
OHKANDA Junko
Academic Assembly School of Science and Technology Institute of Agriculture
Faculty of Agriculture Department of Agricultural and Life Sciences Division of Bioscience and Biotechnology
Professor
Researcher Information
Research Keyword
- protein-protein interactions, 14-3-3 proteins, Antitumor agents, fusicoccin, intrinsically disordered proteins and regions, Natural products, Peptides, Pharmaceutical and plant hormones, Posttranslational modification, Signaling pathways
Mail Address
- johkanda★shinshu-u.ac.jp
Career
- 2022
Chemistry A European Journal, Editorial board member (Wiley-VCH) - 2017
Bioorganic Chemistry Editorial board member (Elsevier) - 2016
Professor, Shinshu University - 2013 - 2016
Associate Professor, ICR, Kyoto University - 2005 - 2013
Associate Professor, ISIR, Osaka University - 2004 - 2005
Lecturer, Tokyo Gakugei University - 2003 - 2003
Researcher, Achillion Pharmaceuticals, Inc. (Connecticut, USA) - 1998 - 2003
Postdoctral Associate, Department of Chemistry, Yale University - 1991 - 1997
Assistant Professor, Seikei University - 1990 - 1991
Researcher, Ricoh Co. Ltd.
Research activity information
Paper
- Design and evaluation of bivalent K-Ras inhibitors that target the CAAX binding site and the acidic surface of farnesyltransferase and geranylgeranyltransferase I
Naomi Horiuchi, Rania Omer, Fumitoshi Sugino, Nanami Ogino, Yoshihisa Inoue, Kazi Aslamuzzaman, Takeyuki Suzuki, Said M. Sebti, Junko Ohkanda
Chem. Eur. J., 31, e202500306, 2025, Refereed
Last, Corresponding - Plasma membrane H+-ATPase activation increases global transcript levels and promotes the shoot growth of lightgrown Arabidopsis seedlings
Satoru N. Kinoshita, Kyomi Taki, Fumika Okamoto, Mika Nomoto, Koji Takahashi, Yuki Hayashi, Junko Ohkanda, Yasuomi Tada, Iris Finkemeier, Toshinori Kinoshita
Plant J., 121, e70034., 2025, Refereed
Last, Corresponding - Fungal toxin fusicoccin enhances plant growth by upregulating 14-3-3 interaction with plasma membrane H+-ATPase
Hironaru Kiriyama, Satoru N. Kinoshita, Yuki Hayashi, Rikako Honda, Shigemitsu Kasuga, Toshinori Kinoshita, Hiroki Irieda & Junko Ohkanda
Scientific Reports, Oct. 2024, Refereed
Last, Corresponding - Functional evaluation of an electrophilic focused library to identify a covalent inhibitor against intrinsically disordered circadian clock transcription factors
Kazuya Yamanaka, Yoshihisa Inoue, Miki Imanishi, Junko Ohkanda
Bioorganic & Medicinal Chemistry Letters, 98, Jan. 2024, Refereed
Last, Corresponding - Structure-activity-relationship study of semi-synthetically modified fusicoccins on their stabilization effect for 14-3-3 phoospholigand interactions
Nanami Ogino, Ryoma Masuda, LouvyLynn Punzalan, Emi Yamashita, Shota Igaue, Yoshihisa Inoue, Junko Ohkanda
Bioorg. Med. Chem., 73, 117020, 18 Sep. 2022, Refereed
Last, Corresponding - Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY
Ninako Kimura, Kanako Saito, Takashi Niwa, Masato Yamakawa, Shota Igaue, Junko Ohkanda, Takamitsu Hosoya, Isao Kii
Protein Expr. Purif., 196-196, 106089, 18 Mar. 2022, Refereed
Last, Corresponding - A Guanidyl-Based Bivalent Peptidomimetic Inhibits K-Ras Prenylation and Association with c-Raf
Tsubamoto, Mai; Toan Khanh Le; Li, Minghua; Watanabe, Taku; Matsumi, Chiemi; Parvatkar, Prakash; Fujii, Hiroshi; Kato, Nobuo; Sun, Jiazhi; Ohkanda, Junko;
CHEMISTRY-A EUROPEAN JOURNAL, 25(59), 13531-13536, 2019 - Structural Effects of Fusicoccin upon Upregulation of 14-3-3-Phospholigand Interaction and Cytotoxic Activity
Ohkanda, Junko; Kusumoto, Atsushi; Punzalan, Louvy; Masuda, Ryoma; Wang, Chenyu; Parvatkar, Prakash; Akase, Dai; Aida, Misako; Uesugi, Motonari; Higuchi, Yusuke; Kato, Nobuo;
CHEMISTRY-A EUROPEAN JOURNAL, 24(60), 16066-16071, 2018 - Protein-guided self-assembly for controlling protein-protein interactions
Junko Ohkanda
Journal of the Society of Japanese Women Scientists, 17, 1-7, 2017, Refereed
Last, Corresponding - Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers
Molzan, Manuela; Kasper, Stefan; Roeglin, Lars; Skwarczynska, Malgorzata; Sassa, Takeshi; Inoue, Takatsugu; Breitenbuecher, Frank; Ohkanda, Junko; Kato, Nobuo; Schuler, Martin; Ottmann, Christian;
ACS Chemical Biology, 8(9), 1869-1875, Sep. 2013, Refereed
Last, Corresponding - A Semisynthetic Fusicoccane Stabilizes a Protein-Protein Interaction and Enhances the Expression of K+ Channels at the Cell Surface
Anders, Carolin; Higuchi, Yusuke; Koschinsky, Kristin; Bartel, Maria; Schumacher, Benjamin; Thiel, Philipp; Nitta, Hajime; Preisig-Mueller, Regina; Schlichthoerl, Guenter; Renigunta, Vijay; Ohkanda, Junko; Daut, Juergen; Kato, Nobuo; Ottmann, Christian;
CHEMISTRY & BIOLOGY, 20(4), 583-593, 2013, Refereed
Last, Corresponding - A Novel Fusicoccin Derivative Preferentially Targets Hypoxic Tumor Cells and Inhibits Tumor Growth in Xenografts
Kawakami, Koshi; Hattori, Miho; Inoue, Takatsugu; Maruyama, Yuriko; Ohkanda, Junko; Kato, Nobuo; Tongu, Miki; Yamada, Takaya; Akimoto, Miho; Takenaga, Keizo; Sassa, Takeshi; Suzumiy, Junji; Honma, Yoshio;
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 12(7), 791-800, Sep. 2012, Refereed
Last, Corresponding - Transannular Proton Transfer in the Cyclization of Geranylgeranyl Diphosphate to Fusicoccadiene, a Biosynthetic Intermediate of Fusicoccins
Toyomasu, Tomonobu; Tsukahara, Mai; Kenmoku, Hiromichi; Anada, Masahide; Nitta, Hajime; Ohkanda, Junko; Mitsuhashi, Wataru; Sassa, Takeshi; Kato, Nobuo;
ORGANIC LETTERS, 11(14), 3044-3047, 2009, Refereed
Last, Corresponding - Structurally Simple Inhibitors of Lanosterol 14 alpha-Demethylase Are Efficacious In a Rodent Model of Acute Chagas Disease
Suryadevara, Praveen Kumar; Olepu, Srinivas; Lockman, Jeffrey W.; Ohkanda, Junko; Karimi, Mandana; Verlinde, Christophe L. M. J.; Kraus, James M.; Schoepe, Jan; Van Voorhis, Wesley C.; Hamilton, Andrew D.; Buckner, Frederick S.; Gelb, Michael H.;
JOURNAL OF MEDICINAL CHEMISTRY, 52(12), 3703-3715, 2009, Refereed
Last, Corresponding - Module assembly for protein-surface recognition: Geranylgeranyltransferase I bivalent inhibitors for simultaneous targeting of interior and exterior protein surfaces
Machida, Shinnosuke; Usuba, Kakeru; Blaskovich, Michelle A.; Yano, Akiko; Harada, Kazuo; Sebti, Said M.; Kato, Nobuo; Ohkanda, Junko;
CHEMISTRY-A EUROPEAN JOURNAL, 14(5), 1392-1401, 2008, Refereed
Last, Corresponding - Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter
Delarue, F. L.; Adnane, J.; Joshi, B.; Blaskovich, M. A.; Wang, D-A; Hawker, J.; Bizouarn, F.; Ohkanda, J.; Zhu, K.; Hamilton, A. D.; Chellappan, S.; Sebti, S. M.;
Oncogene, 26(5), 633-640, Feb. 2007 - ORGN 129-Bivalent inhibitors of Type-I geranylgeranyltransferase for simultaneous recognition of interior and exterior protein surfaces
Ohkanda, Junko; Machida, Shinnosuke; Kato, Nobuo; Blaskovich, Michelle A.; Sebti, Saied M.; Harada, Kazuo;
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 234, 2007 - Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase
Ohkanda, J; Strickland, CL; Blaskovich, MA; Carrico, D; Lockman, JW; Vogt, A; Bucher, CJ; Sun, JZ; Qian, YM; Knowles, D; Pusateri, EE; Sebti, SM; Hamilton, AD;
Organic & Biomolecular Chemistry, 4(3), 482-492, 2006 - In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability
Carrico, D; Ohkanda, J; Kendrick, H; Yokoyama, K; Blaskovich, MA; Bucher, CJ; Buckner, FS; Van Voorhis, WC; Chakrabarti, D; Croft, SL; Gelb, MH; Sebti, SM; Hamilton, AD;
Bioorganic & medicinal chemistry, 12(24), 6517-6526, 2004 - Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents
Ohkanda, J; Buckner, FS; Lockman, JW; Yokoyama, K; Carrico, D; Eastman, R; de Luca-Fradley, K; Davies, W; Croft, SL; Van Voorhis, WC; Gelb, MH; Sebti, SM; Hamilton, AD;
JOURNAL OF MEDICINAL CHEMISTRY, 47(2), 432-445, 2004 - A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents
Buckner, F; Yokoyama, K; Lockman, J; Aikenhead, K; Ohkanda, J; Sadilek, M; Sebti, S; Van Voorhis, W; Hamilton, A; Gelb, MH;
Proceedings of the National Academy of Sciences of the United States of America, 100(25), 15149-15153, 2003 - Prenyltransferase inhibitors as antitumor and antiparasitic agents: Rational design based on CAAX peptide and solution phase combinatorial approaches.
Ohkanda, J; Lockman, JW; Carrico, D; Strickland, CL; Sebti, SM; Gelb, MH; Hamilton, AD;
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 224, U30-U30, 2002 - Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine
Sun, JZ; Blaskovich, MA; Knowles, D; Qian, YM; Ohkanda, J; Bailey, RD; Hamilton, AD; Sebti, SM;
CANCER RESEARCH, 59(19), 4919-4926, 1999 - New hexadentate ligands composed of 1-hydroxy-2(1H)-pyrimidinone, alpha,omega-diamine and 1,1,1-tris(carboxyethoxymethyl)-ethane or tri(carboxybutyl)isocyanurate. Synthesis and characterization of their iron(III) complexes
Katoh, A; Hida, Y; Kamitani, J; Ohkanda, J;
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, (22), 3859-3864, 1998 - Requirement for geranylgeranyl transferase I and acyl transferase in the TGF-beta-stimulated pathway leading to elastin mRNA stabilization
Kucich, U; Rosenbloom, JC; Shen, G; Abrams, WR; Blaskovich, MA; Hamilton, AD; Ohkanda, J; Sebti, SM; Rosenbloom, J;
Biochemical and biophysical research communications, 252(1), 111-116, 1998 - Novel iron sequestering agents: Synthesis and iron-chelating properties of hexadentate ligands composed of 1-hydroxy-2(1H)-pyrimidinone, omega-amino carboxylic acid, and tris(2-aminoethyl)amine
Ohkanda, J; Kamitani, J; Tokumitsu, T; Hida, Y; Konakahara, T; Katoh, A;
JOURNAL OF ORGANIC CHEMISTRY, 62(11), 3618-3624, 1997
Books and other publications
- Chemical approach toward controlling of transient protein interactions, published in Middle Molecular Strategy
Junko Ohkanda, Chemical approach toward controlling of transient protein interactions
Springer, Singapore, 77-96 14 Jul. 2021
ISBN:978-981-16-2457-5Self-assembled receptors for protein surface recognition, published in Comprehensive Supramolecular Chemistry II
Junko Ohkanda, Self-Assembled Receptors for Protein Surface Recognition
Elsevier, Oxford, 351-369 2017Affiliated academic society