van der Burg; M. van Zelm; O. Ohara; T. Morio
JOURNAL OF CLINICAL IMMUNOLOGY, 34, S430 - S431, Oct. 2014, Not invited
Lead - B-Precursor Acute Lymphoblastic Leukemia in a Patient with X-Linked Agammaglobulinemia
A. Hoshino; Y. Okuno; M. Migita; H. Ban; X. Yang; N. Kiyokawa; S. Kojima; O. Ohara; H. Kanegane
JOURNAL OF CLINICAL IMMUNOLOGY, 34, S177 - S177, Oct. 2014, Not invited
Lead - Hereditary Folate Malabsorption Due to Novel Compound Heterozygous Mutations in SLC46A1 Exhibiting Severe Combined Immunodeficiency
N. Chida; M. Yamada; K. Kishimoto; R. Kobayashi; K. Kobayashi; O. Ohara; T. Ariga
JOURNAL OF CLINICAL IMMUNOLOGY, 34, S185 - S186, Oct. 2014, Not invited
Lead - 【見逃しやすい免疫不全】 ピンポイント小児医療 遺伝子構造解析の現状とデータ解析アプローチ
小原 收
小児内科, 46(10), 1545 - 1549, Oct. 2014, Not invited
Lead - Activated PI3K-δ syndrome患者の臨床的・免疫学的特徴
高島 健浩; 辻田 由喜; 今井 耕輔; 関中 佳奈子; Yeh Tsu-Wen; 満生 紀子; 奥野 友介; 村松 秀城; 白石 友一; 千葉 健一; 田中 洋子; 宮野 悟; 吉田 健一; 小川 誠司; 金兼 弘和; 小島 勢二; 小原 收; 森尾 友宏; 野々山 恵章
日本臨床免疫学会会誌, 37(4), 350 - 350, Aug. 2014, Not invited
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2014&ichushi_jid=J01882&link_issn=&doc_id=20140908350132&doc_link_id=130004694267&url=http%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F130004694267&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif
Lead - C1qB遺伝子の新規スプライシング異常を認めたC1q欠損症の一家系
樋口 洋介; 清水 順也; 久保 俊英; 浅越 健治; 石村 匡崇; 高田 英俊; 原 寿郎; 小原 收; 北野 悦子; 畑中 道代; 北村 肇
補体, 51(1), 83 - 84, Aug. 2014, Not invited
Lead - 抗原特異的ネコIgE定量測定システムの構築
増田 健一; 岡山 太郎; 津久井 利広; 鈴木 理恵子; 久末 正晴; 山口 佳洋; 長瀬 隆弘; 小原 令子; 小原 收
日本獣医学会学術集会講演要旨集, 157回, 492 - 492, Aug. 2014, Not invited
Lead - PREDICTION OF THERAPEUTIC RESPONSES TO TOCILIZUMAB IN PATIENTS WITH RHEUMATOID ARTHRITIS USING BIOMARKERS IDENTIFIED BY GENOME-WIDE DNA MICROARRAY ANALYSIS IN PERIPHERAL BLOOD MONONUCLEAR CELLS
Y. Sanayama; K. Ikeda; Y. Saito; S. -I. Kagami; M. Yamagata; S. Furuta; D. Kashiwakuma; I. Iwamoto; T. Umibe; Y. Nawata; R. Matsumura; T. Sugiyama; M. Sueishi; M. Hiraguri; K. Nonaka; O. Ohara; H. Nakajima
ANNALS OF THE RHEUMATIC DISEASES, 73, 383 - 383, Jun. 2014, Not invited
Lead - リアルタイム分泌イメージング法を用いたインフラマソーム活性化に伴うIL-1β分泌機序の解析
白崎 善隆; 山岸 舞; 鈴木 信勇; 劉 霆; 山口 良文; 改正 恒康; 星野 克明; 三浦 正幸; 小原 收
日本細胞生物学会大会講演要旨集, 66回, 161 - 161, May 2014, Not invited
Lead - 外胚葉形成不全を伴う免疫異常症EDA-IDの兄妹例
山家 宏宣; 市川 由香里; 島 裕子; 戸川 寛子; 辻 知見; 樋口 隆造; 野々山 恵章; 本間 健一; 釜江 智佳子; 今井 耕輔; 小原 収; 満生 紀子
日本小児科学会雑誌, 118(4), 725 - 725, Apr. 2014, Not invited
Lead - Filamin A異常症患者血小板の形態学的解析
鈴木 英紀; 金澤 彩子; 瀧澤 俊広; 小田 紘嗣; 中川 権史; 井澤 和司; 河合 朋樹; 西小森 隆太; 小原 收; 平家 俊男
日本血栓止血学会誌, 25(2), 289 - 289, Apr. 2014, Not invited
Lead - ヒト免疫とリウマチ性疾患 自己炎症性疾患とリウマチ疾患のcrossroad CINCA症候群/NOMIDの骨幹端過形成をとりあげて
西小森 隆太; 横山 宏司; 梅田 雄嗣; 池谷 真; 中川 権史; 納富 誠司郎; 八角 高裕; 田中 孝之; 齋藤 潤; 小田 紘嗣; 小原 收; 中山 直樹; 戸口田 淳也; 平家 俊男
日本リウマチ学会総会・学術集会プログラム・抄録集, 58回, 206 - 206, Mar. 2014, Not invited
Lead - 自己炎症性疾患における診療研究の新展開 "炎症"と小児発熱性疾患 疾患特異的iPS細胞を用いたCINCA/NOMIDにおける骨幹端過形成の機序解明
西小森 隆太; 横山 宏司; 梅田 雄嗣; 池谷 真; 中川 権史; 納富 誠司郎; 八角 高裕; 田中 孝之; 斉藤 潤; 小田 紘嗣; 小原 収; 中山 直樹; 戸口田 淳也; 平家 俊男
日本小児科学会雑誌, 118(2), 170 - 170, Feb. 2014, Not invited
Lead - 本邦におけるICF症候群5例の検討
釜江 智佳子; 加藤 環; 本間 健一; 小原 收; 今井 耕輔; 久保田 健夫; 野々山 恵章
日本小児科学会雑誌, 118(2), 213 - 213, Feb. 2014, Not invited
Lead - 反復するHenoch-Schoenlein紫斑病を呈したMEFV遺伝子G304R変異型非定型家族性地中海熱
木下 真理子; 西村 豊樹; 澤 大介; 下之段 秀美; 児嶋 ひとみ; 上村 幸代; 盛武 浩; 小原 收; 布井 博幸
日本小児科学会雑誌, 118(2), 262 - 262, Feb. 2014, Not invited
Lead - エクソンスキップに伴い非典型的な表現型を呈したFilamin A異常症の兄弟例
小田 紘嗣; 河合 朋樹; 中川 権史; 日衛嶋 栄太郎; 井澤 和司; 西小森 隆太; 小原 收; 沼部 博直; 平家 俊男
日本小児科学会雑誌, 118(2), 368 - 368, Feb. 2014, Not invited
Lead - IFIH1遺伝子変異はAicardi‐Goutieres症候群の原因となる
ODA HIROTSUGU; NAKAGAWA KENSHI; ABE JUN'YA; AWAYA TOMOYOSHI; FUNAHIKI MASAHIDE; HIJIKATA ATSUSHI; YASUMI TAKAHIRO; SHIRAI TSUYOSHI; OHARA OSAMU; KATO HIROMI; FUJITA TAKASHI; HEIKE TOSHIO
日本遺伝子診療学会大会プログラム・抄録集, 21st, 301, 2014, Not invited
Lead - 家族性弁膜症、腸回転異常症に血小板減少症を合併したFilamin A異常症の兄弟例
小田 紘嗣; 河合 朋樹; 中川 権史; 井澤 和司; 西小森 隆太; 沼部 博直; 鈴木 英紀; 小原 収; 平家 俊男
日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号, 55回・11回・18回, 291 - 291, Nov. 2013, Not invited
Lead - 本邦におけるICF(Immunodeficiency with Centromeric instability and Facial anomalies)症候群5例の検討
加藤 環; 釜江 智佳子; 満生 紀子; 小原 明; 林 正俊; 野口 恵美子; 久保田 健夫; 本間 健一; 小原 収; 今井 耕輔; 野々山 恵章
日本臨床免疫学会会誌, 36(5), 415 - 415, Oct. 2013, Not invited
https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2013&ichushi_jid=J01882&link_issn=&doc_id=20131106410155&doc_link_id=130003383150&url=http%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F130003383150&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif
Lead - Muckle-Wells症候群におけるNLRP3体細胞モザイク変異の検討
中川 権史; 西小森 隆太; 井澤 和司; 河合 朋樹; 八角 高裕; 河合 利尚; 梅林 宏明; 武井 修治; 小林 法元; 小原 收; Gonzalez-Roca Eva; Arostegui Juan I; 平家 俊男
日本臨床免疫学会会誌, 36(5), 390 - 390, Oct. 2013, Not invited
Lead - 一般検査データから見た家族性及び二次性血球貪食性リンパ組織球症の特徴と病態の考察
八角 高裕; 堀 雅之; 井澤 和司; 西小森 隆太; 小原 收; 平家 俊男
日本小児リウマチ学会総会・学術集会プログラム・抄録集, 23回, 84 - 84, Oct. 2013, Not invited
Lead - Muckle-Wells症候群におけるNLRP3体細胞モザイク変異の検討
中川 権史; 西小森 隆太; 井澤 和司; 河合 朋樹; 八角 高裕; 河合 利尚; 梅林 宏明; 武井 修治; 小林 法元; 小原 收; Gonzalez-Roca Eva; Arostegui Juan I; 平家 俊男
日本小児リウマチ学会総会・学術集会プログラム・抄録集, 23回, 126 - 126, Oct. 2013, Not invited
Lead - 細胞傷害活性とIFNγ依存性の細胞周期停止がCTL治療における腫瘍制御のメカニズムである
細井 亮宏; 松下 博和; 上羽 悟史; 前川 隆司; 小原 收; 垣見 和宏
日本がん免疫学会総会プログラム・抄録集, 17回, 104 - 104, Jul. 2013, Not invited
Lead - 毒性オミクス 生体システムダイナミクス理解のための統合ゲノミクス解析の将来展望
小原 收
The Journal of Toxicological Sciences, 38(Suppl.), S149 - S149, Jun. 2013, Not invited
Lead - Killing and IFN-gamma-dependent G1 cell cycle arrest are the mechanisms of regulation of tumor growth by cytotoxic T lymphocytes.
Kakimi Kazuhiro; Hirokazu Matsushita; Akihiro Hosoi; Ryuji Maekawa; Osamu Ohara
CANCER RESEARCH, 73(8), Apr. 2013, Not invited
Lead - 原発性免疫不全症 新しい疾患、トピックス ゲノミクスを基礎とした新しい病因探索法
小原 收
日本小児科学会雑誌, 117(2), 272 - 272, Feb. 2013, Not invited
Lead - 周期性好中球減少症の家族解析で認めたELANE変異モザイクの検討
平田 修; 津村 弥来; 唐川 修平; 岡田 賢; 松村 到; 木村 祐次郎; 小原 收; 小林 正夫
日本小児科学会雑誌, 117(2), 370 - 370, Feb. 2013, Not invited
Lead - 原発性免疫不全症候群(PID)患者支援団体による電子医療記録:Pierの構築
今井 耕輔; 佐藤 弘樹; 野々山 恵章; 宮脇 利男; 原 寿郎; 小原 收
日本小児科学会雑誌, 117(2), 373 - 373, Feb. 2013, Not invited
Lead - 食物アレルギーにおける経口免疫療法の確立と治癒メカニズムの解明に関する研究
竹森利忠; 谷田寿志; 小林夏木; 永岡咲子; 加地友弘; 櫻井友里; 伊藤直香; 石戸晶子; 土方敦司; 渡邊貴志; 小原收; 谷口克; 保坂俊彰; 松田幹; 長尾みづほ; 藤澤隆夫
食物アレルギーにおける経口免疫療法の確立と治癒メカニズムの解明に関する研究 平成22-24年度 総合研究報告書, 27 - 30, 2013, Not invited
http://jglobal.jst.go.jp/public/201302228654075609
Lead - 食物アレルギーにおける経口免疫療法治癒メカニズムの解明に関する研究
竹森利忠; 谷田寿志; 加地友弘; 櫻井友里; 伊藤直香; 石戸晶子; 土方敦司; 渡邊貴志; 小原收; 谷口克; 保坂俊彰; 松田幹; 長尾みづほ; 藤澤隆夫
食物アレルギーにおける経口免疫療法の確立と治癒メカニズムの解明に関する研究 平成24年度 総括・分担研究報告書, 17 - 21, 2013, Not invited
http://jglobal.jst.go.jp/public/201302283078218432
Lead - B細胞分化におけるCCR4‐NOT脱アデニル化酵素複合体サブユニットCNOT3の機能解析
井上毅; 森田斉弘; 足達俊吾; 夏目徹; 深尾太郎; 小原收; 山本雅; 黒崎知博
日本分子生物学会年会プログラム・要旨集(Web), 36th, 1PW5-6 (WEB ONLY), 2013, Not invited
http://jglobal.jst.go.jp/public/201402257764793466
Lead - 鶏卵緩徐免疫療法におけるシンバイオティクス併用によるバイオマーカーの変化
森田 慶紀; 下条 直樹; 中野 泰至; 井上 祐三朗; 有馬 孝恭; 鈴木 修一; 野中 謙; 小原 收; 河野 陽一
アレルギー, 62(9), 1365 - 1365, 2013, Not invited
Lead - NLRP3 SOMATIC MOSAICISM CAN CAUSE MUCKLE-WELLS SYNDROME
K. Izawa; R. Nishikomori; H. Oda; K. Nakagawa; E. Hiejima; K. Yoshioka; J. Abe; T. Kawai; T. Yasumi; T. Heike; A. Hijikata; O. Ohara; M. Saito; T. Nakahata; T. Kawai; S. Takei
JOURNAL OF CLINICAL IMMUNOLOGY, 32, 208 - 208, Sep. 2012, Not invited
Lead - GENETIC ANALYSIS OF AICARDI-GOUTIERES SYNDROME IN JAPAN
J. Abe; R. Nishikomori; K. Izawa; T. Kawai; T. Yasumi; N. Mitsuiki; O. Ohara; I. Toyoshima; K. Hasegawa; H. Ichinose; T. Heike
JOURNAL OF CLINICAL IMMUNOLOGY, 32, 63 - 63, Sep. 2012, Not invited
Lead - CLINICAL FEATURES AND IMMUNOLOGICAL ABNORMALITIES OF GATA2 DEFICIENCY IN JAPAN
K. Honma; K. Imai; C. Kamae; H. Ishida; Y. Ito; S. Kojima; T. Yokosuka; H. Kanegane; T. Morio; Y. Sasahara; T. Fujiwara; H. Harigae; Y. Hashii; O. Ohara; S. Nonoyama
JOURNAL OF CLINICAL IMMUNOLOGY, 32, 84 - 85, Sep. 2012, Not invited
Lead - RAPID DETECTION OF INTRACELLULAR P47PHOX AND P67PHOX BY FLOW CYTOMERY IN PATIENTS WITH CHRONIC GRANULOMATOUS DISEASE
T. Wada; M. Muraoka; T. Toma; T. Shigemura; K. Agematsu; H. Moriuchi; O. Ohara; T. Morio; A. Yachie
JOURNAL OF CLINICAL IMMUNOLOGY, 32, 101 - 101, Sep. 2012, Not invited
Lead - CHRONIC MUCOCUTANEOUS CANDIDIASIS CAUSED BY A GAIN-OF-FUNCTION MUTATION IN THE STAT1 DNA-BINDING DOMAIN
Y. Yamazaki; M. Yamada; S. Takezaki; M. Kato; M-J. Park; K. Maruyama; N. Chida; O. Ohara; I. Kobayashi; T. Ariga
JOURNAL OF CLINICAL IMMUNOLOGY, 32, 100 - 100, Sep. 2012, Not invited
Lead - GENETIC ANALYSIS FOR 207 CASES WITH PRIMARY IMMUNODEFICIENCY (PID) CONSULTED TO A SINGLE CENTER THROUGH PID NETWORK IN JAPAN (PIDJ) IN 5 YEARS (2007-2011)
N. Mitsuiki; K. Oshima; K. Imai; O. Ohara; T. Morio; S. Mizutani
JOURNAL OF CLINICAL IMMUNOLOGY, 32, 227 - 227, Sep. 2012, Not invited
Lead - CLASSIFICATION OF COMMON VARIABLE IMMUNODEFICIENCY BY QUANTIFICATION OF T CELL RECEPTOR RECOMBINATION EXCISION CIRCLES (TREC) AND IG KAPPA-DELETING RECOMBINATION EXCISION CIRCLES (KREC)
C. Kamae; N. Nakagawa; H. Sato; K. Honma; N. Mitsuiki; O. Ohara; H. Kanegane; S. Pasic; Q. Panhammarstrom; M. C. van Zelm; T. Morio; K. Imai; S. Nonoyama
JOURNAL OF CLINICAL IMMUNOLOGY, 32, 256 - 256, Sep. 2012, Not invited
Lead - INDUCED PLURIPOTENT STEM CELLS DERIVED FROM PATIENTS WITH RETICULAR DYSGENESIS
K. Oshima; A. Niwa; K. Imai; S. Nakamura; Y. Jindai; T. Tanaka; M. Yanagimachi; O. Ohara; H. Yabe; S. Kojima; T. Nakahata; S. Nonoyama; M. K. Saito
JOURNAL OF CLINICAL IMMUNOLOGY, 32, 184 - 184, Sep. 2012, Not invited
Lead - 基底核石灰化をともない、進行性の中枢神経障害を来した6ヵ月女児
弓削 康太郎; 大矢 崇志; 澁谷 郁彦; 永光 信一郎; 山下 裕史朗; 松石 豊次郎; 満生 紀子; 小原 収; 阿部 純也; 西小森 隆太; 平家 俊男
脳と発達, 44(5), 412 - 412, Sep. 2012, Not invited
Lead - ADA酵素蛋白の安定性を相乗的に阻害する"WAZA-ARI"変異を認めたADA欠損症の1例
大倉 有加; 山田 雅文; 小林 一郎; SANTISTEBAN I; ARREDONDO-SANTISTEBAN G; 加藤 善一郎; 井口 晶裕; 吉田 真; 小原 収; 中川 紀子; 今井 耕輔; HERSHFIELD MS; 有賀 正
北海道醫學雜誌 = Acta medica Hokkaidonensia, 87(4), 182 - 182, 01 Aug. 2012
Lead - 本邦におけるAicardi-Goutieres症候群の遺伝子解析
西小森 隆太; 阿部 純也; 井澤 和司; 河合 朋樹; 八角 高裕; 満生 紀子; 小原 收; 豊島 至; 長谷川 一子; 一瀬 宏; 平家 俊男
日本臨床免疫学会会誌, 35(4), 328 - 328, Aug. 2012, Not invited
Lead - NLRP3体細胞モザイクを認めたMuckle-Wells症候群の2例
井澤 和司; 土方 敦司; 西小森 隆太; 小原 收; 斎藤 潤; 吉岡 耕平; 堀 雅之; 日衛嶋 栄太郎; 中川 権史; 小田 紘嗣; 阿部 純也; 河合 朋樹; 八角 高裕; 中畑 龍俊; 平家 俊男; 武井 修治; 河合 利尚
日本臨床免疫学会会誌, 35(4), 358 - 358, Aug. 2012, Not invited
Lead - 遺伝子検査にて診断し得た自己炎症症候群の2例
甲斐 基一; 玉置 繁憲; 西小森 隆太; 高岡 優貴; 小原 收; 大嶋 宏一; 北村 政美; 田中 郁子
中部リウマチ, 41(2), 101 - 101, Jul. 2012, Not invited
Lead - 先進ゲノミクスの疾患研究における展開
小原 收
脳と発達, 44(Suppl.), S125 - S125, May 2012, Not invited
Lead - 次世代シーケンサーによるNLRP3体細胞モザイクの検出
井澤和司; 西小森隆太; 日衛嶋栄太郎; 中川権史; 堀雅之; 吉岡耕平; 阿部純也; 河合朋樹; 八角高裕; 平家俊男; 土方敦司; 小原收; 斎藤潤; 中畑龍俊
日本小児遺伝学会学術集会プログラム・抄録集, 35th, 42, 31 Mar. 2012, Not invited
http://jglobal.jst.go.jp/public/201202260660538827
Lead - 原発性免疫不全症における臨床遺伝学 原発性免疫不全症の遺伝子解析ネットワーク
満生 紀子; 小原 收
日本遺伝カウンセリング学会誌, 33(1), 41 - 48, Mar. 2012, Not invited
Lead - 次世代シーケンサーによるNLRP3体細胞モザイクの診断
井澤 和司; 土方 敦司; 西小森 隆太; 小原 收; 田中 尚子; 河合 朋樹; 八角 高裕; 斎藤 潤; 中畑 龍俊; 平家 俊男
日本小児科学会雑誌, 116(2), 258 - 258, Feb. 2012, Not invited
Lead - 【リン酸化生体分子解析のためのフォスタグテクノロジー】 二次元Phos-tag親和性電気泳動
木村 弥生; 永田 佳代子; 平野 久; 小原 收
生物物理化学, 56(Suppl.1), s21 - s24, Jan. 2012, Not invited
Lead - 【リン酸化生体分子解析のためのフォスタグテクノロジー】 Phos-tagアガロースおよび質量分析装置を用いたリン酸化ペプチドのショットガン分析
木村 弥生; 野村 文子; 井野 洋子; 小原 收; 平野 久
生物物理化学, 56(Suppl.1), s25 - s28, Jan. 2012, Not invited
Lead - 原発性免疫不全症候群に関する調査研究 B・NK・DC・単球欠損を伴うGATA2異常症の病態に関する検討
本間健一; 今井耕輔; 釜江智佳子; 石田宏之; 伊藤嘉規; 小島勢二; 横須賀とも子; 金兼弘和; 笹原洋二; 森尾友宏; 渡辺信和; 小原収; 古関明彦; 河本宏; 大嶋宏一; 斉藤潤; 中畑龍俊; 野々山恵章
原発性免疫不全症候群に関する調査研究 平成23年度 総括・分担研究報告書, 73 - 75, 2012, Not invited
http://jglobal.jst.go.jp/public/201202247331157280
Lead - P2-064 NLRP3体細胞モザイクを認めたMuckle-Wells症候群の2例
井澤 和司; 小田 紘嗣; 阿部 純也; 河合 朋樹; 八角 高裕; 中畑 龍俊; 平家 俊男; 武井 修治; 河合 利尚; 土方 敦司; 西小森 隆太; 小原 收; 斎藤 潤; 吉岡 耕平; 堀 雅之; 日衛嶋 栄太郎; 中川 権史
日本臨床免疫学会会誌, 35(4), 358b - 358b, 2012, Not invited
Lead - O51-5 妊婦のプレバイオティクス摂取は母乳中のIL-27を増やす(予知・予防・モニタリング,口演,第62回日本アレルギー学会秋季学術大会)
山本 健; 森田 慶紀; 井上 祐三朗; 有馬 孝恭; 増田 健太郎; 河野 陽一; 久保田 隆之; 下条 直樹; 野中 謙; 山下 政克; 小原 収; 井越 有香; 小澤 直子; 中野 泰至
アレルギー, 61(9), 1532 - 1532, 2012, Not invited
Lead - Membrane-Bound Human Stem Cell Factor Promotes Differentiation of Human Granulocytes and Mast Cells In Vivo
Shinsuke Takagi; Yoriko Saito; Atsushi Hijikata; Satoshi Tanaka; Takashi Watanabe; Haruhiko Koseki; Osamu Ohara; Takashi Saito; Shuichi Taniguchi; Leonard Shultz; Fumihiko Ishikawa
BLOOD, 118(21), 1462 - 1463, Nov. 2011, Not invited
Lead - 造血・免疫系形成 ヒトiPS細胞からのヒトCD34+造血前駆細胞の誘導(Development of human CD34+ hematopoietic progenitors from human iPS cells)
富澤 麻利子; 山田 大輔; 斉藤 頼子; 土方 敦司; 渡辺 貴志; 名島 悠峰; 増田 喬子; 大越 桃子; 河本 宏; 小原 収; 古関 明彦; 石川 文彦
日本免疫学会総会・学術集会記録, 40, 218 - 218, Nov. 2011, Not invited
Lead - マクロファージの新たな機能制御分子による2型糖尿病関連分子の発現調節
北村 浩; 伊藤 誠敏; 木村 俊介; 嶋本 良則; 小林 敦夫; 菊口 千智; 岡部 潤; 渡会 浩志; 小原 收; 三好 一郎
日本獣医学会学術集会講演要旨集, 152回, 322 - 322, Aug. 2011, Not invited
Lead - 原発性免疫不全症における臨床遺伝学 原発性免疫不全症研究の基盤整備
小原 收
日本遺伝カウンセリング学会誌, 32(2), 30 - 30, May 2011, Not invited
Lead - 原発性免疫不全症における臨床遺伝学 原発性免疫不全症研究の基盤整備
小原 收
家族性腫瘍, 11(2), A30 - A30, May 2011, Not invited
Lead - TNFα受容体関連周期性熱症候群(TRAPS)の1例
甲斐 基一; 玉置 繁憲; 西小森 隆太; 高岡 優貴; 小原 收; 大嶋 宏一
リウマチ科, 45(4), 456 - 460, Apr. 2011, Not invited
Lead - NLRP3体細胞モザイクはCINCA症候群の25%以上に認められる
田中 尚子; 井澤 和司; 斎藤 潤; 作間 未織; 大嶋 宏一; 小原 収; 西小森 隆太; 森本 剛; 中畑 龍俊; 平家 俊男
日本小児科学会雑誌, 115(2), 444 - 444, Feb. 2011, Not invited
Lead - 家族性血球貪食性リンパ組織球症2型のCD8+T細胞におけるCD5発現低下
和田 泰三; 榊原 康久; 東馬 智子; 笠原 善仁; 堀田 成紀; 上野 康尚; 八角 高裕; 西 眞範; 小原 收; 谷内江 昭宏
日本小児科学会雑誌, 115(2), 319 - 319, Feb. 2011, Not invited
Lead - NLRP3体細胞モザイクはChronic infantile neurological cutaneous and articular(CINCA)症候群の約25％に認められる
田中尚子; 井澤和司; 斎藤潤; 作間未織; 大嶋宏一; 小原収; 西小森隆太; 森本剛; 神戸直智; 中畑龍俊; 阿部純也; 酒井秀政; 村田祐樹; 河合朋樹; 八角高裕; 平家俊男
厚生労働省難治性疾患克服研究事業 原発性免疫不全症候群に関する調査研究班班会議, Jan. 2011, Not invited
Lead - NEXAFS and XPS studies of VUV/O3 treated aromatic polyurea for high-speed electrophoresis microchips
H. Shinohara; A. Nakahara; S. Shoji; J. Mizuno; Y. Takahashi; F. Kitagawa; K. Otsuka; O. Ohara
NEMS 2011 - 6th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, 1267 - 1271, 2011, Refereed, Not invited
Lead - アレルギーの発症 母乳中細胞遺伝子発現に対する妊婦のプレバイオティクス摂取の効果
久保田 隆之; 下条 直樹; 野中 謙; 山下 政克; 小原 收; 井越 有香; 小澤 直子; 中野 泰至; 森田 慶紀; 井上 祐三朗; 有馬 孝恭; 増田 健太郎; 河野 陽一
アレルギー, 60(9), 1338 - 1338, 2011, Not invited
Lead - ヒト遺伝子クローンを基礎とした産学官連携活動
小原 收
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 83回・33回(プログラム), 482 - 482, Dec. 2010, Not invited
Lead - Sox4によるTh1細胞分化制御の解析
東福寺 聡一; 桑原 誠; 鈴木 淳平; 小原 收; 中山 俊憲; 山下 政克
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 83回・33回, 3T11 - 1, Dec. 2010, Not invited
Lead - プロテインアレイを用いたSH2ドメイン-リン酸化チロシン相互作用の包括的解析
山口 佳洋; 小原 收; 長瀬 隆弘
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 83回・33回, 4P - 0498, Dec. 2010, Not invited
Lead - プロトカドヘリン24は細胞接触依存的にPI3 kinase活性を抑制する
大瀬 塁; 長瀬 隆弘; 小原 收
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 83回・33回, 1P - 0439, Dec. 2010, Not invited
Lead - 新規チオアミド系化合物SH-2251はTh2細胞分化に伴うIL-5遺伝子座のクロマチンリモデリングを阻害する
鈴木 淳平; 東福寺 聡一; 桑原 誠; 今村 匡志; 中山 俊憲; 小原 收; 加藤 文法; 山下 政克
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 83回・33回, 3P - 1032, Dec. 2010, Not invited
Lead - メタボリックシンドロームにおける血中AIMの量的・質的変化に関する解析
新井 郷子; 森田 久美子; 長野 広通; 黒川 淳; 小原 收; 宮崎 徹
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 83回・33回, 3P - 1096, Dec. 2010, Not invited
Lead - IDENTIFICATION OF AML STEM CELL-SPECIFIC THERAPEUTIC TARGETS IN AN IN VIVO MODEL OF HUMAN PRIMARY AML
Y. Saito; H. Kitamura; A. Hijikata; M. Tomizawa-Murasawa; S. Tanaka; S. Takagi; N. Uchida; N. Suzuki; A. Sone; Y. Najima; H. Ozawa; A. Wake; S. Taniguchi; L. D. Shultz; O. Ohara; F. Ishikawa
EXPERIMENTAL HEMATOLOGY, 38(9), S44 - S44, Sep. 2010, Not invited
Lead - ヒト26Sプロテアソームのリン酸化による機能調節
木村 弥生; 永田 佳代子; 菅原 英俊; 井野 洋子; 野村 文子; 小原 收; 鵜殿 平一郎; 平野 久
生物物理化学, 54(Suppl.), 31 - 31, Jul. 2010, Not invited
Lead - T-B plus NK plus Severe Combined Immunodeficiency Caused by a Common Gamma Chain Deficiency
H. Kanegane; U. Koura; H. Sakaki; K. Otsubo; K. Nomura; T. Mario; T. Wada; A. Yachie; K. Oshima; O. Ohara; T. Miyawaki
CLINICAL IMMUNOLOGY, 135(2), 322 - 322, May 2010, Not invited
Lead - 80 Suspected Cases of Primary Immunodeficiency Diseases Through PID Network in Japan (PIDJ) Project for 2 Years
K. Imai; N. Nakagawa; K. Oshima; A. Hijikata; O. Ohara; T. Hara; S. Nonoyama
CLINICAL IMMUNOLOGY, 135(2), 295 - 296, May 2010, Not invited
Lead - Immunoposttranscriptomics マクロファージ様細胞を用いた網羅的な翻訳制御解析を例に
北村 浩; 伊藤 誠敏; 小原 收
日本病態生理学会雑誌, 19(1), 39 - 48, May 2010, Not invited
Lead - 自己炎症症候群の新しい展開 "NLRP3変異陰性"CINCA症候群/NOMIDにおけるNLRP3モザイシズムについて
西小森 隆太; 田中 尚子; 井澤 和司; 斎藤 潤; 八角 高裕; 小原 收; 中畑 龍俊; 平家 俊男
日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, 54回・19回, 209 - 209, Mar. 2010, Not invited
Lead - 高IgD症候群が隠れていませんか? 酵素活性測定法による確定/除外診断法
酒井 秀政; 西小森 隆太; 畑 郁恵; 重松 陽介; 大嶋 宏一; 小原 收; 八角 高裕; 平家 俊男
日本小児科学会雑誌, 114(2), 270 - 270, Feb. 2010, Not invited
Lead - ヒト26Sプロテアソームのリン酸化による機能調節
木村弥生; 永田佳代子; 菅原英俊; 井野洋子; 野村文子; 小原收; 小原收; 鵜殿平一郎; 平野久
生物物理化学(Web), 54(Suppl), 2010
Lead - 原発性免疫不全症候群に関する調査研究 我が国におけるMSMDの臨床像,遺伝学的背景の特徴
高田英俊; 保科隆之; 石村匡崇; 土居岳彦; 原寿郎; 大嶋宏一; 小原收; 金澤崇; 荒川浩一; 西小森隆太; 河合朋樹; 中畑龍俊; 岡田賢; 小林正夫
原発性免疫不全症候群に関する調査研究 平成21年度 総括・分担研究報告書, 71 - 75, 2010, Not invited
http://jglobal.jst.go.jp/public/201002290852587629
Lead - インターフェロンγの投与が有効であったX-linked慢性肉芽腫症の年長女児例
河上 早苗; 田内 久道; 本田 美里; 永井 功造; 石前 峰斉; 江口 真理子; 石井 榮一; 岡田 賢; 小林 正夫; 大嶋 宏一; 小原 收
小児がん, 46(プログラム・総会号), 338 - 338, Nov. 2009, Not invited
Lead - T細胞受容体シグナルと活性化制御 Jurkat細胞において酸性環境下で働くTCRシグナルたんぱく質(TCR signal proteins functioning under acidic environments in Jurkat cells)
王 欣; 深町 利彦; 小原 收; 小林 弘
日本免疫学会総会・学術集会記録, 39, 157 - 157, Nov. 2009, Not invited
Lead - T細胞受容体シグナルと活性化制御 亜鉛シグナルの標的分子の探索と解析
小林 翔平; 古閑 比佐志; 長瀬 隆弘; 大坪 亮太; 熱海 徹; 諸井 亜理紗; 小原 收; 平野 俊夫; 村上 正晃
日本免疫学会総会・学術集会記録, 39, 157 - 157, Nov. 2009, Not invited
Lead - Mendelian susceptibility to Mycobacterial Diseaseの我が国における臨床像と遺伝的背景
高田 英俊; 保科 隆之; 大嶋 宏一; 金澤 崇; 楠原 浩一; 小原 収; 原 寿郎
日本臨床免疫学会会誌, 32(5), 429 - 429, Oct. 2009, Not invited
Lead - Midwinter Seminar 臨床免疫学の未来 Primary Immunodeficiency Database in Japan(PIDJ)プロジェクト開始以来当科へ紹介された原発性免疫不全症(PID)112例に関する検討
中川 紀子; 今井 耕輔; 大嶋 宏一; 小原 收; 野々山 恵章
日本臨床免疫学会会誌, 32(5), 372 - 372, Oct. 2009, Not invited
Lead - リン酸化アフィニティー二次元電気泳動を用いた Heterogeneous nuclear ribonucleoprotein K の質的・量的変動モニタリング
木村 弥生; 永田 佳代子; 鈴木 信勇; 横山 亮; 山中 結子; 平野 久; 北村 浩; 小原 收
生物物理化學, 53(3), 77 - 77, 10 Aug. 2009
Lead - 【免疫不全症候群と遺伝子異常】 免疫不全症候群の遺伝子診断の中央化とデータベース
今井 耕輔; スジャータ・モハン; 小原 收
臨床検査, 53(5), 533 - 540, May 2009, Not invited
Lead - 【免疫不全症候群と遺伝子異常】 免疫不全症の臨床検査 免疫不全症遺伝子解析法の実際
大嶋 宏一; 小原 收
臨床検査, 53(5), 547 - 552, May 2009, Not invited
Lead - PCDH24によるMET-HGFシグナルの抑制はMACC1を介して制御されている可能性がある(The suppression of HGF-MET signaling by PCDH24, might be controlled via MACC1)
大瀬 塁; 池田 俊; 古閑 比佐志; 長瀬 隆弘; 小原 收
日本細胞生物学会大会講演要旨集, 61回, 210 - 210, May 2009, Not invited
Lead - Mina53, an IL4 repressor controlling TH2-bias
Melanie Van Stry; Mariko Okamoto; Madoka Koyanagi; Linda Chung; Yoshie Suzuki; Osamu Ohara; Hiroshi Kitamura; Atsushi Hijikata; Mayumi Tamari; Masato Kubo; Mark Bix
JOURNAL OF IMMUNOLOGY, 182, Apr. 2009, Not invited
Lead - 新規MVK変異による高IgD症候群が疑われる1家系 周期熱の鑑別におけるIgDの役割
酒井 秀政; 水野 隆久; 西小森 隆太; 斎藤 潤; 八角 高裕; 平家 俊男; 小原 收; 荒川 浩一; 中畑 龍俊
日本小児科学会雑誌, 113(2), 312 - 312, Feb. 2009, Not invited
Lead - RAPID (resource of Asian primary immunodeficiency diseases): an open access database for primary immunodeficiency diseases
S. Mohan; S. Keerthikumar; R. Raju; K. Kandasamy; S. Ramabadran; L. Balakrishnan; M. Ahmed; S. Rani; D. Somanathan; S. Ray; Selvan L. Nagarajha; M. Bhatta-Charjee; A. Hijikata; O. Ohara; A. Pandey
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 154, 197 - 197, Nov. 2008, Not invited
Lead - Establishment of Diagnostic center for PID in Japan
S. Nonoyama; K. Imai; O. Ohara; K. Oshima; N. Nakagawa; H. Kanegane; T. Miyawaki; T. Takemori
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 154, 135 - 135, Nov. 2008, Not invited
Lead - プロテオミクス研究最前線 網羅的タンパク質発現リソースからリバースプロテオミクスへの展開 Kazusa ORFeome Project 高付加価値化したヒト遺伝子資源による遺伝子産物機能解析の向上を目指して
長瀬 隆弘; 山川 央; 古閑 比佐志; 小原 收
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 81回・31回, 4S23 - 1, Nov. 2008, Not invited
Lead - Genome-wide characterization of transcripts translationally regulated by bacterial LPS
H. Kitamura; M. Ito; T. Yuasa; C. Kikuguchi; A. Hijikata; O. Ohara
FEBS JOURNAL, 275, 148 - 148, Jun. 2008, Not invited
Lead - Role of JNK in global translation under normal growth conditions
Masatoshi Ito; Hiroshi Kitamura; Chisato Kikuguchi; Tomoko Yuasa; Hiroshi Ohno; Osamu Ohara
FASEB JOURNAL, 22, Apr. 2008, Not invited
Lead - 亜鉛トランスポーターSlc39a13/Zip13の結合組織における機能解析
深田俊幸; 深田俊幸; 古市達哉; 下田信治; 美島健二; 東山浩之; 伊平弥生; 朝田芳信; 北村浩; 山崎哲; 北條慎太郎; 北條慎太郎; 中山学; 小原収; 小原収; 古関明彦; 池川志郎; 平野俊夫; 平野俊夫
生化学, 2008
Lead - 原発性免疫不全症中央診断登録システムの確立
今井 耕輔; 小原 收; 金兼 弘和; 有賀 正; 吉田 真; 遠藤 幹也; 今井 博之; 松原 康策; 西内 律雄; 上野 健太郎; 竹森 利忠; 野々山 恵章; 宮脇 利男
小児がん, 44(プログラム・総会号), 180 - 180, Dec. 2007, Not invited
Lead - マイクロウェルアレイを用いた単一細胞分泌タンパク質解析法の開発(Development of a microscopic platform for analyses of secretory protein at single-cell level using picoliter microwell array)
貴家 康尋; 寺田 佳代子; 大江 良洋; 小原 收; 原田 慶恵
生物物理, 47(Suppl.1), S285 - S285, Nov. 2007, Not invited
Lead - Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system (Vol 21, pg 1857, 2007)
Motoaki Wakiyama; Koji Takimoto; Osamu Ohara; Shigeyuki Yokoyama
GENES & DEVELOPMENT, 21(19), 2509 - 2509, Oct. 2007, Not invited
Lead - 【タンパク質間相互作用】 構造・機能 大きなタンパク分子間の相互作用
小原 收
生体の科学, 58(5), 357 - 359, Oct. 2007, Not invited
Lead - 成体の腸におけるRORgt陽性LTi細胞の役割(The roles of RORgt+ LTi cells in adult gut)
辻 正幸; 鈴木 敬一朗; 北村 浩; 小原 收; 伊藤 喜久治; Fagarasan Sidonia
日本免疫学会総会・学術集会記録, 37, 150 - 150, Oct. 2007, Not invited
Lead - メタノール資化性酵母Pichia pastorisによるGタンパク質共役受容体の網羅的・機能的発現系の構築
大沢登; 小林拓也; 小林拓也; 苫米地由里; 元山かん奈; 外山光俊; 寺田貴帆; 脇山素明; 小原収; 小原収; 田中昭子; 白水美香子; 岩田想; 岩田想; 岩田想; 横山茂之; 横山茂之
生化学, 2007
Lead - SYPRO Ruby染色によって検出されないタンパク質の解析
木村 弥生; 石津 有理; 宇津木 康代; 横山 亮; 澤井 紀子; 土方 敦司; 北村 浩; 小原 收
生物物理化学, 50(3), 119 - 119, Sep. 2006, Not invited
Lead - トランスクリプトーム解析の現状と将来
小原 收
Biotherapy, 20(5), 445 - 451, Sep. 2006, Not invited
Lead - マウスマクロファージの細胞質トランスクリプトーム解析 リポ多糖体の効果
北村 浩; 高山 道代; 中川 朋子; 伊藤 誠敏; 土方 敦司; 木村 弥生; 小原 收
日本獣医学会学術集会講演要旨集, 141回, 259 - 259, Mar. 2006, Not invited
Lead - Identification of pathogenic antigen(s) for type I diabetes
MORI Yoshiko; KATO Takako; YU Xiao Mei; TAKASE Mitsuyo; OHARA Osamu; HIJIKATA Atsushi; SEINO Susumu; KANAGAWA Osami
日本免疫学会総会・学術集会記録, 36, 2006
Lead - 大腸菌LPSのマウスマクロファージ株化細胞のプロテオームに及ぼす効果
木村 弥生; 横山 亮; 石津 有理; 澤井 紀子; 宇津木 康代; 土方 敦司; 北村 浩; 小原 收
生物物理化学, 49(補冊), 28 - 28, Oct. 2005, Not invited
Lead - かずさヒトcDNAマイクロアレイを用いたN-myc標的遺伝子群の検索
小野 さやか; 影山 肇; 中村 洋子; 山川 央; 長瀬 隆弘; 小原 收; 尾崎 俊文; 中川原 章
日本小児血液学会雑誌, 19(5), 370 - 370, Oct. 2005, Not invited
Lead - 【バイオリソースとしてのcDNAフル活用!!】 cDNAプロジェクトの現状とcDNAクローンリソースの利用
長瀬 隆弘; 小原 收
バイオテクノロジージャーナル, 5(5), 626 - 629, Sep. 2005, Not invited
Lead - 【トランスクリプトーム解析の現状と展望】 免疫系のトランスクリプトーム解析の現状と展望
土方 敦司; 北村 浩; 小原 收
臨床免疫, 43(6), 665 - 671, Jun. 2005, Not invited
Lead - 【疾患プロテオミクスの最前線 プロテオミクスで病気を治せるか】 最新疾患プロテオミクス研究の現状と展望 先端ラボ報告 理化学研究所免疫・アレルギー科学総合研究センター
木村 弥生; 北村 浩; 小原 收
遺伝子医学MOOK, (2), 177 - 179, Mar. 2005, Not invited
Lead - 【疾患プロテオミクスの最前線 プロテオミクスで病気を治せるか】 最新プロテオミクス疾患病態解析 免疫疾患のプロテオーム解析 免疫不全症を例として
河野 雅之; 斉藤 隆; 小原 收
遺伝子医学MOOK, (2), 269 - 273, Mar. 2005, Not invited
Lead - Post-transcriptional effects of phorbol 12-myristate 13-acetate on transcriptome of U937 cells (FEBS 29036) (vol 578, pg 180, 2004)
H Kitamura; T Nakagawa; M Takayama; Y Kimura; A Hijikata; O Ohara
FEBS LETTERS, 579(2), 567 - 567, Jan. 2005, Not invited
Lead - OP1-4 かずさヒトcDNAマイクロアレイを用いたN-myc標的遺伝子群の検索(ポスター 神経芽腫1,第21回日本小児がん学会 第47回日本小児血液学会 同時期開催)
小野 さやか; 影山 肇; 中村 洋子; 山川 央; 長瀬 隆弘; 小原 收; 尾崎 俊文; 中川原 章
小児がん : 小児悪性腫瘍研究会記録, 42(3), 609 - 609, 2005
Lead - Interaction of myosin VI with a transmembrane Ser/Thr kinase KPI-2
T Inoue; T Kon; R Ohkura; H Yamakawa; O Ohara; K Sutoh
MOLECULAR BIOLOGY OF THE CELL, 15, 30A - 30A, Nov. 2004, Not invited
Lead - 電気泳動前に行うタンパク質Cys残基の N-ethylmaleimide 修飾による効果
木村 弥生; 横山 亮; 石津 有理; 北村 浩; 小原 収
生物物理化学 = Journal of Electrophoresis, 48, 26 - 26, 15 Oct. 2004
Lead - 免疫ゲノミクス 免疫系の機能ゲノミクス研究
小原 收
感染・炎症・免疫, 34(3), 224 - 225, Sep. 2004, Not invited
Lead - 悪性神経膠腫の予後診断における新たな分子マーカーの検索
小野 さやか; 井内 俊彦; 小牧 久幸; 影山 肇; 中村 洋子; 山川 央; 長瀬 隆弘; 小原 收; 大里 克信; 中川原 章
日本癌学会総会記事, 63回, 451 - 451, Sep. 2004, Not invited
Lead - 乏突起膠腫診断における新たな分子マーカーの検索とその臨床的意義
井内 俊彦; 小牧 久幸; 小野 さやか; 影山 肇; 中村 洋子; 山川 央; 長瀬 隆弘; 小原 收; 大里 克信; 中川原 章
日本癌学会総会記事, 63回, 451 - 451, Sep. 2004, Not invited
Lead - The Kazusa cDNA project for identification of unknown human transcripts (vol 326, pg 959, 2004)
T Nagase; R Kikuno; O Ohara
COMPTES RENDUS BIOLOGIES, 327(8), 773 - 774, Aug. 2004, Not invited
Lead - 【バイオ高性能機器・新技術利用マニュアル】 各種解析装置の原理と使用例 DNAおよびRNA解析装置 DNA/RNA試料調製
北村 浩; 長瀬 隆弘; 小原 收
蛋白質・核酸・酵素, 49(11), 1469 - 1475, Aug. 2004, Not invited
Lead - 遺伝子チップを用いた臨床免疫学研究の最前線 免疫トランスクリプトーム解析の現状
小原 收
日本臨床免疫学会会誌, 27(4), 212 - 213, Aug. 2004, Not invited
Lead - 21世紀医療に叶う抗体医薬の創製とその展望 機能未知巨大蛋白質に対する網羅的抗体作製がもたらすもの
古閑 比佐志; 島田 希代; 原 康洋; 長野 美穂子; 岡崎 規理子; 今井 一英; 甲賀 弘; 川井 誠; 湯浅 茂樹; 菊野 玲子; 小原 令子; 稲本 進; 馬替 純二; 長瀬 隆弘; 小原 收
日本薬学会年会要旨集, 124年会(1), 169 - 169, Mar. 2004, Not invited
Lead - 3P066 ホメオタンパク質に含まれる共通ドメインホメオボックスの分類と代表構造の決定(蛋白質 C) 物性 : 安定性、折れたたみなど)
鎌足 雄司; 近山 英輔; 小柴 生造; 林 文晶; 廣田 洋; 好田 真由美; 井上 真; 矢吹 孝; 青木 雅昭; 関 英子; 寺田 貴帆; 斉藤 講平; 白水 美香子; 田仲 昭子; 小原 収; 菅野 純夫; 関 原明; 篠崎 一雄; 林崎 良英; 川井 悟; 木川 隆則; 横山 茂之; 泉 顕也; Tomo Y; 金野 大助; 中村 安里; 阿部 孝政; 清宮 恭子; 葛西 卓磨; 栃尾 尚哉
生物物理, 44(0), 2004, Not invited
Lead - 樹状細胞によるT細胞活性化におけるERMファミリーの役割
平野 聡; 横須賀 忠; 山崎 晶; 荒瀬 尚; 木村 弥生; 小原 收; 月田 早智子; 月田 承一郎; 斉藤 隆
日本免疫学会総会・学術集会記録, 33, 94 - 94, Nov. 2003, Not invited
Lead - ヒトミオシンVI結合タンパク質の同定及びその機能解析
井上 毅; 昆 隆英; 大倉 玲子; 山川 央; 小原 收; 須藤 和夫
生物物理, 43(Suppl.1), S105 - S105, Aug. 2003, Not invited
Lead - かずさヒトcDNAマイクロアレイを用いたN-myc標的遺伝子の検索
小野 さやか; 小牧 久幸; 影山 肇; 中村 洋子; 山川 央; 長瀬 隆弘; 小原 收; 尾崎 俊文; 崎山 樹; 中河原 章
日本癌学会総会記事, 62回, 475 - 475, Aug. 2003, Not invited
Lead - ミオシンVIとCa2+結合タンパク質NECAB2の相互作用
井上 毅; 昆 隆英; 大倉 玲子; 山川 央; 小原 收; 須藤 和夫
日本細胞生物学会大会講演要旨集, 56回, 27 - 27, May 2003, Not invited
Lead - ヒトミオシンVIと結合する新規タンパク質の同定及びその機能解析
昆 隆英; 井上 毅; 大倉 玲子; 山川 央; 小原 收; 須藤 和夫
日本細胞生物学会大会講演要旨集, 56回, 27 - 27, May 2003, Not invited
Lead - ポストゲノムシークエンス時代におけるcDNA解析の役割
小原 收
日本内分泌学会雑誌, 79(1), 14 - 14, Apr. 2003, Not invited
Lead - Effect of topical steroid on sequential gene expressions for chemokines in mice with contact hypersensitivity.
K Mitsui; G Mitsui; O Ohara; S Yanagihara; M Kato; Y Niwano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 91, 286P - 286P, 2003, Not invited
Lead - Kinetic profiles of sequential expressions for chemokine genes in mice with contact hypersensitivity.
G Mitsui; K Mitsui; T Hirano; O Ohara; M Kato; Y Niwano
JOURNAL OF PHARMACOLOGICAL SCIENCES, 91, 286P - 286P, 2003, Not invited
Lead - トランスクリプトーム・プロテオーム解析による免疫現象解明へのアプローチ
北村浩; 木村弥生; 小原收
BioWave, 26, 18 - 19, 2003, Invited
Lead - 免疫組織に含まれるタンパク質の二次元電気泳動による分析
木村 弥生; 横山 亮; 西垣 聡雄; 北村 浩; 小原 収
生物物理化学, 46, 20 - 20, 15 Oct. 2002
Lead - 医療への応用の可能性 トランスクリプトームからプロテオームへ 哺乳動物プロテオームへのアプローチ
小原 收
医学のあゆみ, 202(5), 364 - 370, Aug. 2002, Not invited
Lead - 【構造プロテオミクス 蛋白質ネットワークの構造生物学】 構造プロテオミクスにおける最新技術 網羅的な蛋白質発現 高分子量蛋白質をコードするヒト長鎖cDNAの解析
小原 收; 長瀬 隆弘; 菊野 玲子; 大石 道夫
蛋白質・核酸・酵素, 47(8), 991 - 996, Jun. 2002, Not invited
Lead - 【プロテオミクスとゲノム創薬】 ヒトcDNA構造解析とゲノム創薬
長瀬 隆弘; 小原 收
Medical Science Digest, 28(5), 178 - 181, May 2002, Not invited
Lead - 新規ADAMTSタンパクをコードするcDNAのクローニング及び機能解析
矢野 和宏; 保田 慎一郎; 村上 弘次; 橋本 英美; 鹿島 亜季子; 神崎 康治; 松永 典子; 岸本 利光; 小原 收; 長瀬 隆弘
Connective Tissue, 34(1), 87 - 87, Apr. 2002, Not invited
Lead - 新規4.1蛋白質,type I brain 4.1,type II brain 4.1のラット脳内局在性について
小原 令子; 山川 央; 中山 学; 湯浅 茂樹; 小原 收
日本細胞生物学会大会講演要旨集, 54回, 99 - 99, May 2001, Not invited
Lead - 睡眠覚醒リズム障害とヒト period3 遺伝子多型との相関
海老沢 尚; 内山 真; 梶村 尚史; 三島 和夫; 亀井 雄一; 加藤 昌明; 渡辺 剛; 関本 正規; 渋井 佳代; 金 圭子; 工藤 吉尚; 尾関 祐二; 杉下 真理子; 豊嶋 良一; 井上 雄一; 山田 尚登; 長瀬 隆弘; 尾崎 紀夫; 小原 収; 石田 直理雄; 大川 匡子; 高橋 清久; 山内 俊雄
日本時間生物学会会誌: Journal of Chronobiology, 6(2), 92 - 92, 01 Oct. 2000
Lead - 大きい蛋白質をコードするヒト脳長鎖cDNAの包括的解析
中山 学; 長瀬 隆弘; 菊野 玲子; 小原 收
神経化学, 39(3), 240 - 240, Oct. 2000, Not invited
Lead - 細胞膜を内側から支える仕組み 4.1蛋白質ファミリーの多様性と機能分担
山川 央; 小原 令子; 中山 学; 小原 收
膜, 25(4), 161 - 162, Jul. 2000, Not invited
Lead - RT-PCR ELISA法を用いた遺伝子発現プロファイルの解析
長瀬 隆弘; 小原 收
日本時間生物学会会誌: Journal of Chronobiology, 6(1), 44 - 53, 01 May 2000
Lead - 【ゲノム医学の現在と未来】 cDNA ヒト長鎖cDNA解析
小原 收
現代医療, 32(1), 78 - 83, Jan. 2000, Not invited
Lead - Molecular characterization of a new member of the protein 4.1 family (brain 4.1) in rat brain (vol 70, pg 197, 1999)
H Yamakawa; R Ohara; D Nakajima; M Nakayama; O Ohara
MOLECULAR BRAIN RESEARCH, 74(1-2), 247 - 247, Dec. 1999, Not invited
Lead - Cerebellum-specific expression of MEGF1/fat2, an enormous protein containing EGF-like and cadherin motifs, identified by the Motif-trap screening
NAKAJIMA Daisuke; OHARA Osamu; NAKAYAMA Manabu
日本分子生物学会年会プログラム・講演要旨集, 21, 655 - 655, 01 Dec. 1998
Lead - Functional analysis of MEGF1/fat2 product and its putative role in parallel fibers of cerebellar granule cells
NAKAYAMA Manabu; NAKAJIMA Daisuke; OHARA Osamu
日本分子生物学会年会プログラム・講演要旨集, 21, 655 - 655, 01 Dec. 1998
Lead - Grouping of human long cDNAs and sequence comparison with the genomes of nematode and yeast
KIKUNO Reiko; SUYAMA Mikita; NAGASE Takahiro; ISHIKAWA Ken-ichi; OHARA Osamu; NOMURA Nobuo
日本分子生物学会年会プログラム・講演要旨集, 21, 252 - 252, 01 Dec. 1998
Lead - Construction of a database for proteins encoded by relatively long human cDNA clones and its use
SUYAMA Mikita; HIROSAWA Makoto; ISHIKAWA Ken-Iichi; NAGASE Takahiro; OHARA Osamu
日本分子生物学会年会プログラム・講演要旨集, 21, 253 - 253, 01 Dec. 1998
Lead - Complete sequencing of relatively long human cDNA clones derived from brain
ISHIKAWA K. -I.; NAGASE T.; NAKAJIMA D.; SUYAMA M.; KIKUNO R.; MIYAJIMA N.; NOMURA N.; OHARA O.
日本分子生物学会年会プログラム・講演要旨集, 21, 252 - 252, 01 Dec. 1998
Lead - Kazusa human cDNA project : Complete sequencing of 1000 human long cDNAs
NOMURA Nobuo; NAGASE Takahiro; ISHIKAWA Ken-ichi; KIKUNO Reiko; MIYAJIMA Nobuyuki; OHARA Osamu
日本分子生物学会年会プログラム・講演要旨集, 21, 252 - 252, 01 Dec. 1998
Lead - Detection of spurious interruption of the protein coding sequence in a human brain long cDNA clone by GeneMark-RC Program
HIROSAWA Makoto; NAGASE Takahiro; OHARA Osamu
日本分子生物学会年会プログラム・講演要旨集, 21, 252 - 252, 01 Dec. 1998
Lead - Cellular and subcellular localization of newly characterized 4.1 membrane skeletal protein in rat brain
OHARA Reiko; YAMAKAWA Hisashi; NAKAYAMA Manabu; YUASA Shigeki; OHARA Osamu
日本分子生物学会年会プログラム・講演要旨集, 21, 485 - 485, 01 Dec. 1998
Lead - Molecular characterization of novel protein 4.1 genes identified by comprehensive analysis of human large cDNAs
YAMAKAWA Hisashi; OHARA Reiko; NAKAJIMA Daisuke; NAKAYAMA Manabu; OHARA Osamu
日本分子生物学会年会プログラム・講演要旨集, 21, 484 - 484, 01 Dec. 1998
Lead - 哺乳類のperホモログ(rPer2)遺伝子の発現リズムとSCN破壊ラットでの動態
坂本 克彦; 長瀬 隆弘; 福井 広美; 堀川 和政; 岡田 哲也; 田中 均; 佐藤 和雄; 三宅 良明; 小原 収; 加香 孝一郎; 石田 直理雄
日本時間生物学会会誌: Journal of Chronobiology, 4(2), 125 - 125, 01 Oct. 1998
Lead - Prediction of domain boundaries in proteins.
Suyama M.; Ohara O.
Biophysics, 38(2), S149, 07 Sep. 1998
Lead - 【脱アイソトープ実践プロトコール キット簡単編】 発現をみる 酵素直接標識法を用いたノーザンハイブリダイゼーション
中島 大輔; 小原 收
細胞工学, 別冊(脱アイソトープ実戦プロトコール), 79 - 87, Apr. 1998, Not invited
Lead - Single molecular assay of the individual ATP turnovers by a myosin-GFP fusion protein expressed in vitro
AH Iwane; T Funatsu; Y Harada; M Tokunaga; O Ohara; T Yanagida
BIOPHYSICAL JOURNAL, 74(2), A260 - A260, Feb. 1998, Not invited
Lead - ヒト長鎖cDNAの全長シ-クエンス解析(ヒト--cDNAからのアプロ-チ) (ゲノムサイエンス--生命の全体像の解明をめざして) -- (第1部 日本におけるヒト・ゲノム研究の最前線)
小原 収; 長瀬 隆弘; 野村 信夫
蛋白質核酸酵素, 42(17), 2851 - 2857, Dec. 1997
Lead - Individual ATPase assay and in vitro expression of myosin-GFP fused protein
H. IWANE A.; FUNATSU T.; HARADA Y.; OHARA O.; YANAGIDA T.
Biophysics, 37, S211, Oct. 1997
Lead - Analysis of rat new genes that encode membrane-skeleton proteins
OHARA O.; YAMAKAWA H.; OHARA R.; NAKAJIMA D.; NAKAYAMA M.
Biophysics, 37, S193, Oct. 1997
Lead - Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain (supplement)
Takahiro Nagase; Naohiko Seki; Ken-Ichi Ishikawa; Miki Ohira; Yutaka Kawarabayasi; Osamu Ohara; Ayako Tanaka; Hirokazu Kotani; Nobuyuki Miyajima; Nobuo Nomura
DNA Research, 3(5), 341 - 354, 1996, Not invited
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0000711777&origin=inward
Lead - Biological functions of neurofilaments in the nervous system
O. Ohara; T. Kitamura
Annual Report of Shionogi Research Laboratory, (43), 1 - 15, 1993
Lead - ACTIVATION OF GROUP-II PHOSPHOLIPASE-A2 GENE VIA 2 DISTINCT MECHANISMS IN RAT VASCULAR SMOOTH-MUSCLE CELLS
H ARITA; T NAKANO; O OHARA; H TERAOKA
ADVANCES IN PROSTAGLANDIN THROMBOXANE AND LEUKOTRIENE RESEARCH, 21, 277 - 280, 1991, Not invited
Lead - ADA-SCID with 'WAZA-ARI' mutations that synergistically abolished ADA protein stability
Yuka Okura; Masafumi Yamada; Ichiro Kobayashi; Ines Santisteban; Gabriella Arredondo-Santisteban; Zenichiro Kato; Akihiro Iguchi; Makoto Yoshida; Osamu Ohara; Noriko Nakagawa; Kohsuke Imai; Michael S. Hershfield; Tadashi Ariga
British Journal of Haematology, 153, 675 - 676, 1978, Not invited
Lead
Books and other publications
- 外来で見つける先天代謝異常症
小原 收, Contributor
中山書店, Feb. 2023
ISBN:9784521749242ヒトマイクロバイオーム
川島裕介、小原收、須田亙, Contributor
NTS(エヌ・ティー・エス), Jun. 2020
ISBN:9784860436599バイオ高性能機器・新技術利用マニュアル
小原 收, Joint editor
共立出版, Aug. 2004
ISBN:4320056264Lectures, oral presentations, etc.
- Establishment of a diagnosis system for somatic mosaicism in autoinflammation: From research to genetic testing
Osamu Ohara
APSID-JSIAD 2024, Mar. 2024, InvitedPCRアンプリコンによるロングリードシーケンシング：様変わりしつつあるロングPCR
小原 收
東洋紡xオックスフォード・ナノポアテクノロジーズ共催ウェビナー, Mar. 2024, Invited次世代シーケンシング（NGS)と難病の遺伝学的検査
小原 收
イルミナユーザーグループミーティング, Jan. 2024, Invitedプロテオゲノミクス研究の現状と将来展望
小原 收
第73回日本電気泳動学会シンポジウム, Dec. 2023, Invited何のための「オミックス解析」？：その必要性と今後の展望
小原 收
第46回日本分子生物学会年会ランチオンセミナー, Dec. 2023, InvitedNext generation sequencing first? Challenging traditional diagnostic pathways
Osamu Ohara
4th Asia Pacific course: Early diagnosis and early treatment of inherited metabolic diseases, Nov. 2023, Invited次世代新生児スクリーニングに向けた胎動：次世代シーケンシングを越えて
小原 收
第50回日本マススクリーニング学会学術集会、50周年記念レクチャー, Aug. 2023, Invited登録衛生検査所における難病領域の遺伝学的検査の現状と課題
小原 收
第30回日本遺伝子診療学会大会, Jul. 2023, Invited免疫不全症の遺伝学的検査：現状と今後の展開
小原 收
第12回関西免疫不全症研究会, Jul. 2023, Invited遺伝学的検査の厳密性とあいまいさ
小原 收
第47回日本遺伝カウンセリング学会学術集会, Jul. 2023, Invited遺伝学的検査の受託機関から見た今後の課題
小原 收
第65回日本小児神経学会学術集会, May 2023, Invitedオミックス計測で迫る⾃⼰炎症性疾患：免疫細胞社会の秩序とその破綻
小原 收
第12回東日本小児リウマチ研究会, May 2023, Invited原発性免疫不全症の遺伝学的検査の現状と今後
小原 收
広島免疫不全症セミナー, Apr. 2023, InvitedCurrent Status and Limitations of Genetic Testing for Intractable Diseases: Expectations for Proteomics
Osamu Ohara
Non-target proteomics and clinical diagnosis, Mar. 2023, Invited遺伝性希少疾患の遺伝学的検査ー有用性とその限界ー
小原 收
腎疾患に潜む希少疾患セミナー ーファブリー病ー, Feb. 2023, Invitedオミックス時代の新生児スクリーニング：計測技術的な観点から
小原 收
第45回日本小児遺伝学会学術集会, Jan. 2023, InvitedDNAシーケンシング技術の過去と現在、そして未来
小原 收
第67回日本人類遺伝学会 共催セミナー, Dec. 2022, Invitedオミックス解析のコアとしてのプロテオーム解析：最新の話題と今後の臨床診断応用
小原 收
久留米医学部小児科 Grand Rounds, Oct. 2022, Invited希少難病の「研究」から「検査」へ：かずさDNA研究所の取り組み
小原 收
かずさDNA研究所開所記念講演会, Oct. 2022, Invitedマルチオミックスの中心でプロテオミクスを叫ぼう！
小原 收
日本プロテオーム学会 2022年大会, Aug. 2022, Invited遺伝子構造解析とオミックス解析：臨床応用のための統合化に向けた取り組みの現状と展望
小原 收
第40回日本骨代謝学会, Jul. 2022, Invited登録衛生検査所における希少難病の遺伝学的検査の現状
小原 收
2022 IRUDワークショップ, Jul. 2022, Invited遺伝学的検査、どれを選ぶ？
小原 收
第18回日本先天代謝異常学会セミナー, Jul. 2022, Invited保険適用が拡大する指定難病等の遺伝学的検査への対応と検査精度の保証体制
小原 收
第29回日本遺伝子診療学会, Jul. 2022, Invited希少難病の遺伝学的検査：現状と今後の課題
小原 收
M3イルミナ主催教育ウェブセミナー, Jun. 2022, Invited脊髄性筋萎縮症スクリーニングの現状と課題ー計測技術の観点からー
小原 收
Medical Symposium 脊髄性筋萎縮症診療の現状と未来, Dec. 2021, InvitedハイスループットDNA合成により駆動されるマルチオミックス解析
小原 收
第４４回日本分子生物学会年会 バイオテクノロジーセミナー, Dec. 2021, Invitedゲノミクスを活用した遺伝子関連検査の精度管理と精度保証：計測技術的な観点から
小原 收
第６１回日本臨床化学年会年次学術集会, Nov. 2021オミックス解析の診断への応用可能性：最近の進歩
小原 收
久留米大学医学小児科 Ground Rounds, Oct. 2021, Invitedオミックス時代の新生児スクリーニングへの展望
小原 收
第４８回日本マススクリーニング学会学術集会, Sep. 2021, Invited希少難病の遺伝学的検査の現状と課題：検査と研究の間で
小原 收
第１８回広島臨床遺伝セミナー, Aug. 2021, Invitedマルチオミックス解析の現状と今後の展開：臨床研究から検査へ
小原 收
東大腎臓内分泌カンファレンス, Jul. 2021, Invited希少難病の遺伝学的検査の現状と課題遺伝医療と検体検査：現状と課題
小原 收
第４５回日本遺伝カウンセリング学会学術集会, Jul. 2021, Invitedオミックス解析の現状とその応用：臓器レベルから1細胞レベルまで
小原 收
第１６回山梨医学フォーラム, Jun. 2021, Invited希少疾患の遺伝子診断：乾燥ろ紙血を用いた解析技術の進歩
小原 收
第８回ムコ多糖症フォーラム2021, Jun. 2021, Invitedマルチオミックス解析におけるプロテオミクスの重要性
川島 祐介; 小原 收
Mar. 2021小児科診療における遺伝子診断の実際
小原 收
第３４回近畿小児科学会, Feb. 2021, Invited難病の遺伝学的検査実績とNGS検査の精度管理
小原 收
「難病医療における遺伝学的検査の現状と課題」オンラインシンポジウム, Feb. 2021, Invited希少難病の遺伝学的検査の現状と課題
小原 收
日本遺伝子診療学会 遺伝子診断・検査技術推進フォーラム 公開シンポジウム2020, Jan. 2021, Invited短鎖リード型NGSデータを補完するための臨床オミックス解析の遺伝学的検査への応用
小原 收
第４３回日本小児遺伝学会学術集会, Jan. 2021, Invited希少難病のクリニカルシーケンシングによる遺伝学的検査の現状と課題
小原收; 堤正好
第40回医療情報学連合大会, Nov. 2020, Invitedマルチオミックス解析の現状と臨床応用への課題
川島 祐介、小原 收
第71回日本電気泳動学会, Nov. 2020, Invited先端ゲノミクス計測の臨床検査への応用可能性と課題
小原 收
第32回日本臨床検査医学会関東信越支部総会, Sep. 2020, Invited保険収載された希少難病の遺伝子検査の現状
小原 收
第27回日本遺伝子診療学会, Sep. 2020, Invited新生児スクリーニングのためのオミックス計測技術の最近の進歩
小原 收
第123回日本小児科学会学術集会, Aug. 2020, Invited希少難病の遺伝学的検査の提供体制：研究と検査の間で
小原 收
第62回日本小児神経学会学術集会, Aug. 2020, Invited遺伝性免疫疾患研究における細胞社会のオミックス解析
小原 收
第41回日本炎症・再生医学会, Jul. 2020, Invitedゲノム科学からの免疫不全症研究への挑戦：「検査」と「研究」の間で
小原收
第10回Q-PID九州地区免疫不全症研究会, Nov. 2019細胞社会の秩序とアレルギー：オミックス計測からのアプローチ
小原收
第56回日本小児アレルギー学会学術大会, Nov. 2019オミックス検査学の潮流：ゲノムファーストからオミックスファーストへ
小原收
第66回日本臨床検査医学会学術集会, Nov. 2019ゲノム科学を医科学研究・臨床に活用していただくために：クリニカルシーケンシングから臨床オミックス研究まで
小原收
第１回がんゲノム研究会（富山大学医学部）, Aug. 2019ゲノムは私達の未来をどこまで予測できるのか？
小原收
ノバルディスファーマメディカル本部カンファレンス, Aug. 2019ゲノムファーストからオミックスファーストへ：ゲノム科学はこれからどこに向かうのか？
小原收
質量分析フォーラム2019, Jul. 2019Research Themes
- 特定の病原体に対する易感染性に着眼した原発性免疫不全症の病因病態解明
科学研究費補助金, 日本学術振興会, 基盤研究(B)
Apr. 2019 - Mar. 2022 - 発症予防に向けた動脈疾患の病因解明と病態の理解
科学研究費補助金, 日本学術振興会, 基盤研究(C)
Apr. 2019 - Mar. 2022 - マルチオミックス解析を用いた原発性免疫不全症の病因病態解析
科学研究費補助金, 日本学術振興会, 国際共同研究加速基金(国際共同研究強化(B))
Oct. 2018 - Mar. 2021 - EBウイルス陽性胃癌のTETを介した網羅的エピゲノム変化の解明
科学研究費補助金, 日本学術振興会, 研究活動スタート支援
Aug. 2017 - Mar. 2019 - 包括的アプローチによる慢性皮膚粘膜カンジダ症の分子病態の解明と治療標的の探索
科学研究費補助金, 日本学術振興会, 基盤研究(B)
Apr. 2016 - Mar. 2019 - 蛍光・発光蛋白質会合センサーを用いたNLRP3インフラマソーム活性化機構の解明
科学研究費補助金, 日本学術振興会, 挑戦的萌芽研究
Apr. 2016 - Mar. 2019 - EBV陽性T/NK細胞リンパ腫におけるAPOBECの機能
科学研究費補助金, 日本学術振興会, 基盤研究(C)
Apr. 2015 - Mar. 2018 - Neoantigensをターゲットにした肺がん個別化がんワクチン治療の開発
科学研究費補助金, 日本学術振興会, 基盤研究(B)
Apr. 2015 - Mar. 2018 - 難治性炎症病態を示す免疫異常症の原因遺伝子探索及び病態解明のための基盤構築
科学研究費補助金, 日本学術振興会, 基盤研究(B)
Apr. 2015 - Mar. 2018 - 遺伝性リンパ増殖症の新たな診断法の開発と病態解析
科学研究費補助金, 日本学術振興会, 基盤研究(C)
Apr. 2014 - Mar. 2017 - 自己炎症性疾患の分子病態解明に基づく最適医療基盤技術の創出
科学研究費補助金, 日本学術振興会, 基盤研究(A)
Apr. 2014 - Mar. 2017 - 分子病態に基づく血球貪食性リンパ組織球症の新規診療基盤開発
科学研究費補助金, 日本学術振興会, 基盤研究(C)
Apr. 2014 - Mar. 2017 - 免疫不全症・免疫異常症を背景とする血球減少症の分子基盤の解明
科学研究費補助金, 日本学術振興会, 基盤研究(B)
Apr. 2014 - Mar. 2017 - FLNA異常症の病態解析、診療基盤の確立、および特異的治療法の開発
科学研究費補助金, 日本学術振興会, 若手研究(B)
Apr. 2014 - Mar. 2016 - 寒冷誘発炎症を主症状とするメンデル遺伝疾患を利用した寒冷誘発遺伝子発現の機序解明
科学研究費補助金, 日本学術振興会, 挑戦的萌芽研究
Apr. 2013 - Mar. 2016 - 活性化T細胞運命決定の普遍的分子機構の解明
科学研究費補助金, 日本学術振興会, 挑戦的萌芽研究
Apr. 2013 - Mar. 2015 - 慢性皮膚粘膜カンジダ症の疾患モデルマウスの作成と治療法の確立
科学研究費補助金, 日本学術振興会, 挑戦的萌芽研究
Apr. 2013 - Mar. 2015 - 網羅的遺伝子解析及び細胞工学的手法を用いた不明発熱症候群の原因解明
科学研究費補助金, 日本学術振興会, 基盤研究(B)
Apr. 2012 - Mar. 2015 - 細胞生物学および分子生物学的手法を用いた肉芽腫形成の分子メカニズム解明
科学研究費補助金, 日本学術振興会, 基盤研究(B)
Apr. 2011 - Mar. 2014 - 自己炎症性疾患に対する新たな分子細胞生物学的手法を駆使した病態解明・治療基盤開発
科学研究費補助金, 日本学術振興会, 基盤研究(A)
Apr. 2011 - Mar. 2014 - 単一遺伝子異常による免疫学的寛容破綻の分子機構に関する研究
科学研究費補助金, 日本学術振興会, 基盤研究(B)
Apr. 2011 - Mar. 2014 - 悪性黒色腫の単一細胞解析によるがん多様性の研究
科学研究費補助金, 日本学術振興会, 挑戦的萌芽研究
2011 - 2012 - KREC/TRECによる先天性免疫不全症スクリーニング法開発と病態解析への応用
科学研究費補助金, 日本学術振興会, 基盤研究(B)
2010 - 2012 - 急性骨髄性白血病幹細胞特異的なスプライシングの包括的解析と診断・治療の基盤整備
科学研究費補助金, 日本学術振興会, 若手研究(B)
2009 - 2011 - 細胞工学的手法によるCINCA症候群の病態の解明それに基づく治療法の開発
科学研究費補助金, 日本学術振興会, 基盤研究(B)
2009 - 2011 - 遺伝子制御ネットワークの動的挙動の解明:制御論的理論解析と実験による検証
科学研究費補助金, 日本学術振興会, 挑戦的萌芽研究
2009 - 2010 - 重症複合免疫不全症の新生児マススクリーニング実現への簡易かつ低コスト測定法の開発
科学研究費補助金, 日本学術振興会, 若手研究(B)
2009 - 2010 - 記憶B細胞の形成・維持と細胞分化にかかわる分子機構
科学研究費補助金, 日本学術振興会, 特定領域研究
2004 - 2006 - ヒト脳内長鎖cDNA解析データベースを基盤としたマウス扁桃体の情動神経機構の解明
科学研究費補助金, 日本学術振興会, 萌芽研究
2001 - 2002 - 新しく発見した遺伝性ニューロフィラメント欠損ウズラの神経疾患モデル動物化
科学研究費補助金, 日本学術振興会, 試験研究(B)
1992 - 1994
