Oral cyclophosphamide was effective for Coombs-negative autoimmune hemolytic anemia in CD16+CD56-chronic lymphoproliferative disorder of NK-cells INTERNATIONAL JOURNAL OF HEMATOLOGY,105(6):854-858 2017(Jun.) Author:Sekiguchi, Nodoka; Nishina, Sayaka; Kawakami, Toru; Sakai, Hitoshi; Senoo, Noriko; Senoo, Yasushi; Ito, Toshiro; Saito, Hiroshi; Nakazawa, Hideyuki; Koizumi, Tomonobu; Ishida, Fumihiro;
A screening method with lymphocyte percentage and proportion of granular lymphocytes in the peripheral blood for large granular lymphocyte (LGL) leukemia INTERNATIONAL JOURNAL OF HEMATOLOGY,105(1):87-91 2017(Jan.) Author:Tanahashi, Takahiro; Sekiguchi, Nodoka; Matsuda, Kazuyuki; Matsumoto, Akihiro; Ito, Toshiro; Nakazawa, Hideyuki; Ishida, Fumihiro;
Cell size variations of large granular lymphocyte leukemia: Implication of a small cell subtype of granular lymphocyte leukemia with STAT3 mutations LEUKEMIA RESEARCH,45:8-13 2016(Jun.) Author:Tanahashi, Takahiro; Sekiguchi, Nodoka; Matsuda, Kazuyuki; Takezawa, Yuka; Ito, Toshiro; Kobayashi, Hikaru; Ichikawa, Naoaki; Nishina, Sayaka; Senoo, Noriko; Sakai, Hitoshi; Nakazawa, Hideyuki; Ishida, Fumihiro;
A prognostic index for natural killer cell lymphoma after non-anthracycline-based treatment: a multicentre, retrospective analysis LANCET ONCOLOGY,17(3):389-400 2016(Mar.) Author:Kim, Seok Jin; Yoon, Dok Hyun; Jaccard, Arnaud; Chng, Wee Joo; Lim, Soon Thye; Hong, Huangming; Park, Yong; Chang, Kian Meng; Maeda, Yoshinobu; Ishida, Fumihiro; Shin, Dong-Yeop; Kim, Jin Seok; Jeong, Seong Hyun; Yang, Deok-Hwan; Jo, Jae-Cheol; Lee, Gyeong-Won; Choi, Chul Won; Lee, Won-Sik; Chen, Tsai-Yun; Kim, Kiyeun; Jung, Sin-Ho; Murayama, Tohru; Oki, Yasuhiro; Advani, Ranjana; d'Amore, Francesco; Schmitz, Norbert; Suh, Cheolwon; Suzuki, Ritsuro; Kwong, Yok Lam; Lin, Tong-Yu; Kim, Won Seog;
NK細胞腫瘍の診断と治療における最近の進歩 (第76回日本血液学会学術集会) -- (Symposium : Advances in the treatment of NK-cell malignancies) 臨床血液,56(6):645-650 2015(Jun.) Author:石田 文宏; Keywords:Mature NK cell neoplasm; L-asparaginase; Hematopoietic stem cell transplantation; Epstein-Barr virus;
LGL白血病のSTAT3遺伝子変異と併発する赤芽球癆 血液内科,70(1):93-96 2015(Jan.) Author:石田 文宏; 関口 和; Keywords:LGL leukemia; cytotoxic T cell; NK cell; STAT3; pure red cell aplasia;
Prognostic significance of pleural or pericardial effusion and the implication of optimal treatment in primary mediastinal large B-cell lymphoma: a multicenter retrospective study in Japan HAEMATOLOGICA,99(12):1817-1825 2014(Dec.) Author:Aoki, Tomohiro; Izutsu, Koji; Suzuki, Ritsuro; Nakaseko, Chiaki; Arima, Hiroshi; Shimada, Kazuyuki; Tomita, Akihiro; Sasaki, Makoto; Takizawa, Jun; Mitani, Kinuko; Igarashi, Tadahiko; Maeda, Yoshinobu; Fukuhara, Noriko; Ishida, Fumihiro; Niitsu, Nozomi; Ohmachi, Ken; Takasaki, Hirotaka; Nakamura, Naoya; Kinoshita, Tomohiro; Nakamura, Shigeo; Ogura, Michinori;
STAT3 gene mutations and their association with pure red cell aplasia in large granular lymphocyte leukemia CANCER SCIENCE,105(3):342-346 2014(Mar.) Author:Ishida, F; Matsuda, K; Sekiguchi, N; Makishima, H; Taira, C; Momose, K; Nishina, S; Senoo, N; Sakai, H; Ito, T; Kwong, YL
Screening Tests Using Serum Tissue Transglutaminase IgA May Facilitate the Identification of Undiagnosed Celiac Disease among Japanese Population INTERNATIONAL JOURNAL OF MEDICAL SCIENCES,11(8):819-823 2014 Author:Nakazawa, Hideyuki; Makishima, Hideki; Ito, Toshiro; Ota, Hiroyoshi; Momose, Kayoko; Sekiguchi, Nodoka; Yoshizawa, Kaname; Akamatsu, Taiji; Ishida, Fumihiro;
Large vessel vasculitis developed early after allogeneic bone marrow transplant for acute erythroid leukemia LEUKEMIA & LYMPHOMA,54(12):2748-2749 2013(Dec.) Author:Kawakami, Toru; Ito, Toshiro; Sakai, Hitoshi; Sekiguchi, Nodoka; Nakazawa, Hideyuki; Senoo, Noriko; Nishina, Sayaka; Ishida, Fumihiro;
Liver Dysfunction and Thrombocytopenia Diagnosed as Intravascular Large B-cell Lymphoma Using a Timely and Accurate Transjugular Liver Biopsy INTERNAL MEDICINE,52(17):1903-1908 2013 Author:Sekiguchi, N; Joshita, S; Yoshida, T; Kurozumi, M; Sano, K; Nakagawa, M; Ito, T; Matsushita, T; Komatsu, D; Komatsu, M; Ito, T; Umemura, T; Ikeda, S; Kadoya, M; Ishida, F; Tanaka, E
Splicesome-related gene mutations in myelodysplastic syndrome can be used as stable markers for monitoring minimal residual disease during follow-up Leukemia Res 2012 Author:Matsuda K, Ishida F, Ito T, Nakazawa H, Miura S, Taira C, Sueki A, Kobayashi Y, Honda T
Aggressive NK-cell leukemia: Therapeutic potentialsof L-asparaginase and allogeneic hematopoietic stem cell transplantation. Cancer Science,103(6):1079-83 2012 Author:Ishida, F, Ko, Y H, Kim, W S, Suzumiya J, Isobe Y, Oshimi K, Nakamura S, Suzuki R
Donor lymphocyte infusion for extranodal NK/T cell lymphoma, nasal type, relapsed after allogeneic hematopoietic stem cell transplantation Bone Marrow Transplantation.,46:1270-71 2011 Author:Ito T, Makishima H, Nakazawa H, Senoo Y, Senoo N, Ishida F.
Phase II study of SMILE chemotherapy for newly-diagnosed stage IV, relapsed or refractory extranodal NK/T-cell lymphoma, nasal type: the NK-cell Tumor Study Group (NKTSG) study. J Clin Oncol,29:4410-4416 2011 Author:Yamaguchi M, Kwong YL, Kim, WS, Maeda Y, Hashimoto C, Suh C, Izutu K, Ishida F, Isobe Y, Sueoka E, Suzumiya J, Kodama T, Kimura H, Hyo R Nakamura S, Oshimi K, Suzuki R
Quantitative monitoring of single nucleotidemutations by allele-specific quantitative PCR can be used for the assessment of minimal residual disease in patients with hematological malignancies throughout their clinical cours Clinica Chimica Acta,412:53-8 2011 Author:Taira C, Matsuda K, Kamijyo Y, Sakashita K, Ishida F, Kumagai T, Yamauchi K, Okumura N, Honda T
A C-terminal amino acid substitution in the gamma-chain caused by a novel heterozygous frameshift mutation (Fibrinogen Matsumoto VII) results in hypofibrinogenaemia THROMBOSIS AND HAEMOSTASIS,104(2):213-223 2010(Aug.) Author:Fujihara, Noriko; Haneishi, Ayumi; Yamauchi, Kazuyoshi; Terasawa, Fumiko; Ito, Toshiro; Ishida, Fumihiro; Okumura, Nobuo
Late relapse of extranodal natural killer/T cell lymphoma, nasal type, after more than ten years LEUKEMIA&LYMPHOMA,51(1):171-173 2010(Jan.) Author:Ishida, Fumihiro; Nishina, Sayaka; Asano, Naoko; Sasaki, Shigeru; Sekiguchi, Nodoka; Nakazawa, Hideyuki; Ito, Toshiro; Shikama, Naoto
The diagnosis and management of natural killer cell malignancies. Expert Review of Hematology,3:593-602 2010 Author:Ishida F, Kwong YL
Spontaneous regression of the inhibitor against the coagulation factor XIII A subunit in acquired factor XIII deficiency Thromb and Haemost,104:1284-5 2010 Author:Ishida F. Okubo K, Ito T, Okumura N, Souri M, Ichinose A
Age-ralated Epstein-Barr virus(EBV) associated B-cell lymphoproliferative disorders:comparison with EBV-positive classic Hodgkin lymphoma in elderly patients BLOOD,113:2629-2636 2009 Author:Asano N, Yamamoto K, Tamaru J, Oyama T, Ishida F, Oshima K, Yoshino T, Nakumara N, Mori S, Yoshie O,Shimoyama Y, Morishima Y, Kinoshita T, Nakamura S
Promising approach for aggressive NK cell leukaemia with allogeneic haematopoietic cell transplantation Eur J Haemat,81:107-111 2008 Author:Ito T, Makishima H, Nakazawa H, Kobayashi H, Shimodaira S, Nakazawa Y, Kitano K, Matsuda K, Hidaka E, Ishida F
Chemokine system and tissue infiltration in aggressive NK-cell leukemia. Leukemia Res,31:1245-1253 2007 Author:Makishima H, Ito T, Momose K, Nakazawa H, Shimodaira S, Kamijo Y, Nakazawa Y, Ichikawa N, Ueno M, Kobayashi H, Kitano K, Saito H, Kiyosawa K, Ishida F.
Prognostic significance of T-cell or cytotoxic molecules phenotype in classical Hodgkin’s lymphoma: a clinicopathologic study J Clin Oncol,24:2646-2633 2006 Author:Asano N, Oshiro A, Matsuo K, Kagami Y, Ishida F, Suzuki R, Kinoshita T, Shimoyama Y, Tamaru J, Yoshino T, Kitamura K, Fukutani H, Morishima Y, Nakamura S.
Intestinal diffuse large B cell lymphoma associated with celiac disease -a Japanesecase Int J Hematol,83(1):63-65 2006 Author:Makishima H, Ito T, Kodama R, Asano N, Nakazawa H, Hirabayashi K, Nakamura S, Ota M, Akamatsu T, Kiyosawa K, Ishida F.
Prognostic significance of T-cell or cytotoxic molecules phenotype in classical Hodgkin's lymphoma: A clinicopathologic study JOURNAL OF CLINICAL ONCOLOGY,24(28):4626-4633 2006 Author:Asano, N; Oshiro, A; Matsuo, K; Kagami, Y; Ishida, F; Suzuki, R; Kinoshita, T; Shimoyama, Y; Tamaru, JI; Yoshino, T; Kitamura, K; Fukutani, H; Morishima, Y; Nakamura, S
Thrombotic thrombocytopenic purpura associated with pegylated-interferon alpha-2a by an ADAMTS13 inhibitor in a patient with chronic hepatitis C Haematologica,91:ECR34 2006 Author:Kitano K, Gibo Y, Kamijo A, Furuta K, Oguchi S, Joshita S, Takahashi Y, Ishida F, Matsumoto M, Uemura M, Fujimura Y
A case of acute myelogenous leukemia with MLL-AF10 fusion caused by insertion of 5’ MLL into 10p12, with concurrent 3’ MLL deletion Cancer Genet Cytogenet,171(1):24-30 2006 Author:Matsuda K, Hidaka E, Ishida F, Yamauchia K, Makishima H, Ito T, Suzuki T, Imagawa E, Sano K, Katsuyama T, Ota H
Adenovirus fulminant hepatic failure after unrelated allogeneic stem cell transplantation for acute lymphoblastic leukemia Internal Med,4:975-980 2006 Author:Nakazawa H, Ito T, Makishima H, Misawa N, Okiyama W, Uehara T, Hidaka E, Kiyosawa K, Ishida F
Significance of chemokine receptor expression in aggressive NK cell leukemia Leukemia,19(7):1169-1174 2005 Author:Makishima H, Ito T, Asano N, Nakazawa H, Shimodaira S, Kamijo Y, Nakazawa Y, Suzuki T, Kobayashi H, Kiyosawa K, Ishida F
Clinicopathologic and prognostic significance of cytotoxic molecule expression in nodal peripheral T-cell lymphoma, unspecified Am J Surg Pathol,29(10):1284-1293 2005 Author:Asano N, Suzuki R, Kagami Y, Ishida F, Kitamura K, Fukutani H, Morishima Y, Takeuchi K,Nakamura S
Ribavirin-induced pure red-cell aplasia during treatment of chronic hepatitis C N Engl J Med,350(12):1264-1265 2004 Author:Tanaka .N, Ishida F, Tanaka E
DNA microarray analysis of natural kller cell-type lymphoproliferative disease of granular lymphocytes with purified CD3-CD56+ fractions Leukemia,18(3):556-565 2004 Author:Choi YL, Makishima H, Ohashi J, Yamashita Y, Ohki R, Koinuma K, Ota J, Isobe Y, Ishida F, Oshimi K, Mano H
Idiopathic myelofibrosis with refractory massive ascites Intern Med,42(6):525-528 2003 Author:Yotsumoto M, Ishida F, Ito T, Ueno M, Kitano K, Kiyosawa K
Lymphoproliferative disease of granular lymphocytes with T-cell receptor gamma delta-positive phenotype: restricted usage of T-cell receptor gamma and delta subunit genes Eur J Haematol,70(4):212-218 2003 Author:Makishima H, Ishida F, Saito H, Ichikawa N, Ozaki Y, Ito S, Ota M, Katsuyama Y, Kiyosawa K
Human factor VII deficiency caused by S339C mutation located adjacent to the specificity pocket of the catalytic domain Clin Lab Haematol,24(4):233-238 2002 Author:Takamiya O, Seta M, Tanaka K, Ishida F
DNA microarray analysis of T cell-type lymphoproliferative disease of granular lymphocytes Br J Haematol,118(2):462-469 2002 Author:Makishima H, Ishida F, Ito T, Kitano K, Ueno S, Ohmine K, Yamashita Y, Ota J, Ota M, Yamauchi K, Mano H
t (8;21;14) (q22;q22;q24) is a novel variant of t (8;21) with chimeric transcripts of AML1-ETO in acute myelogenous leukemia Cancer Genet Cytogenet,132(2):133-135 2002 Author:Ishida F, Ueno M, Tanaka H, Makishima H, Suzawa K, Hosaka S, Hidaka E, Ishikawa M, YamauchiK, Kitano K, Kiyosawa K
Fibrinogen Matsumoto V: a variant with a alpha 19 Arg ->Gly (AGG ->GGG) - Comparison between fibrin polymerization stimulated by thrombin or reptilase and fibrin monomer polymerization THROMBOSIS AND HAEMOSTASIS,85(1):108-113 2001 Author:Tanaka, H; Terasawa, F; Ito, T; Tokunaga, S; Ishida, F; Kitano, K; Kiyosawa, K; Okumura, N
Abnormal proliferation of CD4(-) CD8(+) gamma delta(+) T cells with chromosome 6 anomaly: Role of fas ligand expression in spontaneous regression of the cells AMERICAN JOURNAL OF HEMATOLOGY,60(4):305-308 1999 Author:Ichikawa, N; Kitano, K; Ito, T; Nakazawa, T; Shimodaira, S; Ishida, F; Kiyosawa, K
Fibrinogen Matsumoto III: a variant with gamma 275 Arg ->Cys (CGC ->TGC) - Comparison of fibrin polymerization properties with those of Matsumoto I (gamma 364 Asp ->His) and Matsumoto II (gamma 308 Asn ->Lys) THROMBOSIS AND HAEMOSTASIS,81(5):763-766 1999 Author:Terasawa, F; Okumura, N; Higuchi, Y; Ishikawa, S; Tozuka, M; Ishida, F; Kitano, K; Katsuyama, T
Hairy cell leukemia with translocation (11;20)(q13;q11) and overexpression of cyclin D1 LEUKEMIA RESEARCH,23(8):763-765 1999 Author:Ishida, F; Kitano, K; Ichikawa, N; Ito, T; Kohara, Y; Taniguchi, T; Motokura, T; Kiyosawa, K
Elliptocytosis in myelodysplastic syndrome associated with translocation (1;5)(p10;q10) and deletion of 20q Cancer Genet Cytogenet,108(2):162-165 1999 Author:Ishida, F; Shimodaira, S; Kobayashi, H; Saito, H; Kako, M; Kanzaki, A; Yawata, Y; Kitano, K; Kiyosawa, K
Cold agglutinin disease by autoanti-i blood type antibody associated with B cell chronic lymphocytic leukemia INTERNATIONAL JOURNAL OF HEMATOLOGY,67(1):69-73 1998 Author:Ishida, F; Saito, H; Kitano, K; Kiyosawa, K
Associations between polymorphism of platelet membrane glycoprotein Ib alpha, plasma von Willebrand factor antigen and coronary artery disease. BLOOD,92(10):191A-191A 1998 Author:Ito, T; Ishida, F; Shimodaira, S; Takei, M; Kitano, K; Kiyosawa, K
東アジアにおけるAPCレジスタンス測定の意義 臨床血液 = The Japanese Journal of Clinical Hematology,38(4):316-318 1997(Apr. 30) Author:石田 文宏; 高宮 脩; Keywords:APC resistance; Factor V; easten Asia;
Resistance to activated protein C and Arg 506 Gln factor V mutation are uncommon in eastern Asian populations ACTA HAEMATOLOGICA,98(1):22-25 1997 Author:Kodaira, H; Ishida, F; Shimodaira, S; Takamiya, O; Furihata, K; Kitano, K
Eosinophilia associated with clonal T-cell proliferation LEUKEMIA&LYMPHOMA,27(3-4):335-342 1997 Author:Kitano, K; Ichikawa, N; Shimodaira, S; Ito, T; Ishida, F; Kiyosawa, K
Elevated IgG4 levels in a case with multicentric Castleman's disease BRITISH JOURNAL OF HAEMATOLOGY,99(4):981-982 1997 Author:Ishida, F; Kitano, K; Kobayashi, H; Saito, H; Kiyosawa, K
Eosinophilia associated with proliferation of CD3(+)4(-)8(-) alpha beta(+) T cells with chromosome 16 anomalies BRITISH JOURNAL OF HAEMATOLOGY,92(2):315-317 1996 Author:Kitano, K; Ichikawa, N; Mahbub, B; Ueno, M; Ito, T; Shimodaira, S; Kodaira, H; Ishida, F; Kobayashi, H; Saito, H; Okubo, Y; Enokihara, H; Kiyosawa, K
Serum thrombopoietin (c-mpl ligand) levels in patients with liver cirrhosis BRITISH JOURNAL OF HAEMATOLOGY,93:1033-1033 1996 Author:Kitano, K; Shimodaira, S; Ishida, F; Ichikawa, N; Kodaira, H; Ito, T; Tahara, T; Kato, T; Kiyosawa, K
Regulation of serum thrombopoietin levels by platelets and megakaryocytes in patients with aplastic anemia and idiopathic thrombocytopenic purpura. EXPERIMENTAL HEMATOLOGY,24(9):428-428 1996 Author:Ichikawa, N; Ishida, F; Shimodaira, S; Ito, T; Tahara, T; Kato, T; Kitano, K
Serum thrombopoietin (c-Mpl ligand) levels in patients with liver cirrhosis THROMBOSIS AND HAEMOSTASIS,76(4):545-548 1996 Author:Shimodaira, S; Ishida, F; Ichikawa, N; Tahara, T; Kato, T; Kodaira, H; Ito, T; Tanaka, E; Sodeyama, T; Kiyosawa, K; Kitano, K
The largest isoform of platelet membrane glycoprotein Ib?lpha is commonly distributed in eastern Asian populations Thromb Haemost,76:245-247 1996 Author:Ishida F/ Furihata K
Regulation of serum thrombopoietin levels by platelets and megakaryocytes in patients with aplastic anaemia and idiopathic thrombocytopenic purpura Thromb Haemost,76(2):156-160 1996 Author:Ichikawa N/ Ishida F
Serum thrombopoietin(C-Mpl ligand) levels in patients with liver cirrhosis Thromb Haemost,76:545-548 1996 Author:Shimodaira S/ Ishida F
血小板膜糖蛋白 (GP) Ibαの多型 日本血栓止血学会誌 = The Journal of Japanese Society on Thrombosis and Hemostasis,6(6):442-452 1995(Dec. 01) Author:石田 文宏; 降旗 謙一; Keywords:glycoprotein Ibα; polymorphism; HPA-2; tandem repeat; linkage disequilibrium;
THE DETECTION OF CLONAL PROLIFERATION IN GRANULAR LYMPHOCYTE-PROLIFERATIVE DISORDERS OF NATURAL-KILLER-CELL LINEAGE BRITISH JOURNAL OF HAEMATOLOGY,90(3):578-584 1995 Author:SHIMODAIRA, S; ISHIDA, F; KOBAYASHI, H; MAHBUB, B; KAWAHA, K; KITANO, K
THE LARGEST VARIANT OF PLATELET GLYCOPROTEIN IB-ALPHA HAS 4 TANDEM REPEATS OF 13 AMINO-ACIDS IN THE MACROGLYCOPEPTIDE REGION AND A GENETIC-LINKAGE WITH METHIONINE BLOOD,86(4):1356-1360 1995 Author:ISHIDA, F; FURIHATA, K; ISHIDA, K; YAN, J; KITANO, K; KIYOSAWA, K; FURUTA, S
APC-RESISTANCE AND MNL-I GENOTYPE (GLN-506) OF COAGULATION-FACTOR-V ARE RARE IN JAPANESE POPULATION THROMBOSIS AND HAEMOSTASIS,74(3):996-996 1995 Author:TAKAMIYA, O; ISHIDA, F; KODAIRA, H; KITANO, K
Arg 506 Gln factor V mutation is uncommon in eastern Asian populations. BLOOD,86(10):3658-3658 1995 Author:Kodaira, H; Ishida, F; Ito, T; Ichikawa, N; Shimofaira, S; Takamiya, O; Furihata, K; Kiyosawa, K; Kitano, K
TRANSFUSION-ASSOCIATED GRAFT-VERSUS-HOST DISEASE IN AN IMMUNOCOMPETENT PATIENT FOLLOWING ACCIDENTAL INJURY AMERICAN JOURNAL OF HEMATOLOGY,43(1):51-53 1993 Author:KOBAYASHI, H; KITANO, K; KISHI, E; HARA, K; ISHIDA, F; SAITO, H; OTA, M; FURUTA, S
EOSINOPHILIA IN MYELODYSPLASTIC SYNDROME WITH A (12 21)(Q23 Q22) TRANSLOCATION CANCER GENETICS AND CYTOGENETICS,68(2):95-98 1993 Author:KOBAYASHI, H; KITANO, K; SHIMODAIRA, S; ISHIDA, F; SAITO, H; SONOYAMA, M; ENOKIHARA, H; FURUTA, S
APLASTIC-ANEMIA AND IDIOPATHIC THROMBOCYTOPENIC PURPURA WITH ANTIBODY TO PLATELET GLYCOPROTEIN IIB/IIIA FOLLOWING RESECTION OF MALIGNANT THYMOMA ACTA HAEMATOLOGICA,90(1):42-45 1993 Author:KOBAYASHI, H; KITANO, K; ISHIDA, F; SAITO, H; MIYABAYASHI, H; YONEZAWA, T; INADA, H; SUZUKI, A; FURUTA, S
GENETIC AND STRUCTURAL CHARACTERIZATION OF AN AMINO-ACID DIMORPHISM IN GLYCOPROTEIN IB-ALPHA INVOLVED IN PLATELET TRANSFUSION REFRACTORINESS BLOOD,79(11):3086-3090 1992 Author:MURATA, M; FURIHATA, K; ISHIDA, F; RUSSELL, SR; WARE, J; RUGGERI, ZM
HUMAN PLATELET-SPECIFIC ANTIGEN, SIBA, IS ASSOCIATED WITH A STRUCTURAL POLYMORPHISM OF GLYCOPROTEIN IB-ALPHA THROMBOSIS AND HAEMOSTASIS,65(6):796-796 1991 Author:ISHIDA, F; SAJI, H; MARUYA, E; FURUTA, S; FURIHATA, K
HUMAN PLATELET-SPECIFIC ANTIGEN, SIB(A), IS ASSOCIATED WITH THE MOLECULAR-WEIGHT POLYMORPHISM OF GLYCOPROTEIN-IB-ALPHA BLOOD,78(7):1722-1729 1991 Author:ISHIDA, F; SAJI, H; MARUYA, E; FURIHATA, K
Ｍｏｄｉｆｉｅｄ ａｎｔｉｇｅｎ‐ｃａｐｔｕｒｅ ＥＬＩＳＡによる血小板同種抗原Ｂｒ｀ａ´／Ｂｒ｀ｂ´の検出 日本輸血学会雑誌,36(6):713-716 1990 Author:石田 文宏; 緒方 洪之; 古田 精市; 降旗 謙一; Abstract:A platelet alloantigen system, Bra/Brb, is defined recently and is implicated in several cases of neonatal alloimmune thrombocytopenic purpura (NATP) in Europe. Since each platelet has only 1, 000-2, 000 molecules of BraBrb antigens, it is very hard to phenotype platelets by methods in which whole platelets are used as antigens. In this study, we employed modified antigen-capture ELISA (MACE) to phenotype platelets for Bra/Brb. Platelets were easily phenotyped qualitatively and semiquantitatively by MACE in which a murine monoclonal anti-glycoprotein (GP) IIa (4B4; CD29) was used to capture GP Ia-IIa complex. Phenotypic frequencies of Bra and Brb among 67 Japanese were 11.7% and over 98.3%, respectively. Their frequencies among Japanese were significantly differed from those among Caucasians and chilean Indians. Bra/Brb antigen system would be responsible for some cases of NATP and platelet transfusion refractoriness in Japan. MACE would be extremely useful to identify Bra/Brb incompatibility in those cases.
IL-2添加による染色体分析で47XY, +8の異常を認めたnatural killer細胞型granular lymphocyte leukemia 臨床血液,31(10):1711-1715 1990 Author:石田 文宏; 斉藤 博; 降旗 謙一; 古田 精市; 園山 政行; 押味 和夫; Abstract:A 28-year-old male was admitted to our hospital because of hepatosplenomegaly and granular lymphocytosis. His peripheral leukocyte count was 3,000/μl with 43% of granular lymphocytes (GL). These GLs were immunologically phenotyped as CD2+CD3-CD4-CD8-CD16+CD56+HLA-DR+ and were found that TcR genes coding beta and gamma chains were not rearranged. Chromosomal analysis of his GLs stimulated with IL-2 showed 47 XY, +8. This patient was diagnosed as a granular lymphocyte leukemia of natural killer cell type. Blood chemistry showed elevation of serum GOT, GPT and LDH values. The fever persisted until administration of prednisolone was initiated. But 40 days after, high fever appeared again and the liver and spleen were extremely enlarged. Combined chemotherapy was then started but resulted in no effects. He died of hepatic failure on the 77th day from admission. 47 XY, +8, that has been reported in acute non-lymphocytic leukemia and myelodysplastic syndrome, may be related to the pathogenesis in some cases of granular lymphocyte leukemia. Keywords:granular lymphocyte leukemia; natural killer cell; 47 XY; +8;
A Missense Mutation (Tyr88 to Cys) in the Platelet Membrane Glycoprotein Ib?eta gene affects the expression of GPIb/IX complex expression Thromb Haemost Author:Kurokawa Y/ Ishida F
研究者総覧
