SHINDO TAKAYUKI
Academic Assembly School of Medicine and Health Sciences Institute of Medicine
Interdisciplinary Cluster for Cutting Edge Research Institute for Biomedical Sciences
Professor
Researcher Information
Research Keyword
- Cardiovascular Research, Mice Gene Engineering
TEL
- +81-263-37-2578
Mail Address
- tshindo★shinshu-u.ac.jp
Career
Research activity information
Paper
- Role of adrenomedullin-2/intermedin in the pathogenesis of neovascular age-related macular degeneration.
Kakihara S, Matsuda Y, Hirabayashi H, Imai A, Iesato Y, Sakurai T, Kamiyoshi A, Tanaka M, Ichikawa-Shindo Y, Kawate H, Zhao Y, Zhang Y, Guo Q, Li P, Onishi N, Murata T, Shindo T.
Lab Invest., 103(4), 100038, 2023 - Calcitonin gene-related peptide is not involved in neuropathic pain induced by partial sciatic nerve ligation in mice.
Ishida K, Tanaka S, Shen D, Matsui S, Fuseya S, Shindo, Kawamata M.
Neurosci Lett., 778, 136615, 2022 - Studies on safety and efficacy of particles containing a mixture of hydroxyapatite–argentum–titanium oxide (HAT) and sheets coated with HAT particles to be used in masks to improve nasal allergy: I. In vitro studies.
Okazaki N, Yamaki D, Takei T, Shimizu M, Kamatani N, Shindo T.
The Allergy in Practice, 42(3), 37-46, 2022 - Studies on safety and efficacy of particles containing a mixture of hydroxyapatite-argentum-titanium oxide (HAT) and sheets coated with HAT particles to be used in masks to improve nasal allergy: II. Cellular, in vivo, and clinical studies.
Okazaki N, Yamaki D, Takei T, Shimizu M, Kamatani N, Shindo T.
Eur Arch Otorhinolaryngol., 279(9), 4425-4433, 2022 - Receptor activity modifying protein RAMP sub-isoforms and their functional differentiation, which regulates functional diversity of adrenomedullin.
Shindo T, Tanaka M, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Sakurai T.
Biology., 11(5), 788, 2022 - An Myh11 single lysine deletion causes aortic dissection by reducing aortic structural integrity and contractility.
Negishi K, Aizawa K, Shindo T, Suzuki T, Sakurai T, Saito Y, Miyakawa T, Tanokura M, Kataoka Y, Maeda M, Tomida S, Morita M, Kario K, Nagai R, Imai Y.
Sci Rep., 12(1), 8844, 2022 - Mid-regional pro-adrenomedullin is a novel biomarker for arterial stiffness as the criterion for vascular failure in a cross-sectional study.
Koyama T, Kuriyama N, Suzuki Y, Saito S, Tanaka R, Iwao M, Tanaka M, Maki T, Itoh H, Ihara M, Shindo T, Uehara R.
Sci Rep., 11(1), 305, 2021 - Adrenomedullin-RAMP2 system ameliorates subretinal fibrosis by suppressing epithelial-mesenchymal transition in age-related macular degeneration.
Tanaka M, Kakihara S, Hirabayashi K. Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Cui N, Wei Y, Zhao Y, Aruga K, Yamauchi A, Murata M, Shindo T.
Am J Pathol., 191(4), 652-668, 2021 - Production of single- and multiple-gene-modified mice via maternal SpCas9-based gene editing.
Sakurai T, Shindo T.
STAR Protoc., 2(2), 100509, 2021 - Adrenomedullin-RAMP2 and -RAMP3 Systems Regulate Cardiac Homeostasis during Cardiovascular Stress.
Cui N, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Tanaka M, Wei Y, Kakihara S, Zhao Y, Aruga K, Kawagishi H, Nakada T, Yamada M, Shindo T.
Endocrinology., 162(3), 1-20, 2021 - Adrenomedullin-RAMP2 system ameliorates pulmonary fibrosis by regulating TGF-β-Smads pathway and differentiation of myofibroblasts.
Wei Y, Tanaka M, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Cui1 N, Kakihara S, Zhao Y, Aruga K, Sanjo H, Shindo T.
Endocrinology., 162(8), 1-22, 2021 - Production of genetically engineered mice with higher efficiency, lower mosaicism, and mulitiplexing capability using maternally expressed Cas9.
Sakurai T, Kamiyoshi A, Kawate H, Watanabe S, Sato M, Shindo T.
Sci Rep., 10(1):1091,, 2020 - Placental extract ameliorates liver fibrosis in a methionine- and choline-deficient diet-induced mouse model of non-alcoholic steatohepatitis.
Yamauchi A. Tone T, Tokedo A, Igarashi K, Sugimoto K, Miyai H, Deng D, Nakamura J, Lim HS, Kaku T, Hirano E, Shindo T.
Biomedical Research., 41(1), 1–12, 2020 - Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts.
Dai K, Tanaka M, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Cui N, Wei Y, Tanaka M, Kakihara S, Matsui S, Shindo T.
Oncogene., 39(9), 1914-1930, 2020 - Investigation of the therapeutic mechanism of subthreshold micropulse laser irradiation in retina.
Hirabayashi K, Kakihara S, Tanaka M, Shindo T, Murata T.
Graefes Arch Clin Exp Ophthalmol., 285(5), 1039-1047, 2020 - Bindel-PCR: a novel and convenient method for identifying CRISPR/Cas9-induced biallelic mutants through modified PCR using Thermus aquaticus DNA polymerase
Sakurai T, Kamiyoshi A, Takei N, Watanabe S, Sato M , Shindo T.
Sci Rep, 9:9923., 2019 - Regulation of cardiovascular development and homeostasis by the adrenomedullin-RAMP system
Shindo T, Tanaka M, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Sakurai T
Peptides., 111, 55-61, 2019 - Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism
Yamauchi A. Kamiyoshi A, Sakurai T, Miyazaki H, Hirano E, Lim HS, Kaku T, Shindo T. Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism
Heliyon., 10;5(5):e01637, 2019 - Placental extract suppresses cardiac hypertrophy and fibrosis in an angiotensin II-induced cachexia model in mice
Yamauchi A, Kamiyoshi A, Sakurai T, Miyazaki H, Hirano E, Lim HS, Kaku T, Shindo T.
Heliyon., 5(10):e02655., 2019 - Development of a novel model of central retinal vascular occlusion and therapeutic potential of adrenomedullin-RAMP2 system
Hirabayashi K, Tanaka M, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Dai K, Cui N, Wei Y, Nakamura K, Iida S, Matsui S, Yamauchi A, Murata T, Shindo T
Am J Pathol., 189(2), 449-466, 2019 - Endogenous Calcitonin Gene-Related Peptide Deficiency Exacerbates Postoperative Lymphedema by Suppressing Lymphatic Capillary Formation and M2 Macrophage Accumulation.
Matsui S, Tanaka M, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Dai K, Cui N, Wei Y, Tanaka M, Kakihara S, Nakamura K, Yamauchi A, Ishida K, Tanaka S, Kawamata M, Shindo T.
Am J Pathol., 189(12), 2487-2502, 2019 - Porcine placental extract facilitates memory and learning in aged mice.
Yamauchi A, Tone T, Sugimoto K, Lim HS, Kaku T, Tohda C, Shindo T, Tamada K, Mizukami Y, Hirano E.
Food Sci Nutr., (7), 2995–3005, 2019 - RAMP3 deficiency enhances postmenopausal obesity and metabolic disorders
Liu T, Kamiyoshi A, Tanaka M, Iida S, Sakurai T, Ichikawa-Shindo Y, Kawate H, Hirabayashi K, Dai K, Cui N, Tanaka M, Wei Y, Nakamura K, Matsui S, Yamauchi A, Shindo T
Peptides., 110, 10-18, 2018 - Endogenous calcitonin gene-related peptide suppresses ischemic brain injuries and progression of cognitive decline
Zhai L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Xian X, Hirabayashi K, Dai K, Cui N, Tanimura K, Liu T, Wei Y, Tanaka M, Tomiyama H, Yamauchi A,Igarashi K, Shindo T
J Hypertens., 36(4), 876-891, 2018 - Endogenous Calcitonin Gene-Related Peptide Regulates Lipid Metabolism and Energy Homeostasis in Male Mice.
Liu T, Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y, Kawate H, Yang L, Tanaka M, Xian X, Imai A, Zhai L, Hirabayashi K, Dai K, Tanimura K, Liu T, Cui N, Igarashi K, Yamauchi A, Shindo T.
Endocrinology., 158(5), 1194-1206, 2017 - Vasoprotective Activities of the Adrenomedullin-RAMP2 System in Endothelial Cells.
Xian X, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Tanaka M, Koyama T, Kawate H, Yang L, Liu T, Imai A, Zhai L, Hirabayashi K, Dai K, Tanimura K, Liu T, Cui N, Igarashi K, Yamauchi A, Shindo T.
Endocrinology., 158(5), 1359−1372, 2017 - Adrenomedullin suppresses vascular endothelial growth factor-induced vascular hyperpermeability and Inflammation in retinopath
Imai A, Toriyama Y, Iesato Y, Hirabayashi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Liu T, Xian X, Zhai L, Dai K, Tanimura K, Liu T, Cui N, Yamauchi A, Murata T, Shindo T"
Am J Phthol., 187(5), 999-1015, 2017 - The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumour metastasis.
Tanaka M, Koyama T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Liu T, Xian X, Imai A, Zhai L, Hirabayashi K, Owa S, Yamauchi A, Igarashi K, Taniguchi S, Shindo T.
Cardiovasc Res, 111(4), 398-409, Sep. 2016 - Pathophysiological Function of Endogenous Calcitonin Gene-Related Peptide in Ocular Vascular Diseases
Toriyama Y, Iesato Y, Imai A, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Igarashi K, Tanaka M, Liu T, Xian X, Zhai L, Owa S, Murata T, Shindo T.
Am J Pathol., 185(6), 1783-1794, 2015 - Pathophysiological roles of adrenomedullin-RAMP2 system in acute and chronic cerebral ischemia
Igarashi K, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L, Owa S, Arai T, Shindo T.
Peptides., 62, 21-31, 2014 - Functional differentiation of RAMP2 and RAMP3 in their regulation of vascular system
Yamauchi A, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Igarashi K, Toriyama Y, Tanaka M, Liu T, Xian X, Imai A, Zhai L, Owa S, Arai T, Shindo T.
J Mol Cell Cardiol., 77, 73-85, 2014 - Adrenomedullin-RAMP2 System Suppresses ER Stress-Induced Tubule Cell Death and Is Involved in Kidney Protection
Uetake R, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Yoshizawa T, Koyama T, Yang L, Toriyama Y, Yamauchi A, Igarashi K, Tanaka M, Kuwabara T, Mori K, Yanagita M, Mukoyama M, Shindo T.
PLOS ONE, 9(2), e87667, 2014 - Calcitonin Gene-related Peptide Is Involved in Inflammatory Pain but Not in Postoperative Pain.
Ishida K, Kawamata T, Tanaka S, Shindo T, Kawamata M.
Anesthesiology., 121(5), 1068-79, 2014 - Pathophysiological roles of adrenomedullin and its receptor activity modifying system.
Shindo T, Sakurai T, Kamiyoshi A, Shindo Y, Kawate H, Koyama T.
Folia Pharmacol. Jpn, 143(5), 232-235, 2014 - Endogenous CGRP protects against neointimal hyperplasia following wire-induced vascular injury
Yang L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yoshizawa T, Koyama T, Iesato Y, Uetake R, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Shindo T.
J Mol Cell Cardiol., 59, 55-66, 2013 - Vascular Endothelial Adrenomedullin-RAMP2 System Is Essential for Vascular Integrity and Organ Homeostasis
Koyama T, Ochoa-Callejero L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Arai T, Yoshizawa T, Iesato Y, Lei Y, Uetake R, Okimura A, Yamauchi A, Tanaka M, Igarashi K, Toriyama Y, Kawate H, Adams R.H, Kawakami H, Mochizuki N, Martínez A, Shindo T
Circulation, 127(7), 842-853, 2013 - Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-RAMP2 system
Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T.
Hypertension, 61(2), 341-351, 2013 - Adrenomedullin-RAMP2 System Is Crucially Involved in Retinal Angiogenesis
Iesato Y, Toriyama Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yoshizawa T, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Igarashi K, Murata T, Shindo T
Am J Pathol., 182(6), 2380-2390, 2013 - Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding.
Kusano S, Kukimoto-Niino M, Hino N, Ohsawa N, Okuda K, Sakamoto K, Shirouzu M, Shindo T, Yokoyama S.
Protein Sci., 21, 199-210, 2012 - Adrenomedullin-RAMP2 system in cardiovascular development and homeostasis
Shindo T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y.
Curr Hypertens Rev., 7(4), 217-227, 2011 - Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling
Arai T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Iesato Y, Koyama T, Yoshizawa T, Uetake R, Yamauchi A, Yang L, Kawate H, Ogawa S, Kobayashi A, Miyagawa S, Shindo T.
PEPTIDES, 32(9), 1855-1865, 2011 - Adrenomedullin in sinusoidal endothelial cells play protective roles against cold injury of liver
Iinuma, Nobuyoshi; Sakurai, Takayuki; Kamiyoshi, Akiko; Ichikawa-Shindo, Yuka; Arai, Takuma; Yoshizawa, Takahiro; Koyama, Teruhide; Uetake, Ryuichi; Kawate, Hisaka; Muto, Shin-ichi; Tagawa, Yoh-ichi; Miyagawa, Shinichi; Shindo, Takayuki
PEPTIDES, 31(5), 865-871, May 2010 - Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload.
Takeda N, Manabe I, Uchino Y, Eguchi K, Matsumoto S, Nishimura S, Shindo T, Nagai R.
J Clin Invest., 120(1), 254-65, 2010 - Endogenous a-CGRP mitigates liver fibrosis in chronic hepatitis induced by repeated administration of concanavalin A.
Kamiyoshi A, Sakurai T, Ichikawa-Shindo Y. Iinuma N, Kawate H, Yoshizawa T, Koyama T, Muto S, Shindo T.
Liver International., 29(5), 642-9, 2009 - Regulation of angiogenesis and vascular integrity by adrenomedullin-RAMP2 system.
Shindo Y, Sakurai T, Kamiyoshi A, Koyma T, Yoshizawa T, Shindo T.
J Soc Circ Res., 32(2), 33-35, 2009 - Rapid zygosity determination in mice by SYBR Green real-time genomic PCR of a crude DNA solution.
Sakurai T, Kamiyoshi A, Watanabe S, Sato M, Shindo T.
Transgenic Res., 17, 149-55, 2008 - GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity.
Ichikawa-Shindo Y, Sakurai T, Kamiyoshi A, Kawate H, Iinuma N, Yoshizawa T, Koyama T, Fukuchi J, Iimuro S, Moriyama N, Kawakami H, Murata T, Kangawa K, Nagai R, Shindo T.
J Clin Invest., (118), 29-39, 2008 - Crystal structure of the human receptor activity-modifying protein 1 extracellular domain
Kusano S, Kukimoto-Niino M, Akasaka R, Toyama M, Terada T, Shirouzu M, ShindoT, Yokoyama S.
Protein Sci., 17(11), 1907-14, 2008 - Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9.: Shinoda Y, Ogata N,
Higashikawa A, Manabe I,Shindo T, Yamada T, Kugimiya F, Ikeda T, Kawamura N, Kawasaki Y, Tsushima K, Takeda N, Nagai R, Hoshi K, Nakamura K, Chung UI, Kawaguchi H.
J Biol Chem., 283(36), 24682-9, 2008 - Adrenomedullin insufficiency increases allergen-induced airway hyperresponsiveness in mice.
Yamamoto H, Nagase T, Shindo T, Teramoto S, Aoki-Nagase T, Yamaguchi Y, Hanaoka Y, Kurihara H, Ouchi Y
J Appl Physiol., 102(6), 2361-8, 2007 - Significance of the transcription factor KLF5 in cardiovascular remodeling
Nagai R, Suzuki T, Aizawa K, Shindo T, Manabe I
J ThrombHaemost, 343, 1569-1576, 2005 - Synthetic Retinoid Am80 Suppresses Smooth Muscle Phenotypic Modulation and In-Stent Neointima Formation by Inhibiting KLF5
Fujiu K, Manabe I, Ishihara A, Oishi Y, Iwata H, Nishimura G, Shindo T, Maemura K, Kagechika H, Shudo K, Nagai R
Circ Res, 97, 1132-1141, 2005 - Kruppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation
Oishi Y, Manabe I, Tobe K, Tsushima K, Shindo T, Fujiu K, Nishimura G, Maemura K, Yamauchi T, Kubota N, Suzuki R, Kitamura T, Akira S, Kadowaki T, Nagai R
Cell Metabolism, 1, 27-29, 2005 - Protective effects of endogenous adrenomedullin on cardiac hypertrophy, fibrosis and renal damage
Niu P, Shindo T, Iwata H, Iimuro S, Takeda N, Zhang Y, Ebihara A, Suematsu Y, Kangawa K, Hirata Y, Nagai R
Circulation, 109, 1789-1794, 2004 - Angiogenic effects of adrenomedullin in ischemia and tumor growth
Iimuro S, Shindo T, Moriyama N, Amaki T, Niu P, Takeda N, Iwata H, Zhang Y, Ebihara A, Nagai R
Circ Res, 95, 415-423, 2004 - Unique roles of G protein-coupled histamine H2 and gastrin receptors in growth and differentiation of gastric mucosa
Fukushima Y, Matsui T, Saitoh T, Ichinose M, Tateishi K, Shindo T, Fujishiro M, Sakoda H, Shojima N, Kushiyama A, Fukuda S, Anai M, Ono H, Oka M, Shimizu Y, Kurihara H, Nagai R, Ishikawa T, Asano T, Omata M
Eur J Pharmacol, 502, 243-252, 2004 - KLF5/BTEB2, a Kruppel-like zinc-finger type transcription factor, mediates both smooth muscle cell activation and cardiac hypertrophy.
Nagai R, Shindo T, Manabe I, Suzuki T, Kurabayashi M
Adv Exp Med Biol, 538, 57-65, 2003 - Accelerated cardiac hypertrophy and renal damage induced by angiotensin II in adrenomedullin knockout mice.
Niu P, Shindo T, Iwata H, Ebihara A, Suematsu Y, Zhang Y, Takeda N, Iimuro S, Hirata Y, Nagai R
Hypertens Res, 26, 731-736, 2003 - Targeted disruption of adrenomedullin and alphaCGRP genes reveals their distinct biological roles.
Kurihara H, Shindo T, Oh-Hashi Y, Kurihar Y, Kuwaki T
Hypertens Res, 26, S105-8, 2003 - Endothelial responses of the aorta from adrenomedullin transgenic mice and knockout mice.
Nishimatsu H, Hirata Y, Shindo T, Kurihara H, Suzuki E, Sata M, Satonaka H, Takeda R, Nagata D, Kakoki M, Hayakawa H, Kangawa K, Matsuo H, Kitamura T, Nagai R
Hypertens Res, 26, S79-84, 2003 - Structural and functional characterization of gastric mucosa and central nervous system in histamine H(2) receptor-null mice.
Fukushima Y, Shindo T, Anai M, Saitoh T, Wang Y, Fujishiro M, Ohashi Y, Ogihara T, Inukai K, Ono H, Sakoda H, Kurihara Y, Honda M, Shojima N, Fukushima H, Haraikawa-Onishi Y, Katagiri H, Shimizu Y, Ichinose M, Ishikawa T, Omata M, Nagai R, Kurihara H, Asano T
Eur J Pharmacol, 468(1), 47-58, 2003 - Gene expression in fibroblasts and fibrosis. Involvement in cardiac hypertrophy.
Gene expression in fibroblasts and fibrosis. Involvement in cardiac hypertrophy.
Circ Res, 27, 1103-1113, 2002 - Protective effect of adrenomedullin against cardiac hypertrophy and renal damage.
Niu P, Shindo T, Ebihara A, Zhang Y, Kawanami D, Imai Y, Amaki T, Suematsu Y, Nagai R
J Cardiac Failure, 8, S221, 2002 - A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 null mutant mice develop renal lesions mimicking obstructive nephropathy.
Yokoyama H, Wada T, Kobayashi K, Kuno K, Kurihara H, Shindo T, Matsushima K
Nephrol Dial Transplant, 17, 39-41, 2002 - Regulation of angiogenesis by the aging suppressor gene klotho.
Fukino K, Suzuki T, Saito Y, Shindo T, Amaki T, Kurabayashi M, Nagai R
Biochem Biophys Res Commun, 293, 332-7, 2002 - Role of endogenous adrenomedullin in the regulation of vascular tone and ischemic renal injury. Studies on transgenic/knockout mice of adrenomedullin gene.
Nishimatsu H, Hirata Y, Shindo T, Kurihara H, Kakoki M, Nagata D, Hayakawa H, Satonaka H, Sata M, Tojo A, Suzuki E, Kangawa K, Matsuo H, Kitamura T, Nagai R
Circ Res, 90, 657-63, 2002 - Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient mice.
Aoki-Nagase T, Nagase T, Oh-Hashi Y, Shindo T, Kurihara Y, Yamaguchi Y, Yamamoto H, Tomita T, Ohga E, Nagai R, Kurihara H, Ouchi Y
Am J Physiol Lung Cell Mol Physiol, 283(5), L963-70, 2002 - Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling.
Shindo T, Manabe I, Fukushima Y, Tobe K, Aizawa K, Miyamoto S, Kawai-Kowase K, Moriyama N, Imai Y, Kawakami H, Nishimatsu H, Suzuki T, Morita H, Maemura K, Sata M, Komukai M, Kagechika H, Kadowaki T, Kurabayashi M, Nagai R
Nature Medicine, 8(8), 856-63, 2002 - Resistance to neointimal hyperplasia and fatty streak formation in adrenomedullin overexpression mice.
Imai Y, Shindo T, Maemura K, Sata M, Saito Y, Kurihara Y, Akishita M, Osuga J, Ishibashi S, Tobe K, Morita H, Oh-hashi Y, Suzuki T, Maekawa H, Kangawa K, Minamino N, Yazaki Y, Nagai R, Kurihara H
Arterioscler Thromb Vasc Biol, 22(8), 1310-5, 2002 - Renal damage and salt-dependent hypertension in aged transgenic mice overexpressing endothelin-1.
Shindo T, Kurihara H, MaemuraK, Kurihara Y, Ueda O, Suzuki H, Kuwaki T, Ju K-H, Wang Y, Ebihara A, Nishimatsu H, Moriyama N, Fukuda M, Akimoto Y, Hirano H, Morita H, Kumada M, Yazaki Y, Nagai R, Kimura K
J. Mol. Med, 80(2), 105-16, 2002 - Evidence for the physiological and pathological roles of adrenomedullin from genetic engineering in mice.
Imai Y, Shindo T, Maemura K, Kurihara Y, Ryozo N, Kurihara H
Ann N Y Acad Sci, 947, 26-33, 2001 - Elevated sympathetic nervous activity in mice deficient in aCGRP.
Oh-hashi Y,* Shindo T* (*double 1st author), Kurihara Y, Imai T, Wang Y, Morita H, Imai Y, Kayaba Y, Nishimatsu H, Suematsu Y, Hirata Y, Yazaki Y, Nagai R, Kuwaki T, Kurihara H
Circ Res, 89, 983-90, 2001 - Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene.
Shindo T, Kurihara Y, Nishimatsu H, Moriyama N, Kakoki M, Wang Y, Imai Y, Ebihara A, Kuwaki T, Ju K-H, Minamino N, Kangawa K, Ishikawa T, Fukuda M, Akimoto Y, Kawakami H, Imai T, Morita H, Yazaki Y, Nagai R, Hirata H, Kurihara H
Circulation, 104, 1964-71, 2001 - Vascular smooth muscle cell-directed overexpression of heme oxygenase-1 elevates blood pressure through attenuation of nitric oxide-induced vasodilation in mice.
Imai T, Morita T, Shindo T, Nagai R, Yazaki Y, Kurihara H, Suematsu M, Katayama S
Circ Res, 89(1), 55-62, 2001 - Diet-induced hyperhomocysteinemia exacerbates neointima formation in rat carotid arteries after balloon injury.
Morita H, Kurihara H, Yoshida S, Saito Y, Shindo T, Oh-Hashi Y, Kurihara Y, Yazaki Y, Nagai R
Circulation, 103(1), 133-9, 2001 - ADAMTS-1: A metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphologyand function.
Shindo T, Kurihara H, Kuno K, Yokoyama H, Wada T, Kurihara Y, Imai T, WangY, Oh-hashi Y, Morita H, Ishikawa T, Yazaki Y, Matsushima K
J Clin Invest, 105(10), 1345-52, 2000 - Hypotension and resistance to lipopolysaccharide-induced shock in transgenic mice overexpressing
Shindo T, Kurihara H, Maemura K, Kurihara Y, Kuwaki T, Izumida T, Minamino N, Ju K, Morita H, Oh-hashi Y, Kumada M, Kangawa K, Nagai R, Yazaki Y
Circulation, 101(19), 2309-16, 2000 - Evidence for association between paraoxonase gene polymorphisms and atherosclerotic diseases.
Imai Y, Morita H, Kurihara H, Sugiyama T, Kato N, Ebihara A, Hamada C, Kurihara Y, Shindo T, Oh-hashi Y, Yazaki Y
Atherosclerosis, 149(2), 435-42, 2000 - Responses of blood pressure and catecholamine metabolism to high salt loading in endothelin-1 knockout mice.
Morita H, Kurihara H, Kurihara Y, Kuwaki T, Shindo T, Oh-hashi Y, Kumada M, Yazaki Y
Hypertens Res, 22(1), 11-6, 1999 - Polymorphism of the methionine synthase gene : association with homocysteine metabolism and late-onset vascular diseases in the Japanese population.
Morita H, Kurihara H, Sugiyama T, Hamada C, Kurihara Y, Shindo T, Oh-hashi Y, Yazaki Y
Arterioscler Thromb Vasc Biol, 19(2), 298-302, 1999 - Upregulation of endothelin-1 and adrenomedullin gene expression in the mouse endotoxin shock model.
Shindo T, Kurihara H, Kurihara Y, Morita H, Yazaki Y
J Cardiovasc Pharmacol, 31, S541-4, 1998 - Cardiac sarcoidosis.
Shindo T, Kurihara H, Ohishi N, Morita H, Maemua K, Kurihara Y, Tsuneyoshi H, Chi H, Yamaoki K, Yazaki Y
Circulation, 97(13), 1306-7, 1998 - Systemic and renal response to salt loading in endothelin-1 knockout mice.
Morita H, Kurihara H, Kurihara Y, Shindo T, Kuwaki T, Kumada M, Yazaki Y
J Cardiovasc Pharmacol, (31), S557-60, 1998 - Methylenetetrahydrofolate reductase gene polymorphism and ischemic stroke in Japanese.
Morita H, Kurihara H, Tsubaki S, Sugiyama T, Hamada C, Kurihara Y, Shindo T, Oh-hashi Y, Kitamura K, Yazaki Y
Arterioscler Thromb Vasc Biol, 18(9), 1465-9, 1998 - Genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) as a risk factor forcoronary artery disease.
Morita H, Taguchi J, Kurihara H, Kitaoka M, Kaneda H, Kurihara Y, Maemura K, Shindo T, Minamino T, Ohno M, Yamaoki K, Ogasawara K, Aizawa T, Suzuki S, Yazaki Y
Circulation, 95(8), 2032-6, 1997 - Nitric oxide synthesis in cardiac myocytes and fibroblasts by inflammatory cytokines.
Shindo T, Ikeda U, Ohkawa F, Kawahara Y, Yokoyama M, Shimada K
Cardiovasc Res, 29(6), 813-9, 1995 - Nitric oxide synthesis in rat cardiac myocytes and fibroblasts.
Shindo T, Ikeda U, Ohkawa F, Takahashi M, Funayama H, Nishinaga M, Kawahara Y, Yokoyama M, Kasahara T, Shimada K
Life Sci., 55(14), 1101-8, 1994
Books and other publications
- Methods Mol Biol. 1874
Sakurai T, Kamiyoshi A, Ohtsuka M, Gurumurthy CB, Sato M, Shindo T., Isolation and analysis of a genome-edited single-hepatocyte from a Cas9 transgenic mouse line.
257-271 2019Springer
Sakurai T, Shindo T, Sato M, Oocytes Maternal information and functions
495-510 2017Results Probl Cell Differ. 63
Sakurai T, Shindo T, Sato M., Noninheritable maternal factors useful for genetic manipulation in mammals.
495-510 2017Knockout mice and transgenic mice. Nishikimi T eds: Adrenomedullin in Cardiovascular Disease
Springer, New Jersey, pp 167-173 2005Lectures, oral presentations, etc.
- Investigation of the therapeutic effect of adrenomedullin on experimental autoimmune uveitis.
Matsuda Y, Kakihara S, Hirabayashi K, Imai A, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Tanaka M, Kawate H, Zhao Y, Murata T, Shindo T
The Association for Research in Vision and Ophthalmology (ARVO) 2023, 23 Apr. 2023Role of adrenomedullin-2/intermedin in the pathogenesis of neovascular AMD.
Kakihara S, Matsuda Y, Hirabayashi K, Imai A, Iesato Y, Sakurai T, Kamiyoshi A, Tanaka M, Ichikawa-Shindo Y, Kawate H, Zhao Y, Murata T, Shindo T
FujiRetina2023 , 25 Mar. 2023Endogenous adrenomedullin 2 /intermedin exerts cardioprotective effects against pressure overload.
Zhao Y, Sakurai T, Kamiyoshi K, Ichikawa-Shindo Y, Kawate H, Tanaka M, Kakihara S, Matsuda Y, Zhang Y, Guo Q, Li P, Onishi N, Kasahara T, Shindo T.
第87回日本循環器学会, 10 Mar. 2023Adrenomedullin-2/intermedin ameliorates pathological angiogenesis and associated inflammation and fibrotic lesions via Meox2.
Kakihara S, Matsuda Y, Sakurai T, Kamiyoshi K, Tanaka M, Ichikawa-Shindo Y, Kawate H, Zhao Y, Zhang Y, Guo Q, Li P, Onishi N, Kasahara T, Shindo T.
第87回日本循環器学会, 10 Mar. 2023Vascular homeostatic function of the AM-RAMP2 system and its application to the regulation of lymph node metastasis.
Tanaka M, Sakurai T, Kamiyoshi K, Ichikawa-Shindo Y, Kawate H, Kakihara S, Zhao Y, Matsuda Y, Zhang Y, Guo Q, Li P, Onishi N, Kasahara T, Shindo T.
第87回日本循環器学会, 10 Mar. 2023Transcriptome analysis of the pathophysiological significance of adrenomedullin 2 in the mouse choroidal neovascularization model.
Kakihara K, Sakurai T, Kamiyoshi A, Tanaka M, Kawate H, Ichikawa-Shindo Y, Zhao Y, Matsuda Y, Hirabayashi K, Imai A, Iesato Y, Murata T, Shindo T.
The Association for Research in Vision and Ophthalmology (ARVO) 2022, 14 May 2022Investigation of the therapeutic effect of adrenomedullin on experimental autoimmune uveitis.
Matsuda Y, Kakihara S, Hirabayashi K, Imai A, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo, Y, Tanaka M, Kawate H, Zhao Y, Murata T, Shindo T.
The Association for Research in Vision and Ophthalmology (ARVO) 2022, 14 May 2022Pathophysiological roles of adrenomedullin-2 in mouse model of ocular neovascularization.
Kakihara S, Tanaka M, Hirabayash K, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Kawate H, Ichikawa-Shindo Y, Tanaka M, Murata T, Shindo T.
The Association for Research in Vision and Ophthalmology (ARVO) 2021, 01 May 2021Adrenomedullin-RAMP2 and RAMP3 systems regulate cardiac homeostasis against cardiovascular stresses
Cui N, Sakurai T, Kamiyoshi A, Shindo Y, Kawate H, Tanaka M, Dai K, Wei Y, Tanaka M. Kakihara S, Matsui S, Shindo T.
Asian Pacific Society of Cardiology Congress 2020 (APSC2020), 27 Jul. 2020Pathophysiological significance of adrenomedullin-RAMP2 system in age-related macular degeneration
Masaaki Tanaka, Kazutaka Hirabayashi, Yasuhiro Iesato, Akira Imai, Yuichi Toriyama, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Megumu Tanaka, Akihiro Yamauchi, Toshinori Murata, Takayuki Shindo
Association for research in Vision and Ophthalmology, 28 Apr. 2019Development of a retinal vascular occlusion model in mice and analysis of the pathophysiological roles of adrenomedullin
Kazutaka Hirabayashi, Toshinori Murata, Takayuki Shindo, Masaaki Tanaka, Akira Imai
Congress of Asia-Pacific Academy of Ophthalmology, 06 Mar. 2019Investigation of the therapeutic effect of adrenomedullin on central retinal vein occlusion
Kazukata Hirabayashi, Toshinori Murata, Yasuhiro Iesato, Akira Imai, Yuichi Toriyama, Masaaki Tnanaka, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Megumu Tanaka, Akihiro Yamauchi, Takayuki Shindo
The Association for Research in Vision and Ophthalmology, 28 Apr. 2018Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis
Shindo T.
The Conference on Bioactive Peptides for Cell-Cell Communication 2014 Symposium, 11 Sep. 2014Vasoactive peptides and their receptor regulation system.
新藤隆行
2010, InvitedPathophysiological roles and potential applications of vasoactive peptides and their receptor regulation system.
新藤隆行
2010, InvitedPathophysiological roles of Adrenomedullin-RAMP system in cardiovascular diseases
新藤隆行
2008, InvitedAdrenomedullin and cardiovascular disease -Lessons from knockout mice-
新藤隆行
2005, InvitedKruppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling
新藤隆行
2003, InvitedResearch Themes
- Development of new therapy using animal models of atherosclerosis, hypertension, heart failure, renal failure and liver failure.
- Pathophysiological roles of vasoactive peptides and their receptor system.
- Regenerative medicine of blood vessel.
- Generation of novel genetically engineerd mice.
- Development of novel technique for genome editing
Industrial Property Rights
- RAMP2を標的とする血管構造の安定化剤及び血管新生剤, EP1900374, Patent right
新藤隆行 - RAMP2を標的とする血管構造の安定化剤及び血管新生剤, US 9,072,777B2, Patent right
新藤隆行 - 代謝症候群の治療もしくは予防剤、検査方法、検査薬、及び代謝症候群の治療薬の候補化合物のスクリーニング方法, CNZL200880117473.2, Patent right
新藤隆行 - 代謝症候群の治療もしくは予防剤、検査方法、検査薬、及び代謝症候群の治療薬の候補化合物のスクリーニング方法, US 8,858,915 B2, Patent right
新藤隆行 - 代謝症候群の治療もしくは予防剤、検査方法、検査薬、及び代謝症候群の治療薬の候補化合物のスクリーニング方法, EP2221065, Patent right
- RAMP2を標的とする血管構造の安定化剤及び血管新生剤, 4993606, 304422, Patent right
新藤隆行 - 代謝症候群の治療もしくは予防剤、検査方法、検査薬、及び代謝症候群の治療薬の候補化合物のスクリーニング方法, 5099856, 071212 , Patent right
新藤隆行