山条 秀樹 (サンジョウ ヒデキ)
学術研究院（医学系）
医学部 医学科 免疫制御学
准教授
研究者情報
研究キーワード
- 自然免疫応答, 獲得免疫応答, 粘膜免疫制御機構, 炎症反応, 免疫細胞の発生・分化・生存・細胞死, 単球・マクロファージ, サイトカインによる生体防御, 免疫関連受容体の細胞内シグナル伝達
メールアドレス
- hsanjo★shinshu-u.ac.jp
経歴
研究活動情報
論文
- White Blood Cell Counting Device for Dairy Cattle Using Microchannel Incorporating Light Scattering
Yamaguchi, Masaki; Nakamura, Tsuyoshi; Sanjo, Hideki;
Sensors and Materials, 35(4), 1281-1292, 2023年
- Interferon regulatory factor-2 is required for the establishment of the gut intraepithelial T-cell compartment
Tokumaru, Shigeo; Yamamoto, Yuta; Yoshizawa, Kazuki; Soejima, Yuji; Sanjo, Hideki; Taki, Shinsuke;
INTERNATIONAL IMMUNOLOGY, 35(5), 231-241, 2023年 - Presence of periodontitis may synergistically contribute to cancer progression via Treg and IL-6
Kajihara, Ryo; Sakai, Hironori; Han, Yibing; Amari, Kei; Kawamoto, Makiko; Hakoyama, Yusuke; Nagashio, Sachiho; Yamada, Shin-ichi; Sanjo, Hideki; Kurita, Hiroshi;
SCIENTIFIC REPORTS, 12(1), 11584, 2022年 - TAK1 Limits Death Receptor Fas-Induced Proinflammatory Cell Death in Macrophages
Maeda, Kengo; Nakayama, Jun; Taki, Shinsuke; Sanjo, Hideki;
JOURNAL OF IMMUNOLOGY, 209(6), 1173-1179, 2022年 - Circulating T cells and resident non-T cells restrict type 2 innate lymphoid cell expansion in the small intestine
Yamamoto, Yuta; Yoshizawa, Kazuki; Takamoto, Masaya; Soejima, Yuji; Sanjo, Hideki; Taki, Shinsuke;
Biochemical and biophysical research communications, 618, 93-99, 2022年 - Adrenomedullin Ameliorates Pulmonary Fibrosis by Regulating TGF-beta-Smads Signaling and Myofibroblast Differentiation
Wei, Yangxuan; Tanaka, Megumu; Sakurai, Takayuki; Kamiyoshi, Akiko; Ichikawa-Shindo, Yuka; Kawate, Hisaka; Cui, Nanqi; Kakihara, Shinji; Zhao, Yunlu; Aruga, Kohsuke; Sanjo, Hideki; Shindo, Takayuki;
Endocrinology, 162(8), 2021年08月
- Extracellular mRNA transported to the nucleus exerts translation-independent function
Tomita, Takeshi; Kato, Masayoshi; Mishima, Taishi; Matsunaga, Yuta; Sanjo, Hideki; Ito, Ken-ichi; Minagawa, Kentaro; Matsui, Toshimitsu; Oikawa, Hiroyuki; Takahashi, Satoshi; Takao, Toshifumi; Iwai, Noriki; Mino, Takashi; Takeuchi, Osamu; Maru, Yoshiro; Hiratsuka, Sachie;
NATURE COMMUNICATIONS, 12(1), 2021年 - Staphylococcal superantigen-like 12 activates murine bone marrow derived mast cells.
Kobayashi M, Kitano T, Nishiyama S, Sanjo H, Onozaki K, Taki S, Itoh S, Hida S.
Biochem Biophys Res Commun., 2019年 - Water intake increases mesenteric lymph flow and the total flux of albumin, long-chain fatty acids, and IL-22 in rats: New concept of absorption in jejunum.
Nagashio S, Ajima K, Maejima D, Sanjo H, Kajihara R, Hayashi M, Watanabe-Asaka T, Kaidoh M, Yokoyama Y, Taki S, Kawai Y, Ohhashi T.
Am J Physiol Gastrointest Liver Physiol., 2019年 - Generation of a common innate lymphoid cell progenitor requires interferon regulatory factor 2.
Okubo Y, Tokumaru S, Yamamoto Y, Miyagawa SI, Sanjo H, Taki S.
Int Immunol., 2019年 - Cutting Edge: TAK1 Safeguards Macrophages against Proinflammatory Cell Death
Sanjo, Hideki; Nakayama, Jun; Yoshizawa, Takahiro; Fehling, Hans Joerg; Akira, Shizuo; Taki, Shinsuke;
JOURNAL OF IMMUNOLOGY, 203(4), 783-788, 2019年 - Loss of TAK1 leads to TLR-driven macrophage cell death and inflammation that occur by a TNF-independent mechanism
Sanjo, Hideki; Taki, Shinsuke;
CYTOKINE, 100, 78-79, 2017年12月 - Conditional Deletion of TAK1 in T Cells Reveals a Pivotal Role of TCRalphabeta+ Intraepithelial Lymphocytes in Preventing Lymphopenia-Associated Colitis.
Sanjo H, Tokumaru S, Akira S, Taki S.
PLOS ONE, 2015年 - Phosphoproteomic analysis of kinase-deficient mice reveals multiple TAK1 targets in osteoclast differentiation.
Sumiya E, Negishi-Koga T, Nagai Y, Suematsu A, Suda T, Shinohara M, Sato K, Sanjo H, Akira S, Takayanagi H.
Biochem Biophys Res Commun., 2015年 - Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-kappaB activation.
Shinohara H, Behar M, Inoue K, Hiroshima M, Yasuda T, Nagashima T, Kimura S, Sanjo H, Maeda S, Yumoto N, Ki S, Akira S, Sako Y, Hoffmann A, Kurosaki T, Okada-Hatakeyama M.
science, 2014年 - Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs.
Ori D, Kato H, Sanjo H, Tartey S, Mino T, Akira S, Takeuchi O.
J Immunol., 2013年 - Differential requirements for IRF-2 in generation of CD1d-independent T cells bearing NK cell receptors.
Notake T, Horisawa S, Sanjo H, Miyagawa S, Hida S, Taki S.
J Immunol., 2012年 - Polymorphic variants of LIGHT (TNF superfamily-14) alter receptor avidity and bioavailability.
Cheung TC, Coppieters K, Sanjo H, Oborne LM, Norris PS, Coddington A, Granger SW, Elewaut D, Ware CF.
J Immunol., 2010年 - Allosteric regulation of the ubiquitin:NIK and ubiquitin:TRAF3 E3 ligases by the lymphotoxin-beta receptor.
Sanjo H, Zajonc DM, Braden R, Norris PS, Ware CF.
J Biol Chem, 2010年 - T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment.
Cheung TC, Oborne LM, Steinberg MW, Macauley MG, Fukuyama S, Sanjo H, D'Souza C, Norris PS, Pfeffer K, Murphy KM, Kronenberg M, Spear PG, Ware CF.
J Immunol., 2009年 - Unconventional ligand activation of herpesvirus entry mediator signals cell survival.
Cheung TC, Steinberg MW, Oborne LM, Macauley MG, Fukuyama S, Sanjo H, D'Souza C, Norris PS, Pfeffer K, Murphy KM, Kronenberg M, Spear PG, Ware CF.
Proc Natl Acad Sci U S A., 2009年 - Regulation of immunity through the LT beta receptor and HVEM-BTLA circuit
Ware, Carl F.; Cheung, Tim; DeTrez, Carl; Schneider, Kirsten; Sedy, John; Jacquin, Claire; Fukuyama, Satoshi; Sanjo, Hideki; Greenberg, Brian;
CYTOKINE, 43(3), 236-236, 2008年09月 - Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion.
Yasuda T, Sanjo H, Pages G, Kawano Y, Karasuyama H, Pouyssegur J, Ogata M, Kurosaki T.
Immunity, 2008年 - Extracellular signal-regulated protein kinase 2 is required for efficient generation of B cells bearing antigen-specific immunoglobulin G.
Sanjo H, Hikida M, Aiba Y, Mori Y, Hatano N, Ogata M, Kurosaki T.
Mol Cell Biol., 2007年 - TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells
Sato, Shintaro; Sanjo, Hideki; Tsujimura, Tohru; Ninomiya-Tsuji, Jun; Yamamoto, Masahiro; Kawai, Taro; Takeuchi, Osamu; Akira, Shizuo;
INTERNATIONAL IMMUNOLOGY, 18(10), 1405-1411, 2006年10月 - Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling
Yamamoto, Masahiro; Okamoto, Toru; Takeda, Kiyoshi; Sato, Shintaro; Sanjo, Hideki; Uematsu, Satoshi; Saitoh, Tatsuya; Yamamoto, Naoki; Sakurai, Hiroaki; Ishii, Ken J.; Yamaoka, Shoji; Kawai, Taro; Matsuura, Yoshiharu; Takeuchi, Osamu; Akira, Shizuo;
NATURE IMMUNOLOGY, 7(9), 962-970, 2006年09月 - BANK negatively regulates Akt activation and subsequent B cell responses.
Aiba Y, Yamazaki T, Okada T, Gotoh K, Sanjo H, Ogata M, Kurosaki T.
Immunity, 2006年 - TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB.
Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, Ninomiya-Tsuji J.
J Biol Chem, 2006年 - Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway.
Zhu P, Baek SH, Bourk EM, Ohgi KA, Garcia-Bassets I, Sanjo H, Akira S, Kotol PF, Glass CK, Rosenfeld MG, Rose DW
Cell, 2006年 - TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis
Omori, Emily; Matsumoto, Kunihiro; Sanjo, Hideki; Sato, Shintaro; Akira, Shizuo; Smart, Robert C.; Ninomiya-Tsuji, Jun;
JOURNAL OF BIOLOGICAL CHEMISTRY, 281(28), 19610-19617, 2006年 - TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway.
Kishida S, Sanjo H, Akira S, Matsumoto K, Ninomiya-Tsuji J.
Genes Cells, 2005年 - Essential function for the kinase TAK1 in innate and adaptive immune responses.
Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Matsumoto K, Takeuchi O, Akira S.
Nat Immunol., 2005年 - PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1.
Shinohara H, Yasuda T, Aiba Y, Sanjo H, Hamadate M, Watarai H, Sakurai H, Kurosaki T.
J Exp Med., 2005年 - The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.
Hemmi H, Takeuchi O, Sato S, Yamamoto M, Kaisho T, Sanjo H, Kawai T, Hoshino K, Takeda K, Akira S.
J Exp Med., 2004年 - TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling.
Sanjo H, Takeda K, Tsujimura T, Ninomiya-Tsuji J, Matsumoto K, Akira S.
Mol Cell Biol, 2003年 - Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S
science, 2003年 - Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.
Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S.
Nat Immunol., 2002年 - Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.
Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S.
Nature, 2002年 - 特集 モチーフ･ドメインリスト 9.その他 DEATHドメイン
山条 秀樹;審良 静男
生体の科学, 52(5), 521-522, 2001年10月15日 - A Toll-like receptor recognizes bacterial DNA.
Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S.
Nature, 2000年 - Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product.
Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, Akira S.
J Immunol., 1999年 - Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains.
Kawai T, Sanjo H, Akira S.
GENE, 1999年 - A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages.
Matsumoto M, Tanaka T, Kaisho T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Akira S.
J Immunol, 1999年 - Limb and skin abnormalities in mice lacking IKKalpha.
Takeda K, Takeuchi O, Tsujimura T, Itami S, Adachi O, Kawai T, Sanjo H, Yoshikawa K, Terada N, Akira S.
science, 1999年 - Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S.
Immunity, 1999年 - A novel member of an expanding toll-like receptor family.
Takeuchi O, Kawai T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S.
GENE, 1999年 - Ig receptor binding protein 1 (alpha4) is associated with a rapamycin-sensitive signal transduction in lymphocytes through direct binding to the catalytic subunit of protein phosphatase 2A.
Inui S, Sanjo H, Maeda K, Yamamoto H, Miyamoto E, Sakaguchi N.
BLOOD, 1998年 - ZIP kinase, a novel serine/threonine kinase which mediates apoptosis.
Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S.
Mol Cell Biol., 1998年 - The gene structure and promoter analysis of mouse lymphocyte signal transduction molecule alpha 4 that is related to the yeast TAP42 involved in a rapamycin-sensitive pathway
Maeda K, Inui S, Sanjo H, Sakaguchi N.
GENE, 1998年 - DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis.
Sanjo H, Kawai T, Akira S.
J Biol Chem., 1998年
担当経験のある科目_授業
共同研究・競争的資金等の研究課題
- TNFシグナル関連分子群に着目したマクロファージの運命決定制御機構の解明
科学研究費補助金, 基盤研究(C)（一般）
2021年 - 2023年 - 家族性地中海熱（FMF）インフラマソームシグナル伝達異常をゲノム創薬で解決する開発研究
受託事業, 日本医療研究開発機構(AMED)
2019年04月01日 - TNFシグナル関連分子群に着目したマクロファージの発生分化制御機構の解明
科学研究費補助金, 日本学術振興会, 基盤研究(C)
2016年 - 2018年 - 好塩基球のサイトカイン産生と２型免疫応答発動に関与するシグナル伝達経路の制御機構
科学研究費補助金, 日本学術振興会, 若手研究（B）
2011年 - 2012年 - 細胞内シグナル伝達分子に着目した免疫制御機構
- 単球・マクロファージの分化制御機構
- 単球・マクロファージに着目した炎症応答制御機構
- 炎症の収束と組織修復
