Cardiology

General internal medicine

Metabolism and endocrinology

Genome biology

Molecular biology

Cardiology, Cardiovascular Medicine, Molecular Cardiology,Cardiovascular Endocrinology and Metabolism

2023 - Present
信州大学医学部附属病院, 脳卒中・心臓病等総合支援センター, センター長

2023 - Present
信州大学医学部附属病院先端心臓血管病センター, センター長

2016 - Present
信州大学医学部附属病院胸痛センター, センター長

2016 - Present
信州大学医学部, 循環器内科学教室（内科学第五教室）, 教授

2009 - 2016
Kyoto University, 講師

2009 - 2009
京都大学大学院医学研究科, 特定講師

2005 - 2009
京都大学大学院医学研究科, 産学連携講師

2003 - 2005
テキサス大学サウスウエスタン医学研究所, 分子生物学講座, フェロー

2003 - 2003
京都大学大学院医学研究科, 臨床病態医科学, 医員

2000 - 2003
京都大学大学院医学研究科, 臨床病態医科学, 日本学術振興会特別研究員

1999 - 2000
京都大学大学院医学研究科, 臨床病態医科学, 医員

1992 - 1995
静岡市立静岡病院, 内科, 研修医

1991 - 1992
京都大学医学部附属病院, 内科, 研修医

1999 - 1999, 京都大学大学院医学研究科, 臨床病態医科学

1995 - 1999, Kyoto University, 大学院医学研究科博士課程（内科系専攻）

1985 - 1991, Kyoto University, 医学部

2023 - Present
理事, 日本腫瘍循環器学会

2023 - Present
第89回・第90回日本循環器学会学術集会プログラム検討カテゴリー(心不全・心筋症・移植）メンバー, 日本循環器学会

2022 - Present
学術委員, 日本高血圧学会

2022 - Present
評議員, 日本高血圧学会

2022 - Present
国際交流委員会 委員, 日本心臓病学会

2022 - Present
総務/将来構想委員会 副委員長, 日本心臓病学会

2022 - Present
研究推進・若手医師育成員会副委員長, 日本心臓病学会

2022 - Present
理事, 日本心臓病学会

2022 - Present
埋込型VAD事後検証部会委員, 日本循環器学会

2022 - Present
心臓移植適応検討部会委員, 日本循環器学会

2022 - Present
渉外委員会委員（国際）, 日本循環器学会

2022 - Present
ガイドライン部会委員, 日本循環器学会

2021 - Present
理事, 日本循環器協会

2021 - 2022
生涯教育委員, 日本内科学会

2020 - Present
評議員, 日本肺高血圧・肺循環器学会

2020 - Present
出版・編集委員会委員長, 日本心不全学会

2020 - Present
社員, 日本循環器学会

2020 - Present
BCVR基礎研究部会委員, 日本循環器学会

2020 - 2022
研究推進・若手医師育成員会委員, 日本心臓病学会

2020 - 2020
あり方委員会委員, 日本内科学会

2019 - Present
心アミロイドーシス調査研究WG委員, 日本循環器学会

2018 - Present
評議員, 日本腫瘍循環器学会

2018 - Present
評議員, 日本心臓リハビリテーション学会

2018 - Present
国内交流委員会委員, 日本心不全学会

2018 - Present
顕彰委員会委員, 日本心不全学会

2018 - Present
理事, 日本心不全学会

2018 - 2020
学術委員会委員, 日本心臓病学会

2018
理事, 国際心臓研究学会(ISHR)日本部会

2018
学術委員会委員, 日本心不全学会

2018
評議員, 日本内科学会

2017 - Present
理事, 日本心血管内分泌代謝学会

2017 - 2019
専門医制度審議会委員, 日本内科学会

2010 - Present
評議員, 日本臨床分子医学会

2007 - Present
評議員, 日本内分泌学会

2015
日本心不全学会, 学術賞
International academic award

2015
日本臨床分子医学会, 学会賞
International academic award

2013
日本心臓財団, 佐藤賞
International academic award

2010
日本内分泌学会, 研究奨励賞
International academic award

2009
日本心血管内分泌代謝学会, 第13回高峰譲吉研究奨励賞
International academic award

2005
American Heart Association, New Investigator Travel Award
International academic award

2004
日本循環器学会, 第14回八木賞
International academic award

2002
Cardiovascular System Dynamics Society, Kiichi Sagawa Young Investigator Award Finalist
International academic award

2001
日本心血管内分泌代謝学会, 若手研究者奨励賞
International academic award

2001
American Heart Association, Melvin L. Marcus Young Investigator Award Finalist
International academic award

2001
日本内分泌学会, 若手研究者奨励賞
International academic award

2001
日本心脈管作動物質学会, 研究奨励賞
International academic award

2000
日本循環器学会, 若手研究者奨励賞
International academic award

1999
日本心不全学会, 若手研究者奨励賞
International academic award

1999
日本臨床分子医学会, Academic Encouragement Award
International academic award
Koichiro Kuwahara

A novel predictive score model for successful weaning from mechanical circulatory support in patients with cardiogenic shock.
Sho Suzuki; Nami Teraoka; Kii Ito; Yukari Okuma; Kazuhiro Kimura; Masatoshi Minamisawa; Soichiro Ebisawa; Hirohiko Motoki; Hiroshi Imamura; Tatsuichiro Seto; Koichiro Kuwahara
Journal of cardiac failure, Aug. 2024
Lead

Factors influencing the efficacy and safety of esaxerenone in hypertensive patients: a pooled analysis of five clinical studies on different comorbidities.
Kazuomi Kario; Tomohiro Katsuya; Jun Wada; Hirohiko Motoki; Koichiro Kuwahara; Kenichi Tsujita; Takashi Taguchi; Ayumi Tanabe; Tatsuo Shimosawa
Hypertension research : official journal of the Japanese Society of Hypertension, Aug. 2024
Lead

Treatment time limit for successful weaning from veno-arterial extracorporeal membrane oxygenation in cardiogenic shock.
Sho Suzuki; Kii Ito; Nami Teraoka; Yukari Okuma; Kazuhiro Kimura; Masatoshi Minamisawa; Soichiro Ebisawa; Hirohiko Motoki; Hiroshi Imamura; Tatsuichiro Seto; Koichiro Kuwahara
ESC heart failure, Jul. 2024
Lead

Impact of hyper-polypharmacy due to non-cardiovascular medications on long-term clinical outcomes following endovascular treatment for lower limb artery disease: A sub-analysis of the I-PAD Nagano registry.
Tamon Kato; Masatoshi Minamisawa; Takashi Miura; Masafumi Kanai; Yushi Oyama; Naoto Hashizume; Daisuke Yokota; Minami Taki; Keisuke Senda; Ken Nishikawa; Tadamasa Wakabayashi; Koki Fujimori; Kenichi Karube; Takahiro Sakai; Minami Inoue; Hidetsugu Yoda; Daisuke Sunohara; Yoshiteru Okina; Hidetomo Nomi; Yusuke Kanzaki; Keisuke Machida; Daisuke Kashiwagi; Yasushi Ueki; Tatsuya Saigusa; Soichiro Ebisawa; Ayako Okada; Hirohiko Motoki; Koichiro Kuwahara
Journal of cardiology, Jul. 2024
Lead

A tri-leaflet mitral valve with left ventricular non-compaction cardiomyopathy.
Junko Iguchi; Sho Suzuki; Kazuhiro Kimura; Masatoshi Minamisawa; Koichiro Kuwahara
European heart journal. Imaging methods and practice, 2(3), qyae111, Jul. 2024
Lead

Validation and Comparison of the Prognosis Predicting Ability of Inflammation-Based Scores Following Endovascular Treatment for Peripheral Artery Disease.
Tadashi Itagaki; Soichiro Ebisawa; Tamon Kato; Takashi Miura; Yushi Oyama; Naoto Hashizume; Daisuke Yokota; Minami Taki; Keisuke Senda; Yoshiteru Okina; Tadamasa Wakabayashi; Kouki Fujimori; Kenichi Karube; Takahiro Sakai; Fumika Nomoto; Toshifumi Takamatsu; Kiu Tanaka; Tomoaki Mochidome; Tatsuya Saigusa; Hirohiko Motoki; Toshio Kasai; Uichi Ikeda; Koichiro Kuwahara
Angiology, 75(6), 536-545, Jul. 2024
Lead

サクビトリルは腎虚血再灌流による拡張型心筋症モデルマウスの腎障害を改善する
石村 拓也; 石井 輝; 山田 博之; 中川 靖章; 杉岡 清香; 桑原 宏一郎; 柳田 素子; 横井 秀基
日本腎臓学会誌, 66(4), 626-626, Jun. 2024
Lead

Efficacy and safety of remote cardiac rehabilitation in the recovery phase of cardiovascular diseases (RecRCR study): A multicenter, nonrandomized, and interventional trial in Japan.
Hidetaka Itoh; Eisuke Amiya; Takahiro Jimba; Mai Shimbo; Koichi Narita; Masanobu Taya; Toshiaki Kadokami; Takanori Yasu; Hideki Oka; Masakazu Sogawa; Hiroyoshi Yokoi; Kazuo Mizutani; Shin-Ichiro Miura; Tatsuo Tokeshi; Ayumi Date; Takahisa Noma; Daisuke Kutsuzawa; Soichiro Usui; Shigeo Sugawara; Masanori Kanazawa; Hisakuni Sekino; Miho Nishitani Yokoyama; Takahiro Okumura; Yusuke Ugata; Shinichiro Fujishima; Kagami Hirabayashi; Yuta Ishizaki; Koichiro Kuwahara; Yuko Kaji; Hiroki Shimizu; Teruyuki Koyama; Hitoshi Adachi; Yoko Kurumatani; Ryoji Taniguchi; Katsuhiko Ohori; Hirokazu Shiraishi; Takashi Hasegawa; Shigeru Makita; Issei Komuro; Yutaka Kimura
International journal of cardiology. Heart & vasculature, 52, 101421-101421, Jun. 2024
Lead

Balcinrenone plus dapagliflozin in patients with heart failure and chronic kidney disease: Results from the phase 2b MIRACLE trial.
Carolyn S P Lam; Lars Køber; Koichiro Kuwahara; Lars H Lund; Patrick B Mark; Linda G Mellbin; Morten Schou; Patricia Ely Pizzato; Anders Gabrielsen; Samvel B Gasparyan; Alessandro Ghiretti; Judith Hartleib-Geschwindner; Greggory J Housler; Paolo Fanti; Maria Leonsson-Zachrisson; John J V McMurray; Scott D Solomon
European journal of heart failure, May 2024
Lead

Development of interpretable machine learning models to predict in-hospital prognosis of acute heart failure patients.
Munekazu Tanaka; Hirohiko Kohjitani; Erika Yamamoto; Takeshi Morimoto; Takao Kato; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Yuta Seko; Masayuki Shiba; Yusuke Yoshikawa; Yugo Yamashita; Takeshi Kitai; Ryoji Taniguchi; Moritake Iguchi; Kazuya Nagao; Takafumi Kawai; Akihiro Komasa; Yuichi Kawase; Takashi Morinaga; Mamoru Toyofuku; Yutaka Furukawa; Kenji Ando; Kazushige Kadota; Yukihito Sato; Koichiro Kuwahara; Yasushi Okuno; Takeshi Kimura; Koh Ono
ESC heart failure, May 2024
Lead

Regeneration of Nonhuman Primate Hearts With Human Induced Pluripotent Stem Cell-Derived Cardiac Spheroids.
Hideki Kobayashi; Shugo Tohyama; Hajime Ichimura; Noburo Ohashi; Shuji Chino; Yusuke Soma; Hidenori Tani; Yuki Tanaka; Xiao Yang; Naoko Shiba; Shin Kadota; Kotaro Haga; Taijun Moriwaki; Yuika Morita-Umei; Tomohiko C Umei; Otoya Sekine; Yoshikazu Kishino; Hideaki Kanazawa; Hiroyuki Kawagishi; Mitsuhiko Yamada; Kazumasa Narita; Takafumi Naito; Tatsuichiro Seto; Koichiro Kuwahara; Yuji Shiba; Keiichi Fukuda
Circulation, Apr. 2024, Refereed
Lead

Oral nutritional supplements in older outpatients with heart failure: rationale and design of the ALIMENT-HF trial.
Yudai Fujimoto; Taishi Dotare; Emi Maekawa; Kentaro Kamiya; Takeshi Kitai; Koichiro Kuwahara; Teruyasu Sugano; Masaaki Konishi; Tomohito Ohtani; Yoko Sakamoto; Kentaro Jujo; Chiharu Noda; Junya Ako; Naotake Yanagisawa; Yuya Matsue
ESC heart failure, Apr. 2024
Lead

Two different right ventricular pacing waveforms.
Toshinori Komatsu; Ayako Okada; Koichiro Kuwahara
European heart journal. Case reports, 8(3), ytae119, Mar. 2024
Lead

Impact of Low Bone Mineral Content Index on Cardiovascular Outcomes in Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention.
Tadashi Itagaki; Yasushi Ueki; Daisuke Sunohara; Moeko Aoki; Fumika Nomoto; Toshifumi Takamatsu; Tomoaki Mochidome; Takashi Miura; Toshio Kasai; Koichiro Kuwahara; Uichi Ikeda
Angiology, 33197231226348-33197231226348, Jan. 2024
Lead

Prognostic Impact of the Ratio of Hemoglobin to Red Blood Cell Distribution Width in Patients after Acute Decompensated Heart Failure
Yusuke Kanzaki; Masatoshi Minamisawa; Hirohiko Motoki; Sho Suzuki; Yukari Okuma; Masafumi Kanai; Keisuke Machida; Kazuhiro Kimura; Yasushi Ueki; Koji Yoshie; Yasutaka Oguchi; Tamon Kato; Tatsuya Saigusa; Soichiro Ebisawa; Ayako Okada; Koichiro Kuwahara
Internal Medicine, 2024
Lead

Successful Management of a Pregnant Patient with Danon Cardiomyopathy.
Wataru Inoue; Hirohiko Motoki; Koji Yoshie; Koichiro Kuwahara
Internal medicine (Tokyo, Japan), 63(5), 681-686, 2024
Lead

Clinical Profile and Prognosis of Dementia in Patients With Acute Decompensated Heart Failure - From the CURE-HF Registry.
Keisuke Machida; Masatoshi Minamisawa; Hirohiko Motoki; Kanako Teramoto; Yukari Okuma; Masafumi Kanai; Kazuhiro Kimura; Takahiro Okano; Yasushi Ueki; Koji Yoshie; Tamon Kato; Tatsuya Saigusa; Soichiro Ebisawa; Ayako Okada; Koichiro Kuwahara
Circulation journal : official journal of the Japanese Circulation Society, 88(1), 93-102, Dec. 2023
Lead

Efficacy and Safety of Esaxerenone in Hypertensive Patients with Diabetes Mellitus Undergoing Treatment with Sodium-Glucose Cotransporter 2 Inhibitors (EAGLE-DH).
Hirohiko Motoki; Yoshito Inobe; Toshiki Fukui; Arata Iwasaki; Shinya Hiramitsu; Sekiya Koyama; Izuru Masuda; Noriyuki Sekimura; Kazuya Yamamoto; Ai Sato; Mitsuhisa Komatsu; Takashi Taguchi; Kazuhito Shiosakai; Kotaro Sugimoto; Koichiro Kuwahara
Advances in therapy, 40(11), 5055-5075, Nov. 2023
Lead

Recommendation for Appropriate Use of Sodium Glucose Cotransporter 2 Inhibitors in Treatment of Heart Failure.
Atsushi Tanaka; Koichiro Kinugawa; Koichiro Kuwahara; Hiroshi Ito; Toyoaki Murohara; Ken-Ichi Hirata; Koichi Node
Circulation journal : official journal of the Japanese Circulation Society, 87(11), 1707-1709, Oct. 2023
Lead

Real-world Practical Experience of Angiotensin Receptor-neprilysin Inhibitor in Older Japanese Patients with Chronic Heart Failure.
Toshinori Komatsu; Masatoshi Minamisawa; Ayako Okada; Hirohiko Motoki; Toshio Kasai; Koichiro Kuwahara; Uichi Ikeda
JMA journal, 6(4), 489-498, Oct. 2023
Lead

Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin.
Yuki Tanaka; Shin Kadota; Jian Zhao; Hideki Kobayashi; Satomi Okano; Masaki Izumi; Yusuke Honda; Hajime Ichimura; Naoko Shiba; Takeshi Uemura; Yuko Wada; Shinichiro Chuma; Tsutomu Nakada; Shugo Tohyama; Keiichi Fukuda; Mitsuhiko Yamada; Tatsuichiro Seto; Koichiro Kuwahara; Yuji Shiba
Stem cell research & therapy, 14(1), 240-240, Sep. 2023, Refereed
Lead

Clinical utility of urinary mulberry bodies/cells testing in the diagnosis of Fabry disease.
Katsuya Nakamura; Saki Mukai; Yuka Takezawa; Yuika Natori; Akari Miyazaki; Yuichiro Ide; Mayu Takebuchi; Kana Nanato; Mizuki Katoh; Harue Suzuki; Akiko Sakyu; Tomomi Kojima; Emiko Kise; Hiroaki Hanafusa; Tomoki Kosho; Koichiro Kuwahara; Yoshiki Sekijima
Molecular genetics and metabolism reports, 36, 100983-100983, Sep. 2023
Lead

The characteristics and outcomes in patients with acute heart failure who used tolvaptan: from KCHF registry.
Ryusuke Nishikawa; Takao Kato; Takeshi Morimoto; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Erika Yamamoto; Neiko Ozasa; Tomohisa Tada; Hiroki Sakamoto; Yuta Seko; Masayuki Shiba; Yusuke Yoshikawa; Yugo Yamashita; Takeshi Kitai; Ryoji Taniguchi; Moritake Iguchi; Kazuya Nagao; Takafumi Kawai; Akihiro Komasa; Yuichi Kawase; Takashi Morinaga; Mamoru Toyofuku; Yutaka Furukawa; Kenji Ando; Kazushige Kadota; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
ESC heart failure, 10(5), 3141-3151, Sep. 2023, Refereed, Not invited
Lead

Association between complete revascularization of the coronary artery and clinical outcomes in peripheral artery disease: a sub-analysis of the I-PAD Nagano registry.
Tamon Kato; Yasushi Ueki; Masatoshi Minamisawa; Takashi Miura; Yushi Oyama; Naoto Hashizume; Daisuke Yokota; Minami Taki; Keisuke Senda; Yoshiteru Okina; Tadamasa Wakabayashi; Koki Fujimori; Kenichi Karube; Takahiro Sakai; Hidetomo Nomi; Hisanori Yui; Yusuke Kanzaki; Keisuke Machida; Shusaku Maruyama; Ayumu Nagae; Tatsuya Saigusa; Soichiro Ebisawa; Ayako Okada; Hirohiko Motoki; Koichiro Kuwahara
Heart and vessels, 38(8), 1001-1008, Aug. 2023
Lead

Symptom-based portopulmonary hypertension screening questionnaire in Japanese patients with chronic liver disease.
Shun-Ichi Wakabayashi; Satoru Joshita; Kazuhiro Kimura; Hirohiko Motoki; Taiki Okumura; Hiroyuki Kobayashi; Yuki Yamashita; Ayumi Sugiura; Tomoo Yamazaki; Takefumi Kimura; Koichiro Kuwahara; Takeji Umemura
JGH open : an open access journal of gastroenterology and hepatology, 7(8), 527-536, Aug. 2023, Refereed
Lead

Prognostic Impact of Hyperpolypharmacy Due to Noncardiovascular Medications in Patients After Acute Decompensated Heart Failure - Insights From the Clue of Risk Stratification in the Elderly Patients With Heart Failure (CURE-HF) Registry.
Masafumi Kanai; Masatoshi Minamisawa; Hirohiko Motoki; Yuta Seko; Kazuhiro Kimura; Takahiro Okano; Yasushi Ueki; Koji Yoshie; Tamon Kato; Tatsuya Saigusa; Soichiro Ebisawa; Ayako Okada; Neiko Ozasa; Takao Kato; Koichiro Kuwahara
Circulation journal : official journal of the Japanese Circulation Society, 88(1), 33-42, Aug. 2023, Refereed, Not invited
Lead

Utility of a multipurpose catheter for transvenous extraction of old broken leads: A novel technique for fragile leads.
Ayako Okada; Satoshi Higuchi; Morio Shoda; Hiroaki Tabata; Shohei Kataoka; Wataru Shoin; Hideki Kobayashi; Takahiro Okano; Koji Yoshie; Ken Kato; Tatsuya Saigusa; Soichiro Ebisawa; Hirohiko Motoki; Koichiro Kuwahara
Heart rhythm, 20(7), 976-981, Jul. 2023
Lead

遺伝性鉄芽球性貧血、続発性鉄過剰症に合併した肺高血圧症の一例
太田 優雅子; 木下 秀之; 牧山 武; 福田 祐紀; 金森 敬彦; 柳澤 洋; 森内 健史; 稲住 英明; 塩見 紘樹; 中川 靖章; 桑原 宏一郎
日本肺高血圧・肺循環学会学術集会抄録集, 8回, 78-78, Jun. 2023
Lead

肺動脈性肺高血圧症の病態形成におけるCNP-GC-B系の意義
柳澤 洋; 中川 靖章; 金森 敬彦; 森内 健史; 稲住 英明; 木下 秀之; 錦見 俊雄; 桑原 宏一郎; 中尾 一和
日本内分泌学会雑誌, 99(1), 289-289, May 2023
Lead

Natriuretic peptides: role in the diagnosis and management of heart failure: a scientific statement from the Heart Failure Association of the European Society of Cardiology, Heart Failure Society of America and Japanese Heart Failure Society.
Hiroyuki Tsutsui; Nancy M Albert; Andrew J S Coats; Stefan D Anker; Antoni Bayes-Genis; Javed Butler; Ovidiu Chioncel; Christopher R Defilippi; Mark H Drazner; G Michael Felker; Gerasimos Filippatos; Mona Fiuzat; Tomomi Ide; James L Januzzi Jr; Koichiro Kinugawa; Koichiro Kuwahara; Yuya Matsue; Robert J Mentz; Marco Metra; Ambarish Pandey; Giuseppe Rosano; Yoshihiko Saito; Yasushi Sakata; Naoki Sato; Petar M Seferovic; John Teerlink; Kazuhiro Yamamoto; Michihiro Yoshimura
European journal of heart failure, 25(5), 616-631, May 2023
Lead

Natriuretic Peptides: Role in the Diagnosis and Management of Heart Failure: A Scientific Statement From the Heart Failure Association of the European Society of Cardiology, Heart Failure Society of America and Japanese Heart Failure Society.
Hiroyuki Tsutsui; Nancy M Albert; Andrew J S Coats; Stefan D Anker; Antoni Bayes-Genis; Javed Butler; Ovidiu Chioncel; Christopher R Defilippi; Mark H Drazner; G Michael Felker; Gerasimos Filippatos; Mona Fiuzat; Tomomi Ide; James L Januzzi Jr; Koichiro Kinugawa; Koichiro Kuwahara; Yuya Matsue; Robert J Mentz; Marco Metra; Ambarish Pandey; Giuseppe Rosano; Yoshihiko Saito; Yasushi Sakata; Naoki Sato; Petar M Seferovic; John Teerlink; Kazuhiro Yamamoto; Michihiro Yoshimura
Journal of cardiac failure, 29(5), 787-804, May 2023
Lead

Heterogeneity in characteristics and outcomes of patients who met the indications for vericiguat approved by the Japanese agency: from the KCHF registry.
Masayuki Shiba; Takao Kato; Takeshi Morimoto; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Yuta Seko; Erika Yamamoto; Yusuke Yoshikawa; Takeshi Kitai; Yugo Yamashita; Moritake Iguchi; Kazuya Nagao; Yuichi Kawase; Takashi Morinaga; Mamoru Toyofuku; Yutaka Furukawa; Kenji Ando; Kazushige Kadota; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
Journal of cardiac failure, 29(6), 976-978, Apr. 2023
Lead

Prevention of Contrast-Induced Nephropathy After Emergency Percutaneous Coronary Intervention With a Single Bolus Administration of High-Concentrate Sodium Bicarbonate ― Rationale and Design of a Single-Arm Study Compared With Historical Controls ―
Takuya Nakamura; Makoto Watanabe; Kazutaka Nogi; Takaaki Kosugi; Yukihiro Hashimoto; Tomoya Ueda; Naofumi Doi; Hiroyuki Kawata; Manabu Horii; Kenichi Ishigami; Tamio Nakajima; Hiroaki Watabe; Daisuke Abe; Koichiro Kuwahara; Yasuo Okumura; Naoki Ozu; Shota Suzuki; Shu Kasama; Yoshihiko Saito
Circulation Reports, 5(4), 152-156, Apr. 2023, Refereed
Lead

Periprocedural myocardial infarction in patients undergoing percutaneous coronary intervention.
Yasushi Ueki; Koichiro Kuwahara
Journal of cardiology, 81(4), 364-372, Apr. 2023
Lead

Tricuspid regurgitation in elderly patients with acute heart failure: insights from the KCHF registry.
Yuki Obayashi; Takao Kato; Hidenori Yaku; Takeshi Morimoto; Yuta Seko; Yasutaka Inuzuka; Yodo Tamaki; Erika Yamamoto; Yusuke Yoshikawa; Takeshi Kitai; Ryoji Taniguchi; Moritake Iguchi; Masashi Kato; Mamoru Takahashi; Toshikazu Jinnai; Tomoyuki Ikeda; Kazuya Nagao; Takafumi Kawai; Akihiro Komasa; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Kanae Su; Mitsunori Kawato; Moriaki Inoko; Mamoru Toyofuku; Yutaka Furukawa; Yoshihisa Nakagawa; Kenji Ando; Kazushige Kadota; Satoshi Shizuta; Koh Ono; Yukihito Sato; Koichiro Kuwahara; Neiko Ozasa; Takeshi Kimura
ESC heart failure, 10(3), 1948-1960, Mar. 2023
Lead

JCS 2023 Guideline on the Diagnosis and Treatment of Myocarditis.
Toshiyuki Nagai; Takayuki Inomata; Takashi Kohno; Takuma Sato; Atsushi Tada; Toru Kubo; Kazufumi Nakamura; Noriko Oyama-Manabe; Yoshihiko Ikeda; Takeo Fujino; Yasuhide Asaumi; Takahiro Okumura; Toshiyuki Yano; Kazuko Tajiri; Hiroyuki Matsuura; Yuichi Baba; Haruki Sunami; Shingo Tsujinaga; Yasutoshi Ota; Keiko Ohta-Ogo; Yusuke Ishikawa; Hideo Matama; Nobutaka Nagano; Kimi Sato; Kazushi Yasuda; Yasushi Sakata; Koichiro Kuwahara; Tohru Minamino; Minoru Ono; Toshihisa Anzai
Circulation journal : official journal of the Japanese Circulation Society, 87(5), 674-754, Mar. 2023, Refereed
Lead

A Multicenter Prospective Interventional Trial of Therapeutic Angiogenesis Using Bone Marrow-Derived Mononuclear Cell Implantation for Patients With Critical Limb-Threatening Ischemia Caused by Thromboangiitis Obliterans.
Ayumu Fujioka; Kenji Yanishi; Arito Yukawa; Kojiro Imai; Isao Yokota; Kei Fujikawa; Ayumu Yamada; Akari Naito; Keisuke Shoji; Hirofumi Kawamata; Yukihito Higashi; Tomoaki Ishigami; Ken-Ichiro Sasaki; Syuhei Tara; Koichiro Kuwahara; Satoshi Teramukai; Satoaki Matoba
Circulation journal : official journal of the Japanese Circulation Society, 87(9), 1229-1237, Mar. 2023, Refereed
Lead

転写抑制因子NRSFを介した心不全進展の分子メカニズム
稲住 英明; 桑原 宏一郎; 中川 靖章; 大矢 未来; 木下 秀之; 森内 健司; 柳澤 洋; 金森 敬彦; 錦見 俊雄; 中尾 一和
日本内分泌学会雑誌, 98(5), 1565-1565, Mar. 2023
Lead

TRPC3/6の阻害はげっ歯類の肺動脈性肺高血圧症を改善する(Inhibition of TRPC3/6 Ameliorates Pulmonary Arterial Hypertension in Rodents)
Moriuchi Kenji; Nakagawa Yasuaki; Kinoshita Hideyuki; Inazumi Hideaki; Yanagisawa Hiromu; Kanamori Takahiko; Nishikimi Toshio; Oya Miku; Nishida Motohiro; Mori Yasuo; Nagata Ryu; Nakamura Kazufumi; Kuwahara Koichiro; Nakao Kazuwa; Kimura Takeshi
日本循環器学会学術集会抄録集, 87回, YIA-4, Mar. 2023
Lead

Association between changes in loop diuretic dose and outcomes in acute heart failure.
Yuta Seko; Takao Kato; Takeshi Morimoto; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Masayuki Shiba; Erika Yamamoto; Yusuke Yoshikawa; Yugo Yamashita; Takeshi Kitai; Ryoji Taniguchi; Moritake Iguchi; Kazuya Nagao; Takafumi Kawai; Akihiro Komasa; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Mamoru Toyofuku; Yutaka Furukawa; Kenji Ando; Kazushige Kadota; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
ESC heart failure, E-pub(3), 1757-1770, Mar. 2023, Refereed, Not invited
Lead

Rationale and Study design of the GOREISAN for Heart Failure (GOREISAN-HF) trial: A randomized clinical trial.
Hidenori Yaku; Takao Kato; Takeshi Morimoto; Kazuhisa Kaneda; Ryusuke Nishikawa; Takeshi Kitai; Yasutaka Inuzuka; Yodo Tamaki; Taketoshi Yamazaki; Jun Kitamura; Hirotaka Ezaki; Kazuya Nagao; Hiromi Yamamoto; Akihiro Isotani; Arita Takeshi; Chisato Izumi; Yukihito Sato; Yoshihisa Nakagawa; Satoaki Matoba; Yasushi Sakata; Koichiro Kuwahara; Takeshi Kimura
American heart journal, 260, 18-25, Feb. 2023, Refereed
Lead

Prognostic value of the severity of clinical congestion in patients hospitalized for decompensated heart failure: Findings from the Japanese KCHF registry.
Kenji Aida; Kazuya Nagao; Takao Kato; Hidenori Yaku; Takeshi Morimoto; Yasutaka Inuzuka; Yodo Tamaki; Erika Yamamoto; Yusuke Yoshikawa; Takeshi Kitai; Ryoji Taniguchi; Moritake Iguchi; Masashi Kato; Mamoru Takahashi; Toshikazu Jinnai; Takafumi Kawai; Akihiro Komasa; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Kanae Su; Mitsunori Kawato; Yuta Seko; Tsukasa Inada; Moriaki Inoko; Mamoru Toyofuku; Yutaka Furukawa; Yoshihisa Nakagawa; Kenji Ando; Kazushige Kadota; Satoshi Shizuta; Koh Ono; Yukihito Sato; Koichiro Kuwahara; Neiko Ozasa; Takeshi Kimura
Journal of cardiac failure, 29(8), 1150-1162, Jan. 2023
Lead

肺高血圧症の発症におけるCNP-GC-B系の重要な役割(Importance of the CNP-GC-B system in the development of pulmonary hypertension)
柳澤 洋; 金森 敬彦; 森内 健史; 稲住 英明; 錦見 俊雄; 中川 靖章; 桑原 宏一郎
血管, 46(1), 45-45, Jan. 2023
Lead

Weight loss during follow-up in patients with acute heart failure: From the KCHF registry.
Yuta Seko; Takao Kato; Takeshi Morimoto; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Masayuki Shiba; Erika Yamamoto; Yusuke Yoshikawa; Takeshi Kitai; Yugo Yamashita; Moritake Iguchi; Kazuya Nagao; Yuichi Kawase; Takashi Morinaga; Mamoru Toyofuku; Yutaka Furukawa; Kenji Ando; Kazushige Kadota; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
PloS one, 18(6), e0287637, 2023
Lead

Intracoronary transplantation of pluripotent stem cell-derived cardiomyocytes: Inefficient procedure for cardiac regeneration.
Hideki Kobayashi; Shugo Tohyama; Hideaki Kanazawa; Hajime Ichimura; Shuji Chino; Yuki Tanaka; Yota Suzuki; Jian Zhao; Naoko Shiba; Shin Kadota; Kazumasa Narita; Takafumi Naito; Tatsuichiro Seto; Koichiro Kuwahara; Yuji Shiba; Keiichi Fukuda
Journal of molecular and cellular cardiology, 174, 77-87, Nov. 2022, Refereed
Lead

Association of intravenous heparin administration with in-hospital clinical outcomes among hospitalized patients with acute heart failure.
Yasuhiro Hamatani; Takao Kato; Takeshi Morimoto; Moritake Iguchi; Hidenori Yaku; Yasutaka Inuzuka; Takeshi Kitai; Kazuya Nagao; Yodo Tamaki; Erika Yamamoto; Neiko Ozasa; Yugo Yamashita; Mitsuru Abe; Yukihito Sato; Koichiro Kuwahara; Masaharu Akao; Takeshi Kimura
International journal of cardiology, 370, 229-235, Nov. 2022, Refereed
Lead

Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors.
Sayaka Oda; Kazuhiro Nishiyama; Yuka Furumoto; Yohei Yamaguchi; Akiyuki Nishimura; Xiaokang Tang; Yuri Kato; Takuro Numaga-Tomita; Toshiyuki Kaneko; Supachoke Mangmool; Takuya Kuroda; Reishin Okubo; Makoto Sanbo; Masumi Hirabayashi; Yoji Sato; Yasuaki Nakagawa; Koichiro Kuwahara; Ryu Nagata; Gentaro Iribe; Yasuo Mori; Motohiro Nishida
Nature communications, 13(1), 6374-6374, Oct. 2022, Refereed
Lead

A comparison between hospital follow-up and collaborative follow-up in patients with acute heart failure.
Koichi Washida; Takao Kato; Neiko Ozasa; Takeshi Morimoto; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Yuta Seko; Erika Yamamoto; Yusuke Yoshikawa; Masayuki Shiba; Takeshi Kitai; Yugo Yamashita; Ryoji Taniguchi; Moritake Iguchi; Kazuya Nagao; Yuichi Kawase; Yuji Nishimoto; Takashi Kuragaichi; Kozo Hotta; Takashi Morinaga; Mamoru Toyofuku; Yutaka Furukawa; Kenji Ando; Kazushige Kadota; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
ESC heart failure, 10(1), 353-365, Oct. 2022, Refereed
Lead

Prevention of Contrast-Induced Nephropathy After Cardiovascular Catheterization and Intervention With High-Dose Strong Statin Therapy in Japan ― The PREVENT CINC-J Study ―
Makoto Watanabe; Kazutaka Aonuma; Toyoaki Murohara; Yasuo Okumura; Takeshi Morimoto; Sadanori Okada; Sunao Nakamura; Shiro Uemura; Koichiro Kuwahara; Tadateru Takayama; Naofumi Doi; Tamio Nakajima; Manabu Horii; Kenichi Ishigami; Kazumiki Nomoto; Daisuke Abe; Koji Oiwa; Kentaro Tanaka; Terumasa Koyama; Akira Sato; Tomoya Ueda; Tsunenari Soeda; Yoshihiko Saito
Circulation Journal, 86(9), 1455-1463, Aug. 2022
Lead

積極的治療の功罪の罪～こんなケースは慎重に治療しよう 経過中に肺高血圧治療薬の併用が困難となったSSc合併PAHの症例
嶋本 光兵; 木下 秀之; 吉藤 元; 柳澤 洋; 森内 健史; 稲住 英明; 堀江 貴裕; 中川 靖章; 桑原 宏一郎; 木村 剛
日本肺高血圧・肺循環学会学術集会・日本小児肺循環研究会プログラム・抄録集, 7回・28回, 109-109, Jul. 2022
Lead

神経線維腫症1型に合併した肺高血圧症の1例
崎山 智基; 三浦 優人; 木下 秀之; 嶋本 光兵; 柳澤 洋; 森内 健史; 稲住 英明; 堀江 貴裕; 中川 靖章; 桑原 宏一郎; 木村 剛
日本肺高血圧・肺循環学会学術集会・日本小児肺循環研究会プログラム・抄録集, 7回・28回, 157-157, Jul. 2022
Lead

肺疾患合併PAHに対する経口IP受容体作動薬の使用経験
中井 久登; 木下 秀之; 柳澤 洋; 森内 健史; 稲住 英明; 堀江 貴裕; 中川 靖章; 桑原 宏一郎; 木村 剛
日本肺高血圧・肺循環学会学術集会・日本小児肺循環研究会プログラム・抄録集, 7回・28回, 160-160, Jul. 2022
Lead

大腿骨頸部骨折を契機に脂肪塞栓症を来したSSc-PHの一例
中 美咲; 三浦 優人; 木下 秀之; 中川 靖章; 渡部 宏俊; 柳澤 洋; 稲住 英明; 半田 知宏; 吉藤 元; 桑原 宏一郎; 木村 剛
日本肺高血圧・肺循環学会学術集会・日本小児肺循環研究会プログラム・抄録集, 7回・28回, 162-162, Jul. 2022
Lead

Insomnia in patients with acute heart failure: from the KCHF registry
Yuta Seko; Erika Yamamoto; Takao Kato; Takeshi Morimoto; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Masayuki Shiba; Yusuke Yoshikawa; Yugo Yamashita; Takeshi Kitai; Ryoji Taniguchi; Moritake Iguchi; Kazuya Nagao; Takafumi Kawai; Akihiro Komasa; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Mamoru Toyofuku; Yutaka Furukawa; Kenji Ando; Kazushige Kadota; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
ESC Heart Failure, 9(5), 2988-2996, Jun. 2022
Lead

Public assistance in patients with acute heart failure: a report from the KCHF registry
Yuji Nishimoto; Takao Kato; Takeshi Morimoto; Ryoji Taniguchi; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Erika Yamamoto; Yusuke Yoshikawa; Takeshi Kitai; Moritake Iguchi; Masashi Kato; Mamoru Takahashi; Toshikazu Jinnai; Tomoyuki Ikeda; Kazuya Nagao; Takafumi Kawai; Akihiro Komasa; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Kanae Su; Mitsunori Kawato; Yuta Seko; Moriaki Inoko; Mamoru Toyofuku; Yutaka Furukawa; Yoshihisa Nakagawa; Kenji Ando; Kazushige Kadota; Satoshi Shizuta; Koh Ono; Koichiro Kuwahara; Neiko Ozasa; Yukihito Sato; Takeshi Kimura
ESC Heart Failure, 9(3), 1920-1930, Jun. 2022, Refereed
Lead

Infective endocarditis caused by Streptococcus pneumoniae from sinusitis: A case report.
Ken Yamazaki; Takashi Miura; Daisuke Sunohara; Toshinori Komatsu; Tomoaki Mochidome; Toshio Kasai; Uichi Ikeda; Koichiro Kuwahara
Journal of cardiology cases, 25(5), 279-281, May 2022
Lead

拡張型心筋症モデルマウスを用いた心腎連関の機序解明
石村 拓也; 石井 輝; 山田 博之; 中川 靖章; 大野 祥子; 生島 昭恵; 杉岡 清香; 半田 貴也; 桑原 宏一郎; 柳田 素子; 横井 秀基
日本腎臓学会誌, 64(3), 318-318, May 2022
Lead

Gender difference in heart failure with preserved ejection fraction: clinical profiles, examinations, and prognosis.
Takahiro Sakai; Hirohiko Motoki; Sho Suzuki; Aya Fuchida; Takahiro Takeuchi; Kyuhachi Otagiri; Masafumi Kanai; Kazuhiro Kimura; Masatoshi Minamisawa; Koji Yoshie; Tatsuya Saigusa; Soichiro Ebisawa; Ayako Okada; Hiroshi Kitabayashi; Koichiro Kuwahara
Heart and vessels, 37(10), 1710-1718, Apr. 2022
Lead

Intensive exercise therapy for restenosis after superficial femoral artery stenting: the REASON randomized clinical trial.
Tamon Kato; Takashi Miura; Shuhei Yamamoto; Yusuke Miyashita; Naoto Hashizume; Kyoko Shoin; Shinya Sasaki; Yusuke Kanzaki; Hisanori Yui; Shusaku Maruyama; Ayumu Nagae; Takahiro Sakai; Tatsuya Saigusa; Soichiro Ebisawa; Ayako Okada; Hirohiko Motoki; Uichi Ikeda; Koichiro Kuwahara
Heart and vessels, 37(9), 1596-1603, Apr. 2022, Refereed
Lead

Left atrial reverse remodeling improves risk stratification in patients with heart failure with recovered ejection fraction.
Masayuki Shiba; Takao Kato; Takeshi Morimoto; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Yuta Seko; Erika Yamamoto; Yusuke Yoshikawa; Takeshi Kitai; Yugo Yamashita; Moritake Iguchi; Kazuya Nagao; Yuichi Kawase; Takashi Morinaga; Mamoru Toyofuku; Yutaka Furukawa; Kenji Ando; Kazushige Kadota; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
Scientific reports, 12(1), 4473-4473, Mar. 2022
Lead

Starting Neurohormonal Antagonists in Patients With Acute Heart Failure With Mid-Range and Preserved Ejection Fraction.
Yuta Seko; Takao Kato; Takeshi Morimoto; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Masayuki Shiba; Erika Yamamoto; Yusuke Yoshikawa; Yugo Yamashita; Takeshi Kitai; Ryoji Taniguchi; Moritake Iguchi; Kazuya Nagao; Takafumi Kawai; Akihiro Komasa; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Mamoru Toyofuku; Yutaka Furukawa; Kenji Ando; Kazushige Kadota; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
Circulation journal : official journal of the Japanese Circulation Society, 86(10), 1547-1558, Feb. 2022, Refereed
Lead

肺動脈性肺高血圧症の発症・進展におけるTRPC6/3およびCNP経路の意義
木下 秀之; 柳澤 洋; 森内 健史; 稲住 英明; 中川 靖章; 桑原 宏一郎
循環器内科, 91(2), 221-225, Feb. 2022
Lead

【循環器疾患におけるレニン・アンジオテンシン・アルドステロン(RAA)系の新たな展望】心血管病におけるRAA系の意識を再考する
桑原 宏一郎; 斎藤 能彦; 吉村 道博; 下澤 達雄
Cardiac Practice, 32(2), 135-141, Feb. 2022
Lead

Current use of inotropes according to initial blood pressure and peripheral perfusion in the treatment of congestive heart failure: findings from a multicentre observational study.
Kazuya Nagao; Takao Kato; Hidenori Yaku; Takeshi Morimoto; Yasutaka Inuzuka; Yodo Tamaki; Erika Yamamoto; Yusuke Yoshikawa; Takeshi Kitai; Ryoji Taniguchi; Moritake Iguchi; Masashi Kato; Mamoru Takahashi; Toshikazu Jinnai; Tomoyuki Ikeda; Takafumi Kawai; Akihiro Komasa; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Kanae Su; Mitsunori Kawato; Yuta Seko; Tsukasa Inada; Moriaki Inoko; Mamoru Toyofuku; Yutaka Furukawa; Yoshihisa Nakagawa; Kenji Ando; Kazushige Kadota; Satoshi Shizuta; Koh Ono; Yukihito Sato; Koichiro Kuwahara; Neiko Ozasa; Takeshi Kimura
BMJ open, 12(1), e053254, Jan. 2022
Lead

Polypharmacy and Clinical Outcomes in Hospitalized Patients With Acute Decompensated Heart Failure.
Neiko Ozasa; Takao Kato; Takeshi Morimoto; Hidenori Yaku; Erika Yamamoto; Yasutaka Inuzuka; Yodo Tamaki; Takeshi Kitai; Koichi Washida; Yuta Seko; Yusuke Yoshikawa; Yukihito Sato; Hirohiko Motoki; Koichiro Kuwahara; Takeshi Kimura
The Journal of cardiovascular nursing, Jan. 2022
Lead

Effects of cardiac surgical support on long-term outcomes of emergent or complex percutaneous coronary intervention cases: a sub-analysis of the SHINANO 5-year registry
Chie Nakamura; Soichiro Ebisawa; Takashi Miura; Hidetomo Nomi; Yusuke Kanzaki; Hisanori Yui; Shusaku Maruyama; Ayumu Nagae; Yasushi Ueki; Takahiro Sakai; Tamon Kato; Tatsuya Saigusa; Ayako Okada; Hirohiko Motoki; Koichiro Kuwahara
HEART AND VESSELS, 37(7), 1106-1114, Jan. 2022
Lead

Comparison of prognostic impact of anticoagulants in heart failure patients with atrial fibrillation and renal dysfunction: direct oral anticoagulants versus vitamin K antagonists
Takahiro Sakai; Hirohiko Motoki; Aya Fuchida; Takahiro Takeuchi; Kyuhachi Otagiri; Masafumi Kanai; Kazuhiro Kimura; Masatoshi Minamisawa; Koji Yoshie; Tatsuya Saigusa; Soichiro Ebisawa; Ayako Okada; Hiroshi Kitabayashi; Koichiro Kuwahara
HEART AND VESSELS, Jan. 2022
Lead

神経体液性因子抑制の新しい展開 : ARNIおよび新世代MRA
桑原 宏一郎
Heart View, 26(1), 68-74, Jan. 2022

Appetite loss at discharge from acute decompensated heart failure: Observation from KCHF registry.
Erika Yamamoto; Takao Kato; Hidenori Yaku; Takeshi Morimoto; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Yusuke Yoshikawa; Takeshi Kitai; Ryoji Taniguchi; Moritake Iguchi; Masashi Kato; Mamoru Takahashi; Toshikazu Jinnai; Tomoyuki Ikeda; Kazuya Nagao; Takafumi Kawai; Akihiro Komasa; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Mitsunori Kawato; Yuta Seko; Masayuki Shiba; Mamoru Toyofuku; Yutaka Furukawa; Yoshihisa Nakagawa; Kenji Ando; Kazushige Kadota; Satoshi Shizuta; Koh Ono; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
PloS one, 17(5), e0267327, 2022
Lead

Changes in BNP levels from discharge to 6-month visit predict subsequent outcomes in patients with acute heart failure.
Masayuki Shiba; Takao Kato; Takeshi Morimoto; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Yuta Seko; Erika Yamamoto; Yusuke Yoshikawa; Takeshi Kitai; Yugo Yamashita; Moritake Iguchi; Kazuya Nagao; Yuichi Kawase; Takashi Morinaga; Mamoru Toyofuku; Yutaka Furukawa; Kenji Ando; Kazushige Kadota; Yukihito Sato; Yasuaki Nakagawa; Koichiro Kuwahara; Takeshi Kimura
PloS one, 17(1), e0263165, 2022
Lead

Gigantic Pacemaker Pocket Abscess Infected by Staphylococcus epidermidis
Okano T, Okada A, Shoda M, Kuwahara K
Intern Med, 61(4), 593-594, 2022

Successful endovascular treatment with a stent graft for chronic deep vein thrombosis with multiple arteriovenous fstulas: a case report
Kato T, Fuke M, Nagai F, Nomi H, Kanzaki Y, Yui H, Maruyama S, Nagae A, Sakai T, Saigusa T, Ebisawa S, Okada A, Motoki H, Kuwahara K
J Med Case Rep, 16(1), 257, 2022

Cilostazol effectiveness in reducing drugcoated stent restenosis in the superficial femoral artery: The ZERO study
Miura T, Miyashita Y, Hozawa K, Doijiri T, Kato T, Hayakawa N, Hashizume N, Nakano M, Ikeda U, Kuwahara K, on behalf of the ZERO Investigators
PLOS ONE, 17(7), e0270992, 2022

Usefulness of the controlled-rotation dilator sheath “Evolution RL” for extraction of old leads in two Japanese centers – An experience in use
Tabata H, Okada A, Kobayashi H, Shoin W, Okano T, Higuchi S, Yagishita D, Ebisawa S, Motoki H, Shoda M, Kuwahara K
J Cardiol, 80(4), 339-343, 2022

The Impact of Hyperuricemia on Patients With Low Body Mass Index After Endovascular Treatments: Data From the I-PAD Registry
Nagae A, Ebisawa S, Saigusa T, Nishikawa K, Fujimori K, Yui H, Maruyama S, Nakamura C, Kashiwagi D, Kobayashi H, Sakai T, Senda K, Kato T, Miura T, Okada A, Motoki H, Kuwahara K
Angiology, 73(8), 753-763, 2022

Impact of Frailty and Age on Clinical Outcomes in Patients Who Underwent Endovascular Therapy
Nishikawa K, Ebisawa S, Miura T, Kato T, Kanzaki Y, Abe N, Yokota D, Yanagisawa T, Senda K, Wakabayashi T, Oyama Y, Karube K, Itagaki T, Yui H, Maruyama S, Nagae A, Sakai T, Okina Y, Nakazawa S, Tsukada S, Saigusa T, Okada A, Motoki H, Kagoshima M, Kuwahara K
J Endovasc Ther, 29(6), 845-854, 2022

NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca2+ Homeostasis
Inazumi H, Kuwahara K, Nakagawa Y, Kuwabara Y, Numaga-Tomita T, Kashihara T, Nakada T, Kurebayashi N, Oya M, Nonaka M, Sugihara M, Kinoshita H, Moriuchi K, Yanagisawa H, Nishikimi T, Motoki H, Yamada M, Morimoto S, Otsu K, Mortensen RM, Nakao K, Kimura T
Circ Res, 130(2), 234-248, 2022

Coronary angiography in patients with acute heart failure: from the KCHF registry
Seko Y, Kishimori T, Kato T, Morimoto T, Yaku H, Inuzuka Y, Tamaki Y, Ozasa N, Shiba M, Yamamoto E, Yoshikawa Y, Yamashita Y, Kitai T, Taniguchi R, Iguchi M, Nagao K, Kawai T, Komasa A, Nishikawa R, Kawase Y, Morinaga T, Toyofuku M, Furukawa Y, Ando K, Kadota K, Sato Y, Kuwahara K, Kimura T; KCHF Study Investigators
ESC Heart Fail, 9(1), 531-544, 2022

NRSF/REST-Mediated Epigenomic Regulation in the Heart: Transcriptional Control of Natriuretic Peptides and Beyond
Inazumi H, Kuwahara K
Biology, 11(8), 1197, 2022

Therapeutic angiogenesis for patients with no-option critical limb ischemia by adipose-derived regenerative cells: TACT-ADRC multicenter trial
Shimizu Y, Kondo K, Hayashida R, Sasaki KI, Ohtsuka M, Fukumoto Y, Takashima S, Inoue O, Usui S, Takamura M, Sakuma M, Inoue T, Nagata T, Akashi YJ, Yamada Y, Kato T, Kuwahara K, Tateno K, Kobayashi Y, Shibata R, Murohara T; TACT-ADRC multicenter trial Group
Angiogenesis, 25(4), 535-546, 2022

Status of adult outpatients with congenital heart disease in Japan: The Japanese Network of Cardiovascular Departments for Adult Congenital Heart Disease Registry
Yao A, Inuzuka R, Mizuno A, Iwano H, Tatebe S, Tsukamoto Y, Sakamoto I, Watanabe H, Fukuda N, Takechi F, Adachi S, Akazawa Y, Kuwahara K, Dohi K, Ishizu T, Miyake M, Koitabashi N, Hasegawa-Tamba S, Sato S, Fujii T, Ehara E, Minamino T, Yamada H, Yamashita E, Kawamatsu N, Masuda K, Soma K, Shiraishi I, Nagai R, Niwa K; JNCVD-ACHD investigators
J Cardiol, 80(6), 525-531, 2022

NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca 2+ Homeostasis
Hideaki Inazumi; Koichiro Kuwahara; Yasuaki Nakagawa; Yoshihiro Kuwabara; Takuro Numaga-Tomita; Toshihide Kashihara; Tsutomu Nakada; Nagomi Kurebayashi; Miku Oya; Miki Nonaka; Masami Sugihara; Hideyuki Kinoshita; Kenji Moriuchi; Hiromu Yanagisawa; Toshio Nishikimi; Hirohiko Motoki; Mitsuhiko Yamada; Sachio Morimoto; Kinya Otsu; Richard M Mortensen; Kazuwa Nakao; Takeshi Kimura
Circulation Research, Dec. 2021
Lead

Body composition and mortality in patients undergoing endovascular treatment for peripheral artery disease
Tadashi Itagaki; Soichiro Ebisawa; Kyuhachi Otagiri; Tamon Kato; Takashi Miura; Yusuke Kanzaki; Naoyuki Abe; Daisuke Yokota; Takashi Yanagisawa; Keisuke Senda; Yoshiteru Okina; Tadamasa Wakabayashi; Yushi Oyama; Kenichi Karube; Keisuke Machida; Takahiro Takeuchi; Tatsuya Saigusa; Hirohiko Motoki; Hiroshi Kitabayashi; Koichiro Kuwahara
HEART AND VESSELS, 36(12), 1830-1840, Dec. 2021
Lead

Impact of Frailty and Age on Clinical Outcomes in Patients Who Underwent Endovascular Therapy
Ken Nishikawa; Soichiro Ebisawa; Takashi Miura; Tamon Kato; Kanzaki Yusuke; Naoyuki Abe; Daisuke Yokota; Takashi Yanagisawa; Keisuke Senda; Tadamasa Wakabayashi; Yushi Oyama; Kenichi Karube; Tadashi Itagaki; Hisanori Yui; Shusaku Maruyama; Ayumu Nagae; Takahiro Sakai; Yoshiteru Okina; Shun Nakazawa; Shunichi Tsukada; Tatsuya Saigusa; Ayako Okada; Hirohiko Motoki; Mitsuru Kagoshima; Koichiro Kuwahara
JOURNAL OF ENDOVASCULAR THERAPY, 29(6), 845-854, Dec. 2021
Lead

Ischemic Stroke in Acute Decompensated Heart Failure: From the KCHF Registry
Moritake Iguchi; Takao Kato; Hidenori Yaku; Takeshi Morimoto; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Erika Yamamoto; Yusuke Yoshikawa; Takeshi Kitai; Yasuhiro Hamatani; Yugo Yamashita; Nobutoyo Masunaga; Hisashi Ogawa; Mitsuru Ishii; Yoshimori An; Ryoji Taniguchi; Masashi Kato; Mamoru Takahashi; Toshikazu Jinnai; Tomoyuki Ikeda; Kazuya Nagao; Takafumi Kawai; Akihiro Komasa; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Mitsunori Kawato; Yuta Seko; Mamoru Toyofuku; Yutaka Furukawa; Kenji Ando; Kazushige Kadota; Mitsuru Abe; Masaharu Akao; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(21), Nov. 2021
Lead

The natriuretic peptide system in heart failure: Diagnostic and therapeutic implications
Koichiro Kuwahara
PHARMACOLOGY & THERAPEUTICS, 227, Nov. 2021
Lead

Newly Diagnosed Infection After Admission for Acute Heart Failure: From the KCHF Registry
Yuta Seko; Takao Kato; Takeshi Morimoto; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Masayuki Shiba; Erika Yamamoto; Yusuke Yoshikawa; Yugo Yamashita; Takeshi Kitai; Ryoji Taniguchi; Moritake Iguchi; Kazuya Nagao; Toshikazu Jinnai; Akihiro Komasa; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Mamoru Toyofuku; Yutaka Furukawa; Kenji Ando; Kazushige Kadota; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(22), e023256, Nov. 2021
Lead

Coronary angiography in patients with acute heart failure: from the KCHF registry
Yuta Seko; Takefumi Kishimori; Takao Kato; Takeshi Morimoto; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Masayuki Shiba; Erika Yamamoto; Yusuke Yoshikawa; Yugo Yamashita; Takeshi Kitai; Ryoji Taniguchi; Moritake Iguchi; Kazuya Nagao; Takafumi Kawai; Akihiro Komasa; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Mamoru Toyofuku; Yutaka Furukawa; Kenji Ando; Kazushige Kadota; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
ESC HEART FAILURE, Nov. 2021
Lead

Relationship between the flood disaster caused by the Reiwa first year east Japan typhoon and cardiovascular and cerebrovascular events in Nagano City: The SAVE trial
Daisuke Sunohara; Takashi Miura; Toshinori Komatsu; Naoto Hashizume; Tomoyasu Momose; Tsunesuke Kono; Hirohiko Motoki; Tomoaki Mochidome; Toshio Kasai; Koichiro Kuwahara; Uichi Ikeda
JOURNAL OF CARDIOLOGY, 78(5), 447-455, Nov. 2021
Lead

C型ナトリウム利尿ペプチド/GC-B系の肺高血圧症における役割
柳澤 洋; 森内 健史; 稲住 英明; 木下 秀之; 中川 靖章; 錦見 俊雄; 大矢 未来; 中尾 一和; 桑原 宏一郎; 木村 剛
日本動脈硬化学会総会プログラム・抄録集, 53回, 227-227, Oct. 2021
Lead

Successful bailout of stent graft stuck in stent occlusion lesion
Tamon Kato; Ayumu Nagae; Takahiro Sakai; Tatsuya Saigusa; Soichiro Ebisawa; Koichiro Kuwahara
CARDIOVASCULAR INTERVENTION AND THERAPEUTICS, 36(4), 535-536, Oct. 2021
Lead

Prognostic ability of mid-term worsening renal function after percutaneous coronary intervention: findings from the SHINANO registry
Yoshiteru Okina; Takashi Miura; Keisuke Senda; Minami Taki; Masanori Kobayashi; Masafumi Kanai; Yukari Okuma; Takashi Yanagisawa; Naoto Hashizume; Kyuhachi Otagiri; Kyoko Shoin; Noboru Watanabe; Soichiro Ebisawa; Kenichi Karube; Hiroyuki Nakajima; Tatsuya Saigusa; Yusuke Miyashita; Daisuke Kashiwagi; Keisuke Machida; Naoyuki Abe; Takahiro Tachibana; Yusuke Kanzaki; Takuya Maruyama; Hidetomo Nomi; Takahiro Sakai; Hisanori Yui; Tomoaki Mochidome; Takahiro Kobayashi; Toshio Kasai; Uichi Ikeda; Koichiro Kuwahara
HEART AND VESSELS, 36(10), 1496-1505, Oct. 2021
Lead

Prognostic significance of diastolic blood pressure in patients with heart failure with preserved ejection fraction
Aya Fuchida; Sho Suzuki; Hirohiko Motoki; Yusuke Kanzaki; Takuya Maruyama; Naoto Hashizume; Ayako Kozuka; Kumiko Yahikozawa; Koichiro Kuwahara
HEART AND VESSELS, 36(8), 1159-1165, Aug. 2021
Lead

Percutaneous Removal of a Displaced Inferior Vena Cava Filter Using a Loop-Wire Technique and Lead-Extraction Sheaths
Koki Fujimori; Ayako Okada; Hiroaki Tabata; Morio Shoda; Koichiro Kuwahara
CIRCULATION JOURNAL, 85(8), 1403-1403, Aug. 2021
Lead

A decrease in tricuspid regurgitation pressure gradient associates with favorable outcome in patients with heart failure
Yuta Seko; Takao Kato; Takeshi Morimoto; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Masayuki Shiba; Erika Yamamoto; Yusuke Yoshikawa; Takeshi Kitai; Yugo Yamashita; Moritake Iguchi; Kazuya Nagao; Yuichi Kawase; Takashi Morinaga; Mamoru Toyofuku; Yutaka Furukawa; Kenji Ando; Kazushige Kadota; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
ESC HEART FAILURE, 8(4), 2826-2836, Aug. 2021
Lead

Improved and new-onset anemia during follow-up in patients with acute decompensated heart failure Characteristics and outcomes
Yuta Seko; Takao Kato; Takeshi Morimoto; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Masayuki Shiba; Erika Yamamoto; Yusuke Yoshikawa; Takeshi Kitai; Yugo Yamashita; Moritake Iguchi; Kazuya Nagao; Yuichi Kawase; Takashi Morinaga; Mamoru Toyofuku; Yutaka Furukawa; Kenji Ando; Kazushige Kadota; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
MEDICINE, 100(32), e26892, Aug. 2021
Lead

Risk Factors and Clinical Outcomes of Nonhome Discharge in Patients With Acute Decompensated Heart Failure: An Observational Study
Koichi Washida; Takao Kato; Neiko Ozasa; Takeshi Morimoto; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Yuta Seko; Erika Yamamoto; Yusuke Yoshikawa; Takeshi Kitai; Yugo Yamashita; Moritake Iguchi; Kazuya Nagao; Yuichi Kawase; Takashi Morinaga; Mamoru Toyofuku; Yutaka Furukawa; Kenji Ando; Kazushige Kadota; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(15), Aug. 2021
Lead

Association between Inter-atrial Septum Motion and Persistent Atrial Fibrillation Recurrence after Catheter Ablation
Kobayashi Hideki, Okada Ayako, Tabata Hiroaki, Shoin Wataru, Okano Takahiro, Yoshie Koji, Oguchi Yasutaka, Kato Ken, Motoki Hirohiko, Shoda Morio, Kuwahara Koichiro
The Shinshu Medical Journal, 69(4), 189-201, Aug. 2021

Inflammation-based assessment for the risk stratification of mortality in patients with heart failure
Tadashi Itagaki; Hirohiko Motoki; Kyuhachi Otagiri; Keisuke Machida; Takahiro Takeuchi; Masafumi Kanai; Kazuhiro Kimura; Satoko Higuchi; Masatoshi Minamisawa; Hiroshi Kitabayashi; Koichiro Kuwahara
SCIENTIFIC REPORTS, 11(1), Jul. 2021
Lead

Admission systolic blood pressure as a prognostic predictor of acute decompensated heart failure: A report from the KCHF registry
Yuichi Kawase; Takao Kato; Takeshi Morimoto; Reo Hata; Ryosuke Murai; Takeshi Tada; Harumi Katoh; Kazushige Kadota; Erika Yamamoto; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Yusuke Yoshikawa; Moritake Iguchi; Kazuya Nagao; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
PLOS ONE, 16(7), e0253999, Jul. 2021
Lead

Early vascular response of ultra-thin bioresorbable polymer sirolimus-eluting stents assessed by optical frequency domain imaging: the EVALUATION study
Takashi Miura; Yasushi Ueki; Keisuke Senda; Kyuhachi Otagiri; Takahiro Tachibana; Tatsuya Saigusa; Soichiro Ebisawa; Hirohiko Motoki; Uichi Ikeda; Koichiro Kuwahara
CARDIOVASCULAR INTERVENTION AND THERAPEUTICS, 36(3), 281-288, Jul. 2021
Lead

Predictive Value of Abdominal Fat Distribution on Coronary Artery Disease Severity Stratified by Computed Tomography-Derived SYNTAX Score
Kyuhachi Otagiri; Keisuke Machida; Tadashi Itagaki; Takahiro Takeuchi; Yusuke Tsujinaka; Hisanori Yui; Chie Nakamura; Takahiro Sakai; Tamon Kato; Tatsuya Saigusa; Soichiro Ebisawa; Hirohiko Motoki; Koichiro Kuwahara; Hiroshi Kitabayashi
AMERICAN JOURNAL OF CARDIOLOGY, 150, 32-39, Jul. 2021
Lead

Absolute quantitative analysis of cardiac amyloidosis using SPECT/CT with Tc-99m-pyrophosphate
Shin Yanagisawa; Yusuke Takahashi; Jun Sasaki; Ken Takasone; Koji Yoshie; Jun Koyama; Nagaaki Katoh; Masahide Yazaki; Koichiro Kuwahara; Yasunari Fujinaga; Yoshiki Sekijima
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 28(3), 213-214, Jul. 2021
Lead

Lower In‐Hospital Mortality With Beta‐Blocker Use at Admission in Patients With Acute Decompensated Heart Failure
Yodo Tamaki; Hidenori Yaku; Takeshi Morimoto; Yasutaka Inuzuka; Neiko Ozasa; Erika Yamamoto; Yusuke Yoshikawa; Makoto Miyake; Hirokazu Kondo; Toshihiro Tamura; Takeshi Kitai; Moritake Iguchi; Kazuya Nagao; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Mitsunori Kawato; Mamoru Toyofuku; Yukihito Sato; Koichiro Kuwahara; Yoshihisa Nakagawa; Takao Kato; Takeshi Kimura
Journal of the American Heart Association, 10(13), Jun. 2021
Lead

ヒトES細胞由来心筋細胞は生体内で成熟した心室筋細胞に変化し移植後不整脈の抑制に関与する
市村 創; 門田 真; 桑原 宏一郎; 瀬戸 達一郎; 柴 祐司
血管, 44(1), 45-45, Jun. 2021
Lead

新規肺高血圧治療ターゲットとしてのTRPC3/C6と新規TRPC3/C6阻害剤であるL862の潜在性
森内 健史; 木下 秀之; 中川 靖章; 西田 基宏; 森 泰生; 永田 龍; 中村 一文; 錦見 俊雄; 稲住 英明; 柳澤 洋; 大矢 未来; 中尾 一和; 桑原 宏一郎; 木村 剛
血管, 44(1), 47-47, Jun. 2021
Lead

Safe and effective transvenous lead extraction for elderly patients utilizing non-laser and laser tools: a single-center experience in Japan
Ayako Okada; Hiroaki Tabata; Morio Shoda; Wataru Shoin; Hideki Kobayashi; Takahiro Okano; Koji Yoshie; Ken Kato; Tatsuya Saigusa; Soichiro Ebisawa; Hirohiko Motoki; Koichiro Kuwahara
HEART AND VESSELS, 36(6), 882-889, Jun. 2021
Lead

Multisystem Inflammatory Syndrome in Children - A New Syndrome Complicated With Acute Heart Failure Following Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection -
Momoko Uchida; Yuichiro Kashima; Katsunori Mochizuki; Hiroto Sakamoto; Kotaro Mori; Soichiro Ebisawa; Kanako Takeshige; Kenichi Nitta; Koichiro Kuwahara; Hiroshi Imamura
CIRCULATION JOURNAL, 85(6), 948-952, Jun. 2021
Lead

Serum cholinesterase as a prognostic biomarker for acute heart failure.
Masayuki Shiba; Takao Kato; Takeshi Morimoto; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Yuta Seko; Erika Yamamoto; Yusuke Yoshikawa; Takeshi Kitai; Yugo Yamashita; Moritake Iguchi; Kazuya Nagao; Yuichi Kawase; Takashi Morinaga; Mamoru Toyofuku; Yutaka Furukawa; Kenji Ando; Kazushige Kadota; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
European heart journal. Acute cardiovascular care, 10(3), 335-342, May 2021
Lead

C型ナトリウム利尿ペプチド/GC-B系の肺高血圧症における役割
柳澤 洋; 森内 健史; 稲住 英明; 木下 秀之; 中川 靖章; 錦見 俊雄; 大矢 未来; 趙 晃済; 中尾 一和; 桑原 宏一郎; 木村 剛
日本肺高血圧・肺循環学会学術集会・日本小児肺循環研究会プログラム・抄録集, 6回・27回, 67-67, May 2021
Lead

Portopulmonary Hypertensionに対する肺高血圧薬治療薬の効果
濱崎 眞希; 木下 秀之; 嶋本 光兵; 柳澤 洋; 森内 健史; 稲住 英明; 堀江 貴裕; 中川 靖章; 桑原 宏一郎; 木村 剛
日本肺高血圧・肺循環学会学術集会・日本小児肺循環研究会プログラム・抄録集, 6回・27回, 6-6, May 2021
Lead

肺高血圧治療薬開始後に消化器症状を認めたSSc合併PAHの2症例
嶋本 光兵; 木下 秀之; 吉藤 元; 柳澤 洋; 森内 健史; 稲住 英明; 堀江 貴裕; 中川 靖章; 桑原 宏一郎; 木村 剛
日本肺高血圧・肺循環学会学術集会・日本小児肺循環研究会プログラム・抄録集, 6回・27回, 9-9, May 2021
Lead

成人期に診断された動脈管開存症に伴う肺動脈性肺高血圧症の1例
嶋本 光兵; 木下 秀之; 塩見 紘樹; 柳澤 洋; 森内 健史; 稲住 英明; 堀江 貴裕; 中川 靖章; 桑原 宏一郎; 木村 剛
日本肺高血圧・肺循環学会学術集会・日本小児肺循環研究会プログラム・抄録集, 6回・27回, 19-19, May 2021
Lead

Patient Journey and Disease-Related Burden in Japanese Patients With Chronic Thromboembolic Pulmonary Hypertension: A Mixed Methods Study
Hideyuki Kinoshita; Takuya Aoki; Hirohiko Motoki; Takafumi Wakita; Yoshihiro Onishi; Emi Watanabe-Fujinuma; Koichiro Kuwahara
VALUE IN HEALTH REGIONAL ISSUES, 24, 17-23, May 2021
Lead

第三世代ミネラルコルチコイド受容体拮抗薬(MRA) (特集 新規心不全治療薬の使い方)
桑原 宏一郎;クワハラ コウイチロウ
医学のあゆみ, 277(4), 281-284, 24 Apr. 2021

肺高血圧症の発症における内皮CNP-GC-B systemの重要性(Significance of endothelial CNP-GC-B system in the development of pulmonary hypertension)
柳澤 洋; 中川 靖章; 森内 健史; 稲住 英明; 木下 秀之; 錦見 俊雄; 大矢 未来; 桑原 宏一郎; 木村 剛; 中尾 一和
日本内分泌学会雑誌, 96(4), 1109-1109, Apr. 2021
Lead

Protocol: Prospective observational study investigating the prevalence and clinical outcome of portopulmonary hypertension in Japanese patients with chronic liver disease
Shun-ichi Wakabayashi; Satoru Joshita; Kazuhiro Kimura; Hirohiko Motoki; Hiroyuki Kobayashi; Yuki Yamashita; Ayumi Sugiura; Tomoo Yamazaki; Koichiro Kuwahara; Takeji Umemura
PLOS ONE, 16(4), Apr. 2021
Lead

心筋胎児型遺伝子発現調節経路 (特集 ナトリウム利尿ペプチドに関する話題)
桑原 宏一郎;クワハラ コウイチロウ
循環器内科 = Cardioangiology / 循環器内科編集委員会 編, 89(4), 375-378, Apr. 2021

A case of Dressler's syndrome successfully treated with colchicine and acetaminophen
Fumika Nomoto; Sho Suzuki; Naoto Hashizume; Yusuke Kanzaki; Takuya Maruyama; Ayako Kozuka; Tatsuya Saigusa; Soichiro Ebisawa; Ayako Okada; Hirohiko Motoki; Kumiko Yahikozawa; Koichiro Kuwahara
Journal of Cardiology Cases, 23(3), 131-135, Mar. 2021
Lead

A case of transient ventricular pre-excitation associated with takotsubo cardiomyopathy
Hideki Kobayashi; Hiroaki Tabata; Wataru Shoin; Takahiro Okano; Koji Yoshie; Ayako Okada; Morio Shoda; Koichiro Kuwahara
JOURNAL OF ELECTROCARDIOLOGY, 65, 73-75, Mar. 2021
Lead

Searching for the Frequency of Cardiac Transthyretin Amyloidosis among Elderly Heart Failure Patients Noninvasively Using 99mTc-labeled Pyrophosphate Scintigraphy
Miura, Takashi; Okina, Yoshiteru ; Mochidome, Tomoaki; Kobayashi, Takahiro; Kasai, Toshio; Ikeda, Uichi; Ezawa, Naoki; Sekijima, Yoshiki; Kuwahara, Koichiro
The Shinshu Medical Journal, 69(1), 37-44, 10 Feb. 2021

Prognostic value of reduction in left atrial size during a follow-up of heart failure: an observational study.
Masayuki Shiba; Takao Kato; Takeshi Morimoto; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Yuta Seko; Erika Yamamoto; Yusuke Yoshikawa; Takeshi Kitai; Yugo Yamashita; Moritake Iguchi; Kazuya Nagao; Yuichi Kawase; Takashi Morinaga; Mamoru Toyofuku; Yutaka Furukawa; Kenji Ando; Kazushige Kadota; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
BMJ open, 11(2), e044409, Feb. 2021
Lead

Successful catheter ablation of atrial tachycardia in cor triatriatum sinister: A figure-of-8 reentry in the left atrial membrane
Ayako Okada; Ken Kato; Morio Shoda; Hiroaki Tabata; Koji Yoshie; Koichiro Kuwahara
HeartRhythm Case Reports, 7(2), 109-111, Feb. 2021
Lead

Granulocyte colony stimulating factor-associated aortitis evaluated via multiple imagingmodalities including vascular echography: a case report
Mikiko Harada; Hirohiko Motoki; Takahiro Sakai; Koichiro Kuwahara
EUROPEAN HEART JOURNAL-CASE REPORTS, 5(2), Feb. 2021
Lead

Prognostic usefulness of residual SYNTAX score combined with clinical factors for patients with acute coronary syndrome who underwent percutaneous coronary intervention from the SHINANO Registry
Daisuke Kashiwagi; Soichiro Ebisawa; Hisanori Yui; Shusaku Maruyama; Ayumu Nagae; Takahiro Sakai; Tamon Kato; Tatsuya Saigusa; Ayako Okada; Hirohiko Motoki; Koichiro Kuwahara
HEART AND VESSELS, 36(2), 170-179, Feb. 2021
Lead

KCHF Study InvestigatorsSex differences in patients with acute decompensated heart failure in Japan: observation from the KCHF registry (vol 7, pg 2485, 2020)
Erika Yamamoto; Takao Kato; Hidenori Yaku; Takeshi Morimoto; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Yusuke Yoshikawa; Takeshi Kitai; Ryoji Taniguchi; Moritake Iguchi; Masashi Kato; Mamoru Takahashi; Toshikazu Jinnai; Tomoyuki Ikeda; Yoshihiro Himura; Kazuya Nagao; Takafumi Kawai; Akihiro Komasa; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Mitsunori Kawato; Yuta Seko; Mamoru Toyofuku; Yutaka Furukawa; Yoshihisa Nakagawa; Kenji Ando; Kazushige Kadota; Satoshi Shizuta; Koh Ono; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
ESC HEART FAILURE, 8(1), 784-784, Feb. 2021
Lead

Simultaneous infection of abandoned leads and newly implanted leadless cardiac pacemaker: Why did this occur?
Ayako Okada; Morio Shoda; Hiroaki Tabata; Hideki Kobayashi; Wataru Shoin; Takahiro Okano; Koji Yoshie; Ken Kato; Hirohiko Motoki; Koichiro Kuwahara
Journal of Cardiology Cases, 23(1), 35-37, Jan. 2021
Lead

Visualization of Spatially-Controlled Vasospasm by Sympathetic Nerve-Mediated ROCK Activation
Ayako Imanishi; Hiroshi Ichise; Chuyun Fan; Yasuaki Nakagawa; Koichiro Kuwahara; Kenta Sumiyama; Michiyuki Matsuda; Kenta Terai
AMERICAN JOURNAL OF PATHOLOGY, 191(1), 194-203, Jan. 2021
Lead

Impact of nutritional index on long-term outcomes of elderly patients with coronary artery disease: sub-analysis of the SHINANO 5 year registry
Shusaku Maruyama; Souichiro Ebisawa; Takashi Miura; Hisanori Yui; Daisuke Kashiwagi; Ayumu Nagae; Takahiro Sakai; Tamon Kato; Tatsuya Saigusa; Ayako Okada; Hirohiko Motoki; Koichiro Kuwahara
HEART AND VESSELS, 36(1), 7-13, Jan. 2021
Lead

"Alpha"-Looped Broken Pacemaker Lead Inside the Heart
Hiroaki Tabata; Ayako Okada; Hideki Kobayashi; Wataru Shoin; Takahiro Okano; Koji Yoshie; Hirohiko Motoki; Morio Shoda; Koichiro Kuwahara
CIRCULATION JOURNAL, 85(1), 77-77, Jan. 2021
Lead

Leadless cardiac pacemaker implantations after infected pacemaker system removals in octogenarians
Satoshi Higuchi; Ayako Okada; Morio Shoda; Daigo Yagishita; Satoshi Saito; Miwa Kanai; Shohei Kataoka; Kyoichiro Yazaki; Hiroaki Tabata; Hideki Kobayashi; Wataru Shoin; Takahiro Okano; Koji Yoshie; Koichiro Ejima; Koichiro Kuwahara; Nobuhisa Hagiwara
JOURNAL OF GERIATRIC CARDIOLOGY, 18(7), 505-513, 2021
Lead

Association of the Prognosis of Ankle-brachial Index Improvement One Year Following Endovascular Therapy in Patients with Peripheral Artery Disease: Data from the I-PAD NAGANO Registry
Keisuke Senda; Takashi Miura; Tamon Kato; Yusuke Kanzaki; Naoyuki Abe; Daisuke Yokota; Takashi Yanagisawa; Yoshiteru Okina; Tadamasa Wakabayashi; Yushi Oyama; Kenichi Karube; Tadashi Itagaki; Hidetsugu Yoda; Kyoko Shoin; Yasutaka Oguchi; Katsuyuki Aizawa; Chihiro Suzuki; Koichiro Kuwahara
INTERNAL MEDICINE, 60(13), 1999-2006, 2021
Lead

Influence of Worsening Heart Failure During Hospitalization on the Prognosis in Patients with Acute Decompensated Heart Failure
Yamamoto, Erika; Kato, Takao; Yaku, Hidenori; Morimoto, Takeshi; Inuzuka, Yasutaka; Tamaki, Yodo; Ozasa, Neiko; Sato, Yukihito; Kuwahara, Koichiro; Kimura, Takeshi;
Circulation, 144, 2021

Association of an increase in serum albumin levels with positive 1-year outcomes in acute decompensated heart failure: A cohort study
Takao Kato; Hidenori Yaku; Takeshi Morimoto; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Erika Yamamoto; Yusuke Yoshikawa; Takeshi Kitai; Ryoji Taniguchi; Moritake Iguchi; Masashi Kato; Mamoru Takahashi; Toshikazu Jinnai; Tomoyuki Ikeda; Kazuya Nagao; Takafumi Kawai; Akihiro Komasa; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Mitsunori Kawato; Yuta Seko; Masayuki Shiba; Mamoru Toyofuku; Yutaka Furukawa; Kenji Ando; Kazushige Kadota; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
PLOS ONE, 15(12), Dec. 2020
Lead

Impact of changes in body mass index after percutaneous coronary intervention on long-term outcomes in patients with coronary artery disease
Hisanori Yui; Soichiro Ebisawa; Takashi Miura; Chie Nakamura; Shusaku Maruyama; Daisuke Kashiwagi; Ayumu Nagae; Takahiro Sakai; Tamon Kato; Tatsuya Saigusa; Ayako Okada; Hirohiko Motoki; Koichiro Kuwahara
HEART AND VESSELS, 35(12), 1657-1663, Dec. 2020
Lead

Current Status of Heart Failure Drug Ttreatment
KUWAHARA Koichiro
The Shinshu Medical Journal, 68(6), 349-355, Dec. 2020

Cardio-renal and cardio-hepatic interactions predict cardiovascular events in elderly patients with heart failure
Takahiro Okano; Hirohiko Motoki; Masatoshi Minamisawa; Kazuhiro Kimura; Masafumi Kanai; Koji Yoshie; Satoko Higuchi; Tatsuya Saigusa; Soichiro Ebisawa; Ayako Okada; Morio Shoda; Koichiro Kuwahara
PLOS ONE, 15(10), Oct. 2020
Lead

Association between body mass index and prognosis of patients hospitalized with heart failure
Yuta Seko; Takao Kato; Takeshi Morimoto; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Masayuki Shiba; Erika Yamamoto; Yusuke Yoshikawa; Yugo Yamashita; Takeshi Kitai; Ryoji Taniguchi; Moritake Iguchi; Kazuya Nagao; Takafumi Kawai; Akihiro Komasa; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Mamoru Toyofuku; Yutaka Furukawa; Kenji Ando; Kazushige Kadota; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
SCIENTIFIC REPORTS, 10(1), Oct. 2020
Lead

Prognostic impact of mineralocorticoid receptor antagonist in patients with heart failure with preserved ejection fraction
Sho Suzuki; Hirohiko Motoki; Yusuke Kanzaki; Takuya Maruyama; Naoto Hashizume; Ayako Kozuka; Kumiko Yahikozawa; Koichiro Kuwahara
ESC HEART FAILURE, 7(5), 2752-2761, Oct. 2020
Lead

Sex differences in patients with acute decompensated heart failure in Japan: observation from the KCHF registry
Erika Yamamoto; Takao Kato; Hidenori Yaku; Takeshi Morimoto; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Takeshi Kitai; Ryoji Taniguchi; Moritake Iguchi; Masashi Kato; Mamoru Takahashi; Toshikazu Jinnai; Tomoyuki Ikeda; Yoshihiro Himura; Kazuya Nagao; Takafumi Kawai; Akihiro Komasa; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Mitsunori Kawato; Yuta Seko; Mamoru Toyofuku; Yutaka Furukawa; Yoshihisa Nakagawa; Kenji Ando; Kazushige Kadota; Satoshi Shizuta; Koh Ono; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
ESC HEART FAILURE, 7(5), 2485-2493, Oct. 2020
Lead

Impact of left ventricular ejection fraction on the effect of renin-angiotensin system blockers after an episode of acute heart failure: From the KCHF Registry
Yusuke Yoshikawa; Yodo Tamaki; Takeshi Morimoto; Hidenori Yaku; Erika Yamamoto; Yasutaka Inuzuka; Neiko Ozasa; Takeshi Kitai; Kazuya Nagao; Yukihito Sato; Hirokazu Kondo; Toshihiro Tamura; Yoshihisa Nakagawa; Koichiro Kuwahara; Takao Kato; Takeshi Kimura
PLOS ONE, 15(9), e0239100-e0239100, Sep. 2020
Lead

Rationale and Design of Therapeutic Angiogenesis by Cell Transplantation Using Adipose-Derived Regenerative Cells in Patients With Critical Limb Ischemia - TACT-ADRC Multicenter Trial.
Yuuki Shimizu; Kazuhisa Kondo; Yoshihiro Fukumoto; Masayuki Takamura; Teruo Inoue; Tokuichiro Nagata; Yoshihiro J Akashi; Yoshihiro Yamada; Koichiro Kuwahara; Yoshio Kobayashi; Rei Shibata; Toyoaki Murohara
Circulation reports, 2(9), 531-535, Aug. 2020
Lead

Prognostic significance of resting heart rate in atrial fibrillation patients with heart failure with reduced ejection fraction
Sho Suzuki; Hirohiko Motoki; Yusuke Kanzaki; Takuya Maruyama; Naoto Hashizume; Ayako Kozuka; Kumiko Yahikozawa; Koichiro Kuwahara
HEART AND VESSELS, 35(8), 1109-1115, Aug. 2020
Lead

Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo.
Hajime Ichimura; Shin Kadota; Toshihide Kashihara; Mitsuhiko Yamada; Kuniaki Ito; Hideki Kobayashi; Yuki Tanaka; Naoko Shiba; Shinichiro Chuma; Shugo Tohyama; Tatsuichiro Seto; Kenji Okada; Koichiro Kuwahara; Yuji Shiba
Scientific reports, 10(1), 11883-11883, Jul. 2020
Lead

超高齢社会を迎えた心不全診療のあり方 高齢の急性心不全患者における機能低下、繰り返す入退院、および治療と長期予後との関連(Association of Functional Decline, Repeated Hospitalization, and Treatment with Long-term Prognosis in Older Adults with Acute Heart Failure)
夜久 英憲; 加藤 貴雄; 森本 剛; 犬塚 康孝; 田巻 庸道; 小笹 寧子; 山本 絵里香; 佐藤 幸人; 桑原 宏一郎; 木村 剛
日本循環器学会学術集会抄録集, 84回, シンポジウム5-3, Jul. 2020
Lead

Impact of Ambulation Status in Patients with End-stage Renal Disease on Hemodialysis due to Diabetic Nephropathy : The PREDICT Study
Kato T, Miyashita Y, Sone H, Mizukami T, Kanno Y, Oguchi T, Yokota D, Shiotsuki N, Mizukami E, Terashima M, Aruga M, Yui H, Maruyama S, Kobayashi H, Kashiwagi D, Nagae A, Sakai T, Saigusa T, Ebisawa S, Okada A, Motoki H, Kuwahara K
The Shinshu Medical Journal, 68(3), 131-138, 10 Jun. 2020

Prognostic Impact of Cardio-renal-anemia Syndrome in Patients at Risk for Heart Failure from the IMPACT-ABI study
Shoin W, Ebisawa S, Saigusa T, Sakai T, Oguchi Y, Okada A, Motoki H, Kuwahara K
The Shinshu Medical Journal, 68(3), 139-147, 10 Jun. 2020

Rationale and design of the EMPYREAN study.
Hirohiko Motoki; Izuru Masuda; Shinji Yasuno; Koji Oba; Wataru Shoin; Satoru Usami; Yoshihiko Saito; Masako Waki; Mitsuhisa Komatsu; Kenji Ueshima; Yasuaki Nakagawa; Cheol Son; Shin Yonemitsu; Shinya Hiramitsu; Manako Konda; Katsuya Onishi; Koichiro Kuwahara
ESC heart failure, 7(5), 3134-3141, Jun. 2020, Refereed, Not invited
Lead

Sodium-Glucose Cotransporter-2 inhibitors are potential therapeutic agents for treatment of non-diabetic heart failure patients.
Yasuaki Nakagawa; Koichiro Kuwahara
Journal of cardiology, 76(2), 123-131, Apr. 2020, Refereed, Not invited
Lead

Successful hot balloon ablation for focal atrial tachycardia derived from the left superior pulmonary vein antrum
Hiroaki Tabata; Ayako Okada; Hideki Kobayashi; Wataru Shoin; Takahiro Okano; Koji Yoshie; Hirohiko Motoki; Morio Shoda; Koichiro Kuwahara
JOURNAL OF ARRHYTHMIA, 36(2), 368-370, Apr. 2020
Lead

MRTF-A promotes angiotensin II-induced inflammatory response and aortic dissection in mice
Sohei Ito; Yohei Hashimoto; Ryohei Majima; Eichi Nakao; Hiroki Aoki; Michihide Nishihara; Satoko Ohno-Urabe; Aya Furusho; Saki Hirakata; Norifumi Nishida; Makiko Hayashi; Koichiro Kuwahara; Yoshihiro Fukumoto
PLOS ONE, 15(3), Mar. 2020
Lead

Establishment of optimal exercise therapy using near-infrared spectroscopy monitoring of tissue muscle oxygenation after therapeutic angiogenesis for patients with critical limb ischemia: A multicenter, randomized, controlled trial
Keisuke Shoji; Kenji Yanishi; Hirokazu Shiraishi; Shiho Yamabata; Arito Yukawa; Satoshi Teramukai; Kojiro Imai; Toshiko Ito-Ihara; Masami Tao; Yukihito Higashi; Tomoaki Ishigami; Yoshihiro Fukumoto; Koichiro Kuwahara; Satoaki Matoba
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS, 17, Mar. 2020
Lead

A Predictive Model for 6-Month Mortality in Elderly Patients with Heart Failure
Sho Suzuki; Hirohiko Motoki; Yusuke Kanzaki; Takuya Maruyama; Naoto Hashizume; Ayako Kozuka; Kumiko Yahikozawa; Koichiro Kuwahara
INTERNATIONAL HEART JOURNAL, 61(2), 325-331, Mar. 2020
Lead

TRPCチャネル阻害薬の肺高血圧の新規治療薬としての可能性
森内 健史; 木下 秀之; 中川 靖章; 西田 基宏; 森 泰生; 中村 一文; 稲住 英明; 中尾 一和; 桑原 宏一郎; 木村 剛
日本内分泌学会雑誌, 95(4), 1599-1599, Feb. 2020
Lead

Defibrillation failure with short ICD charge time: Internal short circuit of a Durata lead
Ayako Okada; Wataru Shoin; Morio Shoda; Hiroaki Tabata; Hideki Kobayashi; Takahiro Okano; Koji Yoshie; Ken Kato; Koichiro Kuwahara
Journal of Cardiology Cases, 21(2), 59-62, Feb. 2020
Lead

Association with Controlling Nutritional Status (CONUT) Score and In-hospital Mortality and Infection in Acute Heart Failure
Takao Kato; Hidenori Yaku; Takeshi Morimoto; Yasutaka Inuzuka; Yodo Tamaki; Erika Yamamoto; Yusuke Yoshikawa; Takeshi Kitai; Ryoji Taniguchi; Moritake Iguchi; Masashi Kato; Mamoru Takahashi; Toshikazu Jinnai; Tomoyuki Ikeda; Kazuya Nagao; Takafumi Kawai; Akihiro Komasa; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Kanae Su; Mitsunori Kawato; Yuta Seko; Moriaki Inoko; Mamoru Toyofuku; Yutaka Furukawa; Yoshihisa Nakagawa; Kenji Ando; Kazushige Kadota; Satoshi Shizuta; Koh Ono; Yukihito Sato; Koichiro Kuwahara; Neiko Ozasa; Takeshi Kimura
SCIENTIFIC REPORTS, 10(1), Feb. 2020
Lead

Risk factors and clinical outcomes of functional decline during hospitalisation in very old patients with acute decompensated heart failure: an observational study
Hidenori Yaku; Takao Kato; Takeshi Morimoto; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Erika Yamamoto; Yusuke Yoshikawa; Takeshi Kitai; Masashi Kato; Tomoyuki Ikeda; Yutaka Furukawa; Yoshihisa Nakagawa; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura
BMJ OPEN, 10(2), Feb. 2020
Lead

A Statement on the Appropriate Administration of Tafamidis in Patients With Transthyretin Cardiac Amyloidosis
Endo, Jin; Sano, Motoaki; Izumiya, Yasuhiro; Tsujita, Kenichi; Nakamura, Kazufumi; Tahara, Nobuhiro; Kuwahara, Koichiro; Inomata, Takayuki; Ueda, Mitsuharu; Sekijima, Yoshiki; Ando, Yukio; Tsutsui, Hiroyuki; Isobe, Mitsuaki; Fukuda, Keiichi;
CIRCULATION JOURNAL, 84(1), 15-17, Jan. 2020

C-reactive protein at discharge and 1-year mortality in hospitalised patients with acute decompensated heart failure: an observational study
Yuji Nishimoto; Takao Kato; Takeshi Morimoto; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Erika Yamamoto; Yusuke Yoshikawa; Takeshi Kitai; Ryoji Taniguchi; Moritake Iguchi; Masashi Kato; Mamoru Takahashi; Toshikazu Jinnai; Tomoyuki Ikeda; Kazuya Nagao; Takafumi Kawai; Akihiro Komasa; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Kanae Su; Mitsunori Kawato; Yuta Seko; Moriaki Inoko; Mamoru Toyofuku; Yutaka Furukawa; Yoshihisa Nakagawa; Kenji Ando; Kazushige Kadota; Satoshi Shizuta; Koh Ono; Koichiro Kuwahara; Neiko Ozasa; Yukihito Sato; Takeshi Kimura
BMJ OPEN, 10(12), 2020
Lead

Increased Ga(o)Expression Regulated by NRSF Plays a Key Role in the Development of Heart Failure Through the Impairment of Ca2+ Homeostasis
Inazumi, Hideaki; Nakagawa, Yasuaki; Moriuchi, Kenji; Kuwahara, Koichiro;
Circulation Research, 127, 2020

A Statement on the Appropriate Administration of Tafamidis in Patients With Transthyretin Cardiac Amyloidosis.
Jin Endo; Motoaki Sano; Yasuhiro Izumiya; Kenichi Tsujita; Kazufumi Nakamura; Nobuhiro Tahara; Koichiro Kuwahara; Takayuki Inomata; Mitsuharu Ueda; Yoshiki Sekijima; Yukio Ando; Hiroyuki Tsutsui; Mitsuaki Isobe; Keiichi Fukuda
Circulation journal : official journal of the Japanese Circulation Society, 84(1), 15-17, Dec. 2019, Refereed, Not invited
Lead

Association of Previous Hospitalization for Heart Failure With Increased Mortality in Patients Hospitalized for Acute Decompensated Heart Failure
Kanae Su; Takao Kato; Mamoru Toyofuku; Takeshi Morimoto; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Erika Yamamoto; Yusuke Yoshikawa; Yasuyo Motohashi; Hiroki Watanabe; Takeshi Kitai; Ryoji Taniguchi; Moritake Iguchi; Masashi Kato; Kazuya Nagao; Takafumi Kawai; Akihiro Komasa; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Toshikazu Jinnai; Mitsunori Kawato; Yukihito Sato; Koichiro Kuwahara; Takashi Tamura; Takeshi Kimura
Circulation Reports, 1(11), 517-524, Nov. 2019, Refereed, Not invited
Lead

Biopsy detection and clinical management of acute lymphocytic myocarditis in pregnancy
Daisuke Sunohara; Hirohiko Motoki; Tatsuya Saigusa; Soichiro Ebisawa; Ayako Okada; Hirofumi Ando; Midori Sato; Koichiro Kuwahara
Journal of Cardiology Cases, 20(5), 164-167, Nov. 2019
Lead

Impact of inpatient cardiac rehabilitation on Barthel Index score and prognosis in patients with acute decompensated heart failure
Hirohiko Motoki; Musashi Nishimura; Masafumi Kanai; Kazuhiro Kimura; Masatoshi Minamisawa; Shuhei Yamamoto; Tatsuya Saigusa; Soichiro Ebisawa; Ayako Okada; Koichiro Kuwahara
INTERNATIONAL JOURNAL OF CARDIOLOGY, 293, 125-130, Oct. 2019
Lead

Prognostic significance of high-sensitivity cardiac troponin in patients with heart failure with preserved ejection fraction
Sho Suzuki; Hirohiko Motoki; Masatoshi Minamisawa; Yukari Okuma; Wataru Shoin; Takahiro Okano; Kazuhiro Kimura; Soichiro Ebisawa; Ayako Okada; Koichiro Kuwahara
HEART AND VESSELS, 34(10), 1650-1656, Oct. 2019
Lead

Association between reactive hyperemia peripheral arterial tonometry index and atrial fibrillation recurrence after catheter ablation
Hideki Kobayashi; Ayako Okada; Hiroaki Tabata; Wataru Shoin; Takahiro Okano; Koji Yoshie; Yasutaka Oguchi; Ken Kato; Morio Shoda; Koichiro Kuwahara
IJC HEART & VASCULATURE, 24, Sep. 2019
Lead

Epicardial Stone - Unfamiliar Calcified Mass at the Site of Left Ventricular Old Myocardial Infarction -
Hiroaki Tabata; Hirohiko Motoki; Takahiro Sakai; Ayako Okada; Koichiro Kuwahara
CIRCULATION JOURNAL, 83(9), 1969-1969, Sep. 2019
Lead

MRTF-A regulates proliferation and survival properties of pro-atherogenic macrophages.
Jianbo An; Taeko K Naruse; Kunihiko Hinohara; Yurie Soejima; Motoji Sawabe; Yasuaki Nakagawa; Koichiro Kuwahara; Akinori Kimura
Journal of molecular and cellular cardiology, 133, 26-35, Aug. 2019, Refereed, Not invited
Lead

Overexpression of the HCN2 channel increases the arrhythmogenicity induced by hypokalemia.
Kensuke Oshita; Yuko Kozasa; Yasuaki Nakagawa; Yoshihiro Kuwabara; Koichiro Kuwahara; Taku Nakagawa; Noriyuki Nakashima; Teruyuki Hiraki; Makoto Takano
The journal of physiological sciences : JPS, 69(4), 653-660, Jul. 2019, Refereed, Not invited
Lead

Ankle-Brachial Index as a Prognostic Indicator in Patients with Atrial Fibrillation -A Subanalysis of the IMPACT-ABI Study
Oguchi Y, Saigusa T, Ebisawa S, Okada A, Motoki H, Kuwahara K
The Shinshu Medical Journal, 67(3), 197-204, 10 Jun. 2019

Role of echocardiography in assessing cardiac amyloidoses: a systematic review
Jun Koyama; Masatoshi Minamisawa; Yoshiki Sekijima; Koichiro Kuwahara; Tsutomu Katsuyama; Kazutoshi Maruyama
JOURNAL OF ECHOCARDIOGRAPHY, 17(2), 64-75, Jun. 2019
Lead

Association of Mineralocorticoid Receptor Antagonist Use With All-Cause Mortality and Hospital Readmission in Older Adults With Acute Decompensated Heart Failure
Hidenori Yaku; Takao Kato; Takeshi Morimoto; Yasutaka Inuzuka; Yodo Tamaki; Neiko Ozasa; Erika Yamamoto; Yusuke Yoshikawa; Takeshi Kitai; Ryoji Taniguchi; Moritake Iguchi; Masashi Kato; Mamoru Takahashi; Toshikazu Jinnai; Tomoyuki Ikeda; Kazuya Nagao; Takafumi Kawai; Akihiro Komasa; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Mamoru Toyofuku; Yuta Seko; Yutaka Furukawa; Yoshihisa Nakagawa; Kenji Ando; Kazushige Kadota; Satoshi Shizuta; Koh Ono; Yukihito Sato; Koichiro Kuwahara; Takeshi Kimura; Tetsuo Shioi; Yugo Yamashita; Masaharu Akao; Shinji Miki; Tsuneaki Kawashima; Takafumi Yagi; Takashi Konishi; Shigeru Ikeguchi; Yoshihiro Himura; Tsukasa Inada; Kenichi Sasaki; Moriaki Inoko; Tomoki Sasa; Mitsuo Matsuda; Katsuhisa Ishii; Yoshiki Takatsu; Ryousuke Murai; Mitsunori Kawato; Yasuyo Motohashi; Kanae Su; Takashi Tamura; Reiko Hozo; Hiroki Sakamoto; Keiichiro Iwasaki; Yohei Kobayashi; Kenji Ando
JAMA NETWORK OPEN, 2(6), Jun. 2019
Lead

Wire perforation causing cardiopulmonary arrest during radiofrequency hot balloon ablation for pulmonary vein isolation
Takahiro Okano; Ayako Okada; Hiroaki Tabata; Hideki Kobayashi; Wataru Shoin; Koji Yoshie; Yasutaka Oguchi; Morio Shoda; Koichiro Kuwahara
Journal of Cardiology Cases, 19(5), 169-172, May 2019
Lead

Utility of copeptin for predicting long-term clinical outcomes in patients with heart failure
Yusuke Yoshikawa; Hiroki Shiomi; Koichiro Kuwahara; Naoya Sowa; Hidenori Yaku; Yugo Yamashita; Junichi Tazaki; Masao Imai; Takao Kato; Naritatsu Saito; Satoshi Shizuta; Koh Ono; Takeshi Kimura
Journal of Cardiology, 73(5), 379-385, May 2019
Lead

Successful inferior vena cava filter removal using pacemaker lead extraction methods
Tadashi Itagaki; Ayako Okada; Hiroaki Tabata; Wataru Shoin; Hideki Kobayashi; Takahiro Okano; Yasutaka Oguchi; Tomoaki Mochidome; Tatsuya Saigusa; Soichiro Ebisawa; Hirohiko Motoki; Morio Shoda; Koichiro Kuwahara
Journal of Cardiology Cases, 19(4), 129-132, Apr. 2019
Lead

抑制性G蛋白サブユニットGαoの発現亢進はCa2+handlingの異常を介して心不全進展にかかわる
稲住 英明; 桑原 宏一郎; 桑原 佳宏; 中川 靖章; 木下 秀之; 錦見 俊雄; 呉林 なごみ; 山田 充彦; 柏原 俊英; 中尾 一和; 木村 剛
日本臨床分子医学会学術総会プログラム・抄録集, 56回, 47-47, Apr. 2019
Lead

Comparison of leg loader and treadmill exercise for evaluating patients with peripheral artery disease
Yasushi Ueki; Takashi Miura; Tomoaki Mochidome; Keisuke Senda; Soichiro Ebisawa; Tatsuya Saigusa; Hirohiko Motoki; Ayako Okada; Jun Koyama; Koichiro Kuwahara
HEART AND VESSELS, 34(4), 590-596, Apr. 2019
Lead

Single-center experience with percutaneous lead extraction of cardiac implantable electric devices (vol 71, pg 192, 2018)
Ayako Okada; Morio Shoda; Hiroaki Tabata; Wataru Shoin; Hideki Kobayashi; Takahiro Okano; Koji Yoshie; Yasutaka Oguchi; Takahiro Takeuchi; Ken Kato; Koichiro Kuwahara
JOURNAL OF CARDIOLOGY, 73(3-4), 262-262, Mar. 2019
Lead

Impact of Therapeutic Angiogenesis Using Autologous Bone Marrow-Derived Mononuclear Cells Implantation in Critical Limb Ischemia With Scleroderma - Subanalysis of the Long-Term Clinical Outcomes Survey -
Shoji, Keisuke; Yanishi, Kenji; Yoshimi, Ryusuke; Hamada, Naoki; Kondo, Kazuhisa; Fujimoto, Kazuteru; Nakajima, Hideaki; Kuwahara, Koichiro; Higashi, Yukihito; Fukumoto, Yoshihiro; Murohara, Toyoaki; Matoba, Satoaki; Hayashida, Ryo; Shibata, Rei; Murotani, Kenta; Ando, Masahiko; Mizuno, Masaaki; Fujiwara, Tadami; Fujimoto, Kazuteru; Kato, Tamon; Kajikawa, Masato; Ootsuka, Masanori; Sasaki, Kenichiro; Saito, Yoshihiko; Fukumoto, Shinya
CIRCULATION JOURNAL, 83(3), 662-671, Mar. 2019, Refereed, Not invited
Lead

Establishment of a Healthcare System for Patients With Adult Congenital Heart Disease in Collaboration With Children's Hospital - The Nagano Model -
Hirohiko Motoki; Satoshi Yasukochi; Kiyohiro Takigiku; Kohta Takei; Toru Okamura; Kazuhiro Kimura; Masatoshi Minamisawa; Ayako Okada; Tatsuya Saigusa; Soichiro Ebisawa; Tatsuichiro Seto; Morio Shoda; Kenji Okada; Koichiro Kuwahara
CIRCULATION JOURNAL, 83(2), 424-431, Feb. 2019
Lead

A case of thrombolytic therapy with recombinant tissue plasminogen activator for mechanical valve thrombosis at 9 weeks of pregnancy in a Japanese woman
Toshinori Komatsu; Hirohiko Motoki; Kazuhiro Kimura; Tatsuya Saigusa; Soichiro Ebisawa; Yusuke Yokokawa; Hirofumi Ando; Takashi Ichino; Koichiro Kuwahara
Journal of Cardiology Cases, 19(1), 15-18, Jan. 2019
Lead

Atrial and brain natriuretic peptides: Hormones secreted from the heart
Nakagawa Y, Nishikimi T, Kuwahara K
PEPTIDES, 111, 18-25, 2019

A case of thrombolytic therapy with recombinant tissue plasminogen activator for mechanical valve thrombosis at 9 weeks of pregnancy in a Japanese woman
Komatsu T, Motoki H, Kimura K, Saigusa T, Ebisawa S, Yokokawa Y, Ando H, Ichino T, Kuwahara K.
J Cardiol Cases, 19(1), 15-18, 2019

Wire perforation causing cardiopulmonary arrest during radiofrequency hot balloon ablation for pulmonary vein isolation
Okano T, Okada A, Tabata H, Kobayashi H, Shoin W, Yoshie K, Oguchi Y, Shoda M, Kuwahara K
J Cardiol Cases, 19(5), 169-172, 2019

Successful inferior vena cava filter removal using pacemaker lead extraction methods
Itagaki T, Okada A, Tabata H, Shoin W, Kobayashi H, Okano T, Oguchi Y, Mochidome T, Saigusa T, Ebisawa S, Motoki H, Shoda M, Kuwahara K
J Cardiol Cases, 19(4), 129-132, 2019

Biopsy detection and clinical management of acute lymphocytic myocarditis in pregnancy
Sunohara D, Motoki H, Saigusa T, Ebisawa S, Okada A, Ando H, Sato M, Kuwahara K
J Cardiol Cases, 20(5), 164-167, 2019

心不全モデルマウスにおけるG蛋白サブユニットGαoの発現亢進はCa2+handlingの異常をきたし心収縮能低下に関与する
稲住 英明; 桑原 宏一郎; 桑原 佳宏; 中川 靖章; 木下 秀之; 錦見 俊雄; 呉林 なごみ; 山田 充彦; 中尾 一和; 木村 剛
日本内分泌学会雑誌, 94(4), 1545-1545, Dec. 2018
Lead

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence
Akiyuki Nishimura; Tsukasa Shimauchi; Tomohiro Tanaka; Kakeru Shimoda; Takashi Toyama; Naoyuki Kitajima; Tatsuya Ishikawa; Naoya Shindo; Takuro Numaga-Tomita; Satoshi Yasuda; Yoji Sato; Koichiro Kuwahara; Yoshito Kumagai; Takaaki Akaike; Tomomi Ide; Akio Ojida; Yasuo Mori; Motohiro Nishida
SCIENCE SIGNALING, 11(556), eaat5185, Nov. 2018
Lead

Demographics, Management, and In-Hospital Outcome of Hospitalized Acute Heart Failure Syndrome Patients in Contemporary Real Clinical Practice in Japan ― Observations From the Prospective, Multicenter Kyoto Congestive Heart Failure (KCHF) Registry ―
Hidenori Yaku; Neiko Ozasa; Takeshi Morimoto; Yasutaka Inuzuka; Yodo Tamaki; Erika Yamamoto; Yusuke Yoshikawa; Takeshi Kitai; Ryoji Taniguchi; Moritake Iguchi; Masashi Kato; Mamoru Takahashi; Toshikazu Jinnai; Tomoyuki Ikeda; Kazuya Nagao; Takafumi Kawai; Akihiro Komasa; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Kanae Su; Mitsunori Kawato; Kenichi Sasaki; Mamoru Toyofuku; Yutaka Furukawa; Yoshihisa Nakagawa; Kenji Ando; Kazushige Kadota; Satoshi Shizuta; Koh Ono; Yukihito Sato; Koichiro Kuwahara; Takao Kato; Takeshi Kimura
Circulation Journal, 82(11), 2811-2819, Oct. 2018
Lead

T-wave alternans in a case with systemic lupus erythematosus-related myocarditis.
Mikiko Harada; Hirohiko Motoki; Yuichiro Kashima; Chie Nakamura; Naoto Hashizume; Dai Kishida; Hiroshi Imamura; Koichiro Kuwahara
Journal of cardiology cases, 18(4), 119-122, Oct. 2018
Lead

Cutting Edge of Brain Natriuretic Peptide (BNP) Research - The Diversity of BNP Immunoreactivity and Its Clinical Relevance.
Koichiro Kuwahara; Yasuaki Nakagawa; Toshio Nishikimi
Circulation journal : official journal of the Japanese Circulation Society, 82(10), 2455-2461, Sep. 2018, Refereed, Not invited
Lead

Predictive Value of Underweight Status for Patients With Peripheral Artery Disease With Claudication
Keisuke Senda; Takashi Miura; Masatoshi Minamisawa; Yasushi Ueki; Tomoaki Mochidome; Hidetomo Nomi; Wataru Shoin; Satoko Higuchi; Yasutaka Oguchi; Hitoshi Nishimura; Tatsuya Saigusa; Soichiro Ebisawa; Hirohiko Motoki; Atsushi Izawa; Jun Koyama; Uichi Ikeda; Koichiro Kuwahara
ANGIOLOGY, 69(6), 513-522, Jul. 2018
Lead

Geriatric Nutritional Risk Index Predicts Cardiovascular Events in Patients at Risk for Heart Failure
Masatoshi Minamisawa; Takashi Miura; Hirohiko Motoki; Yasushi Ueki; Hitoshi Nishimura; Kunihiko Shimizu; Wataru Shoin; Mikiko Harada; Tomoaki Mochidome; Keisuke Senda; Koji Yoshie; Yasutaka Oguchi; Naoto Hashizume; Naoyuki Abe; Tatsuya Saigusa; Soichiro Ebisawa; Atsushi Izawa; Jun Koyama; Uichi Ikeda; Koichiro Kuwahara
CIRCULATION JOURNAL, 82(6), 1614-+, Jun. 2018
Lead

Duration of myocardial early systolic lengthening for diagnosis of coronary artery disease
Masatoshi Minamisawa; Jun Koyama; Ayako Kozuka; Takashi Miura; Tatsuya Saigusa; Soichiro Ebisawa; Hirohiko Motoki; Ayako Okada; Uichi Ikeda; Koichiro Kuwahara
OPEN HEART, 5(2), e000896, Jun. 2018
Lead

Atrial and brain natriuretic peptides: Hormones secreted from the heart.
Nakagawa Y; Nishikimi T; Kuwahara K
Peptides, 111, 18-25, May 2018, Refereed, Not invited
Lead

G蛋白サブユニットGαoのCa2+handling恒常性および心収縮能維持における意義の解明
稲住 英明; 桑原 宏一郎; 桑原 佳宏; 中川 靖章; 木下 秀之; 錦見 俊雄; 呉林 なごみ; 山田 充彦; 柏原 俊英; 中尾 一和; 木村 剛
日本臨床分子医学会学術総会プログラム・抄録集, 55回, 51-51, Apr. 2018
Lead

proBNP測定は心疾患の新たな評価法である可能性(Possibility of proBNP Measurement as a New Method for Evaluating the Heart Disease)
中川 靖章; 桑原 宏一郎; 錦見 俊雄; 木下 秀之; 稲住 英明; 森内 健史; 柳沢 洋; 南野 直人; 中尾 一和; 木村 剛
日本循環器学会学術集会抄録集, 82回, PL8-4, Mar. 2018
Lead

Macro-pro-B-type natriuretic peptide (proBNP) and hidden macro-N-terminal proBNP: Case report.
Nakagawa Y; Nishikimi T; Sakai H; Ohno S; Kinoshita H; Inazumi H; Moriuchi K; Kuwahara K; Horie M; Kimura T
Clinical biochemistry, 52, 148-152, Feb. 2018, Refereed, Not invited
Lead

Single-center experience with percutaneous lead extraction of cardiac implantable electric devices
Ayako Okada; Morio Shoda; Hiroaki Tabata; Wataru Shoin; Hideki Kobayashi; Takahiro Okano; Koji Yoshie; Yasutaka Oguchi; Takahiro Takeuchi; Ken Kato; Koichiro Kuwahara
JOURNAL OF CARDIOLOGY, 71(1-2), 192-196, Jan. 2018
Lead

Drug-eluting versus bare-metal stent implantation with or without cilostazol in the treatment of the superficial femoral artery: The debate in SFA study
Takashi Miura; Yusuke Miyashita; Yoshimitsu Soga; Koji Hozawa; Tatsuki Doijiri; Uichi Ikeda; Koichiro Kuwahara; DEBATE in SFA Investigators
Circulation: Cardiovascular Interventions, 11(8), 2018
Lead

Rats deficient C-type natriuretic peptide suffer from impaired skeletal growth without early death.
Toshihito Fujii; Keisho Hirota; Akihiro Yasoda; Akiko Takizawa; Naomi Morozumi; Ryuichi Nakamura; Takafumi Yotsumoto; Eri Kondo; Yui Yamashita; Yoriko Sakane; Yugo Kanai; Yohei Ueda; Ichiro Yamauchi; Shigeki Yamanaka; Kazumasa Nakao; Koichiro Kuwahara; Toshimasa Jindo; Mayumi Furuya; Tomoji Mashimo; Nobuya Inagaki; Tadao Serikawa; Kazuwa Nakao
PloS one, 13(3), e0194812, 2018, Refereed, Not invited
Lead

Cross-sectional study of the association between day-to-day home blood pressure variability and visceral fat area measured using the dual impedance method
Kuwabara J; Kuwahara K; Kuwabara Y; Yasuno S; Nakagawa Y; Ueshima K; Kimura T
PLoS One, 13(11), e0206945, 2018, Refereed, Not invited
Lead

Drug-Eluting Versus Bare-Metal Stent Implantation with or without Cilostazol in the Treatment of the Superficial Femoral Artery
Miura T, Miyashita Y, Soga Y, Hozawa K, Doijiri T, Ikeda U, Kuwahara K on behalf of the DEBATE in SFA investigators
Circ Cardiovasc Interv, 11(8), e006564, 2018

心不全バイオマーカーとしてのBNPの臨床的意義
桑原 宏一郎;
診断と治療 = Diagnosis and treatment, 105(12), 1603-1607, Dec. 2017

Prognostic Value of Ankle-Brachial Index in Patients Undergoing Percutaneous Coronary Intervention: In-Hospital and 1-Year Outcomes From the SHINANO Registry
Naoto Hashizume; Takashi Miura; Yusuke Miyashita; Hirohiko Motoki; Soichiro Ebisawa; Atsushi Izawa; Jun Koyama; Uichi Ikeda; Koichiro Kuwahara
ANGIOLOGY, 68(10), 884-892, Nov. 2017
Lead

Validation of a Prognostic Risk Score for Major Bleeding Events in Patients Undergoing Percutaneous Coronary Intervention: From the SHINANO Registry
Keisuke Senda; Takashi Miura; Tomoaki Mochidome; Takahiro Sakai; Masatoshi Minamisawa; Tamon Kato; Tatsuya Saigusa; Soichiro Ebisawa; Hirohiko Motoki; Koichiro Kuwahara
CIRCULATION, 136, Nov. 2017
Lead

Cardiac hyaluronan may be associated with the persistence of atrial fibrillation
Ayako Okada; Yuichiro Kashima; Takeshi Tomita; Takahiro Takeuchi; Yasutaka Oguchi; Koji Yoshie; Wataru Shoin; Morio Shoda; Kenichi Nitta; Koichiro Kuwahara; Hiroshi Imamura
HEART AND VESSELS, 32(9), 1144-1150, Sep. 2017
Lead

Efficacy and Safety of an Orally Administered Selective Prostacyclin Receptor Agonist, Selexipag, in Japanese Patients With Pulmonary Arterial Hypertension
Tanabe, Nobuhiro; Ikeda, Satoshi; Tahara, Nobuhiro; Fukuda, Keiichi; Hatano, Masaru; Ito, Hiroshi; Nakayama, Tomotaka; Anzai, Toshihisa; Hashimoto, Akiyoshi; Inoue, Teruo; Kajinami, Kouji; Kihara, Yasuki; Kinoshita, Hideyuki; Kuwahara, Koichiro; Murohara, Toyoaki; Okazaki, Osamu; Sakai, Satoshi; Satoh, Toru; Takeda, Yutaka; Takeishi, Yasuchika; Taniguchi, Mitsugu; Watanabe, Hiroshi; Yamamoto, Takeshi; Yamauchi-Takihara, Keiko; Yoshioka, Koichiro; Sasayama, Shigetake
Circulation Journal, 81(9), 1360-1367, Sep. 2017, Refereed, Not invited
Lead

Kyoto Congestive Heart Failure (KCHF) study: rationale and design
Erika Yamamoto; Takao Kato; Neiko Ozasa; Hidenori Yaku; Yasutaka Inuzuka; Yodo Tamaki; Takeshi Kitai; Takeshi Morimoto; Ryoji Taniguchi; Moritake Iguchi; Masashi Kato; Mamoru Takahashi; Toshikazu Jinnai; Tomoyuki Ikeda; Kazuya Nagao; Takafumi Kawai; Akihiro Komasa; Ryusuke Nishikawa; Yuichi Kawase; Takashi Morinaga; Tsuneaki Kawashima; Yasuyo Motohashi; Mitsunori Kawato; Mamoru Toyofuku; Yukihito Sato; Koichiro Kuwahara; Tetsuo Shioi; Takeshi Kimura
ESC Heart Failure, 4(3), 216-223, Aug. 2017
Lead

Impact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model
Tatsuki Ogasawara; Satomi Okano; Hajime Ichimura; Shin Kadota; Yuki Tanaka; Itsunari Minami; Motonari Uesugi; Yuko Wada; Naoto Saito; Kenji Okada; Koichiro Kuwahara; Yuji Shiba
SCIENTIFIC REPORTS, 7, Aug. 2017, Refereed, Not invited
Lead

Omecamtiv mecarbil
木村 和広; 桑原 宏一郎;
循環器内科 = Cardioangiology, 82(2), 169-172, Aug. 2017

Diagnostic advantage of stress computed tomography myocardial perfusion over single-photon emission computed tomography for the assessment of myocardial ischemia
Yasushi Ueki; Atsushi Izawa; Daisuke Kashiwagi; Shigeki Nishiyama; Shinichi Aso; Chihiro Suzuki; Shumpei Sakurai; Kazuhiro Oguchi; Yoshikazu Yazaki; Uichi Ikeda; Koichiro Kuwahara
JOURNAL OF CARDIOLOGY, 70(1-2), 147-154, Jul. 2017
Lead

B-Type Natriuretic Peptide in Heart Failure With Preserved Ejection Fraction
Eisaku Harada; Yuji Mizuno; Fumihito Kugimiya; Makoto Shono; Hiroyuki Maeda; Naotsugu Yano; Koichiro Kuwahara; Hirofumi Yasue
CIRCULATION JOURNAL, 81(7), 1006-+, Jul. 2017, Refereed, Not invited
Lead

Impressive predictive value of ankle-brachial index for very long-term outcomes in patients with cardiovascular disease: IMPACT-ABI study
Takashi Miura; Masatoshi Minamisawa; Yasushi Ueki; Naoyuki Abe; Hitoshi Nishimura; Naoto Hashizume; Tomoaki Mochidome; Mikiko Harada; Yasutaka Oguchi; Koji Yoshie; Wataru Shoin; Tatsuya Saigusa; Soichiro Ebisawa; Hirohiko Motoki; Jun Koyama; Uichi Ikeda; Koichiro Kuwahara
PLOS ONE, 12(6), Jun. 2017
Lead

Prevention of abdominal aortic aneurysm progression by oral administration of green tea polyphenol in a rat model
Shuji Setozaki; Kenji Minakata; Hidetoshi Masumoto; Shingo Hirao; Kazuhiro Yamazaki; Koichiro Kuwahara; Tadashi Ikeda; Ryuzo Sakata
JOURNAL OF VASCULAR SURGERY, 65(6), 1803-1812, Jun. 2017, Refereed, Not invited
Lead

O結合型オリゴ糖付着は血液透析(HD)中の心不全(HF)と慢性腎不全(CRF)におけるN末端proBNP値を過小評価する(O-linked Oligosaccharide Attachment Underestimates N-terminal proBNP(NT-BNP) Levels in Heart Failure(HF) and Chronic Renal Failure(CRF) on Hemodialysis(HD))
Nishikimi Toshio; Nakagawa Yasuaki; Kuwahara Koichiro; Kinoshita Hideyuki; Inazumi Hideaki; Moriuchi Kenji; Nakao Kazuwa; Kimura Takeshi
日本循環器学会学術集会抄録集, 81回, OE-250, Mar. 2017
Lead

MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts
Yasuaki Nakagawa; Toshio Nishikimi; Koichiro Kuwahara; Aoi Fujishima; Shogo Oka; Takayoshi Tsutamoto; Hideyuki Kinoshita; Kazuhiro Nakao; Kosai Cho; Hideaki Inazumi; Hiroyuki Okamoto; Motohiro Nishida; Takao Kato; Hiroyuki Fukushima; Jun K. Yamashita; Wino J. Wijnen; Esther E. Creemers; Kenji Kangawa; Naoto Minamino; Kazuwa Nakao; Takeshi Kimura
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 6(2), Feb. 2017, Refereed, Not invited
Lead

MiR30-GALNT1/2 axis-mediated glycosylation contributes to the increased secretion of inactive human pro-BNP from failing hearts
Nakagawa Y; Nishikimi T; Kuwahara K; Fujishima A; Oka S; Tsutamoto T; Kinoshita H; Nakao K; Cho K; Inazumi H; Okamoto H; Nishida M; Kato T; Fukushima H; Yamashita J; Wijnen WJ; Creemers EE; Kangawa K; Minamino N; Nakao K; Kimura T
JAHA, 6, e003601, Feb. 2017, Refereed, Not invited
Lead

病的心筋におけるmiR30-GALNT経路による糖鎖修飾を介したproBNP分泌制御
中川 靖章; 錦見 俊雄; 桑原 宏一郎; 木下 秀之; 稲住 英明; 森内 健史; 南野 直人; 中尾 一和; 木村 剛
日本内分泌学会雑誌, 92(3), 896-896, Jan. 2017
Lead

Unique angiographic findings in a patient with myocardial ischemia and immunoglobulin G4-related disease
Yusuke Kanzaki; Takashi Miura; Naoto Hashizume; Tatsuya Saigusa; Soichiro Ebisawa; Koichiro Kuwahara
SAGE OPEN MEDICAL CASE REPORTS, 5, Jan. 2017
Lead

Increase of Total Nephron Albumin Filtration and Reabsorption in Diabetic Nephropathy
Keita P. Mori; Hideki Yokoi; Masato Kasahara; Hirotaka Imamaki; Akira Ishii; Takashige Kuwabara; Kenichi Koga; Yukiko Kato; Naohiro Toda; Shoko Ohno; Koichiro Kuwahara; Tomomi Endo; Kazuwa Nakao; Motoko Yanagita; Masashi Mukoyama; Kiyoshi Mori
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 28(1), 278-289, Jan. 2017, Refereed, Not invited
Lead

Ankle-brachial Index for the Prognosis of Cardiovascular Disease in Patients with Mild Renal Insufficiency
Hitoshi Nishimura; Takashi Miura; Masatoshi Minamisawa; Yasushi Ueki; Naoyuki Abe; Naoto Hashizume; Tomoaki Mochidome; Mikiko Harada; Kunihiko Shimizu; Wataru Shoin; Koji Yoshie; Yasutaka Oguchi; Soichiro Ebisawa; Hirohiko Motoki; Atsushi Izawa; Jun Koyama; Uichi Ikeda; Koichiro Kuwahara
INTERNAL MEDICINE, 56(16), 2103-2111, 2017, Refereed, Not invited
Lead

Endothelium-Derived C-Type Natriuretic Peptide Contributes to Blood Pressure Regulation by Maintaining Endothelial Integrity
Nakao K; Kuwahara K; Nishikimi T; Nakagawa Y; Kinoshita H; Minami T; Kuwabara Y; Yamada C; Yamada Y; Tokudome T
Hypertension, 69(2), 286-296, 2017, Refereed, Not invited
Lead

TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis
Takuro Numaga-Tomita; Naoyuki Kitajima; Takuya Kuroda; Akiyuki Nishimura; Kei Miyano; Satoshi Yasuda; Koichiro Kuwahara; Yoji Sato; Tomomi Ide; Lutz Birnbaumer; Hideki Sumimoto; Yasuo Mori; Motohiro Nishida
SCIENTIFIC REPORTS, 6, 39383, Dec. 2016, Refereed, Not invited
Lead

Adrenomedullin
T. Nishikimi; K. Kuwahara; Y. Nakagawa; K. Kangawa; K. Nakao
Endocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart, 41-58, Nov. 2016, Refereed, Not invited
Lead

Clinical Characteristics and Outcomes of Patients with High Ankle-Brachial Index from the IMPACT-ABI Study
Hitoshi Nishimura; Takashi Miura; Masatoshi Minamisawa; Yasushi Ueki; Naoyuki Abe; Naoto Hashizume; Tomoaki Mochidome; Mikiko Harada; Kunihiko Shimizu; Wataru Shoin; Koji Yoshie; Yasutaka Oguchi; Soichiro Ebisawa; Hirohiko Motoki; Atsushi Izawa; Jun Koyama; Uichi Ikeda; Koichiro Kuwahara
PLOS ONE, 11(11), Nov. 2016
Lead

TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling
Naoyuki Kitajima; Takuro Numaga-Tomita; Masahiko Watanabe; Takuya Kuroda; Akiyuki Nishimura; Kei Miyano; Satoshi Yasuda; Koichiro Kuwahara; Yoji Sato; Tomomi Ide; Lutz Birnbaumer; Hideki Sumimoto; Yasuo Mori; Motohiro Nishida
SCIENTIFIC REPORTS, 6, 37001, Nov. 2016, Refereed, Not invited
Lead

Brain-specific natriuretic peptide receptor-B deletion attenuates high-fat diet-induced visceral and hepatic lipid deposition in mice
Yui Yamashita; Nobuko Yamada-Goto; Goro Katsuura; Yukari Ochi; Yugo Kanai; Yuri Miyazaki; Koichiro Kuwahara; Naotetsu Kanamoto; Masako Miura; Akihiro Yasoda; Kousaku Ohinata; Nobuya Inagaki; Kazuwa Nakao
PEPTIDES, 81, 38-50, Jul. 2016, Not invited
Lead

Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure
Shoko Ohno; Hideki Yokoi; Kiyoshi Mori; Masato Kasahara; Koichiro Kuwahara; Junji Fujikura; Masaki Naito; Takashige Kuwabara; Hirotaka Imamaki; Akira Ishii; Moin A. Saleem; Tomohiro Numata; Yasuo Mori; Kazuwa Nakao; Motoko Yanagita; Masashi Mukoyama
SCIENTIFIC REPORTS, 6, Jun. 2016, Not invited
Lead

O型糖転移酵素GALNTのBNPプロセシング調節への関与
中川 靖章; 錦見 俊雄; 桑原 宏一郎; 木下 秀之; 山田 千夏; 稲住 英明; 南野 直人; 中尾 一和; 木村 剛
日本内分泌学会雑誌, 92(1), 256-256, Apr. 2016
Lead

miR30-GALNT経路によるO型糖鎖修飾を介したBNPプロセシング調節が病的心筋からのproBNP分泌亢進に寄与する
中川 靖章; 錦見 俊雄; 桑原 宏一郎; 保野 慎治; 木下 秀之; 桑原 佳宏; 山田 千夏; 稲住 英明; 上嶋 健治; 南野 直人; 中尾 一和; 木村 剛
日本臨床分子医学会学術総会プログラム・抄録集, 53回, 75-75, Apr. 2016
Lead

心不全および不整脈突然死マウスにおいてrenin-angiotensin系の不整脈原性基質促進に対する重大な関与(Significant Contribution of Renin-angiotensin System to Promoting Arrhythmogenic Substrates in Mice with Heart Failure and Sudden Arrhythmic Death)
Yamada Chinatsu; Kuwahara Koichiro; Inazumi Hideaki; Kinoshita Hideyuki; Nakagawa Yasuaki; Nishikimi Toshio; Nakao Kazuwa; Kimura Takeshi
Circulation Journal, 80(Suppl.I), 1251-1251, Mar. 2016
Lead

The renin-angiotensin system promotes arrhythmogenic substrates and lethal arrhythmias in mice with non-ischaemic cardiomyopathy
Chinatsu Yamada; Koichiro Kuwahara; Masatoshi Yamazaki; Yasuaki Nakagawa; Toshio Nishikimi; Hideyuki Kinoshita; Yoshihiro Kuwabara; Takeya Minami; Yuko Yamada; Junko Shibata; Kazuhiro Nakao; Kosai Cho; Yuji Arai; Haruo Honjo; Kaichiro Kamiya; Kazuwa Nakao; Takeshi Kimura
CARDIOVASCULAR RESEARCH, 109(1), 162-173, Jan. 2016, Not invited
Lead

Myocardial Strain by 2-Dimensional Speckle Tracking Echocardiography IsUseful to Elucidate the Cause of Mitral Regurgitation in a Case of CardiacSarcoidosis
Yoneda Tomoya; Kinoshita Hideyuki; Handa Tomohiro; Nagai Sonoko; Aizawa Takanori; Okabayashi Marie; Nakashima Yasuhiro; Nakagawa Yasuaki; Kuwahara Kouichirou; Ichiyama Satoshi; Kimura Takeshi
The Japanese Journal of Sarcoidosis and Other Granulomatous Disorders, 36(1), 79-83, 2016
Lead

Differential Relationships Between Anemia and Outcome in Subgroups of Patients With Chronic Heart Failure
Yasuaki Nakagawa; Shinji Yasuno; Koichiro Kuwahara
CIRCULATION JOURNAL, 79(9), 1893-1894, Sep. 2015, Not invited
Lead

Pro-B-type natriuretic peptide is cleaved intracellularly: impact of distance between O-glycosylation and cleavage sites
Toshio Nishikimi; Yasuaki Nakagawa; Naoto Minamino; Masashi Ikeda; Kyoko Tabei; Aoi Fujishima; Kentaro Takayama; Kazumi Akimoto; Chinatsu Yamada; Kazuhiro Nakao; Takeya Minami; Yoshihiro Kuwabara; Hideyuki Kinoshita; Takayoshi Tsutamoto; Toshihiko Ishimitsu; Kenji Kangawa; Koichiro Kuwahara; Kazuwa Nakao
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 309(6), R639-R649, Sep. 2015, Not invited
Lead

The organ-protective effect of N-type Ca2+ channel blockade
Koichiro Kuwahara; Takeshi Kimura
PHARMACOLOGY & THERAPEUTICS, 151, 1-7, Jul. 2015, Not invited
Lead

The Local CNP/GC-B system in growth plate is responsible for physiological endochondral bone growth
Kazumasa Nakao; Kenji Osawa; Akihiro Yasoda; Shigeki Yamanaka; Toshihito Fujii; Eri Kondo; Noriaki Koyama; Naotetsu Kanamoto; Masako Miura; Koichiro Kuwahara; Haruhiko Akiyama; Kazuhisa Bessho; Kazuwa Nakao
SCIENTIFIC REPORTS, 5, May 2015, Not invited
Lead

Ectopic automaticity induced in ventricular myocytes by transgenic overexpression of HCN2
Kensuke Oshita; Masayuki Ltoh; Shingo Hirashima; Yoshihiro Kuwabara; Keiko Lshihara; Koichiro Kuwahara; Kazuwa Nakao; Takeshi Kimura; Kei-ichiro Nakamura; Kazuo Ushijima; Makoto Takano
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 80, 81-89, Mar. 2015, Not invited
Lead

シルニジピンによる糖尿病性腎症の進行抑制機序の検討
大野 祥子; 横井 秀基; 笠原 正登; 森 潔; 桑原 宏一郎; 塩田 文彦; 菅原 照; 中尾 一和; 柳田 素子; 向山 政志
日本内科学会雑誌, 104(Suppl.), 264-264, Feb. 2015
Lead

Somatic chromosomal translocation between Ewsr1 and Fli1 loci leads to dilated cardiomyopathy in a mouse model
Miwa Tanaka; Shuichi Yamaguchi; Yukari Yamazaki; Hideyuki Kinoshita; Koichiro Kuwahara; Kazuwa Nakao; Patrick Y. Jay; Tetsuo Noda; Takuro Nakamura
SCIENTIFIC REPORTS, 5, Jan. 2015, Not invited
Lead

TRP Channels: Their Function and Potentiality as Drug Targets
Motohiro Nishida; Koichiro Kuwahara; Daisuke Kozai; Reiko Sakaguchi; Yasuo Mori
195-218, 2015
Lead

僧帽弁逆流の成因解明にストレインエコーが有用であった心サルコイドーシスの一症例
米田 智也; 木下 秀之; 半田 知宏; ⻑井 苑子; 相澤 卓範; 岡林 真梨恵; 中島 康弘; 中川 靖章; 桑原 宏一郎; 一山 智; 木村 剛
日本サルコイドーシス／肉芽腫性疾患学会雑誌, 35(1), 69-3-69-3, 2015
Lead

僧帽弁逆流の成因解明にストレインエコーが有用であった心サルコイドーシスの1症例
米田智也; 木下秀之; 相澤卓範; 岡林真梨恵; 中島康弘; 山田千夏; 今井逸雄; 中川靖章; 静田聡; 桑原宏一郎; 尾野亘; 一山智; 木村剛
日本循環器学会近畿地方会(Web), 120th, KINKI120,C25 (WEB ONLY), 2015, Not invited
Lead

肺胞蛋白症に肺高血圧症を合併した一例
北野一樹; 木下秀之; 谷澤公伸; 大原弘喜; 辰島正二郎; 山田千夏; 中川靖章; 静田聡; 桑原宏一郎; 尾野亘; 木村剛
日本循環器学会近畿地方会(Web), 120th, KINKI120,H22 (WEB ONLY), 2015, Not invited
Lead

Inhibition of N-type Ca2+ channels ameliorates an imbalance in cardiac autonomic nerve activity and prevents lethal arrhythmias in mice with heart failure
Yuko Yamada; Hideyuki Kinoshita; Koichiro Kuwahara; Yasuaki Nakagawa; Yoshihiro Kuwabara; Takeya Minami; Chinatsu Yamada; Junko Shibata; Kazuhiro Nakao; Kosai Cho; Yuji Arai; Shinji Yasuno; Toshio Nishikimi; Kenji Ueshima; Shiro Kamakura; Motohiro Nishida; Shigeki Kiyonaka; Yasuo Mori; Takeshi Kimura; Kenji Kangawa; Kazuwa Nakao
CARDIOVASCULAR RESEARCH, 104(1), 183-193, Oct. 2014, Not invited
Lead

The Effects of Super-Flux (High Performance) Dialyzer on Plasma Glycosylated Pro-B-Type Natriuretic Peptide (proBNP) and Glycosylated N-Terminal proBNP in End-Stage Renal Disease Patients on Dialysis
Yasuaki Nakagawa; Toshio Nishikimi; Koichiro Kuwahara; Shinji Yasuno; Hideyuki Kinoshita; Yoshihiro Kuwabara; Kazuhiro Nakao; Takeya Minami; Chinatsu Yamada; Kenji Ueshima; Yoshihiro Ikeda; Hiroyuki Okamoto; Kazukiyo Horii; Kiyoshi Nagata; Kenji Kangawa; Naoto Minamino; Kazuwa Nakao
PLOS ONE, 9(3), Mar. 2014, Not invited
Lead

全身性強皮症に合併した肺高血圧症に対し原因の鑑別を行った1症例
脊古裕太; 木下秀之; 山田千夏; 中川靖章; 静田聡; 尾野亘; 塩井哲雄; 桑原宏一郎; 木村剛
日本循環器学会近畿地方会(Web), 118th, KINKI118,F30 (WEB ONLY), 2014, Not invited
Lead

Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy
Shinji Yasuno; Koichiro Kuwahara; Hideyuki Kinoshita; Chinatsu Yamada; Yasuaki Nakagawa; Satoru Usami; Yoshihiro Kuwabara; Kenji Ueshima; Masaki Harada; Toshio Nishikimi; Kazuwa Nakao
BRITISH JOURNAL OF PHARMACOLOGY, 170(7), 1384-1395, Dec. 2013, Not invited
Lead

Identification of chemicals inducing cardiomyocyte proliferation in developmental stage-specific manner with pluripotent stem cells
Hideki Uosaki; Ajit Magadum; Kinya Seo; Hiroyuki Fukushima; Ayako Takeuchi; Yasuaki Nakagawa; Kara White Moyes; Genta Narazaki; Koichiro Kuwahara; Michael Laflamme; Satoshi Matsuoka; Norio Nakatsuji; Kazuwa Nakao; Chulan Kwon; David A. Kass; Felix B. Engel; Jun K. Yamashita
Circulation: Cardiovascular Genetics, 6(6), 624-633, Dec. 2013, Refereed, Not invited
Lead

Cardiac nuclear high mobility group box 1 prevents the development of cardiac hypertrophy and heart failure
Akira Funayama; Tetsuro Shishido; Shunsuke Netsu; Taro Narumi; Shinpei Kadowaki; Hiroki Takahashi; Takuya Miyamoto; Tetsu Watanabe; Chang-Hoon Woo; Jun-ichi Abe; Koichiro Kuwahara; Kazuwa Nakao; Yasuchika Takeishi; Isao Kubota
CARDIOVASCULAR RESEARCH, 99(4), 657-664, Sep. 2013, Not invited
Lead

Angiotensin II-induced cardiac hypertrophy and fibrosis are promoted in mice lacking Fgf16
Emi Matsumoto; Sayaka Sasaki; Hideyuki Kinoshita; Takuya Kito; Hiroya Ohta; Morichika Konishi; Koichiro Kuwahara; Kazuwa Nakao; Nobuyuki Itoh
GENES TO CELLS, 18(7), 544-553, Jul. 2013, Not invited
Lead

Increased Expression of HCN Channels in the Ventricular Myocardium Contributes to Enhanced Arrhythmicity in Mouse Failing Hearts
Yoshihiro Kuwabara; Koichiro Kuwahara; Makoto Takano; Hideyuki Kinoshita; Yuji Arai; Shinji Yasuno; Yasuaki Nakagawa; Sachiyo Igata; Satoru Usami; Takeya Minami; Yuko Yamada; Kazuhiro Nakao; Chinatsu Yamada; Junko Shibata; Toshio Nishikimi; Kenji Ueshima; Kazuwa Nakao
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2(3), Jun. 2013, Not invited
Lead

Voltage-dependent N-type Ca2+ channels in endothelial cells contribute to oxidative stress-related endothelial dysfunction induced by angiotensin II in mice
Motohiro Nishida; Tatsuya Ishikawa; Shota Saiki; Caroline Sunggip; Shizuka Aritomi; Eri Harada; Koichiro Kuwahara; Katsuya Hirano; Yasuo Mori; Shokei Kim-Mitsuyama
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 434(2), 210-216, May 2013, Not invited
Lead

Complexity of molecular forms of B-type natriuretic peptide in heart failure
Toshio Nishikimi; Koichiro Kuwahara; Yasuaki Nakagawa; Kenji Kangawa; Naoto Minamino; Kazuwa Nakao
HEART, 99(10), 677-679, May 2013, Refereed, Not invited
Lead

Direct Immunochemiluminescent Assay for proBNP and Total BNP in Human Plasma proBNP and Total BNP Levels in Normal and Heart Failure
Toshio Nishikimi; Hiroyuki Okamoto; Masahiro Nakamura; Naoko Ogawa; Kazukiyo Horii; Kiyoshi Nagata; Yasuaki Nakagawa; Hideyuki Kinoshita; Chinatsu Yamada; Kazuhiro Nakao; Takeya Minami; Yoshihiro Kuwabara; Koichiro Kuwahara; Izuru Masuda; Kenji Kangawa; Naoto Minamino; Kazuwa Nakao
PLOS ONE, 8(1), Jan. 2013, Not invited
Lead

Determination of the B-type natriuretic peptide level as a criterion for abnormalities in Japanese individuals in routine clinical practice: The J-ABS multi-center study (Japan Abnormal BNP Standard)
Makoto Kawai; Michihiro Yoshimura; Masaki Harada; Yuji Mizuno; Shinya Hiramitsu; Mitsuyuki Shimizu; Toru Shoda; Koichiro Kuwahara; Kenji Miyagishima; Kenji Ueshima; Kazuwa Nakao
Internal Medicine, 52(2), 171-177, 2013, Not invited
Lead

Role of NRSF/REST in the regulation of cardiac gene expression and function
Koichiro Kuwahara
Circulation Journal, 77(11), 2682-2686, 2013, Not invited
Lead

Adrenomedullin in cardiovascular disease: A useful biomarker, its pathological roles and therapeutic application
Toshio Nishikimi; Koichiro Kuwahara; Yasuaki Nakagawa; Kenji Kangawa; Kazuwa Nakao
Current Protein and Peptide Science, 14(4), 256-267, 2013, Not invited
Lead

Ca²⁺ channels as novel therapeutic targets in heart failure
K. Kuwahara
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 140(6), 255-258, Dec. 2012, Refereed, Not invited
Lead

Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice
Takeya Minami; Koichiro Kuwahara; Yasuaki Nakagawa; Minoru Takaoka; Hideyuki Kinoshita; Kazuhiro Nakao; Yoshihiro Kuwabara; Yuko Yamada; Chinatsu Yamada; Junko Shibata; Satoru Usami; Shinji Yasuno; Toshio Nishikimi; Kenji Ueshima; Masataka Sata; Hiroyasu Nakano; Takahiro Seno; Yutaka Kawahito; Kenji Sobue; Akinori Kimura; Ryozo Nagai; Kazuwa Nakao
EMBO JOURNAL, 31(23), 4428-4440, Nov. 2012, Refereed, Not invited
Lead

[109th Scientific Meeting of the Japanese Society of Internal Medicine: symposium: 2. Translational research and evidence-based medicine (EBM) in internal medicine in Japan, translational research; 4) Translational research of endocrinology and metabolism
Kiminori Hosoda; Akihiro Yasoda; Ken Ebihara; Koichiro Kuwahara; Masashi Mukouyama; Kazuwa Nakao
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 101, 2552-2562, Sep. 2012, Not invited
Lead

In vivo Site-Specific Transfection of Naked Plasmid DNA and siRNAs in Mice by Using a Tissue Suction Device
Kazunori Shimizu; Shigeru Kawakami; Kouji Hayashi; Hideyuki Kinoshita; Koichiro Kuwahara; Kazuwa Nakao; Mitsuru Hashida; Satoshi Konishi
PLOS ONE, 7(7), Jul. 2012, Refereed, Not invited
Lead

Transcriptional Regulation of the Fetal Cardiac Gene Program
Koichiro Kuwahara; Toshio Nishikimi; Kazuwa Nakao
JOURNAL OF PHARMACOLOGICAL SCIENCES, 119(3), 198-203, Jul. 2012, Refereed, Not invited
Lead

Fixed-dose combination therapy of candesartan cilexetil and amlodipine besilate for the treatment of hypertension in Japan
Shinji Yasuno; Akira Fujimoto; Yasuaki Nakagawa; Koichiro Kuwahara; Kenji Ueshima
Expert Review of Cardiovascular Therapy, 10(5), 577-583, May 2012, Refereed, Not invited
Lead

Current biochemistry, molecular biology, and clinical relevance if natriuretic peptides (vol 57, pg 131, 2011)
Toshio Nishikimi; Koichiro Kuwahara; Kazuwa Nakao
JOURNAL OF CARDIOLOGY, 59(1), 98-99, Jan. 2012, Refereed, Not invited
Lead

The effect of glycosylation on plasma N-terminal proBNP-76 levels in patients with heart or renal failure
Toshio Nishikimi; Masashi Ikeda; Yosuke Takeda; Toshihiko Ishimitsu; Ikuko Shibasaki; Hirotsugu Fukuda; Hideyuki Kinoshita; Yasuaki Nakagawa; Koichiro Kuwahara; Kazuwa Nakao
HEART, 98(2), 152-161, Jan. 2012, Refereed, Not invited
Lead

ユーイング肉腫特異的なEws-Fli1転座マウスは拡張型心筋症を発症する(A mouse model for Ewing's sarcoma-specific Ews-Fli1 so matic translocation develops dilated cardiomyopathy)
田中 美和; 野田 哲生; 木下 秀之; 桑原 宏一郎; 中尾 一和; 中村 卓郎
日本癌学会総会記事, 70回, 159-159, Sep. 2011, Refereed, Not invited
Lead

TRPC3/6 as Potentially Novel Therapeutic Targets for The Treatment of Pulmonary Arterial Hypertension
Hideyuki Kinoshita; Koichiro Kuwahara; Shigeki Kiyonaka; Yasuo Mori; Yoshihiro Kuwabara; Satoru Usami; Yasuaki Nakagawa; Toshio Nishikimi; Kenji Ueshima; Kazuwa Nakao
JOURNAL OF CARDIAC FAILURE, 17(9), S153, Sep. 2011, Refereed, Not invited
Lead

New Molecular Mechanisms for Cardiovascular Disease: Transcriptional Pathways and Novel Therapeutic Targets in Heart Failure
Koichiro Kuwahara; Kazuwa Nakao
JOURNAL OF PHARMACOLOGICAL SCIENCES, 116(4), 337-342, Aug. 2011, Refereed, Not invited
Lead

Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes
Leo Hata; Masao Murakami; Koichiro Kuwahara; Yasuaki Nakagawa; Hideyuki Kinoshita; Satoru Usami; Shinji Yasuno; Masataka Fujiwara; Yoshihiro Kuwabara; Takeya Minami; Yuko Yamada; Chinatsu Yamada; Kazuhiro Nakao; Kenji Ueshima; Toshio Nishikimi; Kazuwa Nakao
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 50(6), 972-981, Jun. 2011, Refereed, Not invited
Lead

Current biochemistry, molecular biology, and clinical relevance of natriuretic peptides
Toshio Nishikimi; Koichiro Kuwahara; Kazuwa Nakao
JOURNAL OF CARDIOLOGY, 57(2), 131-140, Mar. 2011, Refereed, Not invited
Lead

Induction and Enhancement of Cardiac Cell Differentiation from Mouse and Human Induced Pluripotent Stem Cells with Cyclosporin-A
Masataka Fujiwara; Peishi Yan; Tomomi G. Otsuji; Genta Narazaki; Hideki Uosaki; Hiroyuki Fukushima; Koichiro Kuwahara; Masaki Harada; Hiroyuki Matsuda; Satoshi Matsuoka; Keisuke Okita; Kazutoshi Takahashi; Masato Nakagawa; Tadashi Ikeda; Ryuzo Sakata; Christine L. Mummery; Norio Nakatsuji; Shinya Yamanaka; Kazuwa Nakao; Jun K. Yamashita
PLOS ONE, 6(2), e16734, Feb. 2011, Refereed, Not invited
Lead

N-Type Ca2+ Channel Blockade Prevents Sudden Death in Mice with Heart Failure
Yuko Yamada; Koichiro Kuwahara; Hideyuki Kinoshita; Yoshihiro Kuwabara; Yasuaki Nakagawa; Junko Shibata; Chinatsu Yamada; Takeya Minami; Satoshi Usami; Kazuyasu Nakao; Toshio Nishikimi; Kazuwa Nakao
journal of arrhythmia, 27(4), 209, 2011, Refereed, Not invited
Lead

Inhibition of HCN Overexpressed in Failing Heart of Dilated Cardiomyopathy Mouse Model by Ivabradine Prevents Sudden Arrhythmic Death
Yoshihiro Kuwabara; Koichiro Kuwahara; Makoto Takano; Hidayuki Kinoshita; Yasuaki Nakagawa; Satoru Usami; Kazuhiro Nakao; Takeya Minami; Toshio Nishikimi; Kazuwa Nakao
journal of arrhythmia, 27(4), 424, 2011, Refereed, Not invited
Lead

G alpha(12/13) mediate pressure overload-induced cardiac fibrosis through 4-hydroxy-2-nonenal production in cardiac fibroblasts
Takashi Mishima; Motohiro Nishida; Koichiro Kuwahara; Michio Nakaya; Yoji Sato; Takahiro Shibata; Koji Uchida; Hitoshi Kurose
JOURNAL OF PHARMACOLOGICAL SCIENCES, 115, 203P-203P, 2011, Refereed, Not invited
Lead

Pathophysiological Remodeling of Mouse Cardiac Myocytes Expressing Dominant Negative Mutant of Neuron Restrictive Silencing Factor
Makoto Takano; Hideyuki Kinoshita; Takao Shioya; Masayuki Itoh; Kazuwa Nakao; Koichiro Kuwahara
CIRCULATION JOURNAL, 74(12), 2712-2719, Dec. 2010, Refereed, Not invited
Lead

Natriuretic Peptides-Guanylyl Cyclase-A Signaling Pathway Inhibits TRPC6-Mediated Pro-Hypertrophic Signaling in the Hearts
Kinoshita Hideyuki; Kuwahara Koichiro; Nishida Motohiro; Kurose Hitoshi; Zhong Jian; Inoue Ryuji; Kiyonaka Shigeki; Mori Yasuo; Rong Xianglu; Li Yuhao; Yamada Chinatsu; Yamada Yuko; Minami Takeya; Kuwabara Yoshihiro; Fujiwara Masataka; Yasuno Shinji; Usami Satoru; Nakagawa Yasuaki; Nishikimi Toshio; Ueshima Kenji; Nakao Kazuwa
CIRCULATION, 122(21), Nov. 2010, Refereed, Not invited
Lead

Blockade of TRPC6 is a Novel Therapeutic Approach Against Pathological Cardiac Remodeling
Hideyuki Kinoshita; Koichiro Kuwahara; Motohiro Nishida; Hitoshi Kurose; Shigeki Kiyonaka; Yasuo Mori; Satoru Usami; Yasuaki Nakagawa; Kenji Ueshima; Kazuwa Nakao
JOURNAL OF CARDIAC FAILURE, 16(9), Sep. 2010, Not invited
Lead

Myocardin-Related Transcription Factor A Is a Common Mediator of Mechanical Stress- and Neurohumoral Stimulation-Induced Cardiac Hypertrophic Signaling Leading to Activation of Brain Natriuretic Peptide Gene Expression
Koichiro Kuwahara; Hideyuki Kinoshita; Yoshihiro Kuwabara; Yasuaki Nakagawa; Satoru Usami; Takeya Minami; Yuko Yamada; Masataka Fujiwara; Kazuwa Nakao
MOLECULAR AND CELLULAR BIOLOGY, 30(17), 4134-4148, Sep. 2010, Refereed, Not invited
Lead

Angiotensin II type 1 receptor-independent beneficial effects of telmisartan on dietary-induced obesity, insulin resistance and fatty liver in mice
X. Rong; Y. Li; K. Ebihara; M. Zhao; J. Naowaboot; T. Kusakabe; K. Kuwahara; M. Murray; K. Nakao
DIABETOLOGIA, 53(8), 1727-1731, Aug. 2010, Refereed, Not invited
Lead

Podocyte-specific expression of tamoxifen-inducible Cre recombinase in mice
Hideki Yokoi; Masato Kasahara; Masashi Mukoyama; Kiyoshi Mori; Koichiro Kuwahara; Junji Fujikura; Yuji Arai; Yoko Saito; Yoshihisa Ogawa; Takashige Kuwabara; Akira Sugawara; Kazuwa Nakao
NEPHROLOGY DIALYSIS TRANSPLANTATION, 25(7), 2120-2124, Jul. 2010, Refereed, Not invited
Lead

Regulation and significance of atrial and brain natriuretic peptides as cardiac hormones
Koichiro Kuwahara; Kazuwa Nakao
ENDOCRINE JOURNAL, 57(7), 555-565, Jul. 2010, Refereed, Not invited
Lead

Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction
Eric M. Small; Jeffrey E. Thatcher; Lillian B. Sutherland; Hideyuki Kinoshita; Robert D. Gerard; James A. Richardson; J. Michael DiMaio; Hesham Sadek; Koichiro Kuwahara; Eric N. Olson
CIRCULATION RESEARCH, 107(2), 294-U263, Jul. 2010, Refereed, Not invited
Lead

Inhibition of TRPC6 Channel Activity Contributes to the Antihypertrophic Effects of Natriuretic Peptides-Guanylyl Cyclase-A Signaling in the Heart
Hideyuki Kinoshita; Koichiro Kuwahara; Motohiro Nishida; Zhong Jian; Xianglu Rong; Shigeki Kiyonaka; Yoshihiro Kuwabara; Hitoshi Kurose; Ryuji Inoue; Yasuo Mori; Yuhao Li; Yasuaki Nakagawa; Satoru Usami; Masataka Fujiwara; Yuko Yamada; Takeya Minami; Kenji Ueshima; Kazuwa Nakao
CIRCULATION RESEARCH, 106(12), 1849-U153, Jun. 2010, Refereed, Not invited
Lead

Atrial and brain natriuretic peptides-guanylyl cyclase-A signaling pathway inhibits TRPC6-mediated pro-hypertrophic signaling in the hearts
Hideyuki Kinoshita; Koichiro Kuwahara; Motohiro Nishida; Zhong Jiang; Xianglu Rong; Shigeki Kiyonaka; Yoshihiro Kuwabara; Hitoshi Kurose; Ryuji Inoue; Yasuo Mori; Yuhao Li; Yasuaki Nakagawa; Satoru Usami; Kenji Ueshima; Kazuwa Nakao
ENDOCRINE JOURNAL, 57, Mar. 2010, Not invited
Lead

Vasodilator therapy with hydralazine induces angiotensin AT(2) receptor-mediated cardiomyocyte growth in mice lacking guanylyl cyclase-A
Y. Li; Y. Saito; K. Kuwahara; X. Rong; I. Kishimoto; M. Harada; M. Horiuchi; M. Murray; K. Nakao
BRITISH JOURNAL OF PHARMACOLOGY, 159(5), 1133-1142, Mar. 2010, Refereed, Not invited
Lead

p300 Plays a Critical Role in Maintaining Cardiac Mitochondrial Function and Cell Survival in Postnatal Hearts
Yasuaki Nakagawa; Koichiro Kuwahara; Genzo Takemura; Masaharu Akao; Masashi Kato; Yuji Arai; Makoto Takano; Masaki Harada; Masao Murakami; Michio Nakanishi; Satoru Usami; Shinji Yasuno; Hideyuki Kinoshita; Masataka Fujiwara; Kenji Ueshima; Kazuwa Nakao
CIRCULATION RESEARCH, 105(8), 746-U57, Oct. 2009, Refereed, Not invited
Lead

Cardiac Natriuretic Peptides Inhibit TRPC6-Mediated Prohypertrophic Signaling
Hideyuki Kinoshita; Koichiro Kuwahara; Ryuji Inoue; Motohiro Nishida; Hitoshi Kurose; Shigeki Kiyonaka; Yasuo Mori; Masaki Harada; Masao Murakami; Yasuaki Nakagawa; Shinji Yasuno; Satoru Usami; Masataka Fujiwara; Yoshihiro Kuwabara; Takeya Minami; Yuko Yamada; Kenji Ueshima; Kazuwa Nakao
CIRCULATION RESEARCH, 105(7), E47, Sep. 2009, Refereed, Not invited
Lead

T-Type Ca2+ Channel Blockade Prevents Sudden Death in Mice With Heart Failure
Hideyuki Kinoshita; Koichiro Kuwahara; Makoto Takano; Yuji Arai; Yoshihiro Kuwabara; Shinji Yasuno; Yasuaki Nakagawa; Michio Nakanishi; Masaki Harada; Masataka Fujiwara; Masao Murakami; Kenji Ueshima; Kazuwa Nakao
CIRCULATION, 120(9), 743-U66, Sep. 2009, Refereed, Not invited
Lead

The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2
Shinobu Kuratomi; Yoko Ohmori; Masayuki Ito; Kuniko Shimazaki; Shin-ichi Muramatsu; Hiroaki Mizukami; Hideki Uosaki; Jun K. Yamashita; Yuji Arai; Koichiro Kuwahara; Makoto Takano
CARDIOVASCULAR RESEARCH, 83(4), 682-687, Sep. 2009, Refereed, Not invited
Lead

The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2
Shinobu Kuratomi; Yoko Ohmori; Masayuki Ito; Kuniko Shimazaki; Shin-ichi Muramatsu; Hiroaki Mizukami; Hideki Uosaki; Jun K. Yamashita; Yuji Arai; Koichiro Kuwahara; Makoto Takano
CARDIOVASCULAR RESEARCH, 83(4), 682-687, Sep. 2009, Refereed, Not invited
Lead

Guanylyl Cyclase-A Inhibits Angiotensin II Type 2 Receptor-Mediated Pro-Hypertrophic Signaling in the Heart
Yuhao Li; Yoshihiko Saito; Koichiro Kuwahara; Xianglu Rong; Ichiro Kishimoto; Masaki Harada; Yuichiro Adachi; Michio Nakanishi; Hideyuki Kinoshita; Masatsugu Horiuchi; Michael Murray; Kazuwa Nakao
ENDOCRINOLOGY, 150(8), 3759-3765, Aug. 2009, Refereed, Not invited
Lead

Endogenous cardiac natriuretic peptides protect the heart in a mouse model of dilated cardiomyopathy and sudden death
Shinji Yasuno; Satoru Usami; Koichiro Kuwahara; Michio Nakanishi; Yuji Arai; Hideyuki Kinoshita; Yasuaki Nakagawa; Masataka Fujiwara; Masao Murakami; Kenji Ueshima; Masaki Harada; Kazuwa Nakao
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 296(6), H1804-H1810, Jun. 2009, Refereed, Not invited
Lead

Endogenous cardiac natriuretic peptides protect the heart in a mouse model of dilated cardiomyopathy and sudden death
Shinji Yasuno; Satoru Usami; Koichiro Kuwahara; Michio Nakanishi; Yuji Arai; Hideyuki Kinoshita; Yasuaki Nakagawa; Masataka Fujiwara; Masao Murakami; Kenji Ueshima; Masaki Harada; Kazuwa Nakao
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 296(6), H1804-H1810, Jun. 2009, Refereed, Not invited
Lead

Fgf16 Is Required for Cardiomyocyte Proliferation in the Mouse Embryonic Heart
Yuhei Hotta; Sayaka Sasaki; Morichika Konishi; Hideyuki Kinoshita; Koichiro Kuwahara; Kazuwa Nakao; Nobuyuki Itoh
DEVELOPMENTAL DYNAMICS, 237(10), 2947-2954, Oct. 2008, Refereed, Not invited
Lead

Association of CT dinucleotide repeat polymorphism in the 5'-flanking region of the guanylyl cyclase (GC)-A gene with essential hypertension in the Japanese
Satoru Usami; Ichiro Kishimoto; Yoshihiko Saito; Masaki Harada; Koichiro Kuwahara; Yasuaki Nakagawa; Michio Nakanishi; Shinji Yasuno; Kenji Kangawa; Kazuwa Nakao
HYPERTENSION RESEARCH, 31(1), 89-96, Jan. 2008, Refereed, Not invited
Lead

A case report of right ventricular perforation 6 months after permanent pacemaker implantation
M. Nakanishi; M. Harada; K. Kuwahara; Y. Nakagawa; S. Usami; H. Kinoshita; M. Fujiwara; K. Nakao; N. Marui; K. Tambara; K. Nishina; M. Komeda; K. Ueshima
Respiration and circulation, 56(8), 861-865, 2008, Refereed, Not invited
Lead

Genetic disruption of angiotensin II type 1a receptor improves long-term survival of mice with chronic severe aortic regurgitation
Michio Nakanishi; Masaki Harada; Ichiro Kishimoto; Koichiro Kuwahara; Rika Kawakami; Yasuaki Nakagawa; Shinji Yasuno; Satoru Usami; Hideyuki Kinoshita; Yuichiro Adachi; Akiyoshi Fukamizu; Yoshihiko Saito; Kazuwa Nakao
CIRCULATION JOURNAL, 71(8), 1310-1316, Aug. 2007, Refereed, Not invited
Lead

Mitochondrial cardiomyopathy evaluated with cardiac magnetic resonance
Michio Nakanishi; Masaki Harada; Eiji Tadamura; Hirokazu Kotani; Rika Kawakami; Koichiro Kuwahara; Yasuaki Nakagawa; Satoru Usami; Hideyuki Kinoshita; Masataka Fujiwara; Kiminori Hosoda; Kenji Ueshima; Kazuwa Nakao
CIRCULATION, 116(2), E25-E26, Jul. 2007, Refereed, Not invited
Lead

Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity
Koichiro Kuwahara; Gordon C. Teg Pipes; John McAnally; James A. Richardson; Joseph A. Hill; Rhonda Bassel-Duby; Eric N. Olson
JOURNAL OF CLINICAL INVESTIGATION, 117(5), 1324-1334, May 2007, Refereed, Not invited
Lead

Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin
Tomasa Barrientos; Derk Frank; Koichiro Kuwahara; Svetlana Bezprozvannaya; G. C. Teg Pipes; Rhonda Bassel-Duby; James A. Richardson; Hugo A. Katus; Eric N. Olson; Norbert Frey
JOURNAL OF BIOLOGICAL CHEMISTRY, 282(11), 8393-8403, Mar. 2007, Refereed, Not invited
Lead

NRSF regulates the developmental and hypertrophic changes of HCN4 transcription in rat cardiac myocytes
Shinobu Kuratomi; Akiko Kuratomi; Koichiro Kuwahara; Takahiro M. Ishii; Kazuwa Nakao; Yoshihiko Saito; Makoto Takano
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 353(1), 67-73, Feb. 2007, Refereed, Not invited
Lead

TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling
Koichiro Kuwahara; Yanggan Wang; John McAnally; James A. Richardson; Rhonda Bassel-Duby; Joseph A. Hill; Eric N. Olson
JOURNAL OF CLINICAL INVESTIGATION, 116(12), 3114-3126, Dec. 2006, Refereed, Not invited
Lead

Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes
Yasuaki Nakagawa; Koichiro Kuwahara; Masaki Harada; Nobuki Takahashi; Shinji Yasuno; Yuichiro Adachi; Rika Kawakami; Michio Nakanishi; Keiji Tanimoto; Satoru Usami; Hideyuki Kinoshita; Yoshihiko Saito; Kazuwa Nakao
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 41(6), 1010-1022, Dec. 2006, Refereed, Not invited
Lead

Blockade of T-type calcium channel suppressed the arrhythmogenicity in dominant negative NRSF transgenic mice
Kinoshita Hideyuki; Kuwahara Kouichirou; Harada Masaki; Horie Minoru; Nakagawa Yasuaki; Nakanishi Michio; Usami Satoru; Fujiwara Masataka; Ueshima Kenji; Nakao Kazuwa
JOURNAL OF CARDIAC FAILURE, 12(8), S163, Oct. 2006, Refereed, Not invited
Lead

Blockade of angiotensin II type 1 receptor improves the arrhythmia morbidity in mice with left ventricular hypertrophy
CT Zhang; S Yasuno; K Kuwahara; DP Zankov; A Kobori; T Makiyama; M Horie
CIRCULATION JOURNAL, 70(3), 335-341, Mar. 2006, Refereed, Not invited
Lead

Class II histone deacetylases confer signal responsiveness to the ankyrin-repeat proteins ANKRA2 and RFXANK
TA McKinsey; K Kuwahara; S Bezprozvannaya; EN Olson
MOLECULAR BIOLOGY OF THE CELL, 17(1), 438-447, Jan. 2006, Refereed, Not invited
Lead

Pathophysiological significance of T-type Ca2+ channels: Transcriptional regulation of T-type Ca2+ channel - Regulation of CACNA1H by neuron-restrictive silencer factor
K Kuwahara; M Takano; K Nakao
JOURNAL OF PHARMACOLOGICAL SCIENCES, 99(3), 211-213, Nov. 2005, Refereed, Not invited
Lead

SOCS1/JAB likely mediates the protective effect of cardiotrophin-1 against lipopolysaccharide-induced left ventricular dysfunction in vivo
K Tanimoto; Y Saito; Hamanaka, I; K Kuwahara; M Harada; N Takahashi; R Kawakami; Y Nakagawa; M Nakanishi; Y Adachi; G Shirakami; K Fukuda; A Yoshimura; K Nakao
CIRCULATION JOURNAL, 69(11), 1412-1417, Nov. 2005, Refereed, Not invited
Lead

Role of natriuretic peptide receptor guanylyl cyclase-A in myocardial infarction evaluated using genetically engineered mice
M Nakanishi; Y Saito; Kishimoto, I; M Harada; K Kuwahara; N Takahashi; R Kawakami; Y Nakagawa; K Tanimoto; S Yasuno; S Usami; YH Li; Y Adachi; A Fukamizu; DL Garbers; K Nakao
HYPERTENSION, 46(2), 441-447, Aug. 2005, Refereed, Not invited
Lead

Muscle-specific signaling mechanism that links actin dynamics to serum response factor
K Kuwahara; T Barrientos; GCT Pipes; S Li; EN Olson
MOLECULAR AND CELLULAR BIOLOGY, 25(8), 3173-3181, Apr. 2005, Refereed, Not invited
Lead

Hypertrophic responses to cardiotrophin-1 are not mediated by STAT3, but via a MEK5-ERK5 pathway in cultured cardiomyocytes
N Takahashi; Y Saito; K Kuwahara; M Harada; K Tanimoto; Y Nakagawa; R Kawakami; M Nakanishi; S Yasuno; S Usami; A Yoshimura; K Nakao
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 38(1), 185-192, Jan. 2005, Refereed, Not invited
Lead

Overexpression of brain natriuretic peptide facilitates neutrophil infiltration and cardiac matrix metalloproteinase-9 expression after acute myocardial infarction
R Kawakami; Y Saito; Kishimoto, I; M Harada; K Kuwahara; N Takahashi; Y Nakagawa; M Nakanishi; K Tanimoto; S Usami; S Yasuno; H Kinoshita; H Chusho; N Tamura; Y Ogawa; K Nakao
CIRCULATION, 110(21), 3306-3312, Nov. 2004, Refereed, Not invited
Lead

Androgen contributes to gender-related cardiac hypertrophy and fibrosis in mice lacking the gene encoding guanylyl cyclase-A
YH Li; Kishimoto, I; Y Saito; M Harada; K Kuwahara; T Izumi; Hamanaka, I; N Takahashi; R Kawakami; K Tanimoto; Y Nakagawa; M Nakanishi; Y Adachi; DL Garbers; A Fukamizu; K Nakao
ENDOCRINOLOGY, 145(2), 951-958, Feb. 2004, Refereed, Not invited
Lead

Regulation of natriuretic peptide gene expression
K. Kuwahara; K. Nakao
Nippon rinsho. Japanese journal of clinical medicine, 62 Suppl 9, 28-30, 2004, Refereed, Not invited
Lead

NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function
K Kuwahara; Y Saito; M Takano; Y Arai; S Yasuno; Y Nakagawa; N Takahashi; Y Adachi; G Takemura; M Horie; Y Miyamoto; T Morisaki; S Kuratomi; A Noma; H Fujiwara; Y Yoshimasa; H Kinoshita; R Kawakami; Kishimoto, I; M Nakanishi; S Usami; Y Saito; M Harada; K Nakao
EMBO JOURNAL, 22(23), 6310-6321, Dec. 2003, Refereed, Not invited
Lead

Angiotensin II-induced ventricular hypertrophy and extracellular signal-regulated kinase activation are suppressed in mice overexpressing brain natriuretic peptide in circulation
N Takahashi; Y Saito; K Kuwahara; M Harada; Kishimoto, I; Y Ogawa; R Kawakami; Y Nakagawa; M Nakanishi; K Nakao
HYPERTENSION RESEARCH, 26(10), 847-853, Oct. 2003, Refereed, Not invited
Lead

Angiotensin II type 2 receptor deficiency exacerbates heart failure and reduces survival after acute myocardial infarction in mice
Y Adachi; Y Saito; Kishimoto, I; M Harada; K Kuwahara; N Takahashi; R Kawakami; M Nakanishi; Y Nakagawa; K Tanimoto; Y Saitoh; S Yasuno; S Usami; M Iwai; M Horiuchi; K Nakao
CIRCULATION, 107(19), 2406-2408, May 2003, Refereed, Not invited
Lead

Prognostic and clinical significance of newly acquired complete right bundle branch block in Japan airline pilots
M Taniguchi; H Nakano; K Kuwahara; Masuda, I; Y Okawa; H Miyazaki; H Okoshi; M Kaji; Y Noguchi; Asukata, I
INTERNAL MEDICINE, 42(1), 21-24, Jan. 2003, Refereed, Not invited
Lead

Guanylyl cyclase-A inhibits angiotensin II type 1A receptor-mediated cardiac remodeling, an endogenous protective mechanism in the heart
YH Li; Kishimoto, I; Y Saito; M Harada; K Kuwahara; T Izumi; N Takahashi; R Kawakami; K Tanimoto; Y Nakagawa; M Nakanishi; Y Adachi; DL Garbers; A Fukamizu; K Nakao
CIRCULATION, 106(13), 1722-1728, Sep. 2002, Refereed, Not invited
Lead

Fibronectin signaling stimulates BNP gene transcription by inhibiting neuron-restrictive silencer element-dependent repression
E Ogawa; Y Saito; K Kuwahara; M Harada; Y Miyamoto; Hamanaka, I; N Kajiyama; N Takahashi; T Izumi; R Kawakami; Kishimoto, I; Y Naruse; N Mori; K Nakao
CARDIOVASCULAR RESEARCH, 53(2), 451-459, Feb. 2002, Refereed, Not invited
Lead

Relationship between plasma level of cardiotrophin-1 and left ventricular mass index in patients with dilated cardiomyopathy
T Tsutamoto; A Wada; K Maeda; N Mabuchi; M Hayashi; T Tsutsui; M Ohnishi; M Fujii; T Matsumoto; T Yamamoto; XW Wang; S Asai; T Tsuji; H Tanaka; Y Saito; K Kuwahara; K Nakao; M Kinoshita
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 38(5), 1485-1490, Nov. 2001, Refereed, Not invited
Lead

Aldosterone induces angiotensin-converting-enzyme gene expression in cultured neonatal rat cardiocytes
E Harada; M Yoshimura; H Yasue; O Nakagawa; M Nakagawa; M Harada; Y Mizuno; M Nakayama; Y Shimasaki; T Ito; S Nakamura; K Kuwahara; Y Saito; K Nakao; H Ogawa
CIRCULATION, 104(2), 137-139, Jul. 2001, Refereed, Not invited
Lead

Blockade of the natriuretic peptide receptor guanylyl cyclase-A inhibits NF-kappa B activation and alleviates myocardial ischemia/reperfusion injury
T Izumi; Y Saito; Kishimoto, I; M Harada; K Kuwahara; Hamanaka, I; N Takahashi; R Kawakami; YH Li; G Takemura; H Fujiwara; DL Garbers; S Mochizuki; K Nakao
JOURNAL OF CLINICAL INVESTIGATION, 108(2), 203-213, Jul. 2001, Refereed, Not invited
Lead

Induction of JAB/SOCS-1/SSI-1 and CIS3/SOCS-3/SSI-3 is involved in gp130 resistance in cardiovascular system in rat treated with cardiotrophin-1 in vivo
Hamanaka, I; Y Saito; H Yasukawa; Kishimoto, I; K Kuwahara; Y Miyamoto; M Harada; E Ogawa; N Kajiyama; N Takahashi; T Izumi; R Kawakami; Masuda, I; A Yoshimura; K Nakao
CIRCULATION RESEARCH, 88(7), 727-732, Apr. 2001, Refereed, Not invited
Lead

The neuron-restrictive silencer element-neuron-restrictive silencer factor system regulates basal and endothelin 1-inducible atrial natriuretic peptide gene expression in ventricular myocytes
K Kuwahara; Y Saito; E Ogawa; N Takahashi; Y Nakagawa; Y Naruse; M Harada; Hamanaka, I; T Izumi; Y Miyamoto; Kishimoto, I; R Kawakami; M Nakanishi; N Mori; K Nakao
MOLECULAR AND CELLULAR BIOLOGY, 21(6), 2085-2097, Mar. 2001, Refereed, Not invited
Lead

The heart is a source of circulating cardiotrophin-1 in humans
S Asai; Y Saito; K Kuwahara; Y Mizuno; M Yoshimura; C Higashikubo; T Tsuji; Kishimoto, I; M Harada; Hamanaka, I; N Takahashi; H Yasue; K Nakao
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 279(2), 320-323, Dec. 2000, Refereed, Not invited
Lead

Replication protein A1 reduces transcription of the endothelial nitric oxide synthase gene containing a-786T -> C mutation associated with coronary spastic angina
Y Miyamoto; Y Saito; M Nakayama; Y Shimasaki; T Yoshimura; M Yoshimura; M Harada; N Kajiyama; Kishimoto, I; K Kuwahara; J Hino; E Ogawa; Hamanaka, I; S Kamitani; N Takahashi; R Kawakami; K Kangawa; H Yasue; K Nakao
HUMAN MOLECULAR GENETICS, 9(18), 2629-2637, Nov. 2000, Refereed, Not invited
Lead

Lack of association between T-786 -> C mutation in the 5 '-flanking region of the endothelial nitric oxide synthase gene and essential hypertension
N Kajiyama; Y Saito; Y Miyamoto; M Yoshimura; M Nakayama; M Harada; K Kuwahara; Kishimoto, I; H Yasue; K Nakao
HYPERTENSION RESEARCH, 23(6), 561-565, Nov. 2000, Refereed, Not invited
Lead

Cardiotrophin-1 phosphorylates Akt and BAD, and prolongs cell survival via a PI3K-dependent pathway in cardiac myocytes
K Kuwahara; Y Saito; Kishimoto, I; Y Miyamoto; M Harada; E Ogawa; Hamanaka, I; N Kajiyama; N Takahashi; T Izumi; R Kawakami; K Nakao
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 32(8), 1385-1394, Aug. 2000, Refereed, Not invited
Lead

Effects of cardiotrophin-1 on hemodynamics and endocrine function of the heart
Hamanaka, I; Y Saito; T Nishikimi; T Magaribuchi; S Kamitani; K Kuwahara; M Ishikawa; Y Miyamoto; M Harada; E Ogaea; N Kajiyama; N Takahashi; T Izumi; G Shirakami; K Mori; Y Inobe; Kishimoto, I; Masuda, I; K Fukuda; K Nakao
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 279(1), H388-H396, Jul. 2000, Refereed, Not invited
Lead

Outside-in signalling of fibronectin stimulates cardiomyocyte hypertrophy in cultured neonatal rat ventricular myocytes
E Ogawa; Y Saito; M Harada; S Kamitani; K Kuwahara; Y Miyamoto; M Ishikawa; Hamanaka, I; N Kajiyama; N Takahashi; O Nakagawa; Masuda, I; Kishimoto, I; K Nakao
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 32(5), 765-776, May 2000, Refereed, Not invited
Lead

Gq及びgp130刺激の心筋再構築における異なる役割
桑原 宏一郎; 斎藤 能彦; 石川 匡洋; 小川 惠美子; 原田 昌樹; 中尾 一和
日本臨床分子医学会記録, 36, 40-40, Mar. 2000, Refereed, Not invited
Lead

Effect of interleukin-1 beta on cardiac hypertrophy and production of natriuretic peptides in rat cardiocyte culture
E Harada; O Nakagawa; M Yoshimura; M Harada; M Nakagawa; Y Mizuno; Y Shimasaki; M Nakayama; H Yasue; K Kuwahara; Y Saito; K Nakao
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 31(11), 1997-2006, Nov. 1999, Refereed, Not invited
Lead

Involvement of cardiotrophin-1 in cardiac myocyte-nonmyocyte interactions during hypertrophy of rat cardiac myocytes in vitro
K Kuwahara; Y Saito; M Harada; M Ishikawa; E Ogawa; Y Miyamoto; Hamanaka, I; S Kamitani; N Kajiyama; N Takahashi; O Nakagawa; Masuda, I; K Nakao
CIRCULATION, 100(10), 1116-1124, Sep. 1999, Refereed, Not invited
Lead

The effects of the selective ROCK inhibitor, Y27632, on ET-1-induced hypertrophic response in neonatal rat cardiac myocytes - possible involvement of Rho ROCK pathway in cardiac muscle cell hypertrophy
K Kuwahara; Y Saito; O Nakagawa; Kishimoto, I; M Harada; E Ogawa; Y Miyamoto; Hamanaka, I; N Kajiyama; N Takahashi; T Izumi; R Kawakami; N Tamura; Y Ogawa; K Nakao
FEBS LETTERS, 452(3), 314-318, Jun. 1999, Refereed, Not invited
Lead

A heart-specific increase in cardiotrophin-1 gene expression precedes the establishment of ventricular hypertrophy in genetically hypertensive rats
M Ishikawa; Y Saito; Y Miyamoto; M Harada; K Kuwahara; E Ogawa; O Nakagawa; Hamanaka, I; N Kajiyama; N Takahashi; Masuda, I; T Hashimoto; O Sakai; T Hosoya; K Nakao
JOURNAL OF HYPERTENSION, 17(6), 807-816, Jun. 1999, Refereed, Not invited
Lead

フィブロネクチンのBNP遺伝子転写亢進機序の検討
小川 惠美子; 斎藤 能彦; 原田 昌樹; 桑原 宏一郎; 宮本 恵宏; 浜中 一郎; 梶山 登; 井野邊 義人; 高橋 伸基; 和泉 武彦
日本内分泌学会雑誌, 75(1), 111-111, Apr. 1999, Refereed, Not invited
Lead

Cardiotrophin-1によるgp130刺激とCISファミリーの発現 生体内,特に新血管系での検討
浜中 一郎; 斎藤 能彦; 岸本 一郎; 宮本 恵宏; 原田 昌樹; 桑原 宏一郎; 小川 惠美子; 梶山 登; 井野邊 義人; 和泉 武彦
日本内分泌学会雑誌, 75(1), 199-199, Apr. 1999, Refereed, Not invited
Lead

Restriction Landmark cDNA Scanning(RLCS)法を用いた,圧負荷肥大心と容量負荷肥大心に特異的なクローンの発見
和泉 武彦; 斉藤 能彦; 石川 匡洋; 錦見 俊雄; 岸本 一郎; 宮本 恵宏; 原田 昌樹; 桑原 宏一郎; 小川 惠美子; 浜中 一郎
日本内分泌学会雑誌, 75(1), 111-111, Apr. 1999, Refereed, Not invited
Lead

G蛋白共役型受容体刺激による活性化ERKは5'隣接領域の遠位部を介してANP遺伝子を誘導する
桑原 宏一郎; 斎藤 能彦; 岸本 一郎; 小川 佳宏; 田村 尚久; 原田 昌樹; 小川 惠美子; 宮本 恵宏; 浜中 一郎; 梶山 登
Japanese Circulation Journal, 63(Suppl.I), 169-169, Mar. 1999, Refereed, Not invited
Lead

アンジオテンシノーゲン遺伝子5'上流領域の遺伝子多型と本態性高血圧症との連関研究
梶山 登; 斎藤 能彦; 宮本 恵宏; 岸本 一郎; 原田 昌樹; 桑原 宏一郎; 小川 惠美子; 浜中 一郎; 井野邉 義人; 和泉 武彦
Japanese Circulation Journal, 63(Suppl.I), 215-215, Mar. 1999, Refereed, Not invited
Lead

ラット心臓を用いたCardiotrophin-1投与によるgp130刺激とCISファミリーの発現についての検討
浜中 一郎; 斎藤 能彦; 宮本 恵宏; 岸本 一郎; 原田 昌樹; 桑原 宏一郎; 小川 惠美子; 梶山 登; 高橋 伸基; 和泉 武彦
Japanese Circulation Journal, 63(Suppl.I), 248-248, Mar. 1999, Refereed, Not invited
Lead

容量負荷型肥大心において特異的に発現亢進している新規遺伝子の発見 Restriction Landmark cDNA Scanning(RLCS)法を用いて
和泉 武彦; 斎藤 能彦; 石川 匡洋; 桝田 出; 岸本 一郎; 宮本 恵宏; 井野邉 義人; 原田 昌樹; 桑原 宏一郎; 小川 惠美子
Japanese Circulation Journal, 63(Suppl.I), 251-251, Mar. 1999, Refereed, Not invited
Lead

フィブロネクチンのoutside-in signalingによるBNP遺伝子転写亢進機序の解明
小川 惠美子; 斎藤 能彦; 桑原 宏一郎; 原田 昌樹; 高橋 伸基; 岸本 一郎; 宮本 恵宏; 井野邉 義人; 浜中 一郎; 梶山 登
Japanese Circulation Journal, 63(Suppl.I), 252-252, Mar. 1999, Refereed, Not invited
Lead

エンドセリン-1による心筋細胞肥大反応におけるRho/p160rock経路の関与
桑原 宏一郎; 斎藤 能彦; 岸本 一郎; 小川 佳宏; 田村 尚久; 原田 昌樹; 小川 惠美子; 宮本 恵宏; 浜中 一郎; 梶山 登
Japanese Circulation Journal, 63(Suppl.I), 642-642, Mar. 1999, Refereed, Not invited
Lead

Endothelial nitric oxide synthase gene is positively associated with essential hypertension
Y Miyamoto; Y Saito; N Kajiyama; M Yoshimura; Y Shimasaki; M Nakayama; S Kamitani; M Harada; M Ishikawa; K Kuwahara; E Ogawa; Hamanaka, I; N Takahashi; T Kaneshige; H Teraoka; T Akamizu; N Azuma; Y Yoshimasa; T Yoshimasa; H Itoh; Masuda, I; H Yasue; K Nakao
HYPERTENSION, 32(1), 3-8, Jul. 1998, Refereed, Not invited
Lead

Interaction of myocytes and nonmyocytes is necessary for mechanical stretch to induce ANP/BNP production in cardiocyte culture
M Harada; Y Saito; K Kuwahara; E Ogawa; M Ishikawa; O Nakagawa; Y Miyamoto; S Kamitani; Hamanaka, I; N Kajiyama; N Takahashi; Masuda, I; H Itoh; K Nakao
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 31(SUPPL. 1), S357-S359, 1998, Refereed, Not invited
Lead

Endothelin-1 and cardiotrophin-1 induce brain natriuretic peptide gene expression by distinct transcriptional mechanisms
K Kuwahara; Y Saito; Y Ogawa; N Tamura; M Ishikawa; M Harada; E Ogawa; Y Miyamoto; Hamanaka, I; S Kamitani; N Kajiyama; N Takahashi; O Nakagawa; Masuda, I; K Nakao
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 31(SUPPL. 1), S354-S356, 1998, Refereed, Not invited
Lead

Significance of ventricular myocytes and nonmyocytes interaction during cardiocyte hypertrophy - Evidence for endothelin-1 as a paracrine hypertrophic factor from cardiac nonmyocytes
M Harada; H Itoh; O Nakagawa; Y Ogawa; Y Miyamoto; K Kuwahara; E Ogawa; T Igaki; J Yamashita; Masuda, I; T Yoshimasa; Tanaka, I; Y Saito; K Nakao
CIRCULATION, 96(10), 3737-3744, Nov. 1997, Refereed, Not invited
Lead

Role of cardiac nonmyocytes in cyclic mechanical stretch-induced myocyte hypertrophy
M Harada; Y Saito; O Nakagawa; Y Miyamoto; M Ishikawa; K Kuwahara; E Ogawa; M Nakayama; S Kamitani; Hamanaka, I; N Kajiyama; Masuda, I; H Itoh; Tanaka, I; K Nakao
HEART AND VESSELS, 198-200, 1997, Refereed, Not invited
Lead

cDNA cloning of rat cardiotrophin-1 (CT-1): Augmented expression of CT-1 gene in ventricle of genetically hypertensive rats
M Ishikawa; Y Saito; Y Miyamoto; K Kuwahara; E Ogawa; O Nakagawa; M Harada; Masuda, I; K Nakao
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 219(2), 377-381, Feb. 1996, Refereed, Not invited
Lead

Association of Mineralocorticoid Receptor Antagonist by Hospitalized Patients With Heart Failure With Preserved Ejection Fraction With Outcomes After Discharge
Hidenori Yaku; Takao Kato; Takeshi Morimoto; Yasutaka Inuzuka; Yodo Tamaki; Erika Yamamoto; Yusuke Yoshikawa; Neiko Ozasa; Koichiro Kuwahara; Takeshi Kimura
第23回日本心不全学会, Oct. 2019, Refereed, Not invited
Lead

Author's reply to “Anticoagulation strategy and management of patients with mechanical prosthetic heart valves during pregnancy”
Toshinori Komatsu; Hirohiko Motoki; Koichiro Kuwahara
Journal of Cardiology Cases, 20(2), 71, 01 Aug. 2019
Lead

BNP異常高値の原因がmacro-proBNP血症であった症例
中川 靖章; 錦見 俊雄; 酒井 宏; 大野 聖子; 木下 秀之; 稲住 英明; 森内 健史; 柳澤 洋; 桑原 宏一郎; 堀江 稔; 木村 剛
日本内分泌学会雑誌, 94(1), 347 - 347, Apr. 2018, Not invited
Lead

アドレノメデュリンは加齢や肥満に伴う高血圧を抑制する
趙 晃済; 桑原 宏一郎; 錦見 俊雄; 中川 靖章; 木下 秀之; 南 丈也; 稲住 英明; 森内 健史; 大矢 未来; 南野 直人; 木村 剛; 寒川 賢治; 中尾 一和
Anti-aging Science, 9(2), 100 - 100, Dec. 2017, Not invited
Lead

マクロproBNP血症の一例
中川 靖章; 錦見 俊雄; 酒井 宏; 大野 聖子; 木下 秀之; 稲住 英明; 森内 健史; 桑原 宏一郎; 堀江 稔; 木村 剛
日本内分泌学会雑誌, 93(4), 1392 - 1392, Dec. 2017, Not invited
Lead

2-Year Natural History of Lower Limbs in Patients With End-stage Renal Disease on Hemodialysis Due to Diabetic Nephropathy; From PREDICT Study
Tamon Kato; Yusuke Miyashita; Takashi Miura; Souitirou Ebisawa; Tatsuya Saigusa; Koichiro Kuwahara
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 70(18), B71 - B71, Oct. 2017, Not invited
Lead

Endothelium-derived C-type natriuretic peptide regulates blood pressure through the maintenance of endothelial function
K. Kuwahara; K. Nakao; T. Nishikimi; Y. Nakagawa; H. Kinoshita; T. Tokudome; N. Minamino; T. Kimura; K. Kangawa; K. Nakao
EUROPEAN JOURNAL OF HEART FAILURE, 19, 596 - 596, May 2017, Not invited
Lead

脂肪由来のアドレノメデュリンは加齢および肥満に伴う血圧上昇を抑制する
趙 晃済; 桑原 宏一郎; 南 丈也; 錦見 俊雄; 南野 直人; 中川 靖章; 木下 秀之; 稲住 英明; 森内 健史; 寒川 賢治; 中尾 一和; 木村 剛
日本臨床分子医学会学術総会プログラム・抄録集, 54回, 72 - 72, Apr. 2017, Not invited
Lead

脂肪細胞由来adrenomedullinは加齢および肥満に伴う血圧上昇を抑制する(Adipocyte-derived Adrenomedullin Suppresses Age- and Obesity-related Increase in Blood Pressure)
趙 晃済; 桑原 宏一郎; 南 丈也; 錦見 俊雄; 南野 直人; 中川 靖章; 木下 秀之; 稲住 英明; 森内 健史; 小池 薫; 寒川 賢治; 中尾 一和; 木村 剛
日本循環器学会学術集会抄録集, 81回, PJ - 322, Mar. 2017, Not invited
Lead

マクロproBNP血症の一例
中川靖章; 錦見俊雄; 錦見俊雄; 酒井宏; 大野聖子; 木下秀之; 稲住英明; 森内健史; 桑原宏一郎; 堀江稔; 木村剛
日本心血管内分泌代謝学会学術総会プログラム及び抄録集, 21st, 128, 2017, Not invited
http://jglobal.jst.go.jp/public/201802210782294861
Lead

Brain Natriuretic Peptide Counteracting the Renin-angiotensin-aldosterone System in Accelerated Malignant Hypertension
Hitoshi Nakagawa; Yuji Mizuno; Eisaku Harada; Yoshinobu Morikawa; Koichiro Kuwahara; Yoshihiko Saito; Hirofumi Yasue
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 352(5), 534 - 539, Nov. 2016, Not invited
Lead

Secretion of ProBNP is Regulated by Mir30-GALNTs Axis Dependent O-linked Glycosylation in the Pathological Myocardium
Yasuaki Nakagawa; Koichiro Kuwahara; Toshio Nishikimi; Hideyuki Kinoshita; Hideki Inazumi; Kenji Moriuchi; Takao Kato; Naoto Minamino; Kazuwa Nacho; Takeshi Kimura
CIRCULATION, 134, Nov. 2016, Not invited
Lead

Characteristics of Diagnostic Modalities and Corticosteroid Therapy in Cardiac Sarcoidosis
Yanagisawa H; Kinoshita H; Kato T; Saito N; Shizuta S; Nakagawa Y; Kuwahara K; Ono K; Kimura T
心不全学会 2016, Oct. 2016, Refereed, Not invited
Lead

肺動脈性肺高血圧症に対する肺移植術後急性期における左室および右室機能の評価
米田智也; 木下秀之; 木下秀之; 中島康弘; 中島康弘; 本山秀樹; 土屋恭子; 青山晃博; 陳豊史; 中川靖章; 柳澤洋; 牧山武; 静田聡; 桑原宏一郎; 木村剛; 伊達洋至; 一山智
日本心臓病学会学術集会(Web), 64th, ROMBUNNO.P‐366 (WEB ONLY) - 366, Sep. 2016, Not invited
http://jglobal.jst.go.jp/public/201602274122812145
Lead

MiR30-GALNT1/2 axis-mediated O-glycosylation plays a critical role in the processing and secretion of pro-brain natriuretic peptide by failing myocardium
Y. Nakagawa; T. Nishikimi; K. Kuwahara; S. Yasuno; H. Kinoshita; C. Yamada; H. Inazumi; T. Kato; Y. Kuwabara; K. Ueshima; K. Nakao; T. Kimura
EUROPEAN HEART JOURNAL, 37, 409 - 409, Aug. 2016, Not invited
Lead

膠原病関連肺高血圧症とCT所見
柳澤 洋; 木下 秀之; 吉藤 元; 半田 知宏; 藤井 隆夫; 牧山 武; 中川 靖章; 静田 聡; 桑原 宏一郎; 三森 経世; 木村 剛
呼吸と循環, 64(5), S46 - S47, May 2016, Not invited
Lead

MiR30-GALNT1/2 axis-mediated glycosylation at threonine 48 and 71 plays an essential role in the increased secretion of unprocessed pro-brain natriuretic peptide by failing hearts
K. Koichro Kuwahara; Y. Nakagawa; T. Nishikimi; K. Kangawa; N. Minamino; K. Nakao; T. Kimura
EUROPEAN JOURNAL OF HEART FAILURE, 18, 273 - 273, May 2016, Not invited
Lead

糖尿病性腎症におけるN型Ca₂₊チャネル阻害の腎保護効果
大野祥子; 横井秀基; 笠原正登; 森潔; 桑原宏一郎; 藤倉純二; 内藤雅喜; 桑原孝成; 菅原照; 柳田素子; 中尾一和; 向山政志
日本内分泌学会雑誌, 92(1), 212, 01 Apr. 2016, Not invited
http://jglobal.jst.go.jp/public/201602206101824521
Lead

Mir-30-GALNTs Axis-mediated Regulation in Glcosylation and Secretion of proBNP in the Failing Heart.
Nakagawa Y; Kuwahara K; Minamino N; Kato T; Kinoshita H; Yamada C; Inazumi H; Nakao K; Kimura T
第80回日本循環器学会学術集会, Mar. 2016, Refereed, Not invited
Lead

G蛋白サブユニットGαoの発現亢進が拡張型心筋症モデルマウスにおける心機能低下に関与する
稲住英明; 桑原宏一郎; 桑原佳宏; 中川靖章; 木下秀之; 森内健史; 錦見俊雄; 呉林なごみ; 柏原俊英; 山田充彦; 中尾一和; 木村剛
日本循環薬理学会口演要旨集, 26th, 2016
Lead

肺血管拡張薬中止理由の検討と病棟専従薬剤師の役割の考察
吉田優子; 木下秀之; 吉田詩織; 木下美津子; 中川靖章; 牧山武; 静田聡; 桑原宏一郎; 木村剛; 松原和夫
呼吸と循環, 63(8), S55-S56 - S56, 15 Aug. 2015, Not invited
http://jglobal.jst.go.jp/public/201502202267515583
Lead

肺高血圧症合併肺ランゲルハンス細胞組織球症に対する治療経過
柳澤洋; 木下秀之; 山田徹; 半田知宏; 中川靖章; 牧山武; 静田聡; 桑原宏一郎; 伊達洋至; 木村剛
呼吸と循環, 63(8), S57 - S57, 15 Aug. 2015, Not invited
http://jglobal.jst.go.jp/public/201502210376702647
Lead

糖尿病性腎症におけるN型Ca2+チャネル阻害の腎保護効果
大野 祥子; 横井 秀基; 笠原 正登; 森 潔; 桑原 宏一郎; 藤倉 純二; 内藤 雅喜; 桑原 孝成; 今牧 博貴; 石井 輝; 古賀 健一; 塩田 文彦; 沼田 朋大; 菅原 照; 森 泰生; 中尾 一和; 柳田 素子; 向山 政志
日本腎臓学会誌, 57(3), 569 - 569, Apr. 2015, Not invited
Lead

Ion channel remodeling in the progression of heart failure
Koichiro Kuwahara
The 79th Annual Scientific Meeting of The Japanese Circulation Society, Apr. 2015, Not invited
Lead

TRPC6 in pathological cardiac remodeling
Koichiro Kuwahara
The 88th Annual Meeting of The Japanese Pharmacological Society, Mar. 2015, Not invited
Lead

肺高血圧症を早期に発見できた間質性肺炎合併多発性筋炎の1症例
脊古裕太; 木下秀之; 柳沢洋; 藤井隆夫; 半田知宏; 山田千夏; 牧山武; 中川靖章; 静田聡; 桑原宏一郎; 尾野亘; 木村剛
日本循環器学会近畿地方会(Web), 119th, KINKI119,E14 (WEB ONLY), 2015, Not invited
http://jglobal.jst.go.jp/public/201502208166036259
Lead

ARVD様心形態を示した亜急性心筋炎の一例
牧山武; 川路徹真; 小笹寧子; 静田聡; 桑原宏一郎; 的場芳樹; 高橋衛; 木村剛
日本血管生物医学会学術集会プログラム・抄録集, 23rd, 190, 2015, Not invited
http://jglobal.jst.go.jp/public/201602213719114769
Lead

肺移植待機中の肺動脈性肺高血圧症患者における予後予測指標の検討
山上新太郎; 木下秀之; 本山秀樹; 土屋恭子; 青山晃博; 陳豊史; 辻村郎; 柳澤洋; 山田千夏; 牧山武; 中川靖章; 靜田聡; 桑原宏一郎; 尾野亘; 伊達洋至; 木村剛
日本循環器学会近畿地方会(Web), 120th, KINKI120,C39 (WEB ONLY), 2015, Not invited
http://jglobal.jst.go.jp/public/201602228116050312
Lead

非アルコール性脂肪肝炎に合併したと考えられる門脈圧亢進症性肺動脈性肺高血圧症の1症例
辰島正二郎; 木下秀之; 柳沢洋; 川治徹真; 山田千夏; 牧山武; 中川靖章; 静田聡; 桑原宏一郎; 尾野亘; 木村剛
日本循環器学会近畿地方会(Web), 120th, KINKI120,C36 (WEB ONLY), 2015, Not invited
http://jglobal.jst.go.jp/public/201602245485463134
Lead

血液透析施行中の末期腎不全に合併した肺高血圧症に対し肺血管拡張薬を投与した1症例
家村知樹; 山田千夏; 木下秀之; 辰島正二郎; 小笹寧子; 渡部宏俊; 牧山武; 中川靖章; 静田聡; 桑原宏一郎; 尾野亘; 木村剛
日本循環器学会近畿地方会(Web), 120th, KINKI120,F23 (WEB ONLY), 2015, Not invited
http://jglobal.jst.go.jp/public/201602296482620208
Lead

気腫合併肺線維症に合併した高度肺高血圧に対し肺血管拡張療法を行った1症例
岡林真梨恵; 木下秀之; 相澤卓範; 半田知宏; 室繁郎; 山田千夏; 牧山武; 中川靖章; 静田聡; 桑原宏一郎; 尾野亘; 木村剛
日本循環器学会近畿地方会(Web), 120th, KINKI120,C37 (WEB ONLY), 2015, Not invited
http://jglobal.jst.go.jp/public/201602296682654921
Lead

Role of O-glycosylation in N-terminal Region of Human proBNP in proBNP Processing
Yasuaki Nakagawa; Toshio Nishikimi; Koichiro Kuwahara; Shinji Yasuno; Hideyuki Kinoshita; Yoshihiro Kuwabara; Chinatsu Yamada; Kenji Ueshima; Takeshi Kumura; Kazuwa Nakao
JOURNAL OF CARDIAC FAILURE, 20(10), S151 - S151, Oct. 2014, Not invited
Lead

Pivotal Involvement of Renin-angiotensin System in Generating Arrhythmogenic Substrates in Mice with Chronic Heart Failure and Lethal Arrhythmias
Chinatsu Yamada; Koichiro Kuwahara; Hideyuki Kinoshita; Yasuaki Nakagawa; Toshio Nishikimi; Kazuwa Nakao; Takeshi Kimura
JOURNAL OF CARDIAC FAILURE, 20(10), S185 - S185, Oct. 2014, Not invited
Lead

肺動脈性肺高血圧症患者に対する最新の治療を考える
木下秀之; 柳澤洋; 山田千夏; 中川靖章; 牧山武; 静田聡; 桑原宏一郎; 木村剛
日本心臓病学会学術集会抄録(CD-ROM), 62nd, ROMBUNNO.JS4-3, 02 Sep. 2014, Not invited
http://jglobal.jst.go.jp/public/201502293528713846
Lead

Critical involvement of renin-angiotensin system for developing arrhythmogenic remodeling in mice with chronic heart failure and lethal arrhythmias
C. Yamada; K. Kuwahara; Y. Kuwabara; H. Kinoshita; Y. Nakagawa; T. Nihikimi; K. Nakao; T. Kimura
EUROPEAN HEART JOURNAL, 35, 328 - 329, Sep. 2014, Not invited
Lead

第3回 重症肺高血圧症カンファレンス 症例提示‐3 肺野に異常陰影の出現を認めた特発性肺動脈性肺高血圧症の1症例
木下秀之; 柳澤洋; 西川隆介; 中川靖章; 牧山武; 桑原宏一郎; 木村剛
心臓, 46(6), 807 - 811, 15 Jun. 2014, Not invited
Lead

糖尿病性腎症におけるN型Ca2+チャネル阻害の意義
大野 祥子; 横井 秀基; 笠原 正登; 森 潔; 桑原 宏一郎; 藤倉 純二; 内藤 雅喜; 桑原 孝成; 今牧 博貴; 石井 輝; 古賀 健一; 沼田 朋大; 菅原 照; 森 泰生; 柳田 素子; 中尾 一和; 向山 政志
糖尿病, 57(Suppl.1), S - 266, Apr. 2014, Not invited
Lead

血管肉腫による収縮性心膜炎様の病態をきたした1症例
小椋淳平; 木下秀之; 川治徹真; 桑原佳宏; 中川靖章; 牧山武; 桑原宏一郎; 木村剛
日本循環器学会近畿地方会(Web), 117th, KINKI117,H17 (WEB ONLY), 2014, Not invited
http://jglobal.jst.go.jp/public/201402251240490565
Lead

先天性右肺動脈欠損を伴う肺高血圧症に僧帽弁逆流症・心房細動を合併し,集学的治療を施行した1例
笹智樹; 桑原佳宏; 田崎淳一; 木下秀之; 牧山武; 中川靖章; 静田聡; 桑原宏一郎; 尾野亘; 木村剛
日本循環器学会近畿地方会(Web), 117th, KINKI117,D09 (WEB ONLY), 2014, Not invited
http://jglobal.jst.go.jp/public/201402278409536603
Lead

間質性肺炎を合併した強皮症関連肺動脈性高血圧症に対しPGI2持続静注療法を施行した1症例
柳澤洋; 木下秀之; 西川隆介; 桑原佳宏; 中川靖章; 牧山武; 桑原宏一郎; 木村剛
日本循環器学会近畿地方会(Web), 117th, KINKI117,G39 (WEB ONLY), 2014, Not invited
http://jglobal.jst.go.jp/public/201402295619301031
Lead

サルコイドーシスに合併した肺高血圧症の一例
沼尚吾; 木下秀之; 辰島正二郎; 樋上裕起; 牧山武; 桑原宏一郎; 木村剛
日本循環器学会近畿地方会(Web), 117th, KINKI117,G21 (WEB ONLY), 2014, Not invited
http://jglobal.jst.go.jp/public/201402296994335012
Lead

膠原病関連肺高血圧症に対する早期発見による肺血管拡張薬治療効果の検討
柳澤洋; 木下秀之; 山田千夏; 桑原佳宏; 中川靖章; 牧山武; 静田聡; 尾野亘; 塩井哲雄; 桑原宏一郎; 木村剛
日本循環器学会近畿地方会(Web), 118th, KINKI118,A16 (WEB ONLY), 2014, Not invited
http://jglobal.jst.go.jp/public/201502251055501264
Lead

Pivotal contribution of renin-angiotensin system to promoting arrhythmogenic remodeling in mice model of chronic heart failure with lethal arrhythmias
Koichiro Kuwahara
Gordon Conference: Angiotensin The Renin-Angiotensin System Beyond Angiotensin II, 2014, Not invited
Lead

O-glycosylated Pro-B-type Natriuretic Peptide is Cleaved Intracellularly by Furin in Ventricular and Atrial Myocytes: Importance of the Distance between the O-glycosylation and Cleavage Sites
Toshio Nishikimi; Yasuaki Nakagawa; Naoto Minamino; Masashi Ikeda; Toshihiko Ishimitsu; Chinatsu Yamada; Kazuhiro Nakao; Yoshihiro Kuwabara; Hideyuki Kinoshita; Koichiro Kuwahara; Kenji Kangawa; Kazuwa Nakao
CIRCULATION, 128(22), Nov. 2013, Not invited
Lead

Evaluation of proBNP in End-stage Renal Disease Patients on Hemodialysis
Yasuaki Nakagawa; Toshio Nishikimi; Koichiro Kuwahara; Shinji Yasuno; Hideyuki Kinoshita; Yoshihiro Kuwabara; Kazuhiro Nakao; Chinatsu Yamada; Kenji Ueshima; Kazuwa Nakao
JOURNAL OF CARDIAC FAILURE, 19(10), S168 - S168, Oct. 2013, Not invited
Lead

N型Caチャネルノックアウトマウスを用いた糖尿病性腎症におけるN型カルシウムチャネルの意義
大野 祥子; 横井 秀基; 笠原 正登; 森 潔; 桑原 宏一郎; 藤倉 純二; 内藤 雅喜; 桑原 孝成; 今牧 博貴; 古賀 健一; 沼田 朋大; 菅原 照; 森 泰生; 中尾 一和; 向山 政志
日本高血圧学会総会プログラム・抄録集, 36回, 282 - 282, Oct. 2013, Not invited
Lead

SRF転写活性化因子MRTF-Aの脂肪組織形成における意義
趙 晃済; 南 丈也; 桑原 宏一郎; 日下部 徹; 野口 倫生; 酒井 建; 錦見 俊雄; 中川 靖章; 木下 秀之; 桑原 佳宏; 山田 千夏; 柴田 純子; 山田 優子; 中尾 一泰; 上嶋 健治; 保野 慎治; 細田 公則; 小池 薫; 中尾 一和
肥満研究, 19(Suppl.), 177 - 177, Sep. 2013, Not invited
Lead

Effect of hemodyalysis on precursor proBNP and glycosylated NT-proBNP in end-stage renal disease patients
Y. Nakagawa; T. Nishikimi; K. Kuwahara; S. Yasuno; H. Kinoshita; Y. Kuwabara; C. Yamada; K. Nakao; K. Ueshima; K. Nakao
EUROPEAN HEART JOURNAL, 34, 938 - 938, Aug. 2013, Not invited
Lead

糖尿病性腎症におけるN型カルシウムチャネルの意義
大野 祥子; 向山 政志; 横井 秀基; 笠原 正登; 森 潔; 藤倉 純二; 桑原 宏一郎; 内藤 雅喜; 桑原 孝成; 今牧 博貴; 石井 輝; 古賀 健一; 沼田 朋大; 菅原 照; 森 泰生; 中尾 一和
日本腎臓学会誌, 55(3), 349 - 349, Apr. 2013, Not invited
Lead

Isoproterenol-induced spontaneous action potentials in the cardiac myocytes of transgenic mouse overexpressing HCN2
Kensuke Oshita; Sachiyo Igata; Yoshihiro Kuwabara; Koichiro Kuwahara; Kazuo Ushijima; Makoto Takano
JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, S134 - S134, 2013, Not invited
Lead

Hickmanカテーテル関連血流感染症に対し抗生剤ロック療法を行った1症例の検討
廣田圭昭; 木下秀之; 山田千夏; 中尾一泰; 南丈也; 桑原佳宏; 保野慎治; 宇佐美覚; 中川靖章; 牧山武; 錦見俊雄; 上嶋健治; 桑原宏一郎; 木村剛
日本循環器学会近畿地方会(Web), 116th, KINKI116,C50 (WEB ONLY), 2013, Not invited
http://jglobal.jst.go.jp/public/201402210957734371
Lead

肺ランゲルハンス細胞組織球症に合併した肺高血圧症に対しエポプロステノールを使用した1症例
波多腰桃子; 木下秀之; 西川隆介; 山田千夏; 中尾一泰; 南丈也; 桑原佳宏; 保野慎治; 宇佐美覚; 中川靖章; 牧山武; 錦見俊雄; 上嶋健治; 桑原宏一郎; 木村剛
日本循環器学会近畿地方会(Web), 116th, KINKI116,E07 (WEB ONLY), 2013, Not invited
http://jglobal.jst.go.jp/public/201402296805351550
Lead

ナトリウム利尿ペプチド発現制御機構解明による心血管病治療標的の同定
桑原 宏一郎
第17回日本心血管内分泌代謝学会総会, 2013, Not invited
Lead

Myocardin-related transcription factor-A plays a pivotal role in vascular remodeling
Koichiro Kuwahara
第45回 日本動脈硬化学会, 2013, Not invited
Lead

心不全・突然死モデルマウスを用いた心不全の病態解明と新規治療標的の同定
桑原 宏一郎
第９０回日本生理学会大会, 2013, Not invited
Lead

Multi-organ communication in sudden arrhythmic death accompanied with heart failure
Koichiro Kuwahara
The77th Annual Scientific Meeting of The Japanese Circulation, 2013, Not invited
Lead

Elucidation of molecular mechanisms underlying the regulation and action of cardiovascular hormones to find novel therapeutic targets for cardiovascular diseases
Koichiro Kuwahara
The77th Annual Scientific Meeting of The Japanese Circulation, 2013, Not invited
Lead

Direct Renin Inhibitor Strongly Prevents Ventricular Arrhythmogenic Remodeling and Sudden Cardiac Death in Mice with Dilated Cardiomyopathy
Chinatsu Yamada; Koichiro Kuwahara; Hidevuki Kinoshita; Yoshihiro Kuwabara; Takeya Minami; Kazuhiro Nakao; Shinji Yasuno; Yasuaki Nakagawa; Kenji Ueshima; Kazuwa Nakao
CIRCULATION, 126(21), Nov. 2012, Not invited
Lead

我が国の内科領域のトランスレーショナルリサーチとEBM トランスレーショナルリサーチ 4)内分泌代謝内科学領域のトランスレーショナルリサーチ
HOSODA KIMINORI; YASODA AKIHIRO; EBIHARA KEN; KUWAHARA KOICHIRO; MUKOYAMA MASASHI; NAKAO KAZUWA
日本内科学会雑誌, 101(9), 2552 - 2562, 10 Sep. 2012, Not invited
Lead

Direct renin inhibitor prevents ventricular remodeling and sudden arrhythmic death in mice with dilated cardiomyopathy
C. Yamada; K. Kuwahara; T. Minami; Y. Kuwabara; K. Nakao; H. Kinoshita; S. Usami; Y. Nakagawa; T. Nishikimi; K. Nakao
EUROPEAN HEART JOURNAL, 33, 1100 - 1100, Aug. 2012, Not invited
Lead

禁酒と減量により血糖コントロールが改善した肝硬変合併糖尿病の一例
野村 英生; 清水 浩一郎; 桑原 宏一郎; 阿部 恵; 森 栄作; 日下部 徹; 藤倉 純二; 孫 徹; 海老原 健; 細田 公則; 中尾 一和
日本内分泌学会雑誌, 88(1), 326 - 326, Apr. 2012, Not invited
Lead

トランスレーショナルリサーチ 4)内分泌代謝内科学領域のトランスレーショナルリサーチ
HOSODA KIMINORI; YASODA AKIHIRO; EBIHARA KEN; KUWABARA KOICHIRO; MUKOYAMA MASASHI; NAKAO KAZUWA
日本内科学会雑誌, 101, 115, 20 Feb. 2012, Not invited
Lead

Calcium channels as novel therapeutic targets in heart failure
Koichiro Kuwahara; Hideyuki Kinoshita; Kazuwa Nakao
JOURNAL OF PHARMACOLOGICAL SCIENCES, 118, 14P - 14P, 2012, Not invited
Lead

Molecular mechanisms underlying cardioprotective effects of natriuretic peptide
Koichiro Kuwahara
The 7th Oulu Symposium, 2012, Not invited
Lead

Neurohumoral regulation in the process of pathological cardiac remodeling
Koichiro Kuwahara
第29回国際心臓研究学会(ISHR)日本部会, 2012, Not invited
Lead

Translational Research of Natriuretic Peptide in Cardiovascular Disease
Koichiro Kuwahara
The76th Annual Scientific Meeting of The Japanese CirculationSociety, 2012, Not invited
Lead

Induction of Myocardin-Related Transcription Factor-A Contributes to the Phenotypic Alteration of Vascular Smooth Muscle Cells and Plays a Pivotal Role in Vascular Remodeling
Takeya Minami; Koichiro Kuwahara; Yasuaki Nakagawa; Hideyuki Kinoshita; Kazuhiro Nakao; Yoshihiro Kuwabara; Yuko Yamada; Chinatsu Yamada; Junko Shibata; Satoru Usami; Toshio Nishikimi; Kazuwa Nakao
CIRCULATION, 124(21), Nov. 2011, Not invited
Lead

Cardiac-Specific Overexpression of High Mobility Group Box 1 (HMGB1) Attenuates Cardiac Dysfunction Induced By Pressure Overload
Akira Funayama; Tetsuro Shishido; Shunsuke Netsu; Mitsunori Ishino; Yoichiro Otaki; Shintaro Honda; Hiromasa Hasegawa; Shinpei Kadowaki; Taro Narumi; Satoshi Nishiyama; Hiroki Takahashi; Takanori Arimoto; Takehiko Miyashita; Takuya Miyamoto; Tetsu Watanabe; Chang-Hoon Woo; Jun-ichi Abe; Koichiro Kuwahara; Kazuwa Nakao; Yasuchika Takeishi; Isao Kubota
CIRCULATION, 124(21), Nov. 2011, Not invited
Lead

心筋ミトゴンドリア機能を調節する転写調節ネットワーク(4.代謝制御からみた心筋障害・心不全の病態解明-基礎から臨床へ,<特集>第75回日本循環器学会学術集会)
中川 靖章; 桑原 宏一郎; 中尾 一和
循環器専門医 : 日本循環器学会専門医誌, 19(2), 243 - 248, 25 Sep. 2011
Lead

A Case of Severe Chronic Heart Failure Successfully Controlled with Long Term Administration of Tolvaptan; a V(2)-specific Vasopressin Receptor Antagonists
Yuna Yamagami; Hideyuki Kinoshita; Koichiro Kuwahara; Yoshihiro Kuwabara; Shinji Yasuno; Satoru Usami; Yasuaki Nakagawa; Toshio Nishikimi; Kenji Ueshima; Kazuwa Nakao
JOURNAL OF CARDIAC FAILURE, 17(9), S166 - S166, Sep. 2011, Not invited
Lead

HCN Channel Inhibition Prevents Sudden Arrhythmic Death in a Mouse Model of Dilated Cardiomyopathy Independently of Heart Rate Reduction
Yoshihiro Kuwabara; Koichiro Kuwahara; Makoto Takano; Hideyuki Kinoshita; Yasuaki Nakagawa; Satoru Usami; Takeya Minami; Toshio Nishikimi; Kenji Ueshima; Kazuwa Nakao
JOURNAL OF CARDIAC FAILURE, 17(9), S153 - S153, Sep. 2011, Not invited
Lead

HCN channel inhibition with ivabradine prevents sudden arrhythmic death in a mouse model of dilated cardiomyopathy
Y. Kuwabara; K. Kuwahara; H. Kinoshita; M. Takano; Y. Nakagawa; S. Usami; S. Yasuno; T. Nishikimi; K. Ueshima; K. Nakao
EUROPEAN HEART JOURNAL, 32, 288 - 289, Aug. 2011, Not invited
Lead

Blockade of TRPC6/3 is a novel therapeutic approach for preventing pathological cardiac hypertrophy
H. Kinoshita; K. Kuwahara; M. Nishida; H. Kurose; S. Kiyonaka; Y. Mori; Y. Kuwabara; Y. Nakagawa; K. Ueshima; K. Nakao
EUROPEAN HEART JOURNAL, 32, 1093 - 1094, Aug. 2011, Not invited
Lead

Analysis of circulating glycosylated N-terminal-proBNP and nonglycosylated N-terminal proBNP in patients with heart failure (HF) and chronic renal failure (CRF) on hemodialysis
T. Nishikimi; M. Ikeda; Y. Takeda; T. Ishimitsu; N. Minamino; K. Kuwahara; Y. Nakagawa; H. Kinoshita; K. Nakao
EUROPEAN HEART JOURNAL, 32, 910 - 910, Aug. 2011, Not invited
Lead

BNP遺伝子発現調節領域におけるserum response factor応答領域の新たなる同定とその心筋細胞肥大反応における意義
桑原 宏一郎
第15回日本心血管内分泌学会, 2011, Not invited
Lead

心房性および脳性ナトリウム利尿ペプチドの発現制御及び心不全発症における役割
桑原 宏一郎
第84回日本内分泌学会学術総会, 2011, Not invited
Lead

T-type Ca2+channel blockade improved cardiac autonomic nervous system imbalance and reduced sudden death in mice model of chronic heart failure
H. Kinoshita; K. Kuwahara; T. Makoto; Y. Kuwabara; M. Fujiwara; S. Yasuno; S. Usami; Y. Nakagawa; K. Ueshima; K. Nakao
EUROPEAN HEART JOURNAL, 31, 419 - 419, Sep. 2010, Not invited
Lead

Inhibition of TRPC6 Channel Activity Contributes to the Antihypertrophic Effects of Natriuretic Peptides-Guanylyl Cyclase-A Signaling in the Heart
Hideyuki Kinoshita; Koichiro Kuwahara; Motohiro Nishida; Zhong Jian; Xianglu Rong; Shigeki Kiyonaka; Yoshihiro Kuwabara; Hitoshi Kurose; Ryuji Inoue; Yasuo Mori; Yuhao Li; Yasuaki Nakagawa; Satoru Usami; Masataka Fujiwara; Yuko Yamada; Takeya Minami; Kenji Ueshima; Kazuwa Nakao
CIRCULATION RESEARCH, 106(12), 1849 - U153, Jun. 2010, Not invited
Lead

Inhibition of TRPC6 Channel Activity Contributes to the Antihypertrophic Effects of Natriuretic Peptides-Guanylyl Cyclase-A Signaling in the Heart
Hideyuki Kinoshita; Koichiro Kuwahara; Motohiro Nishida; Zhong Jian; Xianglu Rong; Shigeki Kiyonaka; Yoshihiro Kuwabara; Hitoshi Kurose; Ryuji Inoue; Yasuo Mori; Yuhao Li; Yasuaki Nakagawa; Satoru Usami; Masataka Fujiwara; Yuko Yamada; Takeya Minami; Kenji Ueshima; Kazuwa Nakao
CIRCULATION RESEARCH, 106(12), 1849 - U153, Jun. 2010, Not invited
Lead

Effusive constrictive periarditis possibly caused by infection in a patient with hyperthyroidism
Chinatsu Yamada; Koichiro Kuwahara; Masako Miura; Yuko Yamada; Takeya Minami; Yoshihiro Kuwabara; Masataka Fujiwara; Hideyuki Kinoshita; Satoru Usami; Yasuaki Nakagawa; Kazuma Nakao
ENDOCRINE JOURNAL, 57, S558 - S558, Mar. 2010, Not invited
Lead

N-type Ca2+ channel blockade prevents sudden death in mice with heart failure
Yuko Yamada; Koichiro Kuwahara; Hideyuki Kinoshita; Yoshihiro Kuwabara; Yasuaki Nakagawa; Masaki Harada; Shinji Yasuno; Takeya Minami; Satoshi Usami; Masataka Fujiwara; Masao Murakami; Kenji Ueshima; Kazuwa Nakao
ENDOCRINE JOURNAL, 57, S566 - S566, Mar. 2010, Not invited
Lead

Myocardin-related transcription factor-A, a Rho-dependent co-factor of serum response factor, is a common mediator for mechanical stretch- and neurohumoral stimulation-induced increase in BNP gene transcription
Koichiro Kuwahara; Yoshihiro Kuwabara; Hideyuki Kinoshita; Kazuwa Nakao
ENDOCRINE JOURNAL, 57, S549 - S550, Mar. 2010, Not invited
Lead

Functional inhibition of p300 affects the mitochondrial function and cell survival in the post-natal heart in mice
Yasuaki Nakagawa; Koichiro Kuwahara; Genzo Takemura; Masaharu Akao; Yuji Arai; Masaki Harada; Satoru Usami; Shinji Yasuno; Hideyuki Kinoshita; Masataka Fujiwara; Yoshihiro Kuwabara; Takeya Minami; Chinatsu Yamada; Kenji Ueshima; Kazuwa Nakao
ENDOCRINE JOURNAL, 57, S566 - S567, Mar. 2010, Not invited
Lead

CT dinucleotide repeat polymorphism in the promoter region of Guanylyl Cyclase (GC)-A gene is associated with essential hypertension in the Japanese
Satoru Usami; Ichiro Kishimoto; Koichiro Kuwahara; Yasuaki Nakagawa; Shinji Yasuno; Hideyuki Kinoshita; Kazuwa Nakao
ENDOCRINE JOURNAL, 57, S565 - S565, Mar. 2010, Not invited
Lead

Search for novel therapeutic targets in heart failure
Koichiro Kuwahara; Kazuwa Nakao
JOURNAL OF PHARMACOLOGICAL SCIENCES, 112, 18P - 18P, 2010, Not invited
Lead

NRSF maintains normal cardiac structure and function
Koichiro Kuwahara
20th World Congress of the International Society of Heart Research, 2010, Not invited
Lead

Angiotensin receptors signaling in cardiac remodeling
Koichiro Kuwahara
14th International Congress of Endocrinology ICE2010, 2010, Not invited
Lead

Rho依存性転写共役因子myocardin-related transcription factor-Aの心肥大シグナルにおける役割
桑原 宏一郎
第33回 日本高血圧学会総会, 2010, Not invited
Lead

Rho and actin dynamics-dependent nuclear translocation of MRTF-A is a common molecular mechanisms underlying both mechanical stretch- and neurohumoral stimulation-induced cardiac hypertrophy
Koichiro Kuwahara
14th Annual Scientific Session of the Society of Cardiovacular Endocrinology and Metabolism, 2010, Not invited
Lead

心房性および脳性ナトリウム利尿ペプチドの遺伝子発現調節、作用機序と臨床的意義の解明
桑原 宏一郎
第83回日本内分泌学会学術総会, 2010, Not invited
Lead

心不全に対する新規治療標的の探索
桑原 宏一郎
第83回日本薬理学会年会, 2010, Not invited
Lead

Myocardin-related transcription factor-A is a common mediator of mechanical stretch- and neurohumoral stimulation-induced hypertrophic response
Koichiro Kuwahara
The74th Annual Scientific Meeting of The Japanese Circulation, 2010, Not invited
Lead

P300 Determines Tolerance to Ischemia in the Heart by Regulating Mitochondrial Gene Expression and Function
Yasuaki Nakagawa; Koichiro Kuwahara; Masaki Harada; Satoru Usami; Shinji Yasuno; Hideyuki Kinoshita; Masataka Fujiwara; Yoshihiro Kuwabara; Yuko Yamada; Takeya Minami; Kenji Ueshima; Kazuwa Nakao
CIRCULATION RESEARCH, 105(7), E21 - E21, Sep. 2009, Not invited
Lead

OE-172 A Novel NRSF-binding Partner Zfp90 Negatively Regulates the Repression Activity of NRSF, a Critical Regulator of Cardiac Fetal Gene Program(OE29,Molecular Biology Myocardium (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
Kuwahara Koichiro; Murakami Masao; Harada Masaki; Nakagawa Yasuaki; Usami Satoru; Kinoshita Hideyuki; Yasuno Shinji; Fujiwara Masataka; Kuwabara Yoshihiro; Ueshima Kenji; Nakao Kazuwa
Circulation journal : official journal of the Japanese Circulation Society, 73, 216 - 216, 01 Mar. 2009
Lead

PE-165 An Important Role of p300 on Mitochondrial Gene Expression and Function and Tolerance to Ischemia in the Heart(PE028,Heart Failure, Basic (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
Nakagawa Yasuaki; Kuwahara Koichiro; Akao Masaharu; Katoh Masashi; Takemura Genzou; Harada Masaki; Usami Satoru; Yasuno Shinji; Kinoshita Hideyuki; Fujiwara Masataka; Kuwabara Yoshihiro; Ueshima Kenji; Nakao Kazuwa
Circulation journal : official journal of the Japanese Circulation Society, 73, 440 - 440, 01 Mar. 2009
Lead

DPE-007 Protein Kinase G-mediated Inhibition of TRPC6 Channel Activity Participates in Anti-hypertrophic Effect of Cardiac Natriuretic Peptides(DPE02,Heart Failure, Basic (M),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
Kinoshita Hideyuki; Kuwahara Koichiro; Inoue Ryuji; Nishida Motohiro; Kurose Hitoshi; Kiyonaka Shigeki; Mori Yasuo; Li Yuhao; Rong Xiang Lu; Murakami Masao; Nakagawa Yasuaki; Yasuno Shinji; Usami Satoru; Fujiwara Masataka; Kuwabara Yoshihiro; Yamada Yuko; Minami Takeshi; Harada Masaki; Ueshima Kenji; Nakao Kazuwa
Circulation journal : official journal of the Japanese Circulation Society, 73, 357 - 357, 01 Mar. 2009
Lead

FRS-094 MRTF-A, a Rho-dependent Co-activaotr of SRF, Mediates Mechanical Stress-induced Hypertrophic Gene Reprogramming(FRS19,Genetic Abnormalities in Cardiac Hypertrophy and Cardiomyopathy (M),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
Kuwahara Koichiro; Nakao Kazuwa; Olson Eric
Circulation journal : official journal of the Japanese Circulation Society, 73, 162 - 162, 01 Mar. 2009
Lead

DIRECTLY REGULATES THE TRANSCRIPTION OF HCN4, CARDIAC PACEMAKER CHANNEL
Makoto Takano; Kuniko Shimazaki; Shin-ichi Muramatsu; Koichiro Kuwahara
JOURNAL OF PHYSIOLOGICAL SCIENCES, 59, 170 - 170, 2009, Not invited
Lead

Transcriptional Pathways Regulating Cardiac Remodeling
Koichiro Kuwahara
2009MRC international Symposia, 2009, Not invited
Lead

心房性および脳性ナトリウム利尿ペプチドの遺伝子発現調節、作用機序と臨床的意義の解明
桑原 宏一郎
第13回日本心血管内分泌代謝学会総会, 2009, Not invited
Lead

心臓内分泌代謝機能における転写共役因子の役割
桑原 宏一郎
第82回日本内分泌学会学術総会, 2009, Not invited
Lead

MRTF-A, a Rho-dependent Co-activaotr of SRF, Mediates
Koichiro Kuwahara
The73rd Annual Scientific Meeting of The Japanese Circulation, 2009, Not invited
Lead

A Novel NRSF-binding Partner Zfp90 Negatively Regulates
Koichiro Kuwahara
The73rd Annual Scientific Meeting of The Japanese Circulation, 2009, Not invited
Lead

NRSF regulates the developmental and hypertrophic changes of HCN4 transcription in rat cardiac myocytes
倉富 忍; 倉富 暁子; 桑原 宏一郎; 石井 孝弘; 中尾 一和; 斉藤 能彦; 鷹野 誠
心電図 = Electrocardiology, 28(5), 430 - 430, 03 Oct. 2008
Lead

Identification Of A New NRSF-binding Partner, Zfp90, Which Negatively Regulates The Repression Activity Of NRSF, A Critical Transcriptional Regulator Of Cardiac Fetal Gene Program
Masao Murakami; Koichiro Kuwahara; Masaki Harada; Yasuaki Nakagawa; Satoru Usami; Hideyuki Kinoshita; Shinji Yasuno; Masataka Fujiwara; Kenji Ueshima; Kazuwa Nakao
CIRCULATION, 118(18), S332 - S333, Oct. 2008, Not invited
Lead

MIRTF-A, a rho-dependent co-activator of SRF, mediates mechanical stress-induced hypertrophic gene activation
Koichiro Kuwahara; Kazuwa Nakao; Eric Olson
JOURNAL OF CARDIAC FAILURE, 14(7), S169 - S170, Sep. 2008, Not invited
Lead

Blockade of T-Type Ca2+ Channel Corrects Imbalance in Cardiac Autonomic Nerve Activity and Prevents Sudden Arrhythmic Death in Chronic Heart Failure in Mice
Hideyuki Kinoshita; Koichiro Kuwahara; Shinji Yasuno; Masao Murakami; Yasuaki Nakagawa; Satoru Usami; Masataka Fujiwara; Yoshihiro Kuwabara; Kenji Ueshima; Masaki Harada; Kazuwa Nakao
CIRCULATION RESEARCH, 103(5), E36 - E36, Aug. 2008, Not invited
Lead

FRS-007 Functional inhibition of p300 in the post-natal heart leads to mitochondrial dysfunction and cell death in mice(Novel Pathophysiological Mechanisms of Heart Failure(M),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Nakagawa Yasuaki; Kuwahara Koichiro; Akao Masaharu; Katoh Masashi; Takemura Genzou; Takano Makoto; Harada Masaki; Murakami Masao; Nakanishi Michio; Usami Satoru; Yasuno Shinji; Kinoshita Hideyuki; Fujiwara Masataka; Kuwabara Yoshihiro; Ueshima Kenji; Nakao Kazuwa
Circulation journal : official journal of the Japanese Circulation Society, 72, 141 - 141, 01 Mar. 2008
Lead

1 Protective Effects of Natriuretic Peptide System in Pathological Cardiac Remodeling(Peptide Hormones in Cardiovascular Diseases,Topic 4 (TP-4) (H),Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Kuwahara Koichiro; Harada Masaki; Nakao Kazuwa
Circulation journal : official journal of the Japanese Circulation Society, 72, 89 - 89, 01 Mar. 2008
Lead

Functional inhibition of p300 leads to mitochondrial dysfunction and autophagic myocardial cell death in the adult heart
Yasuaki Nakagawa; Koichiro Kuwahara; Genzo Takemura; Masaharu Alkao; Yuji Arai; Makoto Takano; Masaki Harada; Masao Murakami; Michio Nakanishi; Satoru Usami; Shinji Yasuno; Hideyuki Kinoshita; Masataka Fujiwara; Kenji Ueshima; Kazuwa Nakao
CIRCULATION, 116(16), 196 - 196, Oct. 2007, Not invited
Lead

PE-441 Essential Role of p300 in Post-natal Cardiac Mitochondrial Gene Expression and Maintenance of Normal Cardiac Function(Heart failure, basic-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
Nakagawa Yasuaki; Kuwahara Koichiro; Harada Masaki; Takemura Genzou; Akao Masaharu; Takano Makoto; Nakanishi Michio; Usami Satoru; Yasuno Shinji; Kinoshita Hideyuki; Fujiwara Masataka; Ueshima Kenji; Nakao Kazuwa
Circulation journal : official journal of the Japanese Circulation Society, 71, 435 - 435, 01 Mar. 2007
Lead

PE-305 The actin-binding Protein STARS is a Cytoskeletal Intermediary between MEF2 and SRF during Cardiac Remodeling(Cardiomyopathy, basic/clinical-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
Kuwahara Koichiro; Nakao Kazuwa; Olson Eric
Circulation journal : official journal of the Japanese Circulation Society, 71, 401 - 401, 01 Mar. 2007
Lead

PE-210 TRPC6 Fulfills a Calcineurin Signaling Circuit During Pathological Cardiac Remodeling(Cardiac hypertrophy, basic/clinical-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
Kuwahara Koichiro; Nakao Kazuwa; Olson Eric
Circulation journal : official journal of the Japanese Circulation Society, 71, 377 - 377, 01 Mar. 2007
Lead

第21回犬山不整脈カンファランスメインテーマ不整脈の成因と治療戦略テーマI「不整脈の新しい分子メカニズム」:心臓イオンチャネル遺伝子の転写制御機構～エピジェネティックスと機能分化～
鷹野 誠; 倉富 忍; 堀江 稔; 斉藤 能彦; 桑原 宏一郎
心電図, 27(3), 15 - 28, 2007, Not invited
Lead

A role of p300 in post-natal cardiac mitochondrial gene expression and function
Yasuaki Nakagawa; Koichiro Kuwahara; Masaki Harada; Genzo Takemura; Masaharu Akao; Michio Nakanishi; Satoru Usami; Hideyuki Kinoshita; Kennji Ueshima; Kazuwa Nakao
JOURNAL OF CARDIAC FAILURE, 12(8), S162 - S162, Oct. 2006, Not invited
Lead

TRPC6 forms a positive regulatory loop of calcineurin-NFAT pathway during cardiac remodeling
Koichiro Kuwahara; Eric N. Olson
CIRCULATION RESEARCH, 99(5), E28 - E28, Sep. 2006, Not invited
Lead

OJ-021 Blockade of T-type Calcium Channel Reduced the Arrythmogenicity in the Dominant Negative NRSF Transgenic Mice(Heart failure, basic-2 (M) OJ4,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
Kinoshita Hideyuki; Kuwahara Koichiro; Harada Masaki; Nakagawa Yasuaki; Kawakami Rika; Nakanishi Michio; Yasuno Shinji; Usami Satoru; Fujiwara Masataka; Takano Makoto; Horie Minoru; Nakao Kazuwa
Circulation journal : official journal of the Japanese Circulation Society, 70, 239 - 239, 01 Mar. 2006
Lead

PJ-721 Physiological Remodeling of Cardiac Myocytes Induced by the Suppression of Neuron Restrictive Silencing Factor(Arrhythmia, basic-6 (A) PJ121,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
Takano Makoto; Kuratomi Shinobu; Kinoshita Hideyuki; Yasuno Shinji; Nakao Kazuwa; Saitou Yoshihiko; Kuwahara Koichiro
Circulation journal : official journal of the Japanese Circulation Society, 70, 667 - 667, 01 Mar. 2006
Lead

Role of the renin-angiotensin system (RAS) inhibition in chronic aortic regurgitation (AR) using angiotensin II type1a receptor knockout mice
M Nakanishi; M Harada; K Kuwahara; R Kawakami; Y Nakagawa; S Yasuno; S Usami; H Kinoshita; Kishimoto, I; K Nakao
JOURNAL OF CARDIAC FAILURE, 11(9), S318 - S318, Dec. 2005, Not invited
Lead

Transcriptional Regulation of the Pacemaker Channel HCN4 (Excitation-contraction Coupling/Ion Channel 2 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
Takano Makoto; Kuratomi Shinobu; Kuwahara Koichiro; Nakao Kazuwa
Circulation journal : official journal of the Japanese Circulation Society, 69, 589 - 589, 01 Mar. 2005
Lead

NRSE-NRSF regulates the transcription of fetal type cardiac ion channels
M Takano; K Kuwahara; Y Saito; K Nakao
JOURNAL OF PHARMACOLOGICAL SCIENCES, 97, 31P - 31P, 2005, Not invited
Lead

Genetic disruption of angiotensin II type1a receptor in mice attenuates volume overload cardiomyopathy and improves survival in chronic aortic regurgitation
M Nakanishi; Kishimoto, I; M Harada; K Kuwahara; R Kawakami; Y Nakagawa; K Tanimoto; S Yasuno; S Usami; H Kinoshita; K Nakao
CIRCULATION, 110(17), 201 - 202, Oct. 2004, Not invited
Lead

OJ-481 Beneficial Effects of Brain Natriuretic Peptide Overexpression in Cardiac Remodeling after Myocardial Infarction in Mice(Old Myocardial Infarction/Remodeling 1 (IHD) : OJ59)(Oral Presentation (Japanese))
Kawakami Rika; Harada Masaki; Kuwahara Koichiro; Nakanishi Michio; Nakagawa Yasuaki; Yasuno Shinji; Usami Satoru; Kishimoto Ichirou; Saitou Yoshihiko; Nakao Kazuwa
Circulation journal : official journal of the Japanese Circulation Society, 68, 347 - 347, 01 Mar. 2004
Lead

PJ-622 Significance of a novel interaction between NRSF and classII HDAC involved in the induction of ANP gene expression by Endothelin-1(Cardiac Hypertrophy, Basic and Clinical 2 (M) : PJ104)(Poster Session (Japanese))
Nakagawa Yasuaki; Kuwahara Koichiro; Harada Masaki; Kawakami Rika; Nakanishi Michio; Tanimoto Keiji; Yasuno Shinji; Usami Satoru; Kinoshita Hideyuki; Saitou Yoshihiko; Nakao Kazuwa
Circulation journal : official journal of the Japanese Circulation Society, 68, 632 - 632, 01 Mar. 2004
Lead

OE-006 The beneficial effects of natriuretic peptides following myocardial infarction are mediated partly by suppression of the renin-angiotensin system(Acute Myocardial Infarction, Basic 1 (IHD) : OE1)(Oral Presentation (English))
Nakanishi Michio; Kishimoto Ichirou; Harada Masaki; Kuwahara Koichiro; Kawakami Rika; Nakagawa Yasuaki; Yasuno Shinji; Usami Satoru; Kinoshita Hideyuki; Saitou Yoshihiko; Nakao Kazuwa; Fukamizu Akiyoshi
Circulation journal : official journal of the Japanese Circulation Society, 68, 143 - 143, 01 Mar. 2004
Lead

Relationship between Plasma Level of Cardiotrophin-1 and Prognosis in Patients with Dilated Cardiomyopathy
Tsutamoto Takayoshi; Wada Atsuyuki; Ohnishi Masato; Tsutsui Takashi; Ohno Keijin; Ishii Chitose; Asai Shigeru; Kuwahara Koichiro; Nakao Kazuwa; Saitou Yoshihiko; Horie Minoru
Circulation journal : official journal of the Japanese Circulation Society, 67, 95 - 95, 01 Mar. 2003
Lead

Angiotensin II Type 1 Receptor Improves the Arrhythmia Morbidityin Mice with Left Ventricular Hypertrophy
Zhang Cuntai; Yasuno Shinji; Kuwahara Koichiro; Horie Minoru
Circulation journal : official journal of the Japanese Circulation Society, 67, 233 - 233, 01 Mar. 2003
Lead

Role of Renin-Anglotensin System in Cardiac Remodeling after Aortic Regurgitation in Mice
Nakanishi Michio; Harada Masaki; Kuwahara Koichiro; Takahashi Nobuki; Kawakami Rika; Nakagawa Yasuaki; Tanimoto Keiji; Yasuno Shinji; Usami Satoru; Saitoh Yoshitomo; Kinoshita Hideyuki; Nakao Kazuwa; Kishimoto Ichirou; Saitou Yoshihiko; Fukamizu Akiyoshi
Circulation journal : official journal of the Japanese Circulation Society, 67, 226 - 226, 01 Mar. 2003
Lead

ERK5 Plays a Critical Role in Cardiotrophin-1-Induced Hypertrophy of Neonatal Rat Ventricular Myocytes
Takahashi Nobuki; Saito Yoshihiko; Kuwahara Koichiro; Harada Masaki; Kawakami Rika; Nakagawa Yasuaki; Nakanishi Michio; Tanimoto Keiji; Yasuno Shinji; Usami Satoru; Saito Yoshitomo; Kinoshita Hideyuki; Nakao Kazuwa
Circulation journal : official journal of the Japanese Circulation Society, 67, 224 - 225, 01 Mar. 2003
Lead

Evidence for Cardiac Myocyte Regeneration in Injured Myocardium by Bone Marrow Derived Cells
Harada Masaki; Saitou Yoshihiko; Nakagawa Yasuaki; Adachi Yuichiro; Kuwahara Koichiro; Takahashi Nobuki; Kawakami Rika; Nakanishi Michio; Tanimoto Keiji; Li Yuhao; Yasuno Shinji; Usami Satoru; Saitoh Yoshitomo; Kinoshita Hideyuki; Nakao Kazuwa
Circulation journal : official journal of the Japanese Circulation Society, 67, 191 - 191, 01 Mar. 2003
Lead

NRSF Is Involved in Molecular Pathways for Sudden Death Associated with Heart Failure
Kuwahara Koichiro; Saitou Yoshihiko; Arai Yuji; Morisaki Takayuki; Nakagawa Yasuaki; Yasuno Shinji; Horie Minoru; Takano Makoto; Noma Akinori; Miyamoto Yoshihiro; Takemura Gennzou; Fujiwara Hisayoshi; Harada Masaki; Kawakami Rika; Nakanishi Michio; Usami Satoru; Saitoh Yoshitomo; Nakao Kazuwa
Circulation journal : official journal of the Japanese Circulation Society, 67, 154 - 154, 01 Mar. 2003
Lead

In-Vivo Electrophysiological Study in Dominant-Negative NRSF Transgenic Mice : Ventricular Arrhythmia Vulnerability and Sudden Cardiac Death
Yasuno Shinji; Saitou Yoshihiko; Horie Minoru; Takano Makoto; Noma Akinori; Arai Yuji; Kuwahara Koichiro; Takahashi Nobuki; Nakagawa Yasuaki; Harada Masaki; Kawakami Rika; Nakanishi Michio; Tanimoto Keiji; Usami Satoru; Saitoh Yoshitomo; Morisaki Takayuki; Nakao Kazuwa
Circulation journal : official journal of the Japanese Circulation Society, 67, 344 - 344, 01 Mar. 2003
Lead

Disruption of natriuretic peptide receptor-A leads to higher mortality and exaggerated left ventricular remodeling after myocardial infarction in mice
M Nakanishi; Kishimoto, I; M Harada; K Kuwahara; N Takahashi; R Kawakami; Y Nakagawa; K Tanimoto; Y Adachi; S Yasuno; S Usami; Y Saito; K Nakao; Y Saito
CIRCULATION, 106(19), 148 - 148, Nov. 2002, Not invited
Lead

The roles of angiotensin II type 2 (AT2) receptor on acute heart failure and long-term remodeling after myocardial infarction in mice
Y Adachi; Y Saito; Kishimoto, I; M Harada; K Kuwahara; N Takahashi; R Kawakami; M Nakanishi; Y Nakagawa; K Tanimoto; Y Saitoh; S Yasuno; S Usami; K Nakao
CIRCULATION, 106(19), 133 - 134, Nov. 2002, Not invited
Lead

Neuron-restrictive silencer element is involved in the selective induction of cardiac embryonic genes expression by inhibition of histone deacetylase in cultured ventricular myocytes
K Kuwahara; M Harada; N Takahashi; R Kawakami; Y Nakagawa; M Nakanishi; S Yasuno; S Usami; T Saitoh; K Tanimoto; Y Adachi; K Nakao
CIRCULATION, 106(19), 5 - 5, Nov. 2002, Not invited
Lead

A novel interaction between NRSF and class IIHDAC mediates CaMK signals in ET-1-induced ANP gene expression
Y Nakagawa; Y Saito; K Kuwahara; M Harada; N Takahashi; R Kawakami; M Nakanishi; K Tanimoto; Y Adachi; S Yasuno; S Usami; Y Saito; K Nakao
CIRCULATION, 106(19), 107 - 107, Nov. 2002, Not invited
Lead

SOCS1 and SOCS3 inhibit hypertrophic responses to cardiotrophin-1 through inhibition of MEK5-ERK5 pathway independent of STAT3 suppression in neonatal rat ventricular myocytes
N Takahashi; Y Saito; K Kuwahara; M Harada; R Kawakami; Y Nakagawa; M Nakanishi; K Tanimoto; S Yasuno; S Usami; Y Saito; K Nakao
CIRCULATION, 106(19), 259 - 260, Nov. 2002, Not invited
Lead

Relationship between plasma cardiotrophin-1 and left ventricular remodeling in patients with first acute myocardial infarction
Hayashi Masaru; Tsutamoto Takayoshi; Maeda Keiko; Mabuchi Naoko; Tsutsui Takashi; Kinoshita Masahiko; Saitou Yoshihiko; Kuwahara Koichiro; Asai Shigeru
Circulation journal : official journal of the Japanese Circulation Society, 66, 475 - 475, 31 Mar. 2002
Lead

Relationship between plasma level of cardiotrophin-1 and left ventricular mass index in patients with dilated cardiomyopathy
Tsutamoto Takayoshi; Maeda Keiko; Hayashi Masaru; Tsutsui Takashi; Wada Atsuyuki; Ohnishi Masato; Fujii Masanori; Matsumoto Takehiro; Yamamoto Takashi; Takayama Tomoyuki; Kinoshita Masahiko; Saito Yoshihiko; Kuwahara Koichiro; Nakao Kazuwa; Asai Shigeru
Circulation journal : official journal of the Japanese Circulation Society, 66, 391 - 391, 31 Mar. 2002
Lead

Overxepression of brain natriuretic peptide mediates cardiac matrix metalloproteinase induction and induces cardiac rupture after acute myocardial infarction in mice
Kawakami Rika; Saitou Yoshihiko; Harada Masaki; Kuwahara Koichiro; Takahashi Nobuki; Li Yuhao; Nakagawa Yasuaki; Nakanishi Michio; Adachi Yuichiro; Tanimoto Keiji; Usami Satoru; Saitoh Yoshitomo; Yasuno Shinji; Nakao Kazuwa; Kishimoto Ichirou
Circulation journal : official journal of the Japanese Circulation Society, 66, 434 - 434, 31 Mar. 2002
Lead

JAB/SOCS1 and CIS3/SOCS3 inhibit hypertrophic response to cardiotrophin-1 independent of STAT3 suppression in neonatal rat ventricular myocytes
Takahashi Nobuki; Saito Yoshihiko; Hamanaka Ichiro; Kuwahara Koichiro; Harada Masaki; Kawakami Rika; Nakagawa Yasuaki; Nakanishi Michio; Tanimoto Keiji; Li Yuhao; Nakao Kazuwa; Hanakawa Yasushi; Yasukawa Hideo; Yoshimura Akihiko
Circulation journal : official journal of the Japanese Circulation Society, 66, 445 - 445, 31 Mar. 2002
Lead

Possible involvement of Atypical Protein Kinase C in Aldosterone-induced-Angiotensin-Converting-Enzyme Gene Expression in Cultured Neonatal Rat Cardiocytes
Harada Eisaku; Yoshimura Michihiro; Nakagawa Osamu; Nakagawa Masayo; Nakayama Masafumi; Shimasaki Yukio; Itoh Teruhiko; Nakamura Shota; Ogawa Hisao; Yasue Hirofumi; Mizuno Yuji; Harada Masaki; Kuwahara Koichiro; Saitou Yoshihiko; Nakao Kazuwa
Circulation journal : official journal of the Japanese Circulation Society, 66, 618 - 618, 31 Mar. 2002
Lead

Inhibition of histone deacetylase selectively induces expression of cardiac embryonic genes that contain neuron-restrictive silencer element in cultured ventricular myocytes
Kuwahara Koichiro; Saitou Yoshihiko; Takahashi Nobuki; Nakagawa Yasuaki; Harada Masaki; Kawakami Rika; Nakanishi Michio; Li Yuhao; Tanimoto Keiji; Yasuno Shinji; Usami Satoru; Saitoh Yoshitomo; Adachi Yuichiro; Nakao Kazuwa
Circulation journal : official journal of the Japanese Circulation Society, 66, 265 - 265, 31 Mar. 2002
Lead

Genetic disruption of angiotensin II type 2 (AT2) receptor worsened short-term survival after acute myocardial infarction in mice
Adachi Yuichiro; Saito Yoshihiko; Harada Masaki; Kuwahara Koichiro; Takahashi Nobuki; Kawakami Rika; Li Yuhao; Nakanishi Michio; Nakagawa Yasuaki; Tanimoto Keiji; Saitoh Yoshitomo; Yasuno Shinji; Usami Satoru; Nakao Kazuwa; Iwai Masaru; Horiuchi Masatsugu; Kishimoto Ichiro
Circulation journal : official journal of the Japanese Circulation Society, 66, 196 - 196, 31 Mar. 2002
Lead

Disruption of natriuretic peptides receptor A leads to higher mortality and exaggerated left ventricular remodeling after myocardial infarction in mice
Nakanishi Michio; Saitou Yoshihiko; Harada Masaki; Kuwahara Koichiro; Takahashi Nobuki; Kawakami Rika; Nakagawa Yasuaki; Yasuno Shinji; Usami Satoru; Saitoh Yoshitomo; Li Yuhao; Nakao Kazuwa; Kishimoto Ichirou
Circulation journal : official journal of the Japanese Circulation Society, 66, 197 - 197, 31 Mar. 2002
Lead

Increased responsiveness to angiotensin II and cardiac remodeling of mice lacking guanylyl cyclase-A, a natriuretic peptide receptor
Y Saito; YH Li; Kishimoto, I; M Harada; K Kuwahara; Hamanaka, I; Y Adachi; Y Adachi; Y Adachi; Y Adachi
CIRCULATION, 104(17), 22 - 22, Oct. 2001, Not invited
Lead

Pharmacological and genetic blockades of angiotensin II type 1A receptors markedly improve cardiac fibrosis in guanylyl cyclase A receptor knockout mice
Kishimoto, I; YH Li; M Harada; K Kuwahara; T Izumi; N Takahashi; R Kawakami; Y Nakagawa; M Nakanishi; Y Adachi; K Tanimoto; K Nakao
CIRCULATION, 104(17), 281 - 281, Oct. 2001, Not invited
Lead

Neuron-restrictive silencer factor, a novel regulator of fetal cardiac genes, plays a critical role in maintaining cardiac structure and function
K Kuwahara; Y Saito; K Nakao
CIRCULATION, 104(17), 155 - 155, Oct. 2001, Not invited
Lead

Blockade of the natriuretic peptide receptor guanylyl cyclase-A inhibits NF-kappa B activation and alleviates myocardial ischemia/reperfusion injury
T Izumi; Y Saito; Kishimoto, I; M Harada; K Kuwahara; Hamanaka, I; N Takahashi; R Kawakami; YH Li; G Takemura; H Fujiwara; DL Garbers; S Mochizuki; K Nakao
JOURNAL OF CLINICAL INVESTIGATION, 108(2), 203 - 213, Jul. 2001, Not invited
Lead

Blockade of guanylyl cyclase-A, a natriuretic peptide receptor, reduced myocardial infarct size in a mouse model of ischemia-reperfusion injury
Kishimoto, I; Y Saito; T Izumi; R Kawakami; M Harada; K Kuwahara; Hamanaka, I; N Takahashi; Y Li; DL Garbers; K Nakao
CIRCULATION, 102(18), 346 - 346, Oct. 2000, Not invited
Lead

A novel strategy for the treatment of LPS-induced left ventricular dysfunction in rat: Application of cytokine resistance.
Hamanaka, I; Y Saito; Kishimoto, I; K Kuwahara; T Izumi; N Takahashi; M Harada; R Kawakami; K Nakao
CIRCULATION, 102(18), 533 - 533, Oct. 2000, Not invited
Lead

Fibronectin signaling increases BNP gene transcription by inhibiting neuron-restrictive silencer element-dependent repression in rat ventricular myocytes.
E Ogawa; Y Saito; K Kuwahara; M Harada; Y Miyamoto; Hamanaka, I; N Takahashi; T Izumi; R Kawakami; Kishimoto, I; K Nakao
CIRCULATION, 102(18), 132 - 132, Oct. 2000, Not invited
Lead

Increased mortality due to cardiac rupture after myocardial infarction in mice overexpressing brain natriuretic peptide
R Kawakami; Y Saito; Kishimoto, I; Y Ogawa; N Tamura; H Chusho; K Kuwahara; Hamanaka, I; N Takahashi; T Izumi; Y Li; K Nakao
CIRCULATION, 102(18), 347 - 347, Oct. 2000, Not invited
Lead

0700 ヒト血中におけるCardiotrophin-1の存在
齋藤 能彦; 桑原 宏一郎; 石川 匡洋; 岸本 一郎; 原田 昌樹; 浜中 一郎; 中尾 一和; 浅井 茂; 東久保 千絵; 辻 哲男; 水野 雄二; 吉村 道博; 泰江 弘文
Japanese circulation journal, 64, 361 - 361, 01 Mar. 2000
Lead

0518 gp130による心筋細胞生存維持シグナルにおけるPI3K/Akt経路の関与
桑原 宏一郎; 斎藤 能彦; 岸本 一郎; 宮本 恵宏; 原田 昌樹; 浜中 一郎; 高橋 伸樹; 和泉 武彦; 川上 利香; 中尾 一和
Japanese circulation journal, 64, 315 - 315, 01 Mar. 2000
Lead

0376 BNPの心肥大抑制作用に関する検討 : トランスジェニックマウスを用いて
高橋 伸基; 斎藤 能彦; 岸本 一郎; 浜中 一郎; 桑原 宏一郎; 小川 佳宏; 田村 尚久; 中所 英樹; 宮本 恵宏; 原田 昌樹; 和泉 武彦; 川上 利香; 桝田 出; 中尾 一和
Japanese circulation journal, 64, 279 - 279, 01 Mar. 2000
Lead

0377 圧負荷型肥大心での蛋白質合成におけるElongation Factorの意義
和泉 武彦; 斎藤 能彦; 石川 匡洋; 岸本 一郎; 宮本 恵宏; 原田 昌樹; 桑原 宏一郎; 小川 恵美子; 浜中 一郎; 高橋 伸基; 川上 利香; 桝田 出; 中尾 一和; 錦見 俊雄
Japanese circulation journal, 64(0), 279 - 279, 01 Mar. 2000, Not invited
Lead

慢性心不全の治療上血漿BNP測定が有用であった拡張型心筋症の1例
犬塚 康孝; 斉藤 能彦; 高橋 伸基; 岸本 一郎; 原田 昌樹; 浜中 一郎; 桑原 宏一郎; 川上 利香; 菅原 照; 中尾 一和
日本内分泌学会雑誌, 76, 104 - 104, Feb. 2000
Lead

Involvement of PI3K/Akt/BAD pathway in gp130-mediated pro-survival/anti-apoptosis signaling in ventricular myocytes.
K Kuwahara; Y Saito; Kishimoto, I; Y Miyamoto; MM Harada; E Ogawa; Hamanaka, I; N Kajiyama; N Takahashi; T Izumi
CIRCULATION, 100(18), 63 - 63, Nov. 1999, Not invited
Lead

New genes responsible far development of pressure-overload or volume-overload hypertrophy
T Izumi; Kishimoto, I; Y Miyamoto; M Harada; K Kuwahara; E Ogawa; Hamanaka, I; M Ishikawa; N Takahashi; T Nishikimi; Y Saito
CIRCULATION, 100(18), 126 - 126, Nov. 1999, Not invited
Lead

Outside-in signaling of fibronectin actively leads to myocardial cell hypertrophy by integrin-dependent pathways
E Ogawa; Y Saito; K Kuwahara; M Harada; Kishimoto, I; Y Miyamoto; Hamanaka, I; N Kajiyama; N Takahashi; T Izumi; R Kawakami; K Nakao
CIRCULATION, 100(18), 198 - 198, Nov. 1999, Not invited
Lead

Involvement of Rho/ROCK pathway in ET-1-induced hypertrophic signaling in cultured neonatal rat ventricular myocytes.
K Kuwahara; Kishimoto, I; Y Miyamoto; M Harada; E Ogawa; Hamanaka, I; N Kajlyama; N Takahashi; T Izumi; R Kawakami; K Nakao
CIRCULATION, 100(18), 53 - 53, Nov. 1999, Not invited
Lead

内皮型一酸化窒素合成酵素遺伝子5'隣接領域の-786C変異配列に結合する負の転写因子の同定
宮本 恵宏; 斉藤 能彦; 原田 昌樹; 中山 雅文; 嶋崎 幸生; 梶山 登; 神谷 重樹; 桑原 宏一郎; 小川 恵美子; 浜中 一郎
日本内分泌学会雑誌, 75(1), 111 - 111, Apr. 1999, Not invited
Lead

内皮型一酸化窒素合成酵素遺伝子5'隣接領域の遺伝子多型の機能解析と本態性高血圧発症との関連研究
梶山 登; 斎藤 能彦; 宮本 恵宏; 岸本 一郎; 吉村 道博; 中山 雅文; 嶋崎 幸生; 神谷 重樹; 原田 昌樹; 桑原 宏一郎
日本内分泌学会雑誌, 75(1), 152 - 152, Apr. 1999, Not invited
Lead

P198 肥大因子ET-1、IL-1βによるBNPおよびMn-SODの遺伝子発現調節
原田 栄作; 吉村 道博; 嶋崎 幸生; 中山 雅文; 水野 雄二; 久木山 清貴; 小川 久雄; 泰江 弘文; 中川 修; 中川 眞代; 原田 昌樹; 桑原 宏一郎; 斎藤 能彦; 中尾 一和
Japanese circulation journal, 63(1), 498 - 498, 01 Mar. 1999
Lead

IS003 Differing role of Extracellular signal-regulated kinase in endothelin-1-induced and cardiotrophin-1-induced hypertrophic signals in cultured cardiac myocytes
Kuwahara Koichiro; Saitoh Yoshihiko; Kishimoto Ichiro; Ogawa Yoshihiro; Tamura Naohisa; Harada Masaki; Ogawa Emiko; Miyamoto Yoshihiro; Hamanaka Ichiro; Kajiyama Noboru; Takahashi Nobuki; Kawakami Rika; Inobe Yoshito; Izumi Takehiko; Masuda Izuru; Nakao Kazuwa
Japanese circulation journal, 63(1), 93 - 93, 01 Mar. 1999
Lead

IS007 Interleukin-1b Induces Myocyte Hypertrophy and Production of B-type Natriuretic Peptide
Harada Eidsku; Yoshimura Michihiro; Shimasaki Yukio; Nakayama Masafumi; Mizuno Yuji; Kugiyama Kiyotaka; Ogawa Hisao; Yasue Hirofumi; Nakagawa Osamu; Nakagawa Masayo; Harada Masaki; Kuwahara Koichiro; Saitoh Yoshihiko; Nakao Kazuwa
Japanese circulation journal, 63(1), 94 - 94, 01 Mar. 1999
Lead

内皮型一酸化窒素合成酵素遺伝子5'隣接領域の-786C変異配列に結合する負の転写調節因子の同定
宮本 恵宏; 斎藤 能彦; 原田 昌樹; 梶山 登; 神谷 重樹; 桑原 宏一郎; 小川 惠美子; 浜中 一郎; 高橋 伸基; 和泉 武彦
Japanese Circulation Journal, 63(Suppl.I), 382 - 382, Mar. 1999, Not invited
Lead

Cloning of new genes responsible for development of concentric or eccentric hypertrophy.
M Ishikawa; Y Saito; Y Miyamoto; S Kamitani; T Izumi; K Kuwahara; E Ogawa; Hamanaka, I; N Kajiyama; N Takahashi
CIRCULATION, 98(17), 697 - 697, Oct. 1998, Not invited
Lead

Nitric oxide mediated hypotensive effect of Cardiotrophin-1, a cytokine of interleukin-1 family
Hamanaka, I; Y Saito; M Harada; K Kuwahara; E Ogawa; M Ishikawa; S Kamitani; N Kajiyama; N Takahashi; T Magaribuchi; K Mori
CIRCULATION, 98(17), 377 - 378, Oct. 1998, Not invited
Lead

Effect of a Glu298Asp missense mutation of human endothelial nitric oxide synthase gene on its enzyme activity
S Kamitani; Y Saito; Y Miyamoto; N Kajiyama; K Kuwahara; E Ogawa; Hamanaka, I; M Ishikawa; Y Shimasaki; M Nakayama; M Yoshimura
CIRCULATION, 98(17), 537 - 537, Oct. 1998, Not invited
Lead

内皮型一酸化窒素合成酵素遺伝子Glu298Asp変異と本態性高血圧症との連関研究
宮本 恵宏; 斎藤 能彦; 梶山 登; 上野 利恵; 神谷 重樹; 原田 昌樹; 石川 匡洋; 桑原 宏一郎; 小川 恵美子; 浜中 一郎; 高橋 伸基; 井野邊 義人; 桝田 出; 伊藤 裕; 吉政 孝明; 中尾 一和; 嶋崎 幸生; 中山 雅文; 吉村 道博; 泰江 弘文
Therapeutic Research, 19(10), 3072 - 3073, Oct. 1998, Not invited
Lead

内皮型一酸化窒素合成酵素遺伝子の5'隣接領域の遺伝子多型と本態性高血圧発症の関連研究
梶山 登; 斎藤 能彦; 宮本 恵宏; 吉村 道博; 中山 雅文; 嶋崎 幸生; 神谷 重樹; 原田 昌樹; 桑原 宏一郎; 小川 惠美子
日本内分泌学会雑誌, 74(2), 624 - 624, Sep. 1998, Not invited
Lead

レニン-アンジオテンシン系構成分子は心筋細胞及び非心筋細胞において細胞特異的に発現する
原田 昌樹; 斎藤 能彦; 桑原 宏一郎; 小川 恵美子; 石川 匡洋; 高橋 伸基; 宮本 恵宏; 神谷 重樹; 嶋崎 幸生; 浜中 一郎
日本内分泌学会雑誌, 74(2), 610 - 610, Sep. 1998, Not invited
Lead

冠攣縮性狭心症に連関する内皮型一酸化窒素合成酵素遺伝子転写領域の-786C変異配列に結合する負の転写調節因子の精製
宮本 恵宏; 斉藤 能彦; 中山 雅文; 梶山 登; 嶋崎 幸生; 神谷 重樹; 桑原 宏一郎; 小川 恵美子; 浜中 一郎; 高橋 伸基
日本内分泌学会雑誌, 74(2), 626 - 626, Sep. 1998, Not invited
Lead

本態性高血圧症におけるアンジオテンシン変換酵素遺伝子I/D多型とアンジオテンシンII type1受容体遺伝子A1166C多型のポリジーン効果の検討
梶山 登; 斎藤 能彦; 宮本 恵宏; 原田 昌樹; 桑原 宏一郎; 小川 恵美子; 浜中 一郎; 神谷 重樹; 高橋 伸基; 井野邊 義人
日本内分泌学会雑誌, 74(2), 611 - 611, Sep. 1998, Not invited
Lead

In vitro心筋細胞肥大モデルにおいてカルディオトロフィン-1はパラクライン因子として働いている
桑原 宏一郎; 斎藤 能彦; 宮本 恵宏; 原田 昌樹; 石川 匡洋; 神谷 重樹; 小川 恵美子; 浜中 一郎; 梶山 登; 井野辺 義人
日本内分泌学会雑誌, 74(2), 625 - 625, Sep. 1998, Not invited
Lead

フィブロネクチン-インテグリンoutside-in signalingの心筋細胞肥大に対する検討
小川 惠美子; 斎藤 能彦; 原田 昌樹; 桑原 宏一郎; 宮本 恵宏; 石川 匡洋; 浜中 一郎; 梶山 登; 神谷 重樹; 高橋 伸基
日本内分泌学会雑誌, 74(2), 630 - 630, Sep. 1998, Not invited
Lead

Positive association of Glu298Asp polymorphism in the endothelial nitric oxide synthase gene with essential hypertension
Y Miyamoto; Y Saito; N Kajiyama; Y Shimazaki; M Nakayama; S Kamitani; M Harada; M Ishikawa; E Ogawa; K Kuwahara; Hamanaka, I; M Takahashi; Y Inobe; T Yoshimasa; H Itoh; Masuda, I; M Yoshimura; H Yasue; K Nakao
JOURNAL OF HYPERTENSION, 16, S55 - S55, Jun. 1998, Not invited
Lead

Functional analysis of human endothelial nitric oxide synthase (eNOS) with a missense mutation Glu298Asp
S Kamitani; Y Saito; Y Miyamoto; M Nakayama; Y Shimasaki; N Kajiyama; M Harada; M Ishikawa; K Kuwahara; E Ogawa; Hamanaka, I; N Takahashi; Masuda, I; M Yoshimura; H Yasue; K Nakao
JOURNAL OF HYPERTENSION, 16, S44 - S44, Jun. 1998, Not invited
Lead

IS049 Implication of cardiotrophin-1 in myocyte-nonmyocyte interaction during cardiac hypertrophy in vitro
Kuwahara Koichiro; Saito Yoshihiko; Masuda Izuru; Miyamoto Yoshihiro; Harada Masaki; Iishikawa Masahiro; Ogawa Emiko; Hamanaka Ichiro; Kajiyama Noboru; Kamitani Shigeki; Simazaki Yukio; Takahashi Nobuki; Inobe Yoshito; Ito Hiroshi; Nakao Kazuwa
Japanese circulation journal, 62, 29 - 29, 28 Feb. 1998
Lead

IS040 Positive association between essential hypertension and Glu298Asp polymorphism in the endothelial nitric oxide synthase gene
Miyamoto Yoshihiro; Saito Yoshihiko; Kajiyama Noboru; Shimasaki Yukio; Nakayama Masahumi; Kamitani Shigeki; Harada Masaki; Ishikawa Masahiro; Ogawa Emiko; Kuwahara Koichiro; Hamanaka Ichiro; Takahashi Nobuki; Inobe Yoshito; Yoshimasa Takaaki; Ito Hiroshi; Masuda Izuru; Yoshimura Michihiro; Yasue Hirifumi; Nakao Kazuwa
Japanese circulation journal, 62, 25 - 25, 28 Feb. 1998
Lead

0308 冠攣縮性狭心症に連関する内皮型一酸化窒素合成酵素遺伝子転写領域の変異部位に結合する陰性転写調節因子の解析
宮本 恵宏; 斎藤 能彦; 神谷 重樹; 梶山 登; 原田 昌樹; 石川 匡洋; 桑原 宏一郎; 小川 惠美子; 浜中 一郎; 高橋 伸基; 井野邉 義人; 桝田 出; 中尾 一和; 中山 雅文; 嶋崎 幸生; 吉村 道博; 泰江 弘文
Japanese circulation journal, 62(0), 28 Feb. 1998, Not invited
Lead

0984 フィブロネクチンのインテグリンを介する心筋細胞肥大効果の検討
小川 惠美子; 斎藤 能彦; 原田 昌樹; 桑原 宏一郎; 宮本 恵宏; 石川 匡洋; 浜中 一郎; 梶山 登; 高橋 伸基; 神谷 重樹; 嶋崎 幸生; 井野邉 義人; 中川 修; 伊藤 裕; 桝田 出; 中尾 一和
Japanese circulation journal, 62(0), 28 Feb. 1998, Not invited
Lead

0991 心筋細胞および非心筋細胞におけるレニン-アンジオテンシン系構成分子の細胞特異的発現の検討
原田 昌樹; 斎藤 能彦; 桑原 宏一郎; 小川 惠美子; 石川 匡洋; 高橋 伸基; 宮本 恵宏; 神谷 重樹; 嶋崎 幸生; 浜中 一郎; 梶山 登; 井野邉 義人; 桝田 出; 中川 修; 伊藤 裕; 中尾 一和
Japanese circulation journal, 62(0), 28 Feb. 1998, Not invited
Lead

1013 本態性高血圧症におけるアンジオテンシン変換酵素遺伝子I/D多型とアンジオテンシンII typel受容体遺伝子A1166C多型の相加作用の検討
梶山 登; 斎藤 能彦; 宮本 恵宏; 石川 匡洋; 原田 昌樹; 桑原 宏一郎; 小川 恵美子; 浜中 一郎; 井野邉 義人; 嶋崎 幸生; 神谷 重樹; 上野 利恵; 高橋 伸基; 桝田 出; 中尾 一和
Japanese circulation journal, 62(0), 28 Feb. 1998, Not invited
Lead

P148 Cradiotrophin(CT-1)の生体投与における血圧変動の解析
浜中 一郎; 斎藤 能彦; 宮本 恵宏; 石川 匡洋; 原田 昌樹; 桑原 宏一郎; 小川 惠美子; 梶山 登; 井野邉 義人; 神谷 重樹; 高橋 伸基; 伊藤 裕; 桝田 出; 中尾 一和; 曲渕 達雄; 森 健次郎
Japanese circulation journal, 62(0), 28 Feb. 1998, Not invited
Lead

P550 新しいcDNAスクリーニング法(RLCS法)を用いた遠心性肥大、求心性心肥大に特異的な心肥大因子の検索
石川 匡洋; 斎藤 能彦; 宮本 恵宏; 原田 昌樹; 桑原 宏一郎; 小川 惠美子; 浜中 一郎; 梶山 登; 神谷 重樹; 高橋 伸基; 井野邉 義人; 嶋崎 幸生; 枡田 出; 中尾 一和
Japanese circulation journal, 62(0), 28 Feb. 1998, Not invited
Lead

P596 心筋細胞肥大刺激によるナトリウム利尿ペプチド遺伝子発現の転写調節機構 : カルディオトロフィン-1とエンドセリン-1との比較
桑原 宏一郎; 斎藤 能彦; 枡田 出; 宮本 恵宏; 原田 昌樹; 石川 匡洋; 小川 惠美子; 浜中 一郎; 梶山 登; 神谷 重樹; 嶋崎 幸生; 高橋 伸基; 井野邉 義人; 伊藤 裕; 中尾 一和
Japanese circulation journal, 62(0), 28 Feb. 1998, Not invited
Lead

P835 eNOS遺伝子のexon7点変異(Glu298Asp)の機能解析
神谷 重樹; 斎藤 能彦; 宮本 恵宏; 嶋崎 幸生; 梶山 登; 原田 昌樹; 石川 匡洋; 桑原 宏一郎; 小川 惠美子; 浜中 一郎; 井野邉 義人; 高橋 伸基; 桝田 出; 中尾 一和; 中山 雅文; 吉村 道博; 泰江 弘文
Japanese circulation journal, 62(0), 28 Feb. 1998, Not invited
Lead

Plasma BNP concentration is the most sensitive marker for management of chronic congestive heart failure
Hamanaka, I; Y Saito; Masuda, I; Y Miyamoto; M Harada; K Kuwahara; E Ogawa; N Kajiyama
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 31(2), 155A - 155A, Feb. 1998, Not invited
Lead

Cardiotrophin-1(CT-1), a new agonist for a gp 130 signaling pathway, stimulates brain natriuretic peptide (BNP) secretion more abundantly than endothelin-1(ET-1)
M Ishikawa; Y Miyamoto; K Kuwahara; E Ogawa; M Harada; Hamanaka, I; N Kajiyama; O Nakagawa; Masuda, I; K Nakao
CIRCULATION, 96(8), 2025 - 2025, Oct. 1997, Not invited
Lead

0537 Cardiotrophin-1(CT-1)のヒト胎児心及び梗塞心における遺伝子発現
宮本 恵宏; 斎藤 能彦; 小川 恵美子; 石川 匡洋; 桑原 宏一郎; 原田 昌樹; 中川 修; 桝田 出; 中尾 一和; 伊東 宏晃; 佐川 典正; 森 崇英
Japanese circulation journal, 61(0), 246 - 246, 05 Mar. 1997, Not invited
Lead

0815 微小心筋梗塞モデルマウス(WBF1)における新しい心筋肥大因子Cardiotrophin-1遺伝子発現 : In situ hybridizationにより検討
小川 恵美子; 斎藤 能彦; 宮本 恵宏; 石川 匡洋; 桑原 宏一郎; 中川 修; 原田 昌樹; 浜中 一郎; 梶山 登; 伊藤 裕; 桝田 出; 中尾 一和; 勝浦 五郎; 新宅 治幸
Japanese circulation journal, 61(0), 316 - 316, 05 Mar. 1997, Not invited
Lead

0816 Cardiotrophin-1(CT-1)の心筋細胞肥大作用とANP・BNP分泌刺激作用
石川 匡洋; 斎藤 能彦; 宮本 恵宏; 桑原 宏一郎; 小川 恵美子; 中川 修; 原田 昌樹; 中山 雅文; 神谷 重樹; 浜中 一郎; 梶山 登; 伊藤 裕; 桝田 出; 中尾 一和
Japanese circulation journal, 61(0), 05 Mar. 1997, Not invited
Lead

120) ANPの心不全における長期投与効果
浜中 一郎; 桝田 出; 斎藤 能彦; 中川 修; 宮本 恵宏; 原田 昌樹; 石川 匡洋; 桑原 宏一郎; 小川 恵美子; 梶山 登; 中尾 一和
Japanese circulation journal, 60(0), 779 - 779, 20 Jan. 1997, Not invited
Lead

Augmented expression of cardiotrophin-1 mRNA in the ventricle of genetically hypertensive rats (SHRSP/Izm)
M. Ishikawa; Y. Saito; Y. Miyamoto; O. Nakagawa; K. Kuwahara; E. Ogawa; M. Harada; I. Masuda; K. Nakao
Japanese Heart Journal, 38(4), 586, 1997, Not invited
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0030838987&origin=inward
Lead

0063 脳卒中易発症高血圧自然発症ラット(SHRSP/lzm)心室でのCardiotrophin-1(CT-1)遺伝子発現の亢進
石川 匡洋; 斎藤 能彦; 宮本 恵宏; 桑原 宏一郎; 小川 恵美子; 中川 修; 原田 昌樹; 堀 義和; 谷口 泰代; 伊藤 裕; 桝田 出; 中尾 一和
Japanese circulation journal, 60(0), 62 - 62, 20 Feb. 1996, Not invited
Lead

0258 血管内皮細胞培養上清中血管平滑筋細胞遊走因子の単離同定 : 内皮由来Heparin-Binding Epidermal Growth Factor(HBEGF)分子型の決定
斎藤 能彦; 中川 修; 宮本 恵宏; 原田 昌樹; 石川 匡洋; 桑原 宏一郎; 小川 恵美子; 桝田 出; 中尾 一和; 宮本 薫; 赤井 靖宏; 寒川 賢治; 宮田 篤郎; 南野 直人; 松尾 壽之
Japanese circulation journal, 60(0), 111 - 111, 20 Feb. 1996, Not invited
Lead

0383 心筋肥大因子ヒトカルディオトロフィン1cDNAのクローニング
宮本 恵宏; 斎藤 能彦; 石川 匡宏; 小川 恵美子; 桑原 宏一郎; 中川 修; 原田 昌樹; 堀 義和; 谷口 泰代; 伊藤 裕; 桝田 出; 中尾 一和
Japanese circulation journal, 60(0), 142 - 142, 20 Feb. 1996, Not invited
Lead

0384 Cardiotrophin-1の心臓での局在についての検討 : 心筋/非心筋細胞分離培養系を用いて
桑原 宏一郎; 斎藤 能彦; 宮本 恵宏; 石川 匡洋; 小川 恵美子; 中川 修; 原田 昌樹; 堀 義和; 谷口 泰代; 伊藤 裕; 桝田 出; 中尾 一和
Japanese circulation journal, 60(0), 143 - 143, 20 Feb. 1996, Not invited
Lead

0933 メチルプレドニゾロン大量療法におけるANPおよびBNPの分泌亢進
谷口 泰代; 桝田 出; 中川 修; 宮本 恵宏; 原田 昌樹; 桑原 宏一郎; 小川 恵美子; 石川 匡洋; 伊藤 裕; 斉藤 能彦; 中尾 一和
Japanese circulation journal, 60(0), 281 - 281, 20 Feb. 1996, Not invited
Lead

P310 心肥大における心筋細胞・非心筋細胞相互作用の意義 : 非心筋細胞によるANP・BNP分泌調節とその機序の検討
原田 昌樹; 伊藤 裕; 中川 修; 小川 佳宏; 田村 尚久; 浜 典男; 宮本 恵宏; 石川 匡洋; 堀 義和; 桑原 宏一郎; 小川 恵美子; 谷口 泰代; 吉政 孝明; 桝田 出; 斉藤 能彦; 中尾 一和
Japanese circulation journal, 60(0), 426 - 426, 20 Feb. 1996, Not invited
Lead

Multiple Fistulae of Coronary Arteries to Both Ventricles
Kohei Shiota; Mika Kinoshita; Naritaka Kimura; Hideo Kurosu; Koichiro Ktjwahara; Chisato Mori
Japanese Heart Journal, 29(5), 741 - 746, 1988, Not invited
Lead

2021 - Present
日本循環器協会

2018 - Present
日本腫瘍循環器学会

2018 - Present
日本心血管インターベンション学会

2017 - Present
日本心臓リハビリテーション学会(

2016 - Present
日本肺高血圧・肺循環器学会

2014 - Present
日本抗加齢医学会

2013 - Present
日本生理学会

2012 - Present
国際心臓研究学会(ISHR)日本部会

2011 - Present
日本高血圧学会

2011 - Present
日本心エコー図学会

2006 - Present
日本心臓病学会

2006 - Present
日本不整脈心電学会

2006 - Present
日本糖尿病学会

2006 - Present
日本臨床分子医学会

2000 - Present
American Heart Association

1998 - Present
日本心不全学会

1998 - Present
日本心血管内分泌代謝学会

1995 - Present
日本内分泌学会

1994 - Present
日本循環器学会

1992 - Present
日本内科学会

心不全におけるBNP、ANP前駆体の分泌調節不全の機序解明と新規治療法の開発
科学研究費助成事業, 日本学術振興会, 基盤研究(C)
京都大学
01 Apr. 2022 - 31 Mar. 2025

肺動脈性肺高血圧症におけるTRPC6, CNP経路の研究
科学研究費助成事業, 日本学術振興会, 基盤研究(C)
京都大学
01 Apr. 2022 - 31 Mar. 2025

Elucidation of significance of saliva PRPs as a potential biomarker and therapeutic target for aging-associated cardiovascular and renal diseases
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
01 Apr. 2021 - 31 Mar. 2024

肺動脈性肺高血圧症に対する治療薬としての TRPC3/6阻害薬L862の有効性についての治験準備
難治性疾患実用化研究事業, 国立研究開発法人日本医療研究開発機構
2021 - Mar. 2024

Elucidation of transcriptional and epigenomic circuit ro reveal molecular mechanisms underlying heart failure and identify novel therapeutic targets
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
Shinshu University
01 Apr. 2020 - 31 Mar. 2023

Development of novel diagnostic and therapeutic methods for cardiac diseases based on the elucidation of the regulatory mechanism of glycosylation of proBNP
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Kyoto University
01 Apr. 2019 - 31 Mar. 2022

Potential significance of TRPC3/6 and CNP as novel therapeutic targets of pulmonary arterial hypertension
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Kyoto University
01 Apr. 2018 - 31 Mar. 2021

高齢心不全患者の多剤併用および薬剤性有害事象に関する診療実態調査
循環器疾患・糖尿病等生活習慣病対策実用化研究事業, 日本医療研究開発機構(AMED)
2018 - 2020

Elucidation of transcriptional and epigenomic regulation for maintaining normal cardiac function
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
Shinshu University
01 Apr. 2017 - 31 Mar. 2020

Long term follow-up of cardiac function and prognosis after optimal therapy in patients with systemic amyloidosis
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
01 Apr. 2017 - 31 Mar. 2020

Evaluation for regulatory mechanism of glycosylation and secretion of less bioactive proBNP by O-linked glycosylation
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Kyoto University
01 Apr. 2016 - 31 Mar. 2019

Investigation of the significance of MRTF-A, a co-activator of SRF, in the development of obesity that is an underlying risk factor for cardiovascular diseases
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research
Shinshu University
01 Apr. 2016 - 31 Mar. 2018

Blockade of TRPC6/3 is a Novel Therapeutic Approach Against Pulmonary Arterial Hypertension
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Kyoto University
01 Apr. 2015 - 31 Mar. 2018

Elucidation of the molecular mechanism and clinical application of increased plasma level of BNP precursor in patients with heart failure
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Kyoto University
01 Apr. 2015 - 31 Mar. 2018

Elucidation of epigenetic regulation of gene expresson involved in maintaining cardiac function and metabolism
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
01 Apr. 2014 - 31 Mar. 2017

Impact of exercise therapy on oxidative stress in patients with peripheral artery disease
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B)
Shinshu University
01 Apr. 2014 - 31 Mar. 2017

Elucidation of significance of vascular CNP-GC-B system in vascular integrity and pathology
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research
Kyoto University
01 Apr. 2014 - 31 Mar. 2016

Elucidation of pathophysiological significance of glycosylation in the regulatory mechanism of BNP processing
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Kyoto University
01 Apr. 2013 - 31 Mar. 2016

HCN4-luciferase knock-in mouse is a new tool for pacemaker cell reprogramming
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
Kurume University
01 Apr. 2012 - 31 Mar. 2016

Blockade of TRPC6/3 is a Novel Therapeutic Approach Against Pathological Cardiac Remodeling
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Kyoto University
01 Apr. 2012 - 31 Mar. 2015

Significance of reciprocal expression of myocardian and MRTF-A during the development of vascular disease
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research
Kyoto University
01 Apr. 2012 - 31 Mar. 2014

新規創薬を目指した生活習慣病・難治性疾患モデル遺伝子変異ラットの開発と解析
厚生労働科学研究費補助金(厚生科研費), 厚生労働省(MHLW)
厚生労働省研究事業
2012 - 2014

Elucidation of transcriptional and epigenomic regulation in the development of heart failure
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
Kyoto University
01 Apr. 2011 - 31 Mar. 2014

Translational research of circulation-regulated peptide using B-type natriuretic peptide and adrenomedullin
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Kyoto University
2011 - 2013

新規カルシウムチャネルTRPC3/6イオンチャネルを標的とした新規心血管病治療薬の開発
産学が連携した研究開発成果の展開 研究成果展開事業 研究成果最適展開支援プログラム(A-STEP) 探索タイプ
京都大学
2011 - 2012

Elucidation of significance of TRPM2 in progression of heart failure
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Kyoto University
2010 - 2012

Physiological Function of Hormones Derived from Mesenchymal Cells and Its Failure
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (S)
Kyoto University
11 May 2009 - 31 Mar. 2014

新規遺伝子変異ラット作製技術に基づく生活習慣病・難治性疾患モデルラットの開発
厚生労働科学研究費補助金(厚生科研費), 生労働省(MHLW)
厚生労働省研究事業
2009 - 2011

Elucidation of molecular mechanisms regulating the gene expression of fetal cardiac ion channels and its implication as a novel therapeutic target for the treatment of heart failure
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
Kyoto University
2008 - 2010

Crosstalk between NRSF-NRSE system and PPAR system contributing to the homeostasis of cardiac myocyte function
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Kyoto University
2007 - 2008

ヒストンアセチル化酵素の心筋ミトコンドリア形成と細胞生存維持における役割の解明
科学研究費助成事業, 日本学術振興会, 萌芽研究
京都大学
2006 - 2006

心筋細胞の最終分化に関わる転写調節機構の解明
科学研究費助成事業, 日本学術振興会, 特別研究員奨励費
京都大学
2000 - 2002

Journal of Asian Pacific Society of Cardiology, Editorial Board
Peer review
2022 - Present

Journal of Cardiology, Associate Editor
2022 - Present

Circulation Journal, Associate Editor
2021 - Present

Journal of Cardiac Failure, Associated Editor
2021 - Present

Peptides, Editorial Advisory Board
Peer review
2020 - Present

Internal Medicine, Associate Editor
Peer review
2019 - 2023

Circulation Reports, Associate Editor
2018 - Present

Journal of Cardiology Cases, Associate Editor
2016 - 2022

Circulation Journal, Editorial Board
Peer review
2016 - 2021

International Heart Journal, Editorial Board
Peer review
2015 - Present