Nakada Tsutomu
Academic Assembly School of Medicine and Health Sciences Institute of Medicine
Research Center for Advanced Science and Technology
Associate Professor
Researcher Information
Research activity information
Paper
- Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart
Kawagishi, Hiroyuki; Nakada, Tsutomu; Numaga-Tomita, Takuro; Larranaga, Maite; Guo, Ang; Song, Long-Sheng; Yamada, Mitsuhiko;
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 323(1), H103-H120, Jul. 2022
- NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca2+ Homeostasis
Inazumi, Hideaki; Kuwahara, Koichiro; Nakagawa, Yasuaki; Kuwabara, Yoshihiro; Numaga-Tomita, Takuro; Kashihara, Toshihide; Nakada, Tsutomu; Kurebayashi, Nagomi; Oya, Miku; Nonaka, Miki; Sugihara, Masami; Kinoshita, Hideyuki; Moriuchi, Kenji; Yanagisawa, Hiromu; Nishikimi, Toshio; Motoki, Hirohiko; Yamada, Mitsuhiko; Morimoto, Sachio; Otsu, Kinya; Mortensen, Richard M.; Nakao, Kazuwa; Kimura, Takeshi;
Circulation Research, 130(2), 234-248, 2022 - Adrenomedullin-RAMP2 and -RAMP3 Systems Regulate Cardiac Homeostasis during Cardiovascular Stress
Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Tanaka M, Wei Y, Kakihara S, Zhao Y, Aruga K, Kawagishi H, Nakada T, Yamada M, Shindo T.
Endocrinology., 162(3), bqab001, Mar. 2021 - β-Arrestin-Biased AT 1 Agonist TRV027 Causes a Neonatal-Specific Sustained Positive Inotropic Effect Without Increasing Heart Rate
Kashihara T, Kawagishi H, Nakada T, Numaga-Tomita T, Kadota S, Wolf EE, Du CK, Shiba Y, Morimoto S, Yamada M.
JACC Basic Transl Sci., 5(11), 1057-1069, Nov. 2020 - Prostanoid EP4 Receptor-Mediated Augmentation of I-h Currents in A beta Dorsal Root Ganglion Neurons Underlies Neuropathic Pain
Zhang, Hao; Kashihara, Toshihide; Nakada, Tsutomu; Tanaka, Satoshi; Ishida, Kumiko; Fuseya, Satoshi; Kawagishi, Hiroyuki; Kiyosawa, Kenkichi; Kawamata, Mikito; Yamada, Mitsuhiko;
Journal of Pharmacology and Experimental Therapeutics, 368(1), 50-58, 2019 - Increase in phospholamban content in mouse skeletal muscle after denervation
Komatsu, Masatoshi; Nakada, Tsutomu; Kawagishi, Hiroyuki; Kato, Hiroyuki; Yamada, Mitsuhiko;
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 39(5-6), 163-173, Dec. 2018 - PDGF-induced migration of synthetic vascular smooth muscle cells through c-Src-activated L-type Ca2+ channels with full-length Ca(V)1.2 C-terminus
Guo, Xiaoguang; Kashihara, Toshihide; Nakada, Tsutomu; Aoyama, Toshifumi; Yamada, Mitsuhiko;
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 470(6), 909-921, Jun. 2018, Refereed - Physical interaction of junctophilin and the Ca(V)1.1 C terminus is crucial for skeletal muscle contraction
Nakada, Tsutomu; Kashihara, Toshihide; Komatsu, Masatoshi; Kojima, Katsuhiko; Takeshita, Toshikazu; Yamada, Mitsuhiko;
Proceedings of the National Academy of Sciences of the United States of America, 115(17), 4507-4512, Apr. 2018, Refereed - Angiotensin II activates Ca(V) 1.2 Ca(2+) channels through β-arrestin2 and casein kinase 2 in mouse immature cardiomyocytes.
Kashihara T, Nakada T, Kojima K, Takeshita T, Yamada M.
J Physiol, 595(13), 4207-4225, Jul. 2017, Refereed - Ammonia exposure affects the mRNA and protein expression levels of certain Rhesus glycoproteins in the gills of climbing perch
Chen, Xiu L.; Zhang, Biyan; Chng, You R.; Ong, Jasmine L. Y.; Chew, Shit F.; Wong, Wai P.; Lam, Siew H.; Nakada, Tsutomu; Ip, Yuen K.;
JOURNAL OF EXPERIMENTAL BIOLOGY, 220(16), 2916-2931, 2017, Refereed - マイクロRNAを標的とした核酸医薬による骨格筋サルコペニア予防・治療法の開発
中田勉
医科学応用研究財団研究報告, 33, 296-300, Feb. 2016 - β(2)-Adrenergic and M(2)-muscarinic receptors decrease basal t-tubular L-type Ca2+ channel activity and suppress ventricular contractility in heart failure
Kashihara, T; Hirose, M; Shimojo, H; Nakada, T; Gomi, S; Hongo, M; Yamada, M
European Journal of Pharmacology, 724, 122-131, Feb. 2014, Refereed
- 横紋筋L型カルシウムチャネルの結合膜局在化機構
中田勉，山田充彦
日本薬理学雑誌, 144, 217-221, 2014 - TRPM4 channels mediate hypertonicity-induced, Ca2+-impermeable, Non-selective cation currents in a cervical cancer cell line, HeLa cells
Gomi S, Nakada T, Kashihara T, Ikeda U, Yamada M
shinshu med J, 62, 33-44, 2014, Refereed - Phlorizin prevents electrically-induced ventricular tachyarrhythmia during ischemia in Langendorff-perfused guinea-pig hearts
Hirose M, Shibazaki T, Nakada T, Kashihara T, Yano S, Okamoto Y, Isaji M, Matsushita N, Taira E, Yamada M
Biol Pharm Bull, 37(7), 1168-1176, 2014, Refereed - Cardiac overexpression of constitutively active Gαq causes angiotensin II type1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice
Matsushita N, Kashihara T, Shimojo H, Suzuki S, Nakada T, Takeishi Y, Mende U, Taira E, Yamada M, Sanbe A, Hirose M
PLOS ONE, 9(8), e106354, 2014, Refereed - Expression of a novel isoform of Na(+)/H(+) exchanger 3 in the kidney and intestine of banded houndshark, Triakis scyllium.
Li S, Kato A, Takabe S, Chen AP, Romero MF, Umezawa T, Nakada T, Hyodo S, Hirose S
American journal of physiology. Regulatory, integrative and comparative physiology, 304(10), R865-76, May 2013, Refereed - Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system.
Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T
Hypertension (Dallas, Tex. : 1979), 61(2), 341-351, Feb. 2013, Refereed - The proximal C-terminus of alpha(1C) subunits is necessary for junctional membrane targeting of cardiac L-type calcium channels
Nakada, Tsutomu; Flucher, Bernhard E.; Kashihara, Toshihide; Sheng, Xiaona; Shibazaki, Toshihide; Horiuchi-Hirose, Miwa; Gomi, Simmon; Hirose, Masamichi; Yamada, Mitsuhiko
Biochemical Journal, 448(2), 221-231, Dec. 2012, Refereed - Two mechanistically distinct effects of dihydropyridine nifedipine on Ca(V)1.2 L-type Ca(2+) channels revealed by Timothy syndrome mutation
Xiaona Sheng, Tsutomu Nakada, Motohiro Kobayashi, Toshihide Kashihara, Toshihide Shibazaki, Miwa Horiuchi-Hirose, Simmon Gomi, Masamichi Hirose, Toshifumi Aoyama, and Mitsuhiko Yamada
Eur J Pharmacol, 685(1-3), 15-23, 15 Jun. 2012, Refereed - Expression of long-form N-acetylglucosamine-6-O-sulfotransferase 1 in human high endothelial venules
Maiko Fujiwara, Motohiro Kobayashi, Hitomi Hoshino, Kenji Uchimura, Tsutomu Nakada, Junya Masumoto, Yasuhiro Sakai, Minoru Fukuda, and Jun Nakayama
J Histochem Cytochem, 60(5), 397-407, 25 Apr. 2012, Refereed - Chronic receptor-mediated activation of Gi/o proteins alters basal t-tubular and sarcolemmal L-type Ca²⁺ channel activity through phosphatases in heart failure
Toshihide Kashihara, Tsutomu Nakada, Hisashi Shimojo, Miwa Horiuchi-Hirose, Simmon Gomi, Toshihide Shibazaki, Xiaona Sheng, Masamichi Hirose, Minoru Hongo, and Mitsuhiko Yamada
Am J Physiol Heart Circ Physiol, 302(8), H1645-1654, 15 Apr. 2012, Refereed - Nicorandil prevents Gαq-induced progressive heart failure and ventricular arrhythmias in transgenic mice.
Hirose M, Takeishi Y, Nakada T, Shimojo H, Kashihara T, Nishio A, Suzuki S, Mende U, Matsumoto K, Matsushita N, Taira E, Sato F, Yamada M
PLOS ONE, 7(12), e52667, 2012, Refereed - Decrease in the density of t-tubular L-type Ca2+ channel currents in failing ventricular myocytes
Horiuchi-Hirose M, Kashihara T, Nakada T, Kurebayashi N, Shimojo H, Shibazaki T, Sheng X, Yano S, Hirose M, Hongo M, Sakurai T, Moriizumi T, Ueda H, Yamada M
Am. J. Physiol. Heart Circ. Physiol., 300(3), H978–H988, Mar. 2011, Refereed - Diacylglycerol kinase ζ inhibits ventricular tachyarrhythmias in a mouse model of heart failure: Roles of canonical transient receptor potential (TRPC) channels.
Hirose M, Takeishi Y, Niizeki T, Nakada T, Shimojo H, Kubota I, Mende U, Yamada M.
Circ. J., 75(10), 2333–2342, 2011, Refereed - Nicorandil ameliorates impulse conduction disturbances during ischemia in isolated arterially perfused canine atria.
Hirose M, Yano S, Nakada T, Horiuchi-Hirose M, Tsujino N, Yamada M
Int. J. Cardiol., 146(1), 37–43, 2011, Refereed - Rh glycoprotein expression is modulated in pufferfish (Takifugu rubripes) during high environmental ammonia exposure.
Nawata CM, Hirose S, Nakada T, Wood CM, Kato A.
J. Exp. Biol., 213(Pt 18), 3150-3160, Sep. 2010, Refereed - Selective α1A-adrenoceptor stimulation induces Mueller’s smooth muscle contraction in an isolated canine upper eyelid preparation.
Yano S, Hirose M, Nakada T, Nakayama J, Matsuo K, Yamada M.
Curr. Eye Res., 35(5), 363–369, May 2010, Refereed - From blood typing to a transport metabolon at a crossroad. Focus on "Ammonium-dependent sodium uptake in mitochondrion-rich cells of medaka (Oryzias latipes) larvae".
Hirose S, Nakada T
American journal of physiology. Cell physiology, 298(2), C209-10, Feb. 2010, Refereed - Rhesus glycoprotein p2 (Rhp2) is a novel member of the Rh family of ammonia transporters highly expressed in shark kidney.
Nakada T, Westhoff CM, Yamaguchi Y, Hyodo S, Li X, Muro T, Kato A, Nakamura N, Hirose S
J. Biol. Chem., 285(4), 2653-2664, Jan. 2010, Refereed - Identification of renal transporters involved in sulfate excretion in marine teleost fish.
Kato A, Chang MH, Kurita Y, Nakada T, Ogoshi M, Nakazato T, Doi H, Hirose S, Romero MF.
American journal of physiology. Cell physiology, 297(6), R1647–R1659, Dec. 2009, Refereed - Diacylglycerol kinase ζ inhibits Gαq-induced atrial remodeling in transgenic mice.
Hirose M, Takeishi Y, Niizeki T, Shimojo H, Nakada T, Kubota I, Nakayama J, Mende U, Yamada M.
Heart Rhythm, 6(1), 78-84, Jan. 2009, Refereed - Mechanisms of preventive effect of nicorandil on ischemia-induced ventricular tachyarrhythmia in isolated arterially perfused canine left ventricular.
Hirose M, Tsujino N, Nakada T, Yano S, Imamura H, Yamada M.
Basic Clin. Pharmacol. Toxiocol., 102(6), 504-514, Jun. 2008, Refereed - Contribution of L-type Ca2+ channels to early afterdepolarizations induced by IKr and IKs channel suppression in guinea-pig ventricular myocytes.
Yamada M, Ohta K, Niwa A, Tsujino N, Nakada T, Hirose M.
J. Membr. Biol., 222(3), 151-166, Apr. 2008, Refereed - Identification of intestinal bicarbonate transporters involved in formation of carbonate precipitates to stimulate water absorption in marine teleost fish.
Kurita Y, Nakada T, Kato A, Doi H, Mistry AC, Chang MH, Romero MF, Hirose S.
Am. J. Physiol. Regul. Integr. Comp. Physiol., 294(4), R1402-R1412, Apr. 2008, Refereed - Localization of ammonia transporter Rhcg1 in mitochondrion-rich cells of yolk sac, gill, and kidney of zebrafish and its ionic strength-dependent expression.
Nakada T, Hoshijima K, Esaki M, Nagayoshi S, Kawakami K, Hirose S.
Am. J. Physiol. Regul. Integr. Comp. Physiol., 293, 1743-1753, Oct. 2007, Refereed - Ammonia secretion from fish gill depends on a set of Rh glycoproteins.
NakadaT, Westhoff CM, Kato A, Hirose S.
FASEB J., 21(4), 1067-1074, Apr. 2007, Refereed - Molecular and functional characterization of adrenomedullin receptors in pufferfish.
Nag K, Kato A, Nakada T, Hoshijima K, Mistry AC, Takei Y, Hirose S.
Am. J. Physiol. Regul. Integr. Comp. Physiol., 290(2), R467-R478, Feb. 2006, Refereed - Takifugu obscurus is a euryhaline fugu species very close to Takifugu rubripes and suitable for studying osmoregulation.
Kato A, Doi H, Nakada T, Sakai H, Hirose S
BMC physiology, 5, 18, Dec. 2005, Refereed - Roles of Slc13a1 and Slc26a1 sulfate transporters of eel kidney in sulfate homeostasis and osmoregulation in freshwater.
Nakada T, Zandi-Nejad K, Kurita Y, Kudo H, Broumand V, Kwon CY, Mercado A, Mount DB, Hirose S
American journal of physiology. Regulatory, integrative and comparative physiology, 289(2), R575-R585, Aug. 2005, Refereed - Molecular cloning and characteristics of a novel zinc finger protein and its splice variant whose transcripts are expressed during spermatogenesis.
Ishizuka M, Ohshima H, Tamura N, Nakada T, Inoue A, Hirose S, Hagiwara H
Biochemical and biophysical research communications, 301(4), 1079-1085, Feb. 2003, Refereed
