Doctor of Medicine, Kyoto University

Laboratory animal science

病態遺伝学（老化病態の分子生物学）

1993, Kyoto UniversityGraduate School of Medicine, 医学研究科

1988, Kyoto University Graduate School of Agriculture, 農学研究科

1986, Kyoto University, Faculty of Agriculture

2024
公益社団法人 日本実験動物学会, 2023年 Experimental Animals 最優秀論文賞

2023
老化促進モデルマウス（SAM）学会, 功労賞

2007
社団法人 日本実験動物学会, 2007年 Experimental Animals 最優秀論文賞
Japan
Experimental Ami,als 最優秀論文賞

2007
日本実験動物学会, Experimental Animals 最優秀論文賞
Official journal

2007
日本疾患モデル学会, 第24回 日本疾患モデル学会 優秀発表賞
Japan
第２4回 日本疾患モデル学会 優秀発表賞

2004
日本疾患モデル学会, 第21回 日本疾患モデル学会 最優秀発表賞
Japan
第２１回 日本疾患モデル学会 最優秀発表賞

2000
日本実験動物学会, 日本実験動物学会奨励賞
Japan
日本実験動物学会奨励賞

BALB.NCT-Cpox is a unique mouse model of hereditary coproporphyria
Xiaojing Kang; Shin Shimada; Hiroki Miyahara; Keiichi Higuchi; Masayuki Mori
Molecular Genetics and Metabolism Reports, 35, 100964-100964, Jun. 2023, Refereed
Last, Corresponding

Renal Function in Aged C57BL/6J Mice Is Impaired by Deposition of Age-Related Apolipoprotein A-II Amyloid Independent of Kidney Aging.
Ying Li; Jian Dai; Fuyuki Kametani; Masahide Yazaki; Akihito Ishigami; Masayuki Mori; Hiroki Miyahara; Keiichi Higuchi
The American journal of pathology, 193(6), 725-739, Mar. 2023, Refereed

Cyba and Nox2 mutant rats show different incidences of eosinophilia in the genetic background- and sex-dependent manner
Masayuki Mori; Jian Dai; Hiroki Miyahara; Ying Li; Xiaojing Kang; Kazuto Yoshimi; Tomoji Mashimo; Keiichi Higuchi; Kiyoshi Matsumoto
Experimental Animals, 72(2), 233-241, 2023
Lead, Corresponding

Macrophages in the reticuloendothelial system inhibit early induction stages of mouse apolipoprotein A-II amyloidosis
Hiroki Miyahara; Jian Dai; Ying Li; Xiaoran Cui; Hibiki Takeuchi; Naomi Hachiya; Fuyuki Kametani; Masahide Yazaki; Masayuki Mori; Keiichi Higuchi
Amyloid, 30(2), 225-238, Dec. 2022, Refereed

A Novel Hypothesis on the Molecular Pathogenesis of Porphyria that is Deduced from Studies of a Unique Model Mouse
Mori Masayuki
Shinshu Medical Journal, 70(3), 137-144, Jun. 2022
Lead, Corresponding

Exercise suppresses mouse systemic AApoAII amyloidosis through enhancement of the p38 MAPK signaling pathway
Cui X., Sawashita J., Dai J., Liu C., Igarashi Y., Mori M., Miyahara H., Higuchi K.
Dis. Model Mech., 15(3), dmm049327, 2022, Refereed, Not invited

Involvement of increased endoplasmic reticulum stress in the development of cataracts in BALB.NCT-Cpoxnct mice
Liu C., Miyahara H., Dai J., Cui X., Li Y., Kang X., Higuchi K., Mori M.
Exp. Eye Res., 215, 108905-108905, 2022, Refereed, Not invited
Last, Corresponding

Polygenic control of the wavy coat of the NCT mouse: involvement of an intracisternal A particle insertional mutation of the protease, serine 53 (Prss53) gene, and a modifier gene
Mori M., Liu C., Yoshizawa T., Miyahara H., Dai J., Igarashi Y., Cui X., Li Y., Kang X., Higuchi K.
Mamm. Genome, 33(3), 451-464, 2022, Refereed, Not invited
Lead, Corresponding

Glavonoid-rich oil supplementation reduces stearoyl-coenzyme A desaturase 1 expression and improves systemic metabolism in diabetic, obese KK-Ay mice
Igarashi Y., Iida S., Dai J., Huo J., Cui X., Sawashita J., Mori M., Miyahara H., Higuchi K.
Biomed. Pharmacother., 140, 111714-111714, 2021, Refereed, Not invited

Curcumin promotes AApoAII amyloidosis and peroxisome proliferation in mice by activating the PPARα signaling pathway
Dai J., Li Y., Kametani F., Cui X., Igarashi Y., Huo J., Miyahara H., Mori M., Higuchi K.
eLife, 10, e63538, 2021, Refereed

老化モデル動物を用いたエージング研究
樋口京一, 森 政之
ファルマシア, 56(11), 1004-1008, 2020, Invited
Last, Corresponding

[The senescence-accelerated mouse as a model for geriatrics and aging biology].
Masayuki Mori; Keiichi Higuchi
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 153(4), 179-185, 2019

Suppression of mouse AApoAII amyloidosis progression by daily supplementation with oxidative stress inhibitors.
Dai J., Ding X., Miyahara H., Xu Z., Cui X., Igarashi Y., Sawashita J., Mori M., Higuchi K.
Oxidative medicine and cellular longevity, 2019, 1263274-1263274, 2019, Refereed, Not invited

Apolipoprotein A-II induces acute-phase response associated AA amyloidosis in mice through conformational changes of plasma lipoprotein structure
Mu Yang; Yingye Liu; Jian Dai; Lin Li; Xin Ding; Zhe Xu; Masayuki Mori; Hiroki Miyahara; Jinko Sawashita; Keiichi Higuchi
Scientific Reports, 8(1), 5620, Dec. 2018, Refereed, Not invited

Comprehensive proteomic profiles of mouse AApoAII amyloid fibrils provide insights into the involvement of lipoproteins in the pathology of amyloidosis
Hiroki Miyahara; Jinko Sawashita; Eri Ishikawa; Mu Yang; Xin Ding; Yingye Liu; Naomi Hachiya; Fuyuki Kametani; Masahide Yazaki; Masayuki Mori; Keiichi Higuchi
Journal of Proteomics, 172, 111-121, Feb. 2018, Refereed, Not invited

Coenzyme Q10 prevents senescence and dysfunction caused by oxidative stress in vascular endothelial cells
Huo J., Xu Z., Hosoe K., Kubo H., Miyahara H., Dai J., Mori M., Sawashita J., Higuchi K.
Oxid. Med. Cell. Longev., 2018, 3181759-3181759, 2018, Refereed

Amyloidosis-inducing activity of blood cells in mouse aapoaii amyloidosis
Xin Ding; Yingye Liu; Mu Yang; Lin Li; Hiroki Miyahara; Jian Dai; Zhe Xu; Kiyoshi Matsumoto; Masayuki Mori; Keiichi Higuchi; Jinko Sawashita
Experimental Animals, 67(2), 105-115, 2018, Refereed, Not invited

Coenzyme Q10 Improves Lipid Metabolism and Ameliorates Obesity by Regulating CaMKII-Mediated PDE4 Inhibition
Zhe Xu; Jia Huo; Xin Ding; Mu Yang; Lin Li; Jian Dai; Kazunori Hosoe; Hiroshi Kubo; Masayuki Mori; Keiichi Higuchi; Jinko Sawashita
SCIENTIFIC REPORTS, 7(1), 8253, Aug. 2017, Refereed, Not invited

Apolipoprotein A-II accelerates reactive AA amyloidosis
Mu Yang; Yingye Liu; Lin Li; Hiroki Miyahara; Xin Ding; Jian Dai; Jinko Sawashita; Masayuki Mori; Keiichi Higuchi
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 24, 147-148, Mar. 2017, Refereed, Not invited

Caloric restriction reduces the systemic progression of mouse AApoAII amyloidosis
Lin Li; Jinko Sawashita; Xin Ding; Mu Yang; Zhe Xu; Hiroki Miyahara; Masayuki Mori; Keiichi Higuchi
PLOS ONE, 12(2), e0172402, Feb. 2017, Refereed, Not invited

A nonsense nucleotide substitution in the oculocutaneous albinism II gene underlies the original pink-eyed dilution allele (Oca2(p)) in mice
Haruka Shoji; Yukiko Kiniwa; Ryuhei Okuyama; Mu Yang; Keiichi Higuchi; Masayuki Mori
EXPERIMENTAL ANIMALS, 64(2), 171-179, Apr. 2015, Refereed, Not invited
Corresponding

The factors affecting adherence to a long-term interval walking training program in middle-aged and older people
Shizue Masuki; Masayuki Mori; Yasuharu Tabara; Akihiro Sakurai; Shigenari Hashimoto; Mayuko Morikawa; Ken Miyagawa; Eri Sumiyoshi; Tetsuro Miki; Keiichi Higuchi; Hiroshi Nose
JOURNAL OF APPLIED PHYSIOLOGY, 118(5), 595-603, Mar. 2015, Refereed, Not invited

Extracellular deposition of mouse senile AApoAII amyloid fibrils induced different unfolded protein responses in the liver, kidney, and heart
Hongmin Luo; Jinko Sawashita; Geng Tian; Yingye Liu; Lin Li; Xin Ding; Zhe Xu; Mu Yang; Hiroki Miyahara; Masayuki Mori; Jinze Qian; Yaoyong Wang; Keiichi Higuchi
LABORATORY INVESTIGATION, 95(3), 320-333, Mar. 2015, Refereed, Not invited

C-terminal sequence of amyloid-resistant type F apolipoprotein A-II inhibits amyloid fibril formation of apolipoprotein A-II in mice
Jinko Sawashita; Beiru Zhang; Kazuhiro Hasegawa; Masayuki Mori; Hironobu Naiki; Fuyuki Kametani; Keiichi Higuchi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 112(8), E836-E845, Feb. 2015, Refereed, Not invited

Novel frame-shift mutation in S1c5a2 encoding SGLT2 in a strain of senescence-accelerated mouse SAMP10
Keiko Unno; Hiroyuki Yamamoto; Masateru Toda; Shiori Hagiwara; Kazuaki Iguchi; Minoru Hoshino; Fumiyo Takabayashi; Sanae Hasegawa-Ishii; Atsuyoshi Shimada; Masanori Hosokawa; Keiichi Higuchi; Masayuki Mori
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 454(1), 89-94, Nov. 2014, Refereed, Not invited

Ubiquinol-10 Supplementation Activates Mitochondria Functions to Decelerate Senescence in Senescence-Accelerated Mice
Geng Tian; Jinko Sawashita; Hiroshi Kubo; Shin-ya Nishio; Shigenari Hashimoto; Nobuyoshi Suzuki; Hidekane Yoshimura; Mineko Tsuruoka; Yaoyong Wang; Yingye Liu; Hongming Luo; Zhe Xu; Masayuki Mori; Mitsuaki Kitano; Kazunori Hosoe; Toshio Takeda; Shin-ichi Usami; Keiichi Higuchi
ANTIOXIDANTS & REDOX SIGNALING, 20(16), 2606-2620, Jun. 2014, Refereed, Not invited

AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform
Masayuki Mori; Geng Tiang; Keiichi Higuchi
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 21(1), 1-8, Mar. 2014, Refereed, Not invited

Diversity and Complexity of the Mouse Saa1 and Saa2 genes
Masayuki Mori; Geng Tian; Akira Ishikawa; Keiichi Higuchi
EXPERIMENTAL ANIMALS, 63(1), 99-106, Jan. 2014, Refereed, Not invited
Lead, Corresponding

Specific mtDNA Mutations in Mouse Carcinoma Cells Suppress Their Tumor Formation via Activation of the Host Innate Immune System
Hirotake Imanishi; Gaku Takibuchi; Toshihiko Kobayashi; Kaori Ishikawa; Kazuto Nakada; Masayuki Mori; Yoshiaki Kikkawa; Keizo Takenaga; Noriko Toyama-Sorimachi; Jun-Ichi Hayashi
PLOS ONE, 8(9), UNSP e75981, Sep. 2013, Refereed, Not invited

Hereditary cataract of the Nakano mouse: Involvement of a hypomorphic mutation in the coproporphyrinogen oxidase gene
Masayuki Mori; Saki Gotoh; Shigeru Taketani; Hiroshi Hiai; Keiichi Higuchi
EXPERIMENTAL EYE RESEARCH, 112, 45-50, Jul. 2013, Refereed, Not invited

An interleukin-33 gene polymorphism is a modifier for eosinophilia in rats
H. Luo; K. Higuchi; K. Matsumoto; M. Mori
GENES AND IMMUNITY, 14(3), 192-197, Apr. 2013, Refereed, Not invited

Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes
Kumpei Tanisawa; Eri Mikami; Noriyuki Fuku; Yoko Honda; Shuji Honda; Ikuro Ohsawa; Masafumi Ito; Shogo Endo; Kunio Ihara; Kinji Ohno; Yuki Kishimoto; Akihito Ishigami; Naoki Maruyama; Motoji Sawabe; Hiroyoshi Iseki; Yasushi Okazaki; Sanae Hasegawa-Ishii; Shiro Takei; Atsuyoshi Shimada; Masanori Hosokawa; Masayuki Mori; Keiichi Higuchi; Toshio Takeda; Mitsuru Higuchi; Masashi Tanaka
BMC GENOMICS, 14, 248, Apr. 2013, Refereed, Not invited

Cheetahs have 4 serum amyloid a genes evolved through repeated duplication events.
Chen L; Une Y; Higuchi K; Mori M
The Journal of heredity, 103, 115-129, Jan. 2012, Refereed, Not invited

ApoA-I deficiency in mice is associated with redistribution of apoA-II and aggravated AApoAII amyloidosis
Yaoyong Wang; Jinko Sawashita; Jinze Qian; Beiru Zhang; Xiaoying Fu; Geng Tian; Lei Chen; Masayuki Mori; Keiichi Higuchi
JOURNAL OF LIPID RESEARCH, 52(8), 1461-1470, Aug. 2011, Refereed, Not invited

Genes for Difference in Eosinophilic Phenotype between MES and BN.MES-Cyba(mes) Rats Are on Chromosomes 9, 5, and 1
Hiroshi Tomozawa; Ayako Nishio; Keiichi Higuchi; Kiyoshi Matsumoto; Masayuki Mori
EXPERIMENTAL ANIMALS, 60(2), 151-160, Apr. 2011, Not invited
Corresponding

Nuclear but not mitochondrial DNA involvement in respiratory complex I defects found in senescence-accelerated mouse strain, SAMP8.
Hirotake Imanishi; Mutsumi Yokota; Masayuki Mori; Akinori Shimizu; Kazuto Nakada; Jun-Ichi Hayashi
Experimental animals, 60(4), 397-404, 2011, Not invited

The Reduced Form of Coenzyme Q(10) Mediates Distinct Effects on Cholesterol Metabolism at the Transcriptional and Metabolite Level in SAMP1 Mice
Constance Schmelzer; Juergen G. Okun; Dorothea Haas; Keiichi Higuchi; Jinko Sawashita; Masayuki Mori; Frank Doering
IUBMB LIFE, 62(11), 812-818, Nov. 2010, Not invited

Exercise Effects on Methylation of ASC Gene
K. Nakajima; M. Takeoka; M. Mori; S. Hashimoto; A. Sakurai; H. Nose; K. Higuchi; N. Itano; M. Shiohara; T. Oh; S. Taniguchi
INTERNATIONAL JOURNAL OF SPORTS MEDICINE, 31(9), 671-675, Sep. 2010, Not invited

Mouse model to study human A beta M-2 amyloidosis: generation of a transgenic mouse with excessive expression of human beta(2)-microglobulin
Pengyao Zhang; Xiaoying Fu; Jinko Sawashita; Junjie Yao; Beiru Zhang; Jinze Qian; Hiroshi Tomozawa; Masayuki Mori; Yukio Ando; Hironobu Naiki; Keiichi Higuchi
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 17(2), 50-62, Jun. 2010, Not invited

Supplementation with the reduced form of Coenzyme Q(10) decelerates phenotypic characteristics of senescence and induces a peroxisome proliferator-activated receptor-alpha gene expression signature in SAMP1 mice
Constance Schmelzer; Hiroshi Kubo; Masayuki Mori; Jinko Sawashita; Mitsuaki Kitano; Kazunori Hosoe; Inka Boomgaarden; Frank Doering; Keiichi Higuchi
MOLECULAR NUTRITION & FOOD RESEARCH, 54(6), 805-815, Jun. 2010, Not invited

Mouse Senile Amyloid Fibrils Deposited in Skeletal Muscle Exhibit Amyloidosis-Enhancing Activity
Jinze Qian; Jingmin Yan; Fengxia Ge; Beiru Zhang; Xiaoying Fu; Hiroshi Tomozawa; Jinko Sawashita; Masayuki Mori; Keiichi Higuchi
PLOS PATHOGENS, 6(5), May 2010, Not invited

BN.MES-Cybames congenic rats manifest focal necrosis with eosinophilic infiltration in the liver without blood eosinophilia
Hiroshi Tomozawa; Ayako Nishio; Yuji Okuhara; Keiichi Higuchi; Kiyoshi Matsumoto; Masayuki Mori
Experimental Animals, 59(4), 469-478, 2010, Not invited

Genetic basis of inter-individual variability in the effects of exercise on the alleviation of lifestyle-related diseases
Masayuki Mori; Keiichi Higuchi; Akihiro Sakurai; Yasuharu Tabara; Tetsuro Miki; Hiroshi Nose
JOURNAL OF PHYSIOLOGY-LONDON, 587(23), 5577-5584, Dec. 2009, Not invited

Amyloid fibrils formed by selective N-, C-terminal sequences of mouse apolipoprotein A-II
Jinko Sawashita; Fuyuki Kametani; Kazuhiro Hasegawa; Shinobu Tsutsumi-Yasuhara; Beiru Zhang; Jingmin Yan; Masayuki Mori; Hironobu Naiki; Keiichi Higuchi
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1794(10), 1517-1529, Oct. 2009, Not invited

Pivotal Advance: Eosinophilia in the MES rat strain is caused by a loss-of-function mutation in the gene for cytochrome b(-245), alpha polypeptide (Cyba)
Masayuki Mori; Guixin Li; Maiko Hashimoto; Ayako Nishio; Hiroshi Tomozawa; Nobuyoshi Suzuki; Shin-ichi Usami; Keiichi Higuchi; Kiyoshi Matsumoto
JOURNAL OF LEUKOCYTE BIOLOGY, 86(3), 473-478, Sep. 2009, Not invited

Effect of Dietary Unsaturated Fatty Acids on Senile Amyloidosis in Senescence-Accelerated Mice
Makiko Umezawa; Keiichi Higuchi; Masayuki Mori; Takatoshi Matushita; Masanori Hosokawa
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 64(6), 646-652, Jun. 2009, Not invited

Dysfunction in ABCB1A has only a weak effect on susceptibility to dextran sulfate sodium-induced colitis in SAM strains
Guohong Zhang; Xiaoying Fu; Toshio Takeda; Keiichi Higuchi; Masayuki Mori
Experimental Animals, 58(4), 421-425, 2009, Not invited

Hereditary pancreatitis model WBN/Kob rat strain has a unique haplotype in the Pdwk1 region on chromosome 7
Masayuki Mori; Xiaoying Fu; Lei Chen; Guohong Zhang; Keiichi Higuchi
Experimental Animals, 58(4), 409-413, 2009, Not invited

Senescence-Accelerated Mouse (SAM) strains have a spontaneous mutation in the Abcb1a gene
Guohong Zhang; Beiru Zhang; Xiaoying Fu; Hiroshi Tomozawa; Kiyoshi Matsumoto; Keiichi Higuchi; Masayuki Mori
EXPERIMENTAL ANIMALS, 57(4), 413-417, Jul. 2008, Not invited
Corresponding

Characterization of the cheetah serum amyloid A1 gene: Critical role and functional polymorphism of a Cis-acting element
Beiru Zhang; Yumi Une; Fengxia Ge; Xiaoying Fu; Jinze Qian; Pengyao Zhang; Jinko Sawashita; Keiichi Higuchi; Masayuki Mori
JOURNAL OF HEREDITY, 99(4), 355-363, Jul. 2008, Not invited
Corresponding

Fecal transmission of AA amyloidosis in the cheetah contributes to high incidence of disease
Beiru Zhang; Yumi Une; Xiaoying Fu; Jingmin Yan; FengXia Ge; Junjie Yao; Jinko Sawashita; Masayuki Mori; Hiroshi Tomozawa; Fuyuki Kametani; Keiichi Higuchi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(20), 7263-7268, May 2008, Not invited

Cross-seeding and cross-competition in mouse apolipoprotein A-II amyloid fibrils and protein A amyloid fibrils
Jingmin Yan; Xiaoying Fu; Fengxia Ge; Beiru Zhang; Junjie Yao; Huanyu Zhang; Jinze Qian; Hiroshi Tomozawa; Hironobu Naiki; Jinko Sawashita; Masayuki Mori; Keiichi Higuchi
AMERICAN JOURNAL OF PATHOLOGY, 171(1), 172-180, Jul. 2007, Not invited

Amyloidosis in transgenic mice expressing murine amyloidogenic apolipoprotein A-II (Apoa2(c))
Fengxia Ge; Junjie Yao; Xiaoying Fu; Zhanjun Guo; Jingmin Yan; Beiru Zhang; Huanyu Zhang; Hiroshi Tomozawa; Junichi Miyazaki; Jinko Sawashita; Masayuki Mori; Keiichi Higuchi
LABORATORY INVESTIGATION, 87(7), 633-643, Jul. 2007, Not invited

Quantitative trait locus that determines the cross-sectional shape of the femur in SAMP6 and SAMP2 mice
Bungo Otsuki; Takuro Matsumura; Motoyuki Shimizu; Masayuki Mori; Shuzo Okudaira; Rika Nakanishi; Keiichi Higuchi; Masanori Hosokawa; Tadao Tsuboyama; Takashi Nakamura
JOURNAL OF BONE AND MINERAL RESEARCH, 22(5), 675-685, May 2007, Not invited

Functional polymorphisms of the Lss and Fdft1 genes in laboratory rats
Masayuki Mori; Jinko Sawashita; Keiichi Higuchi
EXPERIMENTAL ANIMALS, 56(2), 93-101, Apr. 2007, Not invited
Lead, Corresponding

Mouse senile amyloidosis: Possible horizontal transmission in the mouse room
X. Fu; T. Korenaga; J. Yan; F. Ge; B. Zhang; J. Qian; H. Naiki; J. Sawashita; M. Mori; K. Higuchi
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 13, 29-29, Nov. 2006, Not invited

Secreted frizzled-related protein 4 is a negative regulator of peak BMD in SAMP6 mice
Rika Nakanishi; Motoyuki Shimizu; Masayuki Mori; Haruhiko Akiyama; Shuzo Okudaira; Bungo Otsuki; Maiko Hashirnoto; Keiichi Higuchi; Masanori Hosokawa; Tadao Tsuboyama; Takashi Nakamura
JOURNAL OF BONE AND MINERAL RESEARCH, 21(11), 1713-1721, Nov. 2006, Not invited

A third locus for Eosinophilia on chromosome 1 of the MES rats
Masayuki Mori; Keiichi Higuchi; Kiyoshi Matsumoto
EXPERIMENTAL ANIMALS, 55(5), 497-500, Oct. 2006, Refereed, Not invited
Lead, Corresponding

Transmissibility of mouse AApoAII amyloid fibrils: inactivation by physical and chemical methods
Huanyu Zhang; Jinko Sawashita; Xiaoying Fu; Tatsumi Korenaga; Jingmin Yan; Masayuki Mori; Keiichi Higuchi
FASEB JOURNAL, 20(7), 1012-+, May 2006, Not invited

Transmission of amyloidosis in offspring of mice with AApoAII amyloidosis
T Korenaga; JM Yan; J Sawashita; T Matsushita; H Naiki; M Hosokawa; M Mori; K Higuchi; XY Fu
AMERICAN JOURNAL OF PATHOLOGY, 168(3), 898-906, Mar. 2006, Refereed, Not invited

Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice
J Yan; K Fujii; J Yao; H Kishida; K Hosoe; J Sawashita; T Takeda; M Mori; K Higuchi
EXPERIMENTAL GERONTOLOGY, 41(2), 130-140, Feb. 2006, Refereed, Not invited

Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat
M Mori; GX Li; Abe, I; J Nakayama; ZJ Guo; J Sawashita; T Ugawa; S Nishizono; T Serikawa; K Higuchi; S Shumiya
JOURNAL OF CLINICAL INVESTIGATION, 116(2), 395-404, Feb. 2006, Refereed, Not invited
Lead, Corresponding

A locus for eosinophilia in the MES rat is on Chromosome 19
GX Li; ZJ Guo; K Higuchi; M Kawakubo; K Matsumoto; M Mori
MAMMALIAN GENOME, 16(7), 516-523, Jul. 2005, Refereed, Not invited
Corresponding

Analysis of murine chromosomes 11 and 13 loci that control peak bone mass
M Shimizu; R Nakanishi; B Otsuki; T Nakamura; M Hosokawa; M Mori; K Higuchi; T Tsuboyama
BONE, 36, S398-S399, Jun. 2005, Not invited

Establishment of a set of combined immunodeficient DA/Slc-Foxn1(rnu) Lyst(bg) congenic rat strains
N Masui; T Nishikawa; Y Takagi; H Kimura; M Mori; S Yokose; H Asai; T Gonda; M Yanabe; K Sato
EXPERIMENTAL ANIMALS, 53(5), 399-407, Oct. 2004, Refereed, Not invited

Mouse testis transcriptome revealed using serial analysis of gene expression
JJ Yao; T Chiba; J Sakai; K Hirose; M Yamamoto; A Hada; K Kuramoto; K Higuchi; M Mori
MAMMALIAN GENOME, 15(6), 433-451, Jun. 2004, Refereed, Not invited
Corresponding

Tissue distribution, biochemical properties, and transmission of mouse type A AApoAII amyloid fibrils
T Korenaga; XY Fu; YM Xing; T Matsusita; K Kuramoto; S Syumiya; K Hasegawa; H Naiki; M Ueno; T Ishihara; M Hosokawa; M Mori; K Higuchi
AMERICAN JOURNAL OF PATHOLOGY, 164(5), 1597-1606, May 2004, Refereed, Not invited

Induction of AApoAII amyloidosis by various heterogeneous amyloid fibrils
XY Fu; T Korenaga; L Fu; YM Xing; ZJ Guo; T Matsushita; M Hosokawa; H Naiki; S Baba; Y Kawata; S Ikeda; T Ishihara; M Mori; K Higuchi
FEBS LETTERS, 563(1-3), 179-184, Apr. 2004, Refereed, Not invited

Genetic monitoring system for SAM strains utilizing DNA markers
Masayuki Mori; Keiichi Higuchi
International Congress Series, 1260(C), 187-190, Feb. 2004

Transmission of mouse AApoAII amyloidosis by the amyloid fibrils; inhibitory effects on transmission by the denaturation/degradation of amyloid fibrils
Jinko Sawashita; Huanyu Zhang; Xiaoying Fu; Tatsumi Korenaga; Masayuki Mori; Keiichi Higuchi
Amyloid and Amyloidosis, 457-459, Jan. 2004

An allele-specific genotyping method for rat Lyst (lysosomal trafficking regulator) gene
N Masui; M Mori; T Nishikawa; Y Takagi; H Asai; M Yanabe; KI Yamasaki; T Serikawa; K Sato
EXPERIMENTAL ANIMALS, 53(1), 77-80, Jan. 2004, Refereed, Not invited

Polymorphisms of mouse apolipoprotein A-II: seven alleles found among 41 inbred strains of mice
K Kitagawa; J Wang; T Mastushita; K Kogishi; M Hosokawa; XY Fu; ZJ Guo; M Mori; K Higuchi
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 10(4), 207-214, Dec. 2003, Refereed, Not invited

Spontaneous hypomorphic mutations in antioxidant enzymes of mice
ZJ Guo; K Higuchi; M Mori
FREE RADICAL BIOLOGY AND MEDICINE, 35(12), 1645-1652, Dec. 2003, Refereed, Not invited
Corresponding

Amyloidosis modifier genes in the less amyloidogenic A/J mouse strain
ZJ Guo; M Mori; XY Fu; JJ Yao; YM Xing; T Korenaga; GX Li; T Matsushita; M Hosokawa; K Higuchi
LABORATORY INVESTIGATION, 83(11), 1605-1613, Nov. 2003, Refereed, Not invited

The rat lysosomal trafficking regulator (Lyst) gene is mapped on the telomeric region of chromosome 17
N Masui; T Nishikawa; Y Takagi; M Mori; T Suzuki; K Sato
EXPERIMENTAL ANIMALS, 52(1), 89-91, Jan. 2003, Refereed, Not invited

Quantitative trait locus analysis of serum insulin, triglyceride, total cholesterol and phospholipid levels in the (SM/J x A/J)F-2 mice
RVP Anunciado; M Nishimura; M Mori; A Ishikawa; S Tanaka; F Horio; T Ohno; T Namikawa
EXPERIMENTAL ANIMALS, 52(1), 37-42, Jan. 2003, Refereed, Not invited

A new beige mutant rat ACI/N-Lyst(bg-Kyo)
M Mori; K Yamasaki; S Nakanishi; K Kitada; K Higuchi; C Namiki; S Hamada; T Serikawa
EXPERIMENTAL ANIMALS, 52(1), 31-36, Jan. 2003, Refereed, Not invited
Lead, Corresponding

多因子遺伝性疾患モデルとしての白内障ラットの解析
森 政之
信州医学雑誌, 51(2), 105-106, 2003
Lead, Corresponding

遺伝的解析のモデル生物、マウス
森 政之, 芹川忠夫
遺伝子医学別冊「これだけは知っておきたい遺伝子医学の基礎知識」, 154-158, 2003
Lead

Induction of protein conformational change in mouse senile amyloidosis
YM Xing; A Nakamura; T Korenaga; ZJ Guo; JJ Yao; XY Fu; T Matsushita; K Kogishi; M Hosokawa; F Kametani; M Mori; K Higuchi
JOURNAL OF BIOLOGICAL CHEMISTRY, 277(36), 33164-33169, Sep. 2002, Refereed, Not invited

A congenic mouse and candidate gene at the Chromosome 13 locus regulating bone density
M Shimizu; K Higuchi; S Kasai; T Tsuboyama; M Matsushita; T Matsumura; S Okudaira; M Mori; A Koizumi; T Nakamura; M Hosokawa
MAMMALIAN GENOME, 13(7), 335-340, Jul. 2002, Refereed, Not invited

老化疾患モデルマウス
森 政之, 樋口京一
Molecular Medicine, 39(5), 528-533, 2002

Chediak-Higashi症候群とベージュミュータント動物
森 政之
別冊・医学のあゆみ 免疫疾患-state of arts ver. 2, 303-306, 2002
Lead, Corresponding

老化疾患モデル ーマウス
森 政之, 樋口京一
現代医療, 34(2), 37-42, 2002
Lead, Corresponding

Chromosome 13 locus, Pbd2, regulates bone density in mice
M Shimizu; K Higuchi; S Kasai; T Tsuboyama; M Matsushita; M Mori; Y Shimizu; T Nakamura; M Hosokawa
JOURNAL OF BONE AND MINERAL RESEARCH, 16(11), 1972-1982, Nov. 2001, Refereed, Not invited

Quantitative trait loci for body weight in the intercross between SM/J and A/J mice
RVP Anunciado; M Nishimura; M Mori; A Ishikawa; S Tanaka; F Hori; T Ohno; T Namikawa
EXPERIMENTAL ANIMALS, 50(4), 319-324, Jul. 2001, Refereed, Not invited

Unique mutations in mitochondrial DNA of senescence-accelerated mouse (SAM) strains
J Mizutani; T Chiba; M Tanaka; K Higuchi; M Mori
JOURNAL OF HEREDITY, 92(4), 352-355, Jul. 2001, Not invited
Corresponding

Extrahepatic expression of apolipoprotein A-II in mouse tissues: Possible contribution to mouse senile amyloidosis
L Fu; Matsuyama, I; T Chiba; YM Xing; T Korenaga; ZJ Guo; XY Fu; J Nakayama; M Mori; K Higuchi
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 49(6), 739-747, Jun. 2001, Not invited

Extrahepatic expression of apolipoprotein A-II in mouse tissues: Possible contribution to mouse senile amyloidosis
L Fu; Matsuyama, I; T Chiba; YM Xing; T Korenaga; ZJ Guo; XY Fu; J Nakayama; M Mori; K Higuchi
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 49(6), 739-747, Jun. 2001, Not invited

Quantitative trait locus analysis for chronic pancreatitis and diabetes mellitus in the WBN/Kob rat
A Tsuji; T Nishikawa; M Mori; K Suda; Nishimori, I; M Nishimura
GENOMICS, 74(3), 365-369, Jun. 2001, Not invited

Spontaneous loss-of-function mutations of the 8-oxoguanine DNA glycosylase gene in mice and exploration of the possible implication of the gene in senescence
M Mori; S Toyokuni; S Kondo; H Kasai; H Naiki; E Toichi; M Hosokawa; K Higuchi
FREE RADICAL BIOLOGY AND MEDICINE, 30(10), 1130-1136, May 2001, Not invited
Lead, Corresponding

Transmission of mouse senile amyloidosis
YM Xing; A Nakamura; T Chiba; K Kogishi; T Matsushita; F Li; ZJ Guo; M Hosokawa; M Mori; K Higuchi
LABORATORY INVESTIGATION, 81(4), 493-499, Apr. 2001, Not invited

マウスを用いた老化・寿命の分子遺伝学的研究
森 政之, 樋口京一
基礎老化研究, 25(2), 77-82, 2001
Lead, Corresponding

遺伝性銅代謝異常症のモデルマウス・ラット
森 政之
臨床検査, 45(7), 754-757, 2001
Lead, Corresponding

老化促進マウス（SAM）の解析
樋口京一, 森 政之
BIO Clinica, 16(9), 57-61, 2001

Transmission of mouse senile amyloidosis
Xing, YM; Nakamura, A; Chiba, T; Korenaga, T; Kogishi, K; Matsushita, T; Fu, L; Guo, ZJ; Hosokawa, M; Mori, M; Higuchi, K
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 8, 22-22, 2001

Wild type ApoA-II gene does not rescue senescence-accelerated mouse (SAMP1) from short life span and accelerated mortality
J Wang; T Matsushita; K Kogishi; C Xia; A Ohta; T Chiba; A Nakamura; H Kondo; M Mori; M Hosokawa; K Higuchi
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 55(9), B432-B439, Sep. 2000, Not invited

Wild type ApoA-II gene does not rescue senescence-accelerated mouse (SAMP1) from short life span and accelerated mortality
J Wang; T Matsushita; K Kogishi; C Xia; A Ohta; T Chiba; A Nakamura; H Kondo; M Mori; M Hosokawa; K Higuchi
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 55(9), B432-B439, Sep. 2000, Not invited

Genetic analysis of lifespan in hybrid progeny derived from the SAMP1 mouse strain with accelerated senescence
Z Guo; E Toichi; M Hosono; T Hosokawa; M Hosokawa; K Higuchi; M Mori
MECHANISMS OF AGEING AND DEVELOPMENT, 118(1-2), 35-44, Sep. 2000, Not invited
Corresponding

Distribution of body weight, blood insulin and lipid levels in the SMXA recombinant inbred strains and the QTL analysis
RVP Anunciado; T Ohno; M Mori; A Ishikawa; S Tanaka; F Horio; M Nishimura; T Namikawa
EXPERIMENTAL ANIMALS, 49(3), 217-224, Jul. 2000, Refereed, Not invited

Deletion in the beige gene of the beige rat owing to recombination between LINE1s
M Mori; T Nishikawa; K Higuchi; M Nishimura
MAMMALIAN GENOME, 10(7), 692-695, Jul. 1999, Refereed, Not invited
Lead, Corresponding

Genetic profile of the SMXA recombinant inbred mouse strains revealed with restriction landmark genomic scanning
M Mori; S Akiyoshi; Y Mizuno; H Okuizumi; Y Okazaki; Y Hayashizaki; M Nishimura
MAMMALIAN GENOME, 9(9), 695-709, Sep. 1998, Not invited
Lead, Corresponding

わが国が貢献したマウスラットの疾患遺伝子の情報
森 政之, 西村正彦, 西川 哲
アニテックス, 10(2), 25-29, 1998
Lead, Corresponding

Reply from M. Mori, K. Higuchi and H. Nose
Masayuki Mori; Keiichi Higuchi; Hiroshi Nose
Journal of Physiology, 588(6), 1025, Mar. 2010

β₂-microglobulinのtransgenicマウスの作成とアミロイド沈着の解析
樋口 京一; 付 笑影; 葛 鳳霞; 張 蓓茹; 銭 金澤; 澤下 仁子; 森 政之; 内木 宏延
厚生労働科学研究費補助金難治性疾患克服研究事業アミロイドーシスに関する調査研究平成18年度総括・分担研究報告書, 93 - 97, 2007, Not invited

マウス老化アミロイドーシス関連タンパク質apoA-Ⅱのアミロイド線維形成機構
樋口 京一; 澤下 仁子; 長谷川 一浩; 安原(堤) しのぶ; 森 政之; 葛 鳳霞; 姚 俊潔; 内木 宏延
厚生労働科学研究費補助金難治性疾患克服研究事業アミロイドーシスに関する調査研究平成18年度総括・分担研究報告書, 107 - 111, 2007, Not invited

モデル動物の作製と利用－循環器疾患2021＜下巻＞
樋口京一; 森 政之, Contributor, 腎アミロイドーシス
エル・アイ・シー, 2021

老化の生物学
樋口京一; 森 政之, Contributor, 老化のモデル生物が果たす役割
化学同人, 2014

腸内フローラと加齢
樋口京一; 田 耕; 澤下仁子; 森 政之; 細川昌則; 竹田俊男, Contributor, 老化促進モデルマウス(SAM)を用いた老化研究および抗老化研究
医薬出版, 2013

The Senescence-Accelerated Mouse (SAM): Achievements and future directions.
Mori M.; Higuchi K., Contributor, Genetic profile of SAM strains. b. Microsatellite markers
ELSEVIER, 2013

The Senescence-Accelerated Mouse (SAM): Achievements and future directions.
Mori M.; Higuchi K., Contributor, Genetic profile of SAM strains. a. Biochemical and immunogenetic markers
ELSEVIER, 2013

The Senescence-Accelerated Mouse (SAM): Achievements and future directions.
Mori M.; Higuchi K., Contributor, Genetic characteristics of SAM strains
ELSEVIER, 2013

Biophysical Inquiry into Protein Aggregation and Amyloid Diseases
Higuchi, K., Fu, X., Zhang, B., Sawashita J, Mori, M., Joint work, Genetics and transmission of mouse systemic amyloidosis
Research SignPost, 253-267 2008

XIth International Symposium on Amyloidosis
Higuchi, K., Ge, F., Fu, X., Yao, J., Zhan, B., Zhan, H., Qian, J., Sawashita, J., Mori, M., Joint work, Amyloidosis in the transgenic mice of mouse amyloidgenic apolipoprotein A-II (Apoa2C)
CRC Press, 143-145 2007

XIth International Symposium on Amyloidosis
Fu, X., Korenaga, T., Yan, J., Ge, F., Zhan, B., Qian, J., Naiki, H., Sawashita, J., Mori, M., Higuchi, K., Joint work, Mouse senile amyloidosis: possible horizontal transmission in the mouse room
CRC Press, 10-12 2007

Transmission of Mouse AApoAII Amyloidosis from Mother to Pups. Grateau G, Kyle RA, Skinner eds: Amyloid and Amyloidosis
Korenaga T, Fu X, Mori M, Sawashita J, Naiki H, Matsushita T, Higuchi K, Joint work
CRC Press, Boca Raton,, pp 457-459 2005

Transmission of Mouse AApoAII Amyloidosis by the Amyloid Fibrils; Inhibitory Effects on Transmission by the Denaturation/Degradation of Amyloid FibrilsGrateau G, Kyle RA, Skinner M eds: Amyloid and Amyloidosis
Sawashita J, Zhang H, Fu X, Korenaga T, Mori M, Higuchi K, Joint work
CRC Press, Boca Raton, pp 457-459 2005

モデル動物の作製と維持
森脇和郎、山村研一、米川博通編, Joint work
エル・アイ・シー，東京, 929-936 2004

森脇和郎，山村研一，米川博通編：モデル動物の作製と維持
樋口京一,森 政之, Joint work, SAM(老化促進モデルマウス)
エル・アイ・シー，東京, pp 929-936 2004

Nomura Y, Takeda T, Okuma Y ed.: The Senescence-Accelerated Mouse(SAM): An animal model of senescence
Fu X, Korenaga T, Xing Y, Fu L, Guo Z, Matsushita T, Hosokawa M, Naiki H, Mori M, Higuchi K, Joint work, Induction of AApoAⅡ and AA amyloidosis by the injection of various amyloid fibrils
Elsevier, Amsterdam, pp 383-386 2004

Nomura Y, Takeda T, Okuma Y ed.: The Senescence-Accelerated Mouse(SAM): An animal model of senescence
Mori M, Higuchi K, Joint work, Genetic monitoring system for SAM strains utilizing DNA markers
Elsevier, Amsterdam, pp 187-190 2004

Nomura Y, Takeda T, Okuma Y ed.: The Senescence-Accelerated Mouse(SAM): An animal model of senescence
Higuchi K, Xing Y, Fu X, Korenaga T, Guo Z, Nakamura A, Mori M, Joint work, Mouse senile amyloidosis in the SAM model
Elsevier, Amsterdam, pp 35-40 2004

老年医学テキスト
社団法人日本老年医学会編, Joint work
メジカルビュー社, 17-19 2003

老化促進モデルマウス(SAM)学会

日本実験動物学会

Elucidation of biological functions of the NCBP3 RNA-binding protein using a novel mutant mouse strain
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
01 Apr. 2022 - 31 Mar. 2025

Elucidation of pathoetiology of porphyria by using a mouse model
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
01 Apr. 2019 - 31 Mar. 2022

Validation of life extension effect of reduced form Coenzyme Q10
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Research (Exploratory)
Shinshu University
30 Jun. 2017 - 31 Mar. 2021

Integrative pathology of Amyloidosis: Exploratory research on the basis of transmission phenomena
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
Shinshu University
01 Apr. 2017 - 31 Mar. 2020

Elucidation of etiology of age-related cataracts by using Cpox mutant mouse strains
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
01 Apr. 2016 - 31 Mar. 2019

Development of preventive and therapeutic treatments based on the pathogenesis of the transmission of amyloidosis
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
Shinshu University
01 Apr. 2014 - 31 Mar. 2017

Generation of novel inflammatory disease model caused by dysregulation of IL-1 signaling
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
The University of Tokyo
01 Apr. 2012 - 31 Mar. 2015

Identification of genes for ulcerative colitis utilizing SAM mice
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
01 Apr. 2012 - 31 Mar. 2015

Pathological Investigation of the Pathogenesis and Development of Preventive and Therapeutic Procedures for Amyloidosis
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
Shinshu University
01 Apr. 2011 - 31 Mar. 2014

Molecular genetic analysis of hybrid vigor and inbreeding depression utilizing recombinant inbred mouse strains
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research
Shinshu University
2009 - 2011

Health promotional effects of the combination of supplementation and exercise in old mice having various genetic backgrounds
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
2009 - 2011

Systemic analysis of amyloidosis using animal models
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
Shinshu University
2008 - 2010

Characterization of SAM mice as an ulcerative colitis model
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
Shinshu University
2007 - 2009

Study on pathogenesis of eosionophilia with MES congenic rat developing human eosinophilia
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
2005 - 2007

Investigation into the pathogenesis of amyloidosis using the newly developed animal models.
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
Shinshu University
2005 - 2007

熟年体育大学を基盤とした運動効率関連遺伝子の探策
科学研究費助成事業, 日本学術振興会, 萌芽研究
信州大学
2005 - 2006

Generation of hypomorphic model mice utilizing an mRNA instability element
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
SHINSHU UNIVERSITY
2005 - 2006

病的構造タンパク質(アミロイド線維)の伝播及び形成機構の解析
科学研究費助成事業, 日本学術振興会, 特定領域研究
信州大学
2005 - 2006

病的構造タンパク質(アミロイド線維)の伝播及び形成機構の解析
科学研究費助成事業, 日本学術振興会, 特定領域研究
信州大学
2003 - 2004

アミロイド線維による伝播/感染機構と宿主応答の解析
科学研究費助成事業, 日本学術振興会, 特定領域研究
信州大学
2003 - 2003

新たに発見された活性型L1トランスポゾンを利用した突然変異マウス作出と遺伝子同定
科学研究費助成事業, 日本学術振興会, 特定領域研究
信州大学
2003 - 2003

Molecular Genetic Analysis of Senescence-Accelerated Mouse (SAM)
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
Shinshu University
2002 - 2004

新たに発見された活性型L1レトロトランスポゾンの実験病理学への応用
科学研究費助成事業, 日本学術振興会, 萌芽研究
信州大学
2002 - 2003

Analysis and application of newly discovered rat L1 retotransposon
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
2002 - 2003

アミロイドタンパク質の病的構造伝播機構の解析
科学研究費助成事業, 日本学術振興会, 特定領域研究
信州大学
2002 - 2002

新たに発見された活性型L1トランスポゾンを利用した突然変異マウス作出と遺伝子同定
科学研究費助成事業, 日本学術振興会, 特定領域研究
信州大学
2002 - 2002

CONSTRUCTION OF FINE COMPARTIVE GENETIC MAPS FOR THE RAT AND IDENTIFICATION OF CAUSATIVE GENES IN NEUROLOGICAL MUTANT RATS
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A)
KYOTO UNIVERSITY
2000 - 2003

自然突然変異型OGG1を持つマウス群を用いたDNA酸化傷害と発がんとの関連の解明
科学研究費助成事業, 日本学術振興会, 特定領域研究(C)
信州大学
2000 - 2000

マウス個体老化の分子的把握:老化臓器の遺伝子発現レパートリィの作成
科学研究費助成事業, 日本学術振興会, 萌芽的研究
信州大学
1999 - 2000

Analysis of repair systems for oxidative DNA damage in Senescence-Accelerated Mouso
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C)
Shinshu University
1999 - 2000

Analysis of the mechanism of misfolding to amyloid protein using mouse amyloidosis
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B).
Shinshu University
1999 - 2000

Genetical Analyses of Diabetes Mellitus Associated with Pancreatitis in WBN/Kob Rats.
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B)
1997 - 1999

Development and utilization of recombinant inbred strains of mice.
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A)
Hamamatsu University School of Medicine
1995 - 1997

疾患モデル学

病態遺伝学（老化病態の分子生物学）