佐藤 隆 (サトウ タカシ)
農学部
先鋭領域融合研究群 バイオメディカル研究所
特任教授（委嘱）
研究者情報
研究キーワード
- ナノ粒子, 免疫調節性DNA, 免疫制御
電話番号
- 0265-77-1403
経歴
学歴
研究活動情報
受賞
論文
- Development of engineered IL-36γ-hypersecreting Lactococcus lactis to improve the intestinal environment
Masahiro Yoda; Shogo Takase; Kaho Suzuki; Aito Murakami; Fu Namai; Takashi Sato; Tadashi Fujii; Takumi Tochio; Takeshi Shimosato*
World Journal of Microbiology and Biotechnology, in press, 2024年10月, 査読有り, 指定なし
筆頭著者
- Ad libitum feeding of silkworm larvae powder-containing diets specifically influences metabolism-related and short-chain fatty acid-producing gut bacteria in mice.
Aito Murakami; Haruka Yamaguchi; Fu Namai; Takashi Sato; Maki Yamazaki; Hiroshi Uehara; Tadashi Fujii; Takumi Tochio; Kunihiro Shiomi; Takeshi Shimosato
Frontiers in cellular and infection microbiology, 14, 1383774-1383774, 2024年, 指定なし
筆頭著者 - Oral administration of
Brevibacterium linens from washed cheese increases the proportions of short‐chain fatty acid‐producing bacteria and lactobacilli in the gut microbiota of mice
Aito Murakami; Koharu Toyomoto; Fu Namai; Takashi Sato; Tadashi Fujii; Takumi Tochio; Takeshi Shimosato
Animal Science Journal, 94(1), 2023年12月, 査読有り, 指定なし
筆頭著者 - CD62L expression marks SARS-CoV-2 memory B cell subset with preference for neutralizing epitopes
Taishi Onodera; Nicolas Sax; Takashi Sato; Yu Adachi; Ryutaro Kotaki; Takeshi Inoue; Ryo Shinnakasu; Takayuki Nakagawa; Shuetsu Fukushi; Tommy Terooatea; Mai Yoshikawa; Keisuke Tonouchi; Takaki Nagakura; Saya Moriyama; Takayuki Matsumura; Masanori Isogawa; Kazutaka Terahara; Tomohiro Takano; Lin Sun; Ayae Nishiyama; Shinnya Omoto; Masaharu Shinkai; Tomohiro Kurosaki; Kazuo Yamashita; Yoshimasa Takahashi
Science Advances, 9(24), 2023年06月, 査読有り, 指定なし
筆頭著者 - High Fever, Wide Distribution of Viral Pneumonia, and Pleural Effusion are More Critical Findings at the First Visit in Predicting the Prognosis of COVID-19: A Single Center, retrospective, Propensity Score-Matched Case–Control Study
Masahiro Shinoda; Shinichiro Ota; Yuto Yoshida; Takatomo Hirouchi; Kanako Shinada; Takashi Sato; Miwa Morikawa; Naoki Ishii; Masaharu Shinkai
International Journal of General Medicine, Volume 16, 2337-2348, 2023年06月, 査読有り, 指定なし
筆頭著者 - Development of a Single-Chain Fragment Variable that Binds to the SARS-CoV-2 Spike Protein Produced by Genetically Modified Lactic Acid Bacteria
Suzuka Oshima; Fu Namai; Takashi Sato; Takeshi Shimosato
Molecular Biotechnology, 2023年04月, 査読有り, 指定なし
責任著者 - Heterologous SARS-CoV-2 spike protein booster elicits durable and broad antibody responses against the receptor-binding domain.
Tomohiro Takano; Takashi Sato; Ryutaro Kotaki; Saya Moriyama; Shuetsu Fukushi; Masahiro Shinoda; Kiyomi Kabasawa; Nagashige Shimada; Mio Kousaka; Yu Adachi; Taishi Onodera; Kazutaka Terahara; Masanori Isogawa; Takayuki Matsumura; Masaharu Shinkai; Yoshimasa Takahashi
Nature communications, 14(1), 1451-1451, 2023年03月, 査読有り, 指定なし
筆頭著者 - Development of fluorescence-labeled antibody for immune checkpoint inhibitor using engineered probiotics
Fu Namai; Shunsuke Sumiya; Natsumi Nomura; Takashi Sato; Takeshi Shimosato
AMB Express, 13(1), 2023年01月, 査読有り, 指定なし
責任著者 - SARS-CoV-2 specific CD4+ T cell longevity correlates with Th17-like phenotype
Kazutaka Terahara; Takashi Sato; Yu Adachi; Keisuke Tonouchi; Taishi Onodera; Saya Moriyama; Lin Sun; Tomohiro Takano; Ayae Nishiyama; Ai Kawana-Tachikawa; Tetsuro Matano; Takayuki Matsumura; Masaharu Shinkai; Masanori Isogawa; Yoshimasa Takahashi
iScience, 104959-104959, 2022年08月, 査読有り, 指定なし
筆頭著者 - Immunogenicity and safety of booster dose of S-268019-b or BNT162b2 in Japanese participants: An interim report of phase 2/3, randomized, observer-blinded, noninferiority study
Masaharu Shinkai; Takuhiro Sonoyama; Akari Kamitani; Risa Yokokawa Shibata; Naomi M. Seki; Shinya Omoto; Masahiro Shinoda; Takashi Sato; Naoki Ishii; Kenji Igarashi; Mari Ariyasu
Vaccine, 2022年06月, 査読有り, 指定なし
筆頭著者 - Longitudinal Analysis of Neutralizing Potency against SARS-CoV-2 in the Recovered Patients after Treatment with or without Favipiravir
Kanako Shinada; Takashi Sato; Saya Moriyama; Yu Adachi; Masahiro Shinoda; Shinichiro Ota; Miwa Morikawa; Masamichi Mineshita; Takayuki Matsumura; Yoshimasa Takahashi; Masaharu Shinkai
Viruses, 14(4), 670-670, 2022年03月, 査読有り, 指定なし
責任著者 - Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients
Xiuyuan Lu; Yuki Hosono; Masamichi Nagae; Shigenari Ishizuka; Eri Ishikawa; Daisuke Motooka; Yuki Ozaki; Nicolas Sax; Yuichi Maeda; Yasuhiro Kato; Takayoshi Morita; Ryo Shinnakasu; Takeshi Inoue; Taishi Onodera; Takayuki Matsumura; Masaharu Shinkai; Takashi Sato; Shota Nakamura; Shunsuke Mori; Teru Kanda; Emi E. Nakayama; Tatsuo Shioda; Tomohiro Kurosaki; Kiyoshi Takeda; Atsushi Kumanogoh; Hisashi Arase; Hironori Nakagami; Kazuo Yamashita; Yoshimasa Takahashi; Sho Yamasaki
Journal of Experimental Medicine, 218(12), 2021年12月, 査読有り, 指定なし
筆頭著者 - Glycan engineering of the SARS-CoV-2 receptor-binding domain elicits cross-neutralizing antibodies for SARS-related viruses
Ryo Shinnakasu; Shuhei Sakakibara; Hiromi Yamamoto; Po-hung Wang; Saya Moriyama; Nicolas Sax; Chikako Ono; Atsushi Yamanaka; Yu Adachi; Taishi Onodera; Takashi Sato; Masaharu Shinkai; Ryosuke Suzuki; Yoshiharu Matsuura; Noritaka Hashii; Yoshimasa Takahashi; Takeshi Inoue; Kazuo Yamashita; Tomohiro Kurosaki
Journal of Experimental Medicine, 218(12), 2021年12月, 査読有り, 指定なし
筆頭著者 - Free feeding of CpG-oligodeoxynucleotide particles prophylactically attenuates allergic airway inflammation and hyperresponsiveness in mice
Takuma Okajima, Suguru Shigemori, Fu Namai, Tasuku Ogita, Takashi Sato and Takeshi Shimosato
Frontiers in Immunology, 2021年11月, 査読有り, 指定なし
筆頭著者 - Temporal maturation of neutralizing antibodies in COVID-19 convalescent individuals improves potency and breadth to circulating SARS-CoV-2 variants
Saya Moriyama; Yu Adachi; Takashi Sato; Keisuke Tonouchi; Lin Sun; Shuetsu Fukushi; Souichi Yamada; Hitomi Kinoshita; Kiyoko Nojima; Takayuki Kanno; Minoru Tobiume; Keita Ishijima; Yudai Kuroda; Eun-Sil Park; Taishi Onodera; Takayuki Matsumura; Tomohiro Takano; Kazutaka Terahara; Masanori Isogawa; Ayae Nishiyama; Ai Kawana-Tachikawa; Masaharu Shinkai; Natsuo Tachikawa; Shigeki Nakamura; Takahiro Okai; Kazu Okuma; Tetsuro Matano; Tsuguto Fujimoto; Ken Maeda; Makoto Ohnishi; Takaji Wakita; Tadaki Suzuki; Yoshimasa Takahashi
Immunity, 54(8), 1841-1852.e4, 2021年08月, 査読有り, 指定なし
筆頭著者 - Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17
Ayane Mikami; Tasuku Ogita; Fu Namai; Suguru Shigemori; Takashi Sato; Takeshi Shimosato
Frontiers in Nutrition, 7, 2021年02月, 査読有り, 指定なし
筆頭著者 - A case of COVID-19 pneumonia successfully treated with favipiravir (Avigan) in which serum SARS-CoV-2 RNA detected by LAMP method was clinically useful
Takatomo Hirouchi; Shinichiro Ota; Dai Mashima; Ryuichi Boku; Yuto Yoshida; Koki Iwata; Kanako Shinada; Takashi Matsumoto; Miwa Morikawa; Takashi Sato; Masahiro Shinoda; Kenichi Kamachi; Masaharu Shinkai
Journal of Infection and Chemotherapy, 27(2), 379-383, 2021年02月, 指定なし
筆頭著者 - Two cases of severe covid-19 pneumonia effectively treated with extracorporeal membrane oxygenation in addition to favipiravir and corticosteroid
Masahiro Shinoda; Kenichi Kamachi; Shinichiro Ota; Lynn Yoshimatsu; Ryuichi Boku; Yuto Yoshida; Takatomo Hirouchi; Kanako Shinada; Takashi Sato; Miwa Morikawa; Koki Iwata; Takashi Matsumoto; Masaharu Shinkai
Internal Medicine, 60(1), 123-130, 2021年01月, 指定なし
筆頭著者 - Construction of Genetically Modified Lactococcus lactis Producing Anti-human-CTLA-4 Single-Chain Fragment Variable
Fu Namai; Aito Murakami; Asami Ueda; Masami Tsukagoshi; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Takeshi Shimosato
Molecular Biotechnology, 62(11-12), 572-579, 2020年12月, 査読有り, 指定なし
筆頭著者 - Clinical Features of 154 COVID-19 Patients and the Parameters for the Effective Detection of Pneumonia at the Time of the Initial Diagnosis in Japan
Miwa Morikawa; Masahiro Shinoda; Shinichiro Ohta; Yuto Yoshida; Takatomo Hirouchi; Kanako Shinada; Osamu Sasaki; Takashi Sato; Kenichi Kamachi; Masaharu Shinkai
Internal Medicine, 2020年11月, 査読有り, 指定なし
責任著者 - Nasally Administered Lactococcus lactis Secreting Heme Oxygenase-1 Attenuates Murine Emphysema
Kentaro Yumoto; Takashi Sato; Kentaro Nakashima; Fu Namai; Suguru Shigemori; Takeshi Shimosato; Takeshi Kaneko
Antioxidants, 9(11), 1049-1049, 2020年10月, 査読有り, 指定なし
責任著者 - Construction of genetically modified Lactococcus lactis that produces bioactive anti-interleukin-4 single-chain fragment variable
Fu Namai; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Takeshi Shimosato
Molecular Biology Reports, 47(9), 7039-7047, 2020年09月, 査読有り, 指定なし
筆頭著者 - Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice
Fu Namai; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Takeshi Shimosato
Experimental & Molecular Medicine, 52(9), 1627-1636, 2020年09月, 査読有り, 指定なし
筆頭著者 - Oral administration of Flavonifractor plautii attenuates inflammatory responses in obese adipose tissue
Ayane Mikami; Tasuku Ogita; Fu Namai; Suguru Shigemori; Takashi Sato; Takeshi Shimosato
Molecular Biology Reports, 47(9), 6717-6725, 2020年09月, 査読有り, 招待無し
筆頭著者 - Ribosome-Engineered Lacticaseibacillus rhamnosus Strain GG Exhibits Cell Surface Glyceraldehyde-3-Phosphate Dehydrogenase Accumulation and Enhanced Adhesion to Human Colonic Mucin
Minori Ishida; Fu Namai; Suguru Shigemori; Shoko Kajikawa; Masami Tsukagoshi; Takashi Sato; Tasuku Ogita; Takeshi Shimosato
Applied and Environmental Microbiology, 86(20), 2020年08月, 査読有り, 招待無し
筆頭著者 - The clinical significance of CXCL16 in the treatment of advanced non‐small cell lung cancer
Yuji Shibata; Nobuaki Kobayashi; Takashi Sato; Kentaro Nakashima; Takeshi Kaneko
Thoracic Cancer, 11(5), 1258-1264, 2020年05月, 査読有り, 指定なし
責任著者 - Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice
Tasuku Ogita; Yoshinari Yamamoto; Ayane Mikami; Suguru Shigemori; Takashi Sato; Takeshi Shimosato
Frontiers in Immunology, 11, 2020年02月, 査読有り, 招待無し
筆頭著者 - Oral priming with oligodeoxynucleotide particles from Lactobacillus rhamnosus GG attenuates symptoms of dextran sodium sulfate‐induced acute colitis in mice
Suguru Shigemori; Fu Namai; Tasuku Ogita; Takashi Sato; Takeshi Shimosato
Animal Science Journal, 91(1), 2020年01月, 査読有り, 指定なし
筆頭著者 - Lactobacillus ingluviei C37 from chicken inhibits inflammation in LPS‐stimulated mouse macrophages
Masami Tsukagoshi; Merisa Sirisopapong; Fu Namai; Minori Ishida; Supattra Okrathok; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Sutisa Khempaka; Takeshi Shimosato
Animal Science Journal, 91(1), 2020年01月, 査読有り, 招待無し
筆頭著者 - Hepcidin exerts a negative immunological effect in pulmonary tuberculosis without HIV co-infection, prolonging the time to culture-negative.
Ken Tashiro; Masaki Yamamoto; Ryota Ushio; Nobuaki Kobayashi; Takashi Sato; Makoto Kudo; Takeshi Kaneko
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 86, 47-54, 2019年09月, 査読有り, 招待無し
筆頭著者 - Clinical significance of Charlson comorbidity index as a prognostic parameter for patients with acute or subacute idiopathic interstitial pneumonias and acute exacerbation of collagen vascular diseases-related interstitial pneumonia.
Kota Murohashi; Yu Hara; Yusuke Saigusa; Nobuaki Kobayashi; Takashi Sato; Masaki Yamamoto; Makoto Kudo; Takeshi Kaneko
Journal of thoracic disease, 11(6), 2448-2457, 2019年06月, 査読有り, 招待無し
筆頭著者 - Recombinant mouse calcitonin gene-related peptide secreted by Lactococcus lactis inhibits lipopolysaccharide-induced inflammatory response in macrophages.
Fu Namai; Yoshinari Yamamoto; Takashi Sato; Tasuku Ogita; Takeshi Shimosato
Animal science journal = Nihon chikusan Gakkaiho, 89(12), 1707-1711, 2018年12月, 査読有り, 招待無し
筆頭著者 - Silicosis and lung cancer: current perspectives
Sato T; Shimosato T; Klinman DM
Lung Cancer (Auckl), 9, 91-101, 2018年10月, 査読有り, 招待有り
筆頭著者 - Regulatory role of heme oxygenase-1 in silica-induced lung injury
Kentaro Nakashima; Takashi Sato; Suguru Shigemori; Takeshi Shimosato; Masaharu Shinkai; Takeshi Kaneko
Respiratory Research, 19(1), 2018年08月, 査読有り, 指定なし
責任著者
- Immune synergistic oligodeoxynucleotide from Lactobacillus rhamnosus GG enhances the immune response upon co-stimulation by bacterial and fungal cell wall components.
Nigar S; Yamamoto Y; Okajima T; Sato T; Ogita T; Shimosato T
Anim Sci J, 89(10), 1504-1511, 2018年07月, 査読有り, 招待無し
筆頭著者 - Recombinant Mouse Osteocalcin Secreted by Lactococcus lactis Promotes Glucagon-Like Peptide-1 Induction in STC-1 Cells.
Fu Namai; Suguru Shigemori; Koichi Sudo; Takashi Sato; Yoshinari Yamamoto; Shireen Nigar; Tasuku Ogita; Takeshi Shimosato
Current microbiology, 75(1), 92-98, 2018年01月, 査読有り, 招待無し
筆頭著者 - The platelet count can predict in-hospital death in hiv-negative smear-positive pulmonary tuberculosis inpatients
Hideto Goto; Nobuyuki Horita; Ken Tashiro; Kenjiro Nagai; Masaki Yamamoto; Takashi Sato; Yu Hara; Hideyuki Nagakura; Yuji Shibata; Hiroki Watanabe; Kentaro Nakashima; Ryota Ushio; Akimichi Nagashima; Misako Ikeda; Atsuya Narita; Katsuhito Sasaki; Nobuaki Kobayashi; Makoto Kudo; Takeshi Kaneko
Internal Medicine, 57(10), 1391-1397, 2018年, 査読有り, 招待無し
筆頭著者 - Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production
Shireen Nigar; Yoshinari Yamamoto; Takuma Okajima; Suguru Shigemori; Takashi Sato; Tasuku Ogita; Takeshi Shimosato
BMC IMMUNOLOGY, 18, 44, 2017年10月, 査読有り, 招待無し
筆頭著者 - Genetically modified Lactococcus lactis producing a green fluorescent protein bovine lactoferrin fusion protein suppresses proinflammatory cytokine expression in lipopolysaccharide-stimulated RAW 264.7 cells
S. Shigemori; F. Namai; Y. Yamamoto; S. Nigar; T. Sato; T. Ogita; T. Shimosato
JOURNAL OF DAIRY SCIENCE, 100(9), 7007-7015, 2017年09月, 査読有り, 招待無し
筆頭著者 - Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock via Activation of Platelet-Activating Factor Acetylhydrolase
Yoshinari Yamamoto; Ryu Sugimura; Takafumi Watanabe; Suguru Shigemori; Takuma Okajima; Shireen Nigar; Fu Namai; Takashi Sato; Tasuku Ogita; Takeshi Shimosato
FRONTIERS IN IMMUNOLOGY, 8, 1049, 2017年08月, 査読有り, 招待無し
筆頭著者 - HbA1c level cannot predict the treatment outcome of smearpositive non-multi-drug-resistant HIV-negative pulmonary tuberculosis inpatients
Ken Tashiro; Nobuyuki Horita; Kenjiro Nagai; Misako Ikeda; Masaharu Shinkai; Masaki Yamamoto; Takashi Sato; Yu Hara; Hideyuki Nagakura; Yuji Shibata; Hiroki Watanabe; Kentaro Nakashima; Ryota Ushio; Akimichi Nagashima; Atsuya Narita; Nobuaki Kobayashi; Makoto Kudo; Takeshi Kaneko
SCIENTIFIC REPORTS, 7, 46488, 2017年04月, 査読有り, 招待無し
筆頭著者 - Secretion of an immunoreactive single-chain variable fragment antibody against mouse interleukin 6 by Lactococcus lactis
Suguru Shigemori; Masaki Ihara; Takashi Sato; Yoshinari Yamamoto; Shireen Nigar; Tasuku Ogita; Takeshi Shimosato
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 101(1), 341-349, 2017年01月, 査読有り, 招待無し
筆頭著者 - Factors for Predicting Outcomes among Non-HIV Patients with Pulmonary Tuberculosis
Toshinori Tsukahara; Nobuyuki Horita; Ken Tashiro; Kenjiro Nagai; Masaharu Shinkai; Masaki Yamamoto; Takashi Sato; Yu Hara; Hideyuki Nagakura; Yuji Shibata; Hiroki Watanabe; Kentaro Nakashima; Ryota Ushio; Akimichi Nagashima; Misako Ikeda; Atsuya Narita; Katsuhito Sasaki; Nobuaki Kobayashi; Makoto Kudo; Takeshi Kaneko
INTERNAL MEDICINE, 56(24), 3277-3282, 2017年, 査読有り, 招待無し
筆頭著者 - Diagnostic test accuracy of loop-mediated isothermal amplification assay for Mycobacterium tuberculosis: systematic review and meta-analysis
Kenjiro Nagai; Nobuyuki Horita; Masaki Yamamoto; Toshinori Tsukahara; Hideyuki Nagakura; Ken Tashiro; Yuji Shibata; Hiroki Watanabe; Kentaro Nakashima; Ryota Ushio; Misako Ikeda; Atsuya Narita; Akinori Kanai; Takashi Sato; Takeshi Kaneko
SCIENTIFIC REPORTS, 6, 39090, 2016年12月, 査読有り, 招待無し
筆頭著者 - Clarithromycin Suppresses Chloride Channel Accessory 1 and Inhibits Interleukin-13-Induced Goblet Cell Hyperplasia in Human Bronchial Epithelial Cells
Akimichi Nagashima; Masaharu Shinkai; Masahiro Shinoda; Tadasuke Shimokawaji; Yasuhiro Kimura; Kei Mishina; Takashi Sato; Mariko Toda; Yoshiaki Inayama; Bruce K. Rubin; Takeshi Kaneko
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 60(11), 6585-6590, 2016年11月, 査読有り, 招待無し
筆頭著者 - Diagnostic test accuracy of anti-glycopeptidolipid-core IgA antibodies for Mycobacterium avium complex pulmonary disease: systematic review and meta-analysis
Yuji Shibata; Nobuyuki Horita; Masaki Yamamoto; Toshinori Tsukahara; Hideyuki Nagakura; Ken Tashiro; Hiroki Watanabe; Kenjiro Nagai; Kentaro Nakashima; Ryota Ushio; Misako Ikeda; Atsuya Narita; Akinori Kanai; Takashi Sato; Takeshi Kaneko
SCIENTIFIC REPORTS, 6, 29325, 2016年07月, 査読有り, 招待無し
筆頭著者 - Digital PCR assay detection of circulating Mycobacterium tuberculosis DNA in pulmonary tuberculosis patient plasma
Ryota Ushio; Masaki Yamamoto; Kentaro Nakashima; Hiroki Watanabe; Kenjiro Nagai; Yuji Shibata; Ken Tashiro; Toshinori Tsukahara; Hideyuki Nagakura; Nobuyuki Horita; Takashi Sato; Masaharu Shinkai; Makoto Kudo; Atsuhisa Ueda; Takeshi Kaneko
TUBERCULOSIS, 99, 47-53, 2016年07月, 査読有り, 招待無し
筆頭著者 - Use of nanoparticles to deliver immunomodulatory oligonucleotides
Dennis M. Klinman; Takashi Sato; Takeshi Shimosato
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 8(4), 631-637, 2016年07月, 査読有り, 招待有り
筆頭著者 - Development of a simple IgE-independent anaphylactic model using buckwheat antigen and B-type CpG oligodeoxynucleotide from Streptococcus thermophilus
Yoshinari Yamamoto; Suguru Shigemori; Shireen Nigar; Kazushi Oshiro; Yeqin Wang; Takashi Sato; Takeshi Shimosato
ANIMAL SCIENCE JOURNAL, 87(5), 710-717, 2016年05月, 査読有り, 招待無し
筆頭著者 - Multiple nodular pulmonary metastases of lung adenocarcinoma with epidermal growth factor receptor mutation
Natsuki Kawata; Miyo Inoue; Nobuyuki Horita; Koji Tomaru; Masaki Yamamoto; Takashi Sato; Naoki Miyazawa; Takeshi Kaneko
Respiratory Investigation, 54(2), 133-135, 2016年03月, 査読有り, 招待無し
筆頭著者 - Age, Dehydration, Respiratory Failure, Orientation Disturbance, and Blood Pressure Score Predicts In-hospital Mortality in HIV-negative Non-multidrug-resistant Smear-positive Pulmonary Tuberculosis in Japan
Kenjiro Nagai; Nobuyuki Horita; Takashi Sato; Masaki Yamamoto; Hideyuki Nagakura; Takeshi Kaneko
Scientific Reports, 6, 21610, 2016年02月, 査読有り, 招待無し
筆頭著者 - Amrubicin for relapsed small-cell lung cancer: a systematic review and meta-analysis of 803 patients
Nobuyuki Horita; Masaki Yamamoto; Takashi Sato; Toshinori Tsukahara; Hideyuki Nagakura; Ken Tashiro; Yuji Shibata; Hiroki Watanabe; Kenjiro Nagai; Kentaro Nakashima; Ryota Ushio; Misako Ikeda; Nobuaki Kobayashi; Masaharu Shinkai; Makoto Kudo; Takeshi Kaneko
SCIENTIFIC REPORTS, 6, 2016年01月, 査読有り, 招待無し
筆頭著者 - Sensitivity and specificity of Cobas TaqMan MTB real-time polymerase chain reaction for culture-proven Mycobacterium tuberculosis: meta-analysis of 26999 specimens from 17 Studies.
Nobuyuki Horita; Masaki Yamamoto; Takashi Sato; Toshinori Tsukahara; Hideyuki Nagakura; Ken Tashiro; Yuji Shibata; Hiroki Watanabe; Kenjiro Nagai; Kentaro Nakashima; Ryota Ushio; Misako Ikeda; Kentaro Sakamaki; Takashi Yoshiyama; Takeshi Kaneko
Scientific reports, 5, 18113-18113, 2015年12月, 査読有り, 招待無し
筆頭著者 - Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice
Suguru Shigemori; Takafumi Watanabe; Kai Kudoh; Masaki Ihara; Shireen Nigar; Yoshinari Yamamoto; Yoshihito Suda; Takashi Sato; Haruki Kitazawa; Takeshi Shimosato
MICROBIAL CELL FACTORIES, 14(1), 189, 2015年11月, 査読有り, 招待無し
筆頭著者 - Topotecan for Relapsed Small-cell Lung Cancer: Systematic Review and Meta-Analysis of 1347 Patients
Nobuyuki Horita; Masaki Yamamoto; Takashi Sato; Toshinori Tsukahara; Hideyuki Nagakura; Ken Tashiro; Yuji Shibata; Hiroki Watanabe; Kenjiro Nagai; Miyo Inoue; Kentaro Nakashima; Ryota Ushio; Masaharu Shinkai; Makoto Kudo; Takeshi Kaneko
SCIENTIFIC REPORTS, 5, 15437, 2015年10月, 査読有り, 招待無し
筆頭著者 - Intrapulmonary Delivery of CpG Microparticles Eliminates Lung Tumors
Takashi Sato; Takeshi Shimosato; Atsuhisa Ueda; Yoshiaki Ishigatsubo; Dennis M. Klinman
MOLECULAR CANCER THERAPEUTICS, 14(10), 2198-2205, 2015年10月, 査読有り, 招待無し
筆頭著者 - Inhibitory/Suppressive Oligodeoxynucleotide Nanocapsules as Simple Oral Delivery Devices for Preventing Atopic Dermatitis in Mice
Yeqin Wang; Yoshinari Yamamoto; Suguru Shigemori; Takafumi Watanabe; Kazushi Oshiro; Xinyu Wang; Pengfei Wang; Takashi Sato; Shinichi Yonekura; Sachi Tanaka; Haruki Kitazawa; Takeshi Shimosato
MOLECULAR THERAPY, 23(2), 297-309, 2015年02月, 査読有り, 招待無し
筆頭著者 - An Autopsy Case Report of Malignant Pleural Mesothelioma with Deciduoid Features
Ryota Ushio; Masaki Yamamoto; Yuji Shibata; Hiroshi Ishii; Keisuke Watanabe; Ryohei Takahashi; Takashi Sato; Makoto Kudo; Akio Miyake; Takeshi Kaneko; Yoshiaki Ishigatsubo
INTERNAL MEDICINE, 54(22), 2915-2917, 2015年, 査読有り, 招待無し
筆頭著者 - The effectiveness of sputum pH analysis in the prediction of response to therapy in patients with pulmonary tuberculosis.
Makoto Masuda; Takashi Sato; Kentaro Sakamaki; Makoto Kudo; Takeshi Kaneko; Yoshiaki Ishigatsubo
PeerJ, 3, e1448, 2015年, 査読有り, 招待無し
筆頭著者 - IKKα negatively regulates ASC-dependent inflammasome activation.
Martin BN; Wang C; Willette-Brown J; Herjan T; Gulen MF; Zhou H; Bulek K; Franchi L; Sato T
Nat Commun, 5, 4977, 2014年09月, 査読有り, 招待無し
筆頭著者 - Five cases of pulmonary tuberclosis in pregnancy
Ryohei Takahashi; Ryota Ushio; Yusuke Moriyama; Yuji Shibata; Hiroshi Ishii; Keisuke Watanabe; Masaki Yamamoto; Takashi Sato; Makoto Kudo; Takeshi Kaneko; Yoshiaki Ishigatsubo
Yokohama Medical Journal, 65(4), 559-563, 2014年, 指定なし
筆頭著者 - Generation of dipeptidyl peptidase-IV-inhibiting peptides from β-lactoglobulin secreted by Lactococcus lactis
Shigemori S; Oshiro K; Wang P; Yamamoto Y; Wang Y; Sato T; Uyeno Y; Shimosato T
BioMed Research International, 2014, 393598, 2014年, 査読有り, 招待無し
筆頭著者 - Expression of the immunoreactive buckwheat major allergenic storage protein in Lactococcus lactis
Suguru Shigemori; Shinichi Yonekura; Takashi Sato; Hajime Otani; Takeshi Shimosato
Applied Microbiology and Biotechnology, 97(8), 3603-3611, 2013年04月, 査読有り, 招待無し
筆頭著者 - Suppressive oligodeoxynucleotides synergistically enhance antiproliferative effects of anticancer drugs in A549 human lung cancer cells
Ryohei Takahashi; Takashi Sato; Dennis M. Klinman; Takeshi Shimosato; Takeshi Kaneko; Yoshiaki Ishigatsubo
International Journal of Oncology, 42(2), 429-436, 2013年02月, 査読有り, 招待無し
筆頭著者 - Development and validation of a tuberculosis prognostic score for smear-positive in-patients in Japan
N. Horita; N. Miyazawa; T. Yoshiyama; T. Sato; M. Yamamoto; K. Tomaru; M. Masuda; K. Tashiro; M. Sasaki; S. Morita; T. Kaneko; Y. Ishigatsubo
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 17(1), 54-60, 2013年01月, 査読有り, 招待無し
筆頭著者 - Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression
Yusuke Ito; Suguru Shigemori; Takashi Sato; Tomoyuki Shimazu; Konomi Hatano; Hajime Otani; Haruki Kitazawa; Takeshi Shimosato
FEBS OPEN BIO, 3, 41-45, 2013年, 査読有り, 招待無し
筆頭著者 - Serum Heme Oxygenase-1 as a Marker of Lung Function Decline in Patients With Chronic Silicosis
Takashi Sato; Yoshiaki Saito; Satoshi Inoue; Takeshi Shimosato; Shigeto Takagi; Takeshi Kaneko; Yoshiaki Ishigatsubo
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 54(12), 1461-1466, 2012年12月, 査読有り, 招待無し
筆頭著者 - Expression of a biologically active GFP-α(S1)-casein fusion protein in Lactococcus lactis.
Shigemori S; Yonekura S; Sato T; Nakanishi M; Otani H; Shimosato T
Curr Microbiol, 64(6), 569-575, 2012年06月, 査読有り, 招待無し
筆頭著者 - Synchronous lung and gastric cancers successfully treated with carboplatin and pemetrexed: A case report
Takashi Sato; Koji Tomaru; Tomoko Koide; Makoto Masuda; Masaki Yamamoto; Naoki Miyazawa; Yoshiaki Inayama; Takeshi Kaneko; Yoshiaki Ishigatsubo
Journal of Medical Case Reports, 6, 266, 2012年, 査読有り, 招待無し
筆頭著者 - The acceleration of wound healing in primates by the local administration of immunostimulatory CpG oligonucleotides
Masaki Yamamoto; Takashi Sato; Joel Beren; Daniela Verthelyi; Dennis M. Klinman
BIOMATERIALS, 32(18), 4238-4242, 2011年06月, 査読有り, 招待無し
筆頭著者 - Heterogeneity of the efficacy of the 23-valent pneumococcal polysaccharide vaccine caused by various underlying conditions of chronic pulmonary disease in older patients: prospective cohort study
Satoshi Inoue; Yuji Watanuki; Tetsuji Kaneko; Takashi Sato; Naoki Miyazawa; Takeshi Kaneko; Yoshiaki Ishigatsubo; Satoshi Morita; Yutaka Natsumeda; Shunsaku Mizushima
BMJ OPEN, 1(1), e000105, 2011年, 査読有り, 招待無し
筆頭著者 - Serum Heme Oxygenase-1 As Marker Of Lung Function Decline In Patients With Chronic Silicosis
T. Sato; N. Miyazawa; Y. Saito; R. Takahashi; T. Tsukahara; M. Hayashi; M. Yamamoto; K. Tomaru; M. Sasaki; T. Kaneko; Y. Ishigatsubo
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 183(12), 1461, 2011年, 査読有り, 招待無し
筆頭著者 - Accelerated wound healing mediated by activation of Toll-like receptor 9
Takashi Sato; Masaki Yamamoto; Takeshi Shimosato; Dennis M. Klinman
WOUND REPAIR AND REGENERATION, 18(6), 586-593, 2010年11月, 査読有り, 招待無し
筆頭著者 - CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9
Takeshi Shimosato; Megumi Fujimoto; Masanori Tohno; Takashi Sato; Mariko Tateo; Hajime Otani; Haruki Kitazawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 394(1), 81-86, 2010年03月, 査読有り, 招待無し
筆頭著者 - High frequency of β-lactamase-negative, ampicillin-resistant strains of Haemophilus influenzae in patients with chronic bronchitis in Japan
Inoue S; Watanuki Y; Miyazawa N; Kudo M; Sato T; Kobayashi N; Mishina K; Sasaki M; Kaneko T; Ishigatsubo Y
J Infect Chemother, 16(1), 72-75, 2010年02月, 査読有り, 招待無し
筆頭著者 - Esophagomediastinal and esophagobronchial fistulas associated with invasive aspergillosis.
Kato S; Inoue S; Inamori M; Miyazawa N; Sato T; Kobayashi N; Mishina K; Sasaki M; Ishigatsubo Y; Nakajima A
Endoscopy, 42 Suppl 2, E48-9, 2010年, 査読有り, 招待無し
筆頭著者 - [The preventive effect of 23-valent pneumococcal polysaccharide vaccine against drug-resistant Streptococcus pneumonia in patients with chronic respiratory disease].
Kobayashi N; Watanuki Y; Miyazawa N; Kudo M; Inoue S; Sato T; Mishina K; Takahashi H; Kaneko T; Ishigatsubo Y
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 47(12), 1063-1069, 2009年12月, 査読有り, 招待無し
筆頭著者 - CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases
Dennis M. Klinman; Sven Klaschik; Takashi Sato; Debbie Tross
ADVANCED DRUG DELIVERY REVIEWS, 61(3), 248-255, 2009年03月, 査読有り, 招待有り
筆頭著者 - Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ
Takeshi Shimosato; Masanori Tohno; Takashi Sato; Junko Nishimura; Yasushi Kawai; Tadao Saito; Haruki Kitazawa
ANIMAL SCIENCE JOURNAL, 80(5), 597-604, 2009年, 査読有り, 招待無し
筆頭著者 - Therapeutic Applications and Mechanisms Underlying the Activity of Immunosuppressive Oligonucleotides
Dennis M. Klinman; Debbie Tross; Sven Klaschik; Hidekazu Shirota; Takeshi Sato
OLIGONUCLEOTIDE THERAPEUTICS, 1175, 80-88, 2009年, 査読有り, 招待有り
筆頭著者 - Synthetic oligonucleotides as modulators of inflammation
Dennis Klinman; Hidekazu Shirota; Debra Tross; Takashi Sato; Sven Klaschik
JOURNAL OF LEUKOCYTE BIOLOGY, 84(4), 958-964, 2008年10月, 査読有り, 招待有り
筆頭著者 - Suppressive oligodeoxynucleotides inhibit silica-induced pulmonary inflammation
Takashi Sato; Takeshi Shimosato; W. Gregory Alvord; Dennis M. Klinman
JOURNAL OF IMMUNOLOGY, 180(11), 7648-7654, 2008年06月, 査読有り, 招待無し
筆頭著者 - Heme oxygenase-1, a potential biomarker of chronic silicosis, attenuates silica-induced lung injury
Takashi Sato; Mitsuhiro Takeno; Koichi Honma; Hicleyuki Yamauchi; Yoshiaki Saito; Takao Sasaki; Hiroshi Morikubo; Yoji Nagashima; Shigeto Takagi; Kouichi Yamanaka; Takeshi Kaneko; Yoshiaki Ishigatsubo
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 174(8), 906-914, 2006年10月, 査読有り, 招待無し
筆頭著者 - Heme oxygenase-1 inhibits cigarette smoke-induced increase in the tracheal mucosal permeability in guinea pigs in vivo
A Tagawa; T Kaneko; T Shinohara; A Ueda; T Sato; Y Ishigatsubo
INFLAMMATION RESEARCH, 54(5), 229-234, 2005年05月, 査読有り, 招待無し
筆頭著者 - Cigarette smoke increases mucosal permeability in guinea pig trachea via tachykinin NK2 receptor activation
A Tagawa; T Kaneko; H Nishiyama; T Shinohara; T Sato; P Geppetti; Y Ishigatsubo
EUROPEAN JOURNAL OF PHARMACOLOGY, 507(1-3), 223-228, 2005年01月, 査読有り, 招待無し
筆頭著者 - Development of fluorescence-labeled antibody for immune checkpoint inhibitor using engineered probiotics
Fu Namai; Shunsuke Sumiya; Natsumi Nomura; Takashi Sato; Takeshi Shimosato
責任著者 - Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice
Fu Namai; Suguru Shigemori; Tasuku Ogita; Takashi Sato; Takeshi Shimosato - Ribosome-Engineered Lacticaseibacillus rhamnosus Strain GG Exhibits Cell Surface Glyceraldehyde-3-Phosphate Dehydrogenase Accumulation and Enhanced Adhesion to Human Colonic Mucin
Minori Ishida; Fu Namai; Suguru Shigemori; Shoko Kajikawa; Masami Tsukagoshi; Takashi Sato; Tasuku Ogita; Takeshi Shimosato - The platelet count can predict in-hospital death in hiv-negative smear-positive pulmonary tuberculosis inpatients
Hideto Goto; Nobuyuki Horita; Ken Tashiro; Kenjiro Nagai; Masaki Yamamoto; Takashi Sato; Yu Hara; Hideyuki Nagakura; Yuji Shibata; Hiroki Watanabe; Kentaro Nakashima; Ryota Ushio; Akimichi Nagashima; Misako Ikeda; Atsuya Narita; Katsuhito Sasaki; Nobuaki Kobayashi; Makoto Kudo; Takeshi Kaneko - Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production
Shireen Nigar; Yoshinari Yamamoto; Takuma Okajima; Suguru Shigemori; Takashi Sato; Tasuku Ogita; Takeshi Shimosato - Factors for Predicting Outcomes among Non-HIV Patients with Pulmonary Tuberculosis
Toshinori Tsukahara; Nobuyuki Horita; Ken Tashiro; Kenjiro Nagai; Masaharu Shinkai; Masaki Yamamoto; Takashi Sato; Yu Hara; Hideyuki Nagakura; Yuji Shibata; Hiroki Watanabe; Kentaro Nakashima; Ryota Ushio; Akimichi Nagashima; Misako Ikeda; Atsuya Narita; Katsuhito Sasaki; Nobuaki Kobayashi; Makoto Kudo; Takeshi Kaneko - Age, Dehydration, Respiratory Failure, Orientation Disturbance, and Blood Pressure Score Predicts In-hospital Mortality in HIV-negative Non-multidrug-resistant Smear-positive Pulmonary Tuberculosis in Japan
Kenjiro Nagai; Nobuyuki Horita; Takashi Sato; Masaki Yamamoto; Hideyuki Nagakura; Takeshi Kaneko - Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice
Suguru Shigemori; Takafumi Watanabe; Kai Kudoh; Masaki Ihara; Shireen Nigar; Yoshinari Yamamoto; Yoshihito Suda; Takashi Sato; Haruki Kitazawa; Takeshi Shimosato - Suppressive oligodeoxynucleotides synergistically enhance antiproliferative effects of anticancer drugs in A549 human lung cancer cells
Ryohei Takahashi; Takashi Sato; Dennis M. Klinman; Takeshi Shimosato; Takeshi Kaneko; Yoshiaki Ishigatsubo - Development and validation of a tuberculosis prognostic score for smear-positive in-patients in Japan
N. Horita; N. Miyazawa; T. Yoshiyama; T. Sato; M. Yamamoto; K. Tomaru; M. Masuda; K. Tashiro; M. Sasaki; S. Morita; T. Kaneko; Y. Ishigatsubo - Synchronous lung and gastric cancers successfully treated with carboplatin and pemetrexed: A case report
Takashi Sato; Koji Tomaru; Tomoko Koide; Makoto Masuda; Masaki Yamamoto; Naoki Miyazawa; Yoshiaki Inayama; Takeshi Kaneko; Yoshiaki Ishigatsubo - Heterogeneity of the efficacy of the 23-valent pneumococcal polysaccharide vaccine caused by various underlying conditions of chronic pulmonary disease in older patients: prospective cohort study
Satoshi Inoue; Yuji Watanuki; Tetsuji Kaneko; Takashi Sato; Naoki Miyazawa; Takeshi Kaneko; Yoshiaki Ishigatsubo; Satoshi Morita; Yutaka Natsumeda; Shunsaku Mizushima - Heme oxygenase-1, a potential biomarker of chronic silicosis, attenuates silica-induced lung injury
Takashi Sato; Mitsuhiro Takeno; Koichi Honma; Hicleyuki Yamauchi; Yoshiaki Saito; Takao Sasaki; Hiroshi Morikubo; Yoji Nagashima; Shigeto Takagi; Kouichi Yamanaka; Takeshi Kaneko; Yoshiaki Ishigatsubo - Heme oxygenase-1 inhibits cigarette smoke-induced increase in the tracheal mucosal permeability in guinea pigs in vivo
A Tagawa; T Kaneko; T Shinohara; A Ueda; T Sato; Y Ishigatsubo - Oral administration of
Brevibacterium linens from washed cheese increases the proportions of short‐chain fatty acid‐producing bacteria and lactobacilli in the gut microbiota of mice
Aito Murakami; Koharu Toyomoto; Fu Namai; Takashi Sato; Tadashi Fujii; Takumi Tochio; Takeshi Shimosato
MISC
- Intratracheal therapy using nintedanib amorphous particles in murine pulmonary fibrosis
K. Suzuki; F. Namai; A. Murakami; Y. Sato; A. Kotsugai; T. Shimosato; T. Sato
European Respiratory Journal, 64(suppl 68), OA4557-OA4557, 2024年09月14日
筆頭著者 - Effect of Local Intratracheal Therapy Using Particleized Nintedanib in a Murine Model of Pulmonary Fibrosis
K. Suzuki; F. Namai; N. Nomura; Y. Sato; A. Kotsugai; T. Shimosato; T. Sato
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 207, A6476, 2023年05月01日
筆頭著者 - Intranasal Administration of Genetically Modified Lactococcus Lactis Producing PD-L1 scFv Improves Survival in Lung Cancer Model Mice
N. Nomura; F. Namai; T. Sato; T. Shimosato
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 207, A5754, 2023年05月01日
筆頭著者 - A Case of Adenocarcinoma of the Lung With EGFR T790 Mutation Presenting With Chylous Ascites.
Kentaro Nakashima; Yu Hara; Takashi Sato; Masaharu Shinkai; Takeshi Kaneko
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 13(8), 1227-1228, 2018年08月, 査読有り
筆頭著者 - Toll-Like Receptor 9, A Key To Attenuate Disease Progression In A Murine Model Of COPD
T. Sato; K. Nakashima; Y. Shibata; H. Sasaki; M. Ikeda; A. Nagashima; H. Watanabe; K. Nagai; H. Nagakura; N. Horita; N. Kobayashi; M. Yamamoto; M. Kudo; M. Shinkai; T. Kaneko
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 195, 2017年
筆頭著者 - Serum Cxcl16 As A Potential Prognostic Marker In Advanced Non Small Cell Lung Cancer
Y. Shibata; T. Sato; M. Ikeda; H. Sasaki; A. Nagashima; R. Ushio; K. Nakashima; H. Watanabe; K. Nagai; K. Tashiro; H. Nagakura; N. Horita; Y. Hara; N. Kobayashi; M. Yamamoto; M. Kudo; M. Shinkai; T. Kaneko
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 195, 2017年
筆頭著者 - Toll-Like Receptor 9, A Key To Attenuation Of Disease Progression In A Mouse Model Of Chronic Obstructive Pulmonary Disease
T. Sato; K. Nakashima; Y. Shibata; R. Ushio; M. Ikeda; H. Watanabe; K. Nagai; K. Tashiro; H. Nagakura; N. Horita; M. Yamamoto; M. Shinkai; M. Kudo; D. Klinman; T. Kaneko
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 193, 2016年
筆頭著者 - Heme Oxygenase-1 Regulates Ros-Erk1/2 Signaling In Silica-Induced Lung Injury
K. Nakashima; T. Sato; Y. Shibata; R. Ushio; M. Ikeda; H. Watanabe; K. Nagai; K. Tashiro; H. Nagakura; N. Horita; M. Yamamoto; M. Shinkai; M. Kudo; T. Kaneko
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 193, 2016年
筆頭著者 - Serum Cxcl16, A Potential Prognostic Marker In Advanced Non Small Cell Lung Cancer: A Preliminary Report
Y. Shibata; T. Sato; M. Yamamoto; M. Kudo; T. Kaneko; Y. Ishigatsubo
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 191, 2015年
筆頭著者 - Effect Of Intratracheal Immunostimulatory-Oligonucleotides With Biodegradable Polyketal Nanoparticles On Murine Lung Cancer
T. Sato; Y. Shibata; M. Yamamoto; M. Kudo; T. Kaneko; Y. Ishigatsubo; D. Klinman
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 191, 2015年
筆頭著者 - Suppressive Oligodeoxynucleotide Synergistically Enhances The Antiproliferative Effect Of Anti-Cancer Drug In Human Lung Cancer Cells
R. Takahashi; T. Sato; N. Miyazawa; D. M. Klinman; T. Shimosato; M. Hayashi; M. Yamamoto; K. Tomaru; T. Tsukahara; M. Sasaki; T. Kaneko; Y. Ishigatsubo
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 183, 2011年
筆頭著者 - CPG Oligodeoxynucleotides Promote Wound Healing In Airway Epithelial Cells
T. Sato; N. Miyazawa; D. M. Klinman; T. Shimosato; R. Takahashi; T. Tsukahara; M. Hayashi; M. Yamamoto; K. Tomaru; M. Sasaki; T. Kaneko; Y. Ishigatsubo
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 183, 2011年
筆頭著者 - Accelerated wound healing in mice by local administration of sustained-release CpG oligodeoxynucleotide
Takashi Sato; Takeshi Shimosato; Masaki Yamamoto; Nobuaki Kobayashi; Naoki Miyazawa; Yoshiaki Ishigatsubo; Dennis Klinman
JOURNAL OF IMMUNOLOGY, 184, 2010年04月
筆頭著者 - CpG oligodeoxynucleotide incorporated basement membrane extract facilitate wound repair in mice
Takashi Sato; Takeshi Shimosato; Dennis M. Klinman
JOURNAL OF IMMUNOLOGY, 182, 2009年04月
筆頭著者
書籍等出版物
- 組換え乳酸菌による肺がん免疫治療
佐藤 隆, 単著
Precision Medicine 2024;7(7):554-58, 2024年06月 - 組換え乳酸菌による医薬・ワクチン開発
佐藤 隆, 単著
BIO Clinica 2024;39(6):531-35, 2024年06月 - 組換え乳酸菌による肺癌免疫治療
佐藤 隆, 単著, クリニカルトピックス
BIO Clinica 2023;38(7):638-42, 2023年06月 - Book title: Chronic Obstructive Pulmonary Disease - A Compendium of Medicine and the Humanities
Takashi Sato; Takeshi Shimosato, 分担執筆, Chapter title: Intratracheally therapeutic option for COPD: a potential usage of the therapeutic microbe for delivering specific protein to the lungs
IntechOpen, 2022年08月17日, 査読有り - Book title: Chronic Obstructive Pulmonary Disease - A Compendium of Medicine and the Humanities
Takashi Sato; Takeshi Shimosato, 分担執筆, Chapter title: Intratracheally therapeutic option for COPD: a potential usage of the therapeutic microbe for delivering specific protein to the lungs
IntechOpen, 2022年08月, 査読有り
ISBN:9781803567679
https://www.intechopen.com/online-first/83110 - Development of a New Treatment Modality for Lung Diseases That Uses Innovative Fine Droplet Drying (FDD) Technology Offering Inhalable Nano/microparticles-incorporated Therapeutic Agents
佐藤 隆; 下里剛士, 単著
Science Impact Ltd, 2019年03月 - Respiratory Disease Series: Diagnostic Tools and Disease Managements: Chapter 14: Pharmacokinetics, Pharmacodynamics, and Toxicities: What Should We Know About Genetic Factors that Affect the Pharmacotherapy of Pulmonary Diseases?
佐藤 隆, 単著, Chapter 14: Pharmacokinetics, Pharmacodynamics, and Toxicities: What Should We Know About Genetic Factors that Affect the Pharmacotherapy of Pulmonary Diseases?
Springer, 255-271 2018年07月
ISBN:9789811081439 - ガイトン生理学（原著第13版）
佐藤 隆, 単訳, 第40章 肺胞を拡散する酸素と二酸化炭素のガス交換の原理、第41章 血液や組織液中の酸素と二酸化炭素の輸送
ELSEVIER, 2018年03月
ISBN:9784860347741
講演・口頭発表等
- Intratracheal therapy using oligodeoxynucleotides and/or genetically modified lactic acid bacteria-derived biological molecules
Takashi Sato
The Korean Society of Toxicology/The Korean Environmental Mutagen Society 2022 KSOT/KEMS Spring International Symposium, 2022年05月, 招待有り, - Innovative therapy for lung cancer ～Intratracheal delivery of nanomicroparticles-incorporated immune checkpoint-blocking single-chain variable fragment～
佐藤 隆
米国国立衛生研究所・国立癌研究所 Symposium on Innate Immunity & Modulation of the Host Immune Response in Honor of the Career of Dr. Dennis Klinman, 2019年06月, 招待有り - 吸入治療イノベーション～吸入薬で肺癌の制御を目指す研究開発の取り組み～
佐藤 隆
横浜市立大学先端医科学研究センター 第54回市民講座, 2018年10月, 招待無し - Intratracheal delivery of immunostimulatory oligonucleotides using biodegradable polyketal nanoparticles: effect of long-term immune responses on murine lung cancer
Takashi Sato
THE 14TH US-JAPAN SYMPOSIUM ON DRUG DELIVERY SYSTEMS, 2017年12月, 指定なし, - Intratracheal delivery of immunostimulatory oligonucleotides using biodegradable polyketal nanoparticles: effect on murine lung cancer
Takashi Sato
THE 13TH US-JAPAN SYMPOSIUM ON DRUG DELIVERY SYSTEMS, 2015年12月, 指定なし,
共同研究・競争的資金等の研究課題
- 組換え乳酸菌による新型コロナウイルス経気道粘膜ワクチン・治療薬の基盤構築
科学研究費補助金, 日本学術振興会, 基盤研究(C)
2022年04月 - 2025年03月 - 免疫チェックポイント阻害乳酸菌による肺癌発癌予防・進展予防効果の検証
科学研究費補助金, テキサス大学MDアンダーソンがんセンター, 国際共同研究加速基金（国際共同研究強化（B））
2019年10月 - 2023年03月 - 吸入療法イノベーションの実現：高分子・抗体医薬の経気道投与による肺癌治療戦略
科学研究費補助金, 挑戦的研究（萌芽）
2018年06月 - 2020年03月 - ライフイノベーションプラットフォーム横浜推進プロジェクト・圧電素子を用いた経気道投与用パーソナル吸入デバイスの開発研究
横浜市経済局
2017年09月 - 2020年03月 - 乳酸菌オリゴDNAを有効成分とする経口用ナノカプセルを用いた免疫調節機構の解明
科学研究費補助金, 基盤B
2017年04月 - 2021年03月 - 日本医療研究開発機構（AMED)・創薬基盤推進研究事業・Fine Droplet Dryingテクノロジーによる経気道治療用ナノマイクロ粒子包埋医薬品の創出を目指した研究
日本医療研究開発機構（AMED）
2017年04月 - 2020年03月 - ナノ粒子化免疫調節剤の呼吸器疾患への治療応用の研究
科学研究費補助金, 基盤C
2015年04月 - 2018年03月 - 微生物由来 DNA を利用した吸入型炎症性肺疾患治療薬の開発
科学研究費補助金, 若手B
2011年04月 - 2012年05月 - 免疫調節性DNAとナノ・マイクロ粒子キャリアーを用いた吸入型DNA治療薬の開発
科学研究費補助金, 若手B
2009年04月 - 2011年03月
産業財産権
- Polyketal particles including a CpG oligodeoxynucleotide for the treatment of lung cancer, 9919058, 2015039574, 15326387, 特許権
Takashi Sato, Dennis Klinman - Method of treating pneumoconiosis with oligodeoxynucleotides, 8222225, 2009044739, 12993809, 特許権
Takashi Sato, Dennis Klinman - Use of CpG oligodeoxynucleotides to induce epithelial cell growth, 8466116, 20090099122, 12205756, 特許権
Takashi Sato、Dennis Klinman
