Ph. D. (Medicine), Japan

Prolonged Myocardial Regenerative Capacity in Neonatal Opossum.
Nishiyama, C., Saito, Y., Sakaguchi, A., Kaneko, M., Kiyonari, H., Xu, Y., Arima, Y., Uosaki, H. and Kimura, W.*
Circulation, 146, 125-139, 2022
Corresponding

Hypoxia induces heart regeneration in adult mice.
Nakada, Y., Canseco, D. C., Thet S., Abdisalaam S., Asaithaymby A., Santos C. X., Shah A., Zhang, H., Faber, J. E., Kinter M. T., Szweda, L. I., Xing, C., Deberardinis, R., Oz O., Lu Z., Zhang C. C., Kimura, W.* and Sadek, H. A.*
Nature, 541, 222-227, 2017
Corresponding

Inflammation induced oxidative stress mediates gene fusion formation in prostate cancer.
Mani, R. S., Amin, M. A., Li, X., Kalyana-Sundaram, S., Veeneman, B. A., Wang, L., Ghosh, A., Aslam, A., Ramanand, S. G., Rabquer, B. J., Kimura W., Tran, M., Cao, X., Roychowdhury, S., Dhanasekaran, S. M., Palanisamy, N., Sadek, H. A., Kapur, P., Koch, A. E., and Chinnaiyan, A. M.
Cell Rep., 17, 2620-2631, 2016

Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias.
Koizumi A., Sasano T., Kimura W., Miyamoto Y., Aiba T., Ishikawa T., Nogami A., Fukamizu S., Sakurada H., Takahashi Y., Nakamura H., Ishikura T., Koseki H., Arimura T., Kimura A., Hirao K., Isobe M., Shimizu W., Miura N., Furukawa T.
Eur Heart J., 37, 1469-1475, 2016

Human ventricular unloading induces cardiomyocyte proliferation.
Canseco, D. C., Kimura, W., Garg, S., Mukherjee, S., Bhattacharya, S., Abdisalaam, S., Das, S., Asaithamby. A., Mammen, P. P. and Sadek, H. A.
J. Am. Coll. Cardiol., 65, 892-900, 2015

Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart.
Kimura, W., Xiao, F., Canseco, D. C., Muralidhar, S., Thet S., Zhang, H. M., Abderrahman, Y., Chen, R., Garcia, J. A., Shelton, J. M., Richardson, J. A., Ashour, A. M., Asaithamby, A., Liang, H., Xing, C., Lu, Z., Zhang, C. C. and Sadek, H. A.
Nature, 523, 226-230, 2015
Lead

FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature.
Sabine, A., Bovay, E., Demir C. S., Kimura, W., Jaquet, M., Agalarov, Y., Zangger, N., Scallan, J. P., Graber, W., Gulpinar, E., Kwak, B. R., Mäkinen, T., Martinez-Corral, I., Ortega, S., Delorenzi, M., Kiefer, F., Davis, M. J., Djonov, V., Miura, N. and Petrova, T. V.
J. Clin. Invest., 125, 3861-3877, 2015

Surgical models for cardiac regeneration in neonatal mice.
Mahmoud, A. I., Porrello, E. R., Kimura, W., Olson, E. N. and Sadek, H. A.
Nat. Protoc., 9, 305-311, 2014

The oxygen rich postnatal environment induces cardiomyocyte cell cycle arrest through DNA damage response.
Puente, B. N., Kimura, W., Muralidhar, S. A., Moon, J., Amatruda, J. F., Phelps, K. L., Grinsfelder, D., Rothermel, B. A., Chen, R., Garcia, J. A., Santos, C. X., Thet, S., Mori, E., Kinter, M. T., Rindler, P. M., Zacchigna, S., Mukherjee, S., Chen, D. J., Mahmoud, A. I., Giacca, M., Rabinovitch, P. S., Aroumougame, A., Shah, A. M., Szweda, L. I. and Sadek, H. A.
Cell, 157, 565-579, 2014
Lead

Meis1 regulates postnatal cardiomyocyte cell cycle arrest.
Mahmoud, A. I., Kocabas, F., Muralidhar, S. A., Kimura, W., Koura, A. S., Thet, S., Porrello, E. R. and Sadek, H. A.
Nature, 497, 249-253, 2013