
KIMURA Wataru
Academic Assembly School of Medicine and Health Sciences Institute of Medicine
School of Medicine Department of Molecular Pharmacology
Professor
Researcher Information
Research activity information
Paper
- Paracrine IGFBP3 spatially coordinates IGF signaling to induce myocardial regeneration in mice.
Shah R Ali; Ngoc Uyen Nhi Nguyen; Waleed Elhelaly; Ching-Cheng Hsu; Shujuan Li; Ivan Menendez-Montes; Zhaoning Wang; Miao Cui; Abdallah Elnwasany; Feng Xiao; Jisheng Sun; Suwannee Thet; Nicholas T Lam; Alisson Cardoso; Ana Helena Pereira; Jinhu Wang; Eric N Olson; Michael T Kinter; Luke I Szweda; John Shelton; Wataru Kimura; Hesham A Sadek
Journal of Molecular and Cellular Cardiology, 207, 93-106, Aug. 2025, Refereed

- Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis
Feng Xiao; Ngoc Uyen Nhi Nguyen; Ping Wang; Shujuan Li; Ching-Cheng Hsu; Suwannee Thet; Wataru Kimura; Xiang Luo; Nicholas T. Lam; Ivan Menendez-Montes; Waleed M. Elhelaly; Alisson Campos Cardoso; Ana Helena Macedo Pereira; Rohit Singh; Sakthivel Sadayappan; Mohammed Kanchwala; Chao Xing; Feria A. Ladha; J. Travis Hinson; Roger J. Hajjar; Joseph A. Hill; Hesham A. Sadek
Circulation, 150(10), 791-805, Sep. 2024, Refereed

- 再生医療における低酸素の応用可能性
齋藤祐一; 西山千尋; 木村航
月刊細胞, 54, 364-367, Jun. 2022, Invited
Last, Corresponding - Gene Expression Profiles of Human Cerebral Organoids Identify PPAR Pathway and PKM2 as Key Markers for Oxygen-Glucose Deprivation and Reoxygenation
Naoki Iwasa; Takeshi K. Matsui; Naohiko Iguchi; Kaoru Kinugawa; Naritaka Morikawa; Yoshihiko M. Sakaguchi; Tomo Shiota; Shinko Kobashigawa; Mari Nakanishi; Masaya Matsubayashi; Riko Nagata; Sotaro Kikuchi; Tatsuhide Tanaka; Nobuyuki Eura; Takao Kiriyama; Tesseki Izumi; Kozue Saito; Hiroshi Kataoka; Yuichi Saito; Wataru Kimura; Akio Wanaka; Yuhei Nishimura; Eiichiro Mori; Kazuma Sugie
Frontiers in Cellular Neuroscience, 15, 605030-605030, Jun. 2021, Refereed

- 環境ストレス応答と相分離
木村航
現代科学増刊 相分離生物学の全貌, 2020
Corresponding - 心筋新生による心臓再生 ―進化発生学(Evo-Devo)から学ぶ基礎研究,そして臨床に向けた課題―
木村航
再生医療の事業化と共同開発戦略, 2019
Corresponding - 心筋細胞増殖制御機構の解明
坂口あかね; 木村航
心臓, 50, 1272-1275, 2018, Invited
Last, Corresponding - 酸素代謝による心筋細胞の細胞周期制御と心臓再生
木村航
生化学, 90, 385-387, 2018, Invited
Corresponding - Hypoxia induces heart regeneration in adult mice
Yuji Nakada; Diana C. Canseco; SuWannee Thet; Salim Abdisalaam; Aroumougame Asaithamby; Celio X. Santos; Ajay M. Shah; Hua Zhang; James E. Faber; Michael T. Kinter; Luke I. Szweda; Chao Xing; Zeping Hu; Ralph J. . Deberardinis; Gabriele Schiattarella; Joseph A. Hill; Orhan Oz; Zhigang Lu; Cheng Cheng Zhang; Wataru Kimura; Hesham A. Sadek
NATURE, 541(7636), 222-+, Jan. 2017, Refereed
Corresponding


- 酸素代謝による心筋細胞の増殖制御
木村航
生体の科学, 68, 548-553, 2017, Invited - 低酸素環境による成体マウスでの心臓再生
中田祐二; 木村航; Hesham A. Sadek
実験医学, 35, 981-985, 2017, Invited - Inflammation-Induced Oxidative Stress Mediates Gene Fusion Formation in Prostate Cancer
Ram S. Mani; Mohammad A. Amin; Xiangyi Li; Shanker Kalyana-Sundaram; Brendan A. Veeneman; Lei Wang; Aparna Ghosh; Adam Aslam; Susmita G. Ramanand; Bradley J. Rabquer; Wataru Kimura; Maxwell Tran; Xuhong Cao; Sameek Roychowdhury; Saravana M. Dhanasekaran; Nallasivam Palanisamy; Hesham A. Sadek; Payal Kapur; Alisa E. Koch; Arul M. Chinnaiyan
CELL REPORTS, 17(10), 2620-2631, Dec. 2016, Refereed


- Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias
Akiko Koizumi; Tetsuo Sasano; Wataru Kimura; Yoshihiro Miyamoto; Takeshi Aiba; Taisuke Ishikawa; Akihiko Nogami; Seiji Fukamizu; Harumizu Sakurada; Yoshihide Takahashi; Hiroaki Nakamura; Tomoyuki Ishikura; Haruhiko Koseki; Takuro Arimura; Akinori Kimura; Kenzo Hirao; Mitsuaki Isobe; Wataru Shimizu; Naoyuki Miura; Tetsushi Furukawa
EUROPEAN HEART JOURNAL, 37(18), 1469-1475, May 2016, Refereed


- FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature
Amelie Sabine; Esther Bovay; Cansaran Saygili Demir; Wataru Kimura; Muriel Jaquet; Yan Agalarov; Nadine Zangger; Joshua P. Scallan; Werner Graber; Elgin Gulpinar; Brenda R. Kwak; Taija Makinen; Ines Martinez-Corral; Sagrario Ortega; Mauro Delorenzi; Friedemann Kiefer; Michael J. Davis; Valentin Djonov; Naoyuld Miura; Tatiana V. Petrova
JOURNAL OF CLINICAL INVESTIGATION, 125(10), 3861-3877, Oct. 2015, Refereed


- Hypoxic metabolism in human hematopoietic stem cells
Fatih Kocabas; Li Xie; Jingjing Xie; Zhuo Yu; Ralph J. DeBerardinis; Wataru Kimura; SuWannee Thet; Ahmed F. Elshamy; Hesham Abouellail; Shalini Muralidhar; Xiaoye Liu; Chiqi Chen; Hesham A. Sadek; Cheng Cheng Zhang; Junke Zheng
CELL AND BIOSCIENCE, 5, 39, Jul. 2015, Refereed


- Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart
Wataru Kimura; Feng Xiao; Diana C. Canseco; Shalini Muralidhar; SuWannee Thet; Helen M. Zhang; Yezan Abderrahman; Rui Chen; Joseph A. Garcia; John M. Shelton; James A. Richardson; Abdelrahman M. Ashour; Aroumougame Asaithamby; Hanquan Liang; Chao Xing; Zhigang Lu; Cheng Cheng Zhang; Hesham A. Sadek
NATURE, 523(7559), 226-U243, Jul. 2015, Refereed
Lead


- Human Ventricular Unloading Induces Cardiomyocyte Proliferation
Diana C. Canseco; Wataru Kimura; Sonia Garg; Shibani Mukherjee; Souparno Bhattacharya; Salim Abdisalaam; Sandeep Das; Aroumougame Asaithamby; Pradeep P. A. Mammen; Hesham A. Sadek
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 65(9), 892-900, Mar. 2015, Refereed


- Foxc2 in pharyngeal arch mesenchyme is important for aortic arch artery remodelling and ventricular septum formation
Mohammad Khaja Mafij Uddin; Wataru Kimura; Tomoyuki Ishikura; Haruhiko Koseki; Nobuaki Yoshida; Mohammod Johirul Islam; Mohammed Badrul Amin; Kasumi Nakamura; Yi-Xin Wu; Eiji Sato; Kazushi Aoto; Naoyuki Miura
BIOMEDICAL RESEARCH-TOKYO, 36(4), 235-245, 2015, Refereed


- The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response
Bao N. Puente; Wataru Kimura; Shalini A. Muralidhar; Jesung Moon; James F. Amatruda; Kate L. Phelps; David Grinsfelder; Beverly A. Rothermel; Rui Chen; Joseph A. Garcia; Celio X. Santos; SuWannee Thet; Eiichiro Mori; Michael T. Kinter; Paul M. Rindler; Serena Zacchigna; Shibani Mukherjee; David J. Chen; Ahmed I. Mahmoud; Mauro Giacca; Peter S. Rabinovitch; Asaithamby Aroumougame; Ajay M. Shah; Luke I. Szweda; Hesham A. Sadek
CELL, 157(3), 565-579, Apr. 2014, Refereed
Lead


- Generation and characterization of Tbx1-AmCyan1 transgenic reporter mouse line that selectively labels developing thymus primordium
Wataru Kimura; Mohammad Tofael Kabir Sharkar; Nishat Sultana; Mohammod Johirul Islam; Tadayoshi Uezato; Naoyuki Miura
TRANSGENIC RESEARCH, 22(3), 659-666, Jun. 2013, Refereed
Lead


- The cardiac hypoxic niche: emerging role of hypoxic microenvironment in cardiac progenitors.
Kimura, W; Sadek, H. A
Cardiovasc. Diagn. Ther., 2, 278-289, Dec. 2012, Refereed, Invited
Lead - Liver tumor formation by a mutant retinoblastoma protein in the transgenic mice is caused by an upregulation of c-Myc target genes
Bo Wang; Keisuke Hikosaka; Nishat Sultana; Mohammad Tofael Kabir Sharkar; Hidenao Noritake; Wataru Kimura; Yi-Xin Wu; Yoshimasa Kobayashi; Tadayoshi Uezato; Naoyuki Miura
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 417(1), 601-606, Jan. 2012, Refereed


- Expression of human factors CD81, claudin-1, scavenger receptor, and occludin in mouse hepatocytes does not confer susceptibility to HCV entry
Keisuke Hikosaka; Hidenao Noritake; Wataru Kimura; Nishat Sultana; Mohammad T. K. Sharkar; Yoh-ichi Tagawa; Tadayoshi Uezato; Yoshimasa Kobayashi; Takaji Wakita; Naoyuki Miura
BIOMEDICAL RESEARCH-TOKYO, 32(2), 143-150, Apr. 2011, Refereed


- Irxl1 Mutant Mice Show Reduced Tendon Differentiation and No Patterning Defects in Musculoskeletal System Development
Wataru Kimura; Masashi Machii; XiaoDong Xue; Nishat Sultana; Keisuke Hikosaka; Mohammad T. K. Sharkar; Tadayoshi Uezato; Masashi Matsuda; Haruhiko Koseki; Naoyuki Miura
GENESIS, 49(1), 2-9, Jan. 2011, Refereed
Lead


- The medaka FoxP2, a homologue of human language gene FOXP2, has a diverged structure and function
Tatsuo Itakura; Abhishek Chandra; Zhi Yang; XiaoDong Xue; Bo Wang; Wataru Kimura; Keisuke Hikosaka; Keiji Inohaya; Akira Kudo; Tadayoshi Uezato; Naoyuki Miura
JOURNAL OF BIOCHEMISTRY, 143(3), 407-416, Mar. 2008, Refereed


MISC
- The Loss of Foxc2 Expression in the Outflow Tract Links the Interrupted Arch in the Conditional Foxc2 Knockout Mouse
Mohammad Khaja Mafij Uddin; Wataru Kimura; Mohammed Badrul Amin; Kasumi Nakamura; Mohammod Johirul Islam; Hiroyuki Yamagishi; Naoyuki Miura
Etiology and Morphogenesis of Congenital Heart Disease, 211 - 213, 2016
http://link.springer.com/content/pdf/10.1007/978-4-431-54628-3_27

Lectures, oral presentations, etc.
- 哺乳類新生仔を用いた心筋再生の研究
木村航
第22回日本再生医療学会総会, Mar. 2023, InvitedMetabolic Regulation of Cardiac Regeneration
Wataru Kimura
RIKEN BDR Symposium 2023, Mar. 2023Mammalian interspecies comparison identifies AMPK as a postnatal cardiomyocyte cell cycle regulator
Wataru Kimura
CVMW2022 第6回日本循環器学会基礎研究フォーラム, Dec. 2022, Invitedマウス・オポッサム間比較による出生後の心筋成長スイッチング機構の解明
木村航
第95回日本生化学会大会, Nov. 2022哺乳類種間比較による新生仔心筋再生機構の同定
木村航
第51回日本新脈管作動物質学会総会, Jul. 2022, InvitedProlonged regenerative capacity in the neonatal opossum heart
Wataru Kimrua
BCVS Scientific Session 2022, Jul. 2022, Invitedマウス vs 有袋類オポッサムの比較による心筋再生機構の解明
木村航
55th annual meeting of the Japanese society of developmental biology, May 2022, Invited心筋再生研究とイメージング
木村航
極みシンポジウム, Mar. 2022, InvitedHypoxia signaling in cardiomyocyte cell cycle regulation
Wataru Kimura
第86回日本循環器学会学術総会, Mar. 2022, InvitedMetabolic Regulation of Neonatal Cardiac Regeneration
Wataru Kimura
38th ISHR, Dec. 2021, Invited出生による心筋再生スイッチングの哺乳類種間差
木村航
第94回日本生化学会大会, Nov. 2021, InvitedMetabolic Adaptation and Cardiac Regeneration
Wataru Kimura
37th ISHR, Mar. 2021, InvitedMetabolic regulation of cardiomyocyte turnover
Wataru Kimura
37th ISHR, Mar. 2021, InvitedMetabolic adaptation in the regulation of cardiomyocyte cell cycle ~how mammals deal with a mismatch between development and birth timing?
Wataru Kimura
The 51th NIPS International Symposium, Dec. 2020, InvitedOxidative metabolism in cardiomyocyte cell cycle regulation
Wataru Kimura
第4回日本循環器学会基礎研究フォーラム, Sep. 2020, InvitedOxidative Metabolism and Myocardial Homeostasis
Wataru Kimura
CVMW2019, Dec. 2019, InvitedOxidative Metabolism and Cardiomyocyte Cell Cycle Regulation
Wataru Kimura
The 50th NIPS International Symposium, Dec. 2019, InvitedEnvironmental Stress and Myocardial Regeneration
Wataru Kimura
第42回日本分子生物学会年会, Dec. 2019酸化ストレス応答と心筋再生
木村 航
第17回レドックスライフイノベーションシンポジウム, Aug. 2019, Invited環境ストレスと心筋ターンオーバー
木村 航
第28回日本Cell Death学会学術集会, Jul. 2019, Invited環境応答と心臓再生
木村航
徳島大学大学院特別講義, Jun. 2019, InvitedHeart Regeneration: lessons from phylogeny & ontogeny
Kimura Wataru
The 1st ASUKA Symposium, Jun. 2019, Invited環境応答と心臓再生能
木村 航
第17回幹細胞シンポジウム, May 2019, Invited酸化ストレス応答と心筋恒常性維持機構
木村 航
公開シンポジウム 生物は加齢とともにどのように変化するのか:最先端研究から見えてきたもの, Mar. 2019, Invited環境応答と心臓再生能
木村 航
新潟分子心血管セミナー, Feb. 2019, Invited酸化ストレス応答と心筋再生
木村 航
大阪大学循環器内科学セミナー, May 2018, InvitedDNA損傷応答による心筋細胞周期制御と心臓再生能
木村 航
千里ライフサイエンスセミナー 老化メカニズムと疾患制御, May 2018, Invited酸化的代謝と心筋再生
木村 航
山口循環器セミナー, Apr. 2018, InvitedOxidative Metabolism and Myocardial Regeneration
Kimura Wataru
基礎と臨床から循環器疾患を考える会, Mar. 2018, InvitedOxygen Metabolism and Myocardial Regeneration
Kimura Wataru
Consortium of Biological Sciences 2017, Dec. 2017, InvitedOxygen Metabolism and Cardiac Regeneration
Kimura Wataru
Jichi Medical University, May 2017, InvitedOxygen Metabolism and Cardiac Regeneration
Kimura Wataru
Keio University, May 2017, InvitedHypoxic Metabolism and Cardiac Regeneration
Kimura Wataru
The 89th Annual Meeting of the Japanese Biochemical Society, Sep. 2016, InvitedOxygen Metabolism and Cardiomyocyte Cell Cycle Regulation
Kimura Wataru
9th SYMPHONY, Sep. 2016, InvitedOxygen Metabolism and Cardiac Regeneration
Kimura Wataru
TARA/TSMM Seminar, Sep. 2016, InvitedOxygen Metabolism and Cardiac Regeneration
Kimura Wataru
7th Molecular Cardiovascular Conference II, Sep. 2016, Invited酸素代謝と心筋の細胞周期制御
木村 航
第14回日本心臓血管発生研究会, Dec. 2015, InvitedOxidative Stress and Cell Cycle Regulation in Cardiomyocytes
Wataru Kimura; Hesham A. Sadeli
Tsukuba Global Science Week 2015, Sep. 2015, InvitedOxygen Metabolism and Cardiomyocyte Proliferation.
Kimura Wataru
The Oxford Stem Cell Institute Seminar Series, Oct. 2014, InvitedTbx1-AmCyan1蛍光トランスジェニックマウスを用いた心大血管形成におけるTbx1発現細胞の解析
木村航; Sultana, N; Sharkar, TK; 彦坂圭介; 三浦直行
第33回日本分子生物学会年会, Dec. 2010, InvitedResearch Themes
- 核内RNA顆粒を介した代謝制御による心筋再生
科学研究費助成事業, 日本学術振興会, 基盤研究(B)
国立研究開発法人理化学研究所
01 Apr. 2026 - 31 Mar. 2029 - Overcoming Diabetic Retinopathy through Local Control of Oxidative Stress
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Meiji Pharmaceutical University
01 Apr. 2024 - 31 Mar. 2027 - ミトコンドリアと細胞周期のクロストーク制御による心筋再生
科学研究費助成事業, 日本学術振興会, 基盤研究(B)
国立研究開発法人理化学研究所
01 Apr. 2023 - 31 Mar. 2026 - 心筋の代謝と再生をつなぐメカニズムの解明
戦略的な研究開発の推進 創発的研究支援事業, 科学技術振興機構
理化学研究所生命機能科学研究センター
2022 - 2028 - Mechanism of Cardiac Regeneration and Developmental Heterochrony
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Research (Pioneering)
Institute of Physical and Chemical Research
09 Jul. 2021 - 31 Mar. 2024 - Mechanism of cardiomyocyte cell cycle regulation through stress response pathways
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
Institute of Physical and Chemical Research
01 Apr. 2020 - 31 Mar. 2023 - Fatty acid metabolism and cardiomyocyte cell cycle regulation
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Research (Exploratory)
Institute of Physical and Chemical Research
28 Jun. 2019 - 31 Mar. 2021 - Hypoxia Signaling and Cardiac Regeneration
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (A)
Institute of Physical and Chemical Research
01 Apr. 2017 - 31 Mar. 2020