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笹土 隆雄  ササド タカオ

教員組織電話番号0263-37-2033 (ext: 2053)
教育組織学術研究・産学官連携推進機構 リサーチアドミニストレーション室FAX番号
職名准教授(URA)メールアドレスsasado@shinshu-u.ac.jp
住所〒390-8621 長野県松本市旭3-1-1ホームページURL

プロフィール

研究分野
発生遺伝学
生物教育学
所属学会
所属学会
リサーチ・アドミニストレーター協議会
日本分子生物学会
日本生物教育学会
学歴
出身大学院
1999 , 名古屋大学大学院 理学研究科
1995 , 京都大学大学院 博士課程前期 人間・環境学研究科

出身学校・専攻等(大学院を除く)
1993 , 広島大学 総合科学部 総合科学科

取得学位
博士(理学) , 名古屋大学
研究職歴等
研究職歴
2008-2016 , 基礎生物学研究所 進化多様性生物学領域 バイオリソース研究室・研究員
2007-2008 , 長浜バイオ大学 バイオサイエンス学部 環境生命科学コース・助手
2003-2007 , 科学技術振興機構 戦略的創造研究推進事業 発展研究(SORST)近藤研究チーム・研究員
2000-2003 , 科学技術振興機構 戦略的創造研究推進事業(ERATO)近藤誘導分化プロジェクト・技術員-研究員
1999-2000 , ドイツ連邦共和国 フライブルグ大学 第一生物学研究所 発生生物学部門 (Institute für Biologie I, Albert-Ludwigs-Universität Freiburg, Germany)・研究員
1998-1995 , 日本学術振興会・特別奨励研究員 (DC1)

研究職歴以外の職歴
2020-2021 , 日本医療研究開発機構 (AMED) ゲノム・データ基盤事業部 ゲノム医療基盤研究開発課・主幹
2016-2020 , 日本医療研究開発機構 (AMED) 基盤研究事業部 バイオバンク課・主幹

研究活動業績

研究業績(著書・
発表論文等)
論文
Production of the medaka derived from vitrified whole testes by germ cell transplantation
SCIENTIFIC REPORTS,7 2017
Author:Seki, Shinsuke; Kusano, Kazunari; Lee, Seungki; Iwasaki, Yoshiko; Yagisawa, Masaru; Ishida, Mariko; Hiratsuka, Tadashi; Sasado, Takao; Naruse, Kiyoshi; Yoshizaki, Goro;


Mutation in cpsf6/CFIm68 (Cleavage and Polyadenylation Specificity Factor Subunit 6) causes short 3 ' UTRs and disturbs gene expression in developing embryos, as revealed by an analysis of primordial germ cell migration using the medaka mutant naruto
PLOS ONE,12(3) 2017
Author:Sasado, Takao; Kondoh, Hisato; Furutani-Seiki, Makoto; Naruse, Kiyoshi;


Early life exposure to a rodent carcinogen propiconazole fungicide induces oxidative stress and hepatocarcinogenesis in medaka fish
AQUATIC TOXICOLOGY,170:52-61 2016(Jan.)
Author:Tu, Tzu-Yi; Hong, Chwan-Yang; Sasado, Takao; Kashiwada, Shosaku; Chen, Pei-Jen;
Keywords:Propiconazole; Medaka (Oryzias latipes); Oxidative stress; p53; Carcinogenesis;


Genetic variation of Oryzias fishes and their applications for development of new bioresources
GENES & GENETIC SYSTEMS,86(6):382-382 2011(Dec.)
Author:Naruse, Kiyoshi; Takehana, Yusuke; Sasado, Takao; Sakaizumi, Mitsuru;


The National BioResource Project Medaka (NBRP Medaka): An Integrated Bioresource for Biological and Biomedical Sciences
EXPERIMENTAL ANIMALS,59(1):13-23 2010(Jan.)
Author:Sasado, Takao; Tanaka, Minoru; Kobayashi, Kayo; Sato, Tadashi; Sakaizumi, Mitsuru; Naruse, Kiyoshi;
Keywords:cDNA/BAC/fosmid clones; inbred line; mutants; NBRP Medaka; wild stock;


Distinct contributions of CXCR4b and CXCR7/RDC1 receptor systems in regulation of PGC migration revealed by medaka mutants kazura and yanagi
DEVELOPMENTAL BIOLOGY,320(2):328-339 2008
Author:Sasado, Takao; Yasuoka, Akihito; Abe, Keiko; Mitani, Hiroshi; Furutani-Seiki, Makoto; Tanaka, Minoru; Kondoh, Hisato;
Keywords:primordial germ cells; cell migration; cxcr7/rdc1; cxcr4; yanagi mutant; kazura mutant; medaka; lateral line;


Radiation hybrid maps of Medaka chromosomes LG 12, 17, and 22
DNA RESEARCH,14(3):135-140 2007
Author:Su, Feng; Osada, Yumi; Ekker, Marc; Chevrette, Mario; Shimizu, Atsushi; Asakawa, Shuichi; Shiohama, Aiko; Sasaki, Takashi; Shimizu, Nobuyoshi; Yamanaka, Toshiyuki; Sasado, Takao; Mitani, Hiroshi; Geisler, Robert; Kondoh, Hisato; Furutani-Seiki, Makoto;
Keywords:Medaka; radiation hybrid mapping; genetic mapping; BAC;


Generation of medaka gene knockout models by target-selected mutagenesis
GENOME BIOLOGY,7(12) 2006
Author:Taniguchi, Yoshihito; Takeda, Shunichi; Furutani-Seiki, Makoto; Kamei, Yasuhiro; Todo, Takeshi; Sasado, Takao; Deguchi, Tomonori; Kondoh, Hisato; Mudde, Josine; Yamazoe, Mitsuyoshi; Hidaka, Masayuki; Mitani, Hiroshi; Toyoda, Atsushi; Sakaki, Yoshiyuki; Plasterk, Ronald H. A.; Cuppen, Edwin;


Mutations affecting somite formation in the Medaka (Oryzias latipes)
MECHANISMS OF DEVELOPMENT,121(7-8):659-671 2004(Jul.)
Author:Elmasri, H; Winkler, C; Liedtke, D; Sasado, T; Morinaga, C; Suwa, H; Niwa, K; Henrich, T; Hirose, Y; Yasuoka, A; Yoda, H; Watanabe, T; Deguchi, T; Iwanami, N; Kunimatsu, S; Osakada, M; Loosli, F; Quiring, R; Carl, M; Grabher, C; Winkler, S; Del Bene, F; Wittbrodt, J; Abe, K; Takahama, Y; Takahashi, K; Katada, T; Nishina, H; Kondoh, H; Furutani-Seiki, M;
Keywords:Oryzias latipes; somites; segmentation clock; oscillator; Delta/Notch;


Identification of radiation-sensitive mutants in the Medaka, Oryzias latipes
MECHANISMS OF DEVELOPMENT,121(7-8):895-902 2004(Jul.)
Author:Aizawa, K; Mitani, H; Kogure, N; Shimada, A; Hirose, Y; Sasado, T; Morinaga, C; Yasuoka, A; Yoda, H; Watanabe, T; Iwanami, N; Kunimatsu, S; Osakada, M; Suwa, H; Niwa, K; Deguchi, T; Hennrich, T; Todo, T; Shima, A; Kondoh, H; Furutani-Seiki, M;
Keywords:medaka; Oryzias latipes; development; mutagenesis; radiation; ric; apoptosis; repair; malformation; double strand break;


Genetic dissection of the formation of the forebrain in Medaka, Oryzias latipes
MECHANISMS OF DEVELOPMENT,121(7-8):673-685 2004(Jul.)
Author:Kitagawa, D; Watanabe, T; Saito, K; Asaka, S; Sasado, T; Morinaga, C; Suwa, H; Niwa, K; Yasuoka, A; Deguchi, T; Yoda, H; Hirose, Y; Henrich, T; Iwanami, N; Kunimatsu, S; Osakada, M; Winkler, C; Elmasri, H; Wittbrodt, J; Loosli, F; Quiring, R; Carl, M; Grabher, C; Winkler, S; Del Bene, F; Momoi, A; Katada, T; Nishina, H; Kondoh, H; Furutani-Seiki, M;
Keywords:forebrain; telencephalon; diencephalon; mutants; medaka; mutagenesis screen;


Mutations affecting the formation of posterior lateral line system in Medaka, Oryzias latipes
MECHANISMS OF DEVELOPMENT,121(7-8):729-738 2004(Jul.)
Author:Yasuoka, A; Hirose, Y; Yoda, H; Aihara, Y; Suwa, H; Niwa, K; Sasado, T; Morinaga, C; Deguchi, T; Henrich, T; Iwanami, N; Kunimatsu, S; Abe, K; Kondoh, H; Furutani-Seiki, M;
Keywords:Medaka; mutant; posterior lateral line; neuromast; SDF1; CXCR4; primordial germ cell;


Mutations affecting retina development in Medaka
MECHANISMS OF DEVELOPMENT,121(7-8):703-714 2004(Jul.)
Author:Loosli, F; Del Bene, F; Quiring, R; Rembold, M; Martinez-Morales, JR; Carl, M; Grabher, C; Iquel, C; Krone, A; Wittbrodt, B; Winkler, S; Sasado, T; Morinaga, C; Suwa, H; Niwa, K; Henrich, T; Deguchi, T; Hirose, Y; Iwanami, N; Kunimatsu, S; Osakada, M; Watanabe, T; Yasuoka, A; Yoda, H; Winkler, C; Elmasri, H; Kondoh, H; Furutani-Seiki, M; Wittbrodt, J;
Keywords:Medaka; teleost; mutagenesis; large scale; eye; retina;


Mutations affecting retinotectal axonal pathfinding in Medaka, Oryzias latipes
MECHANISMS OF DEVELOPMENT,121(7-8):715-728 2004(Jul.)
Author:Yoda, H; Hirose, Y; Yasuoka, A; Sasado, T; Morinaga, C; Deguchi, T; Henrich, T; Iwanami, N; Watanabe, T; Osakada, M; Kunimatsu, S; Wittbrodt, J; Suwa, H; Niwa, K; Okamoto, Y; Yamanaka, T; Kondoh, H; Furutani-Seiki, M;
Keywords:retinotectal axonal projection; axonal pathfinding; mutagenesis screen; guidance cues; Medaka;


Mutations affecting thymus organogenesis in Medaka, Oryzias latipes
MECHANISMS OF DEVELOPMENT,121(7-8):779-789 2004(Jul.)
Author:Iwanami, N; Takahama, Y; Kunimatsu, S; Li, H; Takei, R; Ishikura, Y; Suwa, H; Niwa, K; Sasado, T; Morinaga, C; Yasuoka, A; Deguchi, T; Hirose, Y; Yoda, H; Henrich, T; Ohara, O; Kondoh, H; Furutani-Seiki, M;
Keywords:thymus; organogenesis; pharyngeal arch; Medaka; ethylnitrosourea-induced mutagenesis; immune systern; T lymphocyte;


Mutations affecting early distribution of primordial germ cells in Medaka (Oryzias latipes) embryo
MECHANISMS OF DEVELOPMENT,121(7-8):817-828 2004(Jul.)
Author:Sasado, T; Morinaga, C; Niwa, K; Shinomiya, A; Yasuoka, A; Suwa, H; Hirose, Y; Yoda, H; Henrich, T; Deguchi, T; Iwanami, N; Watanabe, T; Kunimatsu, S; Osakada, M; Okamoto, Y; Kota, Y; Yamanaka, T; Tanaka, M; Kondoh, H; Furutani-Seiki, M;
Keywords:primordial germ cells; vasa; olvas; genetic screen; maternal effect; cell migration; Medaka; Oryzias latipes;


Mutations affecting gonadal development in Medaka, Oryzias latipes
MECHANISMS OF DEVELOPMENT,121(7-8):829-839 2004(Jul.)
Author:Morinaga, C; Tomonaga, T; Sasado, T; Suwa, H; Niwa, K; Yasuoka, A; Henrich, T; Watanabe, T; Deguchi, T; Yoda, H; Hirose, Y; Iwanami, N; Kunimatsu, S; Okamoto, Y; Yamanaka, T; Shinomiya, A; Tanaka, M; Kondoh, H; Furutani-Seiki, M;
Keywords:gonad; mutant; screening; olvas; vasa; ftz-f1; sf-1; sex determination; sex differentiation; Medaka;


Mutations affecting liver development and function in Medaka, Oryzias latipes, screened by multiple criteria
MECHANISMS OF DEVELOPMENT,121(7-8):791-802 2004(Jul.)
Author:Watanabe, T; Asaka, S; Kitagawa, D; Saito, K; Kurashige, R; Sasado, T; Morinaga, C; Suwa, H; Niwa, K; Henrich, T; Hirose, Y; Yasuoka, A; Yoda, H; Deguchi, T; Iwanami, N; Kunimatsu, S; Osakada, M; Loosli, F; Quiring, R; Carl, M; Grabher, C; Winkler, S; Del Bene, F; Wittbrodt, J; Abe, K; Takahama, Y; Takahashi, K; Katada, T; Nishina, H; Kondoh, H; Furutani-Seiki, M;
Keywords:liver development; Medaka; hepatoblast; hepatic bud; laterality; gall bladder; lipid metabolism; endoderm formation; bile; zebrafish;


Transposon-mediated enhancer trapping in medaka (vol 322, pg 57, 2003)
GENE,327(2):239-239 2004
Author:Grabher, C; Henrich, T; Sasado, T; Arenz, A; Furutani-Seiki, M; Wittbrodt, J;


Transposon-mediated enhancer trapping in medaka
GENE,322:57-66 2003
Author:Grabher, C; Henrich, T; Sasado, T; Arenz, A; Wittbrodt, J; Furutani-Seiki, M;
Keywords:transgenesis; Sleeping Beauty; teleost; microinjection;


Expression of murine early embryonic antigens, SSEA-1 and antigenic determinant of EMA-1, in embryos and ovarian follicles of a teleost medaka (Oryzias latipes)
DEVELOPMENT GROWTH & DIFFERENTIATION,41(3):293-302 1999(Jun.)
Author:Sasado, T; Kani, S; Washimi, K; Ozato, K; Wakamatsu, Y;
Keywords:carbohydrate antigen; EMA-1; fish; medaka; SSEA-1;


Usefulness of the medaka beta-actin promoter investigated using a mutant GFP reporter gene in transgenic medaka (Oryzias latipes)
MOLECULAR MARINE BIOLOGY AND BIOTECHNOLOGY,7(3):173-180 1998(Sep.)
Author:Hamada, K; Tamaki, K; Sasado, T; Watai, Y; Kani, S; Wakamatsu, Y; Ozato, K; Kinoshita, M; Kohno, R; Takagi, S; Kimura, M;


Thyroid hormone-dependent repression of alpha 1-microglobulin/bikunin precursor (AMBP) gene expression during amphibian metamorphosis
DEVELOPMENT GENES AND EVOLUTION,206(6):355-362 1997(Jan.)
Author:Kawahara, A; Hikosaka, A; Sasado, T; Hirota, K;
Keywords:Xenopus metamorphosis; alpha1-microglobulin/bikunin precursor; Hepatocyte culture; gene expression;

研究費
科学研究費補助金(研究代表者)
2016 - 2020 , メダカ突然変異体群の解析による始原生殖細胞の移動を制御する新しい分子機構の解明 , 基盤(C)
2009 - 2013 , メダカ突然変異体の解析による始原生殖細胞の発生機構の解明 , 若手研究(B)
1995 - 1998 , メダカにおける遺伝子タ−ゲッティング技術の開発 , 特別研究員奨励費