NOMURA Wataru
Faculty of Agriculture Department of Agricultural and Life Sciences Division of Bioscience and Biotechnology
Assistant Professor
Researcher Information
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Career
Educational Background
Research activity information
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Paper
- Activation of the cell wall integrity pathway negatively regulates TORC2-Ypk1/2 signaling through blocking eisosome disassembly in Saccharomyces cerevisiae.
Wataru Nomura; Yoshiharu Inoue
Communications biology, 7(1), 722-722, Jun. 2024, Refereed
Lead, Corresponding
- Metabolome analysis reveals that cyclic adenosine diphosphate ribose contributes to the regulation of differentiation in mice adipocyte.
Haruya Takahashi; Kento Nishitani; Satoko Kawarasaki; Agustin Martin-Morales; Hiroyuki Nagai; Hidetoshi Kuwata; Motohiro Tokura; Haruka Okaze; Shinsuke Mohri; Takeshi Ara; Tetsuro Ito; Wataru Nomura; Huei-Fen Jheng; Teruo Kawada; Kazuo Inoue; Tsuyoshi Goto
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 38(1), e23391, Jan. 2024, Refereed
Lead - Activation of the DNA damage checkpoint perturbs asymmetric localization of Kar9 to spindle pole bodies in Saccharomyces cerevisiae.
#Momoko Hayashida; #Wataru Nomura; Atsushi Shiojiri; Yoshiharu Inoue
Biochemical and biophysical research communications, 685, 149157-149157, Oct. 2023, Refereed
Lead, Corresponding - Combined treatment with teneligliptin and canagliflozin additively suppresses high-fat diet-induced body weight gain in mice with modulation of lipid metabolism-related gene expression.
Satoko Kawarasaki; Honami Sawazaki; Hiroaki Iijima; Haruya Takahashi; Wataru Nomura; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
European journal of pharmacology, 947, 175682-175682, May 2023, Refereed
Lead - 8-Prenyl daidzein and 8-prenyl genistein from germinated soybean modulate inflammatory response in activated macrophages.
Huei-Fen Jheng; Miho Takase; Satoko Kawarasaki; Zheng Ni; Shinsuke Mohri; Kanako Hayashi; Atsushi Izumi; Kuni Sasaki; Yu Shinyama; Jungin Kwon; Su-Ping Ng; Haruya Takahashi; Wataru Nomura; Rina Yu; Koji Ochiai; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
Bioscience, biotechnology, and biochemistry, 87(7), 747-757, Apr. 2023, Refereed
Lead - Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes.
Jungin Kwon; Yu-Sheng Yeh; Satoko Kawarasaki; Hiroto Minamino; Yoshihito Fujita; Yuko Okamatsu-Ogura; Haruya Takahashi; Wataru Nomura; Shigenobu Matsumura; Rina Yu; Kazuhiro Kimura; Masayuki Saito; Nobuya Inagaki; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
iScience, 26(3), 106161-106161, Mar. 2023, Refereed
Lead - Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1-p38-mTORC1 signaling axis in adipocytes.
#Su-Ping Ng; #Wataru Nomura; Haruya Takahashi; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto; Yoshiharu Inoue
The Biochemical journal, 479(21), 2279-2296, Nov. 2022, Refereed
Lead, Corresponding - Metabolomics reveals inosine 5'-monophosphate is increased during mice adipocyte browning.
Haruya Takahashi; Motohiro Tokura; Satoko Kawarasaki; Hiroyuki Nagai; Mari Iwase; Kento Nishitani; Haruka Okaze; Shinsuke Mohri; Tetsuro Ito; Takeshi Ara; Huei-Fen Jheng; Wataru Nomura; Teruo Kawada; Kazuo Inoue; Tsuyoshi Goto
The Journal of biological chemistry, 298(10), 102456-102456, Sep. 2022, Refereed
Lead - Roles of phosphatidylserine and phospholipase C in the activation of TOR complex 2 signaling in Saccharomyces cerevisiae.
Wataru Nomura; Su-Ping Ng; Terunao Takahara; Tatsuya Maeda; Teruo Kawada; Tsuyoshi Goto; Yoshiharu Inoue
Journal of cell science, 135(17), Sep. 2022, Refereed
Lead, Corresponding - Screening of flavor compounds using Ucp1-luciferase reporter beige adipocytes identified 5-methylquinoxaline as a novel UCP1-inducing compound.
Satoko Kawarasaki; Kazuki Matsuo; Hidetoshi Kuwata; Lanxi Zhou; Jungin Kwon; Zheng Ni; Haruya Takahashi; Wataru Nomura; Hisanori Kenmotsu; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
Bioscience, biotechnology, and biochemistry, 86(3), 380-389, Feb. 2022, Refereed
Lead - Methylglyoxal attenuates isoproterenol-induced increase in uncoupling protein 1 expression through activation of JNK signaling pathway in beige adipocytes.
Su-Ping Ng; Wataru Nomura; Haruya Takahashi; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
Biochemistry and biophysics reports, 28, 101127-101127, Dec. 2021, Refereed
Corresponding - Role of RhoGAP Rgd1 in Pkc1 signaling-related actin repolarization under heat shock stress in Saccharomyces cerevisiae.
Wataru Nomura; Ryota Futamata; Yoshiharu Inoue
Biochimica et biophysica acta. General subjects, 129853-129853, Jan. 2021, Refereed
Lead, Corresponding - Metabolome analysis revealed that soybean-Aspergillus oryzae interaction induced dynamic metabolic and daidzein prenylation changes.
Haruya Takahashi; Koji Ochiai; Kuni Sasaki; Atsushi Izumi; Yu Shinyama; Shinsuke Mohri; Wataru Nomura; Huei-Fen Jheng; Teruo Kawada; Kazuo Inoue; Tsuyoshi Goto
PloS one, 16(7), e0254190, 2021, Refereed
Lead - Methylglyoxal inhibits nuclear division through alterations in vacuolar morphology and accumulation of Atg18 on the vacuolar membrane in Saccharomyces cerevisiae.
Wataru Nomura; Miho Aoki; Yoshiharu Inoue
Scientific reports, 10(1), 13887-13887, Aug. 2020, Refereed, Not invited
Lead, Corresponding - Glycerol kinase stimulates uncoupling protein 1 expression by regulating fatty acid metabolism in beige adipocytes.
Mari Iwase; Soshi Tokiwa; Shigeto Seno; Takako Mukai; Yu-Sheng Yeh; Haruya Takahashi; Wataru Nomura; Huei-Fen Jheng; Sigenobu Matsumura; Tatsuya Kusudo; Naoki Osato; Hideo Matsuda; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
The Journal of biological chemistry, 295(20), 7033-7045, May 2020, Refereed, Not invited
Lead - Anti-Inflammatory and Antioxidative Properties of Isoflavones Provide Renal Protective Effects Distinct from Those of Dietary Soy Proteins against Diabetic Nephropathy.
Huei-Fen Jheng; Kanako Hayashi; Yasuki Matsumura; Teruo Kawada; Shigeto Seno; Hideo Matsuda; Kazuo Inoue; Wataru Nomura; Haruya Takahashi; Tsuyoshi Goto
Molecular nutrition & food research, 64(10), e2000015, May 2020, Refereed, Not invited
Lead - Long non-coding RNA 2310069B03Rik functions as a suppressor of Ucp1 expression under prolonged cold exposure in murine beige adipocytes.
Mari Iwase; Shoko Sakai; Shigeto Seno; Yu-Sheng Yeh; Tony Kuo; Haruya Takahashi; Wataru Nomura; Huei-Fen Jheng; Paul Horton; Naoki Osato; Hideo Matsuda; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
Bioscience, biotechnology, and biochemistry, 84(2), 305-313, Feb. 2020, Refereed, Not invited
Lead - Comparative Analysis of the Preventive Effects of Canagliflozin, a Sodium-Glucose Co-Transporter-2 Inhibitor, on Body Weight Gain Between Oral Gavage and Dietary Administration by Focusing on Fatty Acid Metabolism.
Satoko Kawarasaki; Honami Sawazaki; Hiroaki Iijima; Su-Ping Ng; Jungin Kwon; Shinsuke Mohri; Mari Iwase; Huei-Fen Jheng; Haruya Takahashi; Wataru Nomura; Kazuo Inoue; Teruo Kawada; Tsuyoshi Goto
Diabetes, metabolic syndrome and obesity : targets and therapy, 13, 4353-4359, 2020, Refereed
Lead - Contribution of phosphatidylserine to Rho1- and Pkc1-related repolarization of the actin cytoskeleton under stressed conditions in Saccharomyces cerevisiae.
Nomura W; Inoue Y
Small GTPases, 10(6), 449-455, Nov. 2019, Refereed, Not invited
Lead - Soy hydrolysate enhances the isoproterenol-stimulated lipolytic pathway through an increase in β-adrenergic receptor expression in adipocytes.
Ng SP; Nomura W; Mohri S; Takahashi H; Jheng HF; Ara T; Nagai H; Ito T; Kawada T; Goto T
Bioscience, biotechnology, and biochemistry, 83(9), 1782-1789, Sep. 2019, Refereed, Not invited
Corresponding - A new mouse model for noninvasive fluorescence-based monitoring of mitochondrial UCP1 expression.
Kawarasaki S; Kuwata H; Sawazaki H; Sakamoto T; Nitta T; Kim CS; Jheng HF; Takahashi H; Nomura W; Ara T; Takahashi N; Tomita K; Yu R; Kawada T; Goto T
FEBS letters, 593(11), 1201-1212, Jun. 2019, Refereed, Not invited
Lead - Lactobacillus helveticus-MIKI-020 enhances hepatic FGF21 expression and decreases the core body temperature during sleep in mice
Kiriyama K; Goto T; Yamamoto H; Ara T; Takahashi H; Jheng HF; Nomura W; Inoue H; Nakata R; Kawada T
Journal of Functional Foods, 54, 529-535, Mar. 2019, Refereed, Not invited
Lead - Endoplasmic Reticulum Stress Impaired Uncoupling Protein 1 Expression via the Suppression of Peroxisome Proliferator-Activated Receptor γ Binding Activity in Mice Beige Adipocytes.
Yuliana A; Daijo A; Jheng HF; Kwon J; Nomura W; Takahashi H; Ara T; Kawada T; Goto T
International journal of molecular sciences, 20(2), Jan. 2019, Refereed, Not invited
Lead - 10-Hydroxyoctadecanoic Acid from Lactobacillus amylovorus CP1563 Activates PPARalpha and Improves Dyslipidemia
Yumeko Aoki; Tomonori Sugawara; Sae Yanagihara; Haruya Takahashi; Wataru Nomura; Jheng Huei-Fen; Takeshi Ara; Tsuyoshi Goto; Teruo Kawada; Daisuke Sawada
Pharmacometrics, 95(3/4), 73-82, Nov. 2018, Refereed, Not invited
Lead - The dipeptidyl peptidase-4 (DPP-4) inhibitor teneligliptin enhances brown adipose tissue function, thereby preventing obesity in mice.
Takeda K; Sawazaki H; Takahashi H; Yeh YS; Jheng HF; Nomura W; Ara T; Takahashi N; Seno S; Osato N; Matsuda H; Kawada T; Goto T
FEBS open bio, 8(11), 1782-1793, Nov. 2018, Refereed, Not invited
Lead - The Mevalonate Pathway Is Indispensable for Adipocyte Survival.
Yeh YS; Jheng HF; Iwase M; Kim M; Mohri S; Kwon J; Kawarasaki S; Li Y; Takahashi H; Ara T; Nomura W; Kawada T; Goto T
iScience, 9, 175-191, Nov. 2018, Refereed, Not invited
Lead - β-adrenergic Receptor Stimulation Revealed a Novel Regulatory Pathway via Suppressing Histone Deacetylase 3 to Induce Uncoupling Protein 1 Expression in Mice Beige Adipocyte.
Yuliana A; Jheng HF; Kawarasaki S; Nomura W; Takahashi H; Ara T; Kawada T; Goto T
International journal of molecular sciences, 19(8), Aug. 2018, Refereed, Not invited
Lead - Toxicity of dihydroxyacetone is exerted through formation of methylglyoxal in Saccharomyces cerevisiae : effects on actin polarity and nuclear division.
Nomura W; Aoki M; Inoue Y
The Biochemical journal, 475(16), 2637-2652, Jul. 2018, Refereed, Not invited
Lead - Synthesized enone fatty acids resembling metabolites from gut microbiota suppress macrophage-mediated inflammation in adipocytes
Ha-Eun Yang; Yongjia Li; Akira Nishimura; Huei-Fen Jheng; Ana Yuliana; Ryuji Kitano-Ohue; Wataru Nomura; Nobuyuki Takahashi; Chu-Sook Kim; Rina Yu; Nahoko Kitamura; Si-Bum Park; Shigenobu Kishino; Jun Ogawa; Teruo Kawada; Tsuyoshi Goto
MOLECULAR NUTRITION & FOOD RESEARCH, 61(10), Oct. 2017, Refereed, Not invited
Lead
- Phosphatidylinositol 3,5-bisphosphate is involved in methylglyoxal-induced activation of the Mpk1 mitogen-activated protein kinase cascade in Saccharomyces cerevisiae
Wataru Nomura; Kazuhiro Maeta; Yoshiharu Inoue
JOURNAL OF BIOLOGICAL CHEMISTRY, 292(36), 15039-15048, Sep. 2017, Refereed, Not invited
Lead - Suksdorfin Promotes Adipocyte Differentiation and Improves Abnormalities in Glucose Metabolism via PPAR gamma Activation
Mari Iwase; Takayuki Yamamoto; Kanako Nishimura; Haruya Takahashi; Shinsuke Mohri; Yongjia Li; Huei-Fen Jheng; Wataru Nomura; Nobuyuki Takahashi; Chu-Sook Kim; Rina Yu; Masahiko Taniguchi; Kimiye Baba; Shigeru Murakami; Teruo Kawada; Tsuyoshi Goto
LIPIDS, 52(7), 657-664, Jul. 2017, Refereed, Not invited
Lead - The hepatokine FGF21 is crucial for peroxisome proliferator-activated receptor-alpha agonist-induced amelioration of metabolic disorders in obese mice
Tsuyoshi Goto; Mariko Hirata; Yumeko Aoki; Mari Iwase; Haruya Takahashi; Minji Kim; Yongjia Li; Huei-Fen Jheng; Wataru Nomura; Nobuyuki Takahashi; Chu-Sook Kim; Rina Yu; Shigeto Seno; Hideo Matsuda; Megumi Aizawa-Abe; Ken Ebihara; Nobuyuki Itoh; Teruo Kawada
JOURNAL OF BIOLOGICAL CHEMISTRY, 292(22), 9175-9190, Jun. 2017, Refereed, Not invited
Lead - Role of phosphatidylserine in the activation of Rho1-related Pkc1 signaling in Saccharomyces cerevisiae
Wataru Nomura; Yusuke Ito; Yoshiharu Inoue
CELLULAR SIGNALLING, 31, 146-153, Feb. 2017, Refereed, Not invited
Lead - 4-Hydroxyderricin, as a PPAR gamma Agonist, Promotes Adipogenesis, Adiponectin Secretion, and Glucose Uptake in 3T3-L1 Cells
Yongjia Li; Tsuyoshi Goto; Kanae Yamakuni; Haruya Takahashi; Nobuyuki Takahashi; Huei-Fen Jheng; Wataru Nomura; Masahiko Taniguchi; Kimiye Baba; Shigeru Murakami; Teruo Kawada
LIPIDS, 51(7), 787-795, Jul. 2016, Refereed, Not invited
Lead - 代謝ストレスによるTORシグナルの活性化
野村 亘; 井上善晴
化学と生物, 54(4), 273-280, Apr. 2016, Refereed, Not invited
Lead - Methylglyoxal Activates the Target of Rapamycin Complex 2-Protein Kinase C Signaling Pathway in Saccharomyces cerevisiae
Wataru Nomura; Yoshiharu Inoue
MOLECULAR AND CELLULAR BIOLOGY, 35(7), 1269-1280, Apr. 2015, Refereed, Not invited
Lead - 10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPAR gamma and stimulates adipogenesis
Tsuyoshi Goto; Young-Il Kim; Tomoya Furuzono; Nobuyuki Takahashi; Kanae Yamakuni; Ha-Eun Yang; Yongjia Li; Ryuji Ohue; Wataru Nomura; Tatsuya Sugawara; Rina Yu; Nahoko Kitamura; Si-Bum Park; Shigenobu Kishino; Jun Ogawa; Teruo Kawada
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 459(4), 597-603, Apr. 2015, Refereed, Not invited
Lead - 13-Oxo-9(Z),11(E),15(Z)-octadecatrienoic Acid Activates Peroxisome Proliferator-Activated Receptor gamma in Adipocytes
Haruya Takahashi; Hideyuki Hara; Tsuyoshi Goto; Kosuke Kamakari; Nomura Wataru; Shinsuke Mohri; Nobuyuki Takahashi; Hideyuki Suzuki; Daisuke Shibata; Teruo Kawada
LIPIDS, 50(1), 3-12, Jan. 2015, Refereed, Not invited
Lead - Reduction of Glucose Uptake through Inhibition of Hexose Transporters and Enhancement of Their Endocytosis by Methylglyoxal in Saccharomyces cerevisiae
Aya Yoshida; Dandan Wei; Wataru Nomura; Shingo Izawa; Yoshiharu Inoue
JOURNAL OF BIOLOGICAL CHEMISTRY, 287(1), 701-711, Jan. 2012, Refereed, Not invited
Lead - Glyoxalase system in yeasts: Structure, function, and physiology
Yoshiharu Inoue; Kazuhiro Maeta; Wataru Nomura
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 22(3), 278-284, May 2011, Refereed, Not invited
Lead - Methylglyoxal activates Gcn2 to phosphorylate eIF2 alpha independently of the TOR pathway in Saccharomyces cerevisiae
Wataru Nomura; Kazuhiro Maeta; Keiko Kita; Shingo Izawa; Yoshiharu Inoue
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 86(6), 1887-1894, May 2010, Refereed, Not invited
Lead - Calcineurin/Crz1 destabilizes Msn2 and Msn4 in the nucleus in response to Ca2+ in Saccharomyces cerevisiae
Yoshifumi Takatsume; Takumi Ohdate; Kazuhiro Maeta; Wataru Nomura; Shingo Izawa; Yoshiharu Inoue
BIOCHEMICAL JOURNAL, 427(2), 275-287, Apr. 2010, Refereed, Not invited
Lead - Role of Gcn4 for adaptation to methylglyoxal in Saccharomyces cerevisiae: Methylglyoxal attenuates protein synthesis through phosphorylation of eIF2 alpha
Wataru Nomura; Kazuhiro Maeta; Keiko Kita; Shingo Izawa; Yoshiharu Inoue
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 376(4), 738-742, Nov. 2008, Refereed, Not invited
Lead - Release of thioredoxin from Saccharomyces cerevisiae with environmental stimuli: solubilization of thioredoxin with ethanol
Yoko Takeuchi; Wataru Nomura; Takumi Ohdate; Shogo Tamasu; Hiroshi Masutani; Kazuo Murata; Shingo Izawa; Junji Yodoi; Yoshiharu Inoue
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 75(6), 1393-1399, Jul. 2007, Refereed, Not invited
Lead - Efficient extraction of thioreodoxin from Saccharomyces cerevisiae by ethanol
Yoshiharu Inoue; Wataru Nomura; Yoko Takeuchi; Takumi Ohdate; Shogo Tamasu; Atsushi Kitaoka; Yoshifumi Kiyokawa; Hiroshi Masutani; Kazuo Murata; Yoshinori Wakai; Shingo Izawa; Junji Yodoi
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 73(5), 1672-1675, Mar. 2007, Refereed, Not invited
Lead - Green tea polyphenols function as prooxidants to activate oxidative-stress-responsive transcription factors in yeasts
Kazuhiro Maeta; Wataru Nomura; Yoshifumi Takatsume; Shingo Izawa; Yoshiharu Inoue
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 73(2), 572-580, Jan. 2007, Refereed, Not invited
Lead
Books and other publications
- 脂肪酸および脂肪酸代謝物が褐色脂肪組織機能に及ぼす影響～ω-3脂肪酸を中心に～
後藤剛; 岩瀬麻里; 川原崎聡子; 高橋春弥; 野村亘; 井上和生; 河田照雄, Joint work
BIO INDUSTRY (シーエムシー出版), Oct. 2020脂肪組織機能を制御する食品由来成分に関する研究
岩瀬麻里; 川原崎聡子; 毛利晋輔; 高橋春弥; 野村亘; Huei-Fen Jheng; 井上和生; 河田照雄; 後藤剛, Joint work
日本機能性食品医用学会, 2020The Yeast Role in Medical Applications
Yoshiharu Inoue; Wataru Nomura, Contributor, TOR signaling in budding yeast
InTechOpen, Jan. 2018Lectures, oral presentations, etc.
- 酵母の細胞壁ストレスを感知するCWI経路は細胞膜健全性に寄与するTORC2シグナルを負に制御する
野村 亘; 井上善晴
第46回日本分子生物学会年会 シンポジウム, Dec. 2023膜ストレスを感知するTORシグナルの制御機構
野村 亘
生理化学研究ユニット第10回シンポジウム, Dec. 2020出芽酵母のストレス応答におけるPKCシグナルの制御機構
野村 亘
酵母研究会 第85回講演会, Jul. 2018酵母のストレス応答におけるPKCシグナル制御機構に関する研究
野村 亘
第65回 日本生化学会近畿支部例会 近畿支部奨励賞受賞記念講演, May 2018解糖系代謝物によるTORC2シグナルの活性化
野村 亘; 河田照雄; 井上善晴
第36回 日本分子生物学会年会 ワークショップ, Dec. 2013Affiliated academic society
Research Themes
- 酵母におけるプロテインキナーゼCによるTORC2シグナルの負の制御
科学研究費助成事業 基盤研究(C), 日本学術振興会, 基盤研究(C)
京都大学
01 Apr. 2022 - 31 Mar. 2025 - TORC2シグナルの活性化に寄与する細胞膜脂質の作用機序の解析
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Kyoto University
01 Apr. 2019 - 31 Mar. 2022 - Analysis of the regulation of TORC2 signaling by phosphatidylserine
Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B)
Kyoto University
01 Apr. 2017 - 31 Mar. 2019 - Involvement of glycolytic metabolite in pathogenic mechanism of diabetes: verification of new model of insulin-resistance development
Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research
Kyoto University
01 Apr. 2014 - 31 Mar. 2016 - メタボリックシグナリング：解糖系代謝物によるＴＯＲＣ２の新規活性化機構の解明
Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows, Japan Society for the Promotion of Science, Grant-in-Aid for JSPS Fellows
Kyoto University
01 Apr. 2012 - 31 Mar. 2015
