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小林 法元  コバヤシ ノリモト

教員組織電話番号0263-37-2642
教育組織医学部 医学科 小児医学FAX番号0263-37-3089
職名特任准教授メールアドレス
住所〒390-8621 長野県松本市旭3-1-1ホームページURL

更新日:2021/07/19

プロフィール

COE・クラスタ・
研究グループ
小児免疫 , 小児リウマチ・膠原病
研究分野
膠原病・アレルギー内科学
所属学会
所属学会
日本小児科学会
日本リウマチ学会
日本小児リウマチ学会
日本アレルギー学会
学歴
取得学位
医学博士 , 信州大学(日本)

研究活動業績

研究業績(著書・
発表論文等)
論文
Analysis of serum IL-38 in juvenile-onset systemic lupus erythematosus. Agematsu K.
Mod Rheumatol. 2018
Author:Takeuchi Y, Seki T, Kobayashi N, Sano K, Shigemura T, Shimojo H, Matsumoto K, Agematsu K.


Heterozygous Mutations in OAS1 Cause Infantile-Onset Pulmonary Alveolar Proteinosis with Hypogammaglobulinemia.
Am J Hum Genet.,102(3):480 2018
Author:Cho K, Yamada M, Agematsu K, Kanegane H, Miyake N, Ueki M, Akimoto T, Kobayashi N, Ikemoto S, Tanino M, Fujita A, Hayasaka I, Miyamoto S, Tanaka-Kubota M, Nakata K, Shiina M, Ogata K, Minakami H, Matsumoto N, Ariga T.


A Pediatric Case of Relapsing-Remitting Multiple Sclerosis Onset following Varicella Zoster Ophthalmicus with Optic Neuritis.
Case Rep Pediatr 2018
Author:Shiba N, Inaba Y, Motobayashi M, Nishioka M, Kawasaki Y, Noda S, Matsuura H, Kobayashi N, Matsuoka T, Nakamura A, Nakazawa Y.


Characteristics and outcome of intractable vasculitis syndrome in children: Nation-wide survey in Japan.
,28(4):697 2018
Author:Nakano N, Mori M, Umebayashi H, Iwata N, Kobayashi N, Masunaga K, Imagawa T, Murata T, Kinjo N, Nagai K, Miyoshi M, Takei S, Yokota S, Ishii E.


Analysis of biomarker serum levels in IVIG and infliximab refractory Kawasaki disease patients.
Clin Rheumatol.,37(7):1937 2018
Author:Hachiya A, Kobayashi N, Matsuzaki S, Takeuchi Y, Akazawa Y, Shigemura T, Motoki N, Masumoto J, Agematsu K.


Infliximab versus intravenous immunoglobulin for refractory Kawasaki disease: a phase 3, randomized, open-label, active-controlled, parallel-group, multicenter trial.
Sci Rep.,8(1) 2018
Author:Mori M, Hara T, Kikuchi M, Shimizu H, Miyamoto T, Iwashima S, Oonishi T, Hashimoto K, Kobayashi N, Waki K, Suzuki Y, Otsubo Y, Yamada H, Ishikawa C, Kato T, Fuse S.


IFR4/MUM1-positive lymphoma in Waldeyer ring with co-expression of CD5 and CD10.
Pediatr Blood Cancer.,64(2):311 2017
Author:Chen L, Al-Kzayer LF, Liu T, Kobayashi N, Nakazawa Y, Koike K.


Acute Myeloid Leukemia in a Patient With X-linked Severe Combined Immunodeficiency.
J Pediatr Hematol Oncol. 2017
Author:Shigemura T, Motobayashi M, Matsuda K, Shimodaira T, Kurata T, Kobayashi N, Agematsu K, Nakazawa Y.


Early diagnosis of early-onset sarcoidosis: a case report with functional analysis and review of the literature.
Clin Rheumatol.,36(5):1189 2017
Author:Takeuchi Y, Shigemura T, Kobayashi N, Kaneko N, Iwasaki T, Minami K, Kobayashi K, Masumoto J, Agematsu K.


IFR4/MUM1-positive lymphoma in Waldeyer ring with co-expression of CD5 and CD10.
Pediatr Blood Cancer,64(2):311 2017
Author:Chen L, Al-Kzayer LF, Liu T, Kobayashi N, Nakazawa Y, Koike K.


Markedly elevated CD64 expression on neutrophils and monocytes as a biomarker for diagnosis and therapy assessment in Kawasaki disease
INFLAMMATION RESEARCH,65(7):579-585 2016(Jul.)
Author:Hokibara, Sho; Kobayashi, Norimoto; Kobayashi, Keiko; Shigemura, Tomonari; Nagumo, Haruo; Takizawa, Masahiro; Yamazaki, Takashi; Agematsu, Kazunaga;


Immune Complex-Mediated Glomerulonephritis in a Patient with Wiskott-Aldrich Syndrome
JOURNAL OF CLINICAL IMMUNOLOGY,36(4):357-359 2016(May)
Author:Shigemura, Tomonari; Nakazawa, Yozo; Shimojo, Hisashi; Kobayashi, Norimoto; Agematsu, Kazunaga;


A novel surfactant protein C L55F mutation associated with interstitial lung disease alters subcellular localization of proSP-C in A549 cells
PEDIATRIC RESEARCH,79(1):27-33 2016(Jan.)
Author:Liu, Tingting; Sano, Kenji; Ogiwara, Naoko; Kobayashi, Norimoto;


Novel heterozygous C243Y A20/TNFAIP3 gene mutation is responsible for chronic inflammation in autosomal-dominant Behçet's disease.
RMD open,2(1) 2016
Author:Shigemura T, Kaneko N, Kobayashi N, Kobayashi K, Takeuchi Y, Nakano N, Masumoto J, Agematsu K.


IL-18 serum concentration is markedly elevated in typical familial Mediterranean fever with M694I mutation and can distinguish it from atypical type
MODERN RHEUMATOLOGY,26(2):315-317 2016
Author:Yamazaki, Takashi; Shigemura, Tomonari; Kobayashi, Norimoto; Honda, Kimiko; Yazaki, Masahide; Masumoto, Junya; Migita, Kiyoshi; Agematsu, Kazunaga;


Increased Serum B Cell Activating Factor and a Proliferation-inducing Ligand Are Associated with Interstitial Lung Disease in Patients with Juvenile Dermatomyositis
JOURNAL OF RHEUMATOLOGY,42(12):2412-2418 2015(Dec.)
Author:Kobayashi, Norimoto; Kobayashi, Ichiro; Mori, Masaaki; Sato, Shinji; Iwata, Naomi; Shigemura, Tomonari; Agematsu, Kazunaga; Yokota, Shumpei; Koike, Kenichi;


Cytomegalovirus Encephalitis in a Patient with Severe Combined Immunodeficiency
JOURNAL OF CLINICAL IMMUNOLOGY,35(8):689-691 2015(Nov.)
Author:Motobayashi, Mitsuo; Shigemura, Tomonari; Tanaka, Miyuki; Kurata, Takashi; Kobayashi, Norimoto; Agematsu, Kazunaga; Amano, Yoshiro; Inaba, Yuji; Koike, Kenichi; Nakazawa, Yozo;


若年性皮膚筋炎における間質性肺病変 (特集 小児リウマチ性疾患の最新治療) -- (その他の膠原病)
小児科診療,78(8):1109-1114 2015(Aug.)
Author:小林 法元;
Keywords:急速進行性間質性肺病変; 抗MDA5抗体; びまん性肺胞障害; 非特異性間質性肺炎;


Clinical and laboratory features of fatal rapidly progressive interstitial lung disease associated with juvenile dermatomyositis
RHEUMATOLOGY,54(5):784-791 2015(May)
Author:Kobayashi, Norimoto; Takezaki, Shunichiro; Kobayashi, Ichiro; Iwata, Naomi; Mori, Masaaki; Nagai, Kazushige; Nakano, Naoko; Miyoshi, Mari; Kinjo, Noriko; Murata, Takuji; Masunaga, Kenji; Umebayashi, Hiroaki; Imagawa, Tomoyuki; Agematsu, Kazunaga; Sato, Shinji; Kuwana, Masataka; Yamada, Masafumi; Takei, Shuji; Yokota, Shumpei; Koike, Kenichi; Ariga, Tadashi;


Clinical and laboratory features of fatal rapidly progressive interstitial lung disease associated with juvenile dermatomyositis
RHEUMATOLOGY,54(5):784-791 2015(May)
Author:Kobayashi, Norimoto; Takezaki, Shunichiro; Kobayashi, Ichiro; Iwata, Naomi; Mori, Masaaki; Nagai, Kazushige; Nakano, Naoko; Miyoshi, Mari; Kinjo, Noriko; Murata, Takuji; Masunaga, Kenji; Umebayashi, Hiroaki; Imagawa, Tomoyuki; Agematsu, Kazunaga; Sato, Shinji; Kuwana, Masataka; Yamada, Masafumi; Takei, Shuji; Yokota, Shumpei; Koike, Kenichi; Ariga, Tadashi;


An Increase in Circulating B Cell-Activating Factor in Childhood-Onset Ocular Myasthenia Gravis
PEDIATRIC NEUROLOGY,52(4):404-409 2015(Apr.)
Author:Motobayashi, Mitsuo; Inaba, Yuji; Nishimura, Takafumi; Kobayashi, Norimoto; Nakazawa, Yozo; Koike, Kenichi;


Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes
ANNALS OF THE RHEUMATIC DISEASES,74(3):603-610 2015(Mar.)
Author:Nakagawa, Kenji; Gonzalez-Roca, Eva; Souto, Alejandro; Kawai, Toshinao; Umebayashi, Hiroaki; Maria Campistol, Josep; Canellas, Jeronima; Takei, Syuji; Kobayashi, Norimoto; Luis Callejas-Rubio, Jose; Ortego-Centeno, Norberto; Ruiz-Ortiz, Estibaliz; Rius, Fina; Anton, Jordi; Iglesias, Estibaliz; Jimenez-Trevino, Santiago; Vargas, Carmen; Fernandez-Martin, Julian; Calvo, Inmaculada; Hernandez-Rodriguez, Jose; Mendez, Maria; Teresa Dordal, Maria; Basagana, Maria; Bujan, Segundo; Yashiro, Masato; Kubota, Tetsuo; Koike, Ryuji; Akuta, Naoko; Shimoyama, Kumiko; Iwata, Naomi; Saito, Megumu K.; Ohara, Osamu; Kambe, Naotomo; Yasumi, Takahiro; Izawa, Kazushi; Kawai, Tomoki; Heike, Toshio; Yaguee, Jordi; Nishikomori, Ryuta; Arostegui, Juan I.;


Dramatic Improvement in the Multifocal Positron Emission Tomography Findings of a Young Adult with Chronic Granulomatous Disease Following Allogeneic Hematopoietic Stem Cell Transplantation
JOURNAL OF CLINICAL IMMUNOLOGY,35(1):84-86 2015(Jan.)
Author:Shigemura, Tomonari; Nakazawa, Yozo; Hirabayashi, Koichi; Kobayashi, Norimoto; Sakashita, Kazuo; Agematsu, Kazunaga; Koike, Kenichi;


Dramatic Improvement in the Multifocal Positron Emission Tomography Findings of a Young Adult with Chronic Granulomatous Disease Following Allogeneic Hematopoietic Stem Cell Transplantation
JOURNAL OF CLINICAL IMMUNOLOGY,35(1):84-86 2015(Jan.)
Author:Shigemura, Tomonari; Nakazawa, Yozo; Hirabayashi, Koichi; Kobayashi, Norimoto; Sakashita, Kazuo; Agematsu, Kazunaga; Koike, Kenichi;


Successful treatment for West syndrome with severe combined immunodeficiency
BRAIN & DEVELOPMENT,37(1):140-144 2015(Jan.)
Author:Motobayashi, Mitsuo; Inaba, Yuji; Fukuyama, Tetsuhiro; Kurata, Takashi; Niimi, Taemi; Saito, Shoji; Shiba, Naoko; Nishimura, Takafumi; Shigemura, Tomonari; Nakazawa, Yozo; Kobayashi, Norimoto; Sakashita, Kazuo; Agematsu, Kazunaga; Ichikawa, Motoki; Koike, Kenichi;


Clinical Course in a Patient With Neutrophil-Specific Granule Deficiency and Rapid Detection of Neutrophil Granules as a Screening Test
JOURNAL OF CLINICAL IMMUNOLOGY,34(7):780-783 2014(Oct.)
Author:Shigemura, Tomonari; Yamazaki, Takashi; Shiohara, Masaaki; Kobayashi, Norimoto; Naganuma, Kuniaki; Koike, Kenich; Agematsu, Kazunaga;


Serial monitoring of Mucorales DNA load in serum samples of a patient with disseminated mucormycosis after allogeneic bone marrow transplantation
INTERNATIONAL JOURNAL OF HEMATOLOGY,100(2):206-209 2014(Aug.)
Author:Shigemura, Tomonari; Nakazawa, Yozo; Matsuda, Kazuyuki; Sano, Kenji; Yaguchi, Takashi; Motobayashi, Mitsuo; Saito, Shoji; Noda, Shunsuke; Kobayashi, Norimoto; Agematsu, Kazunaga; Honda, Takayuki; Koike, Kenichi;


Successful cord blood transplantation after repeated transfusions of unmobilized neutrophils in addition to antifungal treatment in an infant with chronic granulomatous disease complicated by invasive pulmonary aspergillosis
TRANSFUSION,54(3):516-521 2014(Mar.)
Author:Shigemura, Tomonari; Nakazawa, Yozo; Yoshikawa, Kentaro; Hirabayashi, Koichi; Saito, Shoji; Kobayashi, Norimoto; Sakashita, Kazuo; Shiohara, Masaaki; Wada, Taizo; Shimodaira, Shigetaka; Agematsu, Kazunaga; Koike, Kenichi;


Successful cord blood transplantation after repeated transfusions of unmobilized neutrophils in addition to antifungal treatment in an infant with chronic granulomatous disease complicated by invasive pulmonary aspergillosis.
Transfusion,54(3):516 2014(Mar.)
Author:Shigemura T, Nakazawa Y, Yoshikawa K, Hirabayashi K, Saito S, Kobayashi N, Sakashita K, Shiohara M, Wada T, Shimodaira S, Agematsu K, Koike K.


Clinical Utility of Anti-CADM-140/Melanoma Differentiation-Associated Gene 5 Autoantibody Titers in Patients with Juvenile Dermatomyositis and Rapidly Progressive Interstitial Lung Disease
ARTHRITIS AND RHEUMATISM,64(10):S128-S128 2012(Oct.)
Author:Sato, Shinji; Kobayashi, Norimoto; Yamazaki, Kazuko; Suzuki, Yasuo;


Food allergy after cord blood transplantation in children.
Br J Haematol,158(5):1365 2012(Sep.)
Author:Sakashita K, Nakazawa Y, Yanagisawa R, Tanaka M, Saito S, Yoshikawa K, Hirabayashi K, Kusakari M, Kato S, Hidaka N, Nakayama Y, Shigemura T, Kobayashi N, Kobayashi M, Shiohara M, Koike K.


TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells.
J Immunol,185(11):6839-49 2010
Author:Albacker LA, Karisola P, Chang YJ, Umetsu SE, Zhou M, Akbari O, Kobayashi N, Baumgarth N, Freeman GJ, Umetsu DT, DeKruyff RH.


Distinct response in maintenance of human naive and memory B cells via IL-21 receptor and TCL1/Akt pathways.
Cell Immunol,256(1-2):56 2009
Author:Nagumo H, Abe J, Kano H, Taki S, Yamazaki K, Yamazaki T, Kobayashi N, Koike K, Sugane K, Saito H, Agematsu K.


TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.
Immunity,27(6):927-40 2007
Author:Kobayashi N, Karisola P, Peña-Cruz V, Dorfman DM, Jinushi M, Umetsu SE, Butte MJ, Nagumo H, Chernova I, Zhu B, Sharpe AH, Ito S, Dranoff G, Kaplan GG, Casasnovas JM, Umetsu DT, Dekruyff RH, Freeman GJ


CD30+anaplastic large cell lymphoma complicated by pyoderma gangrenosum with increased levels of serum cytokines
EUROPEAN JOURNAL OF HAEMATOLOGY,77(3):251-254 2006
Author:Saito, S; Yasui, K; Hosoda, W; Ogawa, M; Kobayashi, N; Sakashita, K; Koike, K


Successful treatment with methotrexate of a child with atlantoaxial subluxation from enthesitis-related arthritis
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY,24(2):211-212 2006
Author:Kobayashi, N; Yasui, K; Nagumo, H; Agematsu, K; Koike, K


Differential effects of short-acting beta(2)-agonists on human granulocyte functions
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY,139(1):1-8 2006
Author:Yasui, K; Kobayashi, N; Yamazaki, T; Agematsu, K; Matsuzaki, S; Nakata, S; Baba, A


Effective combination therapy using interferon-gamma and interleukin-2 for disseminated Mycobacterium avium complexinfection in a pediatric patient with AIDS
Clin Infect Dis,41:e104-e106 2005
Author:Sekiguchi Y, Yasui K, Yamazaki T, Agematsu K, Kobayashi N, Koike K


Thalidomide as an immunotherapeutic agent: The effects on neutrophil-mediated inflammation
CURRENT PHARMACEUTICAL DESIGN,11(3):395-401 2005
Author:Yasui, K; Kobayashi, N; Yamazaki, T; Agematsu, K


Neutrophil-mediated inflammation in respiratory syncytial viral bronchiolitis
Pediatr Int,47:190-195 2005
Author:Yasui K, Baba A, Iwasaki Y, Kubo T, Aoyama K, Mori T, Yamazaki T, Kobayashi N, Ishiguro A


Neutrophilic inflammation in childhood bronchial asthma
Thorax,60:704-705 2005
Author:Yasui K, Kobayashi N, Yamazaki T, Koike K, Fukushima K, Taniuchi S, Kobayashi Y


Superoxide dismutase (SOD) as a potential inhibitory mediator ofinflammation via neutrophil apoptosis
Free Radic Res,39:755-762 2005
Author:Yasui K, Kobayashi N, Yamazaki T, Agematsu K, Matsuzaki S, Ito S, Nakata S, Baba A, Koike K


Polarization of Th1/Th2 in human CD4+ T cells separated by CD62L: analysis by transcription factors
Allergy,60:780-787 2005
Author:Matsuzaki S, Shinozaki K, Kobayashi N, Agematsu K


Bilineage acute leukemia of T-lymphoid and myeloid lineages
Haematologica,89:1139-1141 2004
Author:Kobayashi N, Matsuda K, Sakashita K, Matsuzaki S, Iwasaki R, Koike K


Novel Artemis gene mutations of radiosensitive severe combined immunodeficiency in Japanese families
Hum Genet,112:348-352 2003
Author:Kobayashi N, Agematsu K, Sugita K, Sako M, Nonoyama S, Yachie A, Kumaki S, Tsuchiya S, Ochs HD, Sugita K, Fukushima Y, Komiyama A


Expansion of clonotype-restricted HLA-identical maternal CD4+ T cells in a patient with severe combined immunodeficiency and a homozygous mutation in the Artemis gene
Clin Immunol,108:159-166 2003
Author:Kobayashi N, Agematsu K, Nagumo H, Yasui K, Katsuyama Y, Yoshizawa K, Ota M, Yachie A, Komiyama A


The different process of class switching and somatic hypermutation; a novel analysis by CD27(-) naive B cells
BLOOD,99(2):567-575 2002
Author:Nagumo, H; Agematsu, K; Kobayashi, N; Shinozaki, K; Hokibara, S; Nagase, H; Takamoto, M; Yasui, K; Sugane, K; Komiyama, A


Interferon-gamma and interteukin-2 combination therapy for a AIDS girl with mycobacterium avium-intracellulare complex infection.
CLINICAL IMMUNOLOGY,103(3):S78-S78 2002
Author:Sekiguchi, Y; Kobayashi, N; Nagumo, H; Agematsu, K; Komiyama, A


Absence of memory B cells in patients with common variable immunodeficiency
Clin Immunol,103:34-42 2002
Author:Agematsu K, Futatani T, Hokibara N, Kobayashi H, Takamoto M, Tsukada S, Suzuki H, Koyasu S, Miyawaki T, Sugane K, Komiyama A, Ochs HD


IL-10 enhances B-cell IgE synthesis by promoting differentiation into plasma cells, a process that is inhibited by CD27/CD70 interaction
Clin Exp Immunol,129:446-452 2002
Author:Kobayashi N, Nagumo H, Agematsu K

研究費
科学研究費補助金(研究代表者)
2016 - 2018 , MDA5,抗MDA5抗体の機能解析による重症間質性肺障害発症機構の解明 , 基盤研究(C)
研究諸活動
学術専門雑誌等編集
-2020 , 日本小児リウマチ学会誌