書籍等出版物 Free-Energy Landscape of Intrinsically Disordered Proteins Investigated by All-Atom Multicanonical Molecular Dynamics, Protein Conformational Dynamics: Advances in Experimental Medicine and Biology 805 , 331-351 Springer 2013(Dec. 16) Author:Junichi Higo, Koji Umezawa
論文 Identification of a novel osteogenetic oligodeoxynucleotide (osteoDN) that promotes osteoblast differentiation in a TLR9-independent manner. Nanomaterials,12(10):1680 2022(May 14) Author:Nihashi Y, Miyoshi M, Umezawa K, Shimosato T, Takaya T.
Myogenetic oligodeoxynucleotide complexed with berberine promotes differentiation of chicken myoblasts. Animal Science Journal,92(1):e13597 2021(Jul. 25) Author:Nihashi Y, Shinji S, Umezawa K, Shimosato T, Ono T, Kagami H, Takaya T
Identification of the Myogenetic Oligodeoxynucleotides (myoDNs) That Promote Differentiation of Skeletal Muscle Myoblasts by Targeting Nucleolin Frontiers in Cell and Developmental Biology,8:616706 2021(Jan.) Author:Shinji S, Umezawa K, Nihashi Y, Nakamura S, Shimosato T, Takaya T.
Hyperstable De Novo Protein with a Dimeric Bisecting Topology ACS SYNTHETIC BIOLOGY,9(2):254-259 2020(Jan. 17) Author:Kimura N., Mochizuki K., Umezawa K., Hecht MH., Arai R.
Berberine and palmatine inhibit the growth of human rhabdomyosarcoma cells. Biosci Biotechnol Biochem,84(1):63-75 2020 Author:Shinji, S; Nakamura, S; Nihashi, Y; Umezawa, K; Takaya, T
Distinct cell proliferation, myogenic differentiation, and gene expression in skeletal muscle myoblasts of layer and broiler chickens Scientific Reports,9:16527 2019(Nov. 11) Author:Nihashi Y, Umezawa K, Shinji S, Hamaguchi Y, Kobayashi H, Kono T, Ono T, Kagami H, Takaya T
Synthesis of epigallocatechin trimer, (epigallocatechin)2-epicatechin, and (epigallocatechin)2-catechin via a Lewis acid mediated one-pot condensation and their antitumor activities in prostate cancer cells. Tetrahedron,74(27):3534-3542 2018(Jul. 05) Author:Ichikawa M, Yamamoto S, Ishihara C, Nonobe S, Hattori Y, Umezawa K, Fujii H, Makabe H
Structural and dynamical characteristics of tropomyosin epitopes as the major allergens in shrimp. Biochemical and Biophysical Research Communications,498(1) 2018(Mar. 25) Author:Ozawa H, Umezawa K, Takano M, Ishizaki S, Watabe S, Ochiai Y
Epicatechin oligomers longer than trimers have anti-cancer activities, but not the catechin counterparts Scientific Reports,7(1):7791 2017(Aug. 10) Author:Takanashi K, Suda M, Matsumoto K, Ishihara C, Toda K, Kawaguchi K, Senga S, Kobayashi N, Ichikawa M, Katoh M, Hattori Y, Kawahara S, Umezawa K, Fujii H, and Makabe H
Over-Destabilization of Protein-Protein Interaction in Generalized Born Model and Utility of Energy Density Integration Cutoff Journal of Physical Chemistry B,121:4669-4677 2017(Apr. 20) Author:Mizuhara Y, Parkin D, Umezawa K, Ohnuki J, Takano M
Intrinsic disorder accelerates dissociation rather than association Proteins: Structure, Function, and Bioinformatics,-(-) 2016(May 18) Author:Koji Umezawa, Jun Ohnuki, Junichi Higo, Mitsunori Takano
Enhanced sampling simulations to construct free-energy landscape of protein–partner substrate interaction Biophysical Reviews,8(1):45-62 2016(Jan. 11) Author:Jinzen Ikebe, Koji Umezawa, Junichi Higo
virtual-system coupled multicanonical molecular dynamics simulation: Principles and applications to free-energy landscape of protein–protein interaction with an all-atom model in explicit solvent The Journal of Chemical Physics,138:184106 2013(May 10) Author:Junichi Higo, Koji Umezawa, Haruki Nakamura
Conformational ensembles of an intrinsically disordered protein pKID with and without a KIX domain in explicit solvent investigated by all-atom multicanonical molecular dynamics Biomolecules,2(1):104-121 2012(Feb. 22) Author:Koji Umezawa, Jinzen Ikebe, Mitsunori Takano, Haruki Nakamura, Junichi Higo
Theory for trivial trajectory parallelization of multicanonical molecular dynamics and application to a polypeptide in water Journal of Computational Chemistry,32(7):1286-1297 2010(Dec. 15) Author:Jinzen Ikebe, Koji Umezawa, Narutoshi Kamiya, Takanori Sugihara, Yasushige Yonezawa, Yu Takano, Haruki Nakamura, Junichi Higo
Solvent flow patterns fluctuating largely around a protein and correlation with solvent density fluctuations: A molecular dynamics study The Journal of Chemical Physics,132:155103 2010(Apr. 16) Author:Koji Umezawa, Ryota Morikawa, Haruki Nakamura, Junichi Higo
Conformational requirement on peptides to exert laminin's activities and search for protein segments with laminin's activities Biopolymers,92(2):124-131 2009(Jan. 29) Author:Koji Umezawa, Jinzen Ikebe, Motoyoshi Nomizu, Haruki Nakamura, Junichi Higo
Solvent Site-Dipole Field Accompanying Protein-Ligand Approach Process Chem-Bio Informatics Journal,8(1):14-24 2008(Apr. 29) Author:Norikazu Takano, Koji Umezawa, et al.
Structure dependency of a 24-residue peptide humanin on solvent and preferential solvation by trifluoroethanol studied by multicanonical sampling Chemical Physics Letters,455(4-6):293-296 2008(Apr. 10) Author:Ryosuke Yagisawa, Narutoshi Kamiya, Jinzen Ikebe, Koji Umezawa, Junichi Higo
Collective solvent flows around a protein investigated by molecular dynamics simulation The Journal of Chemical Physics,127(4):045101 2007(Jul. 26) Author:Koji Umezawa, Junichi Higo, Sakurako Shimotakahara, Heisaburo Shindo
Cyclic Peptide Analysis of the Biologically Active Loop Region in the Laminin α3 Chain LG4 Module Demonstrates the Importance of Peptide Conformation on Biological Activity Biochemistry,46(7):1952-1960 2007(Jan. 30) Author:Kozue Kato-Takagaki, Nobuharu Suzuki, Fumiharu Yokoyama, Shu Takaki, Koji Umezawa, Junichi Higo, Marumi Mochizuki, Yamato Kikkawa, Shinya Oishi, Atsushi Utani, Motoyoshi Nomizu
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