Metabolism and endocrinology, Metabolomics

Tertiary education, Endocrinology

Metabolism and endocrinology, Metabolomics

Clinical Characteristics and Diagnostic Pitfalls of Pheochromocytoma: A Pathology-Confirmed Retrospective Study From a Single Japanese Center
Sekido T, Takayama S, Shibata Y, Sagesaka H, Shimada Y, Kubota S, Karasawa T, Kawai Y, Yamazaki M, Komatsu M.
Cureus, 18(5), e108629, May 2026

Safety of anagliptin/metformin combination tablets evaluated by non-inferiority between pre- and post-serum lactic acid levels in Japanese patients with type 2 diabetes and moderate renal impairment (AMELIO STUDY)
Kajio H, Bouchi R, Komatsu M, Yamazaki Y, Takarabe D, Okamoto M, Tanaka T, Kitazawa T, Katsuyama H, Mori Y, Noda M.
J Diabetes Investig, 17(4), 636-648, Apr. 2026

Novel germline likely pathogenic frameshift variant of the MEN1 gene contributes to multiple endocrine neoplasia type 1: a case report with review of literature
Yamazaki Y, Kojima K, Shibata Y, Kosho T, Komatsu M.
Endocr J, 72(11), 1255-1262, Nov. 2025
Lead, Corresponding

Interval walking training as a potential contributor to motor function improvement in adults with type 2 diabetes mellitus: a retrospective analysis
Yamazaki M, Hosokawa M, Kitajima K, Komatsu M.
Front Endocrinol (Lausanne), 16, 1544831, Jul. 2025
Lead, Corresponding

Within- and Between-Individual Variations in Protein, Sodium, Potassium, and Phosphorus Intake Estimated from Urinary Biomarkers and Dietary Records in Individuals with Type 2 Diabetes Mellitus
Takaoka T, Watanabe D, Hosokawa M, Hosokawa K, Kubota S, Kawai Y, Oono F, Inoue Y, Zakoji C, Oiwa A, Sato A, Yamazaki M, Komatsu M.
Nutrients, 17(11), 1757, May 2025

An ACTH-Producing Neuroendocrine Tumor: Clinical Course of Multidisciplinary Therapy Including Peptide Receptor Radionuclide Therapy - A Case Report
Koizumi T, Sato A, Kitajima K, Yamazaki M, Kanazawa S, Notake T, Sato Y, Kobayashi S, Iwaya M, Umeda T, Komatsu M.
Case Rep Oncol, 18(1), 181-189, Jan. 2025

Improving glycemic control by transitioning from the MiniMedTM 640G to 770G in Japanese adults with type 1 diabetes mellitus: a prospective, single-center, observational study
Kubota S, Sato A, Hosokawa M, Okubo Y, Takayama S, Kaneko A, Shimada Y, Asano Y, Sato Y, Yamazaki M, Komatsu M.
Endocr J, 71(10), 955-963, Oct. 2024

Psychological impact and genetic counseling in patients with multiple endocrine neoplasia type 1(MEN1): addressing quality of life concerns
Miyazaki S,Suda K, Ito M, Yamazaki M, Uchino S, Sakurai A.
Sapporo Med J, 93(1-6), 65-78, Sep. 2024

A Case of Primary Aldosteronism Turned Out to Be Adrenocortical Carcinoma With Disorganized Steroidogenesi
Ohkubo Y, Shimada Y, Tanaka H, Yamazaki M, Komatsu M
Cureus, (1), e52137, Jan. 2024

Rare Coexistence of Aldosterone-producing Adrenocortical Adenoma Confirmed by an Immunohistochemical Analysis of Steroidogenic Enzymes with Adrenal Ectopic Thyroid Tissue: A Case Report and Literature Review
Ohkubo Y, Yamazaki M, Shimada Y, Kubota S, Takayama S, Oiwa A, Yamazaki Y, Sasano H, Komatsu M.
Intern Med, 63(2), 259-264, Jan. 2024
Corresponding

【糖尿病と認知症】薬物治療と認知症　その他の糖尿病治療薬と認知症
山崎雅則
Progress in Medicine, 43(12), 1125-1130, Dec. 2023
Lead

Future Medical Care for Older Adults with Diabetes : A Clinical Approach Based on the Practice Guideline for the Treatment of Elderly Diabetes in Japan 2023
YAMAZAKI, Masanori
The Shinshu Medical Journal, 71(5), 249-256, Oct. 2023

Efficacy and safety of low-dose spironolactone for chronic kidney disease in type 2 diabetes
Oiwa A, Hiwatashi D, Takeda T,　Miyamoto T, Kawada I, Koinuma M, Yamazaki M, Komatsu M
J Clin Endocrinol Metab, 108, 2203-2210, Aug. 2023

Hypertrophic Pachymeningitis Associated with Myeloperoxidase-anti-neutrophil Cytoplasmic Antibodies Induced by Propylthiouracil
Koide S, Kitajima K, Yamazaki M, i Ichikawa T, Komatsu M.
Intern Med, 62(13), 1951-1955, Jul. 2023
Corresponding

Interval walking training in type 2 diabetes: A pilot study to evaluate the applicability as exercise therapy
Kitajima K, Oiwa A, Miyakoshi T, Hosokawa M, Furihata M, Takahashi M, Masuki S, Nose H, Okubo Y, Sato A, Yamazaki M, Komatsu M.
PLoS One, 18(5), e0285762, May 2023

Extra-endocrine phenotypes at infancy in multiple endocrine neoplasia type 2B: A case series of six Japanese patients
Matsushita R, Sakurai A, Minamitani K, Yamazaki M, Uchino S
Clin Pediatr Endocrinol, 30(4), 195-200, 2021

Changes in serum uric acid levels as a predictor of future decline in renal function in older adults with type 2 diabetes
Shibata Y, Yamazaki Y, Kitahara J, Okubo Y, Oiwa A, Sato A, Komatsu M
Medicine (Baltimore), 100(40), e27420, 2021

JNETS clinical practice guidelines for gastroenteropancreatic neuroendocrine neoplasms: diagnosis, treatment, and follow-up: a synopsis
Ito T , Masui T , Komoto I , Doi R , Osamura RY, Sakurai A, Ikeda M, Takano K, Igarashi H, Shimatsu A, Nakamura K, Nakamoto Y, Hijioka S, Morita K, Ishikawa Y, Ohike N, Kasajima A, Kushima R, Kojima M, Sasano H, Hirano S, Mizuno N, Aoki T, Aoki T, Ohtsuka T, Okumura T, Kimura Y, Kudo A, Konishi T, Matsumoto I, Kobayashi N, Fujimori N, Honma Y, Morizane C, Uchino S, Horiuchi K, Yamasaki M, Matsubayashi J, Sato Y, Sekiguchi M, Abe S, Okusaka T, Kida M, Kimura W, Tanaka M, Majima Y, Jensen RT, Hirata K, Imamura M, Uemoto S
J Gastroenterol, 56, 1033-1044, 2021

Aldosterone to Potassium Ratio after Adrenocorticotropin Stimulation in Unilateral Primary Aldosteronism Diagnosis
Kitahara, Junichiro; Ohkubo, Yousuke; Kitajima, Kouhei; Nishio, Shin-ichi; Oiwa, Ako; Sato, Ai; Yamazaki, Masanori; Sakuma, Takahiro; Sano, Asami; Nishii, Yutaka; Komatsu, Mitsuhisa
The Shinshu Medical Journal, 68(3), 159-168, 10 Jun. 2020

Implications of thyroid autoimmunity in infertile women with subclinical hypothyroidism in the absence of both goiter and anti-thyroid antibodies: lessons from three cases.
Oiwa A, Minemura K, Nishio SI, Yamazaki M, Komatsu M
Endocr J, 66(2), 193-198, 2019

Effects of Sitagliptin on Pancreatic Beta-Cells in Type 2 Diabetes With Sulfonylurea Treatment: A Prospective Randomized Study
Sato A, Takei M, Hiramatsu K, Takeda T, Miyamoto T, Yamazaki M, Sato Y, Komatsu M
J Clin Med Res, 11(1), 15-20, 2019

Analysis for the Improvement of Inadequate Glycemic Control in Patients with Type 2 Diabetes Mellitus in Nagano, Japan
Sato A, Sato Y, Kobayashi Y, Yamazaki M, Komatsu M
信州医学雑誌, 66(5), 319-324, Oct. 2018

Prediction of lowest nocturnal blood glucose level based on self-monitoring of blood glucose in Japanese patients with type 2 diabetes
Sakurai K, Kawai Y, Yamazaki M, Komatsu M
J Diabetes Complications, 32(12), 1118-1123, 2018

Careful readings for a flash glucose monitoring system in nondiabetic Japanese subjects: individual differences and discrepancy in glucose concentrarion after glucose loading
Sekido K, Sekido T, Kaneko A, Hosokawa M, Sato A, Sato Y, Yamazaki M, Komatsu M
Endocr J, 64(8), 827-832, 2017

Early-onset, severe, and recurrent primary hyperparathyroidism associated with a novel CDC73 mutation.
Shibata Y, Yamazaki M, Takei M, Uchino S, Sakurai A, Komatsu M.
Endocr J, 62(7), 627-632, 2015

Occurrence of IgG4-related Hypophysitis Lacking IgG4-bearing Plasma Cell Infiltration during Steroid Therapy
Ohkubo Y, Sekido T, Takeshige K, Ishi H, Takei M, Nishio S, Yamazaki M, Komatsu M, Kawa S, Suzuki S.
Intern Med, 53, 753-757, 2014

Efficacy of Combination Therapy With Sitagliptin and Low-Dose Glimepiride in Japanese Patients With Type 2 Diabetes
Ishii H, Ohkubo Y, Takei M, Nishio S, Yamazaki M, Kumagai M, Sato Y, Suzuki S, Aoki Y, Miyamoto T, Kakizawa T, Sakuma T, Komatsu M
J Clin Med Res., 6, 127-132, 2014

A newly identified missense mutation in RET codon 666 is associated with the development of medullary thyroid carcinoma.
Yamazaki M, Hanamura T, Ito K, Uchino S, Sakurai A, Komatsu M
Endocr J, 61(11), 1141-1144, 2014

Thymic neuroendocrine tumour in multiple endocrine neoplasia type 1: female patients are not rare exceptions.
Sakurai A, Imai T, Kikumori T, Horiuchi K, Okamoto T, Uchino S, Kosugi S, Suzuki S, Suyama K, Yamazaki M, Sato A; MEN Consortium of Japan.
Clin Endocrinol (Oxf)., 78(2), 248-54, 2013

A Novel splice site mutation of the MEN1 gene indentified in a patient with primary hyperparathyroidism
Nagamura Y, Yamazaki M, Shimazu S, Sano K, Tsukada T, Sakurai A.
Endocr J, 59, 523-530, 2012

Clinical features of insulinoma in patients with multiple endocrine neoplasia type 1: analysis of the database of the MEN Consortium ofJapan.
Sakurai A, Yamazaki M, Suzuki S, Fukushima T, Imai T, Kikumori T, Okamoto T, Horiuchi K, Uchino S, Kosugi S, Yamada M, Komoto I, Hanazaki K, Itoh M, Kondo T, Mihara M, Imamura M.
Encocr J, 59, 859-866, 2012

Delay in the diagnosis of multiple endocrine neoplasia type 1: typical symptoms are frequently overlooked
Yamazaki M, Suzuki S, Kosugi S, Okamoto T, Uchino S, Miya A, Imai T, Kaji H, Komoto I, Miura D, Yamada M, Uruno T, Horiuchi K, Sato A, Miyauchi A, Imamura M, Sakurai A; MEN Consortium of Japan
Endocr J, 59, 797-807, 2012

Multiple endocrine neoplasia type 1 in Japan: establishment and analysis of a multicentre database
Sakurai A, Suzuki S, Kosugi S, Okamoto T, Uchino S, Miya A, Imai T, Kaji H, Komoto I, Miura D, Yamada M, Uruno T, Horiuchi K, Miyauchi A, Imamura M; MEN Consortium of Japan, Fukushima T, Hanazaki K, Hirakawa S, Igarashi T, Iwatani T, Kammori M, Katabami T, Katai M, Kikumori T, Kiribayashi K, Koizumi S, Midorikawa S, Miyabe R, Munekage T, Ozawa A, Shimizu K, Sugitani I, Takeyama H, Yamazaki M.
Clin Endocrinol (Oxf), 76, 533-539, 2012

Application of an intracellular stability test of a novel missense menin mutant to the diagnosis of multiple endocrine neoplasia type 1
Nagamura Y, Yamazaki M, Shimazu S, Tsukada T, Sakurai A.
Endocr J, 59, 1093-1098, 2012

糖尿病の家族歴が患者の疾患認識に及ぼす影響について　糖尿病と遺伝の関係に関する患者の意識調査から
羽深 美恵子, 櫻井 晃洋, 山崎 雅則, 駒津 光久, 江口 尚, 野見山 哲生, 福嶋 義光
糖尿病, 55, 185-192, 2012

MEN1遺伝子に同定された塩基置換　変異か多型か?
櫻井 晃洋, 永村 優央子, 山崎 雅則, 島津 智子, 佐野 健司, 塚田 俊彦
日本内分泌学会雑誌, 88 supple, 90-94, 2012

糖尿病の家族歴が患者の疾患認識に及ぼす影響について : 糖尿病と遺伝の関係に関する患者の意識調査から
羽深 美恵子,櫻井 晃洋,山崎 雅則,駒津 光久,江口 尚,野見山 哲生,福嶋 義光
糖尿病, 55(3), 185-192, 2012

高齢者糖尿病治療の最前線】 Seminar　高齢者におけるGLP-1受容体作動薬の使い方
山崎 雅則, 駒津 光久
Geriatric Medicine, 40, 879-882, 2011

Cold-induced sweating syndrome with neonatal features of Crisponi syndrome: longitudinal observation of a patient homozygous for a CRLF1 mutation.
Yamazaki M, Kosho T, Kawachi S, Mikoshiba M, Takahashi J, Sano R, Oka K, Yoshida K, Watanabe T, Kato H, Komatsu M, Kawamura R,Wakui K, Knappskog PM, Boman H, Fukushima Y
Am J Med Genet, A 152A, 764-769, 2010

Distinct clinical courses in type 1 diabetes mellitus induced by peg-interferon-alpha treatment for chronic hepatitis C.
Yamazaki M, Sato A, Takeda T, Komatsu M.
Intern Med., 49(5), 403-7, 2010

Distinct Clinical Courses in Type 1 Diabetes Mellitus Induced by Peg-interferon-alpha Treatment for Chronic Hepatitis C
Yamazaki, Masanori; Sato, Ai; Takeda, Teiji; Komatsu, Mitsuhisa
INTERNAL MEDICINE, 49(5), 403-407, 2010

Transient polyuria related to central diabetes insipidus caused by lymphocytic infundibulo-neuro-hypophysitis in a patient treated for Graves' disease.
Yamazaki M, Sato A, Nishio S, Uehara T, Komatsu M
Intern Med, 49(17), 1885-1890, 2010

Five cases of severe hyponatremia in the elderly successfully treated with low doses of hydrocortisone.
Takei M, Suzuki S, Sato A, Yamazaki M, Shi S, Sato Y, Hashizume K
Geriatr Gerontol Int, 9, 391-394, 2009

Acromegaly accompanied by Turner syndrome with 47,XXX/45,X/46,XX mosaicism
Yamazaki M, Sato A, Nishio S, Takeda T, Miyamoto T, Katai M, Hashizume K
Intern Med, 48(6), 447-453, 2009

Spiking Expression of mu-Crystallin mRNA during Treatment with Methimazole in Patients with Graves'Hyperthyroidism
Suzuki, S.; Takei, M.; Nishio, S.; Inaba, H.; Sato, A.; Yamazaki, M.; Shinomiya, K.; Hashizume, K.
HORMONE AND METABOLIC RESEARCH, 41(7), 548-553, 2009

Biphasic function of focal adhesion kinase in endothelial tube formation induced by fibril-forming collagens
Nakamura J, Shigematsu S, Yamauchi K, Takeda T, Yamazaki M, Kakizawa T, Hashizume K
Biochem Biophys Res Commun, 374, 699-703, 2008

内分泌環境と抗加齢医学
橋爪 潔志,鈴木 悟,稲垣 毅,宮本 高秀,平松 邦英,小松 亜位,大岩 亜子,山崎 雅則,西尾 真一,稲葉 秀文,森 淳一郎,柿沢 供子,武田 貞二,重松 理
日本老年医学会雑誌, 45(2), 145-148, 2008

Beneficial effects of pioglitazone on cholangiohepatitis induced by bile duct carcinoma.
Suzuki S, Mori J, Yamazaki M, Sato A, Hosoda W, Hashizume K
Intern Med, 46, 1723-1727, 2007

Adenovirus-mediated tumor-specificcombined gene therapy using herpes simplex virus thymidine/ganciclovir system and murine interleukin-12 induces effective antitumor activity against medullary thyroid carcinoma.
Yamazaki M, Straus FH, Messina M, Robinson BG, Takeda T, Hashizume K, DeGroot LJ
Cancer Gene Ther, 11, 8-15, 2004

アデノウイルスによるインターロイキン12の腫瘍特異的発現を利用した甲状腺髄様癌に対する免疫遺伝子治療
山崎 雅則,武田 貞二,橋爪 潔志
ホルモンと臨牀, 52(3), 271-277, 2004

Multiple endocrine neoplasia type 1 with unusual concomitance of various neoplastic disorders
Nishimura, Y; Yamashita, K; Yumita, W; Yamazaki, M; Katai, M; Sakurai, A; Hashizume, K
Endocrine journal, 51(1), 75-81, 2004

Tumor-specific gene therapy for undifferentiated thyroid carcinoma utilizing the telomerase reverse transcriptase promotor.
Takeda T, Inaba H, Yamazaki M, Kyo S, Miyamoto T, Suzuki S, Ehara T, Kakizawa T, Hara M, DeGroot LJ, Hashizume K
J Clin Endocrinol Metab, 88, 3531-3538, 2003

Effective gene therapy for medullary thyroid carcinoma using recombinant adenovirus inducing tumor-specific expression of interleukin-12.
Yamazaki M, Zhang R, Straus FH, Messina M, Robinson BG, Hashizume K, DeGroot LJ
Gene Ther, 9, 64-74, 2002

A tandemly repeated thyroblobulin core promoter has potential to enhance efficacy for tissue-specific gene therapy for thyroid carcinomas.
Takeda T, Yamazaki M, Minemura K, Imai Y, Inaba H, Suzuki S, Miyamoto T, Ichikawa K, Kakizawa T, Mori J, DeGroot LJ, Hashizume K
Cancer Gene Ther, 9, 864-874, 2002

Characterization of two novel retinoic acid-resistant cell lines derived from HL-60 cells following long-term culture with all-trans-retinoic acid
Mori, J; Suzuki, S; Hara, M; Kaneko, A; Yamashita, K; Kumagai, M; Sakuma, T; Kakizawa, T; Yamazaki, M; Takeda, T; Miyamoto, T; Ichikawa, K; Hashizume,K
JAPANESE JOURNAL OF CANCER RESEARCH, 90(6), 660-668, 1999

1,25-dihydroxyvitamin D-3 suppresses the expression of the VCAM-1 receptor, VLA-4 in human leukemic HL-60 cells
Kaneko, A; Suzuki, S; Hara, M; Mori, J; Kumagai, M; Yajima, H; Yamashita, K; Kakizawa, T; Yamazaki, M; Takeda, T; Miyamoto, T; Ichikawa, K; Hashizume, K
Biochemical and biophysical research communications, 255(2), 371-376, 1999

膵・消化管神経内分泌腫瘍（NEN）診療ガイドライン 2026年 【第3版】
日本神経内分泌腫瘍研究会（JNETS）
金原出版, Feb. 2026

内分泌代謝・糖尿病内科領域専門医研修ガイドブック
日本内分泌学会・日本糖尿病学会
診断と治療社, May 2023

高齢者糖尿病診療ガイドライン2023
一般社団法人日本老年医学会、一般社団法人日本糖尿病学会
南江堂, May 2023

遺伝性膵神経内分泌腫瘍の実践的診療　新ガイドラインを踏まえて
山崎雅則
第35回臨床内分泌代謝Update, Nov. 2025

高齢者糖尿病における経口血糖降下薬治療のポイントと注意点
山崎雅則
Jun. 2023

Progressive Albuminuria as a Key Factor Potentially Determining Cardiovascular Prognosis in the Elderly with Type 2 Diabetes: From a Three-Year Interim Report of a Cohort Study,Nagano Study 2
Yamazaki M, Shibata Y, Kawai Y, Komatsu M
77th Amerian Diabetes Association Scientific Session, 2019

Prediction of Lowest Nocturnal Blood Glucose (LNBG) Levels in Japanese Type 2 Diabetic (T2D) Patients Treated with Insulin
Kawai K, Yamazaki M, Sakurai K, komatsu K
77th Amerian Diabetes Association Scientific Session, 2017

Immunogene therapy of endocrine tumors

Epidemiology of multiple endocrine neoplasia

Epidemiology of type 2 diabetes