Connective tissue disease and allergy, Allergology

Nutrition science and health science, Food Assistance in Disasters

2023
Faculty of Education, Shinshu University, Associate professor

2007 - 2023
Faculty of Human Health Science, Matsumoto University, Lecturer

2000 - 2007
Applied Byosystems Japan Ltd., Field application specialist

1999 - 2000
Faculty of Medicine, Tokushima University, Research associate

1994, Tokushima Bunri University, Faculty of Home Economics, Department of home economics

1996, Graduate school of Tokushima University, Nutrition

1999, Graduate school of Tokushima University, Nutrition

Measurement results of Mal d 1 protein in apples cultivated in Nagano prefecture, Japan
N. Okishima, K. Kawai, K. Kobayashi, K. Tsuruta
Jpn. J. Food Chem. Safety, 30, 1-8, Apr. 2023, Refereed
Lead, Corresponding

Clinical Study of Pollen-food Allergy Syndrome Estimated by Double-blind, Placebo-controlled Food Challenges of Ten Apple Cultivars
Y.Koike, N.Okishima, M.Tokunaga, K.Kobayashi, Y.Inaba
The Shinshu Medical Journal, 71, 99-107, Apr. 2023, Refereed
Corresponding

Comprehensive analysis of Mal d 1 mRNA in apples cultivated in Japan
N.Okishima, M.Kawakami, M.Tamura, M.Niwano, C.Suzuki, T.Fukuda, S.Nakayama, M.Nitta
Jpn. J. Food Chem. Safety, 29, 12-18, Mar. 2022, Refereed
Lead, Corresponding

Monitoring results for the RRS, RRS2 and LLS from Kinugoshi tofu, Momen tofu, Yaki tofu and Kanten tofu distributed in the Matsumoto-City area
N.Okishima, Y.Takimoto, H.Takeuchi, M.Fukutomi, S.Yasunaga
日本食品化学学会誌, 26, 42-50, May 2019, Refereed
Lead, Corresponding

Correlations of Fat Intake, Obesity, Plasma Concentration of GLP-1, and Fatty Acid Receptor in Japanese
N.Okishima
松本大学研究紀要, 16, 83-90, Mar. 2018, Refereed
Lead, Last, Corresponding

Monitoring results for the RRS, RRS2 and LLS from processed soy product distributed at Matsumoto-city and its suburbs
N.Okishima, A.Kobayashi, M,Tokutake, F.Miyake, A.Murayama, K.Miyashita
日本食品化学学会誌, 22, 123-132, Aug. 2015, Refereed
Lead, Corresponding

管理栄養士養成課程の導入教育における早期体験学習の実践
Y.Fujioka, N.Okishima, N.Mizuno, M.Nakajima
栄養学雑誌, 71, 330-340, Nov. 2013, Refereed

Monitoring results for the RRS in soybean curds distributed at Matsumoto-city and its suburbs
N.Okishima, H.Uchiyama, T.Yanagisawa
日本食品化学学会誌, 20, 124-128, Aug. 2013, Refereed
Lead, Corresponding

Determination of the levels of novel 31-amino acid endothelins in human lung
N.Okishima, M.Yoshizumi, K.Tsuchiya, P.Cui, H.Kitamura, T.Tamaki, H.Kido
Life Sci., 68, 2073-2080, Oct. 2001, Refereed
Lead

Effect of endothelin-1(1-31) on intracellular free calcium in cultured human mesangial cells.
H.Yasuoka, M.Yoshizumi, D.Inui, N.Okishima, H.Houchi, K.Kirima, S.Oshita, H.Kido, T.Tamaki
Life Sci., 65, 267-272, Oct. 1999, Refereed

Mechanism of Endothelin-1-(1-31) -induced calcium signaling in human coronary artery smooth muscle cells
D.Inui, M.Yoshizumi, N.Okishima, H.Houchi, K.Tsuchiya, H.Kido, T.Tamaki
Am.J.Physiol., 276, E1067-E1072, Jun. 1999, Refereed

Specific sandwich-type enzyme immunoassays for smooth muscle constricting novel 31-amino-acid endothelins
N.Okishima, Y.Hagiwara, T.Seito, M.Yano, H.Kido
Biochem.Biophys.Res.Commun., 256, 1-5, Mar. 1999, Refereed
Lead

Human Chymase, an enzyme forming novel bioactive 31-amino acid length endothelins
H.Kido, A.Nakano, N.Okishima, H.Wakabayashi, F.Kishi, Y.Nakaya, M.Yoshizumi, T.Tamaki
Biol.Chem., 379, 885-891, Jul. 1998, Refereed

Novel 31-amino-acid length endothelins cause constriction of vascular smooth muscle
F.Kishi, K.Minami, N.OkishimaM.Murakami, S.Mori, M.Yano, Y.Niwa, Y.Nakaya, H.Kiso
Biochem.Biophys.Res.Commun., 248, 387-390, Jul. 1998, Refereed

Endothelin-1-(1-31), a novel vasoactive peptide, increases [Ca2+]i in human coronary artery smooth muscle cells
M.Yoshizumi, D.Inui, N.Okishima, H.Houchi, K.Tsuchiya, H.Wakabayashi, H.Kido, T.Tamaki
Eur.J.Phrmacol., 348, 305-309, May 1998, Refereed

Vitamin E supplementation normalizes immune dysfunction in murine aids induced by LP-BM5 retrovirus infection
N.Okishima, K.Hirata, S.Moriguchi, Y.Kishino
Nutr.Res., 16, 1709-1720, Oct. 1996, Refereed
Lead

Beta-carotene supplementation enhances lymphocyte proliferation with mitogens in human peripheral lymphocytes
S.Moriguchi, N.Okishima, S Sumida, K.Okamura, T.Doi, Y.Kishino
Nutr.Res., 16, 211-218, Feb. 1996, Refereed

栄養科学シリーズNEXT　分子栄養学
Joint work, 1.生物の多様性と進化
講談社サイエンティフィク, 10-18 Mar. 2018

保育者養成シリーズ　子どもの食と栄養
Joint work, 第3章　食物成分
一藝社, 37-50 Apr. 2017

Search for hypoallergenic apples by Mal d 1 determination and oral challenge tes
N.Okishima, K.Kobayashi, Y.Koike, Y.Kondo
WAO Symposium food and respratory allergies, May 2023

Double- blind, placebo-controlled food challenges with apple in pollen-food allergy syndrome patients
Y.Koike, M.Tokunaga, K.Kobayashi, N.Okishima
JSA/WAO Joint Congress 2020, Sep. 2020

The pack cooking helps food allergic patients at the time of disaster, focused on weaning foods
N.Okishima, S.Ogura, K.Nishimaki
JSA/WAO Joint Congress 2020, Sep. 2020

The distribution of Mal d 1 protein, apple allergen component, in apples cultivated and consumed in Japan
N.Okishima, C.Suzuki, T.Fukuda
JSA/WAO Joint Congress 2020, Sep. 2020

An Analysis of Allergen Contamination of Non-Allergen Food Preparation in an Home Setting
N.Okishima, M.Aoyama, M.Ogura
Asian Congress of Nutrition 2015, Sep. 2015

Results of monitoring for the glyphosate tolerance gene in soybean curds distributed at Matsumoto-city
N. Okishima
IUNS 20th International Congress of Nutrition, Sep. 2013

Novel Bioactive 31-Amino Acid Length Endothelins Formed by Human Chymase
N. Okishima. A. Nakano, Y. Hagiwara
May 1999

A Role of Chymase in Formation of Endothelin-1(1-31) in Dog Heart Homogenate
K. Kamoshita, K. lshida, K. Masuda
May 1999

Mechanism of endothelin-1(1-31)-induced calcium signaling in human coronary artery smooth muscle cells
D. Inui, M. Yoshizumi, N. Okishima
May 1999

Vitamin E supplementation normalizes immune dysfunction in murine aids induced by LP-BM5 retrovirus infection.
N.Okishima, S.Moriguchi, Y.Kishino
7th Asian Congress of Nutrition, Oct. 1995

Training exercise incleases function of alveolar macrophages in rats.
N.Okishima, S.Moriguchi, Y.Kishino
5th International Course and Conference on Physiological Chemistry and Nutrition of Exercise and Training, Oct. 1995

リンゴアレルゲンコンポーネントMal d 1の定量・経時変化と果皮の有無による比較
沖嶋直子、小林寧巴、清水亜弥
第24回食物アレルギー研究会, 食物アレルギー研究会, Not invited

Determination of apple PFAS allergen component Mal d 1

Application of Packed Cooking as Support for Patients with Food Allergies in Disasters

Evaluation of hypoallergenic apples by oral challenge test