Nishii Yoshinori
Academic Assembly School of Science and Technology Institute of Textile Science and Technology
Faculty of Textile Science and Technology Division of Chemistry and Materials
Professor
Researcher Information
Field Of Study
- Structural organic chemistry and physical organic chemistry, Organic Chemistry
- Structural organic chemistry and physical organic chemistry, cyclopropane chemistry
- Structural organic chemistry and physical organic chemistry, Organic synthesis
- Structural organic chemistry and physical organic chemistry, Natural product organic chemistry
Web site
Career
- 2018
 Professor
- 2007 - 2018
 Associate Professor
- 2003 - 2007
 Shinshu University Assistant Prof.
- 2002 - 2003
 Kwansei Gakuin University Postdoctoral Fellow
- 2000 - 2002
 Institute of Physical and Chemical Research (RIKEN) Special Postdoctoral Fellow
- 1998 - 2000
 University of Pittsburgh Postdoctoral Fellow
- 1997 - 1999
 Japan Society for Promotion of Science Special Research Fellow
Research activity information
Award
Paper
- Asymmetric Total Synthesis of a Bioactive Lignanamide Using a 5-endo-tet-type Cyclization of Activated Cyclopropylcarbinols and Synthetic Support for the Reaction Mechanism
 Taichi Saito, Kazuki Shibata, Ryohei Takagi, Yuka Shimizu, Naoya Takaki, and Yoshinori Nishii*
 Eur. J. Org. Chem., e202200563, 2022, Refereed
 Corresponding 
- Asymmetric total synthesis of four bioactive lignans using donor–acceptor cyclopropanes and bioassay of (-)- and (+)-niranthin against hepatitis B and influenza viruses
 Ryotaro Ota, Daichi Karasawa, Mizuki Oshima, Koichi Watashi, Noriko Shimasaki, and Yoshinori Nishii*
 RSC Advances, 12, 4635-4639, 2022, Refereed, Not invited
 Corresponding 
- From Enantioenriched Donor–Acceptor Cyclopropylcarbinols to Axially Chiral Arylnaphthalenes via Aryldihydronaphthalenes: Central-to-Axial Chirality Exchange
 Taichi Saito, Yuka Shimizu, Yusuke Araki, Yoshino Ohgami, Yu Kitazawa, Yoshinori Nishii*
 Eur. J. Org. Chem., e202101213, 2022, Refereed
 Corresponding 
- ドナー・アクセプター置換シクロプロパンの環開裂を伴う分子内環化と分子間付加:SN1およびSN2機構を利用する高立体選択的合成
 西井良典
 有機合成化学協会誌, 76(9), 922-937, 2018, Refereed
- ポドフィリックアルデヒドの全合成における中間体の反応性の計算化学的考察
 三原陽子, 森川大*, 野村泰志, 西井良典
 J. Comput. Chem. Jpn., 16(4), 102-105, 2017, Refereed
- A formal homo-Nazarov cyclization of enantioenriched donor-acceptor cyclopropanes and following transformations: asymmetric synthesis of multi-substituted dihydronaphthalenes
 Seijiro Takada, Naoya Takaki, Kenta Yamada, and Yoshinori Nishii*
 Org. Biomol. Chem., 15, 2443-2449, 2017
- Stereochemical courses and mechanisms of ring-opening cyclization of donor-acceptor cyclopropylcarbinols and cyclization of 7-benzyloxy dibenzyl lignan lactones
 Takada, seijiro; Sasazawa, Kazuya; Yubune, Toshihide; Takaki, Naoya; Ota, Ryotaro; Nishii, Yoshinori*
 Chem. Lett., 46, 524-527, 2017, Refereed 
- Stereoselective oxy-homo-Michael reactions of enantioenriched bicyclic donor–acceptor cyclopropanes to afford optically active trans-α,β-disubstituted γ-butyrolactones possessing three serial chiral centers
 Seijiro Takada, Kiitsu Iwata, Toshihide Yubune, and Yoshinori Nishii*
 Tetrahedron Lett., 57, 2422-2425, 2016, Refereed
- Cu-catalyzed 1,5-addition of Grignard reagents to enantioenriched donor-acceptor cyclopropanes with inversion
 S. Takada, T. Saito, K. Iwata, Y. Nishii*
 Asian J. Org. Chem., 5, 1225-1229, 2016, Refereed
- First Total Synthesis of(+)-Podophyllic Aldehydes
 Junki Ito, Daichi Sakuma, and Yoshinori Nishii*
 Chem. Lett., 44, 297-299 (open access article), 2015, Refereed
- 多置換シクロプロパンの高立体選択的合成と不斉伝搬環拡大反応
 西井良典
 有機合成化学協会誌, 73(7), 701-712, 2015, Refereed
- Highly Stereoselective C-C Bond-Forming Reactions on Cyclopropane Rings using 1-(Methoxycarbonyl)cyclopropylzinc bromides
 D. Sakuma, K. Yamada, K. Sasazawa and Y. Nishii*
 Chem. Lett., 44, 818-820 (open access), 2015, Refereed
- Total Synthesis of (±)-Cyclogalgravin and its Dicarboxyl Analog Using Sc(OTf)3-Mediated Highly Diastereoselective Ring Expansion of 1-(Arylhydroxymethyl)cyclopropanecarboxylates
 Daichi Sakuma, Junki Ito, Ryo Sakai, Ryota Taguchi, Yoshinori Nishii*
 Chem. Lett., 43, 610-611 (open access article), 2014, Refereed
- Chemiluminescence of 9-benzylidene-10-methylacridans with electron-donating groups by chemically generated singlet oxygen- Application to metal ion sensing usingazacrowned compound
 J. Motoyoshiya, T. Tanaka, M. Kuroe, Y. Nishii.
 Bioluminescence and Chemiluminescence, 237-240, 2009
- First total synthesis of theopederin B
 Y. Nishii, T. Higa, S. Takahashi, T. Nakata
 Tetrahedron Lett., 50, 3597-3600, 2009
- Chemiluminescence of 4-styrylphthalhydrazides with crown etheras ionophore
 J. Motoyoshiya, M. Hotta, Y. Nishii, H. Aoyama
 Luminescence, 23, 37-41, 2008
- Practical, general, and systematic method for optical resolution of gem-dihalo- and monohalo cyclopropanecarboxylic acids utilizing chiral 1,1’-binaphtholmonomethyl ethers: Application to the synthesis of three chiral pesticides
 H. Yasukochi, T. Atago, A. Tanaka, H. Nakatsuji, E. Yoshida, A. Kakehi, Y. Nishii, Y. Yanabe
 Org. Biomol. Chem., 6, 540-547, 2008
- SmI2-Promoted Reformatsky-Type Reaction and Acylation of Alkyl 1-Chlorocyclopropancarboxylates
 T. Nagano, J. Motoyoshiya, A. Kakehi, Y. Nishii*
 Org. Lett., 10, 5453-5456, 2008
- Fluorescence quenching of versatile fluorescent probes based on strongly electron-donating distyrylbenzenes responsive to aromatic chlorinated and nitro compounds, boronic acid and Ca2+
 J. Motoyoshiya, Z. Fengqiang, Y. Nishii, H. Aoyama
 Spectrochimica Acta part A:, 69, 167-173, 2008
- Synthesis of Unsymmetrically and Highly Substituted Thiophenes Utilizing Regioselective Ring-expansion of gem-Dichlorocyclopropyl Ketones with Lawesson's Reagent
 Takao Nagano, Hiroki Kimoto, Hidefumi Nakatsuji, Jiro Motoyoshiya, Hiromu Aoyama, Yoo Tanabe,* Yoshinori Nishii*
 Chem. Lett., 36(1), 62-63, 2007
- Highly Stereoselective Radical Carbonylations of gem-Dihalocyclopropnane Derivatives with CO
 Yoshinori Nishii*, Takao Nagano, Hideki Gotoh, Ryohei Nagase, Jiro Motoyoshiya, Hiromu Aoyama, Yoo Tanabe*
 Org. Lett., 9, 563-566, 2007
- Synthesis of Hypericin via Emodin Anthrone Derived from a Two-fold Diels-Alder Reaction of 1,4-Benzoquinone
 J. Motoyoshiya, Y. Masue, Y. Nishi, H. Aoyama
 Natural Prod. Commun., 2, 67-70, 2007
- A 1,4-distyrylbenzene Bearing Donor-Acceptor Substituent as a fluorescence Probe Responsive to Protic Solvents
 J. Motoyoshiya, T. Yokozeki, Z. Fengqiang, Y. Nishii, H. Aoyama
 ITE Letters, 7, 593-596, 2006
- Different photochemical behavior of bis(biphenyl)ethylenes and ethenes in solution and in the solid-state: Structurally controlled Z/E-photoisomerization in the solid-state
 Zhu, FQ; Motoyoshiya, J; Nishii, Y; Aoyama, H; Kakehi, A; Shiro, M
 JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 184(1-2), 44-49, 2006   
- Synthesis of 4-Styrylphthalhydrazides and Their Chemiluminescence Reaction. Emitters and Chemiluminescence Efficiency Highly Dependent on Electronic Nature of Styryl Goups
 Jiro Motoyoshiya, Kazuya Yokota, Takuro Fukami, Shoji Konno, AyaYamamoto, Masanori Hotta, Ryu Koike, Sachiko Yoshioka, Yoshinori Nishii, and Hiromu Aoyama
 J. Heterocyclic Chem., 42, 1063-1068, 2005, Refereed
- Regiocontrolled benzannulation of diaryl (gem-dichlorocyclopropyl)methanols for the synthesis of unsymmetrically substituted alpha-arylnaphthalenes: Application to total synthesis of natural lignan lactones
 Nishii, Y; Yoshida, T; Asano, H; Wakasugi, K; Morita, J; Aso, Y; Yoshida, E; Motoyoshiya, J; Aoyama, H; Tanabe, Y
 JOURNAL OF ORGANIC CHEMISTRY, 70(7), 2667-2678, 2005 
- Poly(benzyl ether) dendrimers with strongly fluorescent distyrylbenzene cores as the fluorophores for peroxyoxalate chemiluminescence: insulating effect of dendritic structures on fluorescent sites
 Koike, R; Katayose, Y; Ohta, A; Motoyoshiya, J; Nishii, Y; Aoyama, H
 Tetrahedron, 61(46), 11020-11026, 2005   
- エステル化・スルホニル化・アミド化・シリル化:汎用反応の実用的合理化
 田辺陽,御前智則,飯田聖,西井良典
 有機合成化学協会誌, 62, 1249-1259, Dec. 2004
- 中心不斉から軸不斉への転写と変換
 西井良典
 化学と工業, 57, 1212, Nov. 2004
- A Facile Synthesis of the Angucyclinone Antibiotic (+)-Rubiginone B2 Involving the BF3-Mediated Diels-Alder Reaction of Juglone
 Jiro Motoyoshiya, Yusuke Masue, Gento Iwayama, Sachiko Yoshioka, Yoshinori Nishii, and Hiromu Aoyama
 Synthesis, 2099-2102, 2004
- Chemiluminescent Autoxidation of alpha-Silyl Carbanios Derived From 9-Silyl-10-Methylacridanes
 Jiro Motoyoshiya, Kunihiko Tokutake, Motoki Kuroe, Sachiko Yoshioka, Yoshinori Nishii, and Hiromu Aoyama
 Heterocycles, 1667-1672, 2004
- Chirality Exchange from sp3 Central Chirality to Axial Chirality: Benzannulation of Optically Active Diaryl-2,2-dichlorocyclopropylmethanols to Axially Chiral alpha-Arylnaphthalenes
 Yoshinori Nishii, Kazunori Wakasugi, Keisuke Koga, Yoo Tanabe
 J. Am. Chem. Soc., 126, 5358-5359, 2004
- Simple, Mild, and Practical Esterification, Thioesterification, and Amide Formation Utilizing p-Toluenesulfonyl Chloride and N-Methylimidazole
 K. Wakasugi, Akira Iida, T. Misaki, Y. Nishii, Y. Tanabe
 Adv. Synth. Catal., 345, 1209-1214, 2003
- Reactions of 9-Phosphorylacridines with Aqueous Hydrogen Peroxide Accompained by Weak Chemiluminescence: Remarkable Substituent Effect on Emission Efficiency
 Jiro Motoyoshiya, Rie Shima, Yutaka Takaguchi, Yoshinori Nishii, and Hiromu Aoyama
 Heterocycles, 60, 2543-2549, 2003
- Practical Short-step Synthesis of 1b?Methylcarbapenem Utilizing a New Dehydration Ti-Dieckmann Condensation
 Y. Tanabe, N. Manta, R. Nagase, T. Misaki, Y. Nishii, M. Sunagawa, and A. Sasaki
 Adv. Synth. Catal., 345, 967-970, 2003
- Novel and efficient method for esterification, amidation between carboxylic acids and equimolar amounts of alcohols, and amines utilizing Me2NSO2Cl and N,N-dimethylamines; Its application to the synthesis of coumaperine, a natural chemopreventivedieneamide
 K. Wakasugi, A. Nakamura, A. Iida, Y. Nishii, N. Nakatani, S. Fukushima, and Y. Tanabe
 Tetrahedron, 59, 5337-5345, 2003
- Silazanes / catalytic bases: Mild, powerful and chemoselective agents for the preparation of enol silyl ethers from ketones and aldehydes
 Yoo Tanabe, T. Misaki, M. Kurihara, A. Iida, and Y. Nishii
 Chem. Commn., 1628, 2002
- Total synthesis of pederin, an insect toxin: an efficient synthesis of the right half, (+)-benzoylpedamide
 T. Takemura, Y. Nishii, S Takahasi, J. Kobayashi, and T. Nakata
 Tetrahedron (Symposium-in-print), 58, 6359, 2002
- Direct, Practical, and Powerful Crossed Aldol Additions between Ketones and Ketones or Aldehydes Utilizing Environmentally Benign TiCl4 - Bu3N Reagent
 Y. Tanabe, N. Matsumoto, T. Higashi, T. Misaki, T. Itoh, M. Yamamoto, K. Mitarai, and Y. Nishii
 Tetrahedron (Symposium-in-print), 58, 8269, 2002
- Efficient One-step Synthesis of Trialkylsubstituted 2(5H)-Furanone Utilizing Direct Ti-Crossed Aldol Condensation and Its Application to the Straightforward Synthesis of (R)-Mintlactone and (R)-Menthofuran
 Y. Tanabe, K. Mitarai, T. Higashi, T. Misaki and Y. Nishii
 Chem. Commun., 2542-2545, 2002
- Stereoselective Bifurcating-type Radical Cyclization of gem-Dibromocyclopropanes for the Synthesis of Uniquely Fused 5-3-5-Type Tricyclic Compounds
 Y. Nishii, A. Fujiwara, K. Wakasugi, K. Yanagi, M. Miki, and Y. Tanabe
 Chem. Lett., 30-31, 2002
- Synthesis and Stereostructure-Activity Relationship of Three Asymmetric Center Pyrethroids: 2-Methyl-3-phenylcyclopropyl-methyl 3-Phenoxybenzyl Ether and Cyanohydrin Ester
 Y. Nishii, N. Maruyama, K. Wakasugi and Y. Tanabe
 Bioorg. Med. Chem., 9, 33, 2001
- ピレスロイド殺虫剤:ミステリアスな立体構造活性相関
 田辺 陽・西井良典
 化学と生物, 39, 782, 2001
- Cyclopropane-shift type reaction of diaryl(2-halogenocyclopropyl)methanols promoted by Lewis acids
 K. Wakasugi, Y. Nishii, and Y. Tanabe
 Tetrahedron Lett., 41, 5937, 2000
- gem-ジハロシクロプロパンの特徴を生かした反応と合成:カチオン的ベンズアヌレーション
 田辺 陽, 西井 良典
 有機合成化学協会誌, 57, 170-180, 1999
- Does the Facile Reductive Rearrangement of 2-Allyloxycyclohexenone with Bu3SnH Occur by a Radical-Accelerated Claisen Rearrangement or an Stannyloxy-Accelerated Claisen Rearrangement?
 D. P. Curran and Y. Nishii
 J. Am. Chem. Soc., 121, 8955-8956, 1999
- Dimethylation and Hydrodechlorination of gem-Dihalocyclopropaneswith Grignard Reagents Promoted by Fe(III) or Co(II) Catalysts
 Y. Nishii, K. Wakasugi, and Y. Tanabe
 Synlett, 67-69, 1998
- Enantiomeric Resolution of a Germacrene-D Derivative by Chiral High-performance Liquid Chromatography
 Y. Nishii, T. Yoshida, and Y. Tanabe
 Biosci. Biotech. Biochem, 61, 547, 1997
- Total Synthesis of (-)-Periplanones C and D. Their Pheromonal Activities against Three Periplaneta Species
 Y. Nishii, K. Watanabe, T. Yoshida, T. Okayama, S. Takahashi, and Y. Tanabe
 Tetrahedron, 53, 7209, 1997
- Regiocontrolled Benzannulation of Diaryl(gem-dichlorocyclopropyl)methanols for the Synthesis of "Unsymmetrically" Substituted a-Arylnaphthalenes
 Y. Nishii, T. Yoshida, and Y. Tanabe
 Tetrahedron Lett., 38, 7195-7198, 1997
- Sequential and Regioselective Friedel-Crafts Reactions of gem-Dihalocyclopropanecarbonyl Chlorides with Benzenes for the Synthesis of 4-Aryl-1-naphthol Derivatives
 Y. Nishii and Y. Tanabe
 J. Chem. Soc., Perkin Trans. 1, 477-486, 1997
- Regioselective Cyclocondensation of Chlorocarbonylsulfenyl Chloride with Hydrazones: Efective Synthesis of a Class of Sulfur and Nitrogen Containing Heterocycles with -COS- Linkage
 Y. Tanabe, K. Mori, and Y. Nishii
 Heterocycles, 43, 141, 1996
- Synthesis of 2,5-Diaryl-3-halofurans via Regioselective Ring Cleavage of 2-Aryl-3,3-dihalocyclopropyl Aryl Ketones
 Y, Tanabe, K. Wakimura, Y, Nishii, and Y, Muroya
 Synthesis, 338, 1996
- Novel Method for the Synthesis of a- and b-Halonaphthalenes via Regioselective Ring Cleavage of Aryl (gem-dihalocyclopropyl)methanols. Application to Total Synthesis of Lignan Lactones, Justicidin E and Taiwanin C
 Y. Tanabe, S. Seko, Y. Nishii, T. Yoshida, N, Utsumi, and G, Suzukamo
 J. Chem. Soc., Perkin Trans. 1, 2157, 1996
- Sequential and Highly Stereoselective Intermolecular Radical Additions of 2,3-cis-Disubstituted 1,1-Dibromo- and 1-Bromocyclopropanes to Electron-Deficient Olefins
 Y. Tanabe, K. Wakimura and Y. Nishii
 Tetrahedron Lett., 37, 1837-1840, 1996
- Synthesis and Stereostructure-activity Relationship of a Synthetic pyrethroid, 2-Chloro-1-methyl-3-phenylcyclopropylmethyl 3-Phenoxybenzyl Ether
 Y. Nishii, K. Wakimura, T. Tsuchiya, S. Nakamura and Y. Tanabe
 J. Chem. Soc., Perkin Trans. 1, 1243-1249, 1996
- Sequential and Regioselective Friedel-Crafts Reaction of gem-Dihalocyclopropanecarbonyl Chlorides with Benzenes for the Synthesis of 4-Aryl-1-naphthol Derivatives
 Y. Nishii and Y. Tanabe
 Tetrahedron Lett., 36, 8803-8806, 1995
- Synthesis of Perhydoro-1,3,4-thiadiazin-5-ones and 3-Arylaminothiazolidin-4-ones by the Regioselective Cyclocondensation of 2-Sulfanylalkanoic Acids or Their Silyl Esters with Methyl and Aryl hydrazones
 Y. Tanabe, M. Nagaosa, Y. Nishii, and Y, Muroya
 Heterocycles, 41, 2033, 1995
- Synthetic Pyrethroid Containing Halocyclopropane Structure
 Y. Nishii, H. Matsumura,Y. Muroya, T. Tsuchiya, Y. Tanabe
 Biosci. Biotech. Biochem., 59, 1335-1336, 1995
- A Novel and Regioselective Radical Cyclization of gem- Dihalocyclopropyl Substituted Alkenes and Alkynes
 Y. Tanabe, Y. Nishii, and K. Wakimura,
 Chem. Lett., 1757-1760, 1994
Lectures, oral presentations, etc.
- シクロプロパンの特性を生かした高選択的合成法の開発と生理活性物質合成への応用
 西井良典
 第27回農薬デザイン研究会, 2012Organic synthesis of biologically active compounds toward the chemical protection of textile
 Yoshinori NISHII, Ryo SAKAI, Eri YOSHIDA, Yoo TANABE
 2nd Asian Protective Clothing Conference, 2011, InvitedSynthetic Studies utilizing Cyclopropanes,
 Y. Nishii
 3rd International Symposium on High-Tech Fiber Engineering 2009, 2009, InvitedSmI2-Promoted Reformatsky-Type Reaction of Alkyl 1-Chlorocyclopropanecarboxylates
 Y. Nishii, E. Yoshida, T. Nagano, J. Motoyoshiya
 15th IUPAC Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS15), 2009Chemiluminescence of 9-benzylidene-N-methylacridans with electron-donating groups by chemically generated singlet oxygen. Application to metal ion sensing using azacrowned compound
 J. Motoyoshiya, T. Tanaka, M. Korue, Y. Nishii
 15th International symposium on Bioluminescence and chemiluminescence, 2009Chemiluminescence contolled by interaction of ligands and metal ions
 J. Motoyoshiya, T. Maruyama, R. Arai, Y. Nishii
 18th International Symposium on the Photochemistry and Photophysics of Coordination Compounds, 2009SmI2-Promoted Reformatsky-Type Reaction of Alkyl 1-Chlorocyclopropanecarboxylates
 E. Yoshida, T. Nagano, Y. Nishii, J. Motoyoshiya
 5th International Conference on Adovanced Fiber/Textile Materials 2009 in Ueda., 2009Synthetic study for novel biologically active compounds aiming to functionalized fibers (1) :Radical carbonylation and ring-expansion of gem-dichlorocyclopropanes for the synthesis of pyrethroids and b-amyloid plaque imaging reagent
 T. Nagano, H. Kimoto, Y. Yamanaka, J. Motoyoshiya,Y. Nishii
 4th International Conference on Advanced Fiber/Textile Materials 2007 in Ueda (ICAFTM2007), 2007Synthetic study for novel biologically active compounds aiming to functionalized fibers (2) : Highly regiocontrolled ipso-type and chirality exchange benzannulation of chiral diaryl gem-dichlorocycropropylmethanols and its application to total synthesis of axially chiral natural lignan lactones (antiviral, anti-HIV and antidepressant activity)
 E. Yoshida, D. Yamashita, J. Motoyoshiya, Y. Nishii
 4th International Conference on Advanced Fiber/Textile Materials 2007 in Ueda (ICAFTM2007), 2007