Anatomy, stem cell biology

Stem Cell

2008 - Present
Shinshu University, 医学部組織発生学講座, 助教

2006 - 2006
University of California, Berkeley, Post.Doc

2006 - 2006
Shinshu University, 医学部組織発生学講座, 助手

2002 - 2006
Shinshu University, 医学部組織発生学講座, 大学院生（博士課程）

2002 - 2006, Shinshu University, School of Medicine, 組織発生学講座

2000 - 2003, 河北医科大学, 臨床医学

Present, University of California, Berkeley, Chemical Engineering

2012
ISSCR, Young Traval Award
岳 鳳鳴

Unraveling the cellular mechanisms of thiopurine-induced pancreatitis in pediatric inflammatory bowel disease: Insights from induced pluripotent stem cell models.
Paola Rispoli; Elena Genova; Fengming Yue; Kohei Johkura; Martina Franzin; Ute Hofmann; Matthias Schwab; Rosalba Monica Ferraro; Elena Laura Mazzoldi; Silvia Clara Giliani; Giovanna Piovani; Matteo Bramuzzo; Stefano Martelossi; Erasmo Miele; Massimo Martinelli; Federico Marchetti; Marco Pelin; Giuliana Decorti; Marianna Lucafò; Gabriele Stocco
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 191, 118539-118539, Oct. 2025

Time-efficient strategies in human iPS cell-derived pancreatic progenitor differentiation and cryopreservation: advancing towards practical applications.
Elena Genova; Paola Rispoli; Yue Fengming; Johkura Kohei; Matteo Bramuzzo; Roberta Bulla; Marianna Lucafò; Rosalba Monica Ferraro; Giuliana Decorti; Gabriele Stocco
Stem cell research & therapy, 15(1), 483-483, Dec. 2024

Three-Dimensional Modeling with Osteoblast-like Cells under External Magnetic Field Conditions Using Magnetic Nano-Ferrite Particles for the Development of Cell-Derived Artificial Bone.
Chuang Ma; Makoto Izumiya; Hidehiko Nobuoka; Rintaro Ueno; Masaki Mimura; Katsuya Ueda; Haruka Ishida; Daihachiro Tomotsune; Kohei Johkura; Fengming Yue; Naoto Saito; Hisao Haniu
Nanomaterials (Basel, Switzerland), 14(3), Jan. 2024

Evaluating the Cytocompatibility of Lactic Acid-Extracted Barramundi Skin Collagen for Cell Culture Applications"
信州医学雑誌, 2024

Unraveling the Influence of Folic Acid on Osteogenic differentiation: Insights from Induced Pluripotent Stem Cells
信州医学雑誌, 2024

Pathophysiological Investigation of Skeletal Deformities of Musculocontractural Ehlers-Danlos Syndrome Using Induced Pluripotent Stem Cells.
Fengming Yue; Takumi Era; Tomomi Yamaguchi; Tomoki Kosho
Genes, 14(3), Mar. 2023

Generation of an induced pluripotent stem cell lines HMSCASTi002-A from peripheral blood mononuclear cells of a 38-year-old healthy female individual.
Xian Xian; Jingrui Liu; Jiamin Zhang; Peipei Hao; Yingtong Zhai; Jingke Cheng; Fengming Yue; Min Ma; Zhanchi Zhang; Feng Luan; Qian Ren
Stem cell research, 64, 102907-102907, Oct. 2022

Generation of an induced pluripotent stem cell lines HMSCASTi001-A from peripheral blood mononuclear cells of a 35-year-old healthy male.
Zhanchi Zhang; Jingrui Liu; Jiamin Zhang; Xian Xian; Peipei Hao; Yingtong Zhai; Jingke Cheng; Fengming Yue; Feng Luan; Min Ma; Qian Ren
Stem cell research, 64, 102908-102908, Oct. 2022

Lipocalin-2 inhibits pancreatic cancer stemness via the AKT/c-Jun pathway.
Peipei Hao; Jiamin Zhang; Shu Fang; Miaomiao Jia; Xian Xian; Sinan Yan; Yunpeng Wang; Qian Ren; Fengming Yue; Huixian Cui
Human cell, 35(5), 1475-1486, Sep. 2022

Lipocalin2 promotes cell proliferation and migration in ovarian cancer through activation of the ERK/GSK3β/β-catenin signaling pathway.
Peipei Hao; Haili Li; Aiyuan Wu; Jiamin Zhang; Chang Wang; Xian Xian; Qian Ren; Nana Hao; Yunpeng Wang; Fengming Yue; Huixian Cui
Life sciences, 262, 118492-118492, Dec. 2020

Inhibiting effect of MicroRNA-3619-5p/PSMD10 axis on liver cancer cell growth in vivo and in vitro.
Peipei Hao; Fengming Yue; Xian Xian; Qian Ren; Huixian Cui; Yunpeng Wang
Life sciences, 254, 117632-117632, Aug. 2020

Essential role of PTPN11 mutation in enhanced haematopoietic differentiation potential of induced pluripotent stem cells of juvenile myelomonocytic leukaemia.
Shigemura T, Matsuda K, Kurata T, Sakashita K, Okuno Y, Muramatsu H, Yue F, Ebihara Y, Tsuji K, Sasaki K, Nakahata T, Nakazawa Y, Koike K.
Br J Haematol, 187(2), 163-173, 2019

Cell biological profiling of reprogrammed cancer stem cell-like colon cancer cells maintained in culture.
Hirashima K; Yue F; Kobayashi M; Uchida Y; Nakamura S; Tomotsune D; Matsumoto K; Takizawa-Shirasawa S; Yokoyama T; Kanno H; Sasaki K
Cell and tissue research, 375(3), 697-707, Oct. 2018, Refereed, Not invited

Simulation of Embryonic Environments Produced by the Effect of Estradiol on Induced Pluripotent Stem Cells
J Regen Med, Jul. 2018, Refereed, Not invited

Earlobe-like peritoneal appendage near the angle of His: a useful landmark for demarcating the lateral margin of the gastric cardia
Kanji Hirashima; Fengming Yue; Daihachiro Tomotsune; Katsunori Sasaki
Anatomical Science International, 93(1), 82-87, Jan. 2018, Refereed, Not invited

Induced Pluripotent Stem Cells as a Model for Therapy Personalization of Pediatric Patients: Disease Modeling and Drug Adverse Effects Prevention.
Genova E; Pelin M; Sasaki K; Yue F; Lanzi G; Masneri S; Ventura A; Stocco G; Decorti G
Current medicinal chemistry, 25(24), 2826-2839, 2018, Refereed, Not invited

Cardiac portion of the stomach: a deep region within the abdomen
Abdomen, Jul. 2017, Refereed, Not invited

Simple Isolation of Pancreatic Progenitor Cells from Human Induced Pluripotent Stem Cells Using the ALDEFLUOR
Nakamura S; Takizawa S; Yokoyama T; Tomotsune D; Yue F; Sasaki K
Stem Cell: Advanced Research and Therapy., Jan. 2017, Refereed, Not invited

Reprogramming of retinoblastoma cancer cells into cancer stem cells
Fengming Yue; Kanji Hirashima; Daihachiro Tomotsune; Sakiko Takizawa-Shirasawa; Tadayuki Yokoyama; Katsunori Sasaki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 482(4), 549-555, Jan. 2017, Refereed, Not invited

Enrichment of Pluripotent Stem Cell-Derived Hepatocyte-Like Cells by Ammonia Treatment
Daihachiro Tomotsune; Kanji Hirashima; Masako Fujii; Fengming Yue; Ken Matsumoto; Sakiko Takizawa-Shirasawa; Tadayuki Yokoyama; Katsunori Sasaki
PLOS ONE, 11(9), e0162693, Sep. 2016, Refereed, Not invited

Patients' Induced Pluripotent Stem Cells to Model Drug Induced Adverse Events: A Role in Predicting Thiopurine Induced Pancreatitis?
Gabriele Stocco; Gaetana Lanzi; Fengming Yue; Silvia Giliani; Katsunori Sasaki; Alberto Tommasini; Marco Pelin; Stefano Martelossi; Alessandro Ventura; Giuliana Decorti
CURRENT DRUG METABOLISM, 17(1), 91-98, 2016, Refereed, Not invited

New model for cardiomyocyte sheet transplantation using a virus-cell fusion technique
Yuto Takahashi; Daihachiro Tomotsune; Sakiko Takizawa; Fengming Yue; Mika Nagai; Tadayuki Yokoyama; Kanji Hirashima; Katsunori Sasaki
WORLD JOURNAL OF STEM CELLS, 7(5), 883-893, Jun. 2015, Refereed, Not invited

Experimental splenosis in the liver and lung spread through the vasculature.
Seguchi S, Yue F, Asanuma K, Sasaki K.
Cell Tissue Res, 360(2), 287-96, May 2015

FGF7 and cell density are required for final differentiation of pancreatic amylase-positive cells from human ES cells
Sakiko Takizawa-Shirasawa; Susumu Yoshie; Fengming Yue; Akimi Mogi; Tadayuki Yokoyama; Daihachiro Tomotsune; Katsunori Sasaki
Cell and Tissue Research, 354(3), 751-759, Dec. 2013, Refereed, Not invited

Unique kinetics of Oct3/4 microlocalization following dissociation of human embryonic stem cell colonies
Hinako Ichikawa; Yoshiya Kanoh; Sakiko Shirasawa; Tadayuki Yokoyama; Fengming Yue; Daihachiro Tomotsune; Katsunori Sasaki
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER, 195(1), 50-56, 2013, Refereed, Not invited

Gene pathway analysis of the mechanism by which the Rho-associated kinase inhibitor Y-27632 inhibits apoptosis in isolated thawed human embryonic stem cells
Hinako Ichikawa; Naohiro Nakata; Youichi Abo; Sakiko Shirasawa; Tadayuki Yokoyama; Susumu Yoshie; Fengming Yue; Daihachiro Tomotsune; Katsunori Sasaki
CRYOBIOLOGY, 64(1), 12-22, Feb. 2012, Refereed, Not invited

In Vitro Transdifferentiation of HepG2 Cells to Pancreatic-Like Cells by CCl4, D-Galactosamine, and ZnCl2
Yoshiya Kanoh; Daihachiro Tomotsune; Sakiko Shirasawa; Susumu Yoshie; Hinako Ichikawa; Tadayuki Yokoyama; Shin-Ichi Mae; Jun Ito; Masahiro Mizuguchi; Ken Matsumoto; Fengming Yue; Katsunori Sasaki
PANCREAS, 40(8), 1245-1252, Nov. 2011, Refereed, Not invited

Freeze-thawing single human embryonic stem cells induce e-cadherin and actin filament network disruption via g13 signaling.
Ichikawa H; Yoshie S; Shirasawa S; Yokoyama T; Yue F; Tomotsune D; Sasaki K
Cryo letters, 32(6), 516-524, Nov. 2011, Refereed, Not invited

Pancreatic exocrine enzyme-producing cell differentiation via embryoid bodies from human embryonic stem cells
Sakiko Shirasawa; Susumu Yoshie; Fengming Yue; Hinako Ichikawa; Tadayuki Yokoyama; Mika Nagai; Daihachiro Tomotsune; Masao Hirayama; Katsunori Sasaki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 410(3), 608-613, Jul. 2011, Refereed, Not invited

A Novel Stepwise Differentiation of Functional Pancreatic Exocrine Cells from Embryonic Stem Cells
Sakiko Shirasawa; Susumu Yoshie; Tadayuki Yokoyama; Daihachiro Tomotsune; Fengming Yue; Katsunori Sasaki
STEM CELLS AND DEVELOPMENT, 20(6), 1071-1078, Jun. 2011, Refereed, Not invited

Differentiation of primate ES cells into retinal cells induced by ES cell-derived pigmented cells
Fengming Yue; Kohei Johkura; Sakiko Shirasawa; Tadayuki Yokoyama; Yuji Inoue; Daihachiro Tomotsune; Katsunori Sasaki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 394(4), 877-883, Apr. 2010, Refereed, Not invited

Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells
Shin-Ichi Mae; Sakiko Shirasawa; Susumu Yoshie; Fumi Sato; Yoshiya Kanoh; Hinako Ichikawa; Tadayuki Yokoyama; Fengming Yue; Daihachiro Tomotsune; Katsunori Sasaki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 393(4), 877-882, Mar. 2010, Refereed, Not invited

Bone marrow stromal cells as an inducer for cardiomyocyte differentiation from mouse embryonic stem cells
Fengming Yue; Kohei Johkura; Daihachiro Tomotsune; Sakiko Shirasawa; Tadayuki Yokoyama; Mika Nagai; Katsunori Sasaki
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER, 192(5), 314-321, 2010, Refereed, Not invited

Hepatocyte differentiation from human ES cells using the simple embryoid body formation method and the staged-additional cocktail.
Katsunori Sasaki; Hinako Ichikawa; Shunsuke Takei; Hee Sung No; Daihachiro Tomotsune; Yoshiya Kano; Tadayuki Yokoyama; Sakiko Sirasawa; Akimi Mogi; Susumu Yoshie; Shujiro Sasaki; Satoshi Yamada; Ken Matsumoto; Masahiro Mizuguchi; Fengming Yue; Yoshiki Tanaka
TheScientificWorldJournal, 9, 884-90, Sep. 2009, Refereed, Not invited

Cryopreservation of mouse embryoid bodies
Hinako Ichikawa; Heesung No; Shunsuke Takei; Itsukei Takashimizu; Yue Fengming; Li Cui; Naoko Ogiwara; Kohei Johkura; Yoshiteru Nishimoto; Katsunori Sasaki
CRYOBIOLOGY, 54(3), 290-293, Jun. 2007, Refereed, Not invited

Glucagon-like peptide-1 differentiation of primate embryonic stem cells into insulin-producing cells
Fengming Yue; Li Cui; Kohei Johkura; Naoko Ogiwara; Katsunori Sasaki
TISSUE ENGINEERING, 12(8), 2105-2116, Aug. 2006, Refereed, Not invited

Induction of midbrain dopaminergic neurons from primate embryonic stem cells by coculture with Sertoli cells
Fengming Yue; Li Cui; Kohei Johkura; Naoko Ogiwara; Katsunori Sasaki
STEM CELLS, 24(7), 1695-1706, Jul. 2006, Refereed, Not invited

Natriuretic peptides in ectopic myocardial tissues originating from mouse embryonic stem cells
K Johkura; L Cui; FM Yue; K Nitta; S Takei; Y Okouchi; K Asanuma; N Ogiwara; K Sasaki
MICROSCOPY RESEARCH AND TECHNIQUE, 66(4), 165-172, Mar. 2005, Refereed, Not invited

Phenotype-specific cells with proliferative potential are produced by polyethylene glycol-induced fusion of mouse embryonic stem cells with fetal cardiomyocytes
S Takei; M Yamamoto; L Cui; F Yue; K Johkura; N Ogiwara; H Iinuma; K Okinaga; K Sasaki
CELL TRANSPLANTATION, 14(9), 701-708, 2005, Refereed, Not invited

Spatial distribution and initial changes of SSEA-1 and other cell adhesion-related molecules on mouse embryonic stem cells before and during differentiation
L Cui; K Johkura; FM Yue; N Ogiwara; Y Okouchi; K Asanuma; K Sasaki
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 52(11), 1447-1457, Nov. 2004, Refereed, Not invited

最新動物細胞培養の手法と細胞死、増殖不良、細 胞変異を防止する技術
岳 鳳鳴; 佐々木 克典, Joint work, 第2章第８節
技術情報協会, 2014

Regenerative Medicine and Tissue Engineering
岳 鳳鳴, Joint work, Induce Differentiation of ESCs by co-culture system
In Tech., 2013

Regenerative Medicine
A Strategy Using Pluripotent Stem Cell-Derived Hepatocytes for Stem Cell-Based Therapies
2011

Induced pluripotent stem cells as an in vitro model for the study of drugs
岳 鳳鳴
Clinical trials and off-label in pediatry: toward precision medicine, Oct. 2018, Invited

Disease Model with iPS Cells from D4ST1-Deficient Ehlers-Danlos Syndrome (DD-EDS)
岳 鳳鳴
International Symposium of Regenerative Medicine, Jan. 2017, Invited

The application of stem cells in Pancreatic Disease
岳 鳳鳴
International symposium on stem cells, Nov. 2016, Invited

Stem cell research and application
岳 鳳鳴
解剖学会国際形態学学会, Aug. 2014, Invited

人体構造機能学各論Ⅰ・Ⅱ
松本短期大学

解剖学演習・実習Ⅰ・Ⅱ
信州大学医学部

人体の構造
信州大学医学部

ISSCR

再生医療学会

Elucidation of Spinal Deformation Mechanisms in Musculocontractural Ehlers-Danlos Syndrome Utilizing Induced Pluripotent Stem Cells
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
01 Apr. 2024 - 31 Mar. 2028

筋拘縮型エーラス・ダンロス症候群の創傷治癒過程におけるデルマタン硫酸の役割
科学研究費助成事業, 日本学術振興会, 基盤研究(C)
信州大学
01 Apr. 2023 - 31 Mar. 2027

リプログラミングによる膵癌幹細胞治療に応用可能な漢方薬の探索
公益財団法人小林国際奨学財団研究助成金, 公益財団法人小林国際奨学財団
Apr. 2017 - Mar. 2019

リプログラミングよる膵癌由来癌幹細胞の創出と網羅的解析
平成２８年度Ａ評価者研究費支援, 信州大学
Apr. 2016 - Mar. 2017

リプログラミングによるグリア芽腫由来癌幹細胞の創出と漢方薬選択
公益財団法人日中医学協会 助成金, 日中医学協会
Apr. 2016 - Mar. 2017

リプログラミングよる膵癌由来癌幹細胞の創出と網羅的解析
アイバワーク若手医学研究者支援事業
Apr. 2013 - Mar. 2014

Patient-specific iPS cell-derived vessel smooth cells of DD-EDS syndrom
若手研究（B), 日本学術振興会
Apr. 2012 - Mar. 2015

Differentiation of Human iPS into Retinal Cells Induced by ES Cell-Derived Pigmented Cells
信大若手研究者萌芽研究支援事業, 信州大学
Apr. 2010 - Mar. 2011

Human CHST14-corrected induced pluripotent stem cells as cell therapy for ski n hyperextensibility in Ehlers-Danlos syndrome
平成３０年度Ａ評価者研究費支援, 信州大学

induce specific differentiation of stem cells

がん幹細胞