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今村 哲也  イマムラ テツヤ

教員組織学術研究院(医学系)電話番号
教育組織医学部 医学科 泌尿器科学FAX番号
職名助教メールアドレスimatetu@shinshu-u.ac.jp
住所〒390-8621 長野県松本市旭3-1-1ホームページURLhttp://www.shinshu-u.ac.jp/faculty/medicine/chair/urology/luts/index.html

更新日:2021/07/14

プロフィール

研究分野
再生医学 排尿機能学
キーワード:下部尿路医学
現在の研究課題
下部尿路医学
キーワード:間葉系幹細胞
所属学会
所属学会
日本再生医療学会
日本泌尿器科学会
日本排尿機能学会
日本人工臓器学会
日本獣医再生医療学会

所属学会役職担当
日本再生医療学会
日本排尿機能学会
学歴
出身大学院
2007 , 信州大学大学院 医学研究科 医学系専攻
2004 , 信州大学大学院 医科学研究科
2000 , 山梨大学大学院 工学研究科博士前期課程 化学生物工学専攻

出身学校・専攻等(大学院を除く)
1998 , 山梨大学工学部化学生物工学科

取得学位
医学博士 , 信州大学
受賞学術賞
2017 , The American Urological Association 2017 105th Annual Meeting BEST POSTER
2014 , 第11回泌尿器科再建再生研究会 研究会賞
2013 , International Journal of Urology Reviewers of the Year
2013 , 33rd Congress of The Société Internationale D’urologie BEST POSTER
2011 , 第8回泌尿器科再建再生研究会 研究会賞 受賞
2010 , 第7回泌尿器科再建再生研究会 研究会賞 受賞
2009 , 2009年度 第10回AKUA泌尿器科研究奨励賞 受賞
2008 , 第5回泌尿器科再建再生研究会 研究会賞 受賞
2008 , 平成19年度信州大学医学部 特別賞 受賞
2007 , JACK LAPIDES ESSAY CONTEST GRAND PRIZE , “IMPLANTED MOUSE BONE MARROW-DERIVED CELLS CAN RECONSTRUCT FUNCTIONAL SMOOTH MUSCLE LAYER-LIKE STRUCTURES IN COLD-INJURED URINARY BLADDER WALLS”
2006 , 第94回日本泌尿器科学会総会賞受賞 , 「障害を受けたマウス膀胱平滑筋に対する骨髄細胞筋内移植による平滑筋層再構築の試み」
2006 , 河邉賞 受賞
研究職歴等
研究職歴
2011- , 信州大学 医学部 下部尿路医学講座 助教
2010- , 信州大学 医学部 泌尿器科学教室 研究員
2007- , 信州大学 医学部 泌尿器科学教室泌尿器科学領域産学連携学講座 研究員

研究活動業績

研究業績(著書・
発表論文等)
書籍等出版物
Atala, A and Murphy, SV (eds) Perinatal Stem Cells
Springer Science + Business Media (New York) 2014
Author:Minagawa T, Imamura T, Ishizuka O, Nishizawa O


Embryonic Stem Cells - Recent Advances in Pluripotent Stem Cell-Based Regenerative Medicine
2011
Author:Imamura T


nTech 16
2011
Author:Imamura T


論文
Recovery of Cryo-injured Rabbit Urethras by Biofabricated C-shaped Adipose-derived Mesenchymal Cell Structures
信州医学雑誌,68(6):357-370 2020(Dec. 10)
Author:Silwal Gautam, Sudha; Imamura, Tetsuya; Shimamura, Mitsuru; Minagawa, Tomonori; Nakazawa, Masaki; Ogawa, Teruyuki; Ishizuka, Osamu


Biofabricated Structures Reconstruct Functional Urinary Bladders in Radiation-Injured Rat Bladders
TISSUE ENGINEERING PART A,24(21-22):1574-1587 2018(Nov. 01)
Author:Imamura Tetsuya, Shimamura Mitsuru, Ogawa Teruyuki, Minagawa Tomonori, Nagai Takashi, Gautam Sudha Silwal, Ishizuka Osamu,


Combined treatment with a β3-adrenergic receptor agonist and a muscarinic receptor antagonist inhibits detrusor overactivity induced by cold stress in spontaneously hypertensive rats.
Neurourology and Urodynamics,36(4):1026-1033 2017
Author:Imamura T, Ogawa T, Minagawa T, Nagai T, Suzuki T, Saito T, Yokoyama H, Nakazawa M, Ishizuka O


冷えストレス排尿筋過活動の機序におけるTRPA1の機能的役割の解明.
第22回日本排尿機能学会 2015(Sep. 11)
Author:今村哲也, 小川輝之, 皆川倫範, 永井 崇, 平形志朗, 横山 仁, 齊藤徹一, 中沢昌樹, 石塚 修


骨髄由来細胞シートによる放射線照射傷害膀胱の機能的な膀胱への再生とその機序解明の試み.
第14回日本再生医療学会総会 2015(Mar. 19)
Author:今村哲也, 小川輝之, 皆川倫範, 横山 仁, 石川雅邦, 永井 崇, 平形志朗, 中沢昌樹,石塚 修


シンポジウム12 前立腺肥大症の治療戦略 3.下部尿路閉塞に伴う膀胱におけるトランスレーショナルリサーチ.
泌尿器外科,28((臨増)):723-5 2015
Author:今村哲也


Engineered bone marrow-derived cell sheets restore structure and function of radiation-injured rat urinary bladders.
Tissue Engineering Part A,21(9-10):1600-10 2015
Author:Imamura T, Ogawa T, Minagawa T, Yokoyama H, Nakazawa M, Nishizawa O, Ishizuka O


Pathways involving beta-3 adrenergic receptors modulate cold stress-induced detrusor overactivity in conscious rats.
LUTS,7(1):50-5 2015
Author:Imamura T, shizuka O, Ogawa T, Yamagishi T, Yokoyama H, Minagawa T, Nakazawa M, Nishizawa O


Expression of 5-hydroxytrptamine receptors in human urinary bladders with benign prostatic hyperplasia.
Advance in Therapy,32(Suppl 1):29-37 2015
Author:Imamura T, Ishizuka O, Ogawa T, Minagawa T, Ishikawa M, Hiragata S, Yokoyama H, Nakazawa M, Kurizaki Y, Nishizawa O


Implantation of autologous adipose-derived cells reconstructs functional urethral sphincters in rabbit cryo-injured urethra
Tissue Eng Part A,20(13-14):1971-1979 2014
Author:Sudha GS, Imamura T, Ishizuka O, Zhang L, Yamagishi T, Yokoyama H, Minagawa T, Ogawa T, Kurizaki Y, Kato H, Nishizawa O


Muscarinic receptors mediate cold stress-induced detrusor overactivity in type 2 diabetes mellitus rats
Int J Urol,21(10):1051-1058 2014
Author:Imamura T, Ishizuka O, Ogawa T, Yamagishi T, Yokoyama H, Minagawa T, Nakazawa M, Sudha GS, Nishizawa O


Cold stress induces lower urinary tract symptoms
INTERNATIONAL JOURNAL OF UROLOGY,20(7):661-669 2013(Jul.)
Author:Imamura, T; Ishizuka, O; Nishizawa, O


The Relationship between Alpha1-Adrenergic Receptors and TRPM8 Channels in Detrusor Overactivity Induced by Cold Stress in Ovariectomized Rats
J Urol,189(5):1975-1981 2013
Author:Noguchi W, Ishizuka O, Imamura T, Kurizaki Y, Yamagishi T, Yokoyama H, Zhang L, Gautam S S, Nishizawa O, Karl-Erik Andersson


Relationship between expression of β3-adrenoceptor mRNA in bladder mucosa and urodynamic findings in men with lower urinary tract symptoms
Neurourology and Urodynamics,32(1):88-91 2013
Author:Kurizaki Y, Ishizaka O, Imamura T, Masakuni Ishikawa, Midori Ichino, Teruyuki Ogawa, Nishizawa O, Karl-Erik Andersson


Male lower urinary tract symptoms and α1D-adrenoceptors
International Journal of Urology,20(1):73-78 2013
Author:Ishizuka, O; Imamura, T; Kurizaki, Y; Nishizawa, O; Andersson, KE


A galenical produced from Ba-Wei-Die-Huang-Wan (THC-002) provides resistance to the cold stress-induced detrusor overactivity in conscious rats
Neurourol Urodyn,32(5):486-492 2013
Author:Imamura T, Ishizuka O, Gautam S S, Zhang L, Hosoda T, Noguchi W, Yamagishi T, Yokoyama H, Kurizaki Y, Nishizawa O


Functional roles of Transient Receptor Potential Melastatin 8 (TRPM8) channels in the cold stress-induced detrusor overactivity pathways in conscious rats
Neurourology and Urodynamics,32:500-504 2013
Author:Zhang L, Ishizuka O, Imamura T, Noguchi W, Yamagishi T, Yokoyama H, Gautam S S, Hosoda T, Nishizawa O


Videourodyanamic Examination and Tension-free Vaginal Mesh/Transobturator Tape Surgery
LUTS,4:110-113 2012
Author:Nishizawa O, Ichino M, Ishikawa M, Tanabe T, Suzuki H, Saito T, Imamura T, Ishizuka O


The relationship between toe temperature and lower urinary tract symptoms
LUTS,4:144-149 2012
Author:Inoue H, Ishizuka O, Imamura T, Yamagishi T, Noguchi W, Yokoyama H, Kurizaki Y, Nishizawa O


Cold Stress and Urinary Frequency
LUTS,4:67-74 2012
Author:Osamu Ishizuka, Tetsuya Imamura, Osamu Nishizawa


Autologous Bone Marrow-Derived Cells Regenerate Urethral Sphincters
LUTS,4:87-94 2012
Author:Imamura Tetsuya, Osamu Ishizuka, Osamu Nishizawa


Bone marrow-derived cells implanted into radiation-injured urinary bladders reconstructs functional bladder tissues in rats
Tissue Eng Part A,18:1698-1709 2012
Author:Imamura T, Ishizuka O, Zhang L, Hida S, Gautam S, Kato H, Nishizawa O


A Galenical of Traditional Chinese Herbal Mixture (THC-002) Reduces Expression of Tachykinin Peptides within Urethras of Spontaneously Hypertensive Rats
Neurourology and Urodynamics,31:201-206 2012
Author:Ishikawa M, Imamura T, Ishizuka O, Kurizaki Y, Noguchi W, Zhang L, Nishizawa O


骨髄由来細胞移植による膀胱再生
排尿障害プラクテイス,18(4):338-346 2011
Author:今村哲也,石塚 修,西沢 理


Relation between expression of α1-adrenoceptor mRNAs in bladder mucosa and urodynamic findings in men with lower urinary tract symptoms
Scand J Urol Nephrol,45(1):15-19 2011
Author:Kurizaki Y, Ishizuka O, Imamura T, Ichino M, Ogawa T, Igawa Y, Nishizawa O, Andersson KE


Implantation of autologous bone-marrow-derived cells reconstructs functional urethral sphincters in rabbits.
Tissue Eng Part A 17,17(7-8):1069-1081 2011
Author:Imamura T, Ishizuka O, Kinebuchi Y, Kurizaki Y, Nakayama T, Ishikawa M, Nishizawa O:


Analysis of the pressure-flow study in weak detrusor patients with benign prostatic hypertrophy
LUTS,3:109-112 2011
Author:Tanabe T, Ishizuka O, Ichino M, Ogawa T, Imamura T, Kurizaki Y, Iijima K, Nishizawa O


Implantation of autologous bone marrow-derived cells reconstructs functional urethral sphincters in rabbits.
Tissue Engineering,17:1069-1081 2011
Author:Imamura T, Ishizuka O, Kinebuchi Y, Kurizaki Y, Nakayama T, Ishikawa M, Nishizawa O


最新のトピックス 骨髄由来細胞移植による膀胱再生
信州医学雑誌,58(5):263-265 2010(Oct.)
Author:今村哲也,


骨髄由来細胞移植による膀胱再生
排尿障害プラクティス18,:36-44 2010
Author:今村哲也, 石塚 修, 西沢 理


Stimulation of Skin Menthol Receptors Stimulates Detrusor Activity in Conscious Rats.
Neurourology and Urodynamics,29:506-511 2010
Author:Chen Zhong, Osamu Ishizuka, Tetsuya Imamura, Naoki Aizawa, Yoshiki Kurizaki, Yasuhiko Igawa, Osamu Nishizwa, Andersson Karl-Erik.


Impact of high-consistency area evaluated under hand-operated transrectal compression using a sonographic probe on detection of prostate cancer: clinicopathological analysis
International Journal Urology,17(10):876-880 2010
Author:Tomonori Minagawa, Yasushi Murata, Takeshi Uehara, Tetsuya Imamura, Osamu Ishizuka.


Expression of α1-Adrenergic Receptor Subtypes and Angiotensin II Type 1 Receptors in the Prostate of Spontaneously Hypertensive Rats.
The Shinshu Medical Journal,58:103-114 2010
Author:Tsuyoshi Nakayama, Tetsuya Imamura, Osamu Ishizuka, Osamu Nishizawa.


Rat Bladders Augmented with a Novel Bovine Pericardium-Derived Biomaterial Reconstruct Functional Tissue Structures.
LUTS,,2:76-82 2010
Author:Yuji Mimura, Tetsuya Imamura, Yoshiaki Kinebuchi, Naoki Aizawa, Osamu Ishizuka, Osamu Nishizawa.


Bone Marrow-Derived Cells Implanted into Freeze-njured Urinary Bladders Reconstructs Functional Smooth Muscle Layers.
LUTS,,2:1-10 2010
Author:Tetsuya Imamura, Osamu Ishizuka, Tokunori Yamamoto, Momokazu Gotoh, Osamu Nishizawa.


Differentiation of Smooth Muscle Cells from Human Amniotic Mesenchymal Cells Implanted in The Freeze-injured Mouse Urinary Bladder.
European Urology,58(2):299-306 2010
Author:Tomonori Minagawa, Tetsuya Imamura, Naoki Aizawa, Osamu Ishizuka, Yasuhiko Igawa, Osamu Nishizawa.


CXCR3 Binding Chemokine and TNFSF14 Over Expression in Bladder Urothelium of Patients With Ulcerative Interstitial Cystitis.
The Journal of Urology,183:1206-1212 2010
Author:Teruyuki Ogwa, Toshiki Homma, Yasuhiko Igawa, Satoshi Seki, Osamu Ishizuka, Tetsuya Imamura, Satoshi Akahane, Yukio Homma, Osamu Nishizawa.


Autologous Bone-Marrow-Derived Mesenchymal Stem Cell Transplantation into Injured Rat Urethral Sphincter.
International Journal of Urology,,17:359-368 2010
Author:Yoshiaki Kinebuchi, Naoki Aizawa, Tetsuya Imamura, Osamu Ishizuka, Yasuhiko Igawa, Osamu Nishizawa.


The Microenvironment of Freeze-injured Mouse Urinary Bladders Enables Successful Tissue Engineering.
Tissue Engineering,15(11):3367-3375 2009
Author:Tetsuya Imamura, Tomonori Yamamoto, Osamu Ishizuka, Momokazu Gotoh, Osamu Nishizawa.


Role of α1-Adrenergic Receptors in Detrusor Overactivity Induced by Cold Stress in Conscious Rat.
Neurourology and Urodynamics,,28:251-256 2009
Author:Chen Zhong, Osamu Ishizuka, Tetsuya Imamura, Naoki Aizawa, Yasuhiko Igawa, Osamu Nishizwa, Andersson Karl-Erik.


An Extract (THC-002) of Ba-Wei-Die-Huang-Wan Inhibits Expression of Tachykinins, and P2X3 and TRPV1 Receptors, and Inhibits ATP-Induced Detrusor Overactivity in Spontaneously Hypertensive Rats.
Neurourology and Urodynamics,28:529-534 2009
Author:Tetsuya Imamura, Osamu Ishizuka, Chen Zhong, Teruyuki Ogawa, Tsuyoshi Nakayama, Yoshiki Kurizaki, Tomoaki Tanabe, Osamu Nishizwa, Andersson Karl-Erik.


Expression of Cytochrome P450 and Transcription Factors during In Vitro Differentiation of Mouse Embryonic Stem Cells into Hepatocytes.
Pharmacokinet,23(3):188-195 2008
Author:Kayoko Maezawa, Kenji Miyazato, Tamihide Matsunaga, Yasuyuki Momose, Tetsuya Imamura, Kohei Johkura, Katsunori Sasaki, Shigeru Ohmori.


Direct induced of layerd tissues from mouse embryonic stem cells: potential for differentiation into urinary tract tissue.
Cell Tissue Res,311:605-615 2008
Author:Yoshiaki Kinebuchi, Kohei Johkura, Katsunori Sasaki, Tetsuya Imamura, Yuji Mimura, Osamu Nishizawa.


Gosha-jinki-gan Reduces Transmitter Protein and Sensory Receptors Associated with C Fiber Activation Induced by Acetic Acid in Rat Urinary Bladder.
Neurourology and Urodynamics,27:832-837 2008
Author:Tetsuya Imamura, Osamu Ishizuka, Naoki Aizawa, Chen Zhong, Teruyuki Ogawa, Tsuyoshi Nakayama, Tomoaki Tanabe, Osamu Nishizwa.


Implanted Mouse Bone Marrow-Derived Cells Reconstruct Layered Smooth Muscle Structures in Injured Urinary Bladders.
Cell Transplantation,17:267-278 2008
Author:Tetsuya Imamura, Yoshiaki Kinebuchi, Osamu Ishizuka, Satoshi Seki, Yasuhiko Igawa, Osamu Nishizawa.


Cold Environment Stress Induces Detrusor Overactivity via Resiniferatoxin-Sensitive Nerves in Conscious Rats.
Neurourology and Urodynamics,27:348-352 2008
Author:Tetsuya Imamura, Osamu Ishizuka, Naoki Aizawa, Chen Zhong, Teruyuki Ogawa, Tsuyoshi Nakayama, Tomoaki Tanabe, Osamu Nishizwa.


Transplantation of Preserved Human Amniotic Membrane for Bladder Augmentation in Rats.
Tissue Engineering,13(3):513-524 2007
Author:Kazuhiko Iijima, Yasuhiko Igawa, Tetsuya Imamura, Tetsuzi Moriizumi, Toshio Nikaido, Ikuo Konishi, Osamu Nishizawa.


Three-Dimensional Culture Systems for Differentiation of Mice Embryonic Stem Cells into Hepatocyte-Like Cells.
Journal of Organ Disfunction,4(1):57-64 2007
Author:Testuya Imamura, Yoshiaki Kinebuchi, Osamu Ishizuka, Satoshi Seki, Yasuhiko Igawa, Osamu Nishizawa.


障害を受けたマウス膀胱平滑筋に対する骨髄細胞筋内移植による平滑筋層再構築の試み
日本泌尿器科学会雑誌,97(2):275 2006
Author:今村哲也, 杵渕芳明, 石塚 修, 井上博夫, 三村裕司, 相澤直樹, 西沢 理


Effects of Gosyazinkigan (Niu-Che-Sen-Qi-Wan) for Resiniferatoxin-Sensitive Afferent on Detrusor Overactivity Induced by Acetic Acid in Conscious Rats.
The American Journal of Chinese Medicine,,34(2):285-293 2006
Author:Xiaoyang Zhang, Osamu Ishizuka, Tomoaki Tanabe, Tsuyoshi Nakayama, Tetsuya Imamura, Osamu Nishizawa.


Embryonic stem cell-derived embryoid bodies in three-dimensional culture system from hepatocyte-like cells in vitro and in vivo.
Tissue Engineering,,10(11/12):1716-1724 2004
Author:Tetsuya Imamura, Li Cui, Ruifeng Teng, Kohei Johkura, Yasumitsu Okouchi, Kazuhiko Asanuma, Naoko Ogiwara, Katsunori Sasaki.


A simple method for forming embryoid stem cells.
Journal of Bioscience and Bioengineering,,96(4):409-411 2003
Author:Hiroshi Kurosawa, Tetsuya Imamura, Mikiko Koike, Yoshifumi Amano.


講演・口頭発表等
Transient Receptor Potential Ankyrin 1 (TRPA1) Channels Mediate Cold Stress Induced Detrusor Overactivity in Rats.
35th CONGRESS OF The SOCIÉTÉ INTERNATINALE D’UROLOGIE 2015(Oct. 15)
Presenter:Imamura T, Ogawa T, Minagawa T, Nagai T, Yokoyama H, Nakazawa M, Ishizuka O


Combination of β3-Adrenergic Receptor agonist and Muscarinic Receptor antagonist Inhibits Cold Stress-induced Detrusor Overactivity of Spontaneously Hypertensive Rats.
The 10th Pan-Pacific Continence Society Meeting 2015(Sep. 07)
Presenter:Imamura T, Ogawa T, Nagai T, Minagawa T, Nakazawa M, Suzuki T, Ueno M, Saito T,Yokoyama H, Nishizawa O, Ishizuka O


冷えストレスによる下部尿路障害に対する漢方薬治療の基礎研究.
第32回泌尿器科漢方研究会学術集会 2015(Jun. 20)
Presenter:今村哲也, 皆川倫範, 小川輝之, 中沢昌樹, 西澤 理, 石塚 修


下部尿路再生をめざした新規細胞凝集体(スフェロイド)シート作製の試み.
第103回日本泌尿器科学会総会 2015(Apr. 18)
Presenter:今村哲也, 小川輝之, 皆川倫範, 永井 崇, 横山 仁, 石川雅邦, 平形志朗, 道面尚久, 中沢昌樹, 石塚 修


ラット放射線照射傷害膀胱モデルを用いた骨髄由来細胞移植による膀胱再生の試み
第4回排尿障害モデル動物研究会 2011(Nov. 25)
Presenter:今村哲也,石塚 修,栗崎功己,野口 渉,張  雷,西沢 理


Implantation of autologous bone marrow-derived cells recovers urethral sphincter in rabbits
The 41th Annual Meeting of the International Continence Society (2011/8/29-9/2) 2011(Aug. 29)
Presenter:Imamura T, Ishizuka O, Kurizaki Y, Ishikawa M, Noguchi A, Zhang L, Ichino M, Kato H, Nishizawa O


放射線照射によるラット膀胱機能障害モデルを用いた骨髄細胞移植による膀胱再生の試み
第8回泌尿器科再建再生研究会 2011(Jun. 11)
Presenter:今村哲也,石塚 修,栗崎功己,石川雅邦,野口 渉,張 雷,西沢 理:


塩分負荷による自然発症高血圧ラット膀胱組織でのα1交感神経受容体発現変化についての検討
第99回日本泌尿器科学会総会 2011(Apr. 23)
Presenter:今村哲也,石塚 修,栗崎功己,石川雅邦,野口 渉,張 雷,西沢 理


ウサギ自己骨髄由来細胞移植による機能的な尿道組織再生への試み
第10回日本再生医療学会総会 2011(Mar. 01)
Presenter:今村哲也,石塚 修,栗崎功己,石川雅邦,野口 渉,張 雷,西沢 理

研究費
科学研究費補助金(研究代表者)
「ウサギ放射線照射傷害膀胱に対する自己骨髄由来細胞による機能的な膀胱再生への試み」 , 平成19年度 文部科学省科学研究費補助金 若手研究 (B)
「放射線照射傷害膀胱に対する自己骨髄由来細胞による機能的な膀胱再生の検討」 , 平成20年度 文部科学省科学研究費補助金 若手研究 (B)