Ph.D., Shinshu University

Animal production science

Applied microbiology

2025 - 2025
Shinshu University, Institute for Aqua Regeneration, Assistant Professor

2025 - Present
Shinshu University, Faculty of Agriculture Department of Agricultural and Life Sciences, Assistant Professor

2023 - Present
Tohoku University, Graduate School of Agricultural Science, Specially Appointed Assistant Professor

2021 - 2023
Shinshu University, Faculty of Agriculture, Postdoctoral Researcher

2021 - 2021
Nagasaki University, Nagasaki University NGS Center, Project Researcher

2019 - 2021
Research Fellowships of Japan Society for the Promotion of Science for Young Scientists (DC1)

2019 - 2021, Shinshu University, Graduate School of Medicine, Science and Technology, Department of Science and Technology

2017 - 2019, Shinshu University, Graduate School of Science and Technology, Department of Agriculture

2013 - 2017, Shinshu University, Faculty of Agriculture, Department of Food Production Science

2022
Japan Society for Lactic Acid Bacteria, Excellent Presentation Award

2019
日本畜産学会第126回大会（9月17日）, The Best Presentation Award for the 126th Annual Meeting of Japanese Society of Animal Science

2019
TASP2019（7月9日）, The Best Oral Presentation at The 2nd International Conference on Tropical Animal Science and Production 2019

2019
信州大学, 後援会長賞

2019
信州大学, Dean’s Award of Faculty of Agriculture of Shinshu University

2018
酪農科学シンポジウム2018（9月14日）, The Young Scientists Poster Award for the Dairy Science Symposium 2013

2018
Young Scientists Award/JSAS Excellent Presentation Award at The 18th Asian-Australasian Association of Animal Production Congress

A cross-sectional study of the gut microbiota associated with urinary and serum equol production status in a general population of Japanese men
Yukiko Okami; Hisatomi Arima; Shigeki Bamba; Fu Namai; Keiko Kondo; Yuki Ideno; Ayumi Soejima; Haruna Miyakawa; Sayuki Torii; Hiroyoshi Segawa; Mizuki Ohashi; Megumi Kawashima; Takashi Hisamatsu; Aya Kadota; Akira Sekikawa; Akira Fujiyoshi; Katsuyuki Miura
Food Bioscience, 71, 107048-107048, Sep. 2025, Refereed

The Originally Established PBE Cell Line as a Reliable In Vitro Model for Investigating SIV Infection and Immunity
Xi-Chen Bai; Kohtaro Fukuyama; Leonardo Albarracin; Yoshiya Imamura; Fu Namai; Weichen Gong; Wakako Ikeda-Ohtsubo; Keita Nishiyama; Julio Villena; Haruki Kitazawa
International Journal of Molecular Sciences, 26(12), 5764-5764, Jun. 2025, Refereed

Milk sialyl-oligosaccharides mediate the early colonization of gut commensal microbes in piglets.
Ryoga Hashimoto; Keita Nishiyama; Fu Namai; Kasumi Suzuki; Taiga Sakuma; Itsuko Fukuda; Yuta Sugiyama; Kenji Okano; Takafumi Shanoh; Eita Toyoshi; Ryusuke Ohgi; Sudeb Saha; Sae Tsuchida; Eri Nishiyama; Takao Mukai; Mutsumi Furukawa; Tomonori Nochi; Julio Villena; Wakako Ikeda-Ohtsubo; Gou Yoshioka; Eri Nakazaki; Yoshihito Suda; Haruki Kitazawa
Microbiome, 13(1), 135-135, May 2025

Modulation of Macrophages TLR4-Mediated Transcriptional Response by Lacticaseibacillus rhamnosus CRL1505 and Lactiplantibacillus plantarum CRL1506
Masahiko Suzuki; Ayelen Baillo; Leonardo Albarracin; Mariano Elean; Rodrigo Serda; Yoshihito Suda; Fu Namai; Keita Nishiyama; Haruki Kitazawa; Julio Villena
International Journal of Molecular Sciences, 26(6), 2688-2688, Mar. 2025, Refereed

Effect of Bacillus hisashii Supplementation on the Growth Performance, Nitrogen Excretion, and Intestinal Microbiota of Broiler Chickens Fed Low Crude Protein Diet
Motoi Kikusato; Fu Namai
Animal Science Journal, 96(1), Jan. 2025, Refereed, Not invited

Equol‐Producing Bacteria in the Chicken Intestine: PCR Analysis on the Bacteria Quantitatively Correlating With Equol Concentration in Daidzein‐Fed Laying Hens
Sota Sakai; Kyohei Furukawa; Fu Namai; Keita Nishiyama; Dipson Gyawali; Tatsuhiko Goto; Motoi Kikusato
Animal Science Journal, 96(1), e70068, Jan. 2025, Refereed

Effect of Feeding Sugarcane Bagasse-Extracted Polyphenolic Mixture on the Growth Performance, Meat Quality, and Oxidative and Inflammatory Status of Chronic Heat-Stressed Broiler Chickens
Motoi Kikusato; Fu Namai; Katsushige Yamada
Animals, 14(23), 3443-3443, Nov. 2024, Refereed

Oral administration of Limosilactobacillus ingluviei C37 inhibits Campylobacter jejuni colonization in chicks
Aito Murakami; Ayako Watanabe-Yanai; Taketoshi Iwata; Fu Namai; Takashi Sato; Tadashi Fujii; Takumi Tochio; Sutisa Khempaka; Takeshi Shimosato
Frontiers in Microbiology, 15(1491039), 1491039-1491039, Nov. 2024, Refereed

Modulation of the Gut–Lung Axis by Water Kefir and Kefiran and Their Impact on Toll-like Receptor 3-Mediated Respiratory Immunity
Stefania Dentice Maidana; Julio Nicolás Argañaraz Aybar; Leonardo Albarracin; Yoshiya Imamura; Luciano Arellano-Arriagada; Fu Namai; Yoshihito Suda; Keita Nishiyama; Julio Villena; Haruki Kitazawa
Biomolecules, 14(11), 1457-1457, Nov. 2024, Refereed

Koji amazake produced by double saccharification contains more isomaltose and modifies the gut microbiota in mice
Aito Murakami; Atsushi Saito; Fu Namai; Tadashi Fujii; Takumi Tochio; Jinichi Toida; Takeshi Shimosato
Frontiers in Nutrition, 11, 1489912-1489912, Nov. 2024, Refereed

Development of engineered IL-36γ-hypersecreting Lactococcus lactis to improve the intestinal environment
Masahiro Yoda; Shogo Takase; Kaho Suzuki; Aito Murakami; Fu Namai; Takashi Sato; Tadashi Fujii; Takumi Tochio; Takeshi Shimosato
World Journal of Microbiology and Biotechnology, 40(11), 363-363, Oct. 2024, Refereed

Exploring strain-level diversity in the gut microbiome through mucin particle adhesion
Keita Nishiyama; Ryuta Murakami; Masaki Nakahata; Binghui Zhou; Nanami Hashikura; Hiroki Kaneko; Fu Namai; Wakako Ikeda-Ohtsubo; Jin-Zhong Xiao; Haruki Kitazawa; Toshitaka Odamaki
Applied and Environmental Microbiology, 90(9), e0123524, Sep. 2024, Refereed

Role of immunomodulatory probiotics in alleviating bacterial diarrhea in piglets: a systematic review
Sudeb Saha; Fu Namai; Keita Nishiyama; Julio Villena; Haruki Kitazawa
Journal of Animal Science and Biotechnology, 15(1), 112-112, Aug. 2024, Refereed

Modulation of the Toll-like Receptor 3-Mediated Intestinal Immune Response by Water Kefir
Stefania Dentice Maidana; Ramiro Ortiz Moyano; Mariano Elean; Yoshiya Imamura; Leonardo Albarracín; Fu Namai; Yoshihito Suda; Keita Nishiyama; Julio Villena; Haruki Kitazawa
Microbiology Research, 15(3), 1239-1250, Jul. 2024, Refereed

Antagonistic Effects of Corynebacterium pseudodiphtheriticum 090104 on Respiratory Pathogens
Ramiro Ortiz Moyano; Stefania Dentice Maidana; Yoshiya Imamura; Mariano Elean; Fu Namai; Yoshihito Suda; Keita Nishiyama; Vyacheslav Melnikov; Haruki Kitazawa; Julio Villena
Microorganisms, 12(7), 1295-1295, Jun. 2024, Refereed

The Mucus-Binding Factor Mediates Lacticaseibacillus rhamnosus CRL1505 Adhesion but Not Immunomodulation in the Respiratory Tract
Binghui Zhou; Mariano Elean; Lorena Arce; Kohtaro Fukuyama; Kae Tomotsune; Stefania Dentice Maidana; Sudeb Saha; Fu Namai; Keita Nishiyama; María Guadalupe Vizoso-Pinto; Julio Villena; Haruki Kitazawa
Microorganisms, 12(6), 1209-1209, Jun. 2024, Refereed

Ad libitum feeding of silkworm larvae powder-containing diets specifically influences metabolism-related and short-chain fatty acid-producing gut bacteria in mice
Aito Murakami; Haruka Yamaguchi; Fu Namai; Takashi Sato; Maki Yamazaki; Hiroshi Uehara; Tadashi Fujii; Takumi Tochio; Kunihiro Shiomi; Takeshi Shimosato
Frontiers in Cellular and Infection Microbiology, 14, 1383774-1383774, Jun. 2024, Refereed

Insights into the Anti-Adipogenic and Anti-Inflammatory Potentialities of Probiotics against Obesity
A. K. M. Humayun Kober; Sudeb Saha; Mutamed Ayyash; Fu Namai; Keita Nishiyama; Kazutoyo Yoda; Julio Villena; Haruki Kitazawa
Nutrients, 16(9), 1373-1373, Apr. 2024, Refereed

In vitro evaluation of the immunomodulatory and wakame assimilation properties of Lactiplantibacillus plantarum strains from swine milk
Ryusuke Ohgi; Sudeb Saha; Binghui Zhou; Taiga Sakuma; Mitsuki Sakurai; Yuhka Nakano; Fu Namai; Wakako Ikeda-Ohtsubo; Yoshihito Suda; Keita Nishiyama; Julio Villena; Haruki Kitazawa
Frontiers in Microbiology, 15, 1324999-1324999, Jan. 2024, Refereed

Development of an intestinal epithelial cell line and organoids derived from the same swine and characterization of their antiviral responses
Kaho MATSUMOTO; Fu NAMAI; Ayako MIYAZAKI; Yoshiya IMAMURA; Kohtaro FUKUYAMA; Wakako IKEDA-OHTSUBO; Keita NISHIYAMA; Julio VILLENA; Kohtaro MIYAZAWA; Haruki KITAZAWA
Bioscience of Microbiota, Food and Health, 43(4), 342-351, 2024, Refereed
Lead

Lacticaseibacillus rhamnosus CRL1505 Peptidoglycan Modulates the Inflammation-Coagulation Response Triggered by Poly(I:C) in the Respiratory Tract
Hortensia Zelaya; Luciano Arellano-Arriagada; Kohtaro Fukuyama; Kaho Matsumoto; Gabriela Marranzino; Fu Namai; Susana Salva; Susana Alvarez; Graciela Agüero; Haruki Kitazawa; Julio Villena
International Journal of Molecular Sciences, 24(23), 16907-16907, Nov. 2023, Refereed

Establishment of porcine fecal-derived ex vivo microbial communities to evaluate the impact of livestock feed on gut microbiome
Yuji TSUJIKAWA; Keita NISHIYAMA; Fu NAMAI; Yoshiya IMAMURA; Taiga SAKUMA; Sudeb SAHA; Masahiko SUZUKI; Mitsuki SAKURAI; Ryo IWATA; Kengo MATSUO; Hironori TAKAMORI; Yoshihito SUDA; Binghui ZHOU; Itsuko FUKUDA; Julio VILLENA; Iwao SAKANE; Ro OSAWA; Haruki KITAZAWA
Bioscience of Microbiota, Food and Health, 43(2), 100-109, Nov. 2023, Refereed
Lead

Immunobiotic Ligilactobacillus salivarius FFIG58 Confers Long-Term Protection against Streptococcus pneumoniae
Mariano Elean; Fernanda Raya-Tonetti; Kohtaro Fukuyama; Luciano Arellano-Arriagada; Fu Namai; Yoshihito Suda; Nadia Gobbato; Keita Nishiyama; Julio Villena; Haruki Kitazawa
International Journal of Molecular Sciences, 24(21):15773, 1-16, Oct. 2023, Refereed, Not invited

Recent Advances in the Use of Probiotics to Improve Meat Quality of Small Ruminants: A Review
Sudeb Saha; Kohtaro Fukuyama; Marina Debnath; Fu Namai; Keita Nishiyama; Haruki Kitazawa
Microorganisms, 11(7), 1652-1652, Jun. 2023, Refereed

Partial Characterization and Immunomodulatory Effects of Exopolysaccharides from Streptococcus thermophilus SBC8781 during Soy Milk and Cow Milk Fermentation
Hajime Nakata; Yoshiya Imamura; Sudeb Saha; René Emanuel Lobo; Shugo Kitahara; Shota Araki; Mikado Tomokiyo; Fu Namai; Masanori Hiramitsu; Takashi Inoue; Keita Nishiyama; Julio Villena; Haruki Kitazawa
Foods, 12(12), 2374-2374, Jun. 2023, Refereed

Development of a Single-Chain Fragment Variable that Binds to the SARS-CoV-2 Spike Protein Produced by Genetically Modified Lactic Acid Bacteria
Suzuka Oshima; Fu Namai; Takashi Sato; Takeshi Shimosato
Molecular Biotechnology, 66(1), 151-160, Apr. 2023, Refereed
Lead

Development of fluorescence-labeled antibody for immune checkpoint inhibitor using engineered probiotics
Fu Namai; Shunsuke Sumiya; Natsumi Nomura; Takashi Sato; Takeshi Shimosato
AMB Express, 13(1), Jan. 2023, Refereed
Lead

Oral administration of Brevibacterium linens from washed cheese increases the proportions of short‐chain fatty acid‐producing bacteria and lactobacilli in the gut microbiota of mice
Aito Murakami; Koharu Toyomoto; Fu Namai; Takashi Sato; Tadashi Fujii; Takumi Tochio; Takeshi Shimosato
Animal Science Journal, 94(1), e13905, Jan. 2023, Refereed

Developmental research on lactic acid bacteria with preferred properties
Fu Namai; Takeshi Sshimosato
Japan Society for Lactic Acid Bacteria, 33(1), 5-11, Mar. 2022, Refereed, Invited
Lead

Free Feeding of CpG-Oligodeoxynucleotide Particles Prophylactically Attenuates Allergic Airway Inflammation and Hyperresponsiveness in Mice
Takuma Okajima; Suguru Shigemori; Fu Namai; Tasuku Ogita; Takashi Sato; Takeshi Shimosato
Front Immunol., 12:738041., Nov. 2021, Refereed

A Soybean Resistant Protein-Containing Diet Increased the Production of Reg3γ Through the Regulation of the Gut Microbiota and Enhanced the Intestinal Barrier Function in Mice
Tasuku Ogita; Fu Namai; Ayane Mikami; Takahiro Ishiguro; Koji Umezawa; Yutaka Uyeno; Takeshi Shimosato
Front Nutr., 8:701466., Aug. 2021, Refereed
Lead

Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17
Ayane Mikami; Tasuku Ogita; Fu Namai; Suguru Shigemori; Takashi Sato; Takeshi Shimosato
Front Nutr., 7:610946., Feb. 2021, Refereed, Not invited

Nasally Administered Lactococcus lactis Secreting Heme Oxygenase-1 Attenuates Murine Emphysema
Kentaro Yumoto; Takashi Sato; Kentaro Nakashima; Fu Namai; Suguru Shigemori; Takeshi Shimosato; Takeshi Kaneko
Antioxidants, 9(11), 1049-1049, Oct. 2020, Refereed, Not invited

Oral priming with oligodeoxynucleotide particles from Lactobacillus rhamnosus GG attenuates symptoms of dextran sodium sulfate‐induced acute colitis in mice
Suguru Shigemori; Fu Namai; Tasuku Ogita; Takashi Sato; Takeshi Shimosato
Anim Sci J ., 91(1), Oct. 2020, Refereed, Not invited

Ribosome-Engineered Lacticaseibacillus rhamnosus Strain GG Exhibits Cell Surface Glyceraldehyde-3-Phosphate Dehydrogenase Accumulation and Enhanced Adhesion to Human Colonic Mucin
Minori Ishida; Fu Namai; Suguru Shigemori; Shoko Kajikawa; Masami Tsukagoshi; Takashi Sato; Tasuku Ogita; Takeshi Shimosato
Applied and Environmental Microbiology, 86(20), Oct. 2020, Refereed
Lead

Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice
Fu Namai; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Takeshi Shimosato
Exp Mol Med., 52(9), 1627-1636, Sep. 2020, Refereed, Not invited
Lead

Construction of Genetically Modified Lactococcus lactis Producing Anti-human-CTLA-4 Single-Chain Fragment Variable
Fu Namai; Aito Murakami; Asami Ueda; Masami Tsukagoshi; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Takeshi Shimosato
Mol Biotechnol., 62(11-12), 572-579, Sep. 2020, Refereed, Not invited
Lead

Construction of genetically modified Lactococcus lactis that produces bioactive anti-interleukin-4 single-chain fragment variable
Fu Namai; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Takeshi Shimosato
Mol Biol Rep., 47(9), 7039-7047, Sep. 2020, Refereed, Not invited
Lead

Oral administration of Flavonifractor plautii attenuates inflammatory responses in obese adipose tissue
Ayane Mikami; Tasuku Ogita; Fu Namai; Suguru Shigemori; Takashi Sato; Takeshi Shimosato
Mol Biol Rep., 47(9), 6717-6725, Aug. 2020, Refereed, Not invited

Lactobacillus ingluviei C37 from chicken inhibits inflammation in LPS‐stimulated mouse macrophages
Masami Tsukagoshi; Merisa Sirisopapong; Fu Namai; Minori Ishida; Supattra Okrathok; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Sutisa Khempaka; Takeshi Shimosato
Animal Science Journal, 91(1):e13436., Jan. 2020, Refereed

Recombinant mouse calcitonin gene-related peptide secreted by Lactococcus lactis inhibits lipopolysaccharide-induced inflammatory response in macrophages.
Fu Namai; Yoshinari Yamamoto; Takashi Sato; Tasuku Ogita; Takeshi Shimosato
Anim Sci J., 89(12), 1707-1711, Dec. 2018, Refereed, Not invited
Lead

Recombinant Mouse Osteocalcin Secreted by Lactococcus lactis Promotes Glucagon-Like Peptide-1 Induction in STC-1 Cells.
Fu Namai; Suguru Shigemori; Koichi Sudo; Takashi Sato; Yoshinari Yamamoto; Shireen Nigar; Tasuku Ogita; Takeshi Shimosato
Curr Microbiol., 75(1), 92-98, Jan. 2018, Refereed, Not invited
Lead

Genetically modified Lactococcus lactis producing a green fluorescent protein–bovine lactoferrin fusion protein suppresses proinflammatory cytokine expression in lipopolysaccharide-stimulated RAW 264.7 cells
Suguru Shigemori; Fu Namai; Yoshinari Yamamoto; Shireen Nigar; Takashi. Sato; Tasuku Ogita; Takeshi Shimosato
Journal of Dairy Science, 100(9), 7007-7015, Sep. 2017

Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock via Activation of Platelet-Activating Factor Acetylhydrolase
Yoshinari Yamamoto; Ryu Sugimura; Takafumi Watanabe; Suguru Shigemori; Takuma Okajima; Shireen Nigar; Fu Namai; Takashi Sato; Tasuku Ogita; Takeshi Shimosato
Frontiers in Immunology, 8:1049., Aug. 2017, Refereed

Intratracheal therapy using nintedanib amorphous particles in murine pulmonary fibrosis
Kaho Suzuki; Fu Namai; Aito Murakami; Yuichi Sato; Akihiro Kotsugai; Takeshi Shimosato; Takashi Sato
European Respiratory Journal, 64(suppl 68), OA4557 - OA4557, 14 Sep. 2024
https://syndication.highwire.org/content/doi/10.1183/13993003.congress-2024.OA4557

腸-肺軸を介する「ポストイムノバイオティクス」の抗ウイルス免疫機能評価
福山皓太朗; 福山皓太朗; 生井楓; 生井楓; 大坪和香子; 大坪和香子; 西山啓太; 西山啓太; VILLENA Julio; VILLENA Julio; 北澤春樹; 北澤春樹
日本畜産学会大会講演要旨, 132nd, 2024

乳酸菌によるシアロオリゴ糖代謝から見た子豚の腸内細菌叢形成
橋本凌河; 西山啓太; 生井楓; 鈴木香澄; 鈴木香澄; 福田伊津子; 杉山友太; 大坪和香子; 吉岡豪; 中崎瑛里; 北澤春樹
ミルクサイエンス(Web), 73(2), 2024

Development of piglet gut microbiota through sialo-oligosaccharide metabolism by lactic acid bacteria.
橋本凌河; 西山啓太; 生井楓; 鈴木香澄; 鈴木香澄; 福田伊津子; 杉山友太; 豊吉瑛太; 佐久間大河; 大坪和香子; 吉岡豪; 中崎瑛里; 北澤春樹
日本乳酸菌学会誌, 35(2), 2024

Intranasal Administration of Genetically Modified Lactococcus Lactis Producing PD-L1 scFv Improves Survival in Lung Cancer Model Mice
N. Nomura; F. Namai; T. Sato; T. Shimosato
C70. COPD (AND LUNG CANCER) CLINICAL AND TRANSLATIONAL STUDIES, A5754 - A5754, 01 May 2023

腸内細菌は閉塞性黄疸により影響されるのか
増尾仁志; 生井楓; 副島雄二
胆と膵, 44(3), 223 - 227, Mar. 2023, Invited

ブタ腸管上皮細胞においてミトコンドリア機能を改善するポストイムノバイオティクスの探索
生井楓; 生井楓; 鈴木眞依; 笠原日菜子; 西山啓太; 西山啓太; 大坪和香子; 大坪和香子; 北澤春樹; 北澤春樹
日本畜産学会大会講演要旨, 131st, 2023

乳腺上皮細胞における乳成分の炎症制御に関する基礎的研究
福山皓太朗; 生井楓; 生井楓; 周冰卉; 周冰卉; 大坪和香子; 大坪和香子; 西山啓太; 西山啓太; 麻生久; 麻生久; 北澤春樹; 北澤春樹
ミルクサイエンス(Web), 72(2), 2023

Lactic Acid Bacteria Methods and Protocols
Fu Namai; Keita Nishiyama; Haruki Kitazawa; Takeshi Shimosato, Contributor, Introduction of Spontaneous Mutations Using Streptomycin as a Method for Lactic Acid Bacteria Breeding
Humana New York, Aug. 2024
ISBN:9781071640951

ワカメ未利用部位とワカメ資化性イムノバイオティクス乳酸菌の離乳子豚への給与によ るイムノシンバイオティクス効果の検証
宗田 吉広; 生井 楓; 須田 義人; 今井 勇志; 小林 朋生; 曽地 雄一郎; 西山 啓太; 上本 吉伸; 新開 浩樹; 北澤 春樹
日本乳酸菌学会2025年度大会, Jul. 2025, Not invited

ポストイムノバイオティクスの抗ウイルス機能を司る責任因子と宿主受容体の解明
今村 圭哉; Leonardo Albarraci; 盛一 伸子; 生井 楓; 大坪 和香子; 宮﨑 綾子; 西山 啓太; 北澤 春樹
日本乳酸菌学会2025年度大会, Jul. 2025, Not invited

乳酸菌桿菌の腸管マクロファージにおけるミトコンドリア調節機能
針生 希; 生井 楓; 大坪 和香子; 西山 啓太; 北澤 春樹
日本乳酸菌学会2025年度大会, Jul. 2025, Not invited,

抗 IL-31Ra 低分子抗体を産生する Lactococcus lactis 組換え体の構築と機能評価
村上 愛斗; 生井 楓; 下里 剛士
日本乳酸菌学会2025年度大会, Jul. 2025, Not invited

子宮切断術摘出・初乳未接種豚への糞便細菌叢移植実験系の構築
須田 遊人; 生井 楓; 宗田 吉広; 西川 明芳; 大橋 誠一; 岸田 なつみ; 橘 紅李; 今村 圭哉; 松本 夏; 福山 皓太; 西山 啓太; 北澤 春樹; 宮﨑 綾子
日本畜産学会第132回大会, Sep. 2024

Establishment of a mitochondrial function evaluation system in porcine intestinal macrophages
針生 希; 生井 楓; 竹之内 敬; 大坪 和香; 西山 啓太; 上西 博英; 北澤 春樹
日本畜産学会第132回大会, Sep. 2024

抗インターロイキン6Rα低分子抗体を産生する乳酸菌組換え体の抗炎症作用
依田将宏; 村上愛斗; 生井楓; 下里剛士
日本畜産学会第132回大会, Sep. 2024, Not invited

腸-肺軸を介する「ポストイムノバイオティクス」の抗ウイルス免疫機能評価
福山 皓太; 生井 楓; 大坪 和香; 西山 啓太; Julio Villena; 北澤 春樹
日本畜産学会第132回大会, Sep. 2024

Production of bioactive compounds through Food by-product metabolism by pig gut microbiota
豊吉 瑛太; 生井 楓; 渡邊 真広; 吉田 安佑; 石原 沙耶花; 小田巻 俊; 大坪 和香; 前川 正充; 西山 啓太; 北澤 春樹
日本畜産学会第132回大会, Sep. 2024

ニワトリにおけるエクオール産生菌の探索
坂井 創太; 生井 楓; 古川 恭平; 西山 啓太; 喜久里 基
日本畜産学会第132回大会, Sep. 2024

子宮切断術摘出・初乳未接種豚への糞便細菌叢移植とその腸管のバリア機能と免疫学的影響の解析
須田遊人; 生井 楓; 宗田吉広; 西川明芳; 大橋誠一; 岸田なつみ; 橘 紅李; 西山啓太; 北澤春樹; 宮崎綾子
第167回日本獣医学会学術集会, Sep. 2024

乳酸菌によるシアロオリゴ糖代謝から見た子豚の腸内細菌叢形成
橋本凌河; 西山啓太; 生井楓; 鈴木香澄; 福田伊津子; 杉山友太; 大坪和香子; 岡豪; 中﨑瑛里; 北澤春樹
酪農科学シンポジウム2024, Sep. 2024

乳酸菌によるシアロオリゴ糖代謝に着目した 子豚の腸内細菌叢形成とその意義
橋本凌河; 西山啓太; 井楓; 鈴木香澄; 福田伊津子; 杉山友太; 豊吉瑛太; 佐久間大河; 大坪和香子; ��岡豪; 中﨑瑛里; 北澤春樹
日本乳酸菌学会2024年度大会, Jul. 2024

Effects of sialylated milk oligosaccharides on gut microbiome development in piglets
Keita Nishiyama; Ryoga Hashimoto; Fu Namai; Haruki Kitazawa
ACLAB14, May 2024

Postimmunobiotics prevent mitochondrial dysfunction in porcine intestinal epithelial cells
Fu Namai; Mai Suzuki; Keita Nishiyama; Haruki Kitazawa
ACLAB14, May 2024

Porcine small intestinal organoids to evaluate postimmunobiotics with anti-rotavirus activity
Kaho Matsumoto; Fu Namai; Yoshiya Imamura; Shota Araki; Keita Nishiyama; Haruki Kitazawa
ACLAB14, May 2024

Intranasally administrable microbial therapeutics for lung cancer based on immune-checkpoint inhibitory scFv-producing genetically modified lactic acid bacteria
Fu Namai
International workshop 2023 Inhaled Probiotic Therapy Next Era Therapeutic Modality for Lung Cancer, Dec. 2023, Invited

乳酸菌による母乳オリゴ糖代謝から紐解く仔豚のマイクロバイオーム形成
橋本凌河; 生井楓; 佐久間大河; 鈴木香澄; 中﨑瑛里; 西山啓太; 北澤春樹
2023年度日本乳酸菌学会泊まり込みセミナー, Nov. 2023

ブタ小腸オルガノイドを用いたポストイムノバイオティクスの評価系構築
松本夏歩; 西山啓太; 宮﨑綾子; 北澤春樹
2023年度日本乳酸菌学会泊まり込みセミナー, Nov. 2023

肥満モデルマウスにおけるIL-1受容体アンタゴニストを高産生する乳酸菌組換え体の作用効果
野村奈津実; 生井楓; 下里剛士
日本畜産学会第131回大会, Sep. 2023

抗インターロイキン6Rα低分子抗体を産生する乳酸菌組換え体の構築
依田将宏; 生井楓; 下里剛士
日本畜産学会第131回大会, Sep. 2023, Not invited

ブタ腸管上皮細胞においてミトコンドリア機能を改善するポストイムノバイオティクスの探索
生井 楓; 鈴木 眞依; 笠原 日菜子; 西山 啓太; 大坪 和香; 北澤 春樹
日本畜産学会第131回大会, Sep. 2023

Establishment of an antiviral immunobiotic evaluation system in porcine intestinal epithelial cells and macrophages
柴田 諒子; 今村 圭哉; 荒木 祥多; Sudeb Sah; 生井 楓; 宮崎 綾子; 宮澤 光太郎; 大坪 和香; 西山 啓太; 北澤 春樹
日本畜産学会第131回大会, Sep. 2023

Isolation of immunobiotic candidates from maternal microbiota focusing on endogenous antibiotic factors
佐久間 大河; 扇 隆介; 櫻井 美月; 中野 祐香; Saha Sude; 生井 楓; 大坪 和香; 須田 義人; 西山 啓太; 北澤 春樹
日本畜産学会第131回大会, Sep. 2023

Effect of orally administered Ligilactobacillus salivarius and its CbpA mutant on TLR3-mediated intestinal immunity
Sudeb Saha; Hikari Yamamuro; Yoshiya Imamura; Mariano Elean; Leonardo Albarracin; Binghui Zhou; Fu Namai; Wakako Ikeda-Ohtsubo; Keita Nishiyama; Julio Villena; Haruki Kitazawa
日本畜産学会第131回大会, Sep. 2023

新規抗ウイルス性「ポストイムノバイオティクス」の選抜・機構解明（優秀発表賞 受賞）
今村 圭哉; 荒木 祥多; 生井 楓; 宮﨑 綾子; 須田 遊人; 大坪 和香; 西山 啓太; 北澤 春樹
日本畜産学会第131回大会, Sep. 2023

プロバイオティック乳酸菌の機能強化と菌体表層タンパク質および細胞外小胞がもたらす異なる免疫応答（優秀発表賞 受賞）
Jamiyanpurev Soyolmaa; 生井楓; 木下英樹; 下里剛士
日本畜産学会第131回大会, Sep. 2023

Expression of GFP-CC12.1 scFv Fusion Protein in Lactococcus lactis
大島涼香; 生井楓; 重盛駿; 下里剛士
日本畜産学会第130回大会, Sep. 2023

Construction of Genetically Modified Lactic Acid Bacteria Secreting Recombinant Anti-CTLA-4 scFv
野村奈津実; 生井楓; 重盛駿; 下里剛士
日本畜産学会第130回大会, Sep. 2023

Recombinant mouse interleukin 36 γ secreted by Lactococcus lactis induces Muc2 mRNA expression in mouse colon cells
髙瀨渉吾; 生井楓; 重盛駿; 下里剛士
日本畜産学会第130回大会, Sep. 2023

免疫チェックポイント阻害乳酸菌の経鼻投与による原発性肺ガンの抑制効果（若手優秀ポスター賞 受賞）
野村奈津実; 生井楓; 村上愛斗; 佐藤隆; 下里剛士
酪農科学シンポジウム2023, Sep. 2023

Microbial therapeutics for lung cancer based on immune-checkpoint inhibitory scFv-producing engineered lactic acid bacteria
Fu Namai; Haruki Kitazawa; Takashi Sato; Takeshi Shimosato
FEMS 2023, Jul. 2023, Not invited

The rpsL K56N mutation in Lacticaseibacillus rhamnosus GG enhances immune response via cell surface proteins
Soyolmaa Jamiyanpurev; Fu Namai; Takashi Sato; Takeshi Shimosato
ISAPP 2023 annual meeting, Jun. 2023

Effect of Local Intratracheal Therapy Using Particleized Nintedanib in a Murine Model of Pulmonary Fibrosis
K. Suzuki; F. Namai; N. Nomura; Y. Sato; A. Kotsugai; T. Shimosato; T. Sato
ATS 2023 International Conference, May 2023, Not invited

Intranasal Administration of Genetically Modified Lactococcus Lactis Producing PD-L1 scFv Improves Survival in Lung Cancer Model Mice
N. Nomura; F. Namai; T. Sato; T. Shimosato
ATS 2023 International Conference, May 2023, Not invited

Functional enhancement and evaluation of ribosome-engineeredLimosilactobacillus ingluviei C37 from broiler chicken
Jamiyanpurev Soyolmaa; 生井楓; 重盛駿; 下里剛士
日本畜産学会第130回大会, Sep. 2022

GFP融合抗PD-L1低分子抗体を産生する Lactococcus lactis組換え体の構築（若手優秀ポスター賞 受賞）
角谷駿介; 生井楓; 重盛駿; 下里剛士
酪農科学シンポジウム2022, Sep. 2022

Lacticaseibacillus rhamnosus GGにおけるrpsL変異がもたらす菌体表層タンパク質の免疫賦活効果
生井楓; 下里剛士
2022年度乳酸菌学会大会, Jul. 2022, Not invited

Bacterial changes associated with the rpsL gene mutation in Lacticaseibacillus rhamnosus GG
Masami Tsukagoshi; Fu Namai; Suguru Shigemori; Takeshi Shimosato
The 11th Asian Conference for Lactic Acid Bacteria, Nov. 2021

腸内常在性乳酸菌における イムノバイオティック機能の強化
金山理佐; 生井楓; 重盛駿; 下里剛士
酪農科学シンポジウム2021, Sep. 2021

乳酸菌組換え体の経口投与によるIL-1Ra腸管送達能の検証
生井楓; 重盛駿; 荻田佑; 下里剛士
日本畜産学会第129回大会, Sep. 2021, Not invited

ウォッシュタイプチーズにおける 機能性成分の解析と免疫調節作用
樋本小春; 生井楓; 重盛駿; 荻田佑; 下里剛士
日本畜産学会第129回大会, Sep. 2021

Construction of genetically modified lactic acid bacteria producing anti-IL31Ra single-chain Fragment variable (English Presentation Award)
Aito Murakami; Fu Namai; Suguru Shigemori; Ogita Tasuku; Takeshi Shimosato
The 129th Annual Meeting of Japanese Society of Animal Science, Sep. 2021

Lactobacillus ingluviei C37 from broiler inhibits inflammation in LPS-stimulated mouse macrophages (English Presentation Award)
Masami Tsukagoshi; Fu Namai; Suguru Shigemori; Ogita Tasuku; Takeshi Shimosato
The 129th Annual Meeting of Japanese Society of Animal Science, Sep. 2021, Not invited

抗PD-L1scFvを分泌する乳酸菌組換え体の構築
村上愛斗; 生井楓; 重盛駿; 荻田佑; 下里剛士
日本畜産学会第128回大会, Mar. 2021, Not invited

乳酸菌組換え体が産生する抗インターロイキン4低分子抗体の生理活性評価
Fu Namai; Suguru Shigemori; Tasuku Ogita; Takeshi Shimosato
The 128th Annual Meeting of Japanese Society of Animal Science, Mar. 2021

A breeding strategy of ribosome engineering for probiotics enhances the adhesion to human colonic mucin in Lacticaseibacillus rhamnosus GG
Fu Namai; Suguru Shigemori; Takeshi Shimosato
LSBBA 2021 Annual Meeting, Mar. 2021, Not invited

IL-1RA分泌乳酸菌組換え体の大腸炎における炎症改善効果と盲腸内細菌叢への影響
生井楓; 重盛駿; 荻田佑; 下里剛士
日本畜産学会第126回大会, Sep. 2019, Not invited

PD-1/PD-L1チェックポイントの阻害に働く乳酸菌組換え体の構築と肺ガンモデルマウスを用いた検証
上田麻未; 生井楓; 村上愛斗; 重盛駿; 荻田佑; 佐藤隆; 下里剛士
酪農科学シンポジウム2019, Aug. 2019, Not invited

抗CTLA-4低分子抗体を産生するLactococcus lactis組換え体の構築
村上愛斗; 生井楓; 上田麻未; 重盛駿; 荻田佑; 佐藤隆; 下里剛士
酪農科学シンポジウム2019, Aug. 2019, Not invited

Lactobacillus rhamnosus GGに対する薬剤耐性選抜法の応用と分泌型タンパク質の産生能に与える影響
石田みのり; 梶川祥子; 生井楓; 荻田佑; 重盛駿; 下里剛士
酪農科学シンポジウム2019, Aug. 2019, Not invited

Lactococcus lactis組換え体の産生する抗インターロイキン4低分子抗体の免疫調節作用
渡邉 康平; 生井楓; 荻田佑; 重盛駿; 下里剛士
酪農科学シンポジウム2019, Aug. 2019, Not invited

Genetically modified Lactococcus lactis secreting recombinant osteocalcin improves glucose tolerance in diet-induced obesity
Fu Namai; Suguru Shigemori; Tasuku Ogita; Takeshi Shimosato
The 2nd International Conference on Tropical Animal Science and Production 2019, Jul. 2019, Not invited

Ribosome engineering enhances production of p40, a Lactobacillus rhamnosus GG-derived soluble protein, in S12 mutant strains
Shoko Kajikawa; Minori Ishida; Fu Namai; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Takeshi Shimosato
13th International Scientific Conference on Probiotics, Prebiotics, Gut Mirobiota and Health, Jun. 2019, Not invited

Construction of a genetically modified Lactococcus lactis producing single chain Fv against vascular endothelial growth factor
Masami Tsukagoshi; Fu Namai; Kohei Watanabe; Minako Iwai; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Takeshi Shimosato
13th International Scientific Conference on Probiotics, Prebiotics, Gut Mirobiota and Health, Jun. 2019, Not invited

Oral Administration of a Genetically Modified Osteocalcin-Secreting Lactococcus lactic Improves Carbohydrate Metabolism in High-Fat Diet-Induced Obese Mice
Fu Namai; Suguru Shigemori; Tasuku Ogita; Takeshi Shimosato
13th International Scientific Conference on Probiotics, Prebiotics, Gut Mirobiota and Health, Jun. 2019, Not invited

Lactobacillus rhamnosus GG変異株におけるp40タンパク質産生能の強化
梶川祥子; 石田みのり; 生井楓; 重盛駿; 荻田佑; 下里剛士
日本畜産学会第125回大会, Mar. 2019, Not invited

抗PD-1 scFvを産生する乳酸菌組換え体の構築
上田麻未; 生井楓; 重盛駿; 荻田佑; 下里剛士
日本畜産学会第125回大会, Mar. 2019, Not invited

乳酸菌組換え体が分泌するカルシトニン遺伝子関連ペプチドのマウスマクロファージにおける抗炎症効果
生井楓; 重盛駿; 荻田佑; 下里剛士
日本畜産学会第125回大会, Mar. 2019, Not invited

オステオカルシンを分泌するLactococcus lactis組換え体の 経口投与による糖代謝促進効果
生井楓; 荻田佑; 下里剛士
酪農科学シンポジウム2018, Sep. 2018, Not invited

Advanced Application of Ribosome Engineering in Lactobacillus rhamnosus GG
Minori Ishida; Fu Namai; Tasuku Ogita; Takeshi Shimosato
The 18th Asian-Australasian Animal Production Congress, Aug. 2018, Not invited

Recombinant mouse calcitonin gene-related peptidesecreted by Lactococcus lactis inhibits lipopolysaccharide-induced inflammatory response in macrophages
Fu Namai; Tasku Ogita; Takeshi Shimosato
The 18th Asian-Australasian Animal Production Congress, Aug. 2018, Not invited

Lactobacillus rhamnosus GGにおける薬剤耐性変異の導入
石田みのり; 重盛駿; 生井楓; 荻田佑; 下里剛士
日本畜産学会第124回大会, Mar. 2018, Not invited

オステオカルシンを分泌する乳酸菌組換え体は肥満モデルマウスにおける耐糖能を改善する
生井楓; 重盛駿; 荻田佑; 下里剛士
日本畜産学会第124回大会, Mar. 2018, Not invited

Construction of genetically modified Lactococcus lactis secreting bioactive osteocalcin
Fu Namai; Suguru Shigemori; Tasuku Ogita; Takeshi Shimosato
IDF World Dairy Summit 2017, Oct. 2017, Not invited

IL-1RAを分泌する乳酸菌組換え体の経口投与による大腸炎軽減効果
生井楓; 重盛駿; 荻田佑; 下里剛士
日本畜産学会第123回大会, Sep. 2017, Not invited

オステオカルシンを分泌するLactococcus lactis組換え体の インスリン分泌促進効果
生井楓; 重盛駿; 荻田佑; 下里剛士
酪農科学シンポジウム2017, Aug. 2017, Not invited

乳酸菌組換え体が分泌するオステオカルシンの生理活性の検証
生井楓; 重盛駿; 荻田佑; 下里剛士
日本畜産学会第122回大会, Mar. 2017, Not invited

オステオカルシンを分泌するLactococcus lactis組換え体の構築
生井楓; 重盛駿; 下里剛士
酪農科学シンポジウム2016, Sep. 2016, Not invited

Mar. 2017 - Present
Japanese Society of Animal Science

腸内乳酸菌によるポリアミン産生を介したロタウイルス不顕性感染の誘導・機序解明
科学研究費助成事業, 日本学術振興会, 若手研究
東北大学
01 Apr. 2025 - 31 Mar. 2027

子ブタ腸内に優勢となる乳酸菌による母乳成分の代謝がもたらす腸管恒常性維持機構
科学研究費助成事業, 日本学術振興会, 研究活動スタート支援
東北大学
Aug. 2023 - Mar. 2025

腸内細菌を有効活用した家畜健全育成に貢献する機能性エコフィードの開発基盤創成
科学研究費助成事業, 日本学術振興会, 基盤研究(B)
東北大学
Apr. 2023 - Mar. 2026

Innovative therapy for lung cancer: prophylaxis and therapy by intratracheal delivery of probiotics harboring immune checkpoint-blocking single-chain variable fragment
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
Shinshu University
Oct. 2019 - Mar. 2024

腸内常在性乳酸菌の生体外機能強化系の確立と宿主への還元性評価
科学研究費助成事業 特別研究員奨励費, 日本学術振興会, 特別研究員奨励費
信州大学
25 Apr. 2019 - 31 Mar. 2022