Doctor of Medicine, 筑波大学大学院

Physiology, Physiology

Clinical pharmacy, Research Fieldmolecular pathophysiology

1992, 筑波大学

Increased expression of CD38 on endothelial cells in SARS-CoV-2 infection in cynomolgus macaque.
Nguyen, C.T., Nakayama, M., Ishigaki, H., Kitagawa, Y., Kakino, A., Ohno, M., Shingai, M., Suzuki, Y., Sawamura, T., Kida, H. and Ito, Y.
Virology, 594, 110052, 2024, Refereed

"Affimer" synthetic protein scaffolds block oxidized LDL binding to the LOX-1 scavenger receptor and inhibit ERK1/2 activation.
Roper, B.W.R., Tiede, C., Abdul-Zani, I., Cuthbert, G.A., Jade, D., Al-Aufi, A., Critchley, W.R., Saikia, Q., Homer-Vanniasinkam, S., Sawamura, T., McPherson, M.J., Harrison, M.A., Tomlinson, D.C. and Ponnambalam, S.
J Biol Chem, 299, 105325, 2023, Refereed

Editorial: Implications of lipids and modified lipoproteins in atherogenesis: from mechanisms towards novel diagnostic and therapeutic targets.
Kraler, S., Sawamura, T., Harn, G.Y., Chen, C.H. and Akhmedov, A.
Front Cardiovasc Med, 10, 1245716, 2023, Refereed

Placenta-derived extracellular vesicles from preeclamptic pregnancies impair vascular endothelial function via lectin-like oxidized LDL receptor-1.
Villalobos-Labra, R., Liu, R., Spaans, F., Saez, T., Semeria Maitret, T., Quon, A., Sawamura, T., Cooke, C.M. and Davidge, S.T.
Hypertension, 80, 2226-2238, 2023, Refereed

LOX-1 deficiency increases ruptured abdominal aortic aneurysm via thinning of adventitial collagen.
Takahashi, K., Aono, J., Nakao, Y., Hamaguchi, M., Suehiro, C., Kurata, M., Sakaue, T., Kakino, A., Sawamura, T., Inoue, K., Ikeda, S., Suzuki, J. and Yamaguchi, O.
Hypertens Res, 46, 63-74, 2023, Refereed

NanoSPECT imaging reveals the uptake of 123I-labeled oxidized low-density lipoprotein in the brown adipose tissue of mice via CD36.
Hosomi, K., Kawashima, H., Nakano, A., Kakino, A., Okamatsu-Ogura, Y., Yamashita, Y., Sasaoka, M., Masuda, D., Yamashita, S., Chen, C.H., Yuzuriha, S., Hosoda, H., Iida, H. and Sawamura, T.
Cardiovasc Res, 119, 1008-1020, 2023, Refereed

Lectin-like oxidized low-density lipoprotein receptor-1 attenuates pneumonia-induced lung injury.
Korkmaz, F.T., Shenoy, A.T., Symer, E., Baird, L.A., Odom, C.V., Arafa, E., Dimbo, E.L., Na, E., Molina-Arocho, W., Brudner, M., Standiford, T.J., Mehta, J.L., Sawamura, T., Jones, M.R., Mizgerd, J.P., Traber, K.T. and Quinton, L.J.
JCI Insight, 7, e149955, 2022, Refereed

Serum modified high-density lipoprotein and risk of atherosclerotic cardiovascular disease in a Japanese community-based nested case-control study.
Sata, M., Kakino, A., Hirata, A., Iida, M., Usami, Y., Harada, S., Fujita, Y., Kohsaka, S., Izawa, Y., Sawano, M., Oki, K., Sugiyama, D., Takahashi, S., Takebayashi, T., Sawamura, T. and Okamura, T.
Eur J Prev Cardiol, 29, e193-e195, 2022

Abnormal blood coagulation and kidney damage in aged hamsters infected with severe acute respiratory syndrome coronavirus 2.
Ohno, M., Sasaki, M., Orba, Y., Sekiya, T., Masum, M.A., Ichii, O., Sawamura, T., Kakino, A., Suzuki, Y., Kida, H., Sawa, H. and Shingai, M.
Viruses, 13, 2137, 2021

Lectin-like oxidized LDL receptor-1 (LOX-1): A crucial driver of atherosclerotic cardiovascular disease.
Akhmedov, A., Sawamura, T., Chen, C.H., Kraler, S., Vdovenko, D. and Lüscher, T.F.
Eur Heart J, 42, 1797-1807, 2021

Autoimmune rheumatic diseases: An update on the role of atherogenic electronegative LDL and potential therapeutic strategies.
Chen, D.Y., Sawamura, T., Dixon, R.A.F., Sanchez-Quesada, J.L. and Chen, C.H.
J Clin Med, 10, 1992, 2021

Critical role of oxidized LDL receptor-1 in intravascular thrombosis in a severe influenza mouse model.
Ohno, M., Kakino, A., Sekiya, T., Nomura, N., Shingai, M., Sawamura, T. and Kida, H.
Sci Rep, 11, 15675, 2021

Adiponectin forms a complex with atherogenic LDL and inhibits its downstream effects.
Kakino, A., Fujita, Y., Ke, L.Y., Chan, H.C., Tsai, M.H., Dai, C.Y., Chen, C.H. and Sawamura, T.
J Lipid Res, 62, 100001, 2021

The endocytosis of oxidized LDL via the activation of the angiotensin II type 1 receptor.
Takahashi, T., Huang, Y., Yamamoto, K., Hamano, G., Kakino, A., Kang, F., Imaizumi, Y., Takeshita, H., Nozato, Y., Nozato, S., Yokoyama, S., Nagasawa, M., Kawai, T., Takeda, T., Fujimoto, T., Hongyo, K., Nakagami, F., Akasaka, H., Takami, Y., Takeya, Y., Sugimoto, K., Gaisano, H.Y., Sawamura, T. and Rakugi, H
ISCIENCE, 24, 102076, 2021

Quantitative and qualitative lipid improvement with chronic hepatitis C virus eradication using with direct-acting antivirals.
Joshita, S., Yamashita, Y., Okamoto, T., Usami, Y., Sugiura, A., Yamazaki, T., Kakino, A., Ota, M., Sawamura, T. and Umemura, T.
Hepatol Res, 51, 758-766, 2021

RAGE ligands stimulate angiotensin II type I receptor (AT1) via RAGE/AT1 complex on the cell membrane.
Yokoyama, S., Kawai, T., Yamamoto, K., Yibin, H., Yamamoto, H., Kakino, A., Takeshita, H., Nozato, Y., Fujimoto, T., Hongyo, K., Takahashi, T., Nakagami, F., Akasaka, H., Takami, Y., Takeya, Y., Sugimoto, K., Sawamura, T. and Rakugi, H.
Sci Rep, 11, 5759, 2021

The relationship between serum levels of LOX-1 ligand containing ApoAI as a novel marker of dysfunctional HDL and coronary artery calcification in middle-aged Japanese men.
Hirata, A., Kakino, A., Okamura, T., Usami, Y., Fujita, Y., Kadota, A., Fujiyoshi, A., Hisamatsu, T., Kondo, K., Segawa, H., Sawamura, T., Miura, K., Ueshima, H. and Group, S.R.
Atherosclerosis, 313, 20-25, 2020

Role of lectin-like oxidized LDL receptor-1 and syncytiotrophoblast extracellular vesicles in the vascular reactivity of mouse uterine arteries during pregnancy.
Spaans, F., Quon, A., Kirschenman, R., Morton, J.S., Sawamura, T., Tannetta, D.S., Sargent, I.L. and Davidge, S.T.
Sci Rep, 10, 6046, 2020

High-cholesterol diet during pregnancy induces maternal vascular dysfunction in mice: Potential role for oxidized LDL-induced LOX-1 and AT1 receptor activation.
Sáez, T., Spaans, F., Kirschenman, R., Sawamura, T. and Davidge, S.T.
Clin Sci (Lond), 134, 2295-2313, 2020

Atherogenic L5 LDL induces cardiomyocyte apoptosis and inhibits K ATP channels through CaMKII activation
Ma, Y., Cheng, N., Sun, J., Lu, J.X., Abbasi, S., Wu, G., Lee, A.S., Sawamura, T., Cheng, J., Chen, C.H. and Xi Y.
Lipids Health Dis, 19, 189, 2020

LOX-1 deletion has protective effects on stroke in the genetic background of stroke-prone spontaneously hypertensive rat.
Liang, Y.Q., Kakino, A., Matsuzaka, Y., Mashimo, T., Isono, M., Akamatsu, T., Shimizu-Furusawa, H., Tajima, M., Kaneko, T., Li, L., Takeuchi, F., Sawamura, T. and Kato, N.
Stroke, 51, 1835-1843, 2020

LDL uptake-dependent phosphatidylethanolamine translocation to the cell surface promotes fusion of osteoclast-like cells.
Kitano, V.J.F., Ohyama, Y., Hayashida, C., Ito, J., Okayasu, M., Sato, T., Ogasawara, T., Tsujita, M., Kakino, A., Shimada, J., Sawamura, T. and Hakeda, Y.
J Cell Sci, 133, jcs243840, 2020

Detection of a high ratio of soluble to membrane-bound LOX-1 in aspirated coronary thrombi from patients with ST-segment-elevation myocardial infarction.
Lee, A.S., Wang, Y.C., Chang, S.S., Lo, P.H., Chang, C.M., Lu, J., Burns, A.R., Chen, C.H., Kakino, A., Sawamura, T. and Chang, K.C.
J Am Heart Assoc, 9, e014008, 2020

Oxidized low-density lipoproteins induce tissue factor expression in T-lymphocytes via activation of lectin-like oxidized low-density lipoprotein receptor-1.
Cimmino, G., Cirillo, P., Conte, S., Pellegrino, G., Barra, G., Maresca, L., Morello, A., Cali, G., Loffredo, F., Palma, R., Arena, G., Sawamura, T., Ambrosio, G. and Golino, P.
Cardiovasc Res, 116, 1125-1135, 2020

Targeting LOX-1 in atherosclerosis and vasculopathy: current knowledge and future perspectives.
Tian, K., Ogura, S., Little, P.J., Xu, S.W. and Sawamura, T.
Ann N Y Acad Sci, 1443, 34-53, 2019

A novel cell-free, non-fluorescent method to measure LOX-1- binding activity corresponding to the functional activity of HDL.
Kakino, A., Usami, Y., Horiuchi, S., Fujita, Y., Kotani, K., Chen, C.H., Okamura, T. and Sawamura, T.
J Atheroscler Thromb, 26, 947-958, 2019

Dysfunctional high density lipoprotein failed to rescue the function of oxidized low density lipoprotein-treated endothelial progenitor cells: a novel index for the prediction of HDL functionality.
Shih, C.M., Lin, F.Y., Yeh, J.S., Lin, Y.W., Loh, S.H., Tsao, N.W., Nakagami, H., Morishita, R., Sawamura, T., Li, C.Y., Lin, C.Y. and Huang, C.Y.
Transl Res, 205, 17-32, 2019

Alterations in vascular function by syncytiotrophoblast extracellular vesicles via lectin-like oxidized low-density lipoprotein receptor-1 in mouse uterine arteries.
Spaans, F., Quon, A., Rowe, S.R., Morton, J.S., Kirschenman, R., Sawamura, T., Tannetta, D.S., Sargent, I.L. and Davidge, S.T.
Clin Sci (Lond), 132, 2369-2381, 2018

Smoking cessation reduces the lectin-like low-density lipoprotein receptor index, an independent cardiovascular risk marker of vascular inflammation.
Komiyama, M., Wada, H., Ono, K., Yamakage, H., Satoh-Asahara, N., Shimada, S., Akao, M., Morimoto, T., Shimatsu, A., Takahashi, Y., Sawamura, T. and Hasegawa, K.
Heart Vessels, 33, 9-16, 2018

123I-labeled oxLDL is widely distributed throughout the whole body in mice.
Nakano, A., Kawashima, H., Miyake, Y., Zeniya, T., Yamamoto, A., Koshino, K., Temma, T., Fukuda, T., Fujita, Y., Kakino, A., Kanaya, S., Sawamura, T. and Iida, H.
Nucl Med Mol Imaging, 52, 144-153, 2018

Ecrg4 peptide is the ligand of multiple scavenger receptors.
Moriguchi, T., Takeda, S., Iwashita, S., Enomoto, K., Sawamura, T., Koshimizu, U. and Kondo, T.
Sci Rep, 8, 4048, 2018

Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo.
Wang, Y.C., Lee, A.S., Lu, L.S., Ke, L.Y., Chen, W.Y., Dong, J.W., Lu, J., Chen, Z., Chu, C.S., Chan, H.C., Kuzan, T.Y., Tsai, M.H., Hsu, W.L., Dixon, R.A.F., Sawamura, T., Chang, K.C. and Chen, C.H.
Aging Cell, 17, e12792, 2018

L5: an LDL fraction in which pathogenic activity of LDL is concentrated.
Sawamura, T., Fujita, Y., Horiuchi, S. and Kakino, A.
Trends Cardiovasc Med, 27, 247-248, 2017

LOX-1 in ischemic stroke.
Sawamura, T., Fujita, Y., Horiuchi, S. and Kakino, A.
J Atheroscler Thromb, 24, 566-568, 2017

A consensus definitive classification of scavenger receptors and their roles in health and disease.
PrabhuDas, M.R., Baldwin, C.L., Bollyky, P.L., Bowdish, DM.E., Drickamer, K., Febbraio, M., Herz, J., Kobzik, L., Krieger, M., Loike, J., McVicker, B., Means, T.K., Moestrup, S.K., Post, S.R., Sawamura, T., Silverstein, S., Speth, R.C., Telfer, J.C., Thiele, G.M., Wang, X.Y., Wright, S.D. and El Khoury, J.
J Immunol, 198, 3775-3789, 2017

Syncytiotrophoblast extracellular vesicles impair rat uterine vascular function via the lectin-like oxidized LDL receptor-1.
Spaans, F., Kao, C.K., Morton, J.S., Quon, A.L., Sawamura, T., Tannetta, D.S., Sargent, I.L. and Davidge, S.T.
PLOS ONE, 12, e0180364, 2017

Electronegative low-density lipoprotein L5 induces adipose tissue inflammation associated with metabolic syndrome.
Ke, L.Y., Chan, H.C., Chan, H.C., Kalu, F.C.U., Lee, H.C., Lin, I.L., Jhuo, S.J., Lai, W.T., Tsao, C.R., Sawamura, T., Dixon, R.A., Chen, C.H., Chu, C.S. and Shin, S.J.
J Clin Endocrinol Metab, 102, 4615-4625, 2017

Interplay between CRP, atherogenic LDL, and LOX-1 and its potential role in the pathogenesis of atherosclerosis.
Stancel, N., Chen, C.C., Ke, L.Y., Chu, C.S., Lu, J., Sawamura, T. and Chen, C.H.
Clin Chem, 62, 320-327, 2016

Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation.
Shen, M.Y., Chen, F.Y., Hsu, J.F., Fu, R.H., Chang, C.M., Chang, C.T., Liu, C.H., Wu, J.R., Lee, A.S., Chan, H.C., Sheu, J.R., Lin, S.Z., Shyu, W.C., Sawamura, T., Chang, K.C., Hsu, C.Y. and Chen, C.H.
BLOOD, 127, 1336-1345, 2016

Serum level of LOX-1 ligand containing ApoB is associated with increased carotid intima-media thickness in Japanese community-dwelling men, especially those with hypercholesterolemiaLOX-1 ligand and IMT in Japanese.
Okamura, T., Miura, K., Sawamura, T., Kadota, A., Hisamatsu, T., Fujiyoshi, A., Miyamatsu, N., Takashima, N., Miyagawa, N., Kadowaki, T., Ohkubo, T., Murakami, Y., Nakamura, Y., Ueshima, H. and Group, S.R.
J Clin Lipidol, 10, 172-180, 2016

Lectin-like oxidized low density lipoprotein receptor 1-deficient mice show resistance to instability-induced osteoarthritis.
Hashimoto, K., Mori, S., Oda, Y., Nakano, A., Sawamura, T. and Akagi, M.
Scand J Rheumatol, 45, 412-422, 2016

High levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 in acute stroke: an age- and sex-matched cross-sectional study.
Yokota, C., Sawamura, T., Watanabe, M., Kokubo, Y., Fujita, Y., Kakino, A., Nakai, M., Toyoda, K., Miyamoto, Y. and Minematsu, K.
J Atheroscler Thromb, 23, 1222-1226, 2016

Deletion of LOX-1 protects against heart failure induced by doxorubicin.
Yokoyama, C., Aoyama, T., Ido, T., Kakino, A., Shiraki, T., Tanaka, T., Nishigaki, K., Hasegawa, A., Fujita, Y., Sawamura, T. and Minatoguchi, S.
PLOS ONE, 11, e0154994, 2016

Lectin-like oxidized low-density lipoprotein receptor (LOX-1) in sickle cell disease vasculopathy.
Chen, M., Qiu, H., Lin, X., Nam, D., Ogbu-Nwobodo, L., Archibald, H., Joslin, A., Wun, T., Sawamura, T. and Green, R.
Blood Cells Mol Dis, 60, 44-48, 2016

Developmental endothelial locus-1 (Del-1) inhibits oxidized low-density lipoprotein activity by direct binding, and its overexpression attenuates atherogenesis in mice.
Kakino, A., Fujita, Y., Nakano, A., Horiuchi, S. and Sawamura, T.
Circ J, 80, 2541-2549, 2016

Electronegative low-density lipoprotein increases coronary artery disease risk in uremia patients on maintenance hemodialysis.
Chang, C.T., Wang, G.J., Kuo, C.C., Hsieh, J.Y., Lee, A.S., Chang, C.M., Wang, C.C., Shen, M.Y., Huang, C.C., Sawamura, T., Yang, C.Y., Stancel, N. and Chen, C.H.
Medicine (Baltimore), 95, e2265, 2016

Increased LDL electronegativity in chronic kidney disease disrupts calcium homeostasis resulting in cardiac dysfunction.
Chang, K.C., Lee, A.S., Chen, W.Y., Lin, Y.N., Hsu, J.F., Chan, H.C., Chang, C.M., Chang, S.S., Pan, C.C., Sawamura, T., Chang, C.T., Su, M.J. and Chen, C.H.
J Mol Cell, 84, 36-44, 2015

Effect of sodium tanshinone IIA sulfonate treatment in a rat model of preeclampsia.
Morton, J.S., Quon, A., Cheung, P.Y., Sawamura, T. and Davidge, S.T.
Am J Physiol Regul Integr Comp Physiol, 308, R163-172, 2015

Lectin-like oxidized low-density lipoprotein receptor-1 abrogation causes resistance to inflammatory bone destruction in mice, despite promoting osteoclastogenesis in the steady state.
Nakayachi, M., Ito, J., Hayashida, C., Ohyama, Y., Kakino, A., Okayasu, M., Sato, T., Ogasawara, T., Kaneda, T., Suda, N., Sawamura, T. and Hakeda, Y.
BONE, 75, 170-182, 2015

Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptor.
Yamamoto, K., Kakino, A., Takeshita, H., Hayashi, N., Li, L., Nakano, A., Hanasaki-Yamamoto, H., Fujita, Y., Imaizumi, Y., Toyama-Yokoyama, S., Nakama, C., Kawai, T., Takeda, M., Hongyo, K., Oguro, R., Maekawa, Y., Itoh, N., Takami, Y., Onishi, M., Takeya, Y., Sugimoto, K., Kamide, K., Nakagami, H., Ohishi, M., Kurtz, T.W., Sawamura, T. and Rakugi, H.
FASEB J, 29, 3342-3356, 2015

The relationship between lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B and the cardio-ankle vascular index in healthy community inhabitants: The KOBE Study.
Sugiyama, D., Higashiyama, A., Wakabayashi, I., Kubota, Y., Adachi, Y., Hayashibe, A., Kawamura, K., Kuwabara, K., Nishimura, K., Kadota, A., Nishida, Y., Hirata, T., Imano, H., Miyamatsu, N., Miyamoto, Y., Sawamura, T. and Okamura, T.
J Atheroscler Thromb, 22, 499-508, 2015

LOX-1 in atherosclerotic disease.
Sawamura, T., Wakabayashi, I. and Okamura, T.
Clin Chim Acta, 440, 157-163, 2015

Cross-talk between LOX-1 and PCSK9 in vascular tissues.
Ding, Z., Liu, S., Wang, X., Deng, X., Fan, Y., Shahanawaz, J., Shmookler Reis, R.J., Varughese, K.I., Sawamura, T. and Mehta, J.L.
Cardiovasc Res, 107, 556-567, 2015

Human serum amyloid A3 (SAA3) protein, expressed as a fusion protein with SAA2, binds the oxidized low density lipoprotein receptor.
Tomita, T., Ieguchi, K., Sawamura, T. and Maru, Y.
PLOS ONE, 10, e0118835, 2015

High-salt in addition to high-fat diet may enhance inflammation and fibrosis in liver steatosis induced by oxidative stress and dyslipidemia in mice.
Uetake, Y., Ikeda, H., Irie, R., Tejima, K., Matsui, H., Ogura, S., Wang, H., Mu, S., Hirohama, D., Ando, K., Sawamura, T., Yatomi, Y., Fujita, T. and Shimosawa, T.
Lipids Health Dis, 14, 6, 2015

The biphasic effects of oxidized-low density lipoprotein on the vasculogenic function of endothelial progenitor cells.
Lin, F.Y., Tsao, N.W., Shih, C.M., Lin, Y.W., Yeh, J.S., Chen, J.W., Nakagami, H., Morishita, R., Sawamura, T. and Huang, C.Y.
PLOS ONE, 10, e0123971, 2015

Standardizing scavenger receptor nomenclature.
Prabhudas, M., Bowdish, D., Drickamer, K., Febbraio, M., Herz, J., Kobzik, L., Krieger, M., Loike, J., Means, T.K., Moestrup, S.K., Post, S., Sawamura, T., Silverstein, S., Wang, X.Y. and El Khoury, J.
J Immunol, 192, 1997-2006, 2014

Prevention of export of anoxia/reoxygenation injury from ischemic to nonischemic cardiomyocytes via inhibition of endocytosis.
Khaidakov, M., Mercanti, F., Wang, X., Ding, Z., Dai, Y., Romeo, F., Sawamura, T. and Mehta, J.L.
Am J Physiol Heart Circ Physiol, 306, H1700-1707, 2014

Pitavastatin decreases serum LOX-1 ligand levels and MT1-MMP expression in CD14-positive mononuclear cells in hypercholesterolemic patients.
Uzui, H., Hayashi, H., Nakae, I., Matsumoto, T., Uenishi, H., Hayasaki, H., Asaji, T., Matsui, S., Miwa, K., Lee, J.D., Tada, H., Sawamura, T. and Fujita, M.
Int J Cardiol, 176, 1230-1232, 2014

Significance of soluble lectin-like oxidized LDL receptor-1 levels in systemic and coronary circulation in acute coronary syndrome.
Misaka, T., Suzuki, S., Sakamoto, N., Yamaki, T., Sugimoto, K., Kunii, H., Nakazato, K., Saitoh, S., Sawamura, T., Ishibashi, T. and Takeishi, Y.
Biomed Res Int, 2014, 649185, 2014

LOX-1 plays an important role in ischemia-induced angiogenesis of limbs.
Shiraki, T., Aoyama, T., Yokoyama, C., Hayakawa, Y., Tanaka, T., Nishigaki, K., Sawamura, T. and Minatoguchi, S.
PLOS ONE, 9, e114542, 2014

Oxidized low density lipoprotein (LDL) affects hyaluronan synthesis in human aortic smooth muscle cells.
Viola, M., Bartolini, B., Vigetti, D., Karousou, E., Moretto, P., Deleonibus, S., Sawamura, T., Wight, T.N., Hascall, V.C., De Luca, G. and Passi, A.
J Biol Chem, 288, 29595-29603, 2013

Lectin-like oxidized low-density lipoprotein receptor-1 plays an important role in vascular inflammation in current smokers.
Takanabe-Mori, R., Ono, K., Wada, H., Takaya, T., Ura, S., Yamakage, H., Satoh-Asahara, N., Shimatsu, A., Takahashi, Y., Fujita, M., Fujita, Y., Sawamura, T. and Hasegawa, K.
J Atheroscler Thromb, 20, 585-590, 2013

LOX-1 ligands containing apolipoprotein B and carotid intima-media thickness in middle-aged community-dwelling US Caucasian and Japanese men.
Okamura, T., Sekikawa, A., Sawamura, T., Kadowaki, T., Barinas-Mitchell, E., Mackey, R.H., Kadota, A., Evans, R.W., Edmundowicz, D., Higashiyama, A., Nakamura, Y., Abbott, R.D., Miura, K., Fujiyoshi, A., Fujita, Y., Murakami, Y., Miyamatsu, N., Kakino, A., Maegawa, H., Murata, K., Horie, M., Mitsunami, K., Kashiwagi, A., Kuller, L.H., Ueshima, H. and Group, E.J.S.
Atherosclerosis, 229, 240-245, 2013

Inhibition of lectin-like oxidized low-density lipoprotein-1 receptor protects against plasma-mediated vascular dysfunction associated with pre-eclampsia.
English, F.A., McCarthy, F.P., McSweeney, C.L., Quon, A.L., Morton, J.S., Sawamura, T., Davidge, S.T. and Kenny, L.C.
Am J Hypertens, 26, 279-286, 2013

Highly electronegative LDL from patients with ST-elevation myocardial infarction triggers platelet activation and aggregation.
Chan, H.C., Ke, L.Y., Chu, C.S., Lee, A.S., Shen, M.Y., Cruz, M.A., Hsu, J.F., Cheng, K.H., Chan, H.C., Lu, J., Lai, W.T., Sawamura, T., Sheu, S.H., Yen, J.H. and Chen, C.H.
BLOOD, 122, 3632-3641, 2013

Small dense low-density lipoproteins cholesterol can predict incident cardiovascular disease in an urban Japanese cohort: the Suita study.
Arai, H., Kokubo, Y., Watanabe, M., Sawamura, T., Ito, Y., Minagawa, A., Okamura, T. and Miyamato, Y.
J Atheroscler Thromb, 20, 195-203, 2013

Electronegative low-density lipoprotein increases C-reactive protein expression in vascular endothelial cells through the LOX-1 receptor.
Chu, C.S., Wang, Y.C., Lu, L.S., Walton, B., Yilmaz, H.R., Huang, R.Y., Sawamura, T., Dixon, R.A., Lai, W.T., Chen, C.H. and Lu, J.
PLOS ONE, 8, e70533, 2013

LOX-1: a multiligand receptor at the crossroads of response to danger signals.
Sawamura, T., Kakino, A. and Fujita, Y.
Curr Opin Lipidol, 23, 439-445, 2012

Dietary cholesterol oxidation products accelerate plaque destabilization and rupture associated with monocyte infiltration/activation via the MCP-1-CCR2 pathway in mouse brachiocephalic arteries: therapeutic effects of ezetimibe.
Sato, K., Nakano, K., Katsuki, S., Matoba, T., Osada, K., Sawamura, T., Sunagawa, K. and Egashira, K.
J Atheroscler Thromb, 19, 986-998, 2012

Lectin-like oxidized low-density lipoprotein 1 receptor in a reduced uteroplacental perfusion pressure rat model of preeclampsia.
Morton, J.S., Abdalvand, A., Jiang, Y., Sawamura, T., Uwiera, R.R. and Davidge, S.T.
Hypertension, 59, 1014-1020, 2012

Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritis.
Ishikawa, M., Ito, H., Akiyoshi, M., Kume, N., Yoshitomi, H., Mitsuoka, H., Tanida, S., Murata, K., Shibuya, H., Kasahara, T., Kakino, A., Fujita, Y., Sawamura, T., Yasuda, T. and Nakamura, T.
Arthritis Rheum, 64, 1024-1034, 2012

LOX-1: a new target for therapy for cardiovascular diseases.
Mehta, J. L., Khaidakov, M., Hermonat, P. L., Mitra, S., Wang, X., Novelli, G., and Sawamura, T.
Cardiovasc Drugs Ther, 25, 495-500, 2011

The discovery of LOX-1, its ligands and clinical significance.
Yoshimoto, R., Fujita, Y., Kakino, A., Iwamoto, S., Takaya, T. and Sawamura, T.
Cardiovasc Drugs Ther, 25, 379-391, 2011

Associations of atherosclerotic risk factors with oxidized low-density lipoprotein evaluated by LOX-1 ligand activity in healthy men.
Uchida, K., Suehiro, A., Nakanishi, M., Sawamura, T. and Wakabayashi, I.
Clin Chim Acta, 412, 1643-1647, 2011

Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox.
Nishizuka, T., Fujita, Y., Sato, Y., Nakano, A., Kakino, A., Ohshima, S., Kanda, T., Yoshimoto, R. and Sawamura, T.
Proc Jpn Acad Ser B Phys Biol Sci, 87, 104-113, 2011

An alternative protein standard to measure activity of LOX-1 ligand containing apoB (LAB) - utilization of anti-LOX-1 single- chain antibody fused to apoB fragment.
Iwamoto, S., Fujita, Y., Kakino, A., Yanagida, K., Matsuda, H., Yoshimoto, R. and Sawamura, T.
J Atheroscler Thromb, 18, 818-828, 2011

Lectin-like oxidized LDL receptor 1 is involved in CRP-mediated complement activation.
Fujita, Y., Yamaguchi, S., Kakino, A., Iwamoto, S., Yoshimoto, R. and Sawamura, T.
Clin Chem, 57, 1398-1405, 2011

LOX-1 deletion improves neutrophil responses, enhances bacterial clearance, and reduces lung injury in a murine polymicrobial sepsis model.
Wu, Z., Sawamura, T., Kurdowska, A.K., Ji, H.L., Idell, S. and Fu, J.
Infect Immun, 79, 2865-2870, 2011

Aldosterone augments LOX-1-mediated low-density lipoprotein uptake in human umbilical artery endothelial cells.
Taye, A., Sawamura, T. and Morawietz, H.
Pharmacol Rep, 62, 311-318, 2010

Lectin-like oxidized low-density lipoprotein receptor-1 is required for the adipose tissue expression of proinflammatory cytokines in high-fat diet-induced obese mice.
Takanabe-Mori, R., Ono, K., Sowa, N., Wada, H., Takaya, T., Horie, T., Satoh-Asahara, N., Shimatsu, A., Fujita, M., Sawamura, T. and Hasegawa, K.
Biochem Biophys Res Commun, 398, 576-580, 2010

Dihydrotestosterone suppresses foam cell formation and attenuates atherosclerosis development.
Qiu, Y., Yanase, T., Hu, H., Tanaka, T., Nishi, Y., Liu, M., Sueishi, K., Sawamura, T. and Nawata, H.
Endocrinology, 151, 3307-3316, 2010

High efficiency CD91- and LOX-1-mediated re-presentation of gp96-chaperoned peptides by MHC II molecules.
Matsutake, T., Sawamura, T. and Srivastava, P.K.
Cancer Immun, 10, 7, 2010

Induction of hypertrophic chondrocyte-like phenotypes by oxidized LDL in cultured bovine articular chondrocytes through increase in oxidative stress.
Kishimoto, H., Akagi, M., Zushi, S., Teramura, T., Onodera, Y., Sawamura, T. and Hamanishi, C.
Osteoarthritis Cartilage, 18, 1284-1290, 2010

Pitavastatin reduces lectin-like oxidized low-density lipoprotein receptor-1 ligands in hypercholesterolemic humans.
Matsumoto, T., Fujita, M., Sawamura, T., Kakino, A., Sato, Y., Fujita, Y., Matsuda, H., Nakanishi, M., Uchida, K., Nakae, I., Kanda, H., Yoshida, A., Miwa, K., Hayashi, H., Mitsunami, K. and Horie, M.
Lipids, 45, 329-335, 2010

LOX index, a novel predictive biochemical marker for coronary heart disease and stroke.
Inoue, N., Okamura, T., Kokubo, Y., Fujita, Y., Sato, Y., Nakanishi, M., Yanagida, K., Kakino, A., Iwamoto, S., Watanabe, M., Ogura, S., Otsui, K., Matsuda, H., Uchida, K., Yoshimoto, R. and Sawamura, T.
Clin Chem, 56, 550-558, 2010

Left ventricular expression of lectin-like oxidized low-density lipoprotein receptor-1 in failing rat hearts.
Takaya, T., Wada, H., Morimoto, T., Sunagawa, Y., Kawamura, T., Takanabe-Mori, R., Shimatsu, A., Fujita, Y., Sato, Y., Fujita, M., Kimura, T., Sawamura, T. and Hasegawa, K.
Circ J, 74, 723-729, 2010

C-reactive protein uptake by macrophage cell line via class-A scavenger receptor.
Fujita, Y., Kakino, A., Harada-Shiba, M., Sato, Y., Otsui, K., Yoshimoto, R. and Sawamura, T.
Clin Chem, 56, 478-481, 2010

LOX-1 mediates vascular lipid retention under hypertensive state.
Nakano, A., Inoue, N., Sato, Y., Nishimichi, N., Takikawa, K., Fujita, Y., Kakino, A., Otsui, K., Yamaguchi, S., Matsuda, H. and Sawamura, T.
J Hypertens, 28, 1273-1280, 2010

New Idol of cholesterol reduction?
Sawamura,T.
Clin Chem, 55, 2082-2084, 2009

LOX-1: the multifunctional receptor underlying cardiovascular dysfunction.
Ogura, S., Kakino, A., Sato, Y., Fujita, Y., Iwamoto, S., Otsui, K., Yoshimoto, R. and Sawamura, T.
Circ J, 73, 1993-1999, 2009

Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apoptosis.
Lu, J., Yang, J.H., Burns, A.R., Chen, H.H., Tang, D., Walterscheid, J.P., Suzuki, S., Yang, C.Y., Sawamura, T. and Chen, C.H.
Circ Res, 104, 619-627, 2009

A novel gene silencer, pyrrole-imidazole polyamide targeting human lectin-like oxidized low-density lipoprotein receptor-1 gene improves endothelial cell function.
Ueno, T., Fukuda, N., Tsunemi, A., Yao, E.H., Matsuda, H., Tahira, K., Matsumoto, T., Matsumoto, K., Matsumoto, Y., Nagase, H., Sugiyama, H. and Sawamura, T.
J Hypertens, 27, 508-516, 2009

Oxidized LDL receptor LOX-1 binds to C-reactive protein and mediates its vascular effects.
Fujita, Y., Kakino, A., Nishimichi, N., Yamaguchi, S., Sato, Y., Machida, S., Cominacini, L., Delneste, Y., Matsuda, H. and Sawamura, T.
Clin Chem, 55, 285-294, 2009

Generation and characterization of chicken monoclonal antibodies against human LOX-1.
Iwamoto, S., Nishimichi, N., Tateishi, Y., Sato, Y., Horiuchi, H., Furusawa, S., Sawamura, T. and Matsuda, H.
MAbs, 1, 357-363, 2009

Induction of bovine articular chondrocyte senescence with oxidized low-density lipoprotein through lectin-like oxidized low-density lipoprotein receptor 1.
Zushi, S., Akagi, M., Kishimoto, H., Teramura, T., Sawamura, T. and Hamanishi, C.
Arthritis Rheum, 60, 3007-3016, 2009

Evidence for increased methylglyoxal in the vasculature of women with preeclampsia: role in upregulation of LOX-1 and arginase.
Sankaralingam, S., Xu, H., Jiang, Y., Sawamura, T. and Davidge, S.T.
Hypertension, 54, 897-904, 2009

Impaired vascular function in small resistance arteries of LOX-1 overexpressing mice on high-fat diet.
Eichhorn, B., Muller, G., Leuner, A., Sawamura, T., Ravens, U. and Morawietz, H.
Cardiovasc Res, 82, 493-502, 2009

Role of LOX-1 in monocyte adhesion-triggered redox, Akt/eNOS and Ca2+ signaling pathways in endothelial cells.
Sakamoto, N., Ishibashi, T., Sugimoto, K., Sawamura, T., Sakamoto, T., Inoue, N., Saitoh, S., Kamioka, M., Uekita, H., Ohkawara, H., Suzuki, K., Teramoto, T., Maruyama, Y. and Takeishi, Y.
J Cell Physiol, 220, 706-715, 2009

LOX-1-MT1-MMP axis is crucial for RhoA and Rac1 activation induced by oxidized low-density lipoprotein in endothelial cells.
Sugimoto, K., Ishibashi, T., Sawamura, T., Inoue, N., Kamioka, M., Uekita, H., Ohkawara, H., Sakamoto, T., Sakamoto, N., Okamoto, Y., Takuwa, Y., Kakino, A., Fujita, Y., Tanaka, T., Teramoto, T., Maruyama, Y. and Takeishi, Y.
Cardiovasc Res, 84, 127-136, 2009

LOX-1 augments oxLDL uptake by lysoPC-stimulated murine macrophages but is not required for oxLDL clearance from plasma.
Schaeffer, D.F., Riazy, M., Parhar, K.S., Chen, J.H., Duronio, V., Sawamura, T. and Steinbrecher, U.P.
J Lipid Res, 50, 1676-1684, 2009

Suppression of choroidal neovascularization in lectin-like oxidized low-density lipoprotein receptor type 1-deficient mice.
Inomata, Y., Fukushima, M., Hara, R., Takahashi, E., Honjo, M., Koga, T., Kawaji, T., Satoh, H., Takeya, M., Sawamura, T. and Tanihara, H.
Invest Ophthalmol Vis Sci, 50, 3970-3976, 2009

Oxidized LDL binding to LOX-1 enhances MCP-1 expression in cultured human articular chondrocytes.
Akagi, M., Ueda, A., Teramura, T., Kanata, S., Sawamura, T. and Hamanishi, C.
Osteoarthritis Cartilage, 17, 271-275, 2009

Increased lectin-like oxidized low-density lipoprotein receptor-1 expression in the maternal vasculature of women with preeclampsia: role for peroxynitrite.
Sankaralingam, S., Xu, Y., Sawamura, T. and Davidge, S.T.
Hypertension, 53, 270-277, 2009

LOX-1 dependent overexpression of immunoglobulins in cardiomyocytes in response to angiotensin II.
Kang, B.Y., Hu, C., Prayaga, S., Khaidakov, M., Sawamura, T., Seung, K.B. and Mehta, J.L.
Biochem Biophys Res Commun, 379, 395-399, 2009

LDL protein nitration: implication for LDL protein unfolding.
Hamilton, R.T., Asatryan, L., Nilsen, J.T., Isas, J.M., Gallaher, T.K., Sawamura, T. and Hsiai, T.K.
Arch Biochem Biophys, 479, 1-14, 2008

Expression and localization of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in murine and human placentas.
Satoh, H., Kiyota, E., Terasaki, Y., Sawamura, T., Takagi, K., Mizuta, H. and Takeya, M.
J Histochem Cytochem, 56, 773-784, 2008

Importance of forkhead transcription factor Fkhl18 for development of testicular vasculature.
Sato, Y., Baba, T., Zubair, M., Miyabayashi, K., Toyama, Y., Maekawa, M., Owaki, A., Mizusaki, H., Sawamura, T., Toshimori, K., Morohashi, K. and Katoh-Fukui, Y.
Mol Reprod Dev, 75, 1361-1371, 2008

Modulation of angiotensin II-mediated hypertension and cardiac remodeling by lectin-like oxidized low-density lipoprotein receptor-1 deletion.
Hu, C., Dandapat, A., Sun, L., Marwali, M.R., Inoue, N., Sugawara, F., Inoue, K., Kawase, Y., Jishage, K., Suzuki, H., Hermonat, P.L., Sawamura, T. and Mehta, J.L.
Hypertension, 52, 556-562, 2008

LOX-1 deletion decreases collagen accumulation in atherosclerotic plaque in low-density lipoprotein receptor knockout mice fed a high-cholesterol diet.
Hu, C., Dandapat, A., Sun, L., Chen, J., Marwali, M.R., Romeo, F., Sawamura, T. and Mehta, J.L.
Cardiovasc Res, 79, 287-293, 2008

Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis.
Ishigaki, Y., Katagiri, H., Gao, J., Yamada, T., Imai, J., Uno, K., Hasegawa, Y., Kaneko, K., Ogihara, T., Ishihara, H., Sato, Y., Takikawa, K., Nishimichi, N., Matsuda, H., Sawamura, T. and Oka, Y.
Circulation, 118, 75-83, 2008

Novel gene silencer pyrrole-imidazole polyamide targeting lectin-like oxidized low-density lipoprotein receptor-1 attenuates restenosis of the artery after injury.
Yao, E.H., Fukuda, N., Ueno, T., Matsuda, H., Matsumoto, K., Nagase, H., Matsumoto, Y., Takasaka, A., Serie, K., Sugiyama, H. and Sawamura, T.
Hypertension, 52, 86-92, 2008

Essential role of NOXA1 in generation of reactive oxygen species induced by oxidized low-density lipoprotein in human vascular endothelial cells.
Honjo, T., Otsui, K., Shiraki, R., Kawashima, S., Sawamura, T., Yokoyama, M. and Inoue, N.
Endothelium, 15, 137-141, 2008

Determination of LOX-1-ligand activity in mouse plasma with a chicken monoclonal antibody for ApoB.
Sato, Y., Nishimichi, N., Nakano, A., Takikawa, K., Inoue, N., Matsuda, H. and Sawamura, T.
Atherosclerosis, 200, 303-309, 2008

Electronegative LDL circulating in smokers impairs endothelial progenitor cell differentiation by inhibiting Akt phosphorylation via LOX-1.
Tang, D., Lu, J., Walterscheid, J.P., Chen, H.H., Engler, D.A., Sawamura, T., Chang, P.Y., Safi, H.J., Yang, C.Y. and Chen, C.H.
J Lipid Res, 49, 33-47, 2008

LOX-1 abrogation reduces myocardial ischemia-reperfusion injury in mice.
Hu, C., Chen, J., Dandapat, A., Fujita, Y., Inoue, N., Kawase, Y., Jishage, K., Suzuki, H., Li, D., Hermonat, P.L., Sawamura, T. and Mehta, J.L.
J Mol Cell Cardiol, 44, 76-83, 2008

Lectin-like oxidized LDL receptor-1 as extracellular chaperone receptor: Its versatile functions and human diseases.
Inoue, N. and Sawamura, T.
Methods, 43, 218-222, 2007

LOX-1 deletion alters signals of myocardial remodeling immediately after ischemia-reperfusion.
Hu, C., Dandapat, A., Chen, J., Fujita, Y., Inoue, N., Kawase, Y., Jishage, K., Suzuki, H., Sawamura, T. and Mehta, J.L.
Cardiovasc Res, 76, 292-302, 2007

Modulation of ADP-induced platelet activation by aspirin and pravastatin: role of lectin-like oxidized low-density lipoprotein receptor-1, nitric oxide, oxidative stress, and inside-out integrin signaling.
Marwali, M.R., Hu, C.P., Mohandas, B., Dandapat, A., Deonikar, P., Chen, J., Cawich, I., Sawamura, T., Kavdia, M. and Mehta, J.L.
J Pharmacol Exp Ther, 322, 1324-1332, 2007

Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol diet.
Mehta, J.L., Sanada, N., Hu, C.P., Chen, J., Dandapat, A., Sugawara, F., Satoh, H., Inoue, K., Kawase, Y., Jishage, K., Suzuki, H., Takeya, M., Schnackenberg, L., Beger, R., Hermonat, P.L., Thomas, M. and Sawamura, T.
Circ Res, 100, 1634-1642, 2007

Possible involvement of the oxidized low-density lipoprotein/lectin-like oxidized low-density lipoprotein receptor-1 system in pathogenesis and progression of human osteoarthritis.
Akagi, M., Kanata, S., Mori, S., Itabe, H., Sawamura, T. and Hamanishi, C.
Osteoarthritis Cartilage, 15, 281-290, 2007

Endothelin and endothelial dysfunction.
Masaki,T. and Sawamura,T.
Proc Jpn Acad Ser B Phys Biol Sci, 82, 17-24, 2006

Antioxidants suppress plasma levels of lectinlike oxidized low-density lipoprotein receptor-ligands and reduce atherosclerosis in watanabe heritable hyperlipidemic rabbits.
Oka, K., Yasuhara, M., Suzumura, K., Tanaka, K. and Sawamura, T.
J Cardiovasc Pharmacol, 48, 177-183, 2006

Low-density lipoprotein oxidized to various degrees activates ERK1/2 through LOX-1.
Tanigawa, H., Miura, S., Zhang, B., Uehara, Y., Matsuo, Y., Fujino, M., Sawamura, T. and Saku, K.
Atherosclerosis, 188, 245-250, 2006

Oxidized LDL binding to LOX-1 upregulates VEGF expression in cultured bovine chondrocytes through activation of PPAR-gamma.
Kanata, S., Akagi, M., Nishimura, S., Hayakawa, S., Yoshida, K., Sawamura, T., Munakata, H. and Hamanishi, C.
Biochem Biophys Res Commun, 348, 1003-1010, 2006

Cyclic tensile stretch load and oxidized low density lipoprotein synergistically induce lectin-like oxidized ldl receptor-1 in cultured bovine chondrocytes, resulting in decreased cell viability and proteoglycan synthesis.
Akagi, M., Nishimura, S., Yoshida, K., Kakinuma, T., Sawamura, T., Munakata, H. and Hamanishi, C.
J Orthop Res, 24, 1782-1790, 2006

Dominant-negative LOX-1 blocks homodimerization of wild-type LOX-1-induced cell proliferation through extracellular signal regulated kinase 1/2 activation.
Tanigawa, H., Miura, S., Matsuo, Y., Fujino, M., Sawamura, T. and Saku, K.
Hypertension, 48, 294-300, 2006

Oxidized low density lipoprotein impairs endothelial progenitor cells by regulation of endothelial nitric oxide synthase.
Ma, F.X., Zhou, B., Chen, Z., Ren, Q., Lu, S.H., Sawamura, T. and Han, Z.C.
J Lipid Res, 47, 1227-1237, 2006

LOX-1 scavenger receptor mediates calcium-dependent recognition of phosphatidylserine and apoptotic cells.
Murphy, J.E., Tacon, D., Tedbury, P.R., Hadden, J.M., Knowling, S., Sawamura, T., Peckham, M., Phillips, S.E., Walker, J.H. and Ponnambalam, S.
Biochem J, 393, 107-115, 2006

Oxidized LDL receptor LOX-1 is involved in neointimal hyperplasia after balloon arterial injury in a rat model.
Hinagata, J., Kakutani, M., Fujii, T., Naruko, T., Inoue, N., Fujita, Y., Mehta, J.L., Ueda, M. and Sawamura, T.
Cardiovasc Res, 69, 263-271, 2006

LOX-1 unlocked.
Sawamura, T.
Structure (Camb), 13, 834-835, 2005

Different effect of statins on platelet oxidized-LDL receptor (CD36 and LOX-1) expression in hypercholesterolemic subjects.
Bruni, F., Pasqui, A.L., Pastorelli, M., Bova, G., Cercignani, M., Palazzuoli, A., Sawamura, T., Gioffre, W.R., Auteri, A. and Puccetti, L.
Clin Appl Thromb Hemost, 11, 417-428, 2005

Enhanced plasma levels of oxidized low-density lipoprotein increase circulating nuclear factor-kappa B activation in patients with unstable angina.
Cominacini, L., Anselmi, M., Garbin, U., Fratta Pasini, A., Stranieri, C., Fusaro, M., Nava, C., Agostoni, P., Keta, D., Zardini, P., Sawamura, T. and Lo Cascio, V.
J Am Coll Cardiol, 46, 799-806, 2005

Adhesion molecule expression in fibroblasts: alteration in fibroblast biology after transfection with LOX-1 plasmids.
Chen, K., Chen, J., Liu, Y., Xie, J., Li, D., Sawamura, T., Hermonat, P.L. and Mehta, J.L.
Hypertension, 46, 622-627, 2005

Essential role of cytoplasmic sequences for cell-surface sorting of the lectin-like oxidized LDL receptor-1 (LOX-1).
Chen, M. and Sawamura, T.
J Mol Cell Cardiol, 39, 553-561, 2005

Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E-null mice.
Inoue, K., Arai, Y., Kurihara, H., Kita, T. and Sawamura, T.
Circ Res, 97, 176-184, 2005

Angiotensin II increases the expression of lectin-like oxidized low-density lipoprotein receptor-1 in human vascular smooth muscle cells via a lipoxygenase-dependent pathway.
Limor, R., Kaplan, M., Sawamura, T., Sharon, O., Keidar, S., Weisinger, G., Knoll, E., Naidich, M. and Stern, N.
Am J Hypertens, 18, 299-307, 2005

Extracellular HSP70 binding to surface receptors present on antigen presenting cells and endothelial/epithelial cells.
Theriault, J.R., Mambula, S.S., Sawamura, T., Stevenson, M.A. and Calderwood, S.K.
FEBS Lett, 579, 1951-1960, 2005

Nebivolol decreases oxidative stress in essential hypertensive patients and increases nitric oxide by reducing its oxidative inactivation.
Pasini, A.F., Garbin, U., Nava, M.C., Stranieri, C., Davoli, A., Sawamura, T., Lo Cascio, V. and Cominacini, L.
J Hypertens, 23, 589-596, 2005

Atorvastatin reduces platelet-oxidized-LDL receptor expression in hypercholesterolaemic patients.
Puccetti, L., Sawamura, T., Pasqui, A.L., Pastorelli, M., Auteri, A. and Bruni, F.
Eur J Clin Invest, 35, 47-51, 2005

LOX-1, a lectin-like oxidized LDL receptor identified form endothelial cells, in endothelial dysfunction.
Sawamura, T.
International Congress Series, 1262, 531-534, 2004

Dynamin-2 regulates oxidized low-density lipoprotein-induced apoptosis of vascular smooth muscle cell.
Kashiwakura, Y., Watanabe, M., Kusumi, N., Sumiyoshi, K., Nasu, Y., Yamada, H., Sawamura, T., Kumon, H., Takei, K. and Daida, H.
Circulation, 110, 3329-3334, 2004

Expression of LOX-1, an oxidized low-density lipoprotein receptor, in choroidal neovascularization.
Honjo, M., Sawamura, T., Hinagata, J., Nakamura, K., Sanada, N., Tanihara, H., Honda, Y. and Kiryu, J.
Arch Ophthalmol, 122, 2004

Induction of endothelin-1 production in endothelial cells via co-operative action between CD40 and lectin-like oxidized LDL receptor (LOX-1).
Sakurai, K., Cominacini, L., Garbin, U., Fratta Pasini, A., Sasaki, N., Takuwa, Y., Masaki, T. and Sawamura, T.
J Cardiovasc Pharmacol, 44, S173-180, 2004

Lectin-like oxidized low-density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low-density lipoprotein in rheumatoid arthritis cartilage.
Kakinuma, T., Yasuda, T., Nakagawa, T., Hiramitsu, T., Akiyoshi, M., Akagi, M., Sawamura, T. and Nakamura, T.
Arthritis Rheum, 50, 3495-3503, 2004

Expression of lectin-like oxidized low-density lipoprotein receptor-1 in allografted hearts.
Suga, M., Sawamura, T., Nakatani, T. and Kitamura, S
Transplant Proc, 36, 2440-2442, 2004

C-reactive protein enhances LOX-1 expression in human aortic endothelial cells: relevance of LOX-1 to C-reactive protein-induced endothelial dysfunction.
Li, L., Roumeliotis, N., Sawamura, T. and Renier, G.
Circ Res, 95, 877-883, 2004

Lipids from oxidized low-density lipoprotein modulate human trophoblast invasion: involvement of nuclear liver X receptors.
Pavan, L., Hermouet, A., Tsatsaris, V., Therond, P., Sawamura, T., Evain-Brion, D. and Fournier, T.
Endocrinology, 145, 4583-4591, 2004

Upregulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in endothelial cells by nitric oxide deficiency.
Smirnova, I.V., Sawamura, T. and Goligorsky, M.S.
Am J Physiol Renal Physiol, 287, F25-32, 2004

Oxidized low-density lipoprotein (ox-LDL) binding to lectin-like ox-LDL receptor-1 (LOX-1) in cultured bovine articular chondrocytes increases production of intracellular reactive oxygen species (ROS) resulting in the activation of NF-kappaB.
Nishimura, S., Akagi, M., Yoshida, K., Hayakawa, S., Sawamura, T., Munakata, H. and Hamanishi, C.
Osteoarthritis Cartilage, 12, 568-576, 2004

Oxidized low-density lipoprotein induces endothelial progenitor cell senescence, leading to cellular dysfunction.
Imanishi, T., Hano, T., Sawamura, T. and Nishio, I.
Clin Exp Pharmacol Physiol, 31, 407-413, 2004

Asymmetric dimethylarginine upregulates LOX-1 in activated macrophages: role in foam cell formation.
Smirnova, I.V., Kajstura, M., Sawamura, T. and Goligorsky, M.S.
287, H782-790, 2004

Glucose enhances human macrophage LOX-1 expression: role for LOX-1 in glucose-induced macrophage foam cell formation.
Li, L., Sawamura, T. and Renier, G.
Circ Res, 94, 892-901, 2004

Stress and vascular responses: endothelial dysfunction via lectin-like oxidized low-density lipoprotein receptor-1: close relationships with oxidative stress.
Sakurai, K. and Sawamura, T.
J Pharmacol Sci, 91, 182-186, 2003

Modulation of endothelial Ca(2+)-activated K(+) channels by oxidized LDL and its contribution to endothelial proliferation.
Kuhlmann, C.R., Schafer, M., Li, F., Sawamura, T., Tillmanns, H., Waldecker, B. and Wiecha, J.
Cardiovasc Res, 60, 626-634, 2003

The platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells.
Cominacini, L., Fratta Pasini, A., Garbin, U., Pastorino, A., Rigoni, A., Nava, C., Davoli, A., Lo Cascio, V. and Sawamura, T.
J Am Coll Cardiol, 41, 499-507, 2003

Endothelin-1 receptor blockade prevents renal injury in experimental hypercholesterolemia.
Chade, A.R., Best, P.J., Rodriguez-Porcel, M., Herrmann, J., Zhu, X., Sawamura, T., Napoli, C., Lerman, A. and Lerman, L.O.
Kidney Int, 64, 962-969, 2003

Oxidized LDL through LOX-1 modulates LDL-receptor expression in human coronary artery endothelial cells.
Hu, B., Li, D., Sawamura, T. and Mehta, J.L.
Biochem Biophys Res Commun, 307, 1008-1012, 2003

Glucose enhances endothelial LOX-1 expression: role for LOX-1 in glucose-induced human monocyte adhesion to endothelium.
Li, L., Sawamura, T. and Renier, G.
DIABETES, 52, 1843-1850, 2003

Mechanisms of renal structural alterations in combined hypercholesterolemia and renal artery stenosis.
Chade, A.R., Rodriguez-Porcel, M., Grande, J.P., Zhu, X., Sica, V., Napoli, C., Sawamura, T., Textor, S.C., Lerman, A. and Lerman, L.O.
Arterioscler Thromb Vasc Biol, 23, 1295-1301, 2003

Hypertension exacerbates the effect of hypercholesterolemia on the myocardial microvasculature.
Rodriguez-Porcel, M., Lerman, A., Herrmann, J., Schwartz, R.S., Sawamura, T., Condorelli, M., Napoli, C. and Lerman, L.O.
Cardiovasc Res, 58, 213-221, 2003

Hypercholesterolemia and hypertension have synergistic deleterious effects on coronary endothelial function.
Rodriguez-Porcel, M., Lerman, L.O., Herrmann, J., Sawamura, T., Napoli, C. and Lerman, A.
Arterioscler Thromb Vasc Biol, 23, 885-891, 2003

Lipid-lowering-independent effects of simvastatin on the kidney in experimental hypercholesterolaemia.
Wilson, S.H., Chade, A.R., Feldstein, A., Sawamura, T., Napoli, C., Lerman, A. and Lerman, L.O.
Nephrol Dial Transplant, 18, 703-709, 2003

LOX-1, an oxidized LDL endothelial receptor, induces CD40/CD40L signaling in human coronary artery endothelial cells.
Li, D., Liu, L., Chen, H., Sawamura, T. and Mehta, J.L.
Arterioscler Thromb Vasc Biol, 23, 816-821, 2003

Expression of lectin-like oxidized low-density lipoprotein receptors during ischemia-reperfusion and its role in determination of apoptosis and left ventricular dysfunction.
Li, D., Williams, V., Liu, L., Chen, H., Sawamura, T., Romeo, F. and Mehta, J.L.
J Am Coll Cardiol, 41, 1048-1055, 2003

Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction.
Tatsuguchi, M., Furutani, M., Hinagata, J., Tanaka, T., Furutani, Y., Imamura, S., Kawana, M., Masaki, T., Kasanuki, H., Sawamura, T. and Matsuoka, R.
Biochem Biophys Res Commun, 2003

Nebivolol and its 4-keto derivative increase nitric oxide in endothelial cells by reducing its oxidative inactivation.
Cominacini, L., Fratta Pasini, A., Garbin, U., Nava, C., Davoli, A., Criscuoli, M., Crea, A., Sawamura, T. and Lo Cascio, V.
J Am Coll Cardiol, 42, 1838-1844, 2003

LOX-1 mediates oxidized low-density lipoprotein-induced expression of matrix metalloproteinases in human coronary artery endothelial cells.
Li, D., Liu, L., Chen, H., Sawamura, T., Ranganathan, S. and Mehta, J.L.
Circulation, 107, 612-617, 2003

Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation.
Honjo, M., Nakamura, K., Yamashiro, K., Kiryu, J., Tanihara, H., McEvoy, L.M., Honda, Y., Butcher, E.C., Masaki, T. and Sawamura, T.
Proc Natl Acad Sci U S A, 100, 1274-1279, 2003

LOX-1 pathway affects the extent of myocardial ischemia-reperfusion injury.
Kataoka, K., Hasegawa, K., Sawamura, T., Fujita, M., Yanazume, T., Iwai-Kanai, E., Kawamura, T., Hirai, T., Kita, T. and Nohara, R.
Biochem Biophys Res Commun, 300, 656-660, 2003

LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis.
Chen, M., Masaki, T. and Sawamura, T.
Pharmacol Ther, 95, 89, 2002

LOX-1 expressed in cultured rat chondrocytes mediates oxidized LDL-induced cell death-possible role of dephosphorylation of Akt.
Nakagawa, T., Yasuda, T., Hoshikawa, H., Shimizu, M., Kakinuma, T., Chen, M., Masaki, T., Nakamura, T. and Sawamura, T.
Biochem Biophys Res Commun, 299, 91-97, 2002

Oxidized low density lipoprotein potentiation of Fas-induced apoptosis through lectin-like oxidized-low density lipoprotein receptor-1 in human umbilical vascular endothelial cells.
Imanishi, T., Hano, T., Sawamura, T., Takarada, S. and Nishio, I.
Circ J, 66, 1060-1064, 2002

LOX-1 inhibition in myocardial ischemia-reperfusion injury: modulation of MMP-1 and inflammation.
Li, D., Williams, V., Liu, L., Chen, H., Sawamura, T., Antakli, T. and Mehta, J.L
Am J Physiol Heart Circ Physiol,, 283, H1795-1801, 2002

Lectin-like oxidized low-density lipoprotein receptor 1 mediates leukocyte infiltration and articular cartilage destruction in rat zymosan-induced arthritis.
Nakagawa, T., Akagi, M., Hoshikawa, H., Chen, M., Yasuda, T., Mukai, S., Ohsawa, K., Masaki, T., Nakamura, T. and Sawamura, T.
Arthritis Rheum, 46, 2486-2494, 2002

Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation.
Delneste, Y., Magistrelli, G., Gauchat, J., Haeuw, J., Aubry, J., Nakamura, K., Kawakami-Honda, N., Goetsch, L., Sawamura, T., Bonnefoy, J. and Jeannin, P.
Immunity, 17, 353-362, 2002

Augmented endothelial uptake of oxidized low-density lipoprotein in response to endothelin-1
Morawietz, H., Duerrschmidt, N., Niemann, B., Galle, J., Sawamura, T. and Holtz, J.
Clin Sci (Lond), 48, 9S-12S, 2002

A myosin light chain kinase inhibitor, ML-9, lowers the intraocular pressure in rabbit eyes.
Honjo, M., Inatani, M., Kido, N., Sawamura, T., Yue, B.Y., Honda, Y. and Tanihara, H.
Exp Eye Res, 75, 135-142, 2002

Statins modulate oxidized low-density lipoprotein-mediated adhesion molecule expression in human coronary artery endothelial cells: role of LOX-1.
Li, D., Chen, H., Romeo, F., Sawamura, T., Saldeen, T. and Mehta, J.L.
J Pharmacol Exp Ther, 302, 601-605, 2002

Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products (AGE).
Jono, T., Miyazaki, A., Nagai, R., Sawamura, T., Kitamura, T. and Horiuchi, S.
FEBS Lett, 511, 170-174, 2002

Statin inhibits leukocyte-endothelial interaction and prevents neuronal death induced by ischemia-reperfusion injury in the rat retina.
Honjo, M., Tanihara, H., Nishijima, K., Kiryu, J., Honda, Y., Yue, B.Y. and Sawamura, T
Arch Ophthalmol, 120, 1707-1713, 2002

Activation of lectin-like oxidized low-density lipoprotein receptor-1 induces apoptosis in cultured neonatal rat cardiac myocytes.
Iwai-Kanai, E., Hasegawa, K., Sawamura, T., Fujita, M., Yanazume, T., Toyokuni, S., Adachi, S., Kihara, Y. and Sasayama, S.
Circulation, 104, 2948-2954, 2001

Diabetes enhances lectin-like oxidized LDL receptor-1 (LOX-1) expression in the vascular endothelium: possible role of LOX-1 ligand and AGE.
Chen, M., Nagase, M., Fujita, T., Narumiya, S., Masaki, T. and Sawamura, T.
Biochem Biophys Res Commun, 287, 962-968, 2001

Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes.
Honjo, M., Inatani, M., Kido, N., Sawamura, T., Yue, B.Y., Honda, Y. and Tanihara, H.
Arch Ophthalmol, 119, 1171-1178, 2001

Requirements of basic amino acid residues within the lectin-like domain of LOX-1 for the binding of oxidized low-density lipoprotein.
Chen, M., Inoue, K., Narumiya, S., Masaki, T. and Sawamura, T.
FEBS Lett, 499, 215-219, 2001

Induction of the oxLDL receptor LOX-1 by endothelin-1 in human endothelial cells.
Morawietz, H., Duerrschmidt, N., Niemann, B., Galle, J., Sawamura, T. and Holtz, J.
Biochem Biophys Res Commun, 284, 961-965, 2001

8-iso-prostaglandin F(2alpha) increases expression of LOX-1 in JAR cells.
Halvorsen, B., Staff, A.C., Henriksen, T., Sawamura, T. and Ranheim, T.
Hypertension, 37, 1184-1190, 2001

LOX-1 supports adhesion of gram-positive and gram-negative bacteria.
Shimaoka, T., Kume, N., Minami, M., Hayashida, K., Sawamura, T., Kita, T. and Yonehara, S.
J Immunol, 166, 5108-5114, 2001

Conserved C-terminal residues within the lectin-like domain of LOX-1 are essential for oxidized low-density-lipoprotein binding.
Chen, M., Narumiya, S., Masaki, T. and Sawamura, T.
Biochem J, 355, 289-296, 2001

The binding of oxidized low density lipoprotein (ox-LDL) to ox-LDL receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells through an increased production of superoxide.
Cominacini, L., Rigoni, A., Pasini, A.F., Garbin, U., Davoli, A., Campagnola, M., Pastorino, A.M., Lo Cascio, V. and Sawamura, T.
J Biol Chem, 276, 13750-13755, 2001

Accumulation of LOX-1 ligand in plasma and atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits: identification by a novel enzyme immunoassay.
Kakutani, M., Ueda, M., Naruko, T., Masaki, T. and Sawamura, T.
Biochem Biophys Res Commun, 282, 180-185, 2001

Activation-dependent surface expression of LOX-1 in human platelets.
Chen, M., Kakutani, M., Naruko, T., Ueda, M., Narumiya, S., Masaki, T. and Sawamura, T.
Biochem Biophys Res Commun,, 282, 153-158, 2001

Redox-sensitive regulation of lox-1 gene expression in vascular endothelium.
Nagase, M., Ando, K., Nagase, T., Kaname, S., Sawamura, T. and Fujita, T.
Biochem Biophys Res Commun, 281, 720-725, 2001

Identification of peptides that target the endothelial cell-specific LOX-1 receptor.
White, S.J., Nicklin, S.A., Sawamura, T. and Baker, A.H.
Hypertension, 37, 449-455, 2001

Pericardial fluid from patients with ischemic heart disease induces myocardial cell apoptotis via an oxidant stress-sensitive p38 mitogen-activated protein kinase pathway.
Iwakura, A., Fujita, M., Hasegawa, K., Toyokuni, S., Sawamura, T., Nohara, R., Sasayama, S. and Komeda, M.
J Mol Cell Cardiol, 33, 419-430, 2001

Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility.
Honjo, M., Tanihara, H., Inatani, M., Kido, N., Sawamura, T., Yue, B.Y., Narumiya, S. and Honda, Y.
Invest Ophthalmol Vis Sci, 42, 137-144, 2001

Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) supports cell adhesion to fibronectin.
Shimaoka, T., Kume, N., Minami, M., Hayashida, K., Sawamura, T., Kita, T. and Yonehara, S.
FEBS Lett, 504, 65-68, 2001

Regeneration of cardiac muscle in normal adult C57BL/6 mice.
Jiang, H., Hidaka, K., Sawamura, T., Arai, Y., Takihara, Y., Ota, A. and Morisaki, T.
Cardiac and Vascular Regeneration, 1, 268-273, 2000

Endothelin-1 as a protective factor against beta-adrenergic agonist-induced apoptosis in cardiac myocytes.
Araki, M., Hasegawa, K., Iwai-Kanai, E., Fujita, M., Sawamura, T., Kakita, T., Wada, H., Morimoto, T. and Sasayama, S.
J Am Coll Cardiol, 36, 1411-1418, 2000

Upregulation of LOX-1 expression in aorta of hypercholesterolemic rabbits: modulation by losartan.
Chen, H., Li, D., Sawamura, T., Inoue, K. and Mehta, J.L.
Biochem Biophys Res Commun, 276, 1100-1104, 2000

Expression of LOX-1, an oxidized low-density lipoprotein receptor, in experimental hypertensive glomerulosclerosis.
Nagase, M., Kaname, S., Nagase, T., Wang, G., Ando, K., Sawamura, T. and Fujita, T.
J Am Soc Nephrol, 11, 1826-1836,, 2000

Pericardial fluid from patients with ischemic heart disease accelerates the growth of human vascular smooth muscle cells.
Yoneda, T., Fujita, M., Kihara, Y., Hasegawa, K., Sawamura, T., Tanaka, T., Inanami, M., Nohara, R. and Sasayama, S.
Jpn Circ J, 64, 495-498, 2000

Expression of lectin-like oxidized LDL receptor-1 in human atherosclerotic lesions.
Kataoka, H., Kume, N., Minami, M., Moriwaki, H., Sawamura, T., Masaki, T. and Kita, T.
Ann N Y Acad Sci, 902, 328-335, 2000

Inducible expression of LOX-1, a novel receptor for oxidized LDL, in macrophages and vascular smooth muscle cells.
Kume, N., Moriwaki, H., Kataoka, H., Minami, M., Murase, T., Sawamura, T., Masaki, T. and Kita, T.
Ann N Y Acad Sci, 902, 323-327, 2000

Pericardial fluid from patients with unstable angina induces vascular endothelial cell apoptosis.
Iwakura, A., Fujita, M., Hasegawa, K., Sawamura, T., Nohara, R., Sasayama, S. and Komeda, M.
J Am Coll Cardiol, 35, 1785-1790, 2000

Transforming growth factor-beta(1) increases the expression of lectin-like oxidized low-density lipoprotein receptor-1.
Minami, M., Kume, N., Kataoka, H., Morimoto, M., Hayashida, K., Sawamura, T., Masaki, T. and Kita, T.
Biochem Biophys Res Commun,, 272, 357-361, 2000

Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species.
Cominacini, L., Pasini, A.F., Garbin, U., Davoli, A., Tosetti, M.L., Campagnola, M., Rigoni, A., Pastorino, A.M., Lo Cascio, V. and Sawamura, T.
J Biol Chem, 275, 12633-12638, 2000

Increased expression of lectin-like oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits.
Chen, M., Kakutani, M., Minami, M., Kataoka, H., Kume, N., Narumiya, S., Kita, T., Masaki, T. and Sawamura, T.
Arterioscler Thromb Vasc Biol, 20, 1107-1115,, 2000

Identification of soluble forms of lectin-like oxidized LDL receptor-1.
Murase, T., Kume, N., Kataoka, H., Minami, M., Sawamura, T., Masaki, T. and Kita, T.
Arterioscler Thromb Vasc Biol, 20, 2000

Biosynthesis and post-translational processing of lectin-like oxidized low density lipoprotein receptor-1 (LOX-1). N-linked glycosylation affects cell-surface expression and ligand binding.
Kataoka, H., Kume, N., Miyamoto, S., Minami, M., Murase, T., Sawamura, T., Masaki, T., Hashimoto, N. and Kita, T.
J Biol Chem, 275, 6573-6579, 2000

LOX-1 mediates lysophosphatidylcholine-induced oxidized LDL uptake in smooth muscle cells.
Aoyama, T., Chen, M., Fujiwara, H., Masaki, T. and Sawamura, T.
FEBS Lett, 467, 217-220, 2000

A platelet-endothelium interaction mediated by lectin-like oxidized low-density lipoprotein receptor-1.
Kakutani, M., Masaki, T. and Sawamura, T.
Proc Natl Acad Sci U S A, 97, 360-364, 2000

Subcellular mechanisms of endothelin action in vascular system.
Masaki, T., Miwa, S., Sawamura, T., Ninomiya, H and Okamoto, Y.
Eur J Pharmacol, 375, 133-138, 1999

Northern blot analysis to quantify gene expression in vascular diseases.
Chen M. and Sawamura, T.
Methods in Molecular Biology, 30, 181-188, 1999

Subcellular mechanisms of endothelin action in vascular system.
Masaki, T., Miwa, S., Sawamura, T., Ninomiya, H. and Okamoto, Y.
Eur J Pharmacol, 375, 133-138, 1999

Induction of lectin-like oxidized LDL receptor by oxidized LDL and lysophosphatidylcholine in cultured endothelial cells.
Aoyama, T., Fujiwara, H., Masaki, T. and Sawamura, T.
J Mol Cell Cardiol, 31, 2101-2114, 1999

Angiotensin II induces LOX-1, the human endothelial receptor for oxidized low-density lipoprotein.
Morawietz, H., Rueckschloss, U., Niemann, B., Duerrschmidt, N., Galle, J., Hakim, K., Zerkowski, H.R., Sawamura, T. and Holtz, J.
Circulation, 100, 899-902, 1999

Neuron-specific expression of cationic amino acid transporter 3 in the adult rat brain.
Hosokawa, H., Ninomiya, H., Sawamura, T., Sugimoto, Y., Ichikawa, A., Fujiwara, K. and Masaki, T.
Brain Res, 838, 158-165, 1999

Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions.
Kataoka, H., Kume, N., Miyamoto, S., Minami, M., Moriwaki, H., Murase, T., Sawamura, T., Masaki, T., Hashimoto, N. and Kita, T.
Circulation, 99, 3110-3117, 1999

Upregulation of endothelial receptor for oxidized low-density lipoprotein (LOX-1) in cultured human coronary artery endothelial cells by angiotensin II type 1 receptor activation.
Li, D.Y., Zhang, Y.C., Philips, M.I., Sawamura, T. and Mehta, J.L.
Circ Res, 84, 1043-1049, 1999

Structure and chromosomal assignment of the human lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1) gene.
Aoyama, T., Sawamura, T., Furutani, Y., Matsuoka, R., Yoshida, M.C., Fujiwara, H. and Masaki, T.
Biochem J, 339, 177-184, 1999

The role of endothelin-converting enzyme-1 in the development of alpha1-adrenergic-stimulated hypertrophy in cultured neonatal rat cardiac myocytes.
Kaburagi, S., Hasegawa, K., Morimoto, T., Araki, M., Sawamura, T., Masaki, T. and Sasayama, S.
Circulation, 99, 292-298, 1999

Fluid shear stress transcriptionally induces lectin-like oxidized LDL receptor-1 in vascular endothelial cells.
Murase, T., Kume, N., Korenaga, R., Ando, J., Sawamura, T., Masaki, T. and Kita, T.
Circ Res, 83, 328-333, 1998

Increased Cat3-mediated cationic amino acid transport functionally compensates in Cat1 knockout cell lines.
Nicholson, B., Sawamura, T., Masaki, T. and MacLeod, C.L.
J Biol Chem, 273, 14663-14666, 1998

Expression of lectin-like oxidized low density lipoprotein receptor-1 in human and murine macrophages: upregulated expression by TNF-alpha.
1Moriwaki, H., Kume, N., Kataoka, H., Murase, T., Nishi, E., Sawamura, T., Masaki, T. and Kita, T.
FEBS Lett, 440, 29-32, 1998

High-affinity arginine transport of bovine aortic endothelial cells is impaired by lysophosphatidylcholine.
Kikuta, K., Sawamura, T., Miwa, S., Hashimoto, N. and Masaki, T.
Circ Res, 83, 1088-1096, 1998

Ligand specificity of LOX-1, a novel endothelial receptor for oxidized low density lipoprotein.
Moriwaki, H., Kume, N., Sawamura, T., Aoyama, T., Hoshikawa, H., Ochi, H., Nishi, E., Masaki, T. and Kita, T.
Arterioscler Thromb Vasc Biol, 18, 1541-1547, 1998

Role of nonselective cation channels as Ca2+ entry pathway in endothelin-1-induced contraction and their suppression by nitric oxide.
Zhang, X.F., Komuro, T., Miwa, S., Minowa, T., Iwamuro, Y., Okamoto, Y., Ninomiya, H., Sawamura, T. and Masaki, T.
Eur J Pharmacol, 352, 237-245, 1998

Inducible expression of lectin-like oxidized LDL receptor-1 in vascular endothelial cells.
Kume, N., Murase, T., Moriwaki, H., Aoyama, T., Sawamura, T., Masaki, T. and Kita, T.
Circ Res, 83, 322-327, 1998

Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells.
Oka, K., Sawamura, T., Kikuta, K., Itokawa, S., Kume, N., Kita, T. and Masaki, T.
Proc Natl Acad Sci U S A, 95, 9535-9540, 1998

Purification of a novel endothelin-converting enzyme specific for big endothelin-3.
Hasegawa, H., Hiki, K., Sawamura, T., Aoyama, T., Okamoto, Y., Miwa, S., Shimohama, S., Kimura, J. and Masaki, T.
FEBS Lett, 428, 304-308, 1998

The processing pathway of endothelin-1 production.
Kido, T., Sawamura, T. and Masaki, T.
J Cardiovasc Pharmacol, 31, S13-15, 1998

High affinity binding of oxidized LDL to mouse lectin-like oxidized LDL receptor (LOX-1).
Hoshikawa, H., Sawamura, T., Kakutani, M., Aoyama, T., Nakamura, T. and Masaki, T.
Biochem Biophys Res Commun, 245, 841-846, 1998

Marked elevation of vascular endothelial growth factor and basic fibroblast growth factor in pericardial fluid of patients with angina pectoris.
Fujita, M., Ikemoto, M., Tanaka, T., Tamaki, S., Yamazato, A., Sawamura, T., Hasegawa, K., Kihara, Y., Nohara, R. and Sasayama, S.
Angiogenesis, 2, 105-108, 1998

Physiological role of Ca2+-permeable nonselective cation channel in endothelin-1-induced contraction of rabbit aorta.
Komuro, T., Miwa, S., Zhang, X.F., Minowa, T., Enoki, T., Kobayashi, S., Okamoto, Y., Ninomiya, H., Sawamura, T., Kikuta, K., Iwamuro, Y., Furutani, H., Hasegawa, H., Uemura, Y., Kikuchi, H. and Masaki, T.
J Cardiovasc Pharmacol, 30, 504-509, 1997

Enhanced expression of endothelial oxidized low-density lipoprotein receptor (LOX-1) in hypertensive rats.
Nagase, M., Hirose, S., Sawamura, T., Masaki, T. and Fujita, T.
Biochem Biophys Res Commun, 237, 496-498, 1997

Processing of proendothelin-1 at the C-terminus of big endothelin-1 is essential for proteolysis by endothelin-converting enzyme-1 in vivo.
Kido, T., Sawamura, T., Hoshikawa, H., D'Orleans-Juste, P., Denault, J.B., Leduc, R., Kimura, J. and Masaki, T.
Eur J Biochem, 244, 520-526, 1997

An endothelial receptor for oxidized low-density lipoprotein.
Sawamura, T., Kume, N., Aoyama, T., Moriwaki, H., Hoshikawa, H., Aiba, Y., Tanaka, T., Miwa, S., Katsura, Y., Kita, T. and Masaki, T.
Nature, 386, 73-77, 1997

Cloning and characterization of a brain-specific cationic amino acid transporter.
Hosokawa, H., Sawamura, T., Kobayashi, S., Ninomiya, H., Miwa, S. and Masaki, T.
J Biol Chem, 272, 8717-8722, 1997

Human endothelin converting enzyme gene (ECE1) mapped to chromosomal region 1p36.1.
Matsuoka, R., Sawamura, T., Yamada, K., Yoshida, M., Furutani, Y., Ikura, T., Shiraki, T., Hoshikawa, H., Shimada, K., Tanzawa, K. and Masaki, T.
Cytogenet Cell Genet, 72, 322-324, 1996

Processing of proendothelin-1 by human furin convertase.
Denault, J.B., Claing, A., D'Orleans-Juste, P., Sawamura, T., Kido, T., Masaki, T. and Leduc, R.
FEBS Lett, 362, 276-280, 1995

cDNA cloning and expression of bovine endothelin converting enzyme.
Ikura, T., Sawamura, T., Shiraki, T., Hosokawa, H., Kido, T., Hoshikawa, H., Shimada, K., Tanzawa, K., Kobayashi, S., Miwa, S. and Masaki, T.
Biochem Biophys Res Commun, 203, 1417-1422, 1994

Genetic transfer of endothelin converting enzyme activity to CHO-K1 cells: detection of positive cells by reverse hemolytic plaque assay.
Shiraki, T., Sawamura, T., Ikura, T., Kobayashi, S., Miwa, S. and Masaki, T.
FEBS Lett, 351, 197-200, 1994

Distinct subdomains of human endothelin receptors determine their selectivity to endothelinA-selective antagonist and endothelinB-selective agonists.
Sakamoto, A., Yanagisawa, M., Sawamura, T., Enoki, T., Ohtani, T., Sakurai, T., Nakao, K., Toyo-oka, T. and Masaki,
J Biol Chem, 268, 8547-8553, 1993

Characterization of phosphoramidon-sensitive metalloproteinases with endothelin-converting enzyme activity in porcine lung membrane.
Sawamura, T., Shinmi, O., Kishi, N., Sugita, Y., Yanagisawa, M., Goto, K., Masaki, T. and Kimura, S.
Biochim Biophys Acta, 1161, 295-302, 1993

Phosphoramidon inhibits the intracellular conversion of big endothelin-1 to endothelin-1 in cultured endothelial cells.
Sawamura, T., Kasuya, Y., Matsushita, Y., Suzuki, N., Shinmi, O., Kishi, N., Sugita, Y., Yanagisawa, M., Goto, K., Masaki, T. and Kimura, S.
Biochem Biophys Res Commun, 174, 779-784, 1991

Distribution of endothelin-like immunoreactivity and mRNA in the developing and adult human lung.
Giaid, A., Polak, J.M., Gaitonde, V., Hamid, Q.A., Moscoso, G., Legon, S., Uwanogho, D., Roncalli, M., Shinmi, O., Sawamura, T., Kimura, S., Yanagisawa, M., Masaki, T. and Springal, D.R.
Am J Respir Cell Mol Biol, 4, 50-58, 1991

Analysis of big endothelin-1 digestion by cathepsin D.
Sawamura, T., Shinmi, O., Kishi, N., Sugita, Y., Yanagisawa, M., Goto, K., Masaki, T. and Kimura, S.
Biochem Biophys Res Commun, 172, 883-889, 1990

Detection of endothelin immunoreactivity and mRNA in pulmonary tumours.
Giaid, A., Hamid, Q.A., Springall, D.R., Yanagisawa, M., Shinmi, O., Sawamura, T., Masaki, T., Kimura, S., Corrin, B. and Polak, J.M.
J Pathol, 162, 15-22, 1990

Increased maternal plasma concentration of endothelin-1 during labor pain or on delivery and the existence of a large amount of endothelin-1 in amniotic fluid.
Usuki, S., Saitoh, T., Sawamura, T., Suzuki, N., Shigemitsu, S., Yanagisawa, M., Goto, K., Onda, H., Fujino, M. and Masaki, T.
Gynecol Endocrinol, 4, 85-97, 1990

Characterization of endothelin converting enzyme activities in soluble fraction of bovine cultured endothelial cells.
Sawamura, T., Kimura, S., Shinmi, O., Sugita, Y., Kobayashi, M., Mitsui, Y., Yanagisawa, M., Goto, K. and Masaki, T.
Biochem Biophys Res Commun, 169, 1138-1144, 1990

Purification and characterization of putative endothelin converting enzyme in bovine adrenal medulla: evidence for a cathepsin D-like enzyme.
Sawamura, T., Kimura, S., Shinmi, O., Sugita, Y., Yanagisawa, M., Goto, K. and Masaki, T.
Biochem Biophys Res Commun, 168, 1230-1236, 1990

Presence of endothelin-1 in porcine spinal cord: isolation and sequence determination.
Shinmi, O., Kimura, S., Yoshizawa, T., Sawamura, T., Uchiyama, Y., Sugita, Y., Kanazawa, I., Yanagisawa, M., Goto, K. and Masaki, T.
Biochem Biophys Res Commun, 162, 340-346, 1989

Endothelin-3 is a novel neuropeptide: isolation and sequence determination of endothelin-1 and endothelin-3 in porcine brain.
Shinmi, O., Kimura, S., Sawamura, T., Sugita, Y., Yoshizawa, T., Uchiyama, Y., Yanagisawa, M., Goto, K., Masaki, T. and Kanazawa, I.
Biochem Biophys Res Commun, 164, 587-593, 1989

Analysis of endothelin related peptides in culture supernatant of porcine aortic endothelial cells: evidence for biosynthetic pathway of endothelin-1.
Sawamura, T., Kimura, S., Shinmi, O., Sugita, Y., Yanagisawa, M. and Masaki, T.
Biochem Biophys Res Commun, 162, 1287-1294, 1989

Conversion of big endothelin-1 to 21-residue endothelin-1 is essential for expression of full vasoconstrictor activity: structure-activity relationships of big endothelin-1.
Kimura, S., Kasuya, Y., Sawamura, T., Shinimi, O., Sugita, Y., Yanagisawa, M., Goto, K. and Masaki, T.
J Cardiovasc Pharmacol, 13, S5-7, 1989

Structure-activity relationships of endothelin: importance of the C-terminal moiety.
Kimura, S., Kasuya, Y., Sawamura, T., Shinmi, O., Sugita, Y., Yanagisawa, M., Goto, K. and Masaki, T.
Biochem Biophys Res Commun, 156, 1182-1186, 1988