OHHASHI TOSHIO
School of Medicine Innovation of Medical and Health Sciences Research
Professor
Researcher Information
Mail Address
- ohhashi★shinshu-u.ac.jp
Career
- 2003 - 2008
Shinshu Univ. Sch. of Med. Dean - 2001
Shinshu Univ. Council - 2000
SKINOS Co. Ltd. Director(tentative) - 2000
Shinshu Univ. Gradate Sch. of Med. Professor - 1985
Shinshu Univ. Sch. of Med. Professor - 1980
Shinshu Univ. Sch. of Med. Associate Professor - 1979 - 1981
Queen's Univ. of Belfast Assistant Professor - 1977
ShinshuUniv. Sch. of Med. Assistant Professor - 1974
Shinshu Univ. Sch. of Med. Research Associate
Research activity information
Paper
- Heatstroke risk informing system using wearable perspiration ratemeter on users undergoing physical exercise. Scientific Reports
Momose H, Takasaka M, Watanabe-Asaka T, Hayashi M, Maejima D, Kawai Y, Ohhashi T
SCIENTIFIC REPORTS, 13(1), 416, 2023 - Cell surface ATP synthase-released H + and ATP plays key roles in cocoa butter intake-mediated regulation of gut immunity through releases of cytokines in rat.
Arai N, Kajihara R, Takasaka M, Amari K, Kuneshita N, Maejima D, Watanabe-Asaka T, Hayashi M, Yokoyama Y, Kaidoh M, Kawai Y, Ohhasi T
Pfllug Arch Eur J Phy, 475(8), 945-960, 2023 - Physiological roles of lymph flow-mediated nitric oxide in lymphatic system.
Ohhashi T, Kawai Y, Maejima D, Hayashi M, Watanabe-Asaka T
Lymphatic Res Biol, 21(3), 253-261, 2023 - Estimation of the lymph flow through thoracic duct in human subjects using the urine osmolarity: applicable for evaluating the effectiveness of manual lymph drainage.
Ohhashi T, Kawai Y, Hayashi M, Watanabe-Asaka T
Lymphatic Res Biol, 20(3), 282-289, 2022 - Portal blood flow-dependent NO-mediated lymph formation in rat jejunum.
Amari K, Kajihara R, Arai N, Hayashi M, Watanabe-Asaka T, Kaidoh M, Yokoyama Y, Ajima K, Maejima D, Kawai Y, Ohhashi T
Pfllug Arch Eur J Phy, 474(5), 541-551, 2022 - From digestion and absorption to innate immunity and health care: water and food intake may contribute to IL-22 in ILC3-dependent mucosal immunity in the jejunum.
Watanabe-Asaka T, Hayashi M, Maejima D, Kawai Y, Ohhashi T
J Physiol Sci, 71(1), doi: 10.1186/s12576-021-00817-x, 2021, 2021 - Another route of CO2 gas excretion independent of red blood cells in human lungs.
Ide S, Arai N, Morimitsu N, Momose H, Hayashi M, Watanabe-Asaka T, Ishida T, Tanaka S, Seto T, Kawai Y, Kawamata M, Ohhashi T
Pfllug Arch Eur J Phy, 473(10), 1657-1666, 2021 - Water intake releases serotonin from enterochromaffin cells in rat jejunal villi.
Kajihara R, Amari K, Arai N, Nagashio S, Hayashi M, Watanabe-Asaka T, Kaidoh M, Yokoyama Y, Maejima D, Kawai Y, Ohhashi T
Pfllug Arch Eur J Phy, 473(6), 921-936, 2021 - Water intake accelerates ATP release from myofibroblast cells in rats: ATP-mediated podoplanin-dependent control for physiological function and immunity.
Hayashi M, Watanabe-Asaka T, Nagashio S, Kaidoh M, Yokoyama Y, Maejima D, Kajihara R, Amari K, Arai N, Kawai Y, Ohhashi T
Am J Physiol Gastrointest Liver Physiol, 320(1), G54-G65, 2021 - Evaluating Lymph Flow through the Thoracic Duct using Urine Osmolarity in Human Subjects.
Hayashi M, Watanabe-Asaka T, Maejima D, Nagashio S, Kajihara R, Amari K, Yokoyama Y, Kaidoh M, Sugano M, Honda T, Kawai Y, Ohhashi T
Lymphatic Res Biol, 18(4), 351-356, 2020 - Water intake increases mesenteric lymph flow and the total flux of albumin, long-chain fatty acids, and IL-22 in rats: New concept of absorption in jejunum.
Nagashio S, Ajima K, Maejima D, Sanjo H, Kajihara R, Hayashi M, Watanabe-Asaka T, Kaidoh M, Yokoyama Y, Taki S, Kawai Y, Ohhashi T
Am J Physiol Gastrointestinal and Liver Physiology, 316, G155-G165, 2019 - CO2 gas exchange in lungs.
Ohhashi T, Kawai Y
Lungs and Brething, 2(3), 1, 2018 - Lymph drainage from the chylocyst-induced hemodilution in an in vivo rabbit study.
Ajima K, Kawai Y, Maejima D, Suzuki S, Yano S, Hayashi M, Katsumata A, kaidoh M, Yokoyama Y, Ohhashi T
Lymatic Res Biol, 16(2), 154-159, 2018 - Proposed new lymphology combined with lymphatic physiology, innate immunology, and oncology(Review).
Ohhashi T, Kawai Y
J Physiol Sci., 65(1), 51-66, 2015 - Abdominal respiration induces hemodilution and related reduction of blood.
Kawai Y, Ajima K, Nagai T, Yokoyama Y, Kaidoh M, Seto E, Honda T, Ohhashi T.
Lymphat Res Biol., 13(3), 202-207, 2015 - In vivo support for the new concept of pulmonary blood flow-mediated CO2 gas excretion in the lungs.
Kawai Y, Ajima K, Kaidoh M, Sakaguchi M, Tanaka S, Kawamata M, Kimura H, Ohhanshi T
Am J Physiol., 308(12), L1224-L1236, 2015 - Pivotal roles of lymphatic endothelial cell layers in the permeability to hydrophilic substances through collecting lymph vessel walls: Effects of inflammatory cytokines.
Kawai Y, Kaidoh M, Yokoyama Y, Ohhashi T
Lymphat Res Biol, 12(3), 124-135, 2014 - New lymphology combined with lymphatic physiology, innate immunology, and oncology.
Ohhashi T, Kawai Y
J Blood & Lymph., 4, 126, 2014
- Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis.
Hosaka K, Yang Y, Seki T, Nakamura M, Andersson P, Rouhi P, Yang X, Jensen L, Lim S, Feng N, Xue Y, Li X, Larsson O, Ohhashi T, Cao Y
Nat. Comm., 4, 2129, 2013 - Sphingosine 1-phosphate (S1P) induces S1P2 receptor-dependent tonic contraction in murine iliac lymph vessels.
Kimizuka K, Kawai Y, Maejima D, Ajima K, Kaidoh M, Ohhashi T
Microcirculation, 20(1), 1-16, 2013 - Cell surface F1/FO ATP synthase contributes to interstitial flow-mediated development of the acidic microenvironment in tumor tissues.
Kawai Y, Kaidoh M, Yokoyama Y, Ohhashi T
Am. J. Physiol. Cell Physiol., 305(11), C1139-1150, 2013 - New concept of flow-mediated CO2 gas excretion from human pulmonary arteriolar endothelial cells.
Kawai Y, Ohhashi T
J. Physiol. Sci., 63(1), S219, 2013 - Pivotal roles of shear stress in the microenvironmental changes that occur within sentinel lymph nodes
Kawai, Y; Kaidoh, M; Yokoyama, Y; Ohhashi, T
CANCER SCIENCE, 103(7), 1245-1252, Jul. 2012
- Shear stress-mediated F1/FO ATP synthase-dependent CO2 gas excretion from human pulmonary arteriolar endothelial cells.
Kawai Y, Yoshida K, Kaidoh M, Yokoyama Y, Ohhashi T.
J Cell Physiol., 227(5), 2059-2068, 2012 - The establishment of new lympholgy: overview
Ohhashi, T
Annals of Vascular Diseases, 5(3), 247-248, 2012 - Platelet-derived growth factor (PDGF)-BB produces NO-mediated relaxation and PDGF receptor β-dependent tonic contraction in murine iliac lymph vessels.
Maejima D, Kawai Y, Ajima K, Ohhashi T.
Microcirculation, 18(6), 474-486, 2011 - Real-time imaging of the lymphatic channels and sentinel lymph nodes of the stomach using contrast-enhanced ultrasonography with Sonazoid in a porcine model.
Kawai Y, Ajima K, Nagai T, Kaidoh M, Ohhashi T.
Cancer Sci., 102(11), 2073-2081, 2011 - Shear stress-induced ATP-mediated endothelial constitutive nitric oxide synthase expression in human lymphatic endothelial cells.
Kawai Y, Yokoyama Y, Kaidoh M, Ohhashi T.
Am J Physiol Cell Physiol, 298(3), C647-C655, 2010 - Topics of physiological and pathophysiological functions of lymphatics.
Kawai Y, Ohhashi T.
Curr Mol Med, 9(8), 942-953, 2009 - Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells.
Song H, Suehiro J, Kanki Y, Kawai Y, Inoue K, Daida H, Yano K, Ohhashi T, Oettgen P, Aird WC, Kodama T, Minami T.
J Biol Chem, 284(42), 29109-29124, 2009 - Chemokine CCL2 facilitates ICAM-1-mediated interactions of cancer cells and lymphatic endothelial cells in sentinel lymph nodes.
Kawai Y, Kaidoh M, Yokoyama Y, Sano K, Ohhashi T.
Cancer Sci, 100(3), 419-428, 2009 - Critical roles of VEGF-C-VEGF receptor 3 in reconnection of the collecting lymph vessels in mice.
Ikomi F, Kawai Y, Nakayama J, Ogiwara N, Sasaki K, Mizuno R, Ohhashi T.
Microcirculation, 15(7), 591-603, 2008 - Head-down tilt posture elicits transient lymphocyte mobilization from the iliac, but not mesenteric, lymph nodes of rats.
Suzuki S, Mizuno R, Ikomi F, Ohhashi T.
J Appl Physiol, 105(5), 1595-1601, 2008 - MDA-MB-231 produces ATP-mediated ICAM-1-dependent facilitation of the attachment of carcinoma cells to human lymphatic endothelial cells.
Kawai Y, Kaidoh M, Ohhashi T.
Am J Physiol Cell Physiol, 295(5), C1123-C1132, 2008 - Glucose and glucose transporters regulate lymphatic pump activity through activation of the mitochondrial ATP-sensitive K+ channel.
Li X, Mizuno R, Ono N, Ohhashi T.
J Physiol Sci, 58(4), 249-261, 2008 - NT-702, a selective phosphodiesterase 3 inhibitor, dilates rabbit spinal arterioles via endothelium-dependent and endothelium-independent mechanisms.
Mizuno R, Watanabe S, Ohhashi T.
J Physiol Sci, 58(4), 229-237, 2008 - Heterogeneity in immunohistochemical, genomic, and biological properties of human lymphatic endothelial cells between initial and collecting lymph vessels.
Kawai Y, Hosaka K, Kaidoh M, Minami T, Kodama T, Ohhashi T.
Lymphat Res Biol, 6(1), 15-27, 2008 - In situ lymph dynamic characterization through lymph nodes in rabbit hind leg: special reference to nodal inflammation.
Nagai T, Ikomi F, Suzuki S, Ohhashi T.
J Physiol Sci, 58(2), 123-132, 2008 - Significance of tumor-associated stroma in promotion of intratumoral lymphangiogenesis: pivotal role of a hyaluronan-rich tumor microenvironment.
Koyama H, Kobayashi N, Harada M, Takeoka M, Kawai Y, Sano K, Fujimori M, Amano J, Ohhashi T, Kannagi R, Kimata K, Taniguchi S, Itano N.
Am J Pathol, 172(1), 179-193, 2008 - High oxygen tension constricts epineurial arterioles of the rat sciatic nerve via reactive oxygen species.
Sakai N, Mizuno R, Ono N, Kato H, Ohhashi T.
Am J Physiol Heart Circ Physiol, 293(3), H1498-H1507, 2007 - Immunohistochemical demonstration of proliferating lymphatic vessels in colorectal carcinoma and its clinicopathological significance.
Omachi T, Kawai Y, Mizuno R, Nomiyama T, Miyagawa S, Ohhashi T, Nakayama J.
Cancer Lett, 246(1-2), 167-172, 2007 - Characterization and microarray analysis of genes in human lymphatic endothelial cells from patients with breast cancer.
Kawai, Y; Minami, T; Fujimori, M; Hosaka, K; Mizuno, R; Ikomi, F; Kodama, T; Ohhashi, T
Lymphat Res Biol, 5(2), 115-126, 2007
MISC
Books and other publications
- リンパを流すと健康になる
大橋俊夫
PHP研究所, 2010Encyclopedia of Neuroscience Part19
Ohhashi T, Kawai Y, Sweat gland control
Springer, 3911-3914 2009Lectures, oral presentations, etc.
- Water intake accelerates mesenteric lymph flow and the total flux of long-chain fatty acids in rats.
Ohhashi T, Kawai Y
Lymphatic Forum 2019, May 2019Research Themes
- 消化器癌転移時のセンチネルリンパ節微小環境変化を可視化評価するための基礎研究
科学研究費補助金, 挑戦的萌芽研究
2012 - 2013 - 臨床的応用に視点を置いたリンパ行性微小癌転移機構解明の体系的研究
科学研究費補助金, 基盤研究（Ａ）
2010 - 2013 - 内視鏡的超音波イメージングによるセンチネルリンパ節可視化及び転移診断技術の開発
受託研究, 経済産業省インテリジェント手術機器開発事業
2007 - 2011 - リンパ行性微小癌転移機構解明のためのリンパ学を基盤とした体系的研究
科学研究費補助金, 基盤研究(A)
2007 - 2010 - 消化管免疫特性に対する重力変動の影響
受託研究, 財団法人日本宇宙フォーラム
2006 - 2007 - センチネルリンパ節に特異的に発現する分子プロファイリングの探査とその臨床研究
受託研究, 産学共同シーズイノベーション化事業顕在化ステージ
2006 - 2007 - 前哨リンパ節（ＳＬＮ）への癌転移因子解析のリンパ学的研究
科学研究費補助金, 萌芽研究
2005 - 2006 - リンパ節循環動態に関する重力変動の影響
受託研究, 財団法人日本宇宙フォーラム
2005 - 2006 - 平成16年度地域新生コンソーシアム研究開発事業 乳ガン・消化器ガンの低侵襲治療を可能とする診断システムの開発
受託研究, 経済産業省関東経済産業局
2004 - 2005 - 前哨リンパ節への癌転移因子解明のリンパ生理学的研究
科学研究費補助金, 萌芽研究
2003 - 2004 - Perspiration Research: Basic andClinical
1980 - Developmental studies of new appratus and machines to evaluate condition of metal or physical health in human beings
1974 - Pathophysiological studies of lymphatic system with special reference to metastases of carcinoma cells
1974 - Functional and morphological studies of arterioles
1974
