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佐藤 隆  サトウ タカシ

教員組織農学部電話番号0265-77-1403
教育組織先鋭領域融合研究群 バイオメディカル研究所 生体分子イノベーション部門FAX番号0265-77-1403
職名特任教授(委嘱)メールアドレス
住所〒399-4598 長野県上伊那郡南箕輪村8304ホームページURL

更新日:2022/04/12

プロフィール

研究分野
キーワード:ナノ粒子 , 免疫調節性DNA , 免疫制御
所属学会
所属学会
日本臨床腫瘍学会
日本感染症学会
日本化学療法学会
日本アレルギー学会
日本酪農科学会
日本呼吸器学会
日本内科学会
米国胸部疾患学会

所属学会役職担当
2012-2015 , 米国胸部疾患学会 , プログラム委員
2008-2010 , 米国胸部疾患学会 , プログラム委員
学歴
出身大学院
2006 , 横浜市立大学 , 医学研究科 , 病態免疫制御内科学

出身学校・専攻等(大学院を除く)
2000 , 横浜市立大学 , 医学部 , 医学科
1994 , 東京工業大学 , 工学部 , 機械宇宙学科

取得学位
博士(医学) , 横浜市立大学

免許・資格等
2016 , 日本呼吸器学会呼吸器指導医
2010 , 日本内科学会総合内科専門医
2009 , 日本呼吸器学会呼吸器専門医
2000 , 医師免許
受賞学術賞
2013 , 米国国立衛生研究所(NIH)Fellows Award for Research Excellence (FARE) 2014
2013 , 米国国立衛生研究所(NIH)Appreciation Award
2009 , 横浜市立大学第一内科同門会賞
2008 , 神奈川難病財団研究奨励賞
2007 , The Oak Ridge Institute for Science and Education (ORISE) Research Award
2007 , 横浜総合医学振興財団呼吸器疾患研究賞
研究職歴等
研究職歴
2020- , 東京品川病院 腫瘍内科部長・研究センター長
2019- , 信州大学先鋭領域融合研究群・バイオメディカル研究所・特任教授
2019-2019 , 信州大学・農学部・特任准教授
2014-2019 , 横浜市立大学医学部・附属病院呼吸器内科・講師
2008-2012 , 横浜市立大学医学部・附属病院呼吸器内科・助教

留学歴
2012-2014 , 米国国立衛生研究所(NIH)国立がん研究所(NCI)
2007-2008 , 米国国立衛生研究所(NIH)国立がん研究所(NCI)
2005-2006 , 米国食品医薬品局(FDA)生物製剤評価研究センター(CBER)

研究活動業績

研究業績(著書・
発表論文等)
書籍等出版物
Development of a New Treatment Modality for Lung Diseases That Uses Innovative Fine Droplet Drying (FDD) Technology Offering Inhalable Nano/microparticles-incorporated Therapeutic Agents, Development of a New Treatment Modality for Lung Diseases That Uses Innovative Fine Droplet Drying (FDD) Technology Offering Inhalable Nano/microparticles-incorporated Therapeutic Agents
Science Impact Ltd 2019(Mar.)
Author:SATO Takashi、SHIMOSATO Takeshi


Chapter 14: Pharmacokinetics, Pharmacodynamics, and Toxicities: What Should We Know About Genetic Factors that Affect the Pharmacotherapy of Pulmonary Diseases?, Respiratory Disease Series: Diagnostic Tools and Disease Managements: Chapter 14: Pharmacokinetics, Pharmacodynamics, and Toxicities: What Should We Know About Genetic Factors that Affect the Pharmacotherapy of Pulmonary Diseases?
Springer 2018(Jul.)
Author:SATO Takashi


第40章 肺胞を拡散する酸素と二酸化炭素のガス交換の原理、第41章 血液や組織液中の酸素と二酸化炭素の輸送, ガイトン生理学(原著第13版)
2018(Mar.)
Author:佐藤 隆


論文
Temporal maturation of neutralizing antibodies in COVID-19 convalescent individuals improves potency and breadth to circulating SARS-CoV-2 variants
Immunity,54(8):1841-1852 2021(Jul.)
Author:Saya Moriyama, Yu Adachi, Takashi Sato, Keisuke Tonouchi, Lin Sun, Shuetsu Fukushi, Souichi Yamada, Hitomi Kinoshita, Kiyoko Nojima, Takayuki Kanno, Minoru Tobiume, Keita Ishijima, Yudai Kuroda, Eun-Sil Park, Taishi Onodera, Takayuki Matsumura, Tomohiro Takano, Kazutaka Terahara, Masanori Isogawa, Ayae Nishiyama, Ai Kawana-Tachikawa, Masaharu Shinkai, Natsuo Tachikawa, Shigeki Nakamura, Takahiro Okai, Kazu Okuma, Tetsuro Matano, Tsuguto Fujimoto, Ken Maeda, Makoto Ohnishi, Takaji Wakita, Tadaki Suzuki, Yoshimasa Takahashi


Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17
Frontiers in Nutrition,7:610946 2021(Feb. 04)
Author:Ayane Mikami, Tasuku Ogita, Fu Namai, Suguru Shigemori, Takashi Sato, Takeshi Shimosato


Construction of Genetically Modified Lactococcus lactis Producing Anti-human-CTLA-4 Single-Chain Fragment Variable
Molecular Biotechnology,62(11-12):572-579 2020(Dec.)
Author:Fu Namai, Aito Murakami, Asami Ueda, Masami Tsukagoshi, Suguru Shigemori, Tasuku Ogita, Takashi Sato, Takeshi Shimosato


Clinical Features of 154 COVID-19 Patients and the Parameters for the Effective Detection of Pneumonia at the Time of the Initial Diagnosis in Japan
Internal Medicine,60(1):31-37 2020(Nov.)
Author:Miwa Morikawa, Masahiro Shinoda, Shinichiro Ohta, Yuto Yoshida, Takatomo Hirouchi, Kanako Shinada, Osamu Sasaki, Takashi Sato, Kenichi Kamachi, Masaharu Shinkai


Nasally Administered Lactococcus lactis Secreting Heme Oxygenase-1 Attenuates Murine Emphysema
Antioxidants,9(11):1049-1049 2020(Oct. 27)
Author:Kentaro Yumoto, Takashi Sato, Kentaro Nakashima, Fu Namai, Suguru Shigemori, Takeshi Shimosato, Takeshi Kaneko


Construction of genetically modified Lactococcus lactis that produces bioactive anti-interleukin-4 single-chain fragment variable
Molecular Biology Reports,47(9):7039-7047 2020(Sep.)
Author:Fu Namai, Suguru Shigemori, Tasuku Ogita, Takashi Sato, Takeshi Shimosato


Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice
Experimental & Molecular Medicine,52(9):1627-1636 2020(Sep.)
Author:Fu Namai, Suguru Shigemori, Tasuku Ogita, Takashi Sato, Takeshi Shimosato


Oral administration of Flavonifractor plautii attenuates inflammatory responses in obese adipose tissue
Molecular Biology Reports,47(9):6717-6725 2020(Sep.)
Author:Ayane Mikami, Tasuku Ogita, Fu Namai, Suguru Shigemori, Takashi Sato, Takeshi Shimosato


Ribosome-Engineered Lacticaseibacillus rhamnosus Strain GG Exhibits Cell Surface Glyceraldehyde-3-Phosphate Dehydrogenase Accumulation and Enhanced Adhesion to Human Colonic Mucin
Applied and Environmental Microbiology,86(20):e01448-20 2020(Aug. 14)
Author:Minori Ishida, Fu Namai, Suguru Shigemori, Shoko Kajikawa, Masami Tsukagoshi, Takashi Sato, Tasuku Ogita, Takeshi Shimosato


The clinical significance of CXCL16 in the treatment of advanced non‐small cell lung cancer
Thoracic Cancer,11(5):1258-1264 2020(May)
Author:Yuji Shibata, Nobuaki Kobayashi, Takashi Sato, Kentaro Nakashima, Takeshi Kaneko


Oral Administration of Flavonifractor plautii Strongly Suppresses Th2 Immune Responses in Mice
Frontiers in Immunology,11:379 2020(Feb. 28)
Author:Tasuku Ogita, Yoshinari Yamamoto, Ayane Mikami, Suguru Shigemori, Takashi Sato, Takeshi Shimosato


Oral priming with oligodeoxynucleotide particles from Lactobacillus rhamnosus GG attenuates symptoms of dextran sodium sulfate‐induced acute colitis in mice
Animal Science Journal,91(1):e13468 2020(Jan.)
Author:Suguru Shigemori, Fu Namai, Tasuku Ogita, Takashi Sato, Takeshi Shimosato


Lactobacillus ingluviei C37 from chicken inhibits inflammation in LPS‐stimulated mouse macrophages
Animal Science Journal,91(1):e13436 2020(Jan.)
Author:Masami Tsukagoshi, Merisa Sirisopapong, Fu Namai, Minori Ishida, Supattra Okrathok, Suguru Shigemori, Tasuku Ogita, Takashi Sato, Sutisa Khempaka, Takeshi Shimosato


Hepcidin exerts a negative immunological effect in pulmonary tuberculosis without HIV co-infection, prolonging the time to culture-negative
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases,86:47-54 2019(Sep.)
Author:Ken Tashiro, Masaki Yamamoto, Ryota Ushio, Nobuaki Kobayashi, Takashi Sato, Makoto Kudo, Takeshi Kaneko


Clinical significance of Charlson comorbidity index as a prognostic parameter for patients with acute or subacute idiopathic interstitial pneumonias and acute exacerbation of collagen vascular diseases-related interstitial pneumonia
Journal of thoracic disease,11(6):2448-2457 2019(Jun.)
Author:Kota Murohashi, Yu Hara, Yusuke Saigusa, Nobuaki Kobayashi, Takashi Sato, Masaki Yamamoto, Makoto Kudo, Takeshi Kaneko


Recombinant mouse calcitonin gene-related peptide secreted by Lactococcus lactis inhibits lipopolysaccharide-induced inflammatory response in macrophages
Anim Sci J,89(12):1707-1711 2018(Dec.)
Author:Namai F, Yamamoto Y, Sato T, Ogita T, Shimosato T


Silicosis and lung cancer: current perspectives
Lung Cancer (Auckl),9:91-101 2018(Oct.)
Author:Sato T, Shimosato T, Klinman DM


Regulatory role of heme oxygenase-1 in silica-induced lung injury.
Respiratory Research,19(1):144 2018(Aug.)
Author:Nakashima K, Sato T, Shigemori S, Shimosato T, Shinkai M, Kaneko T


Immune synergistic oligodeoxynucleotide from Lactobacillus rhamnosus GG enhances the immune response upon co-stimulation by bacterial and fungal cell wall components.
Anim Sci J,89(10):1504-1511 2018(Jul.)
Author:Nigar S, Yamamoto Y, Okajima T, Sato T, Ogita T, Shimosato T


Recombinant Mouse Osteocalcin Secreted by Lactococcus lactis Promotes Glucagon-Like Peptide-1 Induction in STC-1 Cells
Current Microbiology,75(1):92-98 2018(Jan.)
Author:Namai F, Shigemori S, Sudo K, Sato T, Yamamoto Y, Nigar S, Ogita T, Shimosato T


Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production
BMC Immunology,18:44 2017(Oct.)
Author:Nigar S, Yamamoto Y, Okajima T, Shigemori S, Sato T, Ogita T, Shimosato T


Genetically modified Lactococcus lactis producing a green fluorescence protein-bovine lactoferrin fusion protein suppresses proinflammatory cytokine expression in lipopolysaccharide-stimulated RAW 264.7 cells
J Dairy Sci,100(9):7007-2015 2017(Sep.)
Author:Shigemori S, Namai F, Yamamoto Y, Nigar S, Sato T, Ogita T, Shimosato T


Class A CpG oligonucleotide priming rescues mice from septic shock via activation of platelet-activating factor acetylhydrolase
Frontiers in Immunology,8:1049 2017(Aug.)
Author:Yamamoto Y, Sugimura R, Watanabe T, Shigemori S, Okajima T, Nigar S, Namai F, Sato T, Ogita T, Shimosato T


Secretion of an immunoreactive single-chain variable fragment antibody against mouse interleukin 6 by Lactococcus lactis
Appl Microbiol Biotechnol,101(1):341-349 2017(Jan.)
Author:Shigemori S, Ihara M, Sato T, Yamamoto Y, Nigar S, Ogita T, Shimosato T


The use of nanoparticles to delivery immunomodulatory oligonucleotides
Wiley Interdiscip Rev Nanomed Nanobiotechnol,8(4):631-637 2016(Jul.)
Author:Klinman DM, Sato T, Shimosato T


Development of a simple IgE-independent anaphylactic model using buckwheat antigen and B-type CpG oligodeoxynucleotide from Streptococcus thermophilus
Anim Sci J,87(5):710-717 2016(May)
Author:Yamamoto Y, Shigemori S, Nigar S, Oshiro K, Wang Y, Sato T, Shimosato T


The effectiveness of sputum pH analysis in the prediction of response to therapy in patients with pulmonary tuberculosis
PeerJ,3:e1448 2015(Nov.)
Author:Masuda M, Sato T, Sakamaki K, Kudo M, Kaneko T, Ishigatsubo Y


Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice.
Microbial Cell Factories,14(1):189 2015(Nov.)
Author:Shigemori S, Watanabe T, Kudo K, Ihara M, Nigar S, Yamamoto Y, Oshiro K, Sato T, Kitazawa H, Shimosato T.


Intrapulmonary Delivery of CpG Microparticles Eliminates Lung Tumors.
Mol Cancer Ther,14(10):2198 2015(Oct.)
Author:Sato T, Shimosato T, Ueda A, Ishigatsubo Y, Klinman D


Inhibitory/suppressive oligodeoxynucleotide nanocapsules as simple oral delivery devices for preventing atopic dermatitis in mice.
Mol Ther,23(2):297 2015(Feb.)
Author:Wang Y, Yamamoto Y, Shigemori S, Watanabe T, Oshiro K, Wang X, Wang P, Sato T, Yonekura S, Tanaka S, Kitazawa H, Shimosato T


IKKα negatively regulates ASC-dependent inflammasome activation.
Nat Commun,5:4977 2014(Sep.)
Author:Martin BN, Wang C, Willette-Brown J, Herjan T, Gulen MF, Zhou H, Bulek K, Franchi L, Sato T, et al.


Generation of dipeptidyl peptidase-IV-inhibiting peptides from β-lactoglobulin secreted by Lactococcus lactis
BioMed Research International,2014:393598 2014(Aug.)
Author:Shigemori S, Oshiro K, Wang P, Yamamoto Y, Wang Y, Sato T, Uyeno Y, Shimosato T


Expression of the immunoreactive buckwheat major allergenic storage protein in Lactococcus lactis.
Appl Microbiol Biotechnol,97(8):3603 2013(Apr.)
Author:Shigemori S, Yonekura S, Sato T, Otani H, Shimosato T.


Suppressive oligodeoxynucleotides synergistically enhance antiproliferative effects of anticancer drugs in A549 human lung cancer cells.
Int J Oncol,42(2):429 2013(Feb.)
Author:Takahashi R, Sato T, Klinman DM, Shimosato T, Kaneko T, Ishigatsubo Y


Development and validation of a tuberculosis prognostic score for smear-positive in-patients in Japan
Int J Tuberc Lung Dis,17(1):54 2013(Jan.)
Author:Horita N, Miyazawa N, Yoshiyama T, Sato T, Yamamoto M, Tomaru K, Masuda M, Tashiro K, Sasaki M, Morita S, Kaneko T, Ishigatsubo Y


Serum heme oxygenase-1 as a marker of lung function decline in patients with chronic silicosis.
J Occup Environ Med,54(12):1461 2012(Dec.)
Author:Sato T, Saito Y, Inoue S, Shimosato T, Takagi S, Kaneko T, Ishigatsubo Y


Class I/II hybrid inhibitory oligodeoxynucleotide exerts Th1 and Th2 double immunosuppression.
FEBS Open Bio,3:41 2012(Nov.)
Author:Ito Y, Shigemori S, Sato T, Shimazu T, Hatano K, Otani H, Kitazawa H, Shimosato T


Synchronous lung and gastric cancers successfully treated with carboplatin and pemetrexed: a case report
J Med Case Rep,6:266 2012(Aug.)
Author:Sato T, Tomaru K, Koide T, Masuda M, Yamamoto M, Miyazawa N, Inayama Y, Kaneko T, Ishigatsubo Y


Expression of a biologically active GFP-α(S1)-casein fusion protein in Lactococcus lactis.
Curr Microbiol,64(6):569 2012(Jun.)
Author:Shigemori S, Yonekura S, Sato T, Nakanishi M, Otani H, Shimosato T.


Heterogeneity of the efficacy of the 23-valent pneumococcal polysaccharide vaccine caused by various underlying conditions of chronic pulmonary disease in older patients: prospective cohort study
BMJ Open,1(1):e000105 2011(Jul.)
Author:Inoue S, Watanuki Y, Kaneko T, Sato T, Miyazawa N, Kaneko T, Ishigatsubo Y, Morita S, Natsumeda Y, Mizushima S


The acceleration of wound healing in primates by the local administration of immunostimulatory CpG oligonucleotides.
Biomaterials,32(18):4238 2011(Jun.)
Author:Yamamoto M, Sato T, Beren J, Verthelyi D, Klinman DM


Accelerated wound healing mediated by activation of Toll-like receptor 9
Wound Repair Regen,18(6):586 2010(Nov.)
Author:Sato T, Yamamoto M, Shimosato T, Klinman DM


CpG oligodeoxynucleotides induce strong up-regulation of interleukin 33 via Toll-like receptor 9
Biochem Biophys Res Commun,394(1):81 2010(Mar.)
Author:Shimosato T, Fujimoto M, Tohno M, Sato T, Tateo M, Otani H, Kitazawa H


High frequency of β-lactamase-negative, ampicillin-resistant strains of Haemophilus influenzae in patients with chronic bronchitis in Japan
J Infect Chemother,16(1):72 2010(Feb.)
Author:Inoue S, Watanuki Y, Miyazawa N, Kudo M, Sato T, Kobayashi N, Mishina K, Sasaki M, Kaneko T, Ishigatsubo Y


Identification of a potent immunostimulatory oligodeoxynucleotide from Streptococcus thermophilus lacZ
Anim Sci J,80(5):597 2009(Oct.)
Author:Shimosato T, Tohno M, Sato T, Nishimura J, Kawai Y, Saito T, Kitazawa H


Therapeutic applications and mechanisms underlying the activity of immunosuppressive oligonucleotides
Ann N Y Acad Sci,1175:80 2009(Sep.)
Author:Klinman DM, Tross D, Klaschik S, Shirota H, Sato T


CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases
Adv Drug Deliv Rev,61(3):248 2009(Mar.)
Author:Klinman DM, Klaschik S, Sato T, Tross D


Synthetic oligonucleotides as modulators of inflammation
J Leukoc Biol,84(4):958 2008(Oct.)
Author:Klinman D, Shirota H, Tross D, Sato T, Klaschik S


Suppressive oligodeoxynucleotides inhibit silica-induced pulmonary inflammation
J Immunol,180(11):7648 2008(Jun.)
Author:Sato T, Shimosato T, Alvord WG, Klinman DM


Heme oxygenase-1, a potential biomarker of chronic silicosis, attenuates silica-induced lung injury
Am J Respir Crit Care Med,174(8):906 2006(Oct.)
Author:Sato T, Takeno M, Honma K, Yamauchi H, Saito Y, Sasaki T, Morikubo H, Nagashima Y, Takagi S, Yamanaka K, Kaneko T, Ishigatsubo Y


Heme oxygenase-1 inhibits cigarette smoke-induced increase in the tracheal mucosal permeability in guinea pigs in vivo
Inflamm Res,54(5):229 2005(May)
Author:Tagawa A, Kaneko T, Shinohara T, Ueda A, Sato T, Ishigatsubo Y


Cigarette smoke increases mucosal permeability in guinea pig trachea via tachykinin NK2 receptor activation
Eur J Pharmacol,507(1-3):223 2005(Jan.)
Author:Tagawa A, Kaneko T, Nishiyama H, Shinohara T, Sato T, Geppetti P, Ishigatsubo Y


講演・口頭発表等
Innovative therapy for lung cancer ~Intratracheal delivery of nanomicroparticles-incorporated immune checkpoint-blocking single-chain variable fragment~
NIH/NCI Symposium on Innate Immunity & Modulation of the Host Immune Response in Honor of the Career of Dr. Dennis Klinman 2019(Jun. 27)
Presenter:SATO Takashi


吸入治療イノベーション~吸入薬で肺癌の制御を目指す研究開発の取り組み~
横浜市立大学先端医科学研究センター 第54回市民講座 2018(Oct. 30)
Presenter:佐藤 隆

特許等知的財産
登録済特許
Polyketal particles including a CpG oligodeoxynucleotide for the treatment of lung cancer
Method of treating pneumoconiosis with oligodeoxynucleotides
Use of CpG oligodeoxynucleotides to induce epithelial cell growth
研究費
科学研究費補助金(研究代表者)
2019 - 2022 , 免疫チェックポイント阻害乳酸菌による肺癌発癌予防・進展予防効果の検証 , 国際共同研究加速基金(国際共同研究強化(B))
2018 - 2019 , 吸入療法イノベーションの実現:高分子・抗体医薬の経気道投与による肺癌治療戦略 , 挑戦的研究(萌芽)
2015 - 2017 , ナノ粒子化免疫調節剤の呼吸器疾患への治療応用の研究 , 基盤C
2011 - 2012 , 微生物由来 DNA を利用した吸入型炎症性肺疾患治療薬の開発 , 若手B
2009 - 2010 , 免疫調節性DNAとナノ・マイクロ粒子キャリアーを用いた吸入型DNA治療薬の開発 , 若手B

科学研究費補助金(研究分担者)
2017 - 2020 , 乳酸菌オリゴDNAを有効成分とする経口用ナノカプセルを用いた免疫調節機構の解明 , 基盤B

その他公的資金
2017 - 2019 , 日本医療研究開発機構(AMED)・創薬基盤推進研究事業・Fine Droplet Dryingテクノロジーによる経気道治療用ナノマイクロ粒子包埋医薬品の創出を目指した研究
2017 - 2019 , ライフイノベーションプラットフォーム横浜推進プロジェクト・圧電素子を用いた経気道投与用パーソナル吸入デバイスの開発研究