Chemical Biology

Chemical biology, Bioorganic chemistry

2022
Chemistry A European Journal, Editorial board member (Wiley-VCH)

2017
Bioorganic Chemistry Editorial board member (Elsevier)

2016
Professor, Shinshu University

2013 - 2016
Associate Professor, ICR, Kyoto University

2005 - 2013
Associate Professor, ISIR, Osaka University

2004 - 2005
Lecturer, Tokyo Gakugei University

2003 - 2003
Researcher, Achillion Pharmaceuticals, Inc. (Connecticut, USA)

1998 - 2003
Postdoctral Associate, Department of Chemistry, Yale University

1991 - 1997
Assistant Professor, Seikei University

1990 - 1991
Researcher, Ricoh Co. Ltd.

1990, M. Sc., Ochanomizu University

2022
Scientific Program Committee, International Chemical Biology Society

2017
公益財団法人 長瀬科学技術振興財団, Nagase Foundation Research Award

Diterpene molecular glue stabilizes protein-protein interactions of disordered phosphoprotein that controls translational repression
Nanami Ogino, Ryoma Masuda, Shota Igaue, Mei Arita, Ami Matsumura, Yumi Ieda, Makoto Muroi, Ken Matsumoto, Reiko Nakagawa, Yusuke Higuchi, Hiroyuki Osada, Minoru Yoshida, Isao Kii, Junko Ohkanda
JACS Au, 6, 973-985, 2026, Refereed
Last, Corresponding

Design and evaluation of bivalent K-Ras inhibitors that target the CAAX binding site and the acidic surface of farnesyltransferase and geranylgeranyltransferase I
Naomi Horiuchi, Rania Omer, Fumitoshi Sugino, Nanami Ogino, Yoshihisa Inoue, Kazi Aslamuzzaman, Takeyuki Suzuki, Said M. Sebti, Junko Ohkanda
Chem. Eur. J., 31, e202500306, 2025, Refereed
Last, Corresponding

Plasma membrane H+-ATPase activation increases global transcript levels and promotes the shoot growth of lightgrown Arabidopsis seedlings
Satoru N. Kinoshita, Kyomi Taki, Fumika Okamoto, Mika Nomoto, Koji Takahashi, Yuki Hayashi, Junko Ohkanda, Yasuomi Tada, Iris Finkemeier, Toshinori Kinoshita
Plant J., 121, e70034., 2025, Refereed
Last, Corresponding

Fungal toxin fusicoccin enhances plant growth by upregulating 14-3-3 interaction with plasma membrane H+-ATPase
Hironaru Kiriyama, Satoru N. Kinoshita, Yuki Hayashi, Rikako Honda, Shigemitsu Kasuga, Toshinori Kinoshita, Hiroki Irieda & Junko Ohkanda
Scientific Reports, Oct. 2024, Refereed
Last, Corresponding

Functional evaluation of an electrophilic focused library to identify a covalent inhibitor against intrinsically disordered circadian clock transcription factors
Kazuya Yamanaka, Yoshihisa Inoue, Miki Imanishi, Junko Ohkanda
Bioorganic & Medicinal Chemistry Letters, 98, Jan. 2024, Refereed
Last, Corresponding

Isoform-selective fluorescent labeling of 14-3-3sigma by acrylamide-containing fusicoccins
Kenta Tanaka, Yoshiya Hatano, Junko Ohkanda
Chemistry A European Journal, 29(41), Jul. 2023, Refereed
Last, Corresponding

Structure-activity-relationship study of semi-synthetically modified fusicoccins on their stabilization effect for 14-3-3 phoospholigand interactions
Nanami Ogino, Ryoma Masuda, LouvyLynn Punzalan, Emi Yamashita, Shota Igaue, Yoshihisa Inoue, Junko Ohkanda
Bioorg. Med. Chem., 73, 117020, 18 Sep. 2022, Refereed
Last, Corresponding

Expression and purification of DYRK1A kinase domain in complex with its folding intermediate-selective inhibitor FINDY
Ninako Kimura, Kanako Saito, Takashi Niwa, Masato Yamakawa, Shota Igaue, Junko Ohkanda, Takamitsu Hosoya, Isao Kii
Protein Expr. Purif., 196-196, 106089, 18 Mar. 2022, Refereed
Last, Corresponding

Design, synthesis, and functional evaluation of triazine-based bivalent agents that simultaneously target the active site and hot spot of phosphatase Cdc25B
Yosei Nagaoka, Prakash Parvatkar, Go Hirai, Junko Ohkanda
Bioorg. Med. Chem. Lett., 48, 128265, 12 Jul. 2021, Refereed
Last, Corresponding

Intrinsically Disordered Proteins as Regulators of Transient Biological Processes and as Untapped Drug Targets
Hosoya, Yusuke; Ohkanda, Junko;
MOLECULES, 26(8), Apr. 2021
Last, Corresponding

Fusicoccin: A Chemical Modulator for 14-3-3 Proteins
Ohkanda, Junko;
Chemistry Letters, 50(1), 57-67, Jan. 2021
Lead, Corresponding

Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors
Yusuke Hosoya, Wataru Nojo, Isao Kii, Takanori Suzuki, Miki Imanishi, Junko Ohkanda
Chemical Communications, 56, 11203-11206, 21 Aug. 2020, Refereed
Last, Corresponding

Copper-Free Huisgen Cycloaddition for the 14-3-3-Templated Synthesis of Fusicoccin-Peptide Conjugates
Masuda, Ryoma; Kawasaki, Yuuya; Igawa, Kazunobu; Manabe, Yoshiyuki; Fujii, Hiroshi; Kato, Nobuo; Tomooka, Katsuhiko; Ohkanda, Junko;
CHEMISTRY-AN ASIAN JOURNAL, 15, 742-747, 2020
Corresponding

A NOVEL CONDENSED HETEROCYCLIC QUINONE WITH A DIBENZOFURANOBISTHIADIAZOLE SKELETON
Sugawara, Kazuma; Nojo, Wataru; Ishigaki, Yusuke; Ohkanda, Junko; Suzuki, Takanori;
Heterocycles, 101(1), 99-103, 2020

Dipicolylamine/Metal Complexes that Promote Direct Cell-Membrane Penetration of Octaarginine
Kawaguchi, Yoshimasa; Ise, Shoko; Azuma, Yusuke; Takeuchi, Toshihide; Kawano, Kenichi; Toan Khanh Le; Ohkanda, Junko; Futaki, Shiroh;
Bioconjugate chemistry, 30(2), 454-460, Feb. 2019

A Guanidyl-Based Bivalent Peptidomimetic Inhibits K-Ras Prenylation and Association with c-Raf
Tsubamoto, Mai; Toan Khanh Le; Li, Minghua; Watanabe, Taku; Matsumi, Chiemi; Parvatkar, Prakash; Fujii, Hiroshi; Kato, Nobuo; Sun, Jiazhi; Ohkanda, Junko;
CHEMISTRY-A EUROPEAN JOURNAL, 25(59), 13531-13536, 2019
Corresponding

Structural Effects of Fusicoccin upon Upregulation of 14-3-3-Phospholigand Interaction and Cytotoxic Activity
Ohkanda, Junko; Kusumoto, Atsushi; Punzalan, Louvy; Masuda, Ryoma; Wang, Chenyu; Parvatkar, Prakash; Akase, Dai; Aida, Misako; Uesugi, Motonari; Higuchi, Yusuke; Kato, Nobuo;
CHEMISTRY-A EUROPEAN JOURNAL, 24(60), 16066-16071, 2018
Lead, Corresponding

A Strategy of Designing Mid-sized Synthetic Molecules that Recognize Interfaces of Protein protein Interactions
Ohkanda, Junko;
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 75(7), 735-745, Jul. 2017

たんぱく質間相互作用を制御する合成分子の創製
大神田 淳子;
京都大学化学研究所スーパーコンピュータシステム研究成果報告書, 2016, 7-7, Mar. 2017

Protein-guided self-assembly for controlling protein-protein interactions
Junko Ohkanda
Journal of the Society of Japanese Women Scientists, 17, 1-7, 2017, Refereed
Last, Corresponding

Intracellular Generation of a Diterpene-Peptide Conjugate that Inhibits 14-3-3-Mediated Interactions
Parvatkar, Prakash; Kato, Nobuo; Uesugi, Motonari; Sato, Shin-ichi; Ohkanda, Junko;*
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137(50), 15624-15627, 2015, Refereed
Last, Corresponding

RNA-Directed Amino Acid Coupling as a Model Reaction for Primitive Coded Translation
Harada, Kazuo*; Aoyama, Shoko; Matsugami, Akimasa; Kumar, Penmetcha K. R.; Katahira, Masato; Kato, Nobuo; Ohkanda, Junko;
ChemBioChem, 15(6), 794-798, 2014, Refereed
Last, Corresponding

Module Assembly for Designing Multivalent Mid-Sized Inhibitors of Protein-Protein Interactions
Ohkanda, Junko;*
CHEMICAL RECORD, 13(6), 561-575, Dec. 2013, Refereed
Lead, Last, Corresponding

Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers
Molzan, Manuela; Kasper, Stefan; Roeglin, Lars; Skwarczynska, Malgorzata; Sassa, Takeshi; Inoue, Takatsugu; Breitenbuecher, Frank; Ohkanda, Junko; Kato, Nobuo; Schuler, Martin; Ottmann, Christian;
ACS Chemical Biology, 8(9), 1869-1875, Sep. 2013, Refereed
Last, Corresponding

Peptidomimetic modification improves cell permeation of bivalent farnesyltransferase inhibitors
Machida, Shinnosuke; Tsubamoto, Mai; Kato, Nobuo; Harada, Kazuo; Ohkanda, Junko;
Bioorganic & medicinal chemistry, 21(14), 4004-4010, 2013, Refereed
Last, Corresponding

A Semisynthetic Fusicoccane Stabilizes a Protein-Protein Interaction and Enhances the Expression of K+ Channels at the Cell Surface
Anders, Carolin; Higuchi, Yusuke; Koschinsky, Kristin; Bartel, Maria; Schumacher, Benjamin; Thiel, Philipp; Nitta, Hajime; Preisig-Mueller, Regina; Schlichthoerl, Guenter; Renigunta, Vijay; Ohkanda, Junko; Daut, Juergen; Kato, Nobuo; Ottmann, Christian;
CHEMISTRY & BIOLOGY, 20(4), 583-593, 2013, Refereed
Last, Corresponding

Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase
Hayashi, Daisuke; Kato, Nobuo; Kuzuyama, Tomohisa; Sato, Yasuo; Ohkanda, Junko;*
Chemical Communications, 49(49), 5535-5537, 2013, Refereed
Last, Corresponding

Chemical ligation of epoxide-containing fusicoccins and peptide fragments guided by 14-3-3 protein
Maki, Toshio; Kawamura, Akie; Kato, Nobuo; Ohkanda, Junko;*
MOLECULAR BIOSYSTEMS, 9(5), 940-943, 2013, Refereed
Last, Corresponding

A Novel Fusicoccin Derivative Preferentially Targets Hypoxic Tumor Cells and Inhibits Tumor Growth in Xenografts
Kawakami, Koshi; Hattori, Miho; Inoue, Takatsugu; Maruyama, Yuriko; Ohkanda, Junko; Kato, Nobuo; Tongu, Miki; Yamada, Takaya; Akimoto, Miho; Takenaga, Keizo; Sassa, Takeshi; Suzumiy, Junji; Honma, Yoshio;
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 12(7), 791-800, Sep. 2012, Refereed
Last, Corresponding

Protein recognition of hetero-/homoleptic ruthenium(II) tris(bipyridine)s for alpha-chymotrypsin and cytochrome c
Yamaguchi, Yoshinobu; Kato, Nobuo; Azuma, Hideki; Nagasaki, Takeshi; Ohkanda, Junko;*
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22(6), 2354-2358, 2012, Refereed
Last, Corresponding

Phosphopeptide-Dependent Labeling of 14-3-3 zeta Proteins by Fusicoccin-Based Fluorescent Probes
Takahashi, Michiko; Kawamura, Akie; Kato, Nobuo; Nishi, Tsuyoshi; Hamachi, Itaru; Ohkanda, Junko;*
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(2), 509-512, 2012, Refereed
Last, Corresponding

Bivalent Inhibitors for Disrupting Protein Surface-Substrate Interactions and for Dual Inhibition of Protein Prenyltransferases
Machida, Shinnosuke; Kato, Nobuo; Harada, Kazuo; Ohkanda, Junko;*
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133(4), 958-963, 2011, Refereed
Last, Corresponding

Design and functional evaluation of dual prenyltransferase inhibitors for simultaneous recognition of active site and exterior protein surface
Machida, Shinnosuke; Kato, Nobuo; Harada, Kazuo; Ohkanda, Junko;
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 238, 2009, Refereed
Last, Corresponding

Transannular Proton Transfer in the Cyclization of Geranylgeranyl Diphosphate to Fusicoccadiene, a Biosynthetic Intermediate of Fusicoccins
Toyomasu, Tomonobu; Tsukahara, Mai; Kenmoku, Hiromichi; Anada, Masahide; Nitta, Hajime; Ohkanda, Junko; Mitsuhashi, Wataru; Sassa, Takeshi; Kato, Nobuo;
ORGANIC LETTERS, 11(14), 3044-3047, 2009, Refereed
Last, Corresponding

Structurally Simple Inhibitors of Lanosterol 14 alpha-Demethylase Are Efficacious In a Rodent Model of Acute Chagas Disease
Suryadevara, Praveen Kumar; Olepu, Srinivas; Lockman, Jeffrey W.; Ohkanda, Junko; Karimi, Mandana; Verlinde, Christophe L. M. J.; Kraus, James M.; Schoepe, Jan; Van Voorhis, Wesley C.; Hamilton, Andrew D.; Buckner, Frederick S.; Gelb, Michael H.;
JOURNAL OF MEDICINAL CHEMISTRY, 52(12), 3703-3715, 2009, Refereed
Last, Corresponding

Protein surface recognition by dendritic ruthenium(II) tris(bipyridine) complexes
Ohkanda, Junko; Satoh, Ritsuko; Kato, Nobuo;
Chemical Communications, (45), 6949-6951, 2009, Refereed
Lead, Last, Corresponding

Module assembly for protein-surface recognition: Geranylgeranyltransferase I bivalent inhibitors for simultaneous targeting of interior and exterior protein surfaces
Machida, Shinnosuke; Usuba, Kakeru; Blaskovich, Michelle A.; Yano, Akiko; Harada, Kazuo; Sebti, Said M.; Kato, Nobuo; Ohkanda, Junko;
CHEMISTRY-A EUROPEAN JOURNAL, 14(5), 1392-1401, 2008, Refereed
Last, Corresponding

Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter
Delarue, F. L.; Adnane, J.; Joshi, B.; Blaskovich, M. A.; Wang, D-A; Hawker, J.; Bizouarn, F.; Ohkanda, J.; Zhu, K.; Hamilton, A. D.; Chellappan, S.; Sebti, S. M.;
Oncogene, 26(5), 633-640, Feb. 2007

ORGN 129-Bivalent inhibitors of Type-I geranylgeranyltransferase for simultaneous recognition of interior and exterior protein surfaces
Ohkanda, Junko; Machida, Shinnosuke; Kato, Nobuo; Blaskovich, Michelle A.; Sebti, Saied M.; Harada, Kazuo;
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 234, 2007

Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase
Ohkanda, J; Strickland, CL; Blaskovich, MA; Carrico, D; Lockman, JW; Vogt, A; Bucher, CJ; Sun, JZ; Qian, YM; Knowles, D; Pusateri, EE; Sebti, SM; Hamilton, AD;
Organic & Biomolecular Chemistry, 4(3), 482-492, 2006

In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability
Carrico, D; Ohkanda, J; Kendrick, H; Yokoyama, K; Blaskovich, MA; Bucher, CJ; Buckner, FS; Van Voorhis, WC; Chakrabarti, D; Croft, SL; Gelb, MH; Sebti, SM; Hamilton, AD;
Bioorganic & medicinal chemistry, 12(24), 6517-6526, 2004

Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents
Ohkanda, J; Buckner, FS; Lockman, JW; Yokoyama, K; Carrico, D; Eastman, R; de Luca-Fradley, K; Davies, W; Croft, SL; Van Voorhis, WC; Gelb, MH; Sebti, SM; Hamilton, AD;
JOURNAL OF MEDICINAL CHEMISTRY, 47(2), 432-445, 2004

In vivo antiviral efficacy of prenylation inhibitors against hepatitis delta virus
Bordier, BB; Ohkanda, J; Liu, P; Lee, SY; Salazar, FH; Marion, PL; Ohashi, K; Meuse, L; Kay, MA; Casey, JL; Sebti, SM; Hamilton, AD; Glenn, JS;
JOURNAL OF CLINICAL INVESTIGATION, 112(3), 407-414, Aug. 2003

The farnesyl transferase inhibitor, FTI-277, inhibits growth and induces apoptosis in drug-resistant myeloma tumor cells
Bolick, SCE; Landowski, TH; Boulware, D; Oshiro, MM; Ohkanda, J; Hamilton, AD; Sebti, SM; Dalton, WS;
Leukemia, 17(2), 451-457, Feb. 2003

Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice
Sun, JZ; Ohkanda, J; Coppola, D; Yin, H; Kothare, M; Busciglio, B; Hamilton, AD; Sebti, SM;
CANCER RESEARCH, 63(24), 8922-8929, 2003

A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents
Buckner, F; Yokoyama, K; Lockman, J; Aikenhead, K; Ohkanda, J; Sadilek, M; Sebti, S; Van Voorhis, W; Hamilton, A; Gelb, MH;
Proceedings of the National Academy of Sciences of the United States of America, 100(25), 15149-15153, 2003

The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status
Crespo, NC; Delarue, F; Ohkanda, J; Carrico, D; Hamilton, AD; Sebti, SM;
CELL DEATH AND DIFFERENTIATION, 9(7), 702-709, Jul. 2002

CAAX peptidomimetics: Their farnesyltransferase inhibition activity and antitumor effect
Ohkanda, J;
SEIKAGAKU, 74(1), 46-50, Jan. 2002

Synthesis of linear and cyclic hexapeptides with N epsilon-(1,2-dihydro-1-hydroxy-2-oxopyrimidin-4-yl)-L-lysyl-beta-alanyl as the repeating unit and properties of their iron(III) complexes
Katoh, A; Inoue, Y; Nagashima, H; Hikita, Y; Ohkanda, J; Saito, R;
Heterocycles, 58, 371-381, 2002

Toward Chagas disease chemotherapeutics: Development of simple compounds active against Trypanosoma cruzi.
Lockman, JW; Ohkanda, J; Yokoyama, K; Eastman, RT; Buckner, FS; Gelb, MH; Hamilton, AD;
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 224, U17-U17, 2002

Design, synthesis and evaluation of peptidomimetic farnesyltransferase inhibitor ester pro-drugs as potent antiparasitic agents.
Carrico, D; Ohkanda, J; Gelb, MH; Blaskovich, MA; Sebti, SM; Hamilton, AD;
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 224, U28-U28, 2002

Prenyltransferase inhibitors as antitumor and antiparasitic agents: Rational design based on CAAX peptide and solution phase combinatorial approaches.
Ohkanda, J; Lockman, JW; Carrico, D; Strickland, CL; Sebti, SM; Gelb, MH; Hamilton, AD;
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 224, U30-U30, 2002

Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold
Ohkanda, J; Lockman, JW; Kothare, MA; Qian, YM; Blaskovich, MA; Sebti, SM; Hamilton, AD;
JOURNAL OF MEDICINAL CHEMISTRY, 45(1), 177-188, 2002

3-hydroxy-4(1H)-pyridinone-containing linear and cyclic hexapeptides and their iron(III) complexes - Synthesis, property, and the growth-promotion activity-
Katoh, A; Hikita, Y; Harata, M; Ohkanda, J; Tsubomura, T; Higuchi, A; Saito, R; Harada, K;
Heterocycles, 55(11), 2171-2187, 2001

The farnesyltransferase inhibitor, FTI-2153, blocks bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells
Crespo, NC; Ohkanda, J; Yen, TJ; Hamilton, AD; Sebti, SM;
JOURNAL OF BIOLOGICAL CHEMISTRY, 276(19), 16161-16167, 2001

Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity
Ohkanda, J; Lockman, JW; Yokoyama, K; Gelb, MH; Croft, SL; Kendrick, H; Harrell, MI; Feagin, JE; Blaskovich, MA; Sebti, SM; Hamilton, AD;
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 11(6), 761-764, 2001

Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
Lantry, LE; Zhang, ZQ; Yao, RS; Crist, KA; Wang, Y; Ohkanda, J; Hamilton, AD; Sebti, SM; Lubet, RA; You, M;
CARCINOGENESIS, 21(1), 113-116, Jan. 2000

Development of a tripeptide mimetic strategy for the inhibition of protein farnesyltransferase
Kothare, MA; Ohkanda, J; Lockman, JW; Qian, YM; Blaskovich, MA; Sebti, SM; Hamilton, AD;
Tetrahedron, 56(50), 9833-9841, 2000

Inhibition of farnesyltransferase increases TGF beta type II receptor expression and enhances the responsiveness of human cancer cells to TGF beta
Adnane, J; Bizouarn, FA; Chen, Z; Ohkanda, J; Hamilton, AD; Munoz-Antonia, T; Sebti, SM;
Oncogene, 19(48), 5525-5533, 2000

Synthesis of quinoxaline derivatives bearing the styryl and phenylethynyl groups and application to a fluorescence derivatization reagent
Katoh, A; Yoshida, T; Ohkanda, J;
Heterocycles, 52(2), 911-920, 2000

Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin, taxol, and gemcitabine
Sun, JZ; Blaskovich, MA; Knowles, D; Qian, YM; Ohkanda, J; Bailey, RD; Hamilton, AD; Sebti, SM;
CANCER RESEARCH, 59(19), 4919-4926, 1999

Novel nonthiol inhibitors of farnesyl transferase show potent antitumor properties.
Ohkanda, J; Blaskovich, M; Sun, J; Sebti, SM; Hamilton, AD;
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 218, U984-U984, 1999

Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I
Vasudevan, A; Qian, YM; Vogt, A; Blaskovich, MA; Ohkanda, J; Sebti, SM; Hamilton, AD;
JOURNAL OF MEDICINAL CHEMISTRY, 42(8), 1333-1340, 1999

Synthesis of 6-(bromoacetyl)amino-2,3-dimorpholinoquinoxaline and application to a new fluorescence derivatization reagent of fatty acids for the high-performance liquid chromatographic analysis
Katoh, A; Fujimoto, T; Takahashi, M; Ohkanda, J;
Heterocycles, 50(1), 299-308, 1999

Synthesis of 2,2 '-bipyridines bearing amino or carboxyl group at the side chain and physical properties of their ruthenium(II) complexes
Katoh, A; Kitamura, Y; Fujii, H; Horie, Y; Satoh, T; Ohkanda, J; Yokomori, Y;
Heterocycles, 49, 281-296, 1998

New hexadentate ligands composed of 1-hydroxy-2(1H)-pyrimidinone, alpha,omega-diamine and 1,1,1-tris(carboxyethoxymethyl)-ethane or tri(carboxybutyl)isocyanurate. Synthesis and characterization of their iron(III) complexes
Katoh, A; Hida, Y; Kamitani, J; Ohkanda, J;
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, (22), 3859-3864, 1998

Requirement for geranylgeranyl transferase I and acyl transferase in the TGF-beta-stimulated pathway leading to elastin mRNA stabilization
Kucich, U; Rosenbloom, JC; Shen, G; Abrams, WR; Blaskovich, MA; Hamilton, AD; Ohkanda, J; Sebti, SM; Rosenbloom, J;
Biochemical and biophysical research communications, 252(1), 111-116, 1998

N-hydroxypyrazinone-bearing homotrioxacalix[3]arene: its cooperative molecular recognition by metal complexation
Ohkanda, J; Shibui, H; Katoh, A;
Chemical Communications, (3), 375-376, 1998

N-hydroxyamide-containing heterocycles: Synthesis, reactivities, and iron(III)-chelating properties
Ohkanda, J; Katoh, A;
REVIEWS ON HETEROATOM CHEMISTRY, 18, 87-118, 1998

Functionalized N-hydroxyamide-containing heterocycles - Synthesis, reaction, and metal-chelating property
Ohkanda, J; Katoh, A;
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 55(6), 524-534, Jun. 1997

Synthesis of 1,3-linked 1,4-dihydropyridines containing the L-tyrosine residue and the influence of their structures upon the enantioselective reduction
Katoh, A; Naruse, S; Ohkanda, J; Yamamoto, H;
Heterocycles, 45(8), 1441-1446, 1997

Novel iron sequestering agents: Synthesis and iron-chelating properties of hexadentate ligands composed of 1-hydroxy-2(1H)-pyrimidinone, omega-amino carboxylic acid, and tris(2-aminoethyl)amine
Ohkanda, J; Kamitani, J; Tokumitsu, T; Hida, Y; Konakahara, T; Katoh, A;
JOURNAL OF ORGANIC CHEMISTRY, 62(11), 3618-3624, 1997

Structural analysis of N-(omega-phenylalkyl)substituted quinoxalin-2(1H)-ones and -thiones
Katoh, A; Yoshida, T; Ohkanda, J; Nishio, T;
Heterocycles, 44, 357-366, 1997

N-hydroxyamide-containing heterocycles .7. Preparation and photochemical behavior of 1-benzyloxy-2(1H)-pyrazinones
Ohkanda, J; Kumasaka, T; Takasu, A; Hasegawa, T; Katoh, A;
Heterocycles, 43(4), 883-889, 1996

Synthesis of novel amphiphilic compounds containing aza-12-crown-4 or D-glucosamine and their ion permeability
Katoh, A; Ishida, S; Ohkanda, J; Washizu, M;
Heterocycles, 43(3), 589-599, 1996

Synthesis of 2,3-disubstituted 6-aminoquinoxalines and their application to new fluorescence derivatization reagents for carboxylic acids
Katoh, A; Takahashi, M; Ohkanda, J;
Chemistry Letters, (5), 369-370, 1996

The influence of the chirality of synthetic iron chelators bearing N-hydroxy-2(1H)-pyrazinones and amino acid residues upon iron removal from human transferrin
Ohkanda, J; Katoh, A;
Chemistry Letters, (6), 423-424, 1996

N-hydroxyamide-containing heterocycles .6. Application of 1-hydroxy-4,6-dimethyl-2(1H)-pyrimidinone to a new benzyloxycarbonylating agent
Katoh, A; Kondoh, S; Ohkanda, J;
HETEROCYCLIC COMMUNICATIONS, 2(2), 141-144, 1996

N-HYDROXYAMIDE-CONTAINING HETEROCYCLES .5. SYNTHESIS OF NOVEL HEXADENTATE LIGANDS COMPOSED OF N-HYDROXY-2(1H)-PYRAZINONE, ALIPHATIC DIAMINE, AND 1,1,1-TRIS(CARBOXYETHOXYMETHYL)ETHANE, AND PROPERTIES OF THEIR FERRIC COMPLEXES
Ohkanda, J; Katoh, A;
Tetrahedron, 51(47), 12995-13002, 1995

N-HYDROXYAMIDE-CONTAINING HETEROCYCLES .4. SYNTHESIS AND FE-III-CHELATING PROPERTIES OF NOVEL HEXADENTATE LIGANDS COMPOSED OF N-HYDROXY-2(1H)-PYRAZINONE, AMINO-ACID-RESIDUES, AND TRIS(2-AMINOETHYL)AMINE
Ohkanda, J; Katoh, A;
JOURNAL OF ORGANIC CHEMISTRY, 60(6), 1583-1589, 1995

SYNTHESIS OF 2(1H)-PYRIMIDINONE-CONTAINING ALPHA-AMINO-ACID DERIVATIVES BY CHEMICAL MODIFICATION OF L-GLUTAMIC ACID
KATOH, A; INOKAWA, M; OHKANDA, J; MITSUHASHI, K;
CHEMICAL & PHARMACEUTICAL BULLETIN, 42(7), 1514-1517, Jul. 1994

N-HYDROXYAMIDE-CONTAINING HETEROCYCLES .3. THE RING TRANSFORMATION OF 1-BENZYLOXY-2(1H)-PYRIMIDINONES INTO 2-ISOXAZOLINES WITH HYDROXYLAMINE
KATOH, A; OHKANDA, J; TAMURA, A; YOSHIIKE, Y; MITSUHASHI, K;
Heterocycles, 37(2), 1141-1146, 1994

N-HYDROXYAMIDE-CONTAINING HETEROCYCLES .2. SYNTHESIS AND IRON(III) COMPLEX-FORMING TENDENCY OF 1-HYDROXY-2(1H)-PYRIMIDINONE AND 1-HYDROXY-2(1H)-PYRAZINONE
OHKANDA, J; TOKUMITSU, T; MITSUHASHI, K; KATOH, A;
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 66(3), 841-847, Mar. 1993

A CONVENIENT SYNTHESIS OF 3-(ARYL)SUBSTITUTED 2,4(1H,3H)-PTERIDINEDIONES AND THEIR ABSORPTION AND FLUORESCENCE SPECTROSCOPIC CHARACTERISTICS
KATOH, A; OHKANDA, J; SATO, H; SAKAMOTO, T; MITSUHASHI, K;
Heterocycles, 35(2), 949-954, 1993

N-HYDROXYAMIDE-CONTAINING HETEROCYCLES - NEW EFFECTIVE ADDITIVES FOR PEPTIDE-SYNTHESIS BY THE DICYCLOHEXYLCARBODIIMIDE METHOD
KATOH, A; OHKANDA, J; ITOH, Y; MITSUHASHI, K;
Chemistry Letters, (10), 2009-2012, Oct. 1992

STRUCTURAL ASPECTS OF THE MECHANICAL AND THERMAL-DISSOCIATION OF THE CENTRAL BOND IN 2,2'-BIS(2,3,4-TRIARYLCHROMENYL)S
OHKANDA, J; MORI, Y; MAEDA, K; OSAWA, E;
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, (1), 59-63, Jan. 1992

ISOLATION OF THE INTERMEDIATES AND IMPROVED SYNTHESIS OF PYRIDO[1',2'/1,2]IMIDAZOL[4,5-B]PYRAZINES AND PYRIDO[1',2'/1,2]IMIDAZOL]4,5-B]QUINOXALINES
KATOH, A; UEDA, SH; OHKANDA, J; HIROTA, M; KOMINE, H; MITSUHASHI, K;
Heterocycles, 34(10), 1965-1972, 1992

UNUSUAL SUBSTITUENT EFFECT BY THE ALPHA-ACETYL GROUP ON THE TYPE-II PHOTOREACTION OF VALEROPHENONES - STRONG WAVELENGTH DEPENDENCE OF QUANTUM YIELDS
HASEGAWA, T; OHKANDA, J; KOBAYASHI, M; YOSHIOKA, M;
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 64(3), 299-306, 1992

Chemical approach toward controlling of transient protein interactions, published in Middle Molecular Strategy
Junko Ohkanda, Contributor, Chemical approach toward controlling of transient protein interactions
Springer, Singapore, 77-96 14 Jul. 2021, Refereed
ISBN:978-981-16-2457-5

Self-assembled receptors for protein surface recognition, published in Comprehensive Supramolecular Chemistry II
Junko Ohkanda, Self-Assembled Receptors for Protein Surface Recognition
Elsevier, Oxford, 351-369 2017

The Chemical Society of Japan

The Pharmaceutical Society of Japan

American Chemical Society

The Society of Synthetic Organic Chemistry, Japan

International Chemical Biology Society

Design of synthetic molecules that regulate protein interactions